text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the active phorbol ester 12-o-tetradecanoyl-phorbol-beta-acetate ( tpa ) , and to a lesser extent sn-1,2-dioctanoylglycerol ( dag ) , triggered trh release . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
11,
24
]
} | {
"id": "C0039654",
"name": "tetradecanoyl-phorbol",
"pos": [
30,
51
]
} |
using the isolated guinea pig ileum the ltc4-like material was shown to possess biological activity which could be antagonized with the slow-reacting substance of anaphylaxis ( srs-a ) antagonist fpl 55712 . | NA | {
"id": "C0023542",
"name": "ltc4",
"pos": [
40,
44
]
} | {
"id": "C0038091",
"name": "slow-reacting substance of anaphylaxis",
"pos": [
136,
174
]
} |
adenosine , adenosine triphosphate ( atp ) and the purine analogues n-ethylcarboxamide adenosine ( neca ) and r- and s-phenylisopropyladenosine ( pia ) reduced the effects of carbachol on single cell firing and on the population spike . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
0,
9
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
119,
143
]
} |
the rank order of potency for the purine reduction of carbachol responses was r-pia = s-pia = neca much greater than adenosine greater than atp . | NA | {
"id": "C0031484",
"name": "pia",
"pos": [
80,
83
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
117,
126
]
} |
the rank order of potency for the purine reduction of carbachol responses was r-pia = s-pia = neca much greater than adenosine greater than atp . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
117,
126
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
140,
143
]
} |
galanin , a recently described brain-gut neuropeptide , exists in central nervous pathways subserving cardiovascular regulation in the rat . | NA | {
"id": "C0060993",
"name": "galanin",
"pos": [
0,
7
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
41,
53
]
} |
immunohistologic localization of tyrosine hydroxylase ( toh ) , dopamine-beta-hydroxylase ( dbh ) and selected neuropeptides ( vasoactive intestinal polypeptide , gastrin-releasing peptide ( grp ) /bombesin , substance p , leu-enkephalin , met-enkephalin , dynorphin b , neuropeptide y ( npy ) , somatostatin ) was used ... | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
111,
124
]
} | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
271,
285
]
} |
patterns of cortical connections were studied in brain sections cut parallel to the surface of mechanically flattened cortex after single , double , or multiple injections of wheatgerm agglutinin conjugated to horseradish peroxidase ( wga-hrp ) in area 17 of galagos ( galago crassicaudatus ) . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
210,
232
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
235,
242
]
} |
an inhibition test on the kidney section showed that the reactivity of moab am34 was not at all inhibited by the pretreatment of the section with 10 times higher concentration of anti-human amyloid a ( aa ) moab km268 which was prepared against synthetic peptides of aa protein , suggesting that moab am34 might react wi... | NA | {
"id": "C0002716",
"name": "amyloid",
"pos": [
190,
197
]
} | {
"id": "C1456454",
"name": "amyloid",
"pos": [
323,
330
]
} |
finally , gaba was found to stimulate the release of the opioid peptides beta-endorphin , dynorphin and met-enkephalin . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
57,
72
]
} | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
90,
99
]
} |
in contrast , all cells which display a fibroblastic morphology , as well as clear epithelial cells are m2-pk positive , but l-pk negative . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
18,
23
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
40,
52
]
} |
monovalent antibodies ( fab ) prepared from rabbit antiserum against a crude membrane preparation of fusion-competent hm1 cells inhibited fusion between hm1 and nc4 cells . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
11,
21
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
51,
60
]
} |
however , these differentiating subclones and nondifferentiating fibroblasts that exhibit a normal karyotype will be an excellent model-system to investigate the molecular basis of cell lineage determination . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
65,
76
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
158,
161
]
} |
