text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
therefore , we studied lipid and lipoprotein levels and their association with claudication in a representative sample of diabetic and non-diabetic subjects in east finland . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
23,
28
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
33,
44
]
} |
in conclusion , our results indicate that in both types of diabetes peripheral vascular disease is associated with lipid and lipoprotein abnormalities favouring atherosclerosis . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
115,
120
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
125,
136
]
} |
the lipid and lipoprotein profile was examined in male patients with acute myocardial infarction ( ami ) at the time of infarction ( group a ) and in male patients who had survived ami 2-3 years before the study ( group b ) , and compared to that of healthy controls . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
4,
9
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
14,
25
]
} |
using a discriminating gradient separation technique combined with careful analysis of lipid and apolipoprotein ( apo ) composition , serum lipoproteins of 20 chronically uremic patients have been compared with those of 19 normal controls matched for age and sex . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
87,
92
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
140,
152
]
} |
a dihematoporphyrin ether-free hematoporphyrin derivative has been prepared by a base-catalysed dehydration of hematoporphyrin with sodium hydroxide . | NA | {
"id": "C0058031",
"name": "dihematoporphyrin ether",
"pos": [
2,
25
]
} | {
"id": "C0121300",
"name": "hematoporphyrin derivative",
"pos": [
31,
57
]
} |
three thiol proteinases , namely papain , chymopapain and proteinase omega were purified to homogeneity from the latex of carica papaya l . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
12,
23
]
} | {
"id": "C0030946",
"name": "proteinase",
"pos": [
58,
68
]
} |
proteinase omega shares 148 identical amino-acid residues ( 68.5 % ) with papain and 108 ones ( 50 % ) with actinidin , including the three disulfide bridges and the free cysteine residue required for activity , as well as most of the other amino-acid residues involved in the catalytic mechanism and two thirds of the g... | NA | {
"id": "C0002520",
"name": "amino-acid",
"pos": [
38,
48
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
319,
326
]
} |
in situ fluoride uptake from 0.05 % neutral naf mouthrinses : effects of a novel enhanced delivery system . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
8,
16
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
44,
47
]
} |
moyamoya ( `` '' puff of smoke '' '' ) syndrome is a disease of children and young adults caused by fibromuscular dysplasia of the internal carotid and proximal cerebral arteries and is rarely associated with hypertension . | NA | {
"id": "C0039082",
"name": ") syndro",
"pos": [
37,
45
]
} | {
"id": "C0012634",
"name": "a disea",
"pos": [
51,
58
]
} |
increasing dietary na at the lower ca intake caused significant ( p less than 0.05 ) increases in parathyroid hormone ( pth ) and 24-hour cyclic amp excretion that were associated with significant ( p less than 0.01 ) increases in erythrocyte intracellular calcium ( from 5.4 +/- 0.7 to 11.1 +/- 3.7 microm ) , ca-atpase... | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
314,
320
]
} | {
"id": "C0001479",
"name": "na/k-atpase",
"pos": [
500,
511
]
} |
in the postaggregation stages , gp80 is replaced by other surface glycoproteins in maintaining cell-cell adhesion . | NA | {
"id": "C0017968",
"name": "gp80",
"pos": [
32,
36
]
} | {
"id": "C0025248",
"name": "surface glycoproteins",
"pos": [
58,
79
]
} |
ferret fibroblasts infected with a cell-associated strain of subacute sclerosing panencephalitis virus were inoculated into the hearts of ferrets in order to study whether the virus can spread from the blood to the brain in this animal model . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
7,
18
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
35,
39
]
} |
interaction of hiv infection with nervous tissue may play a crucial role in the development of aids . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
15,
28
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
95,
99
]
} |
