text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the higher fluorescence quenching in the presence of substrates of pyruvate dehydrogenase complex compared to the effect caused by the substrates of the e3 component ( dihydrolipoic acid and dte ) indicates conformational changes additionally manifested in the fluorescence properties of the enzyme complex . | NA | {
"id": "C0034344",
"name": "pyruvate dehydrogenase complex",
"pos": [
67,
97
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
292,
298
]
} |
phosphorylase was a competitive substrate in the hmg-coa reductase phosphatase and glycogen synthase phosphatase reactions of protein phosphatases i1 , i3 , and ii . | NA | {
"id": "C0017933",
"name": "glycogen",
"pos": [
83,
91
]
} | {
"id": "C0031686",
"name": "protein phosphatases",
"pos": [
126,
146
]
} |
a model is presented which is consistent with the hysteretic inhibition of f1 by azide , in which there is a slow equilibration between free enzyme and the enzyme-magnesium-azide complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
141,
147
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
156,
162
]
} |
it did not inhibit the other chymotrypsin-type serine endopeptidases tested , trypsin , papain , collagenase , carboxypeptidase a , or cathepsin d . | NA | {
"id": "C0008742",
"name": "chymotrypsin",
"pos": [
29,
41
]
} | {
"id": "C0036734",
"name": "serine endopeptidases",
"pos": [
47,
68
]
} |
it did not inhibit the other chymotrypsin-type serine endopeptidases tested , trypsin , papain , collagenase , carboxypeptidase a , or cathepsin d . | NA | {
"id": "C0036734",
"name": "serine endopeptidases",
"pos": [
47,
68
]
} | {
"id": "C0041236",
"name": "trypsin",
"pos": [
78,
85
]
} |
coelectrophoresis of purified oligosaccharides has established that adjacent bands differ in chain length by one disaccharide unit . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
30,
46
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
113,
125
]
} |
of particular interest was the identification of the magnesium-stimulated atpase ( mg-atpase ) , which is characteristically located in native isolated tt vesicles of chicken skeletal muscle [ r. a. sabbadini and v. r. okamoto ( 1983 ) arch . biochem . biophys . 223 , 107-119 ] . | NA | {
"id": "C0001477",
"name": "magnesium",
"pos": [
53,
62
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
86,
92
]
} |
uft ( 3 capsules ; 300mg ft ) was administered to five of 10 patients with renal cell carcinoma , and concentrations of ft , 5-fu and uracil in the serum and tissues ( normal renal tissues , renal tumor tissues and liver ) were determined 5.2 hours on average , after administration . | NA | {
"id": "C0016360",
"name": "5-fu",
"pos": [
125,
129
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
134,
140
]
} |
there was a positive correlation between the concentration of 5-fu in the tissues and the concentration of uracil in the tissues . | NA | {
"id": "C0016360",
"name": "fu",
"pos": [
64,
66
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
107,
113
]
} |
'79 to sept. 30 ' 80 ) of lentinan in combination administration with chemotherapeutic agents such as 5fu + mitomycin c or tegafur on patients with advanced or recurrent gastrointestinal cancer has shown that lentinan has been effective in such cases with regard to the following facts : 1 ) a life span prolongation eff... | NA | {
"id": "C0016360",
"name": "5fu",
"pos": [
102,
105
]
} | {
"id": "C0016778",
"name": "tegafur",
"pos": [
123,
130
]
} |
three died before the correct diagnosis of disordered sympathetic innervation of the heart was made , but episodes of syncope and cardiac arrhythmias in the survivors have been successfully treated by propranolol . | NA | {
"id": "C0018799",
"name": "the",
"pos": [
18,
21
]
} | {
"id": "C0003811",
"name": "cardiac arrhythmias",
"pos": [
130,
149
]
} |
twenty-six patients with xeroderma pigmentosum ( xp ) , who live in the northeast ( tohoku ) district of japan , were examined for the clinical characteristics of uv-induced dna synthesis ( unscheduled dna synthesis , uds ) and uv sensitivity of skin fibroblasts or lymphoblastoid cells , or both . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
251,
262
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
281,
286
]
} |