it is concluded that the ecm of these organs can organize for proper developmental function in the absence of the major interstitial collagen , but a possible morphogenetic function of other fibrillar collagens ( types iii and v ) can not be excluded . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
133,
141
]
} | {
"id": "C0969669",
"name": "fibrillar",
"pos": [
191,
200
]
} |
treatments of penile and preputial injuries , anomalies , tumors , `` '' summer sores , '' '' paraphimosis , phimosis , and priapism are presented . | NA | {
"id": "C0030483",
"name": "paraphimos",
"pos": [
94,
104
]
} | {
"id": "C0031538",
"name": ", phimos",
"pos": [
107,
115
]
} |
clinical signs of hypocalcemia in beef cattle , sheep , and goats tend toward hyperesthesia and tetany rather than the classic flaccid paralysis that occurs in dairy cattle with parturient hypocalcemia . | NA | {
"id": "C0039621",
"name": "tetany",
"pos": [
96,
102
]
} | {
"id": "C0020598",
"name": "hypocalcemia",
"pos": [
189,
201
]
} |
of the personnel tested , 36 ( 8.3 % ) had the neutralizing antibody to jamestown canyon but not snowshoe hare virus , 6 ( 1.4 % ) had the antibody to snowshoe hare but not jamestown canyon virus , 53 ( 12.2 % ) had the antibody to both viruses , 17 ( 3.9 % ) had the antibody to northway virus , and 15 ( 3.4 % ) had th... | NA | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
47,
68
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
322,
330
]
} |
of the personnel tested , 36 ( 8.3 % ) had the neutralizing antibody to jamestown canyon but not snowshoe hare virus , 6 ( 1.4 % ) had the antibody to snowshoe hare but not jamestown canyon virus , 53 ( 12.2 % ) had the antibody to both viruses , 17 ( 3.9 % ) had the antibody to northway virus , and 15 ( 3.4 % ) had th... | NA | {
"id": "C0003253",
"name": "antibody",
"pos": [
60,
68
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
322,
330
]
} |
the results of this study suggest that the lipid a segment of the lps molecule of ed . ictaluri is similar to s. typhimurium and e. coli , at least with respect to fatty acid content ; | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
43,
50
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
66,
69
]
} |
some mesophilic yeasts and a thermotolerant strain of saccharomyces cerevisiae were found to grow at 40 degrees c in complex media containing 1 % yeast extract when an inoculum of 10 ( 6 ) or more cells.ml-1 was used . | NA | {
"id": "C0043393",
"name": "yeasts",
"pos": [
16,
22
]
} | {
"id": "C0873195",
"name": "yeast extract",
"pos": [
146,
159
]
} |
changes in anticonvulsant serum levels during intercurrent illness may cause toxicity or decreased seizure control in children with epilepsy . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
99,
106
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
132,
140
]
} |
forty-eight [ 9.3 % ] of the patients had significant gastrointestinal bleeding , the distribution of which was as follows : hematemesis [ 37/518 ] , melena [ 11/518 ] and/or hematochezia [ 4/518 ] . | NA | {
"id": "C0017181",
"name": "gastrointestinal bleeding",
"pos": [
54,
79
]
} | {
"id": "C0018926",
"name": "hematemesis",
"pos": [
125,
136
]
} |
forty-eight [ 9.3 % ] of the patients had significant gastrointestinal bleeding , the distribution of which was as follows : hematemesis [ 37/518 ] , melena [ 11/518 ] and/or hematochezia [ 4/518 ] . | NA | {
"id": "C0017181",
"name": "gastrointestinal bleeding",
"pos": [
54,
79
]
} | {
"id": "C0025222",
"name": "melena",
"pos": [
150,
156
]
} |
in this model gliosis is not involved in the development of epilepsy , nor does it result from repeated seizures . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
60,
68
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
104,
112
]
} |
of 115 cases , 10 presented with a lacunar syndrome : 3 presented with pure motor hemiparesis , 1 , pure sensory stroke , 1 , ataxic hemiparesis , 5 , sensorimotor stroke , and , none , dysarthria -- clumsy hand syndrome . | NA | {
"id": "C3178801",
"name": "lacunar syndrome",
"pos": [
35,
51
]
} | {
"id": "C0038454",
"name": "stroke",
"pos": [
164,
170
]
} |
sperm locomotion is inhibited in a concentration-dependent fashion when cells are bathed with soluble antimembrane protein monoclonal antibodies but not with antimouse ig antibodies or a monoclonal antibody against a sperm cytoplasmic protein . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
134,
144
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
187,
206
]
} |
