text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
rna binding proteins partially constitute the ribonucleoprotein or protein machinery for rna processing ( splicing , polyadenylation and 3 ' end formation ) , transport , and storage . | NA | {
"id": "C0085177",
"name": "rna binding proteins",
"pos": [
0,
20
]
} | {
"id": "C0035544",
"name": "ribonucleoprotein",
"pos": [
46,
63
]
} |
the pattern of proteins associated with 32p-5s rrna is obtained by covalent transfer of 32p-nucleotides from rna to the proteins with which the rna was bound . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
47,
51
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
144,
147
]
} |
in other studies , analysis of secretory products from pure cultures of serous gland cells has revealed that the major glycoconjugates released by this cell type are chondroitin sulfate proteoglycans , hyaluronic acid and n-linked glycoproteins of complex type . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
119,
134
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
231,
244
]
} |
difficulty is sometimes encountered in distinguishing between pleomorphic adenoma , adenoid cystic carcinoma and adenocarcinoma , especially in small biopsies from salivary glands . | NA | {
"id": "C0010606",
"name": "adenoid cystic carcinoma",
"pos": [
84,
108
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
113,
127
]
} |
the differences between the numbers of agnors in the benign and malignant groups , notably pleomorphic adenomas , adenoid cystic carcinoma and adenocarcinoma , were highly significant . | NA | {
"id": "C0010606",
"name": "adenoid",
"pos": [
114,
121
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
143,
157
]
} |
the present intestinal perfusion studies with labelled glucose indicate that the blood glucose homeostatis in vrv treated animals is brought about by a significant reduction in the rate of glucose absorption in the intestine . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
81,
94
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
189,
196
]
} |
one hundred seventy-five clinical isolates of haemophilus influenzae ( including 74 beta-lactamase-producing strains ) were examined for susceptibility to ampicillin , cefonicid , cefamandole , cefuroxime and cefotaxime . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
194,
204
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
209,
219
]
} |
however , cefonicid , cefuroxime and cefotaxime were all more active against beta-lactamase-producing h. influenzae than cefamandole ( mic90 = 1.0 mg/l for cefonicid , mic90 = 2.0 mg/l for cefuroxime , mic90 = 0.01 mg/l for cefotaxime , mic90 = 5.0 mg/l for cefamandole ) . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
22,
32
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
224,
234
]
} |
augmentin achieved a satisfactory clinical response ( cure or improvement ) in 96.7 % of the infections treated , with the following response rates for the five major categories of infection : respiratory tract infections 97.0 % , urinary tract infections 97.8 % , pelvic inflammatory disease 100 % , septicaemia 91.4 % ... | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
93,
102
]
} | {
"id": "C0035243",
"name": "respiratory tract infections",
"pos": [
193,
221
]
} |
augmentin achieved a satisfactory clinical response ( cure or improvement ) in 96.7 % of the infections treated , with the following response rates for the five major categories of infection : respiratory tract infections 97.0 % , urinary tract infections 97.8 % , pelvic inflammatory disease 100 % , septicaemia 91.4 % ... | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
93,
102
]
} | {
"id": "C0042029",
"name": "urinary tract",
"pos": [
231,
244
]
} |
augmentin achieved a satisfactory clinical response ( cure or improvement ) in 96.7 % of the infections treated , with the following response rates for the five major categories of infection : respiratory tract infections 97.0 % , urinary tract infections 97.8 % , pelvic inflammatory disease 100 % , septicaemia 91.4 % ... | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
93,
102
]
} | {
"id": "C0149778",
"name": "soft tissue infections",
"pos": [
333,
355
]
} |
there was a striking correlation of gentamicin resistance and the total national aminoglycoside and national gentamicin consumption . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
81,
95
