text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the noncompetitive receptor antagonist , 1- [ 1- ( 2-thienyl ) cyclohexyl ] piperidine , administered ( 1 mg/kg i.p . ) before the induction of focal ischemia , similarly and significantly decreased the final volume of infarction . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
150,
158
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
219,
229
]
} |
the voltage dependence of the binding of dihydropyridine ca channel blockers ( + ) - [ 3h ] pn200-110 and [ 3h ] nitrendipine to enzymatically isolated guinea pig ventricular myocytes was examined . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
41,
56
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
113,
125
]
} |
at 1 hr after mca-o , there were no significant differences in regional concentrations of endogenous opioid peptides ( dynorphin , leu-enkephalin and beta-endorphin ) between the injured and uninjured hemispheres . | NA | {
"id": "C0205753",
"name": "endogenous opioid peptides",
"pos": [
90,
116
]
} | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
119,
128
]
} |
inasmuch as the selective lipophilic alpha-2 adrenoceptor antagonist , yohimbine , but not the polar alpha adrenoceptor antagonist , phentolamine , reversed the mydriatic effects of clonidine and cocaine , these data suggest that centrally located alpha-2 adrenoceptors elicit the above mydriatic response . | NA | {
"id": "C0034784",
"name": "alpha adrenoceptor",
"pos": [
101,
119
]
} | {
"id": "C0001639",
"name": "alpha-2 adrenoceptors",
"pos": [
248,
269
]
} |
both delta selective peptides , [ d-ala2 , d-leu5 ] -enkephalin , met-enkephalin and leu-enkephalin , and preferential kappa ligands , dynorphin1-13 and ethylketocyclazocine , significantly reduced the vasoconstriction evoked by 8 pulses at 8 hz . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
53,
63
]
} | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
66,
80
]
} |
both delta selective peptides , [ d-ala2 , d-leu5 ] -enkephalin , met-enkephalin and leu-enkephalin , and preferential kappa ligands , dynorphin1-13 and ethylketocyclazocine , significantly reduced the vasoconstriction evoked by 8 pulses at 8 hz . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
53,
63
]
} | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
85,
99
]
} |
carbachol or oxotremorine , but not nicotine , i.c.v. , enhanced hypnotic sensitivity to ethanol markedly , as measured by blood ethanol concentration at loss or righting response , in short-sleep ( ss ) but not long-sleep ( ls ) mice . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
89,
96
]
} | {
"id": "C0684262",
"name": "blood ethanol concentration",
"pos": [
123,
150
]
} |
the order of potency of these agonists in producing negative chronotropic effects was similar to the rank order for their a1 receptor binding activities [ 6-n-cyclohexyladenosine ( cha ) = 6-n- ( r-phenylisopropyl ) -adenosine greater than 5'-n-ethylcarboxamideadenosine ( neca ) = 2-chloroadenosine greater than 2-pheny... | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
169,
178
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
282,
299
]
} |
several additional amino acid amides of tolmetin were similar to the glycine amide in exhibiting increased potency and reduced gastrointestinal toxicity in comparison to equivalent doses of tolmetin sodium . | NA | {
"id": "C0040377",
"name": "tolmetin",
"pos": [
40,
48
]
} | {
"id": "C0087097",
"name": "tolmetin sodium",
"pos": [
190,
205
]
} |
to examine if a similar interaction occurs in arteries , we studied the effects of ltd4 and epi as well as norepinephrine ( norepi ) on isolated rat aortic rings . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
92,
95
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
107,
121
]
} |
however , pretreatment of aortic rings with ltd4 ( 10 ( -7 ) m ) consistently and significantly enhanced the contractile effects of epi and norepi and lowered the threshold concentration of these agonists required to evoke contraction from 4 x 10 ( -9 ) to 3 x 10 ( -10 ) m ( p less than .05 ) . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
132,
135
]
} | {
"id": "C0028351",
"name": "norepi",
"pos": [
140,
146
]
} |
furthermore , the ltd4-induced potentiation of effects of epi or norepi on aortic contraction was blocked by the lt-receptor antagonist fpl-55712 , but not by indomethacin . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