our results suggest that c. elegans sperm crawl by gaining traction with substrate-attached ligands via their surface proteins and by using the motor that moves those proteins rearward on unattached cells to pull the entire cell forward . | NA | {
"id": "C0025252",
"name": "surface proteins",
"pos": [
110,
126
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
167,
175
]
} |
the bulk of the 3h not recovered in bile at 49 h after the injection of the labeled chylomicrons was recovered in blood and tissues and almost all ( integral of 94 % ) of this material was associated with chol and chol esters . | NA | {
"id": "C0008377",
"name": "chol",
"pos": [
205,
209
]
} | {
"id": "C0008387",
"name": "chol esters",
"pos": [
214,
225
]
} |
the selective delivery of i to liver as its oleate ester in chylomicrons ( or , more probably , as chylomicron remnants ) and the subsequent metabolism of the oleate ester of i in liver has important consequences with respect to the actions of i which are discussed herein . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
60,
72
]
} | {
"id": "C0443616",
"name": "chylomicron remnants",
"pos": [
99,
119
]
} |
neutralizing antibodies alone were found in 22 % ( 14/63 ) and adcc antibodies alone in 6 % ( 4/63 ) of the sera tested . | NA | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
0,
23
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
68,
78
]
} |
thirty-seven per cent ( 23/63 ) of the sera were negative for both types of antibodies , 62 % of the sera with neutralizing antibodies also had adcc inducing antibodies and 85 % of the sera with adcc antibodies had neutralizing antibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
76,
86
]
} | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
215,
238
]
} |
compared to levels of il-1 mrna found in optimally activated normal blood mononuclear cells , the levels of il-1 alpha mrna were high in seven of the nine patients studied , whereas il-1 beta mrna , the dominant form in blood , was relatively lower . | NA | {
"id": "C0021755",
"name": "il-1",
"pos": [
22,
26
]
} | {
"id": "C0600251",
"name": "il-1",
"pos": [
182,
186
]
} |
cultures of rheumatoid joint cells produced il-1 bioactivity , with roughly equal amounts of il-1 alpha and beta , as assessed using neutralizing antibodies . | NA | {
"id": "C0021755",
"name": "il-1",
"pos": [
44,
48
]
} | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
93,
103
]
} |
though complement activation is recognized as a central event in inflammation in the rheumatoid joint , little attention has been paid to the role of the cytolytic membrane attack complex of complement in the pathogenesis of this disease . | NA | {
"id": "C0009545",
"name": "cytolytic membrane attack complex",
"pos": [
154,
187
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
191,
201
]
} |
the expression of genetic influences upon mast cell response phenotype appears to be at both the level of mast cell precursor cells , as determined from limiting dilution assays of bm from high , low and f1 ( high x low ) strains , and at the level of mast cell proliferation , as determined by repeated sub-culture of m... | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
116,
131
]
} |
although ondine 's curse following viral infection of the central nervous system has been previously reported this represents the first case of viral encephalitis to be pathologically documentated . | NA | {
"id": "C0348165",
"name": "viral infection of",
"pos": [
35,
53
]
} | {
"id": "C0243010",
"name": "viral encephalitis",
"pos": [
144,
162
]
} |
application of the full weight of the available technology results in only a few infants of less than 23 to 24 weeks ' gestation or with birth weights of less than 500 to 600 gm surviving . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
24,
30
]
} | {
"id": "C0005612",
"name": "birth weights",
"pos": [
137,
150
]
} |
adriamycin ( adr ) , selectively toxic to glomerular epithelial cells , was administered ( 5 mg/kg bw , i.v . ) to mwf/ztm rats to study its early effects on glomerular barrier function with respect to albumin and high molecular weight ( hmw ) proteins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
202,
209
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
244,
252
]
} |
because urinary prostaglandin excretion could play a role in idiopathic hypercalciuria ( ih ) , we studied the excretion of prostaglandin e ( pge ) , calcium and sodium at various urine flows in 21 patients ( 14 males ) with urolithiasis and ih , seven stone formers ( five males ) with normal calciuria and 20 controls ... | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
