text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
its effect was enhanced by gaba , muscimol , aminooxyacetic acid and diaminobutyric acid , but not by baclofen , and blocked by bicuculline methiodide . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
27,
31
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
102,
110
]
} |
the binding properties of a 1,4-dihydropyridine ( dhp ) calcium entry blocker , [ 3h ] nimodipine , to a microsomal fraction from rat vas deferens was characterized . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
32,
47
]
} | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
87,
97
]
} |
5'-guanylylimidodiphosphate caused a rightward shift of the displacement curve for bay k 8644 but not for nimodipine , suggesting the involvement of guanine nucleotide binding protein in the signal transduction between the dhp binding site and the ca2+ channel . | NA | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
106,
116
]
} | {
"id": "C0012315",
"name": "dhp",
"pos": [
223,
226
]
} |
pea derivatives decreased norepinephrine in the brain and tended to increase normetanephrine at 15 min after the administration of pea derivatives . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
26,
40
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
77,
92
]
} |
antibody titers in serum of diffuse panbronchiolitis patients administered a multicomponent pseudomonas aeruginosa vaccine consisting of toxoids of protease , elastase and exotoxin a and a common protective antigen ( oep ) . | NA | {
"id": "C0042210",
"name": "vaccine",
"pos": [
115,
122
]
} | {
"id": "C0040555",
"name": "toxoids",
"pos": [
137,
144
]
} |
a multicomponent pseudomonas aeruginosa vaccine consisting of toxoids of protease , elastase , exotoxin a and a common protective antigen ( oep ) : basic concept of vaccination and prospect of clinical application . | NA | {
"id": "C0042210",
"name": "vaccine",
"pos": [
40,
47
]
} | {
"id": "C0040555",
"name": "toxoids",
"pos": [
62,
69
]
} |
[ desmoid fibromas in patients with diffuse polyposis of the large intestine ( a review of the literature ) ] . | NA | {
"id": "C0079218",
"name": "desmoid",
"pos": [
2,
9
]
} | {
"id": "C0016045",
"name": "patients",
"pos": [
22,
30
]
} |
regarding different histologic types chemotherapy produced response rates of 56 % in pnets ( primitive neuroectodermale tumors ) , 49 % in medulloblastomas , 32 % in ependymomas , 31 % in brain stem gliomas , and 30 % in astrocytomas/glioblastomas . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
221,
233
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
234,
247
]
} |
in high risk patients ( extremity tumors greater than 100 ml tumor volume , central tumors ) , cyclophosphamide in conventional dose ( 1200 mg/m2/course ) was replaced by high doses of ifosfamide ( 6 g/m2/course ) with mesna uroprotection ( vaia ) . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
95,
111
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
185,
195
]
} |
to our knowledge , actinomycosis associated with hiv-infection ( aids-related complex ) has been reported only once previously . | NA | {
"id": "C0019693",
"name": "hiv-infection",
"pos": [
49,
62
]
} | {
"id": "C0001857",
"name": "aids-related complex",
"pos": [
65,
85
]
} |
consequently , it is possible to predict successfully the location of antigenic epitopes in proteins using the averaged mutation rate of protein sequence pieces . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
70,
79
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
80,
88
]
} |
to test this hypothesis in vivo , we assessed induction of il 6 following il 1 alpha administration to mice and tested il 6 for radioprotection and induction of early ( csf ) and late ( fibrinogen and saa ) acute phase reactants . | NA | {
"id": "C0016006",
"name": "fibrinogen",
"pos": [
186,
196
]
} | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
207,
228
]
} |
to test this hypothesis in vivo , we assessed induction of il 6 following il 1 alpha administration to mice and tested il 6 for radioprotection and induction of early ( csf ) and late ( fibrinogen and saa ) acute phase reactants . | NA | {
"id": "C0002723",
"name": "saa",