58,
61
]
} | {
"id": "C0028351",
"name": "norepi",
"pos": [
65,
71
]
} |
the platelet serotonergic agonists 1- ( 2,5-dimethoxy-4-iodophenyl ) -2-aminopropane ( doi ) , 5-ht and 5-methoxytryptamine ( 5-meot ) and the antagonist ketanserin were used for comparison of potency and amplitude of response . | NA | {
"id": "C0036751",
"name": "5-ht",
"pos": [
95,
99
]
} | {
"id": "C0000589",
"name": "5-methoxytryptamine",
"pos": [
104,
123
]
} |
parathyroid ( pth ) ( 10 ( -6 ) m ) stimulated a significant increase in total inositol phosphates , inositol monophosphate and inositol trisphosphate , but not inositol bisphosphate in rptc with the peak effect at 2 min . | NA | {
"id": "C0021554",
"name": "inositol",
"pos": [
79,
87
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
161,
169
]
} |
the pronounced synovial hyperplasia often found in rheumatoid joints can be explained at least partially , by the interaction of monocyte-macrophage polypeptides ( monokines ) and lymphocyte polypeptides ( lymphokines ) with synovial fibroblast-like cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
234,
244
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
250,
255
]
} |
we now report that purified recombinant human cytokines , interleukin-1 alpha , interleukin-1 beta , tumor necrosis factor alpha , tumor necrosis factor beta ( or lymphotoxin ) and , to a variable extent , interferon-gamma , stimulate the dna synthesis of human synovial fibroblast-like cells cultured in low ( i.e. , 1 ... | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
271,
281
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
287,
292
]
} |
a review of 60 patients with primary small bowel tumours seen at the university hospital , jamaica , during the 15 year period 1971-1985 , revealed that adenocarcinoma was the commonest tumour ( 27 % ) , followed by smooth muscle tumour ( 23 % ) , and carcinoids ( 11 % ) . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
153,
167
]
} | {
"id": "C0007095",
"name": "carcinoids",
"pos": [
252,
262
]
} |
the most common clinical presentation was intestinal obstruction , followed by pain , weight loss , abdominal mass and intussusception . | NA | {
"id": "C0021843",
"name": "intestinal obstruction",
"pos": [
42,
64
]
} | {
"id": "C0021933",
"name": "intussusception",
"pos": [
119,
134
]
} |
the 11 beta-lactams included second generation cephems ( cefsulodin , cefotiam and cefmetazole ) , third generation cephems ( ceftazidime , latamoxef , cefmenoxime , cefoperazone , cefotetan and cefpiramide ) and monobactams ( carumonam and aztreonam ) . | NA | {
"id": "C0282215",
"name": "beta-lactams",
"pos": [
7,
19
]
} | {
"id": "C0026458",
"name": "monobactams",
"pos": [
213,
224
]
} |
among these strains of bacteria , 20 strains of s. aureus and 1 strain of s. pyogenes were also used , at the same inoculum size , for the determination of mics of 4 beta-lactam antibiotics including 3 different penicillins such as ampicillin ( abpc ) , methicillin ( dmppc ) and cloxacillin ( mcipc ) and cefaclor ( ccl... | NA | {
"id": "C0030842",
"name": "penicillins",
"pos": [
212,
223
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
254,
265
]
} |
the increase in hepatic cholesterol with dietary cholesterol was observed only in male adult rats . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
24,
35
]
} | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
41,
60
]
} |
the accelerated aging process in cultured chondrocytes is completed within a month and is manifested by typical changes in both cellular and extracellular compartments . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
42,
54
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
146,
154
]
} |
studies on cigarette smokers ' urine , blood and placenta have provided indications of carcinogen exposure , and although the presence of covalently-bound adducts in human dna provides evidence of exposure to carcinogens , there have been no reports of systematic studies on the levels of dna adducts in human lung . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
172,
175
]
} | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
289,
300
]
} |
1 ) the average blood levels of anterior pituitary hormones in these brain death patients were within normal range , and that of growth hormone was more than the twice of the normal level . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
32,
50
