text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
comminuted intra-articular fractures of the radiocarpal joint , fracture line into the distal radio-ulnar joint , fracture of the ulnar styloid and a poor anatomical result in addition to high age contributed to a poor result . | NA | {
"id": "C0332715",
"name": "intra-articular fractures",
"pos": [
11,
36
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
114,
122
]
} |
the purpose of this study was to assess systematically morphology of peripheral nerves from patients with human immunodeficiency virus infection ( acquired immunodeficiency syndrome [ aids ] and aids-related complex ) examined at autopsy . | NA | {
"id": "C0019693",
"name": "human immunodeficiency virus infection",
"pos": [
106,
144
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
195,
199
]
} |
northern analysis was performed on muscle rna in 4 patients : messenger rna was normal in 2 , abnormally short in 1 , and absent in the fourth , indicating heterogeneity of the molecular lesion in mcardle 's disease . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
42,
45
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
62,
75
]
} |
reaction of rheumatoid factors with igg3 monoclonal anti-rh ( d ) antibodies : more frequent reactivity to a monoclonal antibody of the gm allotype g3m ( 5 ) in rheumatoid patients negative for g3m ( 5 ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
66,
76
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
109,
128
]
} |
human monoclonal anti-rh ( d ) antibodies of known igg isotype and gm allotype were bound to erythrocytes and then used as the target igg antigens for rheumatoid factors ( rfs ) in a direct haemagglutination test . | NA | {
"id": "C0020852",
"name": "antibodies",
"pos": [
31,
41
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
55,
62
]
} |
the prevalence of antibodies to the following antigens was as follows : double stranded ( ds ) dna ( 43 % ) , histone ( 81 % ) , sm ( 26 % ) , nuclear ribonuclear protein ( nrnp ) ( 32 % ) , ss-a ( ro ) ( 63 % ) , ss-b ( la ) ( 12 % ) , sl/ki ( 9 % ) , ribosomal rnp ( rrnp ) ( 16 % ) , p70/p80 ( 5 % ) , proliferating c... | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
110,
117
]
} | {
"id": "C0028589",
"name": "nuclear",
"pos": [
324,
331
]
} |
natural human interleukin 1 and recombinant interleukin 1 beta , but not interleukin 1 alpha , suppressed in a dose dependent manner the proliferation of the human erythroleukaemia cell line ( hel ) in cultures , suggesting that the interleukin 1 effect is a direct one . | NA | {
"id": "C0600251",
"name": "interleukin 1 alpha",
"pos": [
73,
92
]
} | {
"id": "C0021755",
"name": "interleukin 1",
"pos": [
233,
246
]
} |
higher concentrations showed a decrease for regular heparins , most marked for beef lung heparin -45 % , compared to -21 % for porcine intestinal heparin , but still an increase , +22 % , was noted for low molecular weight heparin . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
52,
59
]
} | {
"id": "C0019139",
"name": "low molecular weight",
"pos": [
202,
222
]
} |
inhibition of na , k-atpase and sodium pump by anticancer ether lipids and protein kinase c inhibitors et-18-och3 and bm 41.440 . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
21,
27
]
} | {
"id": "C0001479",
"name": "sodium pump",
"pos": [
32,
43
]
} |
these findings demonstrate that ins-1,3,4,6-p4 is an intermediate link between insp3 metabolism and the higher inositol phosphates detected in several tissues . | NA | {
"id": "C0021549",
"name": "insp3",
"pos": [
79,
84
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
111,
130
]
} |
bradykinin stimulated a rapid and parallel increase in approximately equivalent amounts of water soluble ( [ 3h ] choline plus [ 3h ] phosphocholine ) and lipid ( [ 3h ] phosphatidic acid plus [ 3h ] diacylglycerol ) phosphodiesteratic cleavage products of pc . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
114,
121
]
} | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
134,
148
]
} |
in electropermeabilized platelets incubated with [ alpha-32p ] nad , the 37 kda protein is also adp-ribosylated as are other proteins and albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
125,
133
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
138,
145
]
} |
