text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
twin specific breech pnm decreased with increasing birthweight of first and second twin to a low optimum in the weight group 2.5-2.9 kg , and thereafter rose for both first and second twin with birthweight 3.0 kg and above . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
56,
62
]
} | {
"id": "C0005612",
"name": "birthweight",
"pos": [
194,
205
]
} |
pro-opiomelanocortin ( pomc ) is the common precursor of several pituitary hormones including alpha-melanotropic hormone , adrenocorticotropic hormone , beta-lipotropin and beta-endorphin . | NA | {
"id": "C0033195",
"name": "pro-opiomelanocortin",
"pos": [
0,
20
]
} | {
"id": "C0023832",
"name": "beta-lipotropin",
"pos": [
153,
168
]
} |
however , neither vp nor a phorbol ester ( 4 beta-phorbol 12-myristate 13-acetate , pma ) was able to stimulate y-1 cell steroidogenesis . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
27,
40
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
84,
87
]
} |
growth hormone-releasing hormone ( ghrh ) and the phorbol ester tetradecanoylphorbol acetate ( tpa ) each stimulated a rapid and extensive ( up to 15-fold ) increase in the secretion of growth hormone from cultured ovine anterior pituitary cells . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
50,
63
]
} | {
"id": "C0039654",
"name": "tetradecanoylphorbol acetate",
"pos": [
64,
92
]
} |
micromolar concentrations of adrenergic ligands such as isoproterenol , norepinephrine , and epinephrine induced marked morphological alterations culminating in the stellate configuration and depigmentation of iecs . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
72,
86
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
93,
104
]
} |
prolonged expression of differentiated phenotype by chondrocytes cultured at low density on a composite substrate of collagen and agarose that restricts cell spreading . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
52,
64
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
153,
157
]
} |
in this paper we describe a new technique which allows prolonged cultivation of attached chondrocytes at low density while inhibiting spreading : the cells are grown on a composite substrate of agarose and collagen . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
89,
101
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
150,
155
]
} |
as the course of administration progressed , the columns of chondrocytes in the thickened middle zone became more and more numerous , many degenerated cells were seen , and the staining intensity of the matrix of the cartilage with with safranin-o decreased slightly . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
60,
72
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
151,
156
]
} |
over the range of body weights examined , hl mice had more lipid , less protein , and less ash than fp or hs mice of the same sex and body weight . | NA | {
"id": "C0497406",
"name": "over",
"pos": [
0,
4
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
134,
145
]
} |
screening of a cdna library from neurula stage xenopus laevis for notochord-specific sequences led to the isolation of a cdna clone , xk endo b ( xenopus keratin endo b ) , which encodes a nonepidermal type i keratin . | NA | {
"id": "C0010803",
"name": "keratin",
"pos": [
154,
161
]
} | {
"id": "C1179970",
"name": "type i keratin",
"pos": [
202,
216
]
} |
an analysis of variance revealed that normals could be differentiated from ocular hypertension and glaucoma patients using the amplitude of the perg ( second and fourth harmonic ) . | NA | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
75,
94
]
} | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
99,
107
]
} |
such damage can result from systemic pathology such as adrenergic stress ( e.g. , central serous chorioretinopathy ) or vascular disease ( e.g. , hypertension ) . | NA | {
"id": "C0042373",
"name": "vascular disease",
"pos": [
120,
136
]
} | {
"id": "C0020538",
"name": "hypertension",
"pos": [
146,
158
]
} |
isolated intestinal cells accumulate certain monosaccharides via an na+-dependent , active transport system localized in the brush-border membrane , and release sugar molecules at the basolateral boundary via a facilitated diffusion , passive system . | NA | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
45,
60
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
161,
166
]
} |
to clarify the role of ca2+-atpase in the development of cardiac rigor mortis , we examined the changes of cardiac rigidity and cardiac sarcoplasmic reticulum ca2+-atpase activity up to 5 h after the decapitation of rats . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
23,
26
]
} | {
"id": "C0916181",
"name": "sarcoplasmic reticulum ca2",
"pos": [
136,
162
]
} |