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
129,
143
]
} |
the progression of the symptoms showed a spontaneous remission in a short length of time ( 6-22 months ) in most infants . | NA | {
"id": "C0242656",
"name": "progression",
"pos": [
4,
15
]
} | {
"id": "C0035053",
"name": "spontaneous remission",
"pos": [
41,
62
]
} |
this binding can not be displaced by glycine and d-serine , but actually is enhanced by these amino acids in a dose-dependent manner . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
37,
44
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
94,
105
]
} |
screening of a total of 70 fresh human malignant lymphomas by immunohistochemical staining indicates the presence of the c-myb protein primarily in non-hodgkin 's lymphomas with a large growth fraction , i.e . precursor cell-derived lymphoblastic lymphomas of b-cell type and t-cell type ( 9/10 , 3/4 , respectively ) an... | NA | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
39,
58
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
148,
172
]
} |
in nih3t3 cells stably transfected with the human c-fos gene , serum , platelet derived growth factor ( pdgf ) , phorbol ester ( 12-o-tetradecanoyl-phorbol-13-acetate , tpa ) , ultraviolet irradiation ( uv ) and 3'-5'-cyclic adenosine monophosphate ( camp ) cause a transient and rapid activation of both the endogenous ... | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
113,
126
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol-13-acetate",
"pos": [
129,
166
]
} |
in cells treated with the cyclic amp-elevating agents forskolin or prostaglandin e1 or with the permeable cyclic amp analogue , 8-bromo cyclic amp , the levels of c-fos messenger rna were 5 to 10 % of those induced by bombesin , which activates protein kinase c . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
26,
36
]
} | {
"id": "C0000661",
"name": "8-bromo",
"pos": [
128,
135
]
} |
using a sensitive and specific assay , gc/selected ion monitoring after high-performance liquid chromatography separation , we have measured the levels of three hete isomers of biologic significance 12-hete , 15-hete , and 5-hete in plasma , serum and stimulated serum ( formed in the presence of arachidonic acid and ca... | NA | {
"id": "C0044800",
"name": "hete",
"pos": [
161,
165
]
} | {
"id": "C0020349",
"name": "hete",
"pos": [
225,
229
]
} |
whereas there were no significant differences between the two groups for 5- or 15-hete in any of the samples , stimulated serum from adults produced 12 times as much 12-hete when compared to cord blood . | NA | {
"id": "C0020349",
"name": "hete",
"pos": [
82,
86
]
} | {
"id": "C0044800",
"name": "12",
"pos": [
166,
168
]
} |
although no role for 12-hete in normal platelet responses has yet been established , it has been reported that those individuals with myeloproliferative syndromes who demonstrate a concomitant decrease in platelet 12-hete synthetic ability have an increased bleeding tendency . | NA | {
"id": "C0044800",
"name": "12-hete",
"pos": [
21,
28
]
} | {
"id": "C0020349",
"name": "hete",
"pos": [
217,
221
]
} |
peak pp levels were also significantly correlated with the peak epinephrine levels ( r = 0.6 , p less than 0.001 ) but not with norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
64,
75
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
128,
142
]
} |
this study examines the effect of premature delivery on the switch from fetal ( alpha 2 tau 2 ) to adult ( alpha 2 beta 2 ) hb , in lambs in which premature parturition was induced by the intrafetal infusion of acth or corticotropin releasing hormone . | NA | {
"id": "C0151526",
"name": "premature delivery",
"pos": [
34,
52
]
} | {
"id": "C0022876",
"name": "premature",
"pos": [
147,
156
]
} |
furthermore , the probe contains the sp1 consensus binding sequence 5'ccgccc3 ' , in addition to the mre consensus sequence , 5'tgcac3 ' , and we show that a simian virus 40 dna fragment which contains six sp1 binding sites did not bind p108 nor did it compete for the protein ( s ) interacting with mred in a dna footpr... | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
174,
177
]
} | {
"id": "C0000702",
"name": "a dna",
"pos": [
308,
313
]
} |
these results show that a metal regulatory element of the mouse mt-1 gene interacts specifically with a nuclear protein of mr 108,000 and that this protein is distinct from the transcription factor sp1 . | NA | {
"id": "C0028589",
"name": "nuclear protein",