in this note , we first review some of the immunopathogenic mechanisms of hiv infection and discuss the possible role of the idiotypic network in producing immunodeficiency ; | NA | {
"id": "C0019693",
"name": "hiv",
"pos": [
74,
77
]
} | {
"id": "C0021051",
"name": "immunodeficiency",
"pos": [
156,
172
]
} |
the fab negative ion spectra were characterized by clusters incorporating the anion ( e.g . [ m + cl ] - ) but are generally less informative than the spectra obtained in the positive mode . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
17,
20
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
78,
83
]
} |
the ana were restricted to the igg1 and igg3 isotypes as is the case in sle but did not express idiotypes commonly found in this autoimmune disease . | NA | {
"id": "C0024141",
"name": "sle",
"pos": [
72,
75
]
} | {
"id": "C0004364",
"name": "autoimmune disease",
"pos": [
129,
147
]
} |
sequencing of the hplc-purified amyloid protein from ad meninges confirmed the published beta-protein sequence for residues 1-30 and 35-40 , with the exception of glutamic acid rather than glutamine at position 11 . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
163,
176
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
189,
198
]
} |
although d2 receptor density approached control levels in the area of the patches , otherwise the transplanted striatum was relatively empty of dopamine receptors , and overall d2 development of the graft was strikingly reduced from controls . | NA | {
"id": "C0058698",
"name": "d2 receptor",
"pos": [
9,
20
]
} | {
"id": "C0034798",
"name": "dopamine receptors",
"pos": [
144,
162
]
} |
these results imply that the integrity of the dopaminergic projection to the prefrontal cortex is essential for food-hoarding behavior to occur and that food-hoarding activity is not spared after neonatal depletion of dopamine . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
46,
58
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
218,
226
]
} |
a comparison between the two calcium-binding proteins and gaba-immunoreactivity in adult brains revealed different relationships in the two nuclei : while in nucleus rotundus gaba-staining pattern neither resembles that of parvalbumin nor of calbindin , in the nucleus isthmi complex all three staining patterns coincide... | NA | {
"id": "C0006732",
"name": "calcium-binding proteins",
"pos": [
29,
53
]
} | {
"id": "C0054444",
"name": "calbindin",
"pos": [
242,
251
]
} |
infusion of the cholinergic agonist carbamyl-beta-choline ( carbachol ) produced robust , reliable activation of lc neurons at doses of 25-1,000 ng per 100 nl injection . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
16,
23
]
} | {
"id": "C0006945",
"name": "carbachol",
"pos": [
60,
69
]
} |
pretreatment with long acting insulin resulted in a selective depletion of epinephrine stores and acetylcholine-mediated epinephrine release , but did not appear to significantly affect either the levels or the release of norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
75,
86
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
222,
236
]
} |
support of visceral protein synthesis as judged by acute-phase reactant and hepatic protein ( e.g. , transferrin ) synthesis ; | NA | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
51,
71
]
} | {
"id": "C0040679",
"name": "transferrin",
"pos": [
101,
112
]
} |
the inhibitory effect of a single subcutaneous ( s.c. ) dose of three different bisphosphonates ( bps ) -- 4-amino-1-hydroxybutylidene-1,1-bisphosphonate ( ahbubp ) , 2- ( 2-pyridinyl ) -ethylidene-1,1-bisphosphonate ( 2-pebp ) , and dichloromethylene-bisphosphonate ( cl2mbp ) -- was studied in a model of retinoid-indu... | NA | {
"id": "C0012544",
"name": "bisphosphonates",
"pos": [
80,
95
]
} | {
"id": "C0012081",
"name": "dichloromethylene-bisphosphonate",
"pos": [
234,
266
]
} |
administration of gallium nitrate to growing rats results in a dose-dependent accumulation of low levels of gallium in bone that is associated with specific changes in the mineral properties of bone . | NA | {
"id": "C0061008",
"name": "gallium nitrate",
"pos": [
18,
33
]
} | {
"id": "C0016980",
"name": "gallium",
"pos": [
108,
115
]
} |
following short-term treatment ( 14 days ) with gallium nitrate ( 45 mg/kg body weight ) , a significant increase in the relative proportion of more dense bone ( greater than or equal to 2.15 g/cc ) was observed ( 24 % for the control vs. 39 % for the gallium-treated rats , p less than 0.01 ) . | NA | {
"id": "C0061008",