the total protein synthesized was determined by the incorporation of radioactive proline , and the collagenous protein synthesized was measured by the incorporation of labeled hydroxyproline in the cell layer and medium . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
81,
88
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
176,
190
]
} |
normal keratinocytes and tumor cells from other diseases such as mammary paget 's disease , malignant melanoma , squamous cell carcinoma , basal cell epithelioma , bowen 's disease , and seborrheic keratosis were positively stained with con a , wga , and rca-i , but not with dba except in some of the mammary paget 's c... | NA | {
"id": "C0007137",
"name": "squamous cell carcinoma",
"pos": [
113,
136
]
} | {
"id": "C0006079",
"name": "bowen 's disease",
"pos": [
164,
180
]
} |
although an association between head and neck irradiation and primary hyperparathyroidism is known , we believe this to be the first report of recurrent hyperparathyroidism in an irradiated patient . | NA | {
"id": "C0221002",
"name": "primary hyperparathyroidism",
"pos": [
62,
89
]
} | {
"id": "C0020502",
"name": "hyperparathyroidism",
"pos": [
153,
172
]
} |
five impotent men underwent internal iliac artery revascularization in conjunction with end-to-side aortobifemoral bypass after preoperative testing suggested a vasculogenic cause for impotence . | NA | {
"id": "C0242350",
"name": "impotent",
"pos": [
5,
13
]
} | {
"id": "C0243000",
"name": "vasculogenic",
"pos": [
161,
173
]
} |
rat cytomegalovirus induces cellular purine and pyrimidine nucleoside kinases in rat embryo fibroblasts and tk- rat-2 cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
92,
103
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
118,
123
]
} |
a deoxycytidine kinase ( dck ) is induced in either growing or rcmv-infected ref and r-2 cells , suggesting that dck is essential for both host-cell and viral dna synthesis . | NA | {
"id": "C0016030",
"name": "ref",
"pos": [
77,
80
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
89,
94
]
} |
a deoxyguanosine kinase ( dgk ) is detectable in low concentrations in either growing or g0-phase ref and r-2 cells suggesting that this enzyme is cell-cycle independent . | NA | {
"id": "C0016030",
"name": "ref",
"pos": [
98,
101
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
110,
115
]
} |
we have compared the kinetic growth patterns of to-336 , meq11 , krt , and sk2 rubella vaccine strains licensed in japan at 37 degrees and 39 degrees c with those of progenitor wild strains of rubella virus . | NA | {
"id": "C0035923",
"name": "rubella vaccine",
"pos": [
79,
94
]
} | {
"id": "C0035924",
"name": "rubella virus",
"pos": [
193,
206
]
} |
in addition epitope variations were found in both np and p protein , which contrasted with conserved antigen characteristics of these components in lytically replicating virus . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
12,
19
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
101,
108
]
} |
herpes simplex virus ( hsv ) hyperresistant neuroblastoma cells ( clone cl300 rii ) were latently infected with hsv-1 if cultured in presence of hsv-neutralizing antibody for one or two passages after infection and then passaged further without antibody . | NA | {
"id": "C0475463",
"name": "neutralizing",
"pos": [
149,
161
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
245,
253
]
} |
it is suggested that polyphosphoinositides are under stringent and complex control and that upon receptor activation-mediated stimulation of phosphodiesteratic degradation release of the feedback inhibition shown here may occur and result in the synthesis and replenishment of pip2 . | NA | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
21,
42
]
} | {
"id": "C0070798",
"name": "pip2",
"pos": [
277,
281
]
} |
we further demonstrate that the pma effect is also associated with a dramatic phosphorylation of hla antigens in hl-60 leukemic cells and in human lymphocytes , showing that an increase in phosphorylation of hla antigens is intimately related to the signal of pma in various cellular systems . | NA | {
"id": "C0019728",
"name": "a",
"pos": [
19,
20
]
} | {
"id": "C0019721",
"name": "hla antigens",
"pos": [
208,
220
]
} |
the antilymphocytic and antiphlogistic agent cyclosporin a ( csa ) inhibits in vivo various effects induced by the tumor promoting phorbol ester 12-0-tetradecanoylphorbol-13-acetate ( tpa ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
131,
144
]
} | {