however , the purified tulip lipoxygenase showed a strong immunological crossreactivity with antiserum raised against the purified potato lipoxygenase , indicating close immunological relationship with the other plant lipoxygenases . | NA | {
"id": "C0023837",
"name": "lipoxygenase",
"pos": [
29,
41
]
} | {
"id": "C2936592",
"name": "lipoxygenases",
"pos": [
218,
231
]
} |
the subunit composition of the enzyme from liver , kidney and lung differed from that present in heart , brain and skeletal muscle by the absence of an mr 18,500 protein and the absence of an mr 17,000 protein , suggesting the existence of tissue-specific isoenzymes . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
31,
37
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
256,
266
]
} |
although pertussis toxin ( pt ) treatment caused adp-ribosylation in both nih3t3 cells and ng108-15 cells , the bk-induced ins ( 1,4,5 ) p3 formation was considerably reduced in the former cells but not in the latter cells , suggesting that pt-sensitive and pt-insensitive gtp-binding proteins are involved in phosphoino... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
81,
86
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
368,
379
]
} |
human genomic clones encompassing the tissue specific expressed gene ibp-1 , an insulin-like growth factor binding protein were isolated and characterized . | NA | {
"id": "C0123256",
"name": "ibp-1",
"pos": [
69,
74
]
} | {
"id": "C0074825",
"name": "insulin-like growth factor binding protein",
"pos": [
80,
122
]
} |
it was 100 times more inhibitory to insulin receptor tpk ( ed50 = 61nm ) than igf-i receptor tpk ( ed50 = 6.2 microm ) . | NA | {
"id": "C0206364",
"name": "receptor",
"pos": [
44,
52
]
} | {
"id": "C0140080",
"name": "igf-i receptor",
"pos": [
78,
92
]
} |
the influence of replacing the phenolic hydroxyl by the methoxy group on opioid receptor binding , analgesic and antitussive action was investigated in the corresponding couples morphine-codeine , hydromorphone-hydrocodone and o-desmethyltramadol ( l 235 ) -tramadol . | NA | {
"id": "C0009214",
"name": "codeine",
"pos": [
187,
194
]
} | {
"id": "C0020264",
"name": "hydrocodone",
"pos": [
211,
222
]
} |
codeine and hydrocodone were weaker antitussives than the corresponding hydroxy compounds , whereas no significant difference was found between o-desmethyltramadol and tramadol . | NA | {
"id": "C0009214",
"name": "codeine",
"pos": [
0,
7
]
} | {
"id": "C0020264",
"name": "hydrocodone",
"pos": [
12,
23
]
} |
the anti-prv antibodies induced by one of the antiidiotypic antibody preparations had an affinity for prv comparable to that of the original monoclonal antibody . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
60,
68
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
141,
160
]
} |
7 system expresses a major , cross-reactive idiotype on antibodies to an epitope of the mouse i-e antigen . | NA | {
"id": "C0021013",
"name": "idiotype",
"pos": [
44,
52
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
73,
80
]
} |
the generation of anaphylatoxins ( c3a and c5a ) during hemofiltration with polysulfone ( f60 ) , acrylonitrile ( an69 hf ) , polyamid ( fh77 ) , polyacrylonitrile ( pan200 ) and cellulose-acetate ( duo-flux ) membranes were investigated . | NA | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
18,
32
]
} | {
"id": "C0009510",
"name": "c3a",
"pos": [
35,
38
]
} |
the relative bioavailability of morphine with mst was significantly less than that with mss ( mean 80 % , range 50-110 % ) although there was no difference between the formulations in the relative availability of m3g and m6g . | NA | {
"id": "C0026549",
"name": "morphine",
"pos": [
32,
40
]
} | {
"id": "C0066814",
"name": "mss",
"pos": [
88,
91
]
} |
studies of prochlorperazine as a buccal tablet ( buccastem ) and an oral tablet ( stemetil ) for the treatment of dizziness , nausea or vomiting in a general practice setting . | NA | {
"id": "C1707058",
"name": "buccal tablet",
"pos": [
33,
46
]
} | {
"id": "C0993159",
"name": "oral tablet",
"pos": [
68,
79
]
} |
in contrast to the above compounds , the purr mutants showed no significant cross-resistance to a large number of other drugs which included asaley , at-125 , 5-azacytidine , azaserine , cyclocytidine , cis-platin , cytosine arabinoside , chlorambucil , chlorpromazine , alpha-difluoromethyl ornithine , 5-fluorouracil ,... | NA | {
"id": "C0010557",
"name": "cyclocytidine",
"pos": [
187,
200
]
} | {
"id": "C0010711",