"pos": [
201,
204
]
} | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
207,
228
]
} |
we found that the cell-associated form of a factor specific for l-glutamic acid60-l-alanine30-l-tyrosine10 ( gat-tsf1 ) is a 66 kda protein which exhibits a slightly acidic isoelectric point , but no carbohydrate as determined by enzymatic analysis and lectin-affinity chromatography . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
132,
139
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
253,
259
]
} |
these results suggest that membrane il 1 , primarily il 1 alpha , was cytotoxic for the a375 cells . | NA | {
"id": "C0021755",
"name": "il 1",
"pos": [
36,
40
]
} | {
"id": "C0600251",
"name": "il 1 alpha",
"pos": [
53,
63
]
} |
cellular effects of the pulsed tunable dye laser at 577 nanometers on human endothelial cells , fibroblasts , and erythrocytes : an in vitro study . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
0,
8
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
96,
107
]
} |
with normal estrous cyclicity established by vaginal smears , were injected intraperitoneally with 0.45 mg/kg ( low dose ) or 0.68 mg/kg ( high dose ) of t-2 toxin , a trichothecene with potent protein inhibitory abilities . | NA | {
"id": "C0039185",
"name": "t-2 toxin",
"pos": [
154,
163
]
} | {
"id": "C0040952",
"name": "trichothecene",
"pos": [
168,
181
]
} |
ps/pc liposomes interact predominantely with the plasma membrane of tb cells and release cat1 continuously , whereas the majority of ps/dspc/dppc liposomes are taken into the cells intact via endocytosis . | NA | {
"id": "C1959616",
"name": "ps/pc",
"pos": [
0,
5
]
} | {
"id": "C0000039",
"name": "ps/dspc/dppc",
"pos": [
133,
145
]
} |
the promoter is followed by four open reading frames , designated ugpb , a , e and c , which encode a periplasmic binding protein , two hydrophobic membrane proteins and a protein that is likely to couple energy to the transport system , respectively . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
148,
165
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
172,
179
]
} |
sequencing and characterization of two cloned cdnas revealed the existence of two distinct , but closely related , isoforms of plastin -- l-plastin , which is expressed in leukocytes and transformed fibroblasts , and t-plastin , which is expressed in normal cells of solid tissues and transformed fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
258,
263
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
297,
308
]
} |
the leukocyte isoform l-plastin is expressed in a diverse variety of human tumor cell lines , suggesting that it may be involved in the neoplastic process of some solid human tumors . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
75,
80
]
} | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
136,
154
]
} |
while high-level gamma-globin expression was common , the lines differed in their expression of embryonic ( epsilon , zeta ) and adult ( delta , beta ) globin mrnas . | NA | {
"id": "C0017033",
"name": "gamma-globin",
"pos": [
17,
29
]
} | {
"id": "C0005221",
"name": "beta",
"pos": [
145,
149
]
} |
since this phenotype is likely associated with the preferential affinity of the mutant protein for gdp , analogous mutations might also yield inhibitors of other proteins whose activities are regulated by guanine nucleotide binding . | NA | {
"id": "C1564139",
"name": "mutant protein",
"pos": [
80,
94
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
162,
170
]
} |
since this phenotype is likely associated with the preferential affinity of the mutant protein for gdp , analogous mutations might also yield inhibitors of other proteins whose activities are regulated by guanine nucleotide binding . | NA | {
"id": "C0018340",
"name": "gdp",
"pos": [
99,
102
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
205,
223
]
} |
these cells also synthesize relatively large amounts of a 70,000-molecular-weight protein ( p70 ) that appears to be a cell-specific isoform of hsp70 , the major heat-inducible protein ( r.l . | NA | {
"id": "C0597298",
"name": "isoform",
"pos": [
133,
140
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
177,
184
]
} |
