text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
ten patients ( 18 % ) had delayed cerebral ischemia , totally reversible in 6 cases , with small infarcts in 3 cases , and with 1 death ( 2 % mortality from delayed ischemia ) , there were 5 cases of shunted hydrocephalus , and 3 deaths from other complications . | NA | {
"id": "C0021308",
"name": "infarcts",
"pos": [
97,
105
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
165,
173
]
} |
a marked depletion of neuropeptide k and neurokinin b content was observed when the tachykinin content of the nigral slices was examined before and after stimulation . | NA | {
"id": "C0027847",
"name": "neurokinin b",
"pos": [
41,
53
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
84,
94
]
} |
both the acetylated and non-acetylated forms of melanocyte stimulating hormone ( alpha-melanocyte stimulating hormone and des-acetyl melanocyte stimulating hormone ) stimulate sexual behaviour ; | NA | {
"id": "C0002302",
"name": "alpha-melanocyte",
"pos": [
81,
97
]
} | {
"id": "C0026667",
"name": "melanocyte stimulating hormone",
"pos": [
133,
163
]
} |
in the first method , 6-micron frozen sections of a normal and a hemi-denervated gluteus muscle were stained by an indirect immunoperoxidase method using a rabbit-derived polyclonal antiserum to neural adhesion molecule as the primary antibody . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
182,
191
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
235,
243
]
} |
gaba , muscimol , taurine and pentobarbital ( pb ) dose-dependently induced a transient cl- current ( icl ) , while baclofen and diazepam ( dzp ) did not elicit any currents . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
0,
4
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
116,
124
]
} |
the potency order of the drugs in reducing ica was muscimol greater than gaba = dzp greater than baclofen greater than pb greater than taurine . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
73,
77
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
97,
105
]
} |
mice exposed only to larvae reacted with larval antigens and to a minor degree to somatic adult worm antigens while those mice which were exposed only to adult worms failed to react with any of the antigen preparations . | NA | {
"id": "C0003331",
"name": "worm",
"pos": [
96,
100
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
198,
205
]
} |
amoxicillin ( or ampicillin ) has been the standard for infants and children with acute otitis media because it is safe and effective for most of the causative bacterial pathogens . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
0,
11
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
17,
27
]
} |
and epiglottitis or supraglottitis , a disease that has been identified as most frequently due to a specific organism , h. influenzae . | NA | {
"id": "C0014541",
"name": "epiglottitis",
"pos": [
4,
16
]
} | {
"id": "C0749165",
"name": "supraglottitis",
"pos": [
20,
34
]
} |
in the presence of 50 microm 2',5'-dideoxyadenosine ( dda ) , a p-site agonist which inhibits the catalytic activity of adenylate cyclase , coronary flow increases induced by both adenosine and neca were unaffected . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
42,
51
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
194,
198
]
} |
data presented here shows that npy responsiveness is restored , in piroxicam pretreated tissues , by vasoactive intestinal polypeptide ( vip ) , forskolin , prostaglandin e2 ( pge2 ) isobutyl-1-methyl-xanthine ( ibmx ) and dibutyryl camp added prior to the neuropeptide . | NA | {
"id": "C0027893",
"name": "npy",
"pos": [
31,
34
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
257,
269
]
} |
benzaldehydes which do not carry an ionic negative charge are accepted by the pah-transporter , if they possess a second partially charged aldehyde or no2-group . | NA | {
"id": "C0005024",
"name": "benzaldehydes",
"pos": [
0,
13
]
} | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
139,
147
]
} |
the elevated nefa levels are in line with the notion that pyruvate competes with endogenously produced fatty acids for oxidative energy production . | NA | {
"id": "C0015688",
"name": "nefa",
"pos": [
13,
17
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
103,
114
]
} |
