text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the polyglutamylation of aminopterin and methotrexate ( n10-methylaminopterin ) was compared in the ehrlich ascites tumor in vitro . | NA | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
25,
36
]
} | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
41,
53
]
} |
three poly-gamma-glutamyl conjugates of methotrexate and aminopterin were detected , although at an equal ( 1 microm ) extracellular drug concentration , the net accumulation of aminopterin polyglutamates exceeded that for the methotrexate polyglutamyl derivatives by a factor of 9 . | NA | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
57,
68
]
} | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
227,
239
]
} |
when compensation was made for transport differences between these compounds by adjusting the extracellular drug concentrations to achieve equivalent intracellular monoglutamyl substrate levels , the polyglutamylation of aminopterin was still 2.8-fold greater than that for methotrexate , suggesting that aminopterin is ... | NA | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
274,
286
]
} | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
305,
316
]
} |
these findings support a role for the polyglutamylation of aminopterin as a critical element in drug action and as a factor in addition to membrane transport in the disparate antifolate potencies of aminopterin and methotrexate . | NA | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
59,
70
]
} | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
215,
227
]
} |
according to the reactivities of these antibodies with 19 individual tumors , the 13 monoclonal antibodies can be divided into three groups . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
39,
49
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
85,
95
]
} |
rabbit antibodies raised against the major isozymes of cytochrome p-450 isolated from hepatic microsomes of beta-naphthoflavone- ( bnf ) and phenobarbital-treated rats ( cytochrome p-450 bnf-b2 and cytochrome p-450 pb-b2 , respectively ) and against rat liver nadph-cytochrome p-450 reductase were used to localize these... | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
43,
51
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
321,
328
]
} |
this cell surface labeling pattern was virtually identical to that of the nontransformed akr-2b fibroblasts from which akr-mca cells were derived . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
96,
107
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
127,
132
]
} |
two mouse monoclonal antibodies detecting two different epitopes of an activated lymphocyte antigen on adult t-cell leukemia cells . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
56,
64
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
92,
99
]
} |
hybridoma 15a8 produces kappa-igg1 antibodies that react with the surface membranes of the cells of two human breast cancer cell lines but not with a human fibroblast cell line . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
91,
96
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
156,
166
]
} |
the cm-s cell line was established from the bone marrow of a patient suffering from congenital hypoplastic anemia ( syndrome of diamond-blackfan ) . | NA | {
"id": "C0949116",
"name": "congenital hypoplastic anemia",
"pos": [
84,
113
]
} | {
"id": "C1260899",
"name": "syndrome",
"pos": [
116,
124
]
} |
4-demethoxydaunorubicin has sufficient antileukemic activity in both acute lymphocytic leukemia and acute nonlymphocytic leukemia to warrant a prospective comparison , in combination regimens , against the conventional anthracyclines , daunorubicin and/or doxorubicin . | NA | {
"id": "C0020789",
"name": "4-demethoxydaunorubicin",
"pos": [
0,
23
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
236,
248
]
} |
4-demethoxydaunorubicin has sufficient antileukemic activity in both acute lymphocytic leukemia and acute nonlymphocytic leukemia to warrant a prospective comparison , in combination regimens , against the conventional anthracyclines , daunorubicin and/or doxorubicin . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
11,
23
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
256,
267
]
} |
when cells from mass cultures of chick embryo fibroblasts are grown at very low density , some cells yield large clones while others produce smaller clones , and some cells fail to divide at all . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
46,
57
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
167,
172
]
} |
cultures contained essentially two cell types , which could be easily distinguished by the size of their nuclei : small nuclei identified as belonging to precursor cells of neurons and large nuclei corresponding to astroglial cells . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
154,
169
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
226,
231
]
} |