"pos": [
104,
119
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
148,
155
]
} |
the predicted sequence of this protein reveals no extensive similarity to other snrnp proteins , but contains regions of similarity to a eukaryotic ribosomal protein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
86,
94
]
} | {
"id": "C0035552",
"name": "ribosomal protein",
"pos": [
148,
165
]
} |
pulse labelling of ultraviolet ( 254 nm ) irradiated confluent human fibroblasts revealed that repair was preferentially located in nuclear matrix associated dna in cells exposed to 5 j/m2 . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
69,
80
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
165,
170
]
} |
a 36 base pair chimeric oligonucleotide containing a central core of dna duplex flanked by rna/dna hybrid at each end was synthesized . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
95,
98
]
} |
enzyme linked immunosorbent assays ( elisa ) and a gel electrophoresis retardation assay were used to demonstrate the binding of antibodies which recognize b-dna , z-dna and rna/dna hybrid . | NA | {
"id": "C0919262",
"name": "b-dna",
"pos": [
156,
161
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
178,
181
]
} |
enzyme linked immunosorbent assays ( elisa ) and a gel electrophoresis retardation assay were used to demonstrate the binding of antibodies which recognize b-dna , z-dna and rna/dna hybrid . | NA | {
"id": "C0043442",
"name": "z-dna",
"pos": [
164,
169
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
178,
181
]
} |
nuclear factor i ( nf1 ) is a dna binding protein that is known to function in the replication of adeno virus and also binds to many promoters recognized by rna polymerase ii . | NA | {
"id": "C0069116",
"name": "nuclear factor i",
"pos": [
0,
16
]
} | {
"id": "C0012940",
"name": "dna binding protein",
"pos": [
30,
49
]
} |
protein-rna interactions in small nuclear ribonucleoproteins ( usnrnps ) from hela cells were investigated by irradiation of purified nucleoplasmic snrnps u1 to u6 with uv light at 254 nm . | NA | {
"id": "C0142661",
"name": "small nuclear ribonucleoproteins",
"pos": [
28,
60
]
} | {
"id": "C0162795",
"name": "snrnps u1",
"pos": [
148,
157
]
} |
the efficacy and risks of transabdominal free-hand ultrasound-guided fine needle aspiration technique were evaluated in 1159 pregnancies submitted to chorionic villus sampling ( cvs ) in the first trimester and early in the second trimester . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
125,
136
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
191,
206
]
} |
the efficacy and risks of transabdominal free-hand ultrasound-guided fine needle aspiration technique were evaluated in 1159 pregnancies submitted to chorionic villus sampling ( cvs ) in the first trimester and early in the second trimester . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
125,
136
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
224,
240
]
} |
with this method , the catalytic activity of cpt can be measured , and enzyme inhibition by its substrate and the product of the reaction ( palmityl coa and palmitylcarnitine respectively ) can be studied . | NA | {
"id": "C0007258",
"name": "cpt",
"pos": [
45,
48
]
} | {
"id": "C0030242",
"name": "palmitylcarnitine",
"pos": [
157,
174
]
} |
the syndrome always followed a favourable course and disappeared when the causative disease was cured ; | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
4,
12
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
84,
91
]
} |
to determine the therapeutic usefulness of benzimidazoles in trichinellosis , 117 patients from a single outbreak were treated either with albendazole alone ( n = 59 ) or with a regimen including tiabendazole followed by flubendazole ( n = 58 ) . | NA | {
"id": "C0005050",
"name": "benzimidazoles",
"pos": [
43,
57
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
139,
150
]
} |
to determine the therapeutic usefulness of benzimidazoles in trichinellosis , 117 patients from a single outbreak were treated either with albendazole alone ( n = 59 ) or with a regimen including tiabendazole followed by flubendazole ( n = 58 ) . | NA | {
"id": "C0005050",
"name": "benzimidazoles",
"pos": [
43,
57
]
} | {
"id": "C0039832",
"name": "tiabendazole",
"pos": [
196,
208
]
} |
stage-specific proteins of plasmodium berghei-infected red blood cells detected by antibodies of immune mouse serum . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