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
109,
119
]
} |
in addition , there was a clear correlation between bacterial resistance inside and outside the hospital to the total amount of aminoglycoside , particularly gentamicin , consumption in hospitals . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
128,
142
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
158,
168
]
} |
structural requirements for hydantoins and 2-thiohydantoins to induce lymphoproliferative popliteal lymph node reactions in the mouse . | NA | {
"id": "C0020209",
"name": "hydantoins",
"pos": [
28,
38
]
} | {
"id": "C0039903",
"name": "thiohydantoins",
"pos": [
45,
59
]
} |
the ability of a large number of hydantoins and 2-thiohydantoins to induce primary local lymphoproliferative popliteal lymph node ( pln ) reactions has been investigated , as judged by pln weight enlargement , in an attempt to evaluate the discriminating potential of the pln reaction to low mol . wt chemicals and to es... | NA | {
"id": "C0020209",
"name": "hydantoins",
"pos": [
33,
43
]
} | {
"id": "C0039903",
"name": "thiohydantoins",
"pos": [
50,
64
]
} |
among a series of nineteen hydantoins and related compounds only 5,5-diphenylhydantoin ( phenytoin ) , its major metabolite 5- ( p-hydroxyphenyl ) -5-phenylhydantoin , 5,5-diphenyl-2-thiohydantoin and n- ( 5-nitro-2-furfurylidene ) -1-aminohydantoin ( nitro-furantoin ) elicited marked pln reactions in c57bl/6j mice . | NA | {
"id": "C0020209",
"name": "hydantoins",
"pos": [
27,
37
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
89,
98
]
} |
there are special issues in the management of psychopathology in the setting of epilepsy such as the relative seizure threshold lowering effects of psychotropic drugs and the behavioral effects of altering the seizure control . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
80,
88
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
210,
217
]
} |
in a previous study of epileptic phenomena in 19 patients with partial complex seizures , it was noted that seizures of left temporal lobe origin had a higher incidence of secondary generalization . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
23,
32
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
108,
116
]
} |
this study was designed to re-examine the circadian profiles of dopamine , noradrenaline and adrenaline in the plasma and to investigate the influence of daytime noise stress on these profiles . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
75,
88
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
93,
103
]
} |
a significant ( p less than 0.001 ) circadian rhythm was found for free noradrenaline , free adrenaline and conjugated dopamine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
72,
85
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
93,
103
]
} |
noise stress significantly increased ( p less than 0.001 ) free adrenaline levels during the first 6 h of exposure and lowered ( p less than 0.001 ) free noradrenaline values during the whole time of exposure ; | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
64,
74
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
154,
167
]
} |
in other cardiac disorders ( rheumatic valvulopathies , arrhythmias etc . ) this risk is independent from arterial damage , and the risk subsequent to an associated carotid stenosis does not differ from that of the general population . | NA | {
"id": "C0018799",
"name": "cardiac disorders",
"pos": [
9,
26
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
56,
67
]
} |
[ emergency bypass operation following unsuccessful percutaneous transluminal coronary angioplasty : how important is ischemia time in preventing an infarct ? ] . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
118,
126
]
} | {
"id": "C0021308",
"name": "infarct",
"pos": [
149,
156
]
} |
these results indicate that the antigen is produced by clear cells of the epididymal epithelium , that the antigenic determinant is masked initially by sialic acid residues , and that expression of the antigenic determinant on the sperm surface during epididymal maturation apparently involves desialylation . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
32,
39
]
} | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
202,
223
]
} |
