text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the kinetic profiles of diazepam ( dzp ) were investigated in plasma , erythrocytes , and discrete brain areas in the rat , and the effects of valproic acid ( vpa ) , given as sodium valproate , on kinetic parameters were analyzed . | NA | {
"id": "C0042291",
"name": "valproic",
"pos": [
143,
151
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
176,
192
]
} |
through electroencephalographic recording of an experimentally induced epileptic seizure , existence of the `` '' auricular reflex epilepsy '' '' described in about 30 reports dating from the past century is now objectively demonstrated . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
71,
80
]
} | {
"id": "C0270857",
"name": "reflex epileps",
"pos": [
124,
138
]
} |
the possibility that rol exerts its anticarcinogenic effects by inhibiting certain forms of the cytochrome p-450 isoenzymes required for activation of precarcinogens , such as afb and cpp but not those enzymes required by ba , bp , dmba , and mca , is discussed . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
113,
123
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
202,
209
]
} |
the n-glycosidically linked glycans in the large subunit ( ha1 ) of the hemagglutinin from fowl plague virus , strain dutch ( containing about 15 % , w/w , of carbohydrates ) , were liberated by alkaline hydrolysis , and were filtrated through bio-gel as the re-n-acetylated oligosaccharide alditols . | NA | {
"id": "C0032594",
"name": "glycans",
"pos": [
28,
35
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
275,
290
]
} |
the major ha1 glycans , which are not sialylated , were thus found to comprise about 40 % , 30 % and 20 % ( mol/mol ) , respectively , of biantennary intersected , biantennary , and triantennary n-acetyllactosaminic ( 'complex ' ) oligosaccharides . | NA | {
"id": "C0032594",
"name": "glycans",
"pos": [
14,
21
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
231,
247
]
} |
about two thirds of the internal glcnac residues in these glycans are substituted by fuc ( alpha 1 -- -- 6 ) , all the triantennary species carry the third gal ( beta 1 -- -- 4 ) glcnac ( beta 1 -- -- unit at the man ( alpha 1 -- -- 6 ) -branch , and roughly one fourth of the n-acetyllactosamine units in the non-inters... | NA | {
"id": "C0032594",
"name": "glycans",
"pos": [
58,
65
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
338,
354
]
} |
analysis of the modified peptides shows that the active-site lys-258 , which in the holoenzyme binds the coenzyme pyridoxal 5'-phosphate , is labeled in both isozymes . | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
105,
113
]
} | {
"id": "C0034266",
"name": "pyridoxal 5",
"pos": [
114,
125
]
} |
this means that a polycation-bound enzyme is localized in the hydrophobic nucleus of the complex , whereas the polyanion-bound enzyme sits on the hydrophilic shell of the complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
35,
41
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
127,
133
]
} |
structural studies on the o-specific polysaccharide of citrobacter pcm 1487 lipopolysaccharide , using methylation analysis , smith degradation and 1h-nmr spectroscopy , indicate that it consists of the trisaccharide repeating units ( formula , see text ) in this structure , 4-deoxy-d-arahex stands for 4-deoxy-d-arabin... | NA | {
"id": "C0069180",
"name": "o-specific polysaccharide",
"pos": [
26,
51
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
76,
94
]
} |
the antigenic determinant recognized by the monoclonal antibody that had been raised against synthetic human interferon-alpha 1 ( ifn-alpha 1 ) fragment 111-166 [ arnheiter , h. , thomas , r.m. , leist , t. , fountoulakis , m. , and gutte , b . ( 1981 ) nature ( lond . ) 294 , 278-280 ] and that cross-reacted with huma... | NA | {
"id": "C0021734",
"name": "ifn-alpha 2",
"pos": [
336,
347
]
} | {
"id": "C0002199",
"name": "ifn",
"pos": [
354,
357
]
} |
the antigenic determinant recognized by the monoclonal antibody that had been raised against synthetic human interferon-alpha 1 ( ifn-alpha 1 ) fragment 111-166 [ arnheiter , h. , thomas , r.m. , leist , t. , fountoulakis , m. , and gutte , b . ( 1981 ) nature ( lond . ) 294 , 278-280 ] and that cross-reacted with huma... | NA | {
"id": "C0021734",
"name": "ifn-alpha 2",
"pos": [
336,
347
]
} | {
"id": "C0021747",