16,
29
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
124,
139
]
} |
the present study examined the effect of an infusion of the dipeptide alanylglutamine or of the corresponding amino acids alanine and glutamine in equimolar amounts ( 10 mumol min-1 kg-1 ) on the canine hindlimb exchange of alanine and glutamine in the post-operative anaesthetized dog . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
110,
121
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
224,
231
]
} |
this study demonstrates that during short-term administration of alanylglutamine or of the corresponding amino acids the nitrogen release from the hindlimb of the anaesthetized post-operative dog via alanine and glutamine is reduced . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
105,
116
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
200,
207
]
} |
the disruption of normal bowel flora can result in diarrhea , pseudomembranous colitis , and systemic infections or sepsis in immunocompromised patients . | NA | {
"id": "C0243026",
"name": "systemic infections",
"pos": [
93,
112
]
} | {
"id": "C0036690",
"name": "sepsis",
"pos": [
116,
122
]
} |
the effects on lipids were characterized by a non-significant increase of total cholesterol and a significant increase of hdl-c , hdl2-c and apo-al lipoproteins , which were somewhat more pronounced during d-50 treatment . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
15,
21
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
148,
160
]
} |
the orally available beta-lactam antibiotics , cephalexin and cephradine , were not enhanced in their enteral or rectal absorption by capmul in the two model systems . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
47,
57
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
62,
72
]
} |
blood combined with subinhibitory ( 1/2 mic ) concentrations of aztreonam , ceftazidime , ciprofloxacin , fleroxacin , imipenem , and tobramycin , respectively , yielded additive effects ; | NA | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
90,
103
]
} | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
106,
116
]
} |
in a second part of the study the susceptibility to augmentin of 4.137 gram-negative and 10.958 gram-positive pathogens was compared to their sensitivity against benzylpenicillin , flucloxacillin , mezlocillin , erythromycin , clindamycin , fusidic acid , ampicillin , cefaclor and doxycyclin . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
162,
178
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
256,
266
]
} |
in a second part of the study the susceptibility to augmentin of 4.137 gram-negative and 10.958 gram-positive pathogens was compared to their sensitivity against benzylpenicillin , flucloxacillin , mezlocillin , erythromycin , clindamycin , fusidic acid , ampicillin , cefaclor and doxycyclin . | NA | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
198,
209
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
256,
266
]
} |
the conclusion is that aids has invaded taiwan , but the prevalence of the hiv infection is presently low . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
23,
27
]
} | {
"id": "C0019693",
"name": "hiv",
"pos": [
75,
78
]
} |
the lack of correlation between 24 hour respiratory quotient measured in a metabolic chamber ( a measure of the proportion of fat derived calories ) and degree of obesity indicates that in obese pima indians insulin resistance is not due to an inhibition of glucose metabolism by free fatty acids ( glucose-fatty acid-ke... | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
280,
296
]
} | {
"id": "C0015684",
"name": "fatty",
"pos": [
307,
312
]
} |
since the dna sequences flanking the insert are identical between clones coding for the two precursor protein , we suggest mrnas coding for these proteins arise via differential splicing . | NA | {
"id": "C0033665",
"name": "precursor protein",
"pos": [
92,
109
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
146,
154
]
} |
transfer experiments were carried out by the following schedule : sst-2 cells were inoculated intravenously on day 0 , irradiated allogeneic spleen cells were transferred intravenously on day -5 , 1 and 8 , and lak cells were transferred on day 2 , 5 and 7 . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
72,
77
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
130,
140
]
} |