together , these results show that hsv induces a dna replicative activity which amplifies foreign dna . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
47,
52
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
98,
101
]
} |
the levels and transcription rates of four mrnas ( albumin , alpha-1-antitrypsin , apolipoprotein a1 , and major urinary protein [ mup ] ) fell sharply . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
51,
58
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
121,
128
]
} |
two regions of the fgf-5 sequence , containing 122 of its 267 amino acid residues , were 40 to 50 % homologous to the sequences of acidic and basic fgfs as well as to the sequences of the fgf-related oncoproteins int-2 and hst/ks3 . | NA | {
"id": "C0117720",
"name": "fgf-5",
"pos": [
19,
24
]
} | {
"id": "C0016026",
"name": "fgfs",
"pos": [
148,
152
]
} |
two regions of the fgf-5 sequence , containing 122 of its 267 amino acid residues , were 40 to 50 % homologous to the sequences of acidic and basic fgfs as well as to the sequences of the fgf-related oncoproteins int-2 and hst/ks3 . | NA | {
"id": "C0016026",
"name": "fgfs",
"pos": [
148,
152
]
} | {
"id": "C0380603",
"name": "fgf",
"pos": [
188,
191
]
} |
several experiments strongly suggested that fgf-5 is a growth factor with properties common to those of acidic and basic fgfs . | NA | {
"id": "C0117720",
"name": "fgf-5",
"pos": [
44,
49
]
} | {
"id": "C0016026",
"name": "fgfs",
"pos": [
121,
125
]
} |
bsf-2 acts on a variety of cells other than b cells , and moreover , expression of bsf-2 mrna is detected in interleukin-1 beta-stimulated glioblastoma and astrocytoma cell lines . | NA | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
139,
151
]
} | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
156,
167
]
} |
in order to obtain steroid-independent probes for human progesterone receptor ( pr ) , the a [ 88-93 kilodalton ( kda ) ] and b ( 109-119 kda ) forms of pr from t47d human breast cancer cells were partially purified and used to generate a series of 14 monoclonal antibodies . | NA | {
"id": "C0034840",
"name": "steroid",
"pos": [
19,
26
]
} | {
"id": "C0034833",
"name": "pr",
"pos": [
153,
155
]
} |
the second rna , migrating at about 3 kilobases , is a novel tgf beta mrna which we have named tgf beta 3 . | NA | {
"id": "C0040690",
"name": "tgf beta",
"pos": [
61,
69
]
} | {
"id": "C0812319",
"name": "tgf beta 3",
"pos": [
95,
105
]
} |
in the presence of calcium , sap binds to certain complex polysaccharides , including agarose and zymosan . | NA | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
58,
73
]
} | {
"id": "C0036681",
"name": "agarose",
"pos": [
86,
93
]
} |
these findings indicate that mannose-terminated oligosaccharides of polysaccharides and glycoproteins represent a new class of ligands for sap and suggest that sap may function as a mannose-binding protein . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
48,
64
]
} | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
68,
83
]
} |
furthermore , human rye i specific igg could inhibit the binding of 125i-labelled 539a-6 mab to its specific anti-id antibody to a significant degree . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
89,
92
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
117,
125
]
} |
based on an earlier demonstration ( carayanniotis and barber , 1987 ) that protein antigens could be made immunogenic in the absence of adjuvant , if coupled to mabs specific for the recipient 's class ii major histocompatibility complex ( mhc ) antigens , the hsv synthetic peptides were photocoupled to avidin and mixe... | NA | {
"id": "C0003250",
"name": "mabs",
"pos": [
161,
165
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
365,
375
]
} |
in general , the antibodies were strongly cross-reactive with the opiate agonists , codeine , ethylmorphine , dihydromorphine and dihydrocodeine , while their cross-reactivities with norcodeine and the opiate antagonists , naloxone and naltrexone , were weak . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
223,
231
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
236,
246
]
} |