83,
93
]
} | {
"id": "C0020960",
"name": "immune",
"pos": [
97,
103
]
} |
radical i , the o6-protonated anion , decays at 250 k yielding a stable room temperature radical ( radical v ) . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
3,
4
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
30,
35
]
} |
radiation-induced tumor growth delay ( 7.11 +/- 1.76 days ) was enhanced only when tumors were irradiated 2-4 h after 50 mg/kg ddc . | NA | {
"id": "C0027666",
"name": "radiation-induced tumor",
"pos": [
0,
23
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
83,
89
]
} |
on the contrary , in the late stages of renal amyloidosis , when pathologic changes lead to progressive nephrosclerosis , us findings appear aspecific , since they are undistinguishable from the patterns observed in other renal medical disorders . | NA | {
"id": "C0027719",
"name": "nephrosclerosis",
"pos": [
104,
119
]
} | {
"id": "C0022658",
"name": "renal",
"pos": [
222,
227
]
} |
preliminary evidence suggests that liposome-encapsulated amphotericin b has a wider therapeutic index than free amphotericin b and allows for the use of larger total doses . | NA | {
"id": "C1145701",
"name": "liposome",
"pos": [
35,
43
]
} | {
"id": "C0002679",
"name": "amphotericin",
"pos": [
112,
124
]
} |
role of the mononuclear phagocyte system in the immunopathogenesis of human immunodeficiency virus infection and the acquired immunodeficiency syndrome . | NA | {
"id": "C0019693",
"name": "human",
"pos": [
70,
75
]
} | {
"id": "C0001175",
"name": "acquired immunodeficiency syndrome",
"pos": [
117,
151
]
} |
in studies aimed at defining monocyte and macrophage function in patients with human immunodeficiency virus ( hiv ) infection , we found impaired in vivo fc receptor-specific clearance in 20 of 25 patients with acquired immunodeficiency syndrome ( aids ) and in five of 13 patients with aids-related illnesses . | NA | {
"id": "C0019693",
"name": "human immunodeficiency virus",
"pos": [
79,
107
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
287,
291
]
} |
the binding and concentrations of noradrenaline ( na ) and adrenalin ( adr ) were determined in acute phase plasma after major hip surgery in five subjects . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
34,
47
]
} | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
59,
68
]
} |
all participants were given a supplement to their normal diets of vegetable oil ( 4.8 g n-6 pufa 's ) for 4 weeks and were then randomized to the same oil or to fish oil ( 4.8 g n-3 pufa 's ) for 12 weeks . | NA | {
"id": "C0028908",
"name": "oil",
"pos": [
76,
79
]
} | {
"id": "C0016157",
"name": "fish oil",
"pos": [
161,
169
]
} |
this study showed that pyrophosphate ( pp ) desorbed an acidic protein ( albumin ) from hydroxyapatite ( ha ) more effectively than phosphate and that ha pretreated with pp took up markedly less protein than untreated ha . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
73,
80
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
195,
202
]
} |
the indications for ptca or bypass surgery were postinfarct angina in 41 % , silent ischemia in 5 % , left main coronary artery stenosis or multivessel disease with reduced left ventricular ejection fraction in 16 % , and residual high grade stenosis with preserved contractility of the infarct-related myocardium in 38 ... | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
84,
92
]
} | {
"id": "C0021308",
"name": "infarct",
"pos": [
287,
294
]
} |
interferon has been found to have important clinical activity in hairy-cell leukemia , low-grade non-hodgkin 's lymphoma , cutaneous t cell lymphoma , chronic myelogenous leukemia , previously untreated multiple myeloma , acquired immunodeficiency syndrome-related kaposi 's sarcoma , malignant carcinoid tumors , intrav... | NA | {
"id": "C0079747",
"name": "low-grade",
"pos": [
87,
96
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
97,
111
]
} |
adverse outcomes among the pregnancies and livebirths of the 608 women were reported , including spontaneous abortion , stillbirth , low birth weight , prematurity , congenital anomalies , and complications of pregnancy or delivery . | NA | {
"id": "C0000786",
"name": "spontaneous abortion",
"pos": [
97,
117
]
} | {
"id": "C0032962",
"name": "complications of pregnancy",
"pos": [
193,
219
]
} |
comparison of soluble dexamethasone sodium phosphate with free dexamethasone and indomethacin in treatment of experimental neoplastic spinal cord compression . | NA | {