cell generation cycle of spermatogonial germ cells and supporting cells ( future sertoli cells ) on day 9 showed marked prolongation of dna synthetic phase ( s ) , unaltered post-dna synthetic phase ( g2 ) and total cycle ( tc ) and shortening of the pre-dna synthetic phase ( g1 ) indicating a depression in dna synthes... | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
136,
139
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
311,
312
]
} |
by immunoprecipitation of 35s-methionine-labeled cell extracts , norm-2 antibody recognized a 59 kd protein in b16 mouse and in a375 human melanoma cells but not in 3t3 fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
49,
53
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
169,
180
]
} |
we report here that chicken embryo fibroblasts ( cef ) transformed by aev show enhanced tyrosine phosphorylation of a number of cellular polypeptides , including the 36 kd protein , which is phosphorylated in avian sarcoma virus-transformed fibroblasts , and the 42 kd protein , which is phosphorylated in mitogen-stimul... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
35,
46
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
325,
330
]
} |
mutants lacking amino acids 327-345 of wild-type np enter the nucleus but do not accumulate there to the same extent as the wild-type protein , suggesting that this region has a role in nuclear accumulation . | NA | {
"id": "C0028612",
"name": "np",
"pos": [
49,
51
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
134,
141
]
} |
this possibility is further strengthened by similar studies involving the production of fusion proteins in which various amino-terminal sequences of the np gene are fused to the complete chimpanzee alpha 1-globin sequence : when globin cdna was injected into and expressed in oocytes the protein remains exclusively in t... | NA | {
"id": "C0028612",
"name": "np",
"pos": [
153,
155
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
288,
295
]
} |
a particulate fraction containing membrane-bound envelope precursor proteins and the enzyme transglutaminase is combined with cytosolic proteins ; | NA | {
"id": "C0025252",
"name": "membrane",
"pos": [
34,
42
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
136,
144
]
} |
this interaction is cell-type-specific , since particulates derived from fibroblasts and also containing transglutaminase activity can not substitute for those of keratinocytes . | NA | {
"id": "C0007634",
"name": "cell-type",
"pos": [
20,
29
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
73,
84
]
} |
the cross-linking of proteins of the particulate fraction ( membrane proteins ) is promoted by the presence of involucrin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
21,
29
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
60,
77
]
} |
the results indicated that the binding of endotoxin was promoted neither by natural antibodies directed against the endotoxin nor by proteins known to combine with endotoxins : immunoglobulins , albumin , or fibronectin ; | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
133,
141
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
195,
202
]
} |
potent adjuvant action of lipopolysaccharides possessing the o-specific polysaccharide moieties consisting of mannans in antibody response against protein antigen . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
26,
45
]
} | {
"id": "C0069180",
"name": "o-specific",
"pos": [
61,
71
]
} |
the common feature in the structures of klebsiella o3 lps and o5 lps is their o-specific polysaccharide chains consisting of the mannose homopolysaccharides ( mannans ) . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
54,
57
]
} | {
"id": "C0069180",
"name": "o-specific polysaccharide",
"pos": [
78,
103
]
} |
lps from e. coli o8 and o9 , the o-specific polysaccharide chains of which consist of the mannans , also exhibited much stronger adjuvant activity than do lps from e. coli o55 and o127 , and the strength of the adjuvant activities of the former two was comparable to that of lps from klebsiella o3 and o5 . | NA | {
"id": "C0069180",
"name": "o-specific polysaccharide",
"pos": [
33,
58
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
275,
278
]
} |
from the present results it can be concluded that lps possessing the o-specific polysaccharide moieties consisting of the mannans exhibit extraordinarily strong adjuvant activity in augmenting antibody response against protein antigen . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
50,
53
]
} | {
"id": "C0069180",
"name": "o-specific polysaccharide",
"pos": [
69,
94
]
} |
the sensitivity of female rat renal cells appears to relate to the higher activity of alcohol dehydrogenase found in the female rat kidney , which metabolizes allyl alcohol to the highly reactive aldehyde , acrolein . | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
196,
204
]
} | {
"id": "C0001204",
"name": "acrolein",
"pos": [
207,
215
]
} |
nickel ( ii ) was associated with the histone and non-histone nuclear proteins as well as the dna in rat liver and kidney chromatin . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
38,
45
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
62,
78
]
} |