the pa2 values characterising the potencies were roxatidine acetate 6.85 +/- 0.86 , roxatidine 7.14 +/- 0.04 , and ranitidine 6.92 +/- 0.01 . | NA | {
"id": "C0073601",
"name": "roxatidine acetate",
"pos": [
49,
67
]
} | {
"id": "C0378091",
"name": "0",
"pos": [
137,
138
]
} |
schild-plot slopes of roxatidine acetate and ranitidine were not significantly different from unity and pa2 values were similar to those of the adenylate cyclase inhibition , roxatidine acetate 7.15 +/- 0.09 , roxatidine 7.03 +/- 0.02 , and ranitidine 6.83 +/- 0.10 . | NA | {
"id": "C0073601",
"name": "roxatidine acetate",
"pos": [
22,
40
]
} | {
"id": "C0378091",
"name": "0",
"pos": [
264,
265
]
} |
this paper reviews those studies which investigated the absorption , distribution , metabolism and elimination of roxatidine acetate ( formerly hoe 760 ) following its single and multiple oral administration to healthy male and female volunteers . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
84,
94
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
99,
110
]
} |
in addition , roxatidine acetate 75 mg daily did not modify the clearance of propranolol , diazepam , desmethyldiazepam or controlled release theophylline preparations . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
91,
99
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
102,
119
]
} |
[ modifying effect of ascorbic acid and sodium ascorbate on uterine carcomogenesis induced by 1,2-dimethylhydrazine in cba mice ] . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
22,
35
]
} | {
"id": "C0887557",
"name": "sodium ascorbate",
"pos": [
40,
56
]
} |
according to her body weight change , the observation period was divided into 3 stages : initial emaciation ( stage 1 ) , stable maintenance of the -30 % level of the previous weight ( stage 2 ) and convalescent stage ( stage 3 ) . | NA | {
"id": "C0005911",
"name": "body weight change",
"pos": [
17,
35
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
176,
182
]
} |
stage 1 was characterized by relatively high urinary norepinephrine ( ne ) and epinephrine ( e ) but low dopamine ( da ) excretion , elevated plasma da-beta-hydroxylase ( dbh ) activity and reduced serum thyroid hormones , especially the triiodothyronine ( t3 ) level . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
53,
67
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
79,
90
]
} |
we conclude that the viscosity of the fluid bounding the lipid bilayers is of minor importance for the diffusion of membrane lipids . | NA | {
"id": "C0023768",
"name": "lipid bilayers",
"pos": [
57,
71
]
} | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
116,
131
]
} |
spectral shifts associated with red-edge excitation are observed for proteins emitting in the medium spectral range - human serum albumin in the n and f forms , it-aj1 protease inhibitor at ph 2.9 , melittin at high ionic strength as well as the albumin-dodecyl-sulfate complex . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
69,
77
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
246,
253
]
} |
spectral shifts associated with red-edge excitation are observed for proteins emitting in the medium spectral range - human serum albumin in the n and f forms , it-aj1 protease inhibitor at ph 2.9 , melittin at high ionic strength as well as the albumin-dodecyl-sulfate complex . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
118,
137
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
246,
253
]
} |
orientation measurements on membrane systems made from lipopolysaccharides and free lipid a by ft-ir spectroscopy . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
55,
74
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
84,
91
]
} |
here we report on investigations into the orientational behaviour of hydrated membrane systems made from lipopolysaccharide and its lipid component , free lipid a , using fourier-transform infrared spectroscopy and applying attenuated total reflectance . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
105,
123
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
155,
162
]
} |
the observed structural preferences might be of great importance with respect to the expression of biological activities of lipopolysaccharide and free lipid a systems in vivo and in vitro . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
124,
142
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
152,
159
]
} |