"id": "C0039654",
"name": "tetradecanoylphorbol",
"pos": [
150,
170
]
} |
monoclonal antibodies to enkephalins were established by immunization of mice with met-enkephalin , leu-enkephalin or both . | NA | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
25,
36
]
} | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
83,
97
]
} |
monoclonal antibodies to enkephalins were established by immunization of mice with met-enkephalin , leu-enkephalin or both . | NA | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
25,
36
]
} | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
100,
114
]
} |
canine carbonic anhydrase shows similar results to human carbonic anhydrase i , retaining 29 % hydratase and 62 % esterase activity . | NA | {
"id": "C0007028",
"name": "carbonic anhydrase",
"pos": [
7,
25
]
} | {
"id": "C0007033",
"name": "carbonic anhydrase i",
"pos": [
57,
77
]
} |
of the three proteins , only f-actin would directly interact with a membrane preparation that had been extensively washed to remove associated cytoskeletal proteins . alpha-actinin would only add to the membrane to which f-actin had been re-attached and abp only if both f-actin and alpha-actinin were present on the mem... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
13,
21
]
} | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
143,
164
]
} |
through the use of apolipoprotein-phospholipid complexes , apolipoprotein e ( apoe ) was identified as the ligand mediating recognition of n-vldl by this receptor . | NA | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
19,
33
]
} | {
"id": "C0003595",
"name": "apolipoprotein e",
"pos": [
59,
75
]
} |
after this treatment gpp ( nh ) p had no effect on muscarinic receptor affinity and gtp stimulated basal adenylate cyclase activity . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
21,
33
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
84,
87
]
} |
an induced aldehyde dehydrogenase is active with several aliphatic and aromatic aldehydes but not with formaldehyde and glyceraldehyde . | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
80,
89
]
} | {
"id": "C0017854",
"name": "glyceraldehyde",
"pos": [
120,
134
]
} |
excretion , covalent binding and metabolism of hexachloro-1,3-butadiene ( hcbd ) , a nephrotoxic and nephrocarcinogenic compound , have been studied in female rats . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
0,
9
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
33,
43
]
} |
the following autoantibodies were sought : thyroid , gastric parietal cells , smooth muscle , striated muscle , microsomes , mitochondria , dna , extractable nuclear antigen , sm , pm-1 , antinuclear antibody ( ana ) , and rheumatoid factor . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
14,
28
]
} | {
"id": "C0003243",
"name": "antinuclear antibody",
"pos": [
188,
208
]
} |
the following autoantibodies were sought : thyroid , gastric parietal cells , smooth muscle , striated muscle , microsomes , mitochondria , dna , extractable nuclear antigen , sm , pm-1 , antinuclear antibody ( ana ) , and rheumatoid factor . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
14,
28
]
} | {
"id": "C0035448",
"name": "rheumatoid factor",
"pos": [
223,
240
]
} |
we examined 36 sera from patients with systemic lupus erythematosus , rheumatoid arthritis , sjogren 's syndrome , and drug-induced lupus erythematosus , who had positive clif tests . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
70,
90
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
93,
112
]
} |
in an in vitro model of fibroblast-lymphocyte interactions , we show that the supernatants of activated mononuclear cells ( mnc ) modulate gag synthesis , as measured by the incorporation of 3h-glucosamine into gag following incubation of the confluent fibroblast monolayers with active supernatant preparations . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
74,
77
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
253,
263
]
} |
an external cardiac pacemaker was used as part of initial resuscitative efforts for patients in primary , out-of-hospital , cardiac arrest who arrived in the emergency department in asystole , agonal rhythm , pulseless idioventricular rhythm , or bradycardia with hemodynamic compromise . | NA | {
"id": "C2936490",
"name": "out-of-hospital",
"pos": [
106,
121
]
} | {
"id": "C0018790",
"name": "asystole",
"pos": [
182,
190