"id": "C0113286",
"name": "dexamethasone sodium phosphate",
"pos": [
22,
52
]
} | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
63,
76
]
} |
the effect of treatment given on onset of paraplegia with either dexamethasone sodium phosphate ( dex-p ; 10 mg/kg twice daily ) , or free dexamethasone ( f-dex ; 8.25 mg/kg twice daily ) or indomethacin ( 10 mg/kg twice daily ) , was evaluated after 30 hours of therapy . | NA | {
"id": "C0113286",
"name": "dexamethasone",
"pos": [
65,
78
]
} | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
139,
152
]
} |
an indirect enzyme-linked immunosorbent assay ( elisa ) was evaluated for the detection of anti-amoebic igg and igm antibodies to assess its value in distinguishing past from current infection in invasive amoebiasis , particularly in amoebic liver abscess ( ala ) patients . | NA | {
"id": "C0002438",
"name": "amoebiasis",
"pos": [
205,
215
]
} | {
"id": "C0023886",
"name": "amoebic liver abscess",
"pos": [
234,
255
]
} |
the most common finding in patients with mandibular dysfunction ( md ) is pain or tenderness of the masticatory muscles , but tender and painful neck and shoulder muscles are also often found in relation to jaw muscle affection . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
74,
78
]
} | {
"id": "C0007859",
"name": "painful neck",
"pos": [
137,
149
]
} |
a conclusion has been made that in renal pathology a zinc sl does not always reflect the content of zinc in the body however zinc acetate therapy is effective in the treatment of hg patients as well as in the treatment of retarded physical and sexual development in adolescents with nephropathies . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
53,
57
]
} | {
"id": "C0149368",
"name": "zinc acetate",
"pos": [
125,
137
]
} |
ergotamine , ergonovine , and methylergonovine induced a significantly high number of sces at all the concentrations used , while with ergocristine this occurred only at the highest concentration . alpha-ergocryptine failed to induce sces at any concentration . | NA | {
"id": "C0014704",
"name": "ergonovine",
"pos": [
13,
23
]
} | {
"id": "C0025760",
"name": "methylergonovine",
"pos": [
30,
46
]
} |
it is therefore surmised that ergotamine , ergonovine , and methylergonovine are effective inducers , ergocristine is a weak inducer , and alpha-ergocryptine is a noninducer in chinese hamster ovary cells in vitro . | NA | {
"id": "C0014704",
"name": "ergonovine",
"pos": [
43,
53
]
} | {
"id": "C0025760",
"name": "methylergonovine",
"pos": [
60,
76
]
} |
the pa ( oc-1-pa ) produced by the cell line was purified and compared with urokinase ( u-pa ) , proform of uk ( scu-pa ) , and tissue-type pa ( t-pa ) purified from human melanoma cells ( bowes ) . | NA | {
"id": "C0032144",
"name": "pa",
"pos": [
4,
6
]
} | {
"id": "C0032143",
"name": "tissue-type pa",
"pos": [
128,
142
]
} |
the highest binding affinity was found with recombinant tissue-type plasminogen activator ( t-pa ) , followed by lysyl-plasminogen and glutamyl-plasminogen ( glu-plg ) with intermediate affinity , but very low affinity by single chain uk-type plasminogen activator , high molecular weight uk and low molecular weight uk ... | NA | {
"id": "C0032143",
"name": "recombinant tissue",
"pos": [
44,
62
]
} | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
243,
264
]
} |
[ parental education in relation to fetal death and death during the first year of life ] . | NA | {
"id": "C0524342",
"name": "parental",
"pos": [
2,
10
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
52,
57
]
} |
derivation of retinoic acid and metabolites from a teratogenic dose of retinol ( vitamin a ) in mice . | NA | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
14,
27
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
81,
90
]
} |
retinoic acid ( all-trans-ra ) is a natural metabolite of vitamin a which participates in many of the known functions of vitamin a and may be the active agent in teratogenesis . | NA | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
0,
13
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
121,
130
]
} |
positivity was not observed in patients who received marrow depleted of t lymphocytes , indicating a crucial role for these cells in stimulating keratinocyte hla-dr expression . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
124,
129
]
} | {
"id": "C0022567",