with color doppler ultrasonography abnormal flow patterns incurred through atherosclerotic changes in the vessel wall , stenoses , anastomoses , aneurysms and pseudoaneurysms can be reliably detected . | NA | {
"id": "C0002940",
"name": "aneurysms",
"pos": [
145,
154
]
} | {
"id": "C1510412",
"name": "pseudoaneurysms",
"pos": [
159,
174
]
} |
antisera to alpha 1-antichymotrypsin , alpha 1-antitrypsin and lysozyme were reacted with 20 cases of glioblastoma multiforme , seven anaplastic astrocytomas , eight astrocytomas , six oligodendrogliomas , four ependymomas and the cerebral cortex from six normal autopsy brains . | NA | {
"id": "C0017636",
"name": "glioblastoma multiforme",
"pos": [
102,
125
]
} | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
166,
178
]
} |
antibody against human il-1 alpha partially neutralized the activity of the lower mw il-1 , though it exhibited little effect on the higher mw il-1 . | NA | {
"id": "C0600251",
"name": "il-1",
"pos": [
23,
27
]
} | {
"id": "C0021755",
"name": "il-1",
"pos": [
143,
147
]
} |
we conclude that pma can stimulate il-2 secretion independent of the translocation of pkc activity , and suggest that there is an alternative mechanism of action for phorbol esters in activated t cells . | NA | {
"id": "C0039654",
"name": "pma",
"pos": [
17,
20
]
} | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
166,
180
]
} |
the ability to generate reconstructed antibodies , chimeric antibodies , catalytic antibodies and the use of modelled antibodies for the design of drugs is discussed . | NA | {
"id": "C0162594",
"name": "catalytic antibodies",
"pos": [
73,
93
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
118,
128
]
} |
these results were not due to differences in antigenic expression of the tumour cells but reflect the problem of accessibility of antigenic sites in vivo . | NA | {
"id": "C0003335",
"name": "antigenic",
"pos": [
45,
54
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
130,
139
]
} |
to demonstrate the precise distribution and binding of in vivo injected monoclonal antibodies on histological tumour sections , we have biotinylated our primary antibody aua1 . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
72,
93
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
161,
169
]
} |
several antibodies gave good type-b reactions in addition to strong type-a reactivity ( mabs 126e7 , 115g2 , 115d8 , 140c1 , f36/22 , 139h2 ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
8,
18
]
} | {
"id": "C0003250",
"name": "mabs",
"pos": [
88,
92
]
} |
such a specific type of staining was exclusively induced by antibodies directed against epitopes of keratin 8 and 18 , whereas those mabs recognizing keratin 7 and 19 always gave negative results . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
60,
70
]
} | {
"id": "C0003250",
"name": "mabs",
"pos": [
133,
137
]
} |
in group d , there were 3 false negative scans with 11.4.1 antibody and 3 false negative scans with 4c4 f ( ab ' ) 2 mab . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
59,
67
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
117,
120
]
} |
the cellular dynamics of dermal regeneration were studied in nonsutured cutaneous wounds of female pigs and monkeys with electron microscopy and immunohistochemistry to demonstrate the origin and the development of fibroblasts forming granulation tissue . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
4,
12
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
215,
226
]
} |
by calculating the ratio of hb a/hb fac or hb f/hb a it is possible to detect newborns heterozygous for beta ( + ) - or beta ( 0 ) -thalassemia . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
28,
30
]
} | {
"id": "C0015936",
"name": "hb f",
"pos": [
43,
47
]
} |
fk482 was more active in vitro than cefixime ( cfix ) , cefaclor ( ccl ) or cephalexin ( cex ) against clinical isolates of gram-positive organisms such as methicillin-sensitive staphylococcus aureus , coagulase-negative staphylococci including staphylococcus epidermidis and strains of the streptococcus group . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
56,
64
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
76,
86
]
} |
against clinical isolates of many gram-negative species , including opportunistic pathogens , fk482 had good in vitro activity similar or slightly inferior to that of cfix but superior to that of ccl or cex . | NA | {
"id": "C0007537",
"name": "ccl",
"pos": [
196,
199
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
203,
206
]
} |
all tested strains of klebsiella pneumoniae resistant to ccl and cex were susceptible to fk482 , as were all the strains of escherichia coli , proteus mirabilis , haemophilus influenzae and branhamella catarrhalis resistant to amoxicillin ( ampc ) . | NA | {
"id": "C0007537",