the cross-reactivities with dihydromorphinone , dihydrocodeinone , naloxone , naltrexone , dextromethorphan and homatropine varied from clone to clone . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
67,
75
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
78,
88
]
} |
the third peptide is a 2.5 kd c-terminal fragment of the cryptic peptide , representing a processed form of gap . | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
10,
17
]
} | {
"id": "C0030935",
"name": "fragment",
"pos": [
41,
49
]
} |
although sebaceous carcinoma of the eyelids does not appear to presage the muir-torre syndrome , any benign sebaceous or transitional squamo-sebaceous neoplasm should be considered a possible manifestation of this syndrome . | NA | {
"id": "C1321489",
"name": "muir-torre syndrome",
"pos": [
75,
94
]
} | {
"id": "C0036503",
"name": "sebaceous",
"pos": [
141,
150
]
} |
a long glaucoma valve implant attached to an external scleral explant was used during filtration surgery in 72 eyes : 39 eyes with neovascular glaucoma and 33 eyes with other types of secondary glaucomas or with primary glaucoma in which prior filtration surgery had failed . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
7,
15
]
} | {
"id": "C0017609",
"name": "neovascular glaucoma",
"pos": [
131,
151
]
} |
the percent area of fluorescein defect in the optic disc increased with severity of nfl defect in glaucoma and ocular hypertension . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
98,
106
]
} | {
"id": "C0028840",
"name": "ocular",
"pos": [
111,
117
]
} |
a 61-year-old woman , whose rheumatoid arthritis had been quiescent for 9 years , developed a crop fo 16 painless bilateral episcleral rheumatoid nodules without any flareup of her joint disease . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
28,
48
]
} | {
"id": "C0035450",
"name": "rheumatoid nodules",
"pos": [
135,
153
]
} |
the rheumatologic designation for the development of groups of subcutaneous nodules in inactive rheumatoid arthritis is rheumatoid nodulosis . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
96,
116
]
} | {
"id": "C0035450",
"name": "rheumatoid",
"pos": [
120,
130
]
} |
14c radioactivity in blood from galactose-fed pups was reduced as counts in blood galactose were lower than counts in blood glucose in glucose-fed pups . | NA | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
115,
131
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
135,
142
]
} |
nonetheless within 15 min , [ 14c ] from galactose appeared in blood glucose suggesting rapid conversion of galactose to glucose . | NA | {
"id": "C0005802",
"name": "in",
"pos": [
16,
18
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
121,
128
]
} |
the relatively delayed entry of glucose label into hepatic glycogen and the delay of net glycogen synthesis after oral glucose suggest that glucose entry is not direct and may require further metabolism before incorporation into glycogen . | NA | {
"id": "C0023902",
"name": "hepatic glycogen",
"pos": [
51,
67
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
229,
237
]
} |
atrial natriuretic factor ( anf ) is a class of diuretic and natriuretic peptides secreted by mammalian cardiac atria . | NA | {
"id": "C0027481",
"name": "atrial natriuretic factor",
"pos": [
0,
25
]
} | {
"id": "C1144709",
"name": "natriuretic peptides",
"pos": [
61,
81
]
} |
the evolution of the histopathological findings in the premature baboon model of hyaline membrane disease/bronchopulmonary dysplasia was investigated in this study and compared to that in oxygen-treated adult baboons with adult respiratory distress syndrome . | NA | {
"id": "C0020192",
"name": "hyaline membrane disease",
"pos": [
81,
105
]
} | {
"id": "C0035220",
"name": "respiratory distress syndrome",
"pos": [
228,
257
]
} |
advantages of continuous infusion are the long-term exposure of tumour cells to the drug and the fact that most toxic effects are reduced for doxorubicin , epirubicin and mitoxantrone due to elimination of the high peak plasma levels . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
142,
153
]
} | {
"id": "C0014582",
"name": "epirubicin",
"pos": [
156,
166
]
} |
the ( organo ) metal ions used were ( organic derivatives of ) transition elements and elements with a filled d-subshell . | NA | {