"name": "gallium nitrate",
"pos": [
48,
63
]
} | {
"id": "C0016980",
"name": "gallium",
"pos": [
252,
259
]
} |
alteration in sialidase and other glycosidase activities in the kidney of spontaneously hypertensive rats : persistence after preventive treatment with hydralazine . | NA | {
"id": "C0027803",
"name": "sialidase",
"pos": [
14,
23
]
} | {
"id": "C0017976",
"name": "glycosidase",
"pos": [
34,
45
]
} |
the dermal papilla is established as a permanent and stable population of specialized fibroblasts that first appear as a cellular aggregate that interacts with the epidermis to ensure follicle development . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
86,
97
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
121,
129
]
} |
the unit appears to treat older children as well as those less than 9 , children from fighting families as well as those with less fighting , and sexually abused children as well as physically abused children . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
26,
40
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
200,
208
]
} |
the case of a 27 year old married male foot-fetishist is presented with emphasis on the psychosexual development leading to the specific sexual deviation . | NA | {
"id": "C0015957",
"name": "fetishist",
"pos": [
44,
53
]
} | {
"id": "C0030482",
"name": "sexual",
"pos": [
137,
143
]
} |
a procedure has been developed for the isolation and identification of mutants of the bacterial serine protease , subtilisin , which exhibit enhanced thermostability . | NA | {
"id": "C0036734",
"name": "serine protease",
"pos": [
96,
111
]
} | {
"id": "C0038601",
"name": "subtilisin",
"pos": [
114,
124
]
} |
in this way , a variant of subtilisin has been constructed which is about 12-fold more stable than wild-type subtilisin , with no radical changes in the tertiary protein structure but rather minor , independent alterations in amino acid sequence . | NA | {
"id": "C0038597",
"name": "a",
"pos": [
9,
10
]
} | {
"id": "C0038601",
"name": "subtilisin",
"pos": [
109,
119
]
} |
we are probing the determinants of catalytic function and substrate specificity in serine proteases by kinetic and crystallographic characterization of genetically engineered site-directed mutants of rat trypsin . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
83,
99
]
} | {
"id": "C0041236",
"name": "trypsin",
"pos": [
204,
211
]
} |
the deduced sequence of this protein indicates that it is a cysteine-zinc finger protein supporting the hypothesis that the mal63 gene product is a dna binding protein . | NA | {
"id": "C0033684",
"name": "gene",
"pos": [
130,
134
]
} | {
"id": "C0012940",
"name": "dna binding protein",
"pos": [
148,
167
]
} |
in vivo and in vitro effects of a new macrolide antibiotic roxithromycin on rat liver cytochrome p-450 : comparison with troleandomycin and erythromycin . | NA | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
59,
72
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
140,
152
]
} |
the effects of a new macrolide antibiotic ( roxithromycin ) and one of its major metabolite ( ru 39001 ) on rat hepatic drug metabolizing enzymes were compared to those of erythromycin , erythralosamine and troleandomycin ( tao ) both in vitro and in vivo . | NA | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
44,
57
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
172,
184
]
} |
in contrast to erythromycin , erythralosamine and tao , roxithromycin and its metabolite ru 39001 exhibit : ( i ) a very poor affinity for rat liver cytochrome p-450 , ( ii ) an unability to be metabolized into a stable inhibitory metabolite-cytochrome p-450 complex and ( iii ) a decreased ability to induce liver cytoc... | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
15,
27
]
} | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
56,
69
]
} |
using dietary administration , mice were exposed to eight substances known to cause peroxisome proliferation ( i.e . clofibrate clofibric acid , 2,4-dichlorophenoxyacetic acid , 2,4,5-trichlorophenoxyacetic acid , nafenopin , ici-55.897 , s-8527 and wy-14.643 ) or the related substance p-chlorophenoxyacetic acid ( grou... | NA | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
117,
127
]
} | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
128,
142
]
} |