"name": "interferon",
"pos": [
480,
490
]
} |
the non-specific cleavage of dna by type ii restriction endonucleases ( bamhi , bsuri , ecori , ecorv , hindiii , psti and sali ) can be effectively suppressed by spermidine in millimolar concentrations , regardless of whether the non-specific cleavage is induced by high concentrations of enzyme under optimal buffer co... | NA | {
"id": "C0011524",
"name": "type ii restriction endonucleases",
"pos": [
36,
69
]
} | {
"id": "C0011516",
"name": "ecori",
"pos": [
88,
93
]
} |
under routine assay conditions r. arrhizus pyruvate carboxylase shows significant activation by acyl derivatives of coenzyme a with long chain acyl coa being more effective than acetyl-coa . | NA | {
"id": "C0001374",
"name": "long chain acyl coa",
"pos": [
132,
151
]
} | {
"id": "C0001026",
"name": "acetyl-coa",
"pos": [
178,
188
]
} |
subsequent dna sequence analysis reported here reveals , however , that the encoded protein is in fact manganese superoxide dismutase , a mitochondrial matrix protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
84,
91
]
} | {
"id": "C0949610",
"name": "mitochondrial",
"pos": [
138,
151
]
} |
the pattern of neutral glycosphingolipids labelled from [ 14c ] galactose was slightly modified with time of labelling in either lymphoid cell line : the first labelled glycosphingolipid was lactosylceramide ( laccer ) in the normal line and globotetraosylceramide ( gbose4cer ) in the fabry line . | NA | {
"id": "C0600570",
"name": "neutral",
"pos": [
15,
22
]
} | {
"id": "C0017978",
"name": "glycosphingolipid",
"pos": [
169,
186
]
} |
the size distribution of the 20 aminoacyl-trna synthetases from wild-type chinese hamster ovary ( cho ) cells and from the mutant cell line tsh1 , containing a temperature-sensitive leucyl-trna synthetase , was determined by gel filtration . | NA | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
32,
58
]
} | {
"id": "C0023414",
"name": "leucyl-trna synthetase",
"pos": [
182,
204
]
} |
nine aminoacyl-trna synthetases , specific for arginine , aspartic acid , glutamic acid , glutamine , isoleucine , leucine , lysine , methionine and proline , which coeluted as high-mr entities ( mr approximately 1.2 x 10 ( 6 ) ) , were further co-purified to yield a multienzyme complex , the polypeptide composition of... | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
74,
87
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
90,
99
]
} |
two aminopeptidases ( i and ii ) , hydrolysing basic termini , were purified to homogeneity ( as judged by polyacrylamide gel electrophoresis ) from human quadriceps muscle by anion-exchange chromatography and preparative electrophoresis . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
6,
7
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
176,
181
]
} |
seventeen monoclonal antibodies specific for igm and one kappa light chain-specific antibody were used to test the effect of immunoglobulin ( ig ) -specific antibodies on b cell activation . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
10,
31
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
157,
167
]
} |
examination of the fate of bound egf in cells washed and incubated for 2 h at 37 degrees c shows that some 500-fold more egf per mg protein is retained on the surface of a431 cells compared to ag2804-transformed fibroblasts , a difference which probably explains the unusual persistence of the egf effect on protein brea... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
40,
45
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
212,
223
]
} |
both glycophorins bind to wheat germ lectin and share a common protein antigenic determinant recognised by a monoclonal antibody ( gp 29.4 ) , but they differ significantly in their carbohydrate components : whilst both glycophorins contain mainly o-linked sugars , glycophorin ma contains in addition at least one n-lin... | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
37,
43
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
63,
70
]
} |
from a panel of cloned interleukin-2-dependent murine t-lymphocyte lines , several clones were identified that secreted high titers of one or more of the colony-stimulating factors ( csfs ) : granulocyte-macrophage csf , multi-csf ( or interleukin 3 ) , and human eosinophil csf . | NA | {
"id": "C0009392",
"name": "colony-stimulating factors",
"pos": [
154,
180
]
} | {