"name": "ccl",
"pos": [
57,
60
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
65,
68
]
} |
fk482 , like cfix , was relatively stable to all type of beta-lactamases except bacteroides fragilis and its stability was superior to that of ccl or cex . | NA | {
"id": "C0007537",
"name": "ccl",
"pos": [
143,
146
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
150,
153
]
} |
fk482 showed higher affinity for the penicillin-binding proteins ( pbps ) ( 3 , 2 and 1 ) of s. aureus than did cfix , ccl and cex . | NA | {
"id": "C0007537",
"name": "ccl",
"pos": [
119,
122
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
127,
130
]
} |
the bactericidal activity of fk482 against s. aureus was almost as strong as that of ampc and superior to that of ccl or cex . | NA | {
"id": "C0007537",
"name": "ccl",
"pos": [
114,
117
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
121,
124
]
} |
against gram-negative bacteria such as e. coli , k. pneumoniae and p. mirabilis , fk482 was similar to cfix and superior to ccl and cex in bactericidal activity . | NA | {
"id": "C0007537",
"name": "ccl",
"pos": [
124,
127
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
132,
135
]
} |
in systemic infections in mice , oral fk482 was almost as effective as oral cefaclor ( ccl ) and more effective than oral cephalexin ( cex ) against staphylococcus aureus , escherichia coli , klebsiella pneumoniae and proteus mirabilis infections . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
76,
84
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
122,
132
]
} |
in local infections in rabbits , a species in which fk482 was better absorbed than in mice , fk482 was more effective than ccl , cex or amoxicillin ( ampc ) . | NA | {
"id": "C0007537",
"name": "ccl",
"pos": [
123,
126
]
} | {
"id": "C0007716",
"name": "cex",
"pos": [
129,
132
]
} |
the pharmacokinetic profile of fk482 was studied in mice , rats , rabbits and dogs after oral dosing and compared with that of cefixime , cefaclor and cephalexin . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
138,
146
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
151,
161
]
} |
fk482 was moderately well absorbed , with higher plasma levels than cefixime in rabbits and , like cefixime , gave higher plasma levels and a longer half-life than cefaclor or cephalexin in dogs . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
164,
172
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
176,
186
]
} |
a total of 7,690 records were analyzed for birth weight , weaning weight and preweaning daily gain with a model that included year of birth , sire within year of birth , age of dam and a covariate of day of birth for birth weight or age at weaning for the weaning traits . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
49,
55
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
217,
229
]
} |
the growth of wine-spoiling yeasts and lactic acid bacteria were not inhibited by water- or ethanol-soluble extracts of the filter material . | NA | {
"id": "C0043188",
"name": "wine",
"pos": [
14,
18
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
92,
99
]
} |
fourteen beta-lactam antibiotics were tested and four phenotypes were defined on the basis of enzymatic resistance and of susceptibility to the following beta-lactams : ticarcillin , piperacillin , cefotaxime , and ceftazidime . | NA | {
"id": "C0026458",
"name": "beta-lactam antibiotics",
"pos": [
9,
32
]
} | {
"id": "C0282215",
"name": "beta-lactams",
"pos": [
154,
166
]
} |
in most ( 71 % ) of the beta-lactamase producing strains , a penicillinase of the tem type was observed ; | NA | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
24,
38
]
} | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
61,
74
]
} |
unlike the beta-lactams , gentamicin and tobramycin bound avidly to both sources of alginate and , when the alginate gel to antibiotic ratio was high , the aminoglycosides exhibited diffusion coefficients which were approximately 20 % of the beta-lactam values . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
26,
36
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
156,
171
]
} |
gastric mucosal concentrations of erythromycin , amoxycillin , ampicillin and ciprofloxacin were determined in patients at upper gastrointestinal endoscopy 38-480 min after a 500 mg dose of erythromycin ethyl succinate , erythromycin stearate , amoxycillin , pivampicillin or ciprofloxacin . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
34,
46
]
} | {
"id": "C0014810",
"name": "erythromycin ethyl succinate",
"pos": [
190,
218
]
} |
gastric mucosal concentrations of erythromycin , amoxycillin , ampicillin and ciprofloxacin were determined in patients at upper gastrointestinal endoscopy 38-480 min after a 500 mg dose of erythromycin ethyl succinate , erythromycin stearate , amoxycillin , pivampicillin or ciprofloxacin . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