"name": "cytosine arabinoside",
"pos": [
216,
236
]
} |
bone marrow lymphoid nodules in myeloproliferative disorders : association with the nonmyelosclerotic phases of idiopathic myelofibrosis and immunological significance . | NA | {
"id": "C0027022",
"name": "myeloproliferative disorders",
"pos": [
32,
60
]
} | {
"id": "C0001815",
"name": "idiopathic myelofibrosis",
"pos": [
112,
136
]
} |
twelve out of 51 patients with idiopathic myelofibrosis ( im ) showed such a feature ( 23.5 % ) , versus two out of 100 with ph1-positive chronic myeloid leukaemia , two of 32 with polycythaemia vera , and one of 17 with essential thrombocythaemia , the difference between im and the remaining mpd being statistically si... | NA | {
"id": "C0001815",
"name": "im",
"pos": [
58,
60
]
} | {
"id": "C0027022",
"name": "mpd",
"pos": [
294,
297
]
} |
a patient having a b cell chronic lymphocytic leukaemia was treated with a monoclonal anti-idiotypic antibody ( moab anti-id ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
101,
109
]
} | {
"id": "C0003250",
"name": "moab",
"pos": [
112,
116
]
} |
sequence comparisons of rskg-7 , rskg-3 , and other kallikrein-related enzymes reveal the key amino acid residues needed for both serine protease activity ( his/asp/ser ) and kallikrein-like cleavage specificity at basic amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
94,
104
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
215,
232
]
} |
the finding that n-alkylphosphoramidate substituents can enhance the binding of certain oligonucleotides to their complementary polynucleotides suggests the existence of a novel source of polynucleotide affinity . | NA | {
"id": "C0028953",
"name": "oligonucleotides",
"pos": [
88,
104
]
} | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
188,
202
]
} |
using circular dichroism ( cd ) , it was found that when codissolved in trifluoroethanol ( tfe ) , after drying and subsequent hydration , gramicidin is mainly present in the single-stranded beta 6.3-helical configuration , whereas when using chloroform/methanol or ethanol as the solvent , it is proposed that the domin... | NA | {
"id": "C0040983",
"name": "trifluoroethanol",
"pos": [
72,
88
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
266,
273
]
} |
using circular dichroism ( cd ) , it was found that when codissolved in trifluoroethanol ( tfe ) , after drying and subsequent hydration , gramicidin is mainly present in the single-stranded beta 6.3-helical configuration , whereas when using chloroform/methanol or ethanol as the solvent , it is proposed that the domin... | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
254,
262
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
266,
273
]
} |
employing 31p nmr , the stoichiometry for bilayer formation was found to be 6 to 7 lipid molecules per gramicidin monomer , when samples were prepared from tfe , whereas a stoichiometry of 4 was found when chloroform/methanol or ethanol was the solvent . | NA | {
"id": "C0040983",
"name": "tfe",
"pos": [
156,
159
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
229,
236
]
} |
employing 31p nmr , the stoichiometry for bilayer formation was found to be 6 to 7 lipid molecules per gramicidin monomer , when samples were prepared from tfe , whereas a stoichiometry of 4 was found when chloroform/methanol or ethanol was the solvent . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
217,
225
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
229,
236
]
} |
mechanistic deductions from kinetic isotope effects and ph studies of pyridoxal phosphate dependent carbon-carbon lyases : erwinia herbicola and citrobacter freundii tyrosine phenol-lyase . | NA | {
"id": "C0524940",
"name": "carbon-carbon lyases",
"pos": [
100,
120
]
} | {
"id": "C0041493",
"name": "tyrosine phenol-lyase",
"pos": [
166,
187
]
} |
mechanistic deductions from multiple kinetic and solvent deuterium isotope effects and ph studies of pyridoxal phosphate dependent carbon-carbon lyases : escherichia coli tryptophan indole-lyase . | NA | {
"id": "C0524940",
"name": "carbon-carbon lyases",
"pos": [
131,
151
]
} | {
"id": "C0041260",
"name": "tryptophan indole-lyase",
"pos": [
171,
194
]
} |
acyl-coa : cholesterol o-acyltransferase ( ec 2.3.1.26 ) ( acat ) catalyzes the intracellular synthesis of cholesteryl esters from cholesterol and fatty acyl-coa at neutral ph . | NA | {
"id": "C0008380",