in nine patients with suspected psychogenic seizures and in three patients with proven epileptic seizures hmpao-spect was performed prior to and during seizure . | NA | {
"id": "C0014544",
"name": "epileptic seizures",
"pos": [
87,
105
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
152,
159
]
} |
patients with proven epilepsy revealed partly normal findings interictally but during seizure a markedly increased circumscript blood flow was found in all patients . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
21,
29
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
86,
93
]
} |
in the few isolated reports of carotenoid-related toxicity , the findings are associated with very large intakes of foods containing beta-carotene , among other constituents , and have not been substantiated in individuals who have taken high doses of beta-carotene for several years . | NA | {
"id": "C0007271",
"name": "carotenoid",
"pos": [
31,
41
]
} | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
252,
265
]
} |
based on the number of times they appeared as efficient discriminating variables at higher f values , alanine , proline , and isoleucine seemed to be the most important amino acids for correctly classifying shell membranes by egg type . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
102,
109
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
169,
180
]
} |
concentrations of corticotropin ( acth ) , prolactin , somatotropin ( sth ) , thyrotropin ( tsh ) , cortisol , aldosterone , adrenalin , noradrenaline , dopamine and blood renin activity were determined by radioimmunoassays and radioenzymatic methods on an empty stomach and 30 , 60 min. , 2 , 4 and 24 h after parlodel ... | NA | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
125,
134
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
137,
150
]
} |
changes in the secretion of catecholamines were of diverse nature : a decrease in the blood concentration of noradrenaline in the absence of adrenalin and dopamine shifts . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
109,
122
]
} | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
141,
150
]
} |
[ activity of serum and lymphocyte serine proteases of patients with diabetes mellitus and the possibility of using protease blockers in combined therapy ] . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
35,
51
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
116,
124
]
} |
the role of serine proteases of trypsin type was shown in the pathogenesis of autoimmune processes and nonspecific reactivity in diabetes mellitus . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
12,
28
]
} | {
"id": "C0041236",
"name": "trypsin",
"pos": [
32,
39
]
} |
control experiments indicate that the effect is best described as anterograde amnesia resulting from a failure of consolidation . gamma-aminobutyric acid ( gaba ) antagonists had almost no effect on benzodiazepine-induced amnesia , whereas the benzodiazepine-receptor antagonist ro 15-1788 completely and specifically re... | NA | {
"id": "C0233795",
"name": "anterograde amnesia",
"pos": [
66,
85
]
} | {
"id": "C0002622",
"name": "amnesia",
"pos": [
222,
229
]
} |
these oncogenes are implicated in the majority of cancers and in particular in bronchial carcinoma : the myc-oncogenes ( c-myc , n myc , l myc ) are primarily activated in small cell carcinomas ( cpc ) , the ras genes ( ki ras , ha ras ) in epidermoid and adeno carcinomas . | NA | {
"id": "C0262584",
"name": "small cell",
"pos": [
172,
182
]
} | {
"id": "C0007097",
"name": "carcinomas",
"pos": [
262,
272
]
} |
lymphoid proliferations in the acquired immunodeficiency syndrome reflect the profound immunologic imbalances induced by the lymphotropic human immunodeficiency virus , and comprise a range of lymphoproliferative disorders from benign lymphadenopathy to malignant lymphoma . | NA | {
"id": "C0024314",
"name": "lymphoproliferative disorders",
"pos": [
193,
222
]
} | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
264,
272
]
} |
in managing epilepsy , drugs that offer the best seizure control to the patient should be used , but their influence on quality of life must also be considered . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
12,
20
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
49,
56
]
} |