using isolated submucosal glands from feline trachea , we examined the effect of vasoactive intestinal peptide ( vip ) on mucus glycoprotein secretion and glandular contraction by measuring released radiolabeled glycoconjugates and induced tension , respectively . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
128,
140
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
212,
227
]
} |
to determine whether neutral endopeptidase ( nep ) , also called enkephalinase ( ec 3.4.24.11 ) , modulates the effects of exogenous and endogenous tachykinins in vivo , we studied the effects of aerosolized phosphoramidon , a specific nep inhibitor , on the responses to aerosolized substance p ( sp ) and on the atropi... | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
148,
159
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
284,
295
]
} |
preexposure to hypoxia increased survival and lung reduced glutathione-to-oxidized glutathione ratios ( gsh/gssg ) and decreased pleural effusions in rats subsequently exposed to continuous hyperoxia . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
104,
107
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
108,
112
]
} |
second , after perfusion with go , lungs from hypoxia-preexposed rats had increased h2o2 reducing equivalents , as reflected by increased gsh/gssg and nadph/nadph+ , compared with lungs from normoxia-preexposed rats . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
138,
141
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
142,
146
]
} |
the distribution of these enzymes appears to be heterogeneous in the hepatic lobule , and the specific isoenzyme that predominates is influenced by sex steroid levels in the animal . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
26,
33
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
103,
112
]
} |
the objective of this study is to alter the fiber morphology of a linear aliphatic polyester , polyglycolic acid , by annealing treatment and to examine the changes of its degradation properties . | NA | {
"id": "C0032474",
"name": "polyester",
"pos": [
83,
92
]
} | {
"id": "C0032502",
"name": "polyglycolic acid",
"pos": [
95,
112
]
} |
gas chromatographic analysis revealed that polyunsaturated fatty acids such as arachidonic acid and total tissue free fatty acids isolated from an aminopropyl bonded-phase column yield a two- to three-fold higher recovery of arachidonic acid as compared to those isolated from thin-layer chromatographic plates . | NA | {
"id": "C0003701",
"name": "acids",
"pos": [
65,
70
]
} | {
"id": "C0003695",
"name": "arachidonic",
"pos": [
225,
236
]
} |
in addition to the formation of biliverdin , attention was also paid to accompanying processes affecting the reaction mechanism , which were explained as aggregation and dimerization of bilirubin and biliverdin . | NA | {
"id": "C0005437",
"name": "bilirubin",
"pos": [
186,
195
]
} | {
"id": "C0005446",
"name": "biliverdin",
"pos": [
200,
210
]
} |
high-performance liquid chromatographic assay for the simultaneous measurement of two spironolactone analogues , 17 beta-hydroxy-3-oxo-17-pregn-4-ene-21-carboxylic acid-gamma-lactone 7 alpha-methyl ethyl ester and its 6 beta-hydroxylated derivative . | NA | {
"id": "C0037982",
"name": "spironolactone",
"pos": [
86,
100
]
} | {
"id": "C0022947",
"name": "lactone",
"pos": [
175,
182
]
} |
determination of k vitamins ( phylloquinone and menaquinones ) in umbilical cord plasma by a platinum-reduction column . | NA | {
"id": "C0042878",
"name": "k vitamins",
"pos": [
17,
27
]
} | {
"id": "C0086605",
"name": "menaquinones",
"pos": [
48,
60
]
} |
a gas chromatographic-mass spectrometric screening procedure is described for the identification and differentiation of the following alkylamine antihistamines and their metabolites in urine : azatadine , benzquinamide , brompheniramine , chlorphenamine , ( clofedanol ) , cyproheptadine , dimetindene , ketotifen , mebh... | NA | {
"id": "C0006246",
"name": "brompheniramine",
"pos": [
221,
236
]
} | {
"id": "C0031408",
"name": "pheniramine",
"pos": [
346,
357
]
} |
a gas chromatographic-mass spectrometric screening procedure is described for the identification and differentiation of the following alkylamine antihistamines and their metabolites in urine : azatadine , benzquinamide , brompheniramine , chlorphenamine , ( clofedanol ) , cyproheptadine , dimetindene , ketotifen , mebh... | NA | {
"id": "C0008281",
"name": "chlorphenamine",
"pos": [
239,
253
]
} | {
"id": "C0031408",
"name": "pheniramine",
"pos": [
346,
357
]
} |