induction of total microsomal cytochrome p-450 was obtained after dietary exposure to clofibrate , clofibric acid , 2,4-dichlorophenoxyacetic acid , 2,4,5-trichlorophenoxyacetic acid , nafenopin , wy-14.643 , di ( 2-ethylhexyl ) phthalate and di ( 2-ethylhexyl ) phosphate . | NA | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
86,
96
]
} | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
99,
113
]
} |
the most pronounced effects on cytosolic glutathione transferase activity were the decreases obtained after treatment with clofibrate , clofibric acid and wy-14.643 . | NA | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
123,
133
]
} | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
136,
150
]
} |
plasma levels of catecholamines and neuropeptides ( met-enkephalin , me ; neurotensin , nt ; neuropeptide y , npy ; peptide yy , pyy ; vasoactive intestinal polypeptide , vip ; cholecystokinin , cck ; bombesin , bmb ) were examined in the femoral artery ( fa ) , adrenal vein ( ad ) , and portal vein ( pv ) , in eight c... | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
36,
49
]
} | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
74,
85
]
} |
plasma levels of catecholamines and neuropeptides ( met-enkephalin , me ; neurotensin , nt ; neuropeptide y , npy ; peptide yy , pyy ; vasoactive intestinal polypeptide , vip ; cholecystokinin , cck ; bombesin , bmb ) were examined in the femoral artery ( fa ) , adrenal vein ( ad ) , and portal vein ( pv ) , in eight c... | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
36,
49
]
} | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
93,
107
]
} |
following naloxone administration ( s5 ) , the adrenal medullary release of ne , epinephrine ( epi ) , da , nt , and npy was significantly ( twofold ) increased ; | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
16,
18
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
81,
92
]
} |
monoclonal antibodies were raised against type vi collagen isolated from chick embryo gizzard , and these antibodies were used to immunoprecipitate type vi collagen from metabolically labeled embryo cells . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
106,
116
]
} |
these results show that procollagen gene expression by hepatocytes is not directly correlated with their functional state and that corticosteroids differently affect the expression of different collagen genes and collagen deposition . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
24,
35
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
213,
221
]
} |
the recent cloning of two genes for il-1 ( il-1 alpha and beta ) , together with the availability of specific antibodies to these two species of il-1 have allowed their identification as secretory products of a number of other cell types , including b cells . | NA | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
43,
53
]
} | {
"id": "C0021755",
"name": "il-1",
"pos": [
145,
149
]
} |
the calcium antagonists prenylamine and fendiline both bind with rather low affinity to the dihydropyridine ( nifedipine ) binding site . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
92,
107
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
110,
120
]
} |
norfloxacin ( n ) , pefloxacin ( p ) , enoxacin ( e ) , ofloxacin ( o ) , difloxacin ( d ) , ciprofloxacin ( c ) , fleroxacin ( f ) , a-61827 ( a ) , temafloxacin ( t ) and lomefloxacin ( l ) were used in these studies . | NA | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
93,
106
]
} | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
115,
125
]
} |
in clinical trials co-ordinated in italy by glaxo s.p.a. from may 1984 to february 1988 , 553 patients aged over 65 years ( 376 men and 177 women ) , suffering from different infectious diseases ( mostly lrti and uti ) , were treated with ofloxacin , a new broad-spectrum quinolone . | NA | {
"id": "C0009450",
"name": "infectious diseases",
"pos": [
175,
194
]
} | {
"id": "C0042029",
"name": "uti",
"pos": [
213,
216
]
} |
the mean values of aptt rose significantly only after administration of lmw heparin ( 15,000 axau ) , while no relevant variations were observed after ch and lmwh-ld administration . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
76,
83
]
} | {
"id": "C0019139",
"name": "lmwh",
"pos": [
158,
162
]
} |
cefuroxime axetil is a orally active prodrug formulation of cefuroxime , which upon absorption undergoes immediate deesterification to free cefuroxime . | NA | {
"id": "C0055015",
"name": "cefuroxime axetil",
"pos": [
0,
17
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
140,
150
]
} |