it is based on the use of highly specific sheep antiserum , 125i-labelled tracer , dextran-coated charcoal to separate the antibody bound and free fractions , and sodium salicylate to eliminate interference from endogenous binding proteins in serum . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
48,
57
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
123,
131
]
} |
the ascites to serum ratios for other proteins such as igg , iga and igm and also cholesterol and phospholipids were lower than that for albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
38,
46
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
137,
144
]
} |
concentrations of triiodothyronine ( t3 ) , thyroxine ( t4 ) , reflecting the thyroid status , and thyrotropin , a hormone of the anterior pituitary were investigated in 123 patients with exacerbation of chronic pancreatitis . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
99,
110
]
} | {
"id": "C0032016",
"name": "hormone",
"pos": [
115,
122
]
} |
it is concluded that thrombin and factor xa are taken up and inhibited by ec , smc and rhc cell surfaces in similar ratios , suggesting that cell surface-mediated inhibition of clotting factors is not restricted to vascular wall cells . | NA | {
"id": "C0040018",
"name": "thrombin",
"pos": [
21,
29
]
} | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
177,
193
]
} |
this concentration of the three lmw heparins increased , by approximately 70-fold , the rate of factor xa inhibition by purified antithrombin iii compared to the 50-fold increase seen with the two unfractionated heparins . | NA | {
"id": "C0019139",
"name": "lmw heparins",
"pos": [
32,
44
]
} | {
"id": "C0019134",
"name": "unfractionated heparins",
"pos": [
197,
220
]
} |
prothrombinase , constituted of purified factors xa , va and phospholipids was not inhibited by pps , neither were incomplete forms of this enzyme , lacking phospholipids or factor va . | NA | {
"id": "C0015518",
"name": "prothrombinase",
"pos": [
0,
14
]
} | {
"id": "C0015520",
"name": "factors xa",
"pos": [
41,
51
]
} |
plasma defibrinogenated dogs were used to study the influence of conventional heparin and a low molecular weight heparin fragment ( fragmin , mean mw 5,000 d ) on platelet dependent hemostasis . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
78,
85
]
} | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
92,
120
]
} |
inhibition in purified systems and in human plasma of chimaeric plasminogen activators consisting of the nh2-terminal region of tissue-type plasminogen activator and the cooh-terminal region of urokinase-type plasminogen activator . | NA | {
"id": "C0032144",
"name": "plasminogen",
"pos": [
64,
75
]
} | {
"id": "C0032143",
"name": "tissue-type plasminogen",
"pos": [
128,
151
]
} |
decreased platelet-free dopamine and unchanged platelet noradrenaline and adrenaline persisted after adjustment for increased body weight in the hypertensive group . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
56,
69
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
74,
84
]
} |
previous and recent reports have suggested a fibrinolysis-enhancing property of standard heparin and low molecular weight heparins , but these observations have never been confirmed in a study fulfilling appropriate methodological criteria . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
89,
96
]
} | {
"id": "C0019139",
"name": "low molecular weight heparins",
"pos": [
101,
130
]
} |
the aim of this study was to evaluate the effect of standard heparin and a low molecular weight heparin ( kabi 2165 ) on fibrinolysis in a randomized cross-over double blind placebo controlled study . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
61,
68
]
} | {
"id": "C0019139",
"name": "low",
"pos": [
75,
78
]
} |
standard heparin and kabi 2165 , 10,000 anti-xa u , produced a statistically significant increase in t-pa level at 1 hour after the infusion . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
9,
16
]
} | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
40,
47
]
} |
we conclude that an intravenous bolus dose of both standard heparin , 5,000 i.u . and kabi 2165 , 10,000 anti-xa u produces a delayed and sustained increase in plasma t-pa . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
60,
67
]
} | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
105,
112
]
} |
recurrent spontaneous abortions ( rsa ) of unknown etiology ( n = 105 ) and rsa - primary aborters only ( n = 84 ) ; | NA | {
"id": "C0000809",
"name": "rsa",
"pos": [
34,