]
} |
four patients with myocardial dysfunction related to tachycardia underwent electrophysiological studies , which showed a re-entrant supraventricular tachycardia using an accessory atrioventricular connexion . | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
53,
64
]
} | {
"id": "C0039240",
"name": "supraventricular",
"pos": [
132,
148
]
} |
the distribution and localization of nca and carcinoembryonic antigen cea in cells of different types of myelogenous leukaemias ( acute myelogenous leukaemia - aml ; chronic granulocytic leukaemia - cgl ; cgl in myeloblastic crisis - cgl-bc ) was studied using the immunofluorescence test . | NA | {
"id": "C0023470",
"name": "myelogenous leukaemias",
"pos": [
105,
127
]
} | {
"id": "C0023473",
"name": "cgl",
"pos": [
234,
237
]
} |
rabbits fed atherogenic diet developed hypercholesterolaemia ( means 733 mg/dl at 16 months ) and plasma lipoprotein ( lp ) distribution shifted from a pattern in which high-density lipoproteins ( hdl ) predominated to one in which very-low-density lipoproteins ( vldl ) were predominant . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
105,
116
]
} | {
"id": "C0023825",
"name": "very-low-density lipoproteins",
"pos": [
232,
261
]
} |
recently , a number of low molecular weight heparins have been prepared which have been shown to produce less bleeding than standard heparin for an equivalent antithrombotic effect in experimental animals . | NA | {
"id": "C0019139",
"name": "low molecular weight heparins",
"pos": [
23,
52
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
133,
140
]
} |
to determine this , we examined the pharmacokinetics of 125i-labelled standard heparin and a low molecular weight heparin , and their anticoagulant effects in mother and fetus , using a pregnant sheep model . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
79,
86
]
} | {
"id": "C0019139",
"name": "low",
"pos": [
93,
96
]
} |
anticardiolipin antibody levels were determined in 116 patients with systemic lupus erythematosus and related autoimmune disorders . | NA | {
"id": "C0024141",
"name": "systemic",
"pos": [
69,
77
]
} | {
"id": "C0004364",
"name": "autoimmune disorders",
"pos": [
110,
130
]
} |
it is also conceivable that the presence of anticardiolipin antibodies may select a subpopulation of patients with chronic aitp who may go on to develop other autoimmune disorders , such as systemic lupus erythematosus . | NA | {
"id": "C0004364",
"name": "autoimmune disorders",
"pos": [
159,
179
]
} | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
190,
218
]
} |
phylogenetically more conservative epitopes among monoclonal antibody-defined antigenic sites of human transferrin are involved in receptor binding . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
35,
43
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
78,
87
]
} |
in the present report , the aggregation response to a variety of inducers of platelet aggregation , the content of the dense granule constituents atp , adp , serotonin and calcium , the secretion of atp , adp , and calcium induced by thrombin , the total content of magnesium , the incorporation of 14c-adenine in the cy... | NA | {
"id": "C0001413",
"name": "adenine",
"pos": [
303,
310
]
} | {
"id": "C0001455",
"name": "cyclic-amp",
"pos": [
400,
410
]
} |
the levels of coagulation accelerating factor , fviii and von willebrand factor ( vwf ) were reduced by incubation with rabbit anti-human fviii/vwf or human anti-fviii serum indicating a close association of these three activities . | NA | {
"id": "C0005789",
"name": "coagulation",
"pos": [
14,
25
]
} | {
"id": "C0042971",
"name": "fviii/vwf",
"pos": [
138,
147
]
} |
it is suggested that the coagulation accelerating factor represents an active form of fviii which has different in vitro properties to thrombin activated fviii . | NA | {
"id": "C0005789",
"name": "coagulation",
"pos": [
25,
36
]
} | {
"id": "C0040018",
"name": "thrombin",
"pos": [
135,
143
]
} |
we further find specific cation effects , particularly on a 1-2 ns decay component at the fmax fluorescence level , that are proposed to be related to the effectiveness of electrostatic screening as determined by the hydrated metal ionic radius . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
25,
31
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
232,
237
]
} |