electrical stimulation of the cervical vagus nerve produces a similar response , presumably by releasing substance p or other tachykinins from sensory nerve endings . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
105,
116
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
126,
137
]
} |
with oxidant stress , gsh acts to protect cell constituents as evidenced by increased turnover to gssg , formation of mixed disulfides with proteins , utilization of nadph , and utilization of glucose in the pentose pathway . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
22,
25
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
98,
102
]
} |
because high partial pressures of oxygen ( o2 ) can cause peroxidative cleavage of membrane lipids , it is plausible to hypothesize that hyperoxia alters the physical state and composition of lipids in the membranes of pulmonary endothelial cells and that manipulation of the lipid profile may modify endothelial cell to... | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
83,
98
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
276,
281
]
} |
treatment of adult rats with low doses of bacterial lipopolysaccharide ( endotoxin ) consistently results in a marked protective effect against o2-induced lung damage and lethality . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
52,
70
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
73,
82
]
} |
two proteins co-operate in the proteolytic cleavage of mitochondrial precursor proteins : the mitochondrial processing peptidase ( mpp ) and the processing enhancing protein ( pep ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
4,
12
]
} | {
"id": "C0949610",
"name": "mitochondrial",
"pos": [
94,
107
]
} |
fractionation of small nuclear ribonucleoprotein particles from heat-shock extracts by native polyacrylamide gel electrophoresis reveals dramatic changes in certain particles , most noticeably in a u4/u5/u6 snrnp complex and the u2 snrnp . | NA | {
"id": "C0142661",
"name": "small nuclear ribonucleoprotein particles",
"pos": [
17,
58
]
} | {
"id": "C0162796",
"name": "u2 snrnp",
"pos": [
229,
237
]
} |
mas2 encodes an essential 53-kd protein that is located in the mitochondrial matrix and is homologous to the mas1 protein , a previously identified subunit of the protease that cleaves presequences from mitochondrial precursor proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
32,
39
]
} | {
"id": "C0949610",
"name": "mitochondrial",
"pos": [
203,
216
]
} |
fs9 mouse sarcoma cells were previously shown to be highly invasive when confronted with chicken heart fibroblasts using abercrombie 's confronted explant technique . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
18,
23
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
103,
114
]
} |
to our knowledge , this is the first report in which fidelity of aminoacyl-trna synthetase of animals of various ages has been compared using natural amino acids . | NA | {
"id": "C0035714",
"name": "aminoacyl-trna",
"pos": [
65,
79
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
150,
161
]
} |
beta-galactosidase from saccharomyces lactis has been purified to serve as a model for the kinetic behavior of human lactase in adult lactase deficiency . | NA | {
"id": "C0005220",
"name": "beta-galactosidase",
"pos": [
0,
18
]
} | {
"id": "C0083183",
"name": "lactase",
"pos": [
134,
141
]
} |
enzymes from both species are neutral and follow michaelis-menten kinetics . beta-galactosidase of s. lactis is more readily available than the human lactase . | NA | {
"id": "C0005220",
"name": "beta-galactosidase",
"pos": [
77,
95
]
} | {
"id": "C0083183",
"name": "lactase",
"pos": [
150,
157
]
} |
the effects of the dihydropyridine calcium channel antagonists , nitrendipine and nimodipine , on convulsions produced by different mechanisms have been studied in rats . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium channel antagonists",
"pos": [
19,
62
]
} | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
82,
92
]
} |
3- ( 2-carboxypiperazin-4-yl ) propyl-1-phosphonic acid ( cpp ) , a novel antagonist at the n-methyl-d-aspartate ( nmda ) -preferring subtype of excitatory amino acid receptor , was evaluated in four rodent models of epilepsy , i.e . maximal electroshock seizures and pentylenetetrazol ( ptz ) -induced seizures in mice ... | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
255,
263
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
322,
331
]
} |