37
]
} | {
"id": "C0000786",
"name": "rsa",
"pos": [
76,
79
]
} |
the results together with data from the literature suggest that the balance between p-450 isozymes and detoxifying enzymes differs in the nose compared with the liver . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
90,
98
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
115,
122
]
} |
deoxycorticosterone ( doc ) derivative compounds ( doc , doc 21-acetate , and 7-mercaptopropionic doc ) have been prepared and purified by high pressure liquid chromatography . | NA | {
"id": "C0813203",
"name": "doc 21-acetate",
"pos": [
57,
71
]
} | {
"id": "C0011710",
"name": "doc",
"pos": [
98,
101
]
} |
also discussed are the mechanism of action , spectrum of activity , toxicity , disposition , and drug interactions of various antimicrobial agents , including the aminoglycosides , beta-lactam antibiotics , quinolones , tetracyclines , chloramphenicol , and the polymyxins . | NA | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
126,
146
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
163,
178
]
} |
glucose , fructose , sucrose , galactose , trehalose , n-acetyl-glucosamine , glucosamine , mannose , maltose and pyruvate were growth substrates for all 3 strains . | NA | {
"id": "C0001056",
"name": "n-acetyl-glucosamine",
"pos": [
55,
75
]
} | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
78,
89
]
} |
the epitopes on the hexon molecule could be separated into three antigenic sites , of which one antigenic site is characterized by seven epitope clusters ( antigenic site ii ) . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
4,
11
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
156,
165
]
} |
the lack of reactivity of the antibody with fdps makes it a suitable reagent for investigating plasmin activity as well as studying fibrinogen and fibrin . | NA | {
"id": "C0163275",
"name": "fdps",
"pos": [
44,
48
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
147,
153
]
} |
in v79 chinese hamster cells , c3h/10t1/2 mouse embryo fibroblasts , and diploid human foreskin fibroblasts , crude borax ore , kernite ore , and refined borax were all cytotoxic . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
23,
28
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
96,
107
]
} |
the concentrations of borax ore , kernite ore , and refined borax that reduced the relative plating efficiency to 50 % were approximately 3.2 , 1.6 , and 0.8 mg/ml , respectively , in human fibroblasts and were 0.8 mg/ml for all three substances in c3h/10t1/2 cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
190,
201
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
260,
265
]
} |
all three borax samples were not significantly mutagenic in assays for mutation to ouabain resistance in human fibroblasts an c3h/10t1/2 cells and were at most only weakly mutagenic in an assay for mutation to 8-azaguanine resistance in v79 chinese hamster cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
111,
122
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
257,
262
]
} |
admixtures of amikacin 2 mg/ml , gentamicin 1.6 mg/ml , kanamycin 2 mg/ml , netilmicin 1.5 mg/ml , and tobramycin 1.6 mg/ml ( as the sulfate salts ) were prepared in both 5 % dextrose injection and 0.9 % sodium chloride injection in minibags . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
14,
22
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
56,
65
]
} |
the association of pernicious anemia , an autoimmune disease , with other immunologic disorders such as dermatitis herpetiformis , hashimoto 's thyroiditis , hypothyroidism , hyperthyroidism , vitiligo , adrenal insufficiency , adult-onset immunoglobulin deficiency , hypoparathyroidism , and possibly diabetes mellitus ... | NA | {
"id": "C0004364",
"name": "autoimmune disease",
"pos": [
42,
60
]
} | {
"id": "C0011608",
"name": "dermatitis herpetiformis",
"pos": [
104,
128
]
} |
the association of pernicious anemia with giant cell myocarditis , a rare fatal illness believed by some to represent an autoimmune abnormality occurring with other autoimmune diseases such as thymoma , systemic lupus erythematosus , dermatomyositis , thyrotoxicosis , wegener 's granulomatosis , and sjogren 's syndrome... | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
165,
184
]
} | {
"id": "C0024141",
"name": "systemic",
"pos": [
203,
211
]
} |