34,
46
]
} | {
"id": "C0059566",
"name": "erythromycin",
"pos": [
221,
233
]
} |
gastric mucosal concentrations of erythromycin , amoxycillin , ampicillin and ciprofloxacin were determined in patients at upper gastrointestinal endoscopy 38-480 min after a 500 mg dose of erythromycin ethyl succinate , erythromycin stearate , amoxycillin , pivampicillin or ciprofloxacin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
63,
73
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
245,
256
]
} |
gastric mucosal concentrations of erythromycin , amoxycillin , ampicillin and ciprofloxacin were determined in patients at upper gastrointestinal endoscopy 38-480 min after a 500 mg dose of erythromycin ethyl succinate , erythromycin stearate , amoxycillin , pivampicillin or ciprofloxacin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
63,
73
]
} | {
"id": "C0032032",
"name": "pivampicillin",
"pos": [
259,
272
]
} |
mixed infections can occur anywhere in the body and , on the basis of the location of the infection , involve predictable species of anaerobic bacteria . | NA | {
"id": "C0275524",
"name": "mixed infections",
"pos": [
0,
16
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
90,
99
]
} |
muscle glycogen storage was significantly increased above the basal rate ( p , 0.5 mumol.g wet wt-1.h-1 ) after ingestion of either glucose polymer supplement . | NA | {
"id": "C0017911",
"name": "glycogen",
"pos": [
7,
15
]
} | {
"id": "C0017696",
"name": "glucose polymer",
"pos": [
132,
147
]
} |
cell type specific cytoskeletal markers were demonstrated by antibodies to intermediate filament proteins ( keratin and epithelial membrane antigen ) . | NA | {
"id": "C0021769",
"name": "intermediate filament",
"pos": [
75,
96
]
} | {
"id": "C0010803",
"name": "keratin",
"pos": [
108,
115
]
} |
the factor produced by nt2/d1 ec cells exhibits a thermal stability curve that is nearly identical to those for bovine fgfb and fgfb from sk-hep-1 cells . | NA | {
"id": "C0016026",
"name": "fgfb",
"pos": [
119,
123
]
} | {
"id": "C0079349",
"name": "fgfb",
"pos": [
128,
132
]
} |
chloroquine phosphate ( cp ) has been formulated in a suppository base consisting of polyethylene glycol , peg 1000 and peg 6000 ( 7:3 ) with 0.5 % polysorbate 80 included as an absorption promoter . | NA | {
"id": "C0032483",
"name": "polyethylene glycol",
"pos": [
85,
104
]
} | {
"id": "C0030775",
"name": "peg 6000",
"pos": [
120,
128
]
} |
peak chloroquine blood levels in children ( mean body weight 10 kg , age 21 months ) were 0.67 +/- 0.08 micrograms/ml ( after 200 mg cp ) and 1.06 +/- 0.23 micrograms/ml ( after 300 mg cp ) following rectal administration of the suppositories . | NA | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
5,
16
]
} | {
"id": "C0055447",
"name": "cp",
"pos": [
185,
187
]
} |
( 3 ) assay of haem biosynthetic enzyme activities and ( 4 ) resolution of type isomers of porphyrins and porphyrinogens . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
91,
101
]
} | {
"id": "C0032711",
"name": "porphyrinogens",
"pos": [
106,
120
]
} |
unsaturated disaccharides produced with heparitinase and/or heparinase from heparan sulphate and oligosaccharides produced by hyaluronidase digestion of hyaluronic acid can be separated by hplc . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
12,
25
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
97,
113
]
} |
the quantitative determination of urinary indicator proteins such as albumin and alpha 1- and beta 2-microglobulin can be regarded as a reasonable complement to the pattern diagnosis , especially in the long-term course of renal diseases . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
52,
60
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
69,
76
]
} |
this review briefly describes the biochemistry of pterins , their involvement in pathological processes and the use of pterin measurement in diagnosis and monitoring of disease . | NA | {
"id": "C0030660",
"name": "pathological processes",
"pos": [
81,
103
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
169,
176
]
} |
hplc measurements afforded capacity factors , k , for these aromatic acids on a reversed stationary phase as a function of the mobile phase composition , which consisted of methanol ( or ethanol ) , water and acetic acid . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
173,
181
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
187,
194
]
} |
the specificity of endoscopic biopsy specimens in diagnosing congestive gastropathy in 20 patients with portal hypertension , 20 patients with liver disease without portal hypertension , and 20 patients with a normal stomach at endoscopy without liver disease was examined . | NA | {