clinical studies suggest it is at least as effective as ampicillin , amoxicillin , amoxicillin/clavulanic acid , penicillin v , or cefaclor in the treatment of uncomplicated urinary tract infections , acute otitis media , upper respiratory infections , skin and soft tissue infections , and uncomplicated gonorrhea . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
56,
66
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
83,
94
]
} |
there is very little risk of neurological deficit , epilepsy , mental retardation , or altered behaviour as sequelae to febrile seizures . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
52,
60
]
} | {
"id": "C0009952",
"name": "febrile seizures",
"pos": [
120,
136
]
} |
a preliminary review of its pharmacodynamic and pharmacokinetic properties , and therapeutic efficacy in glaucoma and ocular hypertension . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
105,
113
]
} | {
"id": "C0028840",
"name": "ocular",
"pos": [
118,
124
]
} |
in contrast , the methylindoline compound , indapamide , a diuretic with vasodilator activity , has produced no adverse effects on lipids or lipoproteins . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
131,
137
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
141,
153
]
} |
when affective disorder begins with depressive episodes is it possible to predict future mania and anticipate bp diagnosis ? | NA | {
"id": "C0525045",
"name": "affective disorder",
"pos": [
5,
23
]
} | {
"id": "C0011581",
"name": "depressive episodes",
"pos": [
36,
55
]
} |
reduced nigral gad activity may be a marker of irreversible brain damage and has not been observed in all chronic experiments , but only in individuals with long-standing or irreversible dyskinesia . | NA | {
"id": "C0086439",
"name": "reduced",
"pos": [
0,
7
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
187,
197
]
} |
the gaba part of the td hypothesis has been tested with different gaba agonists such as gamma-acetylenic gaba , gamma-vinyl gaba and thip , but most studies suggest that the therapeutic effect of these drugs in td is limited and maybe secondary to parkinsonism and sedation . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
4,
8
]
} | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
112,
128
]
} |
a case of hypopituitarism due to granulomatous and lymphocytic adenohypophysitis with minimal pituitary enlargement : a possible variant of lymphocytic adenohypophysitis . | NA | {
"id": "C0020635",
"name": "hypopituitarism",
"pos": [
10,
25
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
94,
103
]
} |
we have measured plasma 7b2 ( a novel pituitary protein ) -immunoreactivity ( ir ) concentrations in patients with various endocrine disorders . | NA | {
"id": "C0032002",
"name": "pituitary",
"pos": [
38,
47
]
} | {
"id": "C0014130",
"name": "endocrine disorders",
"pos": [
123,
142
]
} |
evidence from antibiotic mic studies on porin-deficient mutants compared with their porin-sufficient parent strains has provided strong support for the proposal that some antibiotics , particularly beta-lactams , pass across the outer membrane through the water-filled channels of a class of proteins called porins . | NA | {
"id": "C0071728",
"name": "sufficient",
"pos": [
90,
100
]
} | {
"id": "C0599635",
"name": "water",
"pos": [
256,
261
]
} |
severe infection including septicaemia , lower respiratory tract infection , anorectal lesion and urinary tract infection occurred in 32 patients . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
7,
16
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
98,
121
]
} |
a-56268 showed activity comparable to that of erythromycin and was more active than josamycin and roxithromycin against erythromycin-sensitive aerobic and facultatively anaerobic gram-positive cocci . | NA | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
98,
111
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
120,
132
]
} |
the activity of sulbactam/ampicillin , aztreonam , cefetamet , cefixime , ciprofloxacin , enoxacin , fleroxacin and ofloxacin was determined against 160 haemophilus influenzae strains using a standardized microdilution method . | NA | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
74,
87
]
} | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
101,
111
]
} |
from the data obtained with the six new ida derivatives , the distribution kinetics of 99mtc-arclophenin , ( n-n'-2-benzoyl-4-chlorophenyl ) carbamoylmethyl ) imino diacetic acid ( phenida ) , are closely comparable to 99mtc-disofenin in all animal models . | NA | {