"id": "C0682906",
"name": "transition elements",
"pos": [
63,
82
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
87,
95
]
} |
the content of gentamicin in pharmaceuticals is measured by the high pressure liquid chromatographic technique described in the monographs for gentamicin sulphate and gentamicin injection in the british pharmacopoeia 1980 for the determination of the composition of gentamicin . | NA | {
"id": "C0546866",
"name": "gentamicin",
"pos": [
15,
25
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
266,
276
]
} |
binding of [ 125i ] tyr a14 human insulin ( [ 125i ] insulin ) was measured at 4 degrees c in glomeruli and pieces of tubule microdissected from collagenase-treated rat kidneys . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
28,
41
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
53,
60
]
} |
in some cases this suggestion is substantiated by the observation that the protected dna sequences show homology to the binding sites for ftz regulating dna-binding proteins such as the pair-rule gene product even-skipped . | NA | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
153,
173
]
} | {
"id": "C0033684",
"name": "gene product",
"pos": [
196,
208
]
} |
arrhythmias were congenital complete heart block in 19 , postoperative heart block in 15 , acquired heart block in 3 , sick sinus syndrome in 3 , and bradycardia-induced ventricular fibrillation in 1 . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
0,
11
]
} | {
"id": "C0018794",
"name": "heart block",
"pos": [
100,
111
]
} |
arrhythmias were congenital complete heart block in 19 , postoperative heart block in 15 , acquired heart block in 3 , sick sinus syndrome in 3 , and bradycardia-induced ventricular fibrillation in 1 . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
0,
11
]
} | {
"id": "C0042510",
"name": "ventricular",
"pos": [
170,
181
]
} |
nine patients presented atrial flutter , atrial fibrillation or atrial tachycardia , nine had supraventricular tachycardia ( one av nodal reentrant tachycardia , one reciprocating tachycardia due to concealed accessory pathway and seven wpw syndrome ) . | NA | {
"id": "C0039232",
"name": "av nodal reentrant tachycardia",
"pos": [
129,
159
]
} | {
"id": "C0242514",
"name": "reciprocating tachycardia",
"pos": [
166,
191
]
} |
gaba and glycine receptors induced by mrna from the cerebral cortex of all ages are associated with chloride channels . | NA | {
"id": "C0061605",
"name": "glycine receptors",
"pos": [
9,
26
]
} | {
"id": "C0055363",
"name": "chloride channels",
"pos": [
100,
117
]
} |
antinociceptive properties of [ d-ala2 , nmphe4 , gly-ol ] -enkephalin ( dago ) in tests of acute and tonic pain in mice . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
60,
70
]
} | {
"id": "C0525773",
"name": "dago",
"pos": [
73,
77
]
} |
to study the role played by opiate mechanisms in the tolerance to the anorectic effects of amphetamines , the influence of chronic treatment with d,1-amphetamine ( amph ) on the effects of the selective kappa opiate agonist u50488h ( u50 ) , of morphine ( morph ) and of diazepam ( dzp ) on food and water intake was eva... | NA | {
"id": "C0002667",
"name": "amphetamines",
"pos": [
91,
103
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
150,
161
]
} |
in view of the analgesic effects produced by cathinone ( cath ) , an amphetamine-like agent , and of the interaction of amphetamines with stressful environmental stimuli , the present study evaluated in rats the influence of cath on the nonopioid analgesia induced by a brief electric footshock ( fsa ; 3 min of continuo... | NA | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
69,
80
]
} | {
"id": "C0002667",
"name": "amphetamines",
"pos": [
120,
132
]
} |
sternocostoclavicular hyperostosis is a rare disease characterized by soft-tissue ossifications and hyperostosis of the clavicles , anterior segments of the upper ribs and sternum . | NA | {
"id": "C0020499",
"name": "sternocostoclavicular hyperostosis",
"pos": [
0,
34
]
} | {
"id": "C0020492",
"name": "hyperostosis",
"pos": [
100,
112
]
} |