"name": "cholesterol",
"pos": [
11,
22
]
} | {
"id": "C0001390",
"name": "acat",
"pos": [
59,
63
]
} |
acyl-coa : cholesterol o-acyltransferase ( ec 2.3.1.26 ) ( acat ) catalyzes the intracellular synthesis of cholesteryl esters from cholesterol and fatty acyl-coa at neutral ph . | NA | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
107,
125
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
131,
142
]
} |
we studied the binding of potassium , calcium , magnesium , spermine , and gentamicin ions to the phosphoinositides by measuring the effect of these cations on the electrophoretic mobility of multilamellar vesicles formed from mixtures of phosphatidylcholine ( pc ) and either phosphatidylinositol , phosphatidylinositol... | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
86,
90
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
149,
156
]
} |
in the presence of nadp+ , one sulfhydryl group was quantitated in the nondenatured soluble enzyme , while none was found in the reconstituted enzyme , suggesting that the reactive sulfhydryl groups were less accessible in the nadp+-enzyme complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
92,
98
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
233,
247
]
} |
rat liver microsomal cytochrome p-450 oxidizes the 4-methyl , 4-ethyl ( ddep ) , and 4-isopropyl derivatives of 3,5-bis ( carbethoxy ) -2,6-dimethyl-1,4-dihydropyridine to mixtures of the corresponding 4-alkyl and 4-dealkyl pyridines . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
153,
168
]
} | {
"id": "C0034255",
"name": "pyridines",
"pos": [
224,
233
]
} |
blood coagulation factor vii is a vitamin k dependent glycoprotein which in its activated form , factor viia , participates in the coagulation process by activating factor x and/or factor ix in the presence of ca2+ and tissue factor . | NA | {
"id": "C0015502",
"name": "blood coagulation factor vii",
"pos": [
0,
28
]
} | {
"id": "C0015505",
"name": "factor viia",
"pos": [
97,
108
]
} |
in the present study , the amino acid sequence and posttranslational modifications of recombinant factor viia as purified from the culture medium of a transfected baby hamster kidney cell line have been compared to human plasma factor viia . | NA | {
"id": "C0534191",
"name": "recombinant factor viia",
"pos": [
86,
109
]
} | {
"id": "C0015505",
"name": "factor viia",
"pos": [
228,
239
]
} |
by use of hplc , amino acid analysis , peptide mapping , and automated edman degradations , the protein backbone of recombinant factor viia was found to be identical with human factor viia . | NA | {
"id": "C0534191",
"name": "recombinant factor viia",
"pos": [
116,
139
]
} | {
"id": "C0015505",
"name": "factor",
"pos": [
177,
183
]
} |
neither recombinant factor viia nor human plasma factor viia was found to contain beta-hydroxyaspartic acid . | NA | {
"id": "C0534191",
"name": "recombinant factor viia",
"pos": [
8,
31
]
} | {
"id": "C0015505",
"name": "factor viia",
"pos": [
49,
60
]
} |
in human plasma factor viia , the 10 n-terminally located glutamic acid residues were found to be fully gamma-carboxylated whereas 9 full and 1 partial gamma-carboxylated residues were found in the corresponding positions of the recombinant factor viia molecule . | NA | {
"id": "C0015505",
"name": "factor viia",
"pos": [
16,
27
]
} | {
"id": "C0534191",
"name": "recombinant factor viia",
"pos": [
229,
252
]
} |
besides minor differences in the sialic acid and fucose contents , the overall carbohydrate compositions were nearly identical in recombinant factor viia and human plasma factor viia . | NA | {
"id": "C0534191",
"name": "recombinant factor viia",
"pos": [
130,
153
]
} | {
"id": "C0015505",
"name": "factor viia",
"pos": [
171,
182
]
} |
further , when the parent cells were treated with a pulse of radiolabeled photoprobe , followed by uv irradiation at different times at 37 degrees c , the probe appeared sequentially on the 48k membrane protein and both the 38k cytosolic protein and dihydrofolate reductase . | NA | {
"id": "C0025252",
"name": "membrane",
"pos": [
194,
202
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
238,
245
]
} |
the boc-protected derivative of a photoactivatable , carbene-generating analogue of phenylalanine , l-4'- [ 3- ( trifluoromethyl ) -3h-diazirin-3-yl ] phenylalanine [ ( tmd ) phe ] , was used to acylate 5'-o-phosphorylcytidylyl ( 3'-5 ' ) adenosine ( pcpa ) . | NA | {