aztreonam demonstrated very little ability to interact with anti-penicillin or anti-cephalothin antibodies as it required 10,000-fold higher concentrations than other beta-lactams to achieve equivalent blocking . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
65,
75
]
} | {
"id": "C0282215",
"name": "beta-lactams",
"pos": [
167,
179
]
} |
the focus of monobactam development then turned toward increasing the binding activity of the beta-lactam ring of the molecule . | NA | {
"id": "C0026458",
"name": "monobactam",
"pos": [
13,
23
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
94,
105
]
} |
aztreonam , a new monobactam antibiotic with specific gram-negative aerobic activity , was used in combination with clindamycin in the treatment of 40 women with pelvic infection , including post-partum endometritis , pelvic inflammatory disease , and post-hysterectomy pelvic cellulitis . | NA | {
"id": "C0242172",
"name": "pelvic inflammatory",
"pos": [
218,
237
]
} | {
"id": "C0030455",
"name": "pelvic cellulitis",
"pos": [
270,
287
]
} |
duplication of hands and feet , multiple joint dislocations , absence of corpus callosum and hypsarrhythmia : acrocallosal syndrome ? | NA | {
"id": "C0175754",
"name": "absence of corpus",
"pos": [
62,
79
]
} | {
"id": "C0796147",
"name": "acrocallosal syndrome",
"pos": [
110,
131
]
} |
all patients showed increased concentrations of adenosine 5'-diphosphate ( adp ) and adenosine 5'-monophosphate ( amp ) , while adenosine 5'-triphosphate ( atp ) , nicotinamide adenine dinucleotide ( nad+ ) and nicotinamide adenine dinucleotide phosphate ( nadp+ ) were within normal ranges . | NA | {
"id": "C0001459",
"name": "adenosine 5",
"pos": [
48,
59
]
} | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
128,
139
]
} |
all patients showed increased concentrations of adenosine 5'-diphosphate ( adp ) and adenosine 5'-monophosphate ( amp ) , while adenosine 5'-triphosphate ( atp ) , nicotinamide adenine dinucleotide ( nad+ ) and nicotinamide adenine dinucleotide phosphate ( nadp+ ) were within normal ranges . | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
48,
59
]
} | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
128,
139
]
} |
all patients showed increased concentrations of adenosine 5'-diphosphate ( adp ) and adenosine 5'-monophosphate ( amp ) , while adenosine 5'-triphosphate ( atp ) , nicotinamide adenine dinucleotide ( nad+ ) and nicotinamide adenine dinucleotide phosphate ( nadp+ ) were within normal ranges . | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
48,
59
]
} | {
"id": "C0027270",
"name": "nad",
"pos": [
257,
260
]
} |
all patients showed increased concentrations of adenosine 5'-diphosphate ( adp ) and adenosine 5'-monophosphate ( amp ) , while adenosine 5'-triphosphate ( atp ) , nicotinamide adenine dinucleotide ( nad+ ) and nicotinamide adenine dinucleotide phosphate ( nadp+ ) were within normal ranges . | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
48,
59
]
} | {
"id": "C0027303",
"name": "nadp",
"pos": [
257,
261
]
} |
the disopyramide-free fraction varied more than tenfold at a corresponding total ( free plus bound ) serum disopyramide concentration of 3 micrograms/ml and was related to the concentration of an acute-phase protein , alpha-1-acid glycoprotein ( aag ) , in patient serum . | NA | {
"id": "C0001347",
"name": "acute-phase protein",
"pos": [
196,
215
]
} | {
"id": "C0029297",
"name": "alpha-1-acid glycoprotein",
"pos": [
218,
243
]
} |
amide-linked local anesthetic agents , such as lidocaine and bupivacaine , can become `` '' trapped '' '' in their ionized forms on the fetal side of the placenta , and therefore their net transfer across the placenta is increased . | NA | {
"id": "C2917349",
"name": "amide",
"pos": [
0,
5
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
47,
56
]
} |
amide-linked local anesthetic agents , such as lidocaine and bupivacaine , can become `` '' trapped '' '' in their ionized forms on the fetal side of the placenta , and therefore their net transfer across the placenta is increased . | NA | {
"id": "C2917349",
"name": "amide",
"pos": [
0,
5
]
} | {
"id": "C0006400",
"name": "bupivacaine",
"pos": [
61,
72
]
} |
the approximate rank order of prostaglandin release into the maternal side was thromboxane b2 greater than prostaglandin f2 alpha congruent to prostaglandin e congruent to 6-oxo-prostaglandin f1 alpha , and that into the fetal side was thromboxane b2 congruent to prostaglandin f2 alpha congruent to prostaglandin e cong... | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