[ 3h ] prostaglandin e1 bound to the membrane preparation could not be displaced by gtp or by its stable derivative gpp [ nh ] p . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
84,
87
]
} | {
"id": "C0018366",
"name": "gpp [ nh ] p",
"pos": [
116,
128
]
} |
of all anions tested , including more permeant ( scn- and no3- ) or less permeant ( so4 ( 2- ) ) , chloride supported taurine accumulation to a significantly greater degree . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
7,
13
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
99,
107
]
} |
a second dipeptide l-carnosine ( beta-alanyl-l-histidine ) which is poorly hydrolysed by enterocytes also had no effect upon sodium efflux . | NA | {
"id": "C0012512",
"name": "dipeptide",
"pos": [
9,
18
]
} | {
"id": "C0007267",
"name": "carnosine",
"pos": [
21,
30
]
} |
displacement studies using angiotensin and various analogs of angiotensin ii disclosed a structure-activity profile similar to that found in physiologically relevant angiotensin ii receptor sites . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
27,
38
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
166,
180
]
} |
removal of the cytoskeletal proteins spectrin and actin by low ionic strength treatment or of all extrinsic proteins by alkali treatment of ghosts reduces the immobilized fraction to approx . | NA | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
15,
36
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
108,
116
]
} |
the addition of ca2+ to the electrolyte induces a lipid phase separation within the membrane into two fluid phases of distinctly different characteristics of the translocation of hydrophobic ions . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
28,
39
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
191,
195
]
} |
using the nondenaturing elution and alkaline elution techniques to examine fibroblasts from down syndrome patients and from controls , no specific abnormalities in down syndrome cells could be detected after exposure to mitotic inhibitors , including rate and extent of elution of dna from filters as well as repair of r... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
75,
86
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
178,
183
]
} |
at 0.75 mm mgcl2 , the pattern of chromatin fragmentation by dnaase i is similar to that generated by dnaase ii , and it is further changed at lower concentrations of magnesium . | NA | {
"id": "C0024472",
"name": "mgcl2",
"pos": [
11,
16
]
} | {
"id": "C0024467",
"name": "magnesium",
"pos": [
167,
176
]
} |
the ability of peptides to bind h2b antibodies was measured in an enzyme-linked immunosorbent assay , using antisera directed against calf thymus and chicken erythrocyte h2b as well as four anti h2b monoclonal antibodies obtained from autoimmune mice . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
36,
46
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
108,
116
]
} |
among some amino acids tested , l-alanine proved to be the most efficient amino donor , and the enzyme was also stereospecific for the l-isomer . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
11,
22
]
} | {
"id": "C0001898",
"name": "l-alanine",
"pos": [
32,
41
]
} |
the quenched fluorescence is consistent with stacking of the sulfonylbenzoyl moiety on the purine ring in the modified enzyme , which suggests that the altered histidine may be located in the adenine region of the metal-nucleotide binding site . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
91,
97
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
192,
199
]
} |
the interactions with sodium dodecyl sulfate ( sds ) of methemerythrin , the anionic derivatives and oxyhemerythrin from phascolopsis gouldii have been examined at 25 degrees c , i = 0.5 m and ph 6.3 and 7.8 . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
77,
84
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
179,
180
]
} |
the inhibitor inactivates both the low- and high-calcium-requiring forms of the calcium-activated proteinase but does not inhibit other proteinases against which it has been tried . | NA | {
"id": "C0030946",
"name": "proteinase",
"pos": [
98,
108
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
136,
147
]
} |
in the right kidney , incorporation of 32p into total phospholipids , and five phospholipid fractions ( phosphatidylcholine , phosphatidylethanolamine , phosphatidylserine , diphosphatidylglycerol and sphingomyelin ) was increased by 25-35 % between 20 and 72 h after uninephrectomy . | NA | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