"id": "C0031453",
"name": "phe",
"pos": [
84,
87
]
} | {
"id": "C0030135",
"name": "pcpa",
"pos": [
251,
255
]
} |
rabbit antibodies made against the human erythrocyte glucose transporter were used to determine whether or not embryonic glucose transporters of rat skeletal muscle , liver and brain are identical to the transporters of adult animals . | NA | {
"id": "C0168458",
"name": "erythrocyte glucose transporter",
"pos": [
41,
72
]
} | {
"id": "C0017742",
"name": "glucose transporters",
"pos": [
121,
141
]
} |
experiments carried out with hemin ( ferric iron ) liganded with imidazole or with reduced protoheme ( ferrous iron ) liganded with carbon monoxide , demonstrated that the inhibition requires that hemin be capable of binding additional ligands . | NA | {
"id": "C0018966",
"name": "protoheme",
"pos": [
91,
100
]
} | {
"id": "C0018988",
"name": "hemin",
"pos": [
197,
202
]
} |
both inorganic phosphate and orthovanadate were effective in preventing inactivation by fitc , and calcium only partially reversed the effect of these anions , implying the existence of a ternary complex such as ca2.e.pi . | NA | {
"id": "C0031603",
"name": "inorganic phosphate",
"pos": [
5,
24
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
151,
157
]
} |
chondroitin sulfate , heparin and dextran sulfate were as effective as unlabeled ha in competing for 125i-ha binding to permeabilized hepatocytes , indicating that the binding sites may have a general specificity for glycosaminoglycans . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
22,
29
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
217,
235
]
} |
the interaction of three vitamin a derivatives or retinoids : all-trans-retinoic acid , 13-cis-retinoic acid and retinol with multilamellar phospholipid bilayers was studied using a combination of 2h- and 31p-nmr measurements . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
25,
34
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
50,
59
]
} |
the interaction of three vitamin a derivatives or retinoids : all-trans-retinoic acid , 13-cis-retinoic acid and retinol with multilamellar phospholipid bilayers was studied using a combination of 2h- and 31p-nmr measurements . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
25,
34
]
} | {
"id": "C0040845",
"name": "all-trans-retinoic",
"pos": [
62,
80
]
} |
the interaction of three vitamin a derivatives or retinoids : all-trans-retinoic acid , 13-cis-retinoic acid and retinol with multilamellar phospholipid bilayers was studied using a combination of 2h- and 31p-nmr measurements . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
50,
59
]
} | {
"id": "C0022265",
"name": "13-cis-retinoic acid",
"pos": [
88,
108
]
} |
the depolarizing effect of l-alanine was dependent on external na+ , and was specific for the l-isomer of alanine , as d- and beta-alanine had no effect . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
29,
36
]
} | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
126,
138
]
} |
however , amino acids with hydrocarbon side chains of less than three carbons long , e.g . glycine , alanine , and 2-aminobutyric acid , were cryoprotective only in the presence of salt . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
10,
21
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
91,
98
]
} |
however , amino acids with hydrocarbon side chains of less than three carbons long , e.g . glycine , alanine , and 2-aminobutyric acid , were cryoprotective only in the presence of salt . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
10,
21
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
101,
108
]
} |
thus the internal energy required for carrying the complex between anion and transport protein over the rate-limiting energy barrier is largely compensated for by an increase of randomness in the protein and/or its aqueous environment . | NA | {
"id": "C0007292",
"name": "transport protein",
"pos": [
77,
94
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
196,
203
]
} |
in vitro replication of pt181 was found to generate single-stranded dna in addition to the supercoiled , double-stranded dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
52,
71
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
105,
124
]
} |
such a molecule appeared to be an efficient template and could initiate by the same protein-priming mechanism as double-stranded dna , employing the precursor terminal protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