enzymes of the mfo system , such as aminopyrine demethylase and aryl hydrocarbon hydroxylase , were assayed and the content of cytochrome p-450 was determined . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
64,
92
]
} | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
127,
143
]
} |
of the other alkylating agents , 4-hydroperoxycylophosphamide ( sometimes used in vitro in place of cyclophosphamide ) , busulphan , dianhydrogalactitol , aziridinylbenzoquinone ( azq ) , and dacarbazine have a t0.95 of between 2 and 24 h , while ifosfamide and pentamethylmelamine are both stable in aqueous solution fo... | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
100,
116
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
247,
257
]
} |
with the use of this method the nucleophilicity of n-ac-met toward enzymatically produced n-acetoxy and n-sulfonoxy derivatives of 2-af and 2-aaf , respectively , and toward the synthetic model ester , n-acetoxy-2-acetylaminofluorene ( n-oac-2-aaf ) , was determined . | NA | {
"id": "C0000248",
"name": "2-aaf",
"pos": [
140,
145
]
} | {
"id": "C0001011",
"name": "n-acetoxy-2-acetylaminofluorene",
"pos": [
202,
233
]
} |
as long as the adult type of epidermal differentiation is not sufficiently developed ( i.e. , prior to postnatal day 5 ) , topical application of the phorbol ester tumor promoter 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) causes neither morphological alterations nor a measurable induction of cellular proliferation a... | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
150,
163
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
198,
205
]
} |
in order to evaluate exposure of betel quid chewers to n-nitroso compounds , saliva and urine samples were collected from chewers of betel quid with or without tobacco , from tobacco chewers , from cigarette smokers and from people with no such habit , and were analysed for the presence of n-nitrosamines by gas chromat... | NA | {
"id": "C0028199",
"name": "nitroso compounds",
"pos": [
57,
74
]
} | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
293,
305
]
} |
the betel nut-specific alkaloid , arecoline , was present at high levels in the saliva of betel quid chewers with or without tobacco . | NA | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
23,
31
]
} | {
"id": "C0003753",
"name": "arecoline",
"pos": [
34,
43
]
} |
to answer directly the question of whether angiotensin ii exists in the brain , independent of blood-borne angiotensin , and to quantify the amounts in different parts of the central nervous system , a sensitive radioimmunoassay was used to measure extracts of male adult rat brain hypothalamus and cortex after purifica... | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
43,
57
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
107,
118
]
} |
recovery of adenosine triphosphate after myocardial ischemia is limited by the slow adenine nucleotide de novo synthesis and the availability of precursors of the nucleotide salvage pathways . | NA | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
12,
34
]
} | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
84,
102
]
} |
therefore , only adenosine infusion resulted in a measurable increase of adenosine triphosphate levels after 3 hours of reperfusion , but over a longer time period , ribose or 5-amino-4-imidazol-carboxamide riboside also can be expected to replenish reduced myocardial adenosine triphosphate faster than adenine nucleoti... | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
17,
26
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
269,
291
]
} |
after 3 minutes of reperfusion , the adenylate charge was restored to control by the rephosphorylation of adenosine mono- and diphosphate , but adenosine triphosphate was still reduced by 45 % . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
106,
115
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
144,
166
]
} |
first : although adenine nucleotide repletion occurs very slowly , the adenylate charge was restored after 3 minutes , indicating rapid resumption of mitochondrial adenosine triphosphate production . | NA | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
17,
35
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
164,
186
]
} |
consequently , adenosine radioligands which are useful in brain such as l- [ 3h ] phenylisopropyladenosine , [ 3h ] cyclohexyladenosine , [ 3h ] -2-chloroadenosine and l- [ 125i ] hydroxyphenylisopropyladenosine are of limited usefulness in heart , due to a high ratio of nonspecific to specific binding . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
15,
24
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
187,
211
]
} |
consequently , adenosine radioligands which are useful in brain such as l- [ 3h ] phenylisopropyladenosine , [ 3h ] cyclohexyladenosine , [ 3h ] -2-chloroadenosine and l- [ 125i ] hydroxyphenylisopropyladenosine are of limited usefulness in heart , due to a high ratio of nonspecific to specific binding . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
15,
24
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
146,
163
]
} |