30,
43
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
300,
315
]
} |
it is proposed that prostaglandin release into both maternal and fetal circulations may be flow-dependent and that the angiotensin ii-stimulated release of prostaglandin e and 6-oxo-prostaglandin f1 alpha may serve to modulate the vasoactive actions of angiotensin ii on the fetal vasculature . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
20,
33
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
156,
171
]
} |
mnng treatments of this hepatic epithelial cell population resulted in a progressively increasing phenotypic alteration and heterogeneity including changes in specific activities of several cellular enzymes and expression of isozymes , synthetic functions , and various in vitro growth properties . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
199,
206
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
225,
233
]
} |
in principle , it should be possible to prepare monoclonal antibodies against these cell-specific antigens and to use the antibodies as immunoaffinity reagents to isolate populations of specific renal cell types . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
48,
69
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
122,
132
]
} |
these studies confirm a modest role for alpha-adrenoreceptors in the high rvr characteristic of newborn pups and provide evidence for a role of alpha 2-adrenoceptors in the renal transport of sodium ; | NA | {
"id": "C0034784",
"name": "alpha-adrenoreceptors",
"pos": [
40,
61
]
} | {
"id": "C0001639",
"name": "alpha 2-adrenoceptors",
"pos": [
144,
165
]
} |
two groups of animals were used for the correlative physiological-morphological studies : normal protein ( np , 24 % dietary protein ) rats and reduced protein ( lp , 8 % dietary protein ) rats . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
97,
104
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
171,
186
]
} |
the sympathetic adrenergic neurotransmitter norepinephrine and the neurohormone epinephrine also inhibit the overflow of [ 3h ] acetylcholine by approximately 60 % . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
44,
58
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
80,
91
]
} |
native sarcolemma ( sl ) from adult canine cardiac myocytes ( na+-k+-atpase activity 74.2 +/- 3.0 mumol x mg-1 x h-1 ) was preincubated ( 10 min , 37 degrees c , ph 7.2 ) with 1 ) 20-600 microm palmitoyl carnitine , 2 ) 250 nm-2.5 mm propranolol , or 3 ) 20-600 microm palmitoyl carnitine plus propranolol at various con... | NA | {
"id": "C0030242",
"name": "palmitoyl carnitine",
"pos": [
194,
213
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
279,
288
]
} |
we correlated levels of circulating norepinephrine ( ne ) and epinephrine ( epi ) induced by 1 ) infusions , 2 ) treadmill exercise , and 3 ) hemorrhage with left ventricular ( lv ) function in conscious dogs instrumented for the measurement of lv and arterial pressures , lv diameter , and calculations of indexes of my... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
36,
50
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
62,
73
]
} |
moderate treadmill exercise doubled lv dp/dt , while ne and epi rose by only 563 +/- 128 and 292 +/- 50 pg/ml , respectively . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
53,
55
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
60,
63
]
} |
hemorrhage ( 30 ml/kg ) decreased all indexes of contractility but increased plasma ne by 1,108 +/- 206 pg/ml and epi by 1,475 +/- 266 pg/ml . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
84,
86
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
114,
117
]
} |
infusions of ne or epi to equal the plasma levels during exercise increased contractility by only 5-10 % . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
13,
15
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
19,
22
]
} |
likewise a linear correlation between the renal and extra-renal excretion of 45ca could be demonstrated with a ratio of 1:0.47 , indicating that the renal route of excretion is of major importance in this species . | NA | {
"id": "C1373187",
"name": "renal excretion",
"pos": [
58,
73
]
} | {
"id": "C1373186",