a simple post-column derivatization method for the fluorometric determination of biguanides ( buformin and phenformin ) in serum by high-performance liquid chromatography is described . | NA | {
"id": "C0005382",
"name": "biguanides",
"pos": [
81,
91
]
} | {
"id": "C0006359",
"name": "buformin",
"pos": [
94,
102
]
} |
a simple post-column derivatization method for the fluorometric determination of biguanides ( buformin and phenformin ) in serum by high-performance liquid chromatography is described . | NA | {
"id": "C0005382",
"name": "biguanides",
"pos": [
81,
91
]
} | {
"id": "C0031404",
"name": "phenformin",
"pos": [
107,
117
]
} |
after rna is submitted first to rnase t1 and after that to rnase u2 it is cleaved into oligopyrimidine nucleotides carrying purine nucleotides only at their 3'-terminal . | NA | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
103,
114
]
} | {
"id": "C0034137",
"name": "purine nucleotides",
"pos": [
124,
142
]
} |
application of the method to butter and margarine samples permitted detection of free fatty acids down to 35 ppm and in orange juice , down to 0.5 ppm using only an organic solvent extraction without further sample clean-up for isolation of the fatty acids . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
81,
97
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
245,
256
]
} |
in addition to the increased number of bands in the leg type troponin t region , the presence of two other protein bands ( neonatal forms ) with slower electrophoretic mobility than the other fast isoforms of troponin t , was detected in post-hatch pectoral muscle tested at 1-12 weeks of age . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
107,
114
]
} | {
"id": "C0597298",
"name": "isoforms",
"pos": [
197,
205
]
} |
this study was conducted to assess acute oral dose-responses of four dose levels ( 2.5 , 5 , 10 , 20 mg ) of isradipine , a new calcium channel blocking agent of the 1,4-dihydropyridine group . | NA | {
"id": "C0071304",
"name": "isradipine",
"pos": [
109,
119
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
170,
185
]
} |
the changes in maternal and fetal plasma concentrations of pregnenolone , 17 alpha-hydroxypregnenolone , dehydro-epiandrosterone and their respective sulphates were not significantly altered by the administration of progestagens during induction of delivery . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
59,
71
]
} | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
74,
102
]
} |
patients with mrsa bacteraemia were significantly more likely than those with methicillin-sensitive s. aureus bacteraemia to have had a severe underlying disease , a poor clinical prognosis , prolonged hospitalization , and prior antimicrobial therapy , especially with aminoglycosides . | NA | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
230,
243
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
270,
285
]
} |
a personal computer-based arrhythmia generator has been developed based upon mathematical models of modulated parasystole and the related equations . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
26,
36
]
} | {
"id": "C0206068",
"name": "parasystole",
"pos": [
110,
121
]
} |
gel filtration of serially collected plasma samples indicated that , with time , there was a transition from mercaptan sensitive to high mol wt mercaptan and protein solubilizer resistant selenoproteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
158,
165
]
} | {
"id": "C0074302",
"name": "selenoproteins",
"pos": [
188,
202
]
} |
four amino acids -- alanine , 2,3-diaminopropionic acid , cystine , and cystein -- and also one diamine , ethylenediamine , were chelated with 99m-technetium ( 99mtc ) , and their renal excretion patterns were studied in rabbits in the presence and absence of two renal tubular transport inhibitors , probenecid and 2,4-... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
5,
16
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
20,
27
]
} |
we excluded 54 patients with prolonged runs of atrial fibrillation or supraventricular tachycardia because these arrhythmias reduce the possibility of determining the number of premature beats . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
113,
124
]
} | {
"id": "C0340464",
"name": "premature beats",
"pos": [
177,
192
]
} |
hypertension combined with diabetes in the elderly is characterized by many important metabolic and cardiovascular changes , among which insulin resistance , hyperinsulinaemia and increased total peripheral resistance appear to be the most relevant . | NA | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