the binding reached equilibrium within 30 minutes , and was dissociated by the addition of 100 microm l-norepinephrine . l-isomers of norepinephrine and epinephrine were over 10 times more potent than d-isomers in displacing the binding . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
104,
118
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
153,
164
]
} |
porcine aortic smooth muscle cells that were exposed to serum-free dulbecco 's modified minimum essential medium for 24 hours were found to release a somatomedin-like molecule that could be detected by a specific radioimmunoassay for somatomedin-c . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
150,
161
]
} | {
"id": "C0021665",
"name": "somatomedin-c",
"pos": [
234,
247
]
} |
head-out water immersion significantly suppressed plasma concentrations of both norepinephrine ( 704 +/- 72 to 475 +/- 70 pg/ml , p less than 0.005 ) and epinephrine ( 121 +/- 33 to 57 +/- 10 pg/ml , p less than 0.05 ) in all seven patients studied . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
80,
94
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
154,
165
]
} |
since lipoprotein levels contribute strongly to the risk of chd and cvd , we examined the relationship of resting heart rate to plasma concentrations of high-density ( hdl ) , low-density ( ldl ) , and very low-density ( vldl ) lipoproteins , apolipoprotein ( apo ) a-i and a-ii , and serum concentrations of lipoprotein... | NA | {
"id": "C0023825",
"name": "very low-density",
"pos": [
202,
218
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
372,
384
]
} |
influence of coronary collateral blood flow on the development of exertional ischemia and q wave infarction in patients with severe single-vessel disease . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
77,
85
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
97,
107
]
} |
collateral flow did not prevent ischemia on exercise thallium imaging in patients without q wave infarction : 30 of 33 ( 91 % ) with collateral flow had reversible thallium defects compared with 24 of 24 ( 100 % ) without collateral flow ( p = ns ) . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
32,
40
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
97,
107
]
} |
collateral flow may protect from q wave infarction but does not prevent exercise ischemia on thallium imaging . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
40,
50
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
81,
89
]
} |
reversible cryothermal mapping may provide additional important information not obtained by standard electrogram mapping of ventricular tachycardia that may help guide surgical therapy of recurrent ventricular tachycardia . | NA | {
"id": "C0042514",
"name": "ventricular",
"pos": [
124,
135
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
210,
221
]
} |
a solid-phase , second-antibody technique ( immunobead second antibody ; bio-rad laboratories ) was used to separate free enzyme from antigen-antibody complexes . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
23,
31
]
} | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
134,
160
]
} |
both apo ai ( 48 % ) and apo aii ( 5.5 % ) were greatly diminished and apo e was present in remarkably high amounts ( 39 % ) with two additional isoforms ( apo e ' 1 and apo e ' 2 ) . | NA | {
"id": "C0003595",
"name": "apo e",
"pos": [
71,
76
]
} | {
"id": "C0052198",
"name": "apo",
"pos": [
170,
173
]
} |
we have recently shown that peripheral blood mononuclear cells from patients sensitive to the house dust mite , d. pteronyssinus , will proliferate in vitro in response to the purified major allergen , antigen p1 . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
191,
199
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
202,
209
]
} |
we found , that both spleen and peritoneal cells , but not thymocytes , exerted an anti-chondrocyte cytotoxic effect . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
43,
48
]
} | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
88,
99
]
} |
in patients with detectable nasal secretory iga , 11s iga concentrations correlated significantly ( r = 0.57 ; p less than 0.001 ) with concentrations of free sp . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
34,
47
]
} | {
"id": "C0036538",
"name": "sp",
"pos": [
159,
161
]
} |
functionally , there was a decrease in proliferative responses to some mitogens and to allogeneic cells , and a lack of t cell help for in vitro b lymphocyte differentiation into immunoglobulin secreting cells . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
87,
103
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
204,
208
]
} |
in contrast to convalescent hepatitis b patients , who exhibit the ability to elicit a specific immune response to hbsag , patients with chronic hepatitis b virus ( hbv ) infection are markedly hyporesponsive to hbsag and show a decrease in the normal ratio of okt4-positive ( helper/inducer ) to okt8-positive ( suppres... | NA | {
"id": "C0019163",
"name": "hepatitis b",
"pos": [
28,
39
]
} | {
"id": "C0524909",
"name": "chronic hepatitis b",