84,
91
]
} | {
"id": "C0033665",
"name": "precursor",
"pos": [
149,
158
]
} |
preliminary results concerning the transfection of 'normal ' xp fibroblasts with activated ras genes seem to indicate that these cells are as resistant as the healthy controls to the transforming action of the group ii oncogenes . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
64,
75
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
129,
134
]
} |
however , after transfection with v-myb oncogene in xp fibroblasts several cellular clones have been isolated showing some new phenotypic characteristics . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
55,
66
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
75,
83
]
} |
agents that previously have been shown to activate protein kinase c , such as the tumor-promoting phorbol ester , phorbol 12-myristate 13-acetate ( pma ) , and the synthetic diacylglycerol analog , 1-oleoyl-2-acetylglycerol ( oag ) , suppressed luteinizing hormone ( lh ) -induced progesterone ( pma at levels of 10 and ... | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
98,
111
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
114,
121
]
} |
this study demonstrates that the fs and odf , both composed of many polypeptides , several having similar molecular weights , are related cytoskeletal structures as they have epitopes in common , and both contain 14.4 kda polypeptides with common antigenic and electrophoretic properties . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
175,
183
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
247,
256
]
} |
several of the phospholipases tested , including phospholipases c , d , and a2 , had no inhibitory effect on sperm penetration levels , with phospholipase c and a2 ( 100 micrograms/ml ) causing inhibition of sperm attachment . | NA | {
"id": "C0031671",
"name": "phospholipases",
"pos": [
15,
29
]
} | {
"id": "C1956229",
"name": "phospholipases c",
"pos": [
49,
65
]
} |
we propose that 22:6 , or a metabolite of 22:6 , may regulate free fatty acid utilization in human sperm and that this hypothesis may provide an enzymatic explanation for the changes observed in phospholipid-bound fatty acids during the epididymal maturation of sperm . | NA | {
"id": "C0015688",
"name": "free fatty",
"pos": [
62,
72
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
214,
225
]
} |
cells pretreated with medium alone showed a dose-dependent increase in medium lh immunoreactivity , but the alpha and lh beta mrnas showed no change over the 4-h period . | NA | {
"id": "C0023607",
"name": "lh",
"pos": [
78,
80
]
} | {
"id": "C0065261",
"name": "lh beta",
"pos": [
118,
125
]
} |
when added to a red cell suspension the ion crosses the cell membrane rapidly , via the anion exchange protein , and the intra- and extracellular populations of the ion give rise to separate 31p nmr resonances . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
88,
93
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
165,
168
]
} |
the translational mobility of fluorescent-labeled monoclonal antibodies specifically bound to supported phospholipid bilayers containing hapten-conjugated phospholipids has been measured as a function of the surface concentration of bound antibodies using fluorescence recovery after photobleaching . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
50,
71
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
239,
249
]
} |
the peculiarity of this copolymer was proved by investigating the interactions of dppg vesicles with polylysine-tryptophan 4:1 , polyornithine-lysine 4:1 and polylysine-tyrosine 1:1 . | NA | {
"id": "C0024337",
"name": "lysine",
"pos": [
105,
111
]
} | {
"id": "C0032518",
"name": "polylysine",
"pos": [
158,
168
]
} |
a 2h-nmr study of the a-dna conformation in films of oriented na-dna : evidence of a disordered b-dna contribution . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
98,
101
]
} |
all antisera produced in rabbits , rats or mice contained antibodies that were specific to the deglycosylated hormones with the native hormones showing weak and non-parallel cross-reaction ( less than 5 % ) , but with rabbit antibodies to native hormones the deglycosylated hormones were fully reactive . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
4,
12
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