137,
155
]
} | {
"id": "C0020459",
"name": "hyperinsulinaemia",
"pos": [
158,
175
]
} |
blood pressure and the heart rate were automatically recorded and blood samples were collected for plasma renin activity and plasma epinephrine and norepinephrine assays . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
132,
143
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
148,
162
]
} |
in order to evaluate the frequency of sexual transmission of human immunodeficiency virus ( hiv ) among promiscuous heterosexuals , we studied the prevalence of hiv infection among a group of predominantly caucasian call girls and women working for escort services and massage parlors in new york city . | NA | {
"id": "C0021051",
"name": "immunodeficiency",
"pos": [
67,
83
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
161,
174
]
} |
three different epitopes were defined by the eight mabs when an antigen-catching elisa was used as the test system . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
16,
24
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
64,
71
]
} |
an antigen-catching elisa for p24 was developed by use of two of the mabs defining two different epitopes . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
3,
10
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
97,
105
]
} |
insulin , proinsulin and desoctapeptide insulin all inhibited the association and degradation of 125i-insulin by bbv , but these processes were not appreciably affected by the insulin-like growth factors igf-i and igf-ii or by cytochrome c and lysozyme , low molecular weight , filterable , proteins , which are known to... | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
10,
20
]
} |
insulin , proinsulin and desoctapeptide insulin all inhibited the association and degradation of 125i-insulin by bbv , but these processes were not appreciably affected by the insulin-like growth factors igf-i and igf-ii or by cytochrome c and lysozyme , low molecular weight , filterable , proteins , which are known to... | NA | {
"id": "C0021665",
"name": "insulin-like growth factors",
"pos": [
176,
203
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
214,
217
]
} |
insulin , proinsulin and desoctapeptide insulin all inhibited the association and degradation of 125i-insulin by bbv , but these processes were not appreciably affected by the insulin-like growth factors igf-i and igf-ii or by cytochrome c and lysozyme , low molecular weight , filterable , proteins , which are known to... | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
204,
207
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
214,
220
]
} |
the mauriceville and varkud mitochondrial plasmids of neurospora are closely related , closed circular dnas ( 3.6 and 3.7 kb , respectively ; 1 kb = 10 ( 3 ) bases or base-pairs ) , whose characteristics suggest relationships to mitochondrial dna introns and retrotransposons . | NA | {
"id": "C0012925",
"name": "circular dnas",
"pos": [
94,
107
]
} | {
"id": "C0012929",
"name": "mitochondrial dna",
"pos": [
229,
246
]
} |
remarkably , we find that the 4.9 kb transcript is a hybrid rna consisting of the full-length 3.7 kb varkud plasmid transcript plus a 5 ' leader of 1.2 kb that is derived from the 5 ' end of the mitochondrial small rrna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
60,
63
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
215,
219
]
} |
deletions of dna flanking the upstream activation sequence left the array unaltered , showing that nucleosome positioning was not a consequence of sequence-specific histone-dna interactions but depended on proximity to the galactose-responsive upstream activation sequence ( uasg ) . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
13,
16
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
276,
277
]
} |
the results of these studies demonstrate that propranolol pre-treatment significantly enhances the in vitro response to the dihydropyridine calcium channel blocker nifedipine , but not the thiazapine calcium channel blocker diltiazem . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium channel blocker",
"pos": [
124,
163
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
164,
174
]
} |