"id": "C0020541",
"name": "portal hypertension",
"pos": [
104,
123
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
246,
259
]
} |
similar changes were also seen in 17 ( 85 % ) of patients with liver disease without portal hypertension and in 16 ( 84 % ) of patients with normal endoscopies without liver disease . | NA | {
"id": "C0020541",
"name": "portal hypertension",
"pos": [
85,
104
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
168,
181
]
} |
the organization of the spinocerebellar projection was analysed by the anterograde axonal wga-hrp ( horseradish peroxidase-wheat germ agglutinin conjugate ) tracing method in three different types of agranular cerebellar cortex either induced experimentally by x-irradiation or occurring spontaneously in weaver ( wv/wv ... | NA | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
90,
97
]
} | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
100,
122
]
} |
the projection fields of spinocerebellar tracts arising from the lowest lumbar and sacral-caudal segments were studied by the anterograde transport of wheat germ agglutinin conjugated to horseradish peroxidase ( wga-hrp ) in the cat . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
187,
209
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
212,
219
]
} |
the present investigation was carried out to clarify the topographical details of both the origin and terminal site of the thalamic projections and the commissural connections of the ventral lateral geniculate nucleus ( lgnv ) in the cat by using bidirectional transport of wheat germ agglutinin conjugated to horseradis... | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
310,
332
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
335,
342
]
} |
choline acetyltransferase ( chat ) immunocytochemistry and lectin-conjugated horseradish peroxidase ( wga-hrp ) histochemistry were combined at the electron microscopic level to examine the morphology of cholinergic terminals in the canine centrum medianum-parafascicular complex ( cm-pf ) and to localize cholinergic te... | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
77,
99
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
102,
109
]
} |
three features are analyzed : 1 ) the distribution and density of ache-containing fibers , 2 ) the presence of ache-positive cells , and 3 ) the distribution of butyrylcholinesterase ( buche ) -positive elements . | NA | {
"id": "C0001044",
"name": "ache",
"pos": [
66,
70
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
161,
182
]
} |
a vast amount of laboratory data have clearly demonstrated the potent antiproliferative and differentiation-inducing effects of vitamin a and the synthetic analogues ( retinoids ) . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
128,
137
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
168,
177
]
} |
elemental gold , administered parenterally and orally , is used to a moderate extent to treat rheumatoid arthritis , sjogren 's syndrome and nondisseminated lupus erythematosus . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
94,
114
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
117,
136
]
} |
the reversal potential shifted to about -50 mv when acetate or sulphate were injected as counter anions . | NA | {
"id": "C0038720",
"name": "sulphate",
"pos": [
63,
71
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
97,
103
]
} |
the clinical decision to consider surgery in children with epilepsy requires an understanding of the natural history of pediatric seizures , the constraints of the presurgical evaluation , and the relationship between surgical outcome and tissue pathology . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
59,
67
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
130,
138
]
} |
this was related to pancreatic inflammation in chronic pancreatitis and to several factors , among which jaundice and pancreatic damage , in pancreatic cancer . | NA | {
"id": "C0030305",
"name": "pancreatic inflammation",
"pos": [
20,
43
]
} | {
"id": "C0149521",
"name": "chronic pancreatitis",
"pos": [
47,
67
]
} |
axa peak level and half life in plasma of the anti xa activity were about double than the corresponding values of anti iia activity and the effect on ptt , when compared with the same reference material ( heparin , third internat . standard ) . | NA | {
"id": "C0019139",
"name": "anti xa",
"pos": [
46,
53
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
205,
212
]
} |
then , the duration of labor , the blood loss during delivery , the birth weight , the placental weight and the obstetrical abnormalities ( prolonged labor , arrested labor , blood loss of more than 500 ml , fetal distress and toxemia of pregnancy ) were investigated in these groups . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