54,
67
]
} | {
"id": "C0771648",
"name": "phospholipid fractions",
"pos": [
79,
101
]
} |
in the presence of higher concentrations of cellular arachidonic acid , ethanol and methanol stimulated the production of lipoxygenase metabolites , but had no large stimulatory effect on the cyclo-oxygenase metabolite , prostaglandin d2 . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
72,
79
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
84,
92
]
} |
the similarity of free cholesterol exchange in platelets and erythrocytes in vitro and in vivo and the apparent inability of platelets to take up cholesterol esters from lipoproteins suggest that the interaction between normal platelets and normocholesterolemic plasma is limited to cholesterol exchange . | NA | {
"id": "C0008387",
"name": "cholesterol",
"pos": [
23,
34
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
283,
294
]
} |
we demonstrate that artificial triacylglycerol emulsion can indeed substitute for vldl in neutral lipid exchange processes , and further confirm that transfer of core cholesterol ester and triacylglycerol occurs independently of the apolipoproteins present in triacylglycerol-rich lipoproteins and ldl . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
98,
103
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
281,
293
]
} |
the heparin-sensitive binding of 125i-ldl to cell homogenate particulates represents ldl bound to its cell surface receptor as judged from the following criteria : ( a ) it was quantitatively similar to the heparin-sensitive binding of 125i-ldl to intact cells , ( b ) it showed a direct correlation to the receptor-medi... | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
45,
49
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
486,
497
]
} |
arginine , phenylalanine and methionine inhibited the induction of ornithine decarboxylase activity by the tumor promoter to degrees comparable to those elicited by their analogs canavanine and homoarginine , beta-2-thienyl-dl-alanine , and ethionine , respectively . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
0,
8
]
} | {
"id": "C0019877",
"name": "homoarginine",
"pos": [
194,
206
]
} |
the binding was time-and temperature-dependent and the label was displaced by bovine insulin , a1-b29 dodecoyl insulin , proinsulin and insulin a- and b-chains in proportion to their relative activity . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
121,
131
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
136,
143
]
} |
this coincided with a fall in both gsh/gssg ratio and the thiol content of the islets . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
35,
38
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
39,
43
]
} |
cultures of calvaria bone cells which contain mainly two cell types , parathyroid hormone responsive cells ( osteoblast-like ) and prostaglandin e2 responsive cells ( fibroblast-like ) , respond to both low ( 13 v/cm ) and to high ( 54 v/cm ) electric field strength , with no response at intermediate ( 24 v/cm ) field ... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
26,
31
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
167,
177
]
} |
although factor x partially inhibited the binding of 125i-factor xa , factor xa did not inhibit the binding of 125i-factor x , indicating that the zymogen and enzyme bound to different receptors . | NA | {
"id": "C0015520",
"name": "factor xa",
"pos": [
58,
67
]
} | {
"id": "C0015518",
"name": "factor x",
"pos": [
116,
124
]
} |
the role of albumin in mouse sperm capacitation was studied in relation to its activities as a lipid-solubilizing protein and a sterol acceptor . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
12,
19
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
114,
121
]
} |
in summary , results of this investigation suggest 1 ) luteal cells of pregnant rats effectively utilize cholesterol from hdl for maximal steroidogenesis , and 2 ) estradiol may stimulate luteal steroidogenesis , at least in part , by affecting the incorporation or utilization of cholesterol from hdl into the cell . | NA | {
"id": "C0023822",
"name": "cholesterol",
"pos": [
105,
116
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
281,
292
]
} |