[ sensitivity of bacteria to netilmicin in comparison with their sensitivity to gentamicin and other aminoglycosides ] . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
80,
90
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
101,
116
]
} |
pathological changes in the ischemic process are induced in a certain portion of the model to make it possible to evaluate the relationship between the type and degree of changes and abnormal ventricular wall motion ( i.e. , hypokinesis , akinesis , and dyskinesis ) . | NA | {
"id": "C0086439",
"name": "hypokinesis",
"pos": [
225,
236
]
} | {
"id": "C0013384",
"name": "dyskinesis",
"pos": [
254,
264
]
} |
we determined the total and free t3 , t4 , tsh , tbg , plasma cortisol transcortin , delta-4-androstenedione , fsh , lh , prolactin , total and free testosterone , estradiol , progesterone , sex hormone-binding globulin ( shbg ) , dehydroepiandrosterone ( dhea ) , dehydroepiandrosterone sulphate ( dheas ) and 17 hydrox... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
176,
188
]
} | {
"id": "C0020387",
"name": "17",
"pos": [
336,
338
]
} |
in order to assess the dopaminergic tonus , urinary determinations of hva and dopac and also of noradrenaline ( na ) , adrenaline ( a ) , and methoxyhydroxyphenylglycol ( mhpg ) were performed in 86 obese children , 11 growth hormone ( gh ) -deficient short children and also in 40 control children . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
96,
109
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
119,
129
]
} |
monoclonal antibodies to cd11a , b , or c block adhesion of certain types of leucocytes only , while several antibodies to cd18 inhibit adhesion in all of them . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
109,
119
]
} |
the specificity of the aca was studied in competitive inhibition experiments with three putative antigens : cardiolipin , lipopolysaccharide ( lps ) isolated from salmonella minnesota , strain re 595 , and synthetic escherichia coli lipid a . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
122,
140
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
233,
240
]
} |
alpha interferon ( ifn-alpha ) also contributed to cytostasis of the k562 cells , since antibodies against ifn-alpha partially inhibited the cytostatic activity in the supernatants , and further inhibition , although not complete , was obtained in the presence of both ifn-alpha antibodies and rtnf alpha antiserum . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
88,
98
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
305,
314
]
} |
auranofin in rheumatoid arthritis : use in patients with side-effects or lack of effect to gold sodium thiomalate or gold thioglucose and/or d-penicillamine . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
0,
9
]
} | {
"id": "C0018033",
"name": "gold thioglucose",
"pos": [
117,
133
]
} |
the measurements covered particle sizes of 0.01-7.5 microns and the following gases : carbon monoxide , ammonia , formaldehyde , nitric oxide , nitrogen dioxide , hydrocarbons , and hydrogen cyanide . | NA | {
"id": "C0017110",
"name": "gases",
"pos": [
78,
83
]
} | {
"id": "C0002607",
"name": "ammonia",
"pos": [
104,
111
]
} |
specifically , the interaction of inorganic mercury and polydimethylsiloxanes , and other silicones , to give methylmercury is important in this content . | NA | {
"id": "C0012436",
"name": "polydimethylsiloxanes",
"pos": [
56,
77
]
} | {
"id": "C0037114",
"name": "silicones",
"pos": [
90,
99
]
} |
to this end a series of laboratory experiments , in which inorganic mercury , short and long chain silicones , cyclic siloxanes , oxidized silicone gums , and industrial formulations containing silicones , were conducted . | NA | {
"id": "C0037121",
"name": "siloxanes",
"pos": [
118,
127
]
} | {
"id": "C0037114",
"name": "silicones",
"pos": [
194,
203
]
} |
localization of bhsp-specific binding was also abolished in whole-mounts coincubated with 1 nm substance p , but not with 1 nm neurokinin b , suggesting that binding was probably to an nk-1 tachykinin receptor . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
95,
106
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
190,
200
]
} |