"pos": [
137,
156
]
} |
in cases of spondylolysis and spondylolisthesis , interbody fusion should be coupled with some manner of posterior internal fixation . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
12,
25
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
30,
47
]
} |
in most conditions , the retinoids produce a maximal effect in about 8 weeks ( at the highest tolerated dose ) , with a slow recurrence of symptoms usually occurring within several weeks following cessation of treatment - except in the treatment of cystic acne with isotretinoin . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
25,
34
]
} | {
"id": "C0022265",
"name": "isotretinoin",
"pos": [
266,
278
]
} |
thirteen cases of hemolytic anemia ( including two cases of hemolytic uremic syndrome ) following postnatally acquired rubella infection reported in a nationwide epidemic of rubella in japan in 1975-1977 are reviewed in this article , and another case is added . | NA | {
"id": "C0002878",
"name": "hemolytic anemia",
"pos": [
18,
34
]
} | {
"id": "C0019061",
"name": "hemolytic uremic syndrome",
"pos": [
60,
85
]
} |
compared with results obtained when only methyldopa was taken , sodium sulfate taken with methyldopa increased the proportion of drug excreted as methyldopa sulfate expressed as the percentage of all urinary metabolites ( 66.0 % +/- 5.3 % and 50.1 % +/- 7.5 % ; means +/- sd ) . | NA | {
"id": "C0074769",
"name": "sodium sulfate",
"pos": [
64,
78
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
157,
164
]
} |
when sodium sulfate was taken with methyldopa , there was a significant correlation between platelet pst activities and percentages of metabolites excreted as methyldopa sulfate ( r = 0.545 ; p less than 0.01 ) . | NA | {
"id": "C0074769",
"name": "sodium sulfate",
"pos": [
5,
19
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
170,
177
]
} |
plasma aldosterone , 18-hydroxycorticosterone ( 18-oh-b ) , 18-hydroxydeoxycorticosterone ( 18-oh-doc ) , corticosterone , cortisol and prolactin levels were determined during an angiotensin ii infusion at increasing rates both with and without a simultaneous infusion of dopamine in seven normotensive subjects , in ten... | NA | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
21,
45
]
} | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
106,
120
]
} |
the 'degrading activity ' of serum was correlated with the serum albumin concentration , and the effect was also given by purified human and bovine serum albumin , although it was not seen with other serum proteins . | NA | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
59,
72
]
} | {
"id": "C0036774",
"name": "bovine serum",
"pos": [
141,
153
]
} |
during high dietary sodium intake ( 350 mmol/day ) for 4 days no changes in urinary excretion of pge2 , pgf2 alpha , noradrenaline or adrenaline were noted , whereas plasma renin activity ( pra ) and urinary aldosterone excretion were suppressed . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
117,
130
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
134,
144
]
} |
over 60 % of the myocardial infarction group lay in the area of high platelet volume and low count compared with 13 % of the ischaemic heart disease control group and 38 % of the asymptomatic group . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
17,
38
]
} | {
"id": "C0151744",
"name": "of the ischaemic heart disease",
"pos": [
118,
148
]
} |
ph-dependent metabolism and flow-dependent excretion were identified as two factors liable to obscure the demonstration of the ph-dependency of the urinary excretion rate of pge in man . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
13,
23
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
156,
165
]
} |
adrenaline released into the circulation can be taken up by the sympathetic nerve ending and as it is re-released as a co-transmitter it enhances exocytotic noradrenaline release by stimulating prejunctional beta-adrenoceptors and as a consequence it contributes to postjunctional alpha 1-adrenoceptor-induced vasoconstr... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
157,
170
]
} |
adrenaline and noradrenaline were infused in cumulative doses into the brachial artery of six healthy volunteers and changes in forearm blood flow ( fbf ) were measured by plethysmography . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
15,
28
]
} |
it is concluded that postjunctional alpha 1- and alpha 2-adrenoceptors are involved in the vasoconstriction caused by exogenous adrenaline and noradrenaline in man . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
128,
138
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
143,
156
]
} |
catecholamines compete for [ 125i ] be2254 binding stereospecifically and with the characteristic alpha-adrenergic potency series ( - ) -adrenaline greater than or equal to ( - ) -noradrenaline much greater than ( - ) -isoprenaline . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
0,
14
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
219,
231
]
} |