225,
235
]
} |
the results of the immunoblotting experiments and elisa suggest the existence of at least two proteins ( 65 and 59 kda ) which are immunologically related to the nuclear lamina proteins of higher eukaryotes . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
94,
102
]
} | {
"id": "C0028589",
"name": "nuclear",
"pos": [
162,
169
]
} |
in the positive ion mode , the base peak was [ m + nh4 ] + for all the studied compounds , while in the negative ion mode the organophosphorus pesticides exhibited different fragmentation behaviour , such as electron capture , dissociative electron capture and anion attachment . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
16,
19
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
261,
266
]
} |
in the positive ion mode , detection limits at the low nanogram level were achieved for the trialkyl and triaryl phosphates , similar to gas chromatography/positive chemical ionization mass spectrometry with ammonia as reagent gas . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
208,
215
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
227,
230
]
} |
aids has now become a major global pandemic , and vaccine and therapeutic strategies are urgently being investigated in an effort to control the disease . | NA | {
"id": "C0039082",
"name": "aids",
"pos": [
0,
4
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
145,
152
]
} |
in view of the fact that experiments in animal models of human disease suggest that antileukemic effects of allogeneic marrow grafts may be partially independent of gvhd , new approaches for amplification of antitumor effects of autologous and allogeneic cells by cytokines and by lymphokine-activated cells are discusse... | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
244,
260
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
302,
307
]
} |
disaggregated chondrocytes from embryonic chick whole sterna proliferate in three-dimensional collagen gels forming mixtures of cartilage nodules ( chondroids ) and columns of cells . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
14,
26
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
176,
181
]
} |
it is concluded that caffeine , other alkylated xanthines and xanthine itself share a spasmogenic action in guinea-pig isolated trachealis which is best observed when the tissue is treated with indomethacin ( 2.8 microm ) and maintained at 12 degrees c . | NA | {
"id": "C0006644",
"name": "caffeine",
"pos": [
21,
29
]
} | {
"id": "C0043318",
"name": "xanthines",
"pos": [
48,
57
]
} |
it is concluded that caffeine , other alkylated xanthines and xanthine itself share a spasmogenic action in guinea-pig isolated trachealis which is best observed when the tissue is treated with indomethacin ( 2.8 microm ) and maintained at 12 degrees c . | NA | {
"id": "C0043318",
"name": "xanthines",
"pos": [
48,
57
]
} | {
"id": "C0043314",
"name": "xanthine",
"pos": [
62,
70
]
} |
the data suggest that monocrotaline-induced lung injury impairs the metabolism of pge2 during pulmonary circulation but has little effect on the conversion of ai to aii and the degradation of bradykinin in rats . | NA | {
"id": "C0003018",
"name": "ai",
"pos": [
59,
61
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
165,
168
]
} |
other substituted benzamides including metoclopramide , sulpiride , tiapride , sultopride and cisapride were inactive at 10 ( -5 ) m . | NA | {
"id": "C0005029",
"name": "benzamides",
"pos": [
18,
28
]
} | {
"id": "C0025853",
"name": "metoclopramide",
"pos": [
39,
53
]
} |
other substituted benzamides including metoclopramide , sulpiride , tiapride , sultopride and cisapride were inactive at 10 ( -5 ) m . | NA | {
"id": "C0005029",
"name": "benzamides",
"pos": [
18,
28
]
} | {
"id": "C0038803",
"name": "sulpiride",
"pos": [
56,
65
]
} |
other substituted benzamides including metoclopramide , sulpiride , tiapride , sultopride and cisapride were inactive at 10 ( -5 ) m . | NA | {
"id": "C0005029",
"name": "benzamides",
"pos": [
18,
28
]
} | {
"id": "C0072916",
"name": "cisapride",
"pos": [
94,
103
]
} |
we examined the possibility that the neuropeptide , galanin , may act as a transmitter in longitudinal muscle isolated from the rat ileum . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
37,
49
]
} | {
"id": "C0060993",
"name": "galanin",
"pos": [
52,
59
]
} |