dental amalgams prepared from nine commercially available dental amalgam alloys , including high copper ternary , high copper blend , and a conventional alloy , were evaluated for their compressive fatigue behaviour to at least 10 ( 6 ) cycles . | NA | {
"id": "C0011324",
"name": "dental amalgams",
"pos": [
0,
15
]
} | {
"id": "C0011323",
"name": "dental",
"pos": [
58,
64
]
} |
agents that increase the concentration of cyclic amp ( camp ) in platelets ( pge1 , adenosine , dibutyryl camp , forskolin , and papaverine ) also decreased platelet density . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
42,
52
]
} | {
"id": "C0012054",
"name": "dibutyryl camp",
"pos": [
96,
110
]
} |
to determine the relationship between equilibrium binding of thrombin to sites on the platelet surface and the cleavage of membrane glycoprotein v ( gpv ) by thrombin , we examined the effect of active site-modified thrombin ( 1-chloro-3-tosylamido-7-amino-l-2-heptanone thrombin toslysch2-thrombin ) on the binding of n... | NA | {
"id": "C0025248",
"name": "membrane glycoprotein",
"pos": [
123,
144
]
} | {
"id": "C0017968",
"name": "gpv",
"pos": [
373,
376
]
} |
specific identification of fibrin polymers , fibrinogen degradation products , and crosslinked fibrin degradation products in plasma and serum with a new sensitive technique . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
27,
33
]
} | {
"id": "C0163275",
"name": "fibrin degradation products",
"pos": [
95,
122
]
} |
fibrin polymers , plasmic degradation products of fibrinogen , and plasmic degradation products of crosslinked fibrin were detected in the plasma or serum of a patient with disseminated intravascular coagulation . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
0,
6
]
} | {
"id": "C0163275",
"name": "degradation products",
"pos": [
75,
95
]
} |
t cells made up 59 % to 73 % of control peripheral blood mncs and 0.8 % to 2.8 % of peripheral mncs following sheep cell rosetting plus treatment with leu 1 mcab and complement . | NA | {
"id": "C1321301",
"name": "cells",
"pos": [
2,
7
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
116,
120
]
} |
among the species of fibrin studied , monomer lacking fibrinopeptide a alone ( alpha-fibrin ) underwent very rapid clearance by a saturable mechanism that was not evident in relatively sluggish clearance of monomer lacking either fibrinopeptide b alone ( beta-fibrin ) or both fibrinopeptides a and b ( alpha beta-fibrin... | NA | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
54,
70
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
314,
320
]
} |
among the species of fibrin studied , monomer lacking fibrinopeptide a alone ( alpha-fibrin ) underwent very rapid clearance by a saturable mechanism that was not evident in relatively sluggish clearance of monomer lacking either fibrinopeptide b alone ( beta-fibrin ) or both fibrinopeptides a and b ( alpha beta-fibrin... | NA | {
"id": "C0016023",
"name": "fibrinopeptide b",
"pos": [
230,
246
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
314,
320
]
} |
the uniquely rapid and saturable clearance of alpha-fibrin is suggested to involve uptake through the fibrin aggregation site that is blocked by fibrinopeptide a in fibrinogen and beta-fibrin and by tight binding to fibrinogen in soluble complexes formed by alpha beta-fibrin . | NA | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
145,
161
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
269,
275
]
} |
with the addition of bacterial endotoxin ( lipopolysaccharide [ lps ] ) ( 50 micrograms per 10 ( 6 ) cells ) , mra was detectable after only three hours of incubation , and levels peaked at 24 hours . | NA | {
"id": "C0014264",
"name": "bacterial endotoxin",
"pos": [
21,
40
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
43,
61
]
} |
a colony assay method is described for studying dog fibroblast colony development in marrow cells derived from resected ribs . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
52,
62
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
92,
97
]
} |
the assay showed an increased number of fibroblast colony forming units ( cfu-f ) in cell suspensions prepared from resected ribs compared to cell suspensions prepared from bone marrow aspirates or from peripheral blood . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
40,
50
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
142,
146
]
} |