this ability to prevent kyn inhibition of release was shared by other amino acids with the following order of potency : glycine greater than d-serine greater than d-alanine much greater than l-serine greater than or equal to l-alanine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
70,
81
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
120,
127
]
} |
this ability to prevent kyn inhibition of release was shared by other amino acids with the following order of potency : glycine greater than d-serine greater than d-alanine much greater than l-serine greater than or equal to l-alanine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
70,
81
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
227,
234
]
} |
glycine and d-serine had no effect on the inhibition of nmda-stimulated [ 3h ] ne release produced by d-2-amino-5-phosphonovaleric acid , mk-801 or mg2+ . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
0,
7
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
106,
111
]
} |
a comparison of the effects of bradykinin ( bk ) , sigma-cyclo-bk and sigma-cyclo-kallidin ( sigma-cyclo-kd ) to induce oedema , hyperalgesia and blood flow in the rat paw was made . | NA | {
"id": "C0006100",
"name": "bk",
"pos": [
44,
46
]
} | {
"id": "C0022474",
"name": "kallidin",
"pos": [
82,
90
]
} |
the effects of ro 15-4513 , fg 7142 and beta-ccm on the activity of the mesocortical dopaminergic system were examined by measuring the changes in the content of the principal dopamine ( da ) metabolite , dihydroxyphenylacetic acid ( dopac ) in the prefrontal cortex of the rat . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
85,
97
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
176,
184
]
} |
the distribution of anterogradely-labeled fibers and retrogradely-labeled cell bodies in the interpeduncular nucleus ( ipn ) was mapped after injections of wheat-germ agglutinin conjugated to horseradish peroxidase ( wga-hrp ) into various structures of the basal forebrain in adult rats . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
192,
214
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
217,
224
]
} |
the doses of the agents possessing equal choline blocking activity provide different levels of protection at chlorophos-induced intoxication of animals that is not observed at carbacholine-induced intoxication . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
41,
48
]
} | {
"id": "C0006945",
"name": "carbacholine",
"pos": [
176,
188
]
} |
twelve new fluoroquinolones , structurally related to norfloxacin , have been synthesized in order to investigate the effect of substituents at the secondary nitrogen of the piperazine ring on antimicrobial activity . | NA | {
"id": "C0949665",
"name": "fluoroquinolones",
"pos": [
11,
27
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
54,
65
]
} |
plasma progesterone ( p4 ) , plasma 20 alpha dihydroprogesterone ( 20 alpha ohp4 ) , in vitro production of pregnenolone ( p5 ) from endogenous cholesterol in ovarian mitochondria ( 8,000 x g pellet ; mt ) , activities of 3 beta hydroxysteroid dehydrogenase ( 3 beta hsd ) in ovarian microsome ( 105,000 x g pellet ; ms ... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
7,
19
]
} | {
"id": "C0012311",
"name": "20 alpha dihydroprogesterone",
"pos": [
36,
64
]
} |
guanine nucleotides reduced the binding of 125i-cck-octapeptide ( cck8 ) to acinar cell membranes , with the rank order of potency being guanyl-5'-yl imidodiphosphate ( gpp ( nh ) p ) greater than gtp greater than gdp greater than gmp . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
0,
19
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
197,
200
]
} |
guanine nucleotides reduced the binding of 125i-cck-octapeptide ( cck8 ) to acinar cell membranes , with the rank order of potency being guanyl-5'-yl imidodiphosphate ( gpp ( nh ) p ) greater than gtp greater than gdp greater than gmp . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
0,
19
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
214,
217
]
} |
guanine nucleotides reduced the binding of 125i-cck-octapeptide ( cck8 ) to acinar cell membranes , with the rank order of potency being guanyl-5'-yl imidodiphosphate ( gpp ( nh ) p ) greater than gtp greater than gdp greater than gmp . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
0,
19
]
} | {
"id": "C0018346",
"name": "gmp",
"pos": [
231,
234
]
} |
guanine nucleotides reduced the binding of 125i-cck-octapeptide ( cck8 ) to acinar cell membranes , with the rank order of potency being guanyl-5'-yl imidodiphosphate ( gpp ( nh ) p ) greater than gtp greater than gdp greater than gmp . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