68,
80
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
97,
103
]
} |
the blood loss , the neonatal birth weight and the placental weight in the obese groups were much greater than those in the ordinary or the slender group ( p less than 0.005 ) . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
30,
42
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
61,
67
]
} |
at the end of buserelin treatment baseline levels of plasma lhrh , lhrh pulse amplitude and frequency were not lowered . | NA | {
"id": "C0006456",
"name": "buserelin",
"pos": [
14,
23
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
67,
71
]
} |
adrenaline and noradrenaline levels rose markedly , and the mean corpuscular haemoglobin concentration ( mchc in mmol hb l-1 red blood cells ) decreased , indicating swelling of the erythrocytes . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
15,
28
]
} |
although of similar gtp-sensitivity as g-protein-activated events , the apparent dependence on gtp hydrolysis and blockade by gtp gamma s suggest a mechanism distinct from those mediated by known g-proteins . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
20,
23
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
126,
137
]
} |
cytosolic free calcium concentration and cumulative gh release were measured simultaneously in anterior pituitary cells from adult male rats . | NA | {
"id": "C0037663",
"name": "gh",
"pos": [
52,
54
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
95,
113
]
} |
pretreatment of the cells with natural huifn-beta inhibited the appearance of immediate-early antigen ( iea ) or pre-early nuclear antigen ( pena ) as well as the production of infectious cmv . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
94,
101
]
} | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
123,
138
]
} |
in the present series of experiments we have studied the effects of the dihydropyridine calcium channel antagonist nifedipine on ethanol-induced changes in behavior and dopamine ( da ) release and metabolism . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium",
"pos": [
72,
95
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
115,
125
]
} |
in the late stages of hiv infection , associated with increasing severity of immunodeficiency , free virus could readily be isolated from the csf . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
22,
35
]
} | {
"id": "C0021051",
"name": "immunodeficiency",
"pos": [
77,
93
]
} |
gross or microscopic glial hamartomas were found in the anterior olfactory lobe and olfactory germinal layer of three babies , two of them newborns , with tuberous sclerosis . | NA | {
"id": "C0018552",
"name": "hamartomas",
"pos": [
27,
37
]
} | {
"id": "C0041341",
"name": "tuberous sclerosis",
"pos": [
155,
173
]
} |
investigation of the link between these observations and the proposed myelin proteolipid protein defect in the md rat may reveal more about the role of myelin proteins in the cns , and the specific cellular defect ( s ) in this mutant . | NA | {
"id": "C0060617",
"name": "myelin proteolipid protein",
"pos": [
70,
96
]
} | {
"id": "C0026972",
"name": "myelin proteins",
"pos": [
152,
167
]
} |
the antibody was obtained during a search for cell type-specific monoclonal antibodies in the rat retina . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
4,
12
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
65,
86
]
} |
compared to cholesterol-fed cellulose controls , all oat fibers altered the response to cholesterol feeding as indicated by 25-45 % lower total lipoprotein cholesterol , 40-60 % lower vldl + ldl cholesterol , and 25-40 % higher hdl cholesterol contents , p less than 0.01 . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
12,
23
]
} | {
"id": "C0023824",
"name": "ldl cholesterol",
"pos": [
191,
206
]
} |
the initial high amounts of mono-l-alanyl-l-cystine and mono-glycyl-l-cystine as well as the prompt increase of the constituent free amino acids alanine , glycine and cystine strongly suggest that the peptide disappearance is mainly due to a very fast two-step hydrolysis in the extracellular compartment , presumably ca... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
133,
144
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
145,
152
]
} |
the initial high amounts of mono-l-alanyl-l-cystine and mono-glycyl-l-cystine as well as the prompt increase of the constituent free amino acids alanine , glycine and cystine strongly suggest that the peptide disappearance is mainly due to a very fast two-step hydrolysis in the extracellular compartment , presumably ca... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
133,
144
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
155,
162
]
} |
the fate of cereal fructans and inulin in the gastrointestinal tract was investigated by using a rat model . | NA | {