"id": "C0020931",
"name": "imino",
"pos": [
159,
164
]
} | {
"id": "C0075932",
"name": "99mtc-disofenin",
"pos": [
219,
234
]
} |
the incidence of arthritis declined in parallel to the decrease in number of children presenting with arf , whereas the incidence of carditis remained the same . | NA | {
"id": "C0003864",
"name": "arthritis",
"pos": [
17,
26
]
} | {
"id": "C0035436",
"name": "arf",
"pos": [
102,
105
]
} |
five infants had hyperinsulinism secondary to nesidioblastosis or to a beta-cell adenoma of the pancreas , one infant had neonatal sepsis due to staphylococcal infection and one infant congenital growth hormone ( hgh ) and adrenocorticotropic hormone ( acth ) deficiency . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
196,
210
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
213,
216
]
} |
in babies with hyperinsulinism , plasma noradrenaline increased from 0.29 +/- 0.03 to 0.61 +/- 0.09 ng/ml ( p less than 0.01 ) , whereas adrenaline increased only in three , but did not change in two babies . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
40,
53
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
137,
147
]
} |
in hypoglycaemia due to congenital sepsis , noradrenaline increased from 0.39 to 1.64 ng/ml and adrenaline from 0.05 to 0.86 ng/ml . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
44,
57
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
96,
106
]
} |
to assess the adrenocortical response of premature infants to alterations in sodium balance , the postnatal course of plasma progesterone , 11-deoxycorticosterone , corticosteronoe , aldosterone , 17-hydroxyprogesterone , 11-deoxycortisol , cortisol and cortisone was compared in healthy premature infants kept on low ( ... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
125,
137
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
197,
219
]
} |
the histological and histochemical examination of biopsies of intestinal mucosa near to and far from the ureteral orifices showed transformations with considerable inflammatory infiltration , variations in the composition of the acid mucins with a prevalence of sialomucins , lengthening and branching of the glandular c... | NA | {
"id": "C0026682",
"name": "mucins",
"pos": [
234,
240
]
} | {
"id": "C0074477",
"name": "sialomucins",
"pos": [
262,
273
]
} |
paraneoplastic syndrome , abdominal mass , tendency to local recurrence , laborious therapy and poor prognosis are the clinical characteristics of this tumor . | NA | {
"id": "C0030472",
"name": "paraneoplastic syndrome",
"pos": [
0,
23
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
152,
157
]
} |
adenosine and its analogs ( 5'-n-ethyl-carboxamide adenosine , neca and n6-l-phenyl-isopropyl adenosine , l-pia ) , produced concentration-dependent relaxations of the tonic contractions and the order of potency was found to be : neca greater than l-pia greater than adenosine . | NA | {
"id": "C0050789",
"name": "neca",
"pos": [
63,
67
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
267,
276
]
} |
three opioid agonists ( [ d-ala2 , n-mephe4 , gly-ol5 ] enkephalin ( dago ) , [ d-pen2 , d-pen5 ] enkephalin ( dpdpe ) and u50488h ) were tested independently for their ability to produce analgesia in the formalin test . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
56,
66
]
} | {
"id": "C0525773",
"name": "dago",
"pos": [
69,
73
]
} |
three opioid agonists ( [ d-ala2 , n-mephe4 , gly-ol5 ] enkephalin ( dago ) , [ d-pen2 , d-pen5 ] enkephalin ( dpdpe ) and u50488h ) were tested independently for their ability to produce analgesia in the formalin test . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
56,
66
]
} | {
"id": "C0525856",
"name": "dpdpe",
"pos": [
111,
116
]
} |
in vascular smooth muscle cells the phorbol ester , 12-o-tetradecanoyl phorbol 13-acetate ( tpa ) , a potent activator of c-kinase , inhibited the accumulation of inositol phosphates and the mobilization of calcium produced by several agonists . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
36,
49
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl phorbol",
"pos": [
52,
78
]
} |
the systemic haemodynamic effects of a 10 min i.v . infusion of three dihydropyridine ca2+ channel blockers , nifedipine ( 1 , 2 and 4 micrograms.kg-1.min-1 ) , nisoldipine ( 0.5 , 1 and 2 micrograms.kg-1.min-1 ) and nimodipine ( 1 , 2 and 4 micrograms.kg-1.min-1 ) were studied in instrumented conscious pigs with or wi... | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