"name": "route of excretion",
"pos": [
155,
173
]
} |
the changes in gsh secretion induced by these dyes were accompanied by proportional changes in glutathione disulfide ( gssg ) secretion into bile , so that the molar ratio of gssg to gsh in bile remained within the range of 0.07-0.18 . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
119,
123
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
183,
186
]
} |
the results suggest that the bsp-induced inhibition of gsh , gssg , and methylmercury secretion into bile is due to the direct inhibition of the biliary gsh transport process . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
55,
58
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
61,
65
]
} |
to assess a role for peripherally administered angiotensin ii ( ang ii ) in regulating vasopressin ( antidiuretic hormone , adh ) release , the effects on plasma ang ii and adh of intraperitoneal injections of ang ii dissolved in various solutions were examined in conscious rats . | NA | {
"id": "C0003779",
"name": "vasopressin",
"pos": [
87,
98
]
} | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
101,
121
]
} |
norepinephrine and epinephrine were measured serially in 24-hour urine collections from 99 male psychiatric inpatients with mixed diagnoses . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
19,
30
]
} |
we report the immunohistochemical and ultrastructural features of three duodenal gangliocytic paragangliomas and compare them with duodenal carcinoid , extra-adrenal paraganglioma , pheochromocytoma , and ganglioneuroma . | NA | {
"id": "C0030421",
"name": "gangliocytic paragangliomas",
"pos": [
81,
108
]
} | {
"id": "C0031511",
"name": "pheochromocytoma",
"pos": [
182,
198
]
} |
the case is presented to illustrate firstly how hyperthyroidism may be masked by other acute illnesses , and secondly an unusual complication of thyrotoxicosis . | NA | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
48,
63
]
} | {
"id": "C0040156",
"name": "thyrotoxicosis",
"pos": [
145,
159
]
} |
we describe a seven-compartment physiologic model of inhalational anesthetic induction with circulatory shunts that was used to simulate inhalational anesthetic induction in children with congenital heart disease . | NA | {
"id": "C0242903",
"name": "inhalational anesthetic",
"pos": [
53,
76
]
} | {
"id": "C0002932",
"name": "anesthetic",
"pos": [
150,
160
]
} |
the infusion of saralasin , an angiotensin ii antagonist , resulted in a further decrease in blood pressure in shr anesthetized with halothane but not with enflurane . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
16,
25
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
31,
45
]
} |
the effects of fentanyl and sufentanil with and without n2o on left ventricular myocardium supplied by a critically narrowed and a normal coronary artery were studied in 16 dogs . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
15,
23
]
} | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
28,
38
]
} |
eight dogs received fentanyl 100 micrograms x kg-1 followed by an infusion of 1 microgram x kg-1 x min-1 while ventilated with o2 : n2 ( 1:2 ) , and eight dogs received sufentanil 30 micrograms x kg-1 with an infusion of 0.3 micrograms x kg-1 x min-1 . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
20,
28
]
} | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
169,
179
]
} |
higher infusion rates of either narcotic ( fentanyl 2 micrograms x kg-1 x min-1 , 4 micrograms x kg-1 x min-1 ; sufentanil 0.6 micrograms x kg-1 x min-1 , 1.2 micrograms x kg-1 x min-1 ) in the absence of n2o did not produce dysfunction but had no protective effect when n2o was added . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
43,
51
]
} | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
112,
122
]
} |
caprine b lymphocytes were established as the cell type that divided when cultured with lipopolysaccharide ( lps ) , and lipid a was defined as the in vitro mitogenic component of lps . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
121,
128
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
180,
183
]
} |
the lipid a subunit of lps was most likely responsible for mitogenesis , since purified lipid a stimulated lymphocytes and the addition of polymyxin b , a specific inhibitor of lipid a activity , blocked the lymphocyte reaction . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