"id": "C0016743",
"name": "fructans",
"pos": [
19,
27
]
} | {
"id": "C0021936",
"name": "inulin",
"pos": [
32,
38
]
} |
male wistar rats received diets containing 5.0 % of a preparation of cereal fructans or 4.7 or 9.4 % inulin . | NA | {
"id": "C0016743",
"name": "fructans",
"pos": [
76,
84
]
} | {
"id": "C0021936",
"name": "inulin",
"pos": [
101,
107
]
} |
only minute amounts of fructans could be detected , hence , cereal fructans as well as inulin reaching the hindgut appeared to be almost completely fermentable . | NA | {
"id": "C0016743",
"name": "fructans",
"pos": [
23,
31
]
} | {
"id": "C0021936",
"name": "inulin",
"pos": [
87,
93
]
} |
it appears that hypothyroidism , induced either by thyroidectomy or by feeding thiouracil , slows the rate of depletion of hepatic b-12 which in turn facilitates the metabolism of methylmalonic acid and decreases its excretion in the urine . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
166,
176
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
217,
226
]
} |
evidence suggests that subclinical intrauterine infections which can be indicated by elevated maternal crp-values may cause preterm labor and that ureaplasma urealyticum might play a role in the pathogenesis of preterm delivery . | NA | {
"id": "C0022876",
"name": "preterm labor",
"pos": [
124,
137
]
} | {
"id": "C0151526",
"name": "preterm",
"pos": [
211,
218
]
} |
with inward 50 mm anion gradients , the initial rates of br and i entry ( jbr and ji , respectively ) were not significantly different from jc1.jc1 was a saturable function of c1 concentration with apparent kd of 24 mm and apparent vmax of 0.54 nmol.sec-1.mg protein-1 . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
18,
23
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
264,
265
]
} |
two distinct nucleoprotein complexes are formed , a complex with high electrophoretic mobility carrying probably only one protein molecule , and a complex with reduced electrophoretic mobility carrying probably two protein molecules per dna fragment . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
13,
26
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
215,
222
]
} |
specific codon usage pattern and its implications on the secondary structure of silk fibroin mrna . | NA | {
"id": "C0074529",
"name": "silk",
"pos": [
80,
84
]
} | {
"id": "C0016042",
"name": "fibroin",
"pos": [
85,
92
]
} |
the codon usage for the major amino acids , glycine , alanine and serine is distinctly different in these two regions , indicating that it is determined by the fibroin mrna or gene structure but not by the trna population . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
30,
35
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
44,
51
]
} |
the codon usage for the major amino acids , glycine , alanine and serine is distinctly different in these two regions , indicating that it is determined by the fibroin mrna or gene structure but not by the trna population . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
30,
35
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
54,
61
]
} |
to determine whether catecholamines produce alterations in myocardial myosin-actin cycling kinetics , we investigated the effects of isoproterenol upon mechanical characteristics of constantly activated heart muscle thought to reflect crossbridge behavior . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
21,
35
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
133,
146
]
} |
in the rat heart diabetes mellitus leads to a change in myosin heavy chain ( mhc ) mrnas and corresponding alterations in myosin isoenzymes as well as a decrease in total cardiac protein synthesis . | NA | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
56,
74
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
122,
128
]
} |
the remaining protein showed a shift in isoelectric point without a change in molecular weight possibly representing isoforms of a single polypeptide . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
14,
21
]
} | {
"id": "C0597298",
"name": "isoforms",
"pos": [
117,
125
]
} |
the relationship between the percentage of rod-shaped rat heart myocytes and atp , creatine phosphate , creatine and inorganic phosphate content was determined . | NA | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
83,
101
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
104,
112
]
} |
the rickettsial diseases of man in japan include tsutsugamushi disease ( scrub typhus ) , murine typhus , which occurs sporadically , and one of spotted fever group diseases , recognized as a new entity since 1984 . | NA | {
"id": "C0035585",
"name": "rickettsial diseases",
"pos": [
4,
24
]
} | {
"id": "C0041472",
"name": "murine typhus",
"pos": [
90,
103
]
} |
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