169,
181
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
197,
200
]
} |
in the present study , the effects of o , p'-ddd on plasma cortisol , pregnenolone , 17 alpha-hydroxypregnenolone ( 17-oh-pregnenolone ) , progesterone , 17 alpha-hydroxyprogesterone ( 17-oh-progesterone ) , 11-deoxycorticosterone ( doc ) , corticosterone , dehydroepiandrosterone ( dhea ) , delta 4-androstenedione ( an... | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
70,
82
]
} | {
"id": "C0376260",
"name": "17-oh-pregnenolone",
"pos": [
116,
134
]
} |
in the present study , the effects of o , p'-ddd on plasma cortisol , pregnenolone , 17 alpha-hydroxypregnenolone ( 17-oh-pregnenolone ) , progesterone , 17 alpha-hydroxyprogesterone ( 17-oh-progesterone ) , 11-deoxycorticosterone ( doc ) , corticosterone , dehydroepiandrosterone ( dhea ) , delta 4-androstenedione ( an... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
139,
151
]
} | {
"id": "C0020387",
"name": "17-oh-progesterone",
"pos": [
185,
203
]
} |
in the present study , the effects of o , p'-ddd on plasma cortisol , pregnenolone , 17 alpha-hydroxypregnenolone ( 17-oh-pregnenolone ) , progesterone , 17 alpha-hydroxyprogesterone ( 17-oh-progesterone ) , 11-deoxycorticosterone ( doc ) , corticosterone , dehydroepiandrosterone ( dhea ) , delta 4-androstenedione ( an... | NA | {
"id": "C0045010",
"name": "17",
"pos": [
85,
87
]
} | {
"id": "C0020387",
"name": "17-oh-progesterone",
"pos": [
185,
203
]
} |
in case 1 ( 18 yr old female ) who had had secondary amenorrhea for 2 years , the plasma levels of cortisol , pregnenolone , 17-oh-pregnenolone , dhea , androstenedione , testosterone , estradiol and corticosterone were elevated . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
110,
122
]
} | {
"id": "C0376260",
"name": "17-oh-pregnenolone",
"pos": [
125,
143
]
} |
these results suggest that the peripheral vascular resistance might be increased in the third trimester of normal pregnancy compared with that in the first trimester because the intracellular na+ concentrations were elevated , and the na+-k+-atpase activities in the cell membrane were decreased along the course of preg... | NA | {
"id": "C0032981",
"name": "third trimester",
"pos": [
88,
103
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
316,
325
]
} |
these results suggest that the peripheral vascular resistance might be increased in the third trimester of normal pregnancy compared with that in the first trimester because the intracellular na+ concentrations were elevated , and the na+-k+-atpase activities in the cell membrane were decreased along the course of preg... | NA | {
"id": "C0032979",
"name": "first",
"pos": [
150,
155
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
316,
325
]
} |
maternal plasma igf-1/smc concentrations were not distinguishable from those of nonpregnant women ( 9.2 +/- 1.7 nmol/l ) in the 1st and 2nd trimester of gestation ; | NA | {
"id": "C0032980",
"name": "2nd trimester",
"pos": [
136,
149
]
} | {
"id": "C0032961",
"name": "gestation",
"pos": [
153,
162
]
} |
these results suggest that ( 1 ) plasma igf-1/smc might be produced in fetal sites and its regulating mechanism is different from that in maternal sites , and that ( 2 ) igfs might play an important role in human fetal growth and development by its affect via igf or insulin receptors on the human fetal liver . | NA | {
"id": "C0021665",
"name": "smc",
"pos": [
46,
49
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
260,
263
]
} |
in order to elucidate the physiological significance of plasma dopamine , blood pressure , pulse rate ( pr ) , plasma concentrations of free or conjugated dopamine ( free or conjugated pda ) , noradrenaline ( pna ) and adrenaline ( pad ) were measured in 9 healthy volunteers . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
193,
206
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
219,
229
]
} |
thymocytes could also be induced to divide at nonpermissive temperatures ( 17 degrees c ) when incubated in the presence of the following combinations of stimulants , a ) the phorbol ester 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) and the calcium ionophore a23187 , b ) tpa and cona , or c ) a23187 and cona . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
175,
188
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol-13-acetate",
"pos": [
189,
226
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.