using different monoclonal antibodies specific for the embryonic and the neonatal skeletal myosin heavy chain types we investigated the myosin composition of the rat sino-atrial and atrio-ventricular nodes . | NA | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
91,
109
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
136,
142
]
} |
after 6 to 8 weeks of feeding the myocardial creatine ( cr ) and phosphocreatine ( pcr ) stores were severely depleted while atp content was normal . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
45,
53
]
} | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
65,
80
]
} |
the extent of the contractile failure was found to depend on functional load and on the degree of cr ( pcr ) substitution . | NA | {
"id": "C0010286",
"name": "cr",
"pos": [
98,
100
]
} | {
"id": "C0031634",
"name": "pcr",
"pos": [
103,
106
]
} |
our results show that activated microglia lack monocyte/macrophage antigens recognized by the monoclonal antibodies ox-41 , ed1 , ed2 , and ki-m2r but express high levels of cr3 complement receptors in situ . | NA | {
"id": "C0079785",
"name": "cr3",
"pos": [
174,
177
]
} | {
"id": "C0034793",
"name": "complement receptors",
"pos": [
178,
198
]
} |
in previous work , we found that the phorbol ester drug 12-o-tetradecanoyl phorbol acetate ( tpa ) reverses the developmental restriction of melanogenesis that occurs early in neural crest development , causing schwann cell precursors to undergo a metaplastic transformation into melanocytes . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
37,
50
]
} | {
"id": "C0039654",
"name": "tetradecanoyl",
"pos": [
61,
74
]
} |
the antigen recognized by all three mabs appears to be the same whether the immunogen used to produce the antibodies was cg neurons or nc cells . | NA | {
"id": "C0003250",
"name": "mabs",
"pos": [
36,
40
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
106,
116
]
} |
here we report that the cg-1 and cg-4 antibodies , used in the same ratios in which they are synergistically cytotoxic for both the cg and nc cells ( barald , 1988 ) , and mab cg-14 alone , have specific effects on the high-affinity choline uptake mechanism ( hacu ) of cg neurons and isolated antigen-positive nc cells ... | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
38,
48
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
172,
175
]
} |
the cellular composition of the subcultures was analyzed immunocytochemically over a period of 3 weeks using various combinations of antibodies , recognizing a set of differentiated and a set of undifferentiated glial antigens ( glial fibrillary acidic protein [ gfap ] , galactocerebroside , sulfatide , gangliosides bi... | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
133,
143
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
330,
351
]
} |
in this paper we present evidence that the 48-kd intermediate filament-associated protein ( ifap ) is expressed relatively late in maturation of astrocytes , after they have acquired the glial fibrillary acidic protein ( gfap ) . | NA | {
"id": "C0021769",
"name": "intermediate",
"pos": [
49,
61
]
} | {
"id": "C0017626",
"name": "glial fibrillary acidic protein",
"pos": [
187,
218
]
} |
in the periventricular region and the hippocampus the 48-kd ifap was detected at p6 , long after the appearance of gfap . | NA | {
"id": "C0021769",
"name": "ifap",
"pos": [
60,
64
]
} | {
"id": "C0017626",
"name": "gfap",
"pos": [
115,
119
]
} |
in adult mice the 48-kd ifap was observed in gfap-positive astrocytes in the white matter of cerebellum , spinal cord , brainstem , and corpus callosum as well as in gfap-positive cells in the grey matter of cerebral cortex and spinal cord . | NA | {
"id": "C0021769",
"name": "ifap",
"pos": [
24,
28
]
} | {
"id": "C0017626",
"name": "gfap",
"pos": [
166,
170
]
} |
expression of mrnas for the two major myelin proteins , myelin basic protein ( mbp ) and proteolipid protein ( plp ) , was examined in a number of regions of the developing mouse brain using in situ hybridization . | NA | {
"id": "C0026972",
"name": "myelin proteins",
"pos": [
38,
53
]
} | {
"id": "C0014063",
"name": "myelin basic protein",
"pos": [
56,
76
]
} |
a complex of integral membrane glycoproteins mediates cell binding to the extracellular glycoproteins fibronectin and laminin ( horwitz et al. , j cell biol 101:2134-2144 , 1985 ) . | NA | {
"id": "C0025248",
"name": "membrane glycoproteins",
"pos": [
22,
44
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
88,
101
]