similar apparent pa2 values for nadolol at the putative adrenoceptor were obtained with noradrenaline ( 4.79 ) , adrenaline ( 4.68 ) , and fenoterol ( 4.38 ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
88,
101
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
113,
123
]
} |
the order and relative potency of agonists at the putative adrenoceptor was : brl 37344 ( 20 ) greater than ( - ) -isoprenaline ( 8 ) greater than noradrenaline ( 1 ) greater than adrenaline ( 0.5 ) greater than fenoterol ( 0.35 ) greater than ( + ) -isoprenaline ( 0.27 ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
147,
160
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
180,
190
]
} |
only glucose derivatives with a sufficiently bulky substituent in position c-2 , such as the glucokinase substrates glucose and mannose and the inhibitors mannoheptulose , glucosamine , and n-acetylglucosamine , protected glucokinase against inhibition by alloxan by binding to the active site of the enzyme . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
172,
183
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
190,
209
]
} |
the membrane was hyperpolarized by the opioid peptides tyr-d-ala-gly-mephe-gly-ol ( dagol , 0.01-1 microm ) and [ met5 ] enkephalin ( 3-30 microm ) , though not by tyr-d-pen-gly-phe-d-pen and u50488 . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
39,
54
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
121,
131
]
} |
the membrane was hyperpolarized by the opioid peptides tyr-d-ala-gly-mephe-gly-ol ( dagol , 0.01-1 microm ) and [ met5 ] enkephalin ( 3-30 microm ) , though not by tyr-d-pen-gly-phe-d-pen and u50488 . | NA | {
"id": "C0525773",
"name": "dagol",
"pos": [
84,
89
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
121,
131
]
} |
at protective doses , verapamil , gallopamil , and nimodipine significantly raised the respiration rate but had little or no cardiac depressor effects . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
22,
31
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
34,
44
]
} |
comparison of a low molecular weight heparin and unfractionated heparin for the prevention of deep vein thrombosis in patients undergoing abdominal surgery . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
16,
44
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
64,
71
]
} |
in a prospective , randomized multicentre trial the efficacy and safety of the low molecular weight heparin ( lmwh ) fraction fraxiparin and unfractionated calcium heparin ( calciparin ) were compared for the prevention of postoperative deep vein thrombosis . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
79,
107
]
} | {
"id": "C0019134",
"name": "unfractionated",
"pos": [
141,
155
]
} |
a patient is presented who died 10 days after she had developed prosopagnosia , topographagnosia and an agnosia for real objects seen from noncanonical views . | NA | {
"id": "C0234512",
"name": "prosopagnosia",
"pos": [
64,
77
]
} | {
"id": "C0001816",
"name": "agnosia",
"pos": [
104,
111
]
} |
previous studies on the transduction mechanisms triggered by dopamine receptor stimulation have established that both d1 and d2 subtypes of dopamine receptors are linked to the adenylate cyclase system , the former in a stimulatory and the latter in an inhibitory manner . | NA | {
"id": "C0034798",
"name": "dopamine receptor",
"pos": [
61,
78
]
} | {
"id": "C0058698",
"name": "d2",
"pos": [
125,
127
]
} |
recent iontophoretic data suggest that conversion of angiotensin ii ( aii ) to angiotensin iii ( aiii ) may be necessary before the peptide can activate central angiotensin-sensitive neurons . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
53,
67
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
161,
172
]
} |
recent iontophoretic data suggest that conversion of angiotensin ii ( aii ) to angiotensin iii ( aiii ) may be necessary before the peptide can activate central angiotensin-sensitive neurons . | NA | {
"id": "C0003012",
"name": "angiotensin iii",
"pos": [
79,
94
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
161,
172
]
} |
pressor responses induced by the aminopeptidase-resistant analogue , [ sar1 ] angiotensin ii , were not affected by pretreatment with angiotensin inhibitors . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
78,
92
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
134,
145
]
} |
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