"name": "hla-dr",
"pos": [
158,
164
]
} |
antibody and complement depletion experiments showed that both anti-yac-1 and anti-p815 activity could be depleted with antiserum to the asialo-gm1 cell surface marker , but was unaffected by anti-lyt-1.2 and anti-lyt-2.2 treatment . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
120,
129
]
} |
being stored in the mitochondria , cd2+ inhibits respiration and an energy dependent transport of penetrating cations ( cs+-valinomycin ) , and disturbs passive permeability of the inner mitochondrial membrane for monovalent cations and h+ . | NA | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
214,
232
]
} | {
"id": "C0033727",
"name": "h",
"pos": [
237,
238
]
} |
[ gastric mucosa barrier and the effect of non-steroidal anti-inflammatory agents and corticosteroid hormones on the gastric and duodenal mucosa ] . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
86,
100
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
101,
109
]
} |
grem 's salt , tripolyphosphate and pyrophosphate were shown to cause the stimulatory effect on the peptide formation , but there was no correlation between the yield of the peptides and the hydrolysis of the polyphosphates . | NA | {
"id": "C0034320",
"name": "pyrophosphate",
"pos": [
36,
49
]
} | {
"id": "C0032575",
"name": "polyphosphates",
"pos": [
209,
223
]
} |
outdoor temperature below the annual mean of 5.9 degrees c in combination with a sudden decrease in temperature was associated with sudden deaths , particularly sids . | NA | {
"id": "C0011071",
"name": "sudden deaths",
"pos": [
132,
145
]
} | {
"id": "C0038644",
"name": "sids",
"pos": [
161,
165
]
} |
the urinary excretion of collagen metabolites ( hydroxylysine , hydroxyproline and proline ) was significantly increased in 10 patients with cystic fibrosis and chronic broncho-pulmonary pseudomonas aeruginosa infection as compared with 14 age matched controls . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
64,
78
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
83,
90
]
} |
patients with seizures starting before the age of 10 years tended to have intractable epilepsy , to receive multiple antiepileptic drug therapies , and to have poor courses including problems not related to epilepsy . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
14,
22
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
207,
215
]
} |
intravenous thrombolytic treatment ( streptokinase or anisoylated plasminogen streptokinase activator complex ( apsac ) was given to 50 consecutive patients within 3 hours after onset of symptoms of acute myocardial infarction . | NA | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
37,
50
]
} | {
"id": "C0078956",
"name": "anisoylated plasminogen",
"pos": [
54,
77
]
} |
the lung dust composition in this case was approximately 43 % silicon carbide , 24 % aluminium oxide , 2.3 % cristobalite , 2.0 % quartz , and trace of talc and feldspar . | NA | {
"id": "C0037098",
"name": "cristobalite",
"pos": [
109,
121
]
} | {
"id": "C0034387",
"name": "quartz",
"pos": [
130,
136
]
} |
maternal 17 beta-estradiol and estriol levels were reduced during the third trimester in women with syphilis when compared with those in women with uncomplicated pregnancies . | NA | {
"id": "C0032981",
"name": "third trimester",
"pos": [
70,
85
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
162,
173
]
} |
atrial natriuretic factor , digoxin-like immunoreactive substance , norepinephrine , epinephrine , and plasma renin activity in human fetuses and their alteration by fetal disease . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
68,
82
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
85,
96
]
} |
norms for atrial natriuretic factor , digoxin-like immunoreactive substance , plasma renin activity , norepinephrine , and epinephrine were derived from fetuses ultimately shown to be free of detectable abnormality . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
102,
116
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
123,
134
]
} |
with these novel approaches to the collection and representation of glucose data , the severity of glucose intolerance ( hyperglycemia ) was found to be associated with both maternal and neonatal morbidity in terms of infant size and cesarean section rate . | NA | {
"id": "C0271650",
"name": "glucose intolerance",
"pos": [
99,
118
]
} | {
"id": "C0020456",
"name": "hyperglycemia",
"pos": [
121,
134