} |
radioimmunoassay of medium from pc12 cultures indicates that intact cells produce and release increased amounts of prostaglandin ( pge ) in response to ngf . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
115,
128
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
131,
134
]
} |
the findings further underline the specificity of ngf action in the central nervous system and , in particular , do not support the idea of transmitter-specific neurotrophic factors . | NA | {
"id": "C0027752",
"name": "ngf",
"pos": [
50,
53
]
} | {
"id": "C0027754",
"name": "neurotrophic factors",
"pos": [
161,
181
]
} |
click-evoked oto-acoustic emissions ( eoes ) and speech audiometry were recorded in a group of normally hearing subjects ( n = 56 ears ) , and a group of patients demonstrating sensorineural hearing loss due to presbycusis ( n = 39 ears ) . | NA | {
"id": "C0018784",
"name": "sensorineural hearing loss",
"pos": [
177,
203
]
} | {
"id": "C0033074",
"name": "presbycusis",
"pos": [
211,
222
]
} |
in this review , we will discuss different aspects of modified lipid and protein metabolism : exchanges between exogenous fat particles and lipoproteins ; | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
63,
68
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
140,
152
]
} |
antibacterial activity of gentamicin ( gm ) , along with activities of other aminoglycosides and beta-lactams , was studied against clinical isolates collected from pediatric patients during a period of may 1986-april 1987 . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
26,
36
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
77,
92
]
} |
neither those arrhythmias occurring later in the ischaemia period ( phase 1b ) nor the total number of single ectopics and salvos or the incidence and duration of ventricular tachycardia was modified by l655,240 . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
14,
25
]
} | {
"id": "C0340464",
"name": "ectopics",
"pos": [
110,
118
]
} |
blood pressure and heart rate and the plasma concentrations of magnesium , potassium ( k+ ) , glucose , lactate , renin activity , norepinephrine , and epinephrine were determined . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
131,
145
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
152,
163
]
} |
in the pha-leukocyte feeder colony assay -- a fluid assay on top of an agar underlayer -- colonies might not be the product of clonogenic cells but rather from aggregates , as was already shown for hairy cell leukemia ( leukemia res . 11 , 911 ( 1987 ) ) . | NA | {
"id": "C0023443",
"name": "hairy cell leukemia",
"pos": [
198,
217
]
} | {
"id": "C0023418",
"name": "res",
"pos": [
229,
232
]
} |
vasopressin and oxytocin excretion in the brown-norway rat in relation to aging , water metabolism and testosterone . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
25,
34
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
88,
98
]
} |
in order to study age-related changes in vasopressin ( vp ) and oxytocin ( ot ) excretion in relation to water metabolism , six young ( 4 months ) and 12 aged ( 34 months ) male brown-norway rats were placed in metabolism cages . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
80,
89
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
211,
221
]
} |
[ toxic properties of lipopolysaccharide and lipid a of aeromonas sobria and non 01 vibrio cholerae ] . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
22,
40
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
45,
52
]
} |
liver adenosine triphosphate and ph in fasted and well-fed mice after infusion of adenine nucleotide precursors . | NA | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
6,
28
]
} | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
82,
100
]
} |
the results suggest an effect of verotoxins on endothelial cells and support the concept of these toxins as virulence factors in e. coli . | NA | {
"id": "C0040549",
"name": "toxins",
"pos": [
37,
43
]
} | {
"id": "C1136170",
"name": "virulence factors",
"pos": [
108,
125
]
} |
drug-related antibodies are responsible for the neutropenia in the so-called 'immune ' or 'aminopyrine ' type of agranulocytosis . | NA | {
"id": "C0023530",
"name": "neutropenia",
"pos": [
48,
59
]
} | {
"id": "C0001824",
"name": "agranulocytosis",
"pos": [
113,
128
]
} |
activin , which stimulates the secretion of fsh from anterior pituitary cells , is a dimer of the beta-subunits of inhibin . | NA | {