localization of bhsp-specific binding was also abolished in whole-mounts coincubated with 1 nm substance p , but not with 1 nm neurokinin b , suggesting that binding was probably to an nk-1 tachykinin receptor . | NA | {
"id": "C0027847",
"name": "neurokinin b",
"pos": [
127,
139
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
190,
200
]
} |
the inhibitory neurotransmitter gamma-aminobutyric acid ( gaba ) hyperpolarizes spinal neurons by activating bicuculline sensitive gabaa receptors coupled to chloride permeable ionic channels in the cell membrane . | NA | {
"id": "C0034807",
"name": "gabaa receptors",
"pos": [
131,
146
]
} | {
"id": "C0055363",
"name": "chloride",
"pos": [
158,
166
]
} |
[ use of nuclear magnetic resonance in differential diagnosis of diseases of the adrenal glands with the syndrome of total and partial hypercorticism ] . | NA | {
"id": "C0001621",
"name": "of diseases",
"pos": [
62,
73
]
} | {
"id": "C0001622",
"name": "hypercorticism",
"pos": [
135,
149
]
} |
to elucidate the question of whether products of mast cells affect the proliferative behaviour of structural cells in the lung and thereby contribute to fibrogenesis , the effect of histamine , a prominent mast cell derived mediator , on the in vitro proliferation of primary cultures of normal adult human lung fibrobla... | NA | {
"id": "C0007634",
"name": "the",
"pos": [
13,
16
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
312,
323
]
} |
this effect occurred when cells were exposed to histamine at restricted times during cell growth and was shown to depend in part on the stage of the cell cycle reached by the fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
26,
31
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
175,
186
]
} |
a significant correlation was found between both gastric emptying half-time of radionuclide ( t1/2 ) and % isotope remained in the region of the stomach and paracetamol absorption kinetic parameters . | NA | {
"id": "C0034595",
"name": "radionuclide",
"pos": [
79,
91
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
107,
114
]
} |
plasma cck level increased to 3.65 +/- 0.79 and 19.9 +/- 4.47 pm ( mean +/- s.e . ) by a 2-hr infusion of 100 and 300 pmole/kg/hr of cck-octapeptide ( cck-8 ) , respectively . | NA | {
"id": "C0008328",
"name": "cck",
"pos": [
7,
10
]
} | {
"id": "C0037167",
"name": "cck-octapeptide",
"pos": [
133,
148
]
} |
the effect of pretreatment of mice with heavy metals : zn , cu , bi , co , cd or hg , against lethal and cardiac toxicity of adriamycin ( adr ) was investigated . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
40,
52
]
} | {
"id": "C0025424",
"name": "hg",
"pos": [
81,
83
]
} |
numerous cells of the cochlear duct including mesothelial and epithelial cells of reissner 's membrane , mesothelial cells lining the scala tympani , cells of the stria vascularis , numerous supportive cells of the organ of corti , cochlear hair cells , endothelial cells , perithelial cells , fibroblasts , macrophages ... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
294,
305
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
455,
460
]
} |
density gradient ultracentrifugation of chick plasma separated lipoproteins into three main fractions : portomicrons plus very low density lipoproteins ( pm + vldl ) , low density lipoproteins ( ldl ) and hdl . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
63,
75
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
122,
151
]
} |
infection with e. acervulina caused ( 1 ) significant reduction in the triglyceride and cholesterol contents of the pm + vldl fraction at 3 and 5 d.p.i. , ( 2 ) significant reduction of ldl cholesterol at 9 d.p.i . and ldl phospholipid at 5-9 d.p.i. , and ( 3 ) significant reduction of hdl cholesterol at 3-9 d.p.i . an... | NA | {
"id": "C0023826",
"name": "cholesterol",
"pos": [
88,
99
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
291,
302
]
} |
most type ii diabetics are overweight at the beginning of the disease and the primary goal of therapy in these patients is normalization of bodyweight and improvement of peripheral and hepatic insulin sensitivity . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
27,
37
]
} | {
"id": "C0005910",
"name": "bodyweight",
"pos": [
140,
150
]
} |