]
} |
using the postimplantation rat conceptus model , we analyzed with gas-liquid chromatography , the fatty acid composition in major lipid groups ( phospholipids , triglycerides , nonesterified fatty acids , and cholesterol esters ) of yolk sacs and embryos cultured for 48 hours under control , hyperglycemic , and arachid... | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
98,
108
]
} | {
"id": "C0015688",
"name": "nonesterified fatty acids",
"pos": [
177,
202
]
} |
in all experimental conditions the yolk sacs had greater fatty acid content than the embryos in all lipid groups except in nonesterified fatty acids . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
57,
67
]
} | {
"id": "C0015688",
"name": "nonesterified fatty acids",
"pos": [
123,
148
]
} |
oleic acid , a fatty acid associated with essential fatty acid deficiency , was increased in the embryonic phospholipids and nonesterified fatty acids of conceptuses exposed to excess glucose , as well as in the culture media of this group , compared with the control or arachidonic acid-supplemented , hyperglycemic gro... | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
15,
25
]
} | {
"id": "C0015688",
"name": "nonesterified fatty acids",
"pos": [
125,
150
]
} |
in this study , extracts of tachyzoites of 7 toxoplasma strains were compared on the basis of their isoenzyme patterns for 39 enzymes by means of isoelectrofocusing in polyacrylamide gels . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
100,
109
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
126,
133
]
} |
the present study further supports our previous hypothesis that there is an ige-mediated immunological mechanism behind l. des.-induced asthma in farmers and that atopic farmers are liable to develop occupational asthma caused by allergy to l. des.. | NA | {
"id": "C0004096",
"name": "asthma",
"pos": [
136,
142
]
} | {
"id": "C0264423",
"name": "occupational asthma",
"pos": [
200,
219
]
} |
the possibility of employing a similar method with ige instead of igg for preparation of patient-related allergens instead of antigens , is discussed . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
105,
114
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
126,
134
]
} |
the inhibitory effect of orally administered dexchlorfeniramine ( 4 mg/day ) , cyproheptadine ( 8 mg/day ) , astemizole ( 20 mg/day ) , loratadine ( 40 mg/day ) and terfenadine ( 120 mg/day ) on the size of histamine-induced weals was tested by skin prick test with histamine in an open study including 23 healthy indivi... | NA | {
"id": "C0010620",
"name": "cyproheptadine",
"pos": [
79,
93
]
} | {
"id": "C0065180",
"name": "loratadine",
"pos": [
136,
146
]
} |
for all drugs the maximal weal suppression with the dosage chosen was recorded the day after the last dosage , being 29 % ( for dexchlorfeniramine ) , 72 % ( for cyproheptadine ) , 50 % ( for astemizole ) , 62 % ( for loratadine ) , and 56 % ( for terfenadine ) of the baseline value . | NA | {
"id": "C0010620",
"name": "cyproheptadine",
"pos": [
162,
176
]
} | {
"id": "C0065180",
"name": "loratadine",
"pos": [
218,
228
]
} |
the circulating norepinephrine levels were significantly higher in the atopic group ( p less than 0.005 ) , by contrast only slight differences were found in the epinephrine and dopamine concentrations . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
16,
30
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
162,
173
]
} |
our preliminary data with precursor cell lines suggest that these cells give neurons with highly differentiated characteristics . | NA | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
26,
40
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
66,
71
]
} |
a practical classification of colles ' fractures according to intra-articular fracture lines was shown to be useful in assessing the severity of these fractures . | NA | {
"id": "C0332715",
"name": "intra-articular fracture",
"pos": [
62,
86
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
151,
160
]
} |
comminuted intra-articular fractures of the radiocarpal joint , fracture line into the distal radio-ulnar joint , fracture of the ulnar styloid and a poor anatomical result in addition to high age contributed to a poor result . | NA | {
"id": "C0476171",
"name": "comminuted",
"pos": [
0,
10
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
114,
122
]
} |
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