"id": "C0050668",
"name": "activin",
"pos": [
0,
7
]
} | {
"id": "C0106025",
"name": "beta-subunits",
"pos": [
98,
111
]
} |
we find that immunopurified untransformed hormone-free receptors , which have a characteristic triplet b , singlet a structure , are phosphoproteins with similar levels of phosphate incorporation in all protein bands . | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
133,
148
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
203,
210
]
} |
we used complement dependent liposome lysis assay for screening mabs and antibodies that bind to pi ( 4,5 ) p2 but not to phosphatidylinositol 4-monophosphate [ pi ( 4 ) p ] were selected . | NA | {
"id": "C0003250",
"name": "mabs",
"pos": [
64,
68
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
73,
83
]
} |
this indicates that the antibody is a murine autoantibody reactive with various animal mts and recognizes a common structure of the various mts . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
24,
32
]
} | {
"id": "C0004358",
"name": "autoantibody",
"pos": [
45,
57
]
} |
this procedure takes into account the problems of insufficient antigen , single epitope immunodominance and the difficulty of mapping non-sequential determinants . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
63,
70
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
80,
87
]
} |
under these conditions , [ 3h ] 5-ht labelled a population of `` '' 5-ht1-like '' '' sites which display nanomolar affinity for tryptamines ( 5-carboxamidotryptamine greater than 5-ht greater than or equal to 5-methoxytryptamine greater than tryptamine ) and some ergolines ( metergoline greater than methysergide ) . | NA | {
"id": "C0036751",
"name": "5-ht",
"pos": [
32,
36
]
} | {
"id": "C0000589",
"name": "5-methoxytryptami",
"pos": [
209,
226
]
} |
under these conditions , [ 3h ] 5-ht labelled a population of `` '' 5-ht1-like '' '' sites which display nanomolar affinity for tryptamines ( 5-carboxamidotryptamine greater than 5-ht greater than or equal to 5-methoxytryptamine greater than tryptamine ) and some ergolines ( metergoline greater than methysergide ) . | NA | {
"id": "C0014699",
"name": "e ergolin",
"pos": [
262,
271
]
} | {
"id": "C0025641",
"name": "( metergoli",
"pos": [
274,
285
]
} |
no inhibition of this activity by lca-unrelated monoclonal antibodies ( such as anti-mhc class i and class ii antibodies ) was observed . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
48,
69
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
110,
120
]
} |
moreover , addition of the placental fraction representing a specific band of 119 kda resulted in the production of allo-immune sera rich in daad antibodies , which , however , were not associated with allograft enhancement . | NA | {
"id": "C0020960",
"name": "immune sera",
"pos": [
121,
132
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
146,
156
]
} |
in the 20 biopsies performed we observed : 14 cases of extramembranous glomerulonephritis , 2 cases of minimal glomerular lesions , 3 cases of segmental focal glomerulosclerosis and 1 periarteritis nodosa . | NA | {
"id": "C0017658",
"name": "glomerulonephritis",
"pos": [
71,
89
]
} | {
"id": "C0017668",
"name": "segmental focal glomerulosclerosis",
"pos": [
143,
177
]
} |
gamma-vinyl gaba had no effect on cholinergic markers but , at 1300 micrograms/ml , increased gaba levels to 135 % of control despite the reduction of glutamate decarboxylase to 68 % of control . | NA | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
0,
16
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
94,
98
]
} |
activity of the synthetase which was greatest in fetal life , fell steadily with fetal maturation from 3.90 +/- 0.06 nmol/mg dna at 16 days , to reach a nadir of 1.36 +/- 0.09 nmol/mg dna on the 4th postnatal day . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
125,
128
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
210,
211
]
} |
significant increases in locomotion occurred when gaba ( 300 micrograms ) was injected along with the inhibitor of gaba-transaminase , d , l-gamma-vinyl-gaba ( gvg ; 5 micrograms ) and the inhibitor of the uptake of gaba , 1-2,4-diaminobutyric acid ( daba ; 5 micrograms ) . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
50,
54
]
} | {
"id": "C0048044",
"name": "gamma-vinyl-gaba",
"pos": [
141,
157
]
} |
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