in 11 female patients with chronic uraemia at the age of 20 to 47 years ( average age : 33.1 years ) the behaviour of basal and stimulated serum levels of prolactin ( prl ) , growth hormone ( hgh ) and gonadotropins ( lh , fsh ) was investigated . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
175,
189
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
192,
195
]
} |
[ relation of iron supply and iron metabolism to infectious diseases and parasitoses and the competence of the immune system ] . | NA | {
"id": "C0009450",
"name": "infectious diseases",
"pos": [
49,
68
]
} | {
"id": "C0030499",
"name": "parasitoses",
"pos": [
73,
84
]
} |
in many infectious diseases and in several parasitoses the iron content in the blood plasma occasionally decreases . | NA | {
"id": "C0009450",
"name": "infectious diseases",
"pos": [
8,
27
]
} | {
"id": "C0030499",
"name": "parasitoses",
"pos": [
43,
54
]
} |
the systematic hormone analyses in patients with turner 's syndrome which up to now were not performed in the size demonstrated do not show beyond the gonadotropic regulating circle any clues to practice relevant disturbances of the hypothalamo-pituitary centres of the classical endocrine regulating circles and in the ... | NA | {
"id": "C0014130",
"name": "disturbances",
"pos": [
213,
225
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
245,
254
]
} |
in 1986 every person consumed an average of 11.5 litres of pure alcohol ( 146.4 litres of beer , 23.3 litres of wine and 6.1 litres of spirits ) . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
64,
71
]
} | {
"id": "C0004922",
"name": "beer",
"pos": [
90,
94
]
} |
in 1986 every person consumed an average of 11.5 litres of pure alcohol ( 146.4 litres of beer , 23.3 litres of wine and 6.1 litres of spirits ) . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
64,
71
]
} | {
"id": "C0043188",
"name": "wine",
"pos": [
112,
116
]
} |
[ isradipine ( pn 200-110 ) , a new dihydropyridine calcium antagonist with slight negative inotropic properties in comparison with nifedipine ] . | NA | {
"id": "C0071304",
"name": "isradipine",
"pos": [
2,
12
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonist",
"pos": [
36,
70
]
} |
[ isradipine ( pn 200-110 ) , a new dihydropyridine calcium antagonist with slight negative inotropic properties in comparison with nifedipine ] . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonist",
"pos": [
36,
70
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
132,
142
]
} |
the influence of isradipine ( pn 200-110 ) , a new dihydropyridine calcium antagonist , in comparison to nifedipine and placebo on hemodynamics and left ventricular function was investigated in patients with coronary artery disease ( 10 patients in each group ) . | NA | {
"id": "C0071304",
"name": "isradipine",
"pos": [
17,
27
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium",
"pos": [
51,
74
]
} |
the influence of isradipine ( pn 200-110 ) , a new dihydropyridine calcium antagonist , in comparison to nifedipine and placebo on hemodynamics and left ventricular function was investigated in patients with coronary artery disease ( 10 patients in each group ) . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium",
"pos": [
51,
74
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
105,
115
]
} |
it may be problematic to differentiate between torsade de pointes and polymorphous ventricular tachycardia when describing such a ventricular tachyarrhythmia . | NA | {
"id": "C0040479",
"name": "torsade de pointes",
"pos": [
47,
65
]
} | {
"id": "C0042514",
"name": "ventricular tachyarrhythmia",
"pos": [
130,
157
]
} |
in this study plasma levels of atrial natriuretic peptide and of the catecholamines epinephrine and norepinephrine were investigated in hypertensive patients ( ht ) ( n = 30 ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
84,
95
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
100,
114
]
} |
the same held true for norepinephrine ( p less than 0.05 ) and to a lesser extent for epinephrine ( p = 0.09 ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
23,
37
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
86,
97
]
} |
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