"id": "C0021757",
"name": "interleukin 3",
"pos": [
236,
249
]
} |
the anterograde transport of lectin-conjugated horseradish peroxidase ( wga-hrp ) was here employed in order to visualize crossed corticothalamic efferents of the motor cortex in rats and cats . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
47,
69
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
72,
79
]
} |
the fate of wheat germ agglutinin-conjugated horseradish peroxidase ( wga/hrp ) subsequent to its uptake and retrograde axonal transport in abducens motoneurons of the monkey was studied using histochemical localization of wga/hrp reaction product and light microscopy . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
45,
67
]
} | {
"id": "C0078473",
"name": "wga/hrp",
"pos": [
223,
230
]
} |
injections of wga/hrp into monkey lateral rectus muscles produced a pattern of labelled motoneurons like that obtained with native hrp . | NA | {
"id": "C0078473",
"name": "wga/hrp",
"pos": [
14,
21
]
} | {
"id": "C0019941",
"name": "hrp",
"pos": [
131,
134
]
} |
in contrast to the native hrp data , wga/hrp injections consistently labelled additional neuronal populations in the ipsilateral medial vestibular nucleus and contralateral dorsal medullary reticular formation . | NA | {
"id": "C0019941",
"name": "hrp",
"pos": [
26,
29
]
} | {
"id": "C0078473",
"name": "wga/hrp",
"pos": [
37,
44
]
} |
the molecular mass estimation of the two types of glycans by sds-polyacrylamide gel electrophoresis and the sugar composition of aminopeptidase from a+ and a- rabbits strongly suggested the presence of eight n-linked complex glycans and two o-linked oligosaccharides bearing the human group antigenicity . | NA | {
"id": "C0032594",
"name": "glycans",
"pos": [
50,
57
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
250,
266
]
} |
the interconversions of the inositol-containing lipids ( pi , pi-p and pi-p2 ) and their products ( dg , inositol phosphates and pa ) in human and rabbit neutrophils stimulated with fmetleuphe and pma have been examined . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
28,
36
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
105,
124
]
} |
bradykinin produced net increases in the level of [ 3h ] inositol phosphates , especially of [ 3h ] inositol trisphosphate which is formed transiently and most rapidly . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
57,
76
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
100,
108
]
} |
the reactivity of the pyridoxal phosphate-inhibited enzyme with different electron acceptors suggests that the observed inhibition is due to the dissociation of succinate dehydrogenase from the enzyme complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
52,
58
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
194,
208
]
} |
the two synthetic lecithins , pl i ( 1-myristoyl-2-12-n- ( 4-azido-2-nitrophenyl ) aminododecanoyl-sn-glycero-3-phosphocholine ) and pl ii ( 1-myristoyl-2- ( 2-azido-4-nitrobenzoyl ) -sn-glycero-3-phosphocholine ) , are able to reactivate the non-active purified apobdh as well as the non-photoactive homologs , indicati... | NA | {
"id": "C0031617",
"name": "lecithins",
"pos": [
18,
27
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
411,
430
]
} |
no evidence was obtained for the presence of a ca2+-translocating atpase [ ca2+ + mg2+ ) -atpase ) in the chromaffin granules . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
47,
50
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
90,
96
]
} |
the rate of synthesis of map and the levels of map mrna change coordinately during the acute phase response to inflammation . | NA | {
"id": "C0001349",
"name": "acute phase response",
"pos": [
87,
107
]
} | {
"id": "C0021368",
"name": "inflammation",
"pos": [
111,
123
]
} |
perfusion with dopamine -- containing medium ( 10 ( -4 ) m ) leads to a decrease in the amplitude of eps recorded in the neostriatum upon electrical stimulation of zona compacta of substantia nigra , indicating that dopamine release from dopaminergic terminals of nigro -- striatal neurons decreases in response to ap . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
15,
23
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
238,
250
]
} |
since each enzyme is coded by a single structural gene , these results suggest that the isozymes present late in development arise from the synthesis of the same polypeptides with altered post-translational modifications . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