70,
85
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
110,
120
]
} |
the systemic haemodynamic effects of a 10 min i.v . infusion of three dihydropyridine ca2+ channel blockers , nifedipine ( 1 , 2 and 4 micrograms.kg-1.min-1 ) , nisoldipine ( 0.5 , 1 and 2 micrograms.kg-1.min-1 ) and nimodipine ( 1 , 2 and 4 micrograms.kg-1.min-1 ) were studied in instrumented conscious pigs with or wi... | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
70,
85
]
} | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
217,
227
]
} |
the most obvious activating effect on the hormonal status of hhas was characteristic of norepinephrine , less pronounced was the effect of `` '' stress '' '' doses of adrenaline and dopamine , the aforementioned effect was insignificant with dopamine in physiological concentration . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
88,
102
]
} | {
"id": "C0014563",
"name": "adrenali",
"pos": [
167,
175
]
} |
we have examined the effect of triiodothyronine ( t3 ) treatment of the euthyroid rat on serum thyrotrophin ( tsh ) concentration , pituitary content of tsh and on pituitary cytoplasmic levels of tsh beta- and alpha-subunit messenger ( m ) rnas , measured using the technique of dot hybridization to radiolabelled comple... | NA | {
"id": "C0040160",
"name": "thyrotrophin",
"pos": [
95,
107
]
} | {
"id": "C0076641",
"name": "tsh beta",
"pos": [
196,
204
]
} |
the membrane-bound enzyme showed a ph optimum of 5.0 and addition of fatty acyl-coenzymes a ( coas ) , such as oleoyl-coa , palmitoyl-coa and palmitoleoyl-coa , increased [ 3h ] e2-fatty acyl ester formation from [ 3h ] e2 by some 7-fold . | NA | {
"id": "C0001374",
"name": "acyl-coenzymes a",
"pos": [
75,
91
]
} | {
"id": "C0030239",
"name": "palmitoyl-coa",
"pos": [
124,
137
]
} |
in order to further investigate the role of epinephrine and/or norepinephrine in oviduct , the distribution of beta-adrenergic receptors has been studied in the rat oviduct , using in vitro autoradiography and [ 125i ] cyanopindolol ( cyp ) , as radioligand . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
44,
55
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
63,
77
]
} |
levels of hcs-1 gene mrna and hcs release were increased by thyroid hormone , dexamethasone , a cyclic adenosine monophosphate ( camp ) analogue ( 8-bromo-camp ) , and phorbol ester , phorbol-12-myristate-13-acetate ( pma ) . | NA | {
"id": "C0001455",
"name": "cyclic adenosine monophosphate",
"pos": [
96,
126
]
} | {
"id": "C0000661",
"name": "8-bromo-camp",
"pos": [
147,
159
]
} |
levels of hcs-1 gene mrna and hcs release were increased by thyroid hormone , dexamethasone , a cyclic adenosine monophosphate ( camp ) analogue ( 8-bromo-camp ) , and phorbol ester , phorbol-12-myristate-13-acetate ( pma ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
168,
181
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
218,
221
]
} |
from this protein an ha-containing fragment was cleaved out , attached in high copy number to carrier proteins , and used as an immunogen to produce monoclonal antibodies able to recognize head activator in precursor form . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
10,
17
]
} | {
"id": "C0007292",
"name": "carrier",
"pos": [
94,
101
]
} |
the authors report the case of a 76 year-old woman affected by heatstroke complicated by massive liver cell necrosis and fulminant liver failure , with a favorable outcome . | NA | {
"id": "C0001364",
"name": "massive liver cell necrosis",
"pos": [
89,
116
]
} | {
"id": "C0162557",
"name": "fulminant liver failure",
"pos": [
121,
144
]
} |
the reported study investigates the relationship of genital infections , pathobiochemical findings and demographic data to preterm labor , premature rupture of membranes ( prom ) and premature delivery . | NA | {
"id": "C0022876",
"name": "preterm labor",
"pos": [
123,
136
]
} | {
"id": "C0151526",
"name": "premature delivery",
"pos": [
183,
201
]
} |
levels of maternal plasma fibrinogen concentrations in patients with prom were elevated 48 hours after delivery in accordance to the characteristics of acute phase proteins . | NA | {
"id": "C0016006",
"name": "fibrinogen",
"pos": [
26,
36
]
} | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
152,
172
]
} |