the diagnosis may be delayed if the neurological features are wrongly attributed to an entrapment neuropathy or rheumatoid peripheral neuropathy . | NA | {
"id": "C0027743",
"name": "entrapment neuropathy",
"pos": [
87,
108
]
} | {
"id": "C0031117",
"name": "peripheral neuropathy",
"pos": [
123,
144
]
} |
patients with abdominal aortic aneurysms ( aaas ) have been compared with healthy controls with respect to the serum concentrations of triglyceride , cholesterol , hdl-cholesterol and ( vldl + ldl ) -cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
150,
161
]
} | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
164,
179
]
} |
patients with abdominal aortic aneurysms ( aaas ) have been compared with healthy controls with respect to the serum concentrations of triglyceride , cholesterol , hdl-cholesterol and ( vldl + ldl ) -cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
150,
161
]
} | {
"id": "C0023826",
"name": "vldl",
"pos": [
186,
190
]
} |
there was no statistically significant difference between the patients who had first degree relatives with aaas and the patients without aaas in the family in the serum concentrations of triglyceride , cholesterol , hdl-cholesterol and ( vldl + ldl ) -cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
202,
213
]
} | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
216,
231
]
} |
there was no statistically significant difference between the patients who had first degree relatives with aaas and the patients without aaas in the family in the serum concentrations of triglyceride , cholesterol , hdl-cholesterol and ( vldl + ldl ) -cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
202,
213
]
} | {
"id": "C0023826",
"name": "vldl",
"pos": [
238,
242
]
} |
the opiate receptor antagonists naltrexone and naloxone blocked morphine-induced circling whether given before or during the sessions . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
32,
42
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
47,
55
]
} |
effect of the gut microflora on chick growth and utilisation of protein and energy at different concentrations of dietary protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
64,
71
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
114,
129
]
} |
to indicate their spectrum of aggressiveness , the authors suggest calling typical carcinoids kcc-i , atypical carcinoids kcc-ii , and small cell cancers kcc-iii . | NA | {
"id": "C0007097",
"name": "kcc",
"pos": [
94,
97
]
} | {
"id": "C0262584",
"name": "small cell",
"pos": [
135,
145
]
} |
one had acute promyelocytic leukemia , one had myelofibrosis evoluting to acute undifferentiated leukemia , one had acute nonlymphoid leukemia ( anll ) secondary to hodgkin 's disease , and another had acute leukemia recurring after allogeneic bone marrow transplantation . | NA | {
"id": "C0023487",
"name": "acute promyelocytic leukemia",
"pos": [
8,
36
]
} | {
"id": "C0023467",
"name": "acute nonlymphoid leukemia",
"pos": [
116,
142
]
} |
although no conclusion can be reached regarding the significance of the chromosomal abnormalities in cll , the type of chromosomal abnormalities in these patients suggests that they are the result of chromosomal breakage and abnormal repair . | NA | {
"id": "C0008626",
"name": "of chromosomal abnormalities",
"pos": [
116,
144
]
} | {
"id": "C0376628",
"name": "chromosomal breakage",
"pos": [
200,
220
]
} |
an examination of chromosomal heteromorphisms suggested that the severe hypodiploid clone originated either from a near-triploid cell or from a common precursor cell . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
129,
133
]
} | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
151,
165
]
} |
in order to further evaluate the effect of the nitroxyl moiety on the anticancer activity of nitroxyl labeled analogues of phosphoric n , n ; n ' , n ' ; n '' '' , n '' '' -tris [ 1,2-ethanediyl ] triamide ( tepa ) and phosphorothioic n , n ; n ' , n ' ; n '' '' , n '' '' -tris [ 1,2-ethanediyl ] triamide ( thio-tepa )... | NA | {
"id": "C0020363",
"name": "the hydroxylam",
"pos": [
461,
475
]
} | {
"id": "C0002508",
"name": "and a",
"pos": [
480,
485
]
} |
enhanced polyglutamylation of aminopterin relative to methotrexate in the ehrlich ascites tumor cell in vitro . | NA | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
30,
41
]
} | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
54,
66
]
} |
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