11,
17
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
88,
96
]
} |
species-specific monoclonal antibodies ( mabs ) have been raised against the oocyte nuclear protein of x. borealis b3 , that is equivalent to protein n1 of x. laevis . | NA | {
"id": "C0028589",
"name": "nuclear protein",
"pos": [
84,
99
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
142,
149
]
} |
both insulin biosynthetic rates ( as measured by 3h-leucine incorporation into proinsulin ) and proinsulin mrna levels increased twofold . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
5,
12
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
96,
106
]
} |
dexamethasone injection resulted in an increase in insulin biosynthesis and proinsulin mrna in these animals , while serum glucose did not increase . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
51,
58
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
76,
86
]
} |
pancreatic insulin content became severely depleted relative to saline-injected , stz-treated animals , and there was no response of levels of proinsulin mrna . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
11,
18
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
143,
153
]
} |
six obese , non-insulin-dependent diabetic subjects were studied before and 3 mo after treatment with the sulfonylurea gliclazide , 40-80 mg b.i.d . | NA | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
106,
118
]
} | {
"id": "C0017631",
"name": "gliclazide",
"pos": [
119,
129
]
} |
because these data indicate that glyburide 's actions are glucose dependent , we propose that the sulfonylurea is probably acting to increase glucose transport , thus allosterically increasing the activity of a synthase phosphatase by glucose-6-p . | NA | {
"id": "C0017628",
"name": "glyburide 's",
"pos": [
33,
45
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
98,
110
]
} |
pge inhibited the camp-independent stimulation of glycogenolysis resulting from phenylephrine or angiotensin ii exposure ( rate of glycogenolysis with 8 microm phenylephrine + 1.7 microm 16,16-dimethyl-pge2 = 65 +/- 10 % of rate with 8 microm phenylephrine alone , n = 4 , p less than 0.05 ; 4.9 microm angiotensin ii + ... | NA | {
"id": "C0033559",
"name": "pge",
"pos": [
0,
3
]
} | {
"id": "C0012472",
"name": "pge2",
"pos": [
346,
350
]
} |
we conclude that a 1.6 kb polymorphism in the 5'-flanking region of the human insulin gene in both normal and niddm subjects has no association with insulin secretory responses as defined here by the glucose potentiation slope . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
72,
85
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
149,
156
]
} |
in vivo peripheral insulin action was measured using the euglycemic glucose clamp technique during an insulin infusion of 40 mu/m2 x min , with blood glucose clamped at a concentration of 75 mg/dl using a variable glucose infusion . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
144,
157
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
214,
221
]
} |
thus , a protein showing immunological cross-reaction with rat gst-p is also elevated during pancreatic carcinogenesis and hepatocarcinogenesis in the hamster , suggesting its usefulness as a marker with potential relevance to the mechanisms underlying the neoplastic process . | NA | {
"id": "C0596263",
"name": "carcinogenesis",
"pos": [
104,
118
]
} | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
257,
275
]
} |
macrophages stimulated by lentinan were cytotoxic in conjunction with igg1 , igg2a and igg3 mabs , but not with igg2b , igm , or iga mabs . | NA | {
"id": "C0003250",
"name": "mabs",
"pos": [
92,
96
]
} | {
"id": "C0003241",
"name": "mabs",
"pos": [
133,
137
]
} |
gel filtration analysis of the antigen indicated a molecular weight of greater than or equal to 1 x 10 ( 6 ) , and the antigenic determinant was suggested to be a carbohydrate chain with terminal sialic acid by studies using periodic acid , neuraminidase and pronase treatments . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
31,
38
]
} | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
119,
140
]
} |
early postoperative complications included anastomotic leaks ( 15 ) , cricopharyngeal incoordination with aspiration ( 6 ) , and gastric perforation ( 2 ) . | NA | {