23,
26
]
} | {
"id": "C0023767",
"name": "a",
"pos": [
221,
222
]
} |
in this study , we examined the relationship between contraction and release of histamine and slow-reacting substance of anaphylaxis ( leukotrienes ) in superfused trachea and parenchymal strips as well as mediator release from minced lung fragments after passive sensitization of guinea pigs with igg1 or ige antibodies... | NA | {
"id": "C0038091",
"name": "slow-reacting substance of anaphylaxis",
"pos": [
94,
132
]
} | {
"id": "C0023545",
"name": "leukotrienes",
"pos": [
135,
147
]
} |
all patients presenting with pulsatile hemorrhage , expanding hematoma , or absent distal pulses were explored immediately . | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
39,
49
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
62,
70
]
} |
these data suggest that persistent generalized lymphadenopathy and the acquired immunodeficiency syndrome are part of a clinical spectrum of htlv-iii infection and that most high-risk homosexual men in some regions of the united states have not yet been infected with this virus . | NA | {
"id": "C0001175",
"name": "acquired immunodeficiency",
"pos": [
71,
96
]
} | {
"id": "C0019693",
"name": "htlv-iii infection",
"pos": [
141,
159
]
} |
unusual manifestations of tumors , such as the massive gastrointestinal bleeding seen in this case , may indicate the development of a second neoplasm . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
26,
32
]
} | {
"id": "C0085183",
"name": "second neoplasm",
"pos": [
135,
150
]
} |
using long-acting ovine crf ( 1 microgram/kg body weight as an intravenous bolus ) , we tested patients with cushing 's syndrome , adrenal insufficiency , and psychiatric conditions with mild hypercortisolism . | NA | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
109,
128
]
} | {
"id": "C0001622",
"name": "hypercortisolism",
"pos": [
192,
208
]
} |
the responses in the psychiatric patients should permit differentiation between cushing 's syndrome and hypercortisolism of psychiatric origin . | NA | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
80,
99
]
} | {
"id": "C0001622",
"name": "hypercortisolism",
"pos": [
104,
120
]
} |
acarid mites use terpenoids as alarm pheromones and allomones , while certain phytoseiid and tetranychnid mites use terpene alcohols as arrestant sex pheromones . | NA | {
"id": "C0031516",
"name": "pheromones",
"pos": [
37,
47
]
} | {
"id": "C0036863",
"name": "sex pheromones",
"pos": [
146,
160
]
} |
thus , two separate sex pheromones are necessary to successfully complete courtship in certain dermacentor ticks , while three pheromones appear necessary to complete feeding-site selection , attachment , and clasping in certain amblyomma species . | NA | {
"id": "C0036863",
"name": "sex pheromones",
"pos": [
20,
34
]
} | {
"id": "C0031516",
"name": "pheromones",
"pos": [
127,
137
]
} |
the labeling pattern of the product derived from [ 1-3h2 , u-14c ] geranyl pyrophosphate was determined by oxidation of the biosynthetic borneol to camphor and selective removal of tritium by exchange of the alpha hydrogens at c3 of the ketone . | NA | {
"id": "C0041119",
"name": "tritium",
"pos": [
181,
188
]
} | {
"id": "C0020275",
"name": "hydrogens",
"pos": [
214,
223
]
} |
comparison of the amounts of creatine synthesized with the amounts taken up showed that synthesis can make a significant contribution to intracellular pools of creatine plus phosphocreatine in fibroblasts and neuroblastoma cells . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
29,
37
]
} | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
174,
189
]
} |
hsv glycoprotein gc was the predominant cell-surface glycoprotein radiolabeled by the galactose oxidase/nab3h4 method in virus-infected bhk-21 cells . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
4,
16
]
} | {
"id": "C0025248",
"name": "cell-surface glycoprotein",
"pos": [
40,
65
]
} |
interfibrillar mitochondria oxidized substrates donating reducing equivalents at complex i ( nadh-coq reductase ) , complex ii ( succinate-coq reductase ) , and complex iii ( coqh2-cytochrome c reductase ) more rapidly than did subsarcolemmal mitochondria . | NA | {
"id": "C0283592",
"name": "complex ii",
"pos": [
116,
126
]
} | {
"id": "C0038615",
"name": "succinate",
"pos": [
129,
138
]
} |
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