catecholamines compete for [ 125i ] be2254 binding stereospecifically and with the characteristic alpha-adrenergic potency series ( - ) -adrenaline greater than or equal to ( - ) -noradrenaline much greater than ( - ) -isoprenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
137,
147
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
180,
193
]
} |
the alpha 1-adrenoceptor selective antagonist prazosin is much more potent than yohimbine in competing for the [ 125i ] be2254 binding sites , which suggests that the alpha-adrenoceptor identified is predominantly of the alpha 1 subtype . | NA | {
"id": "C0001638",
"name": "alpha 1-adrenoceptor",
"pos": [
4,
24
]
} | {
"id": "C0034784",
"name": "alpha-adrenoceptor",
"pos": [
167,
185
]
} |
the postsynaptic alpha-adrenoceptor of rat aorta is of the alpha 1-subtype , but may differ from the alpha 1-adrenoceptor of rabbit and guinea pig aortae , based on comparison of relative potencies of selected agonists . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptor",
"pos": [
17,
35
]
} | {
"id": "C0001638",
"name": "alpha 1-adrenoceptor",
"pos": [
101,
121
]
} |
five ( 33 % ) patients had severe cardiorespiratory failure and underwent hemodynamic monitoring before and during infusion of dobutamine hydrochloride ( dobutamine ) . | NA | {
"id": "C0700450",
"name": "dobutamine hydrochloride",
"pos": [
127,
151
]
} | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
154,
164
]
} |
in stage 1 or 2 lymphoma , non-hodgkin 's patients with negative noninvasive findings and all hodgkin 's patients , regardless of their noninvasive findings , should undergo lymphangiography . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
16,
24
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
27,
41
]
} |
this asymmetric organization is preferentially maintained through complex , and at present , poorly understood noncovalent interactions between specific membrane lipids and proteins ( in particular , a stabilizing role for the skeletal protein spectrin and band 4.1 have been implicated ) , although other considerations... | NA | {
"id": "C0025249",
"name": "membrane",
"pos": [
153,
161
]
} | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
329,
341
]
} |
patients with very high theophylline concentrations ( greater than 50 micrograms/ml ) , however , usually vomit the oac and may require charcoal hemoperfusion . | NA | {
"id": "C0001275",
"name": "oac",
"pos": [
116,
119
]
} | {
"id": "C0007955",
"name": "charcoal",
"pos": [
136,
144
]
} |
although an atrioventricular nodal bypass was thus present and could account for the preexcitation and for reentrant tachycardias , there is also the anatomic basis for an automatic arrhythmia originating within one or more of the purkinje cell tumors , particularly the one directly within the his bundle . | NA | {
"id": "C0032915",
"name": "preexcitation",
"pos": [
85,
98
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
182,
192
]
} |
these individuals differ in several respects from patients who experience urticaria and/or angioedema after aspirin administration , and differing mechanisms may be involved . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
74,
83
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
91,
101
]
} |
for the treatment of cystic changes of the pancreas , it is essential to distinguish cysts and pseudocysts from neoplasm . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
85,
90
]
} | {
"id": "C0027651",
"name": "neoplasm",
"pos": [
112,
120
]
} |
patients in an early state of mechanical bowel obstruction , with unspecific clinical symptoms , negative laboratory findings and no evidence of ileus in plain abdominal x-ray , are a pitfall for diagnosis and therapeutic decisions . | NA | {
"id": "C0021843",
"name": "of",
"pos": [
27,
29
]
} | {
"id": "C1258215",
"name": "ileus",
"pos": [
145,
150
]
} |
the former patients appear to be in double jeopardy with respect to synchronous neoplasms , these being more prevalent and less accessible than in patients with non-occluding tumors . | NA | {
"id": "C0027663",
"name": "synchronous neoplasms",
"pos": [
68,
89
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
175,
181
]
} |
the diet consisted of 76 % of calories as carbohydrates ( 80 % oligosaccharides , 20 % mono- and disaccharides ) , 10 % as fat ( more than 90 % c18 fatty acids ) and 14 % as protein ( oligo- and polypeptides ; 11.8 g nitrogen per day ) . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
63,
79
]
} | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
97,
110
]
} |
ti treatment induced no significant changes in body weight and total amount of dna content in the pancreas , but pancreatic wet weight , total pancreatic protein and amylase , and the concentration of total protein and amylase relative to dna were significantly decreased at 6 or 12 hr posttreatment , with a partial ret... | NA | {
"id": "C0005911",
"name": "changes in",
"pos": [
36,
46
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
128,
134
]
} |
in patients with myasthenia gravis , spinal muscular atrophy and motor neurone disease we have found that the neuromuscular jitter may increase during recordings of several minutes of continuous voluntary activation at steady innervation rates . | NA | {