"id": "C0032787",
"name": "postoperative complications",
"pos": [
6,
33
]
} | {
"id": "C0919691",
"name": "anastomotic leaks",
"pos": [
43,
60
]
} |
at concentrations approximating those in the colonic lumen , ampicillin , clindamycin , erythromycin , and lincomycin depressed tone and spontaneous contractions of the muscularis mucosae . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
74,
85
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
107,
117
]
} |
clindamycin , gentamicin , kanamycin , and lincomycin abolished electrically evoked contractions but only gentamicin and kanamycin could abolish the ensuing relaxation . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
0,
11
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
43,
53
]
} |
under the conditions of these experiments , gastric somatostatin inhibits basal gastrin release and directly inhibits pentagastrin-stimulated acid secretion without affecting gastrin release . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
118,
130
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
175,
182
]
} |
t3 caused an increase in tca-soluble radioactivity of cells that were incubated with [ 14c ] serine , [ 14c ] glycine or the nonmetabolizable amino acid [ 14c ] cycloleucine . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
110,
117
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
142,
152
]
} |
the order of relative potencies of the steroids tested were progesterone approximately equal to 17 alpha-hydroxy-20 beta-dihydroprogesterone greater than 17 alpha-hydroxy-20 alpha-dihydroprogesterone greater than 17 alpha-hydroxyprogesterone greater than 11-deoxycorticosterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
60,
72
]
} | {
"id": "C0012311",
"name": "alpha",
"pos": [
216,
221
]
} |
because they are involved in the tissue alterations of dupuytren 's disease the authors hope to clarify the different mechanisms of finger joint contracture . | NA | {
"id": "C0013312",
"name": "dupuytren 's disease",
"pos": [
55,
75
]
} | {
"id": "C0009917",
"name": "contracture",
"pos": [
145,
156
]
} |
microsomes were assayed for cytochrome p-450 , aryl hydrocarbon hydroxylase ( ahh ) , ethoxycoumarin o-deethylase ( ecd ) and epoxide hydrolase ( eh ) activities , and for metabolism of benzo [ a ] pyrene ( bap ) , cytosols were assayed for glutathione s-transferase ( gst ) activity . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
28,
44
]
} | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
47,
75
]
} |
microsomes were assayed for cytochrome p-450 , aryl hydrocarbon hydroxylase ( ahh ) , ethoxycoumarin o-deethylase ( ecd ) and epoxide hydrolase ( eh ) activities , and for metabolism of benzo [ a ] pyrene ( bap ) , cytosols were assayed for glutathione s-transferase ( gst ) activity . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
47,
75
]
} | {
"id": "C0000644",
"name": "ethoxycoumarin o-deethylase",
"pos": [
86,
113
]
} |
increases in cytochrome p-450 levels and significant increases in ahh , ecd , eh and gst activities occurred in the rats fed brussels sprouts . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
13,
29
]
} | {
"id": "C0003927",
"name": "ahh",
"pos": [
66,
69
]
} |
increases in cytochrome p-450 levels and significant increases in ahh , ecd , eh and gst activities occurred in the rats fed brussels sprouts . | NA | {
"id": "C0003927",
"name": "ahh",
"pos": [
66,
69
]
} | {
"id": "C0000644",
"name": "ecd",
"pos": [
72,
75
]
} |
the binding of 125i-labeled human growth hormone ( hgh ) to liver membranes from several different species was studied to determine the lactogenic or somatotropic hormone nature of the receptors . | NA | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
28,
48
]
} | {
"id": "C0037663",
"name": "somatotropic hormone",
"pos": [
150,
170
]
} |
although numerous case reports have established that silicone elicits a characteristic response in tissues , the varying tissue reactions to silicone gels , liquids , and elastomers ( rubber ) have not been emphasized . | NA | {
"id": "C0037114",
"name": "silicone",
"pos": [
53,
61
]
} | {
"id": "C0599034",
"name": "silicone gels",
"pos": [
141,
154
]
} |
pitfalls in the cytologic diagnosis of regressively changed lipoma , intramuscular lipoma , angiolipoma , hibernoma , and lipoblastoma , which may lead to an erroneous diagnosis of liposarcoma , are illustrated . | NA | {