in all 11 fetuses , cardiac malformations were present : complete atrioventricular canal with levocardia , situs inversus viscerum , and polysplenia : 5 cases ; | NA | {
"id": "C0018798",
"name": "cardiac malformations",
"pos": [
20,
41
]
} | {
"id": "C0023569",
"name": "levocardia",
"pos": [
94,
104
]
} |
all these cardiac malformations can also cause intrauterine heart failure without heart block except hypoplastic left heart and atrial septal defect . | NA | {
"id": "C0018798",
"name": "cardiac malformations",
"pos": [
10,
31
]
} | {
"id": "C0152101",
"name": "hypoplastic left heart",
"pos": [
101,
123
]
} |
five severe cases of intra-abdominal gynaecological haemorrhage ( four haemorrhages from corpora lutea haemorrhagica and one haemorrhage of the endometritis genitalis externa ) are described in relation to prolonged marcumar therapy . | NA | {
"id": "C0019065",
"name": "intra-abdominal",
"pos": [
21,
36
]
} | {
"id": "C0019080",
"name": "haemorrhage",
"pos": [
125,
136
]
} |
estimates of the heritability of sex-adjusted lipid levels were 0.72 for total cholesterol , 0.79 for hdl cholesterol , 0.69 for hdl2 , 0.20 for hdl3 , 1.06 for ldl cholesterol , and 0.44 for sex-adjusted bmi . | NA | {
"id": "C0023822",
"name": "hdl",
"pos": [
102,
105
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
165,
176
]
} |
the composite plasmid pfhs1 , which consists of the f5 dna fragment of f plasmid and the whole dna of a psc101 derivative that carries a temperature-sensitive mutation for dna replication , was not stably maintained in the hup double mutant at 42 degrees c . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
55,
58
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
241,
242
]
} |
it may be functionally homologous to chymosin but could be a novel mammalian aspartyl protease . | NA | {
"id": "C0035100",
"name": "chymosin",
"pos": [
37,
45
]
} | {
"id": "C0078989",
"name": "aspartyl protease",
"pos": [
77,
94
]
} |
the intron/exon boundaries seen in both this clone and in the bovine pepsin a clones are at the same positions as found in human pepsin a , bovine chymosin and human and mouse renins , further evidence that the general structure of mammalian aspartyl protease genes has been strongly conserved . | NA | {
"id": "C0030909",
"name": "pepsin a",
"pos": [
69,
77
]
} | {
"id": "C0078989",
"name": "aspartyl protease",
"pos": [
242,
259
]
} |
the intron/exon boundaries seen in both this clone and in the bovine pepsin a clones are at the same positions as found in human pepsin a , bovine chymosin and human and mouse renins , further evidence that the general structure of mammalian aspartyl protease genes has been strongly conserved . | NA | {
"id": "C0035100",
"name": "chymosin",
"pos": [
147,
155
]
} | {
"id": "C0078989",
"name": "aspartyl protease",
"pos": [
242,
259
]
} |
we have determined the amount of dna from the c end of phage mu present in one of these phages , lambda placmu3 , and have shown that this phage carries a 3137-bp fragment of mu dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
33,
36
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
180,
181
]
} |
the best concentration of glutathione for simultaneous visualization of glutathione peroxidase in mouse liver homogenates and also it is specific for glutathione peroxidase since other peroxidases such as lactoperoxidase , horseradish peroxidase and glutathione s-transferase can not be visualized . | NA | {
"id": "C0017822",
"name": "glutathione peroxidase",
"pos": [
72,
94
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
185,
196
]
} |
the best concentration of glutathione for simultaneous visualization of glutathione peroxidase in mouse liver homogenates and also it is specific for glutathione peroxidase since other peroxidases such as lactoperoxidase , horseradish peroxidase and glutathione s-transferase can not be visualized . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
185,
196
]
} | {
"id": "C0022948",
"name": "lactoperoxidase",
"pos": [
205,
220
]
} |
the best concentration of glutathione for simultaneous visualization of glutathione peroxidase in mouse liver homogenates and also it is specific for glutathione peroxidase since other peroxidases such as lactoperoxidase , horseradish peroxidase and glutathione s-transferase can not be visualized . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
185,
196
]
} | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
223,
245
]
} |
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