"id": "C0026847",
"name": "spinal muscular",
"pos": [
37,
52
]
} | {
"id": "C0085084",
"name": "motor neurone disease",
"pos": [
65,
86
]
} |
naf activation , a measure of interaction of the nucleotide regulatory component ( g/f ) with the catalytic unit of the adenylate cyclase was similar in blm from uuo and control kidneys . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
0,
3
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
157,
158
]
} |
iri increased progressively during gestation , attaining 39.2 +/- 6.5 u/g pancreas in the third trimester , 7-fold higher than that in the adult . | NA | {
"id": "C0032961",
"name": "gestation",
"pos": [
35,
44
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
90,
105
]
} |
thus , leucine exerted a dual effect on the secretion of glucagon , the inhibitory effect of leucine prevailing at a high concentration of the branched chain amino acid and when glucagon secretion was already stimulated by arginine or glutamine . | NA | {
"id": "C0023401",
"name": "leucine",
"pos": [
7,
14
]
} | {
"id": "C0002521",
"name": "branched chain amino acid",
"pos": [
143,
168
]
} |
conditioned media obtained from these chondrocytes stimulated dna synthesis and proliferation when added to separate cultures of chondrocytes and the closely related osteoblast-like cells , but were not very effective in skin fibroblasts isolated from the same fetuses , as judged by [ 3h ] thymidine incorporation and c... | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
38,
50
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
182,
187
]
} |
analysis of radioautograms of cell surface camp-binding proteins from confluent monolayer tumor cells , photoaffinity labeled with [ 32p ] 8-n3-camp and subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed two major 32p-labeled protein bands which were indistinguishable from the 49,000 and 55... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
56,
63
]
} | {
"id": "C0599220",
"name": "subunits",
"pos": [
343,
351
]
} |
the molecular size and biological activity in the nsila and sulfation factor assays suggest that our sheep nsila is analogous to somatomedins purified from other species of animals . | NA | {
"id": "C0028318",
"name": "nsila",
"pos": [
50,
55
]
} | {
"id": "C0037657",
"name": "somatomedins",
"pos": [
129,
141
]
} |
the relationship between salivary chloride concentration and mean intake of 0.15 m nacl solution was also u shaped , with the minimal nacl intake associated with a salivary chloride concentration of 54 meq/liter . | NA | {
"id": "C0037494",
"name": "nacl",
"pos": [
83,
87
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
173,
181
]
} |
despite evidence of increased sympathetic activity , and rise in plasma catecholamines , csf epinephrine fell after hemorrhage and csf norepinephrine did not change . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
93,
104
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
135,
149
]
} |
gtp , the gtp analog 5'-guanylyl-imidodiphosphate , and itp stimulated adenylate cyclase activity in the presence or absence of exogenous hormone ; | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
0,
3
]
} | {
"id": "C0018366",
"name": "guanylyl-imidodiphosphate",
"pos": [
24,
49
]
} |
these results indicate that ss-28-binding sites are present only in those cell types in which somatostatin is known to regulate secretory functions . | NA | {
"id": "C0074854",
"name": "ss-28",
"pos": [
28,
33
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
94,
106
]
} |
when the sympathomimetics norepinephrine , epinephrine , and isoproterenol were added to the medium , androgen production in response to hcg was enhanced by 100-300 % . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
26,
40
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
43,
54
]
} |
glutamic acid dimethyl ester ( gdme ) and glutamic acid gamma-methyl ester ( gmme ) also partially blocked homocysteine-induced seizures , but monosodium glutamate and glutamic acid gamma-monoethyl ester ( gmee ) had only a slight effect . | NA | {
"id": "C0037511",
"name": "monosodium glutamate",
"pos": [
143,
163
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
168,
181
]
} |
seizures were classified according to the revised international classification of epileptic seizures as partial ( simple or complex ) , generalized , or partial secondarily generalized . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
0,
8
]
} | {
"id": "C0014544",
"name": "epileptic seizures",
"pos": [
82,
100
]
} |
the activity of enzymes involved in anion and cation transport , the concentration of intracellular potassium ( k+i ) , and the transmembrane potential ( em ) were determined following acute and chronic exposure of primary astroglial cultures to micromolar concentrations of phenytoin ( pht ) . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
36,
41
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
282,
283
]
} |
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