"id": "C0023798",
"name": "lipoma",
"pos": [
60,
66
]
} | {
"id": "C1260965",
"name": "lipoblastoma",
"pos": [
122,
134
]
} |
the primary tumors and metastases from 30 patients with stage ii breast carcinoma treated with low- or standard-dose combination chemotherapy ( cyclophosphamide , methotrexate , 5-fluorouracil ) were studied by the immunoperoxidase technique for pregnancy-associated plasma protein a ( papp-a ) , pregnancy-specific beta... | NA | {
"id": "C0033002",
"name": "pregnancy-specific beta-1-glycoprotein",
"pos": [
297,
335
]
} | {
"id": "C0032974",
"name": "placental protein",
"pos": [
351,
368
]
} |
in contrast to the deactivation of chemotaxis achieved by preincubation of neutrophils with other chemotactic factors , prior exposure to 10 ( -6 ) m pf4 ( 59-70 ) for 2 min , or 20 min at 37 degrees , enhanced by 1.5- to 2-fold the chemotactic responses of neutrophils evoked by optimal concentrations of fmlp , c5fr , ... | NA | {
"id": "C0008013",
"name": "chemotactic factors",
"pos": [
98,
117
]
} | {
"id": "C0027229",
"name": "fmlp",
"pos": [
306,
310
]
} |
taken together , these data indicate the presence of several epitopes in the affinity-purified tb68 antigen . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
61,
69
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
100,
107
]
} |
the mice were pretreated orally with albumin extracts from seeds of jack fruit ( jackalbumin ) and subsequently immunized subcutaneously with jackalbumin mixed with ovalbumin ( oa ) and a synthetic adjuvant , muramyl dipeptide ( mdp ) . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
37,
44
]
} | {
"id": "C0029923",
"name": "ovalbumin",
"pos": [
165,
174
]
} |
the lambda gt11/l2/33 recombinant contained a 1.1-kilobase dna insert which hybridized to dna isolated from each of the 15 c. trachomatis serovars . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
5,
6
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
90,
93
]
} |
a number of the membrane proteins are exposed on the cell surface , since intact radiolabeled treponemes bound antibodies directed against these proteins . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
16,
33
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
145,
153
]
} |
these results accord with previous observations that , of the antigen present in the whole rye grass pollen extract , the components showing greatest immunogenicity in murine systems are not those commonly regarded as being the major allergens in man . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
62,
69
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
234,
243
]
} |
the antigen-presenting capability of macrophage modified with a single hapten ( dinitrofluorobenzene ) is partially or totally abolished by an additional haptenation with a second related ( picryl chloride ) or unrelated ( oxazolone ) hapten . | NA | {
"id": "C0031891",
"name": "picryl chloride",
"pos": [
190,
205
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
235,
241
]
} |
hapten responses which are controlled by different genes , e.g. , dinitrofluorobenzene , picryl chloride , and oxazolone on the one hand and benzilidene acetone on the other , do not compete . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
0,
6
]
} | {
"id": "C0031891",
"name": "picryl chloride",
"pos": [
89,
104
]
} |
in western blotting , several antigen molecules were seen , of which some were detected by all available antibodies , and one only with monoclonal antibody iii d5 , previously shown to react with mammary and ovarian carcinomas bearing estrogen receptors . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
105,
115
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
136,
155
]
} |
the ovarian cancer cells appeared to display the beta 1-pam constantly during culture , and enzymic treatment of the cells indicated that detection of the cell-bound antigen with antiserum could be , at least partially , eliminated with proteases but not glycosidases or neuraminidase . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
255,
267
]
} | {
"id": "C0027803",
"name": "neuraminidase",
"pos": [
271,
284
]
} |
in addition , spontaneous transformants , exhibiting morphology and growth patterns indistinguishable from those of tumor-dna-induced transfectants , neither contained transferred human dna sequences nor expressed cancer-related glycopeptides . | NA | {
"id": "C0012930",
"name": "tumor-dna",
"pos": [
116,
125
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
186,
189
]
} |
an immunofluorescence test using mb2 antibody showed that immunofluorescence-positive cells in non-producer md-lymphoblastoid line cells became detectable when the culture temperature was shifted from 41 degrees c to 33 degrees c or when treatment with 5-iodo-2-deoxyuridine ( iudr ) was performed , indicating that the ... | NA | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
262,
274
]
} | {
"id": "C0020811",
"name": "iudr",
"pos": [
277,
281
]
} |
we found that , whereas all 16 clones isolated from one tumor ( t-58 ) grew rapidly in vivo and in vitro , 10 clones isolated from the second tumor ( mt-2 ) showed a wide disparity in their growth rates in vivo . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
56,
61
]
} | {
"id": "C0085183",
"name": "second tumor",
"pos": [
135,
147
]
} |
transformed cells grow into colonies with relatively smooth edges , while normal fibroblasts form colonies with jagged edges , due to the protrusion of growing fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
12,
17
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
160,
171
]
} |
ifm recognized antibodies to htlv-i-related cellular antigens in addition to htlv-i viral antigens , but elisa recognized antibodies to htlv-i viral antigens alone . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
53,
61
]
} | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
143,
157
]
} |
ebv-specificity of the polypeptide was demonstrated by the presence of antibodies against this polypeptide in antisera from a population of ebv-seropositive donors , but not from seronegative donors , by the presence of the polypeptide itself in ebv-carrying but not in ebv-negative cell lines and by the appearance of a... | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
110,
118
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
319,
329
]
} |
rous sarcoma virus ( rsv ) -transformed chinese hamster fibroblasts , containing approximately ten copies of the dna domain comprising a single provirus and its flanking cellular sequences , were arrested in metaphase , and the chromosomes were fractionated by size in a sucrose gradient . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
56,
67
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
170,
178
]
} |
in order to explore the possible use of combining several hfl grafts from multiple donors , we studied immunological parameters as well as the in vitro responses of hfl cells from 20 fetuses , at 6 to 11 weeks of gestation , to allogeneic hfl cells and to adult lymphocytes in the mixed lymphocyte reaction ( mlr ) , and... | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
228,
238
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
363,
368
]
} |
it appears that hfl at 6 to 11 weeks of gestation lack immunocompetent cells capable of provoking positive mlr in response to allogeneic hfl cells or to adult lymphocytes , and also capable of inactivating hfl-derived hematopoietic stem cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
71,
76
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
126,
136
]
} |
it appears that hfl at 6 to 11 weeks of gestation lack immunocompetent cells capable of provoking positive mlr in response to allogeneic hfl cells or to adult lymphocytes , and also capable of inactivating hfl-derived hematopoietic stem cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
71,
76
]
} | {
"id": "C0018956",
"name": "hematopoietic stem cells",
"pos": [
218,
242
]
} |
after the elimination of a subpopulation of peripheral blood mononuclear cells ( pbmc ) that adhered to the histamine column , the response to mitogens of the unbound cells of normal control subjects was significantly lower than values obtained before separation . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
44,
78
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
155,
158
]
} |
axial sesamoid injury appeared to be an indication of severe fetlock trauma due to condylar fracture . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
69,
75
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
92,
100
]
} |
acute gastric zygomycosis ( mucormycosis ) was diagnosed in four 6- to 7-day-old pigs with large venous infarcts in the gastric fundus . | NA | {
"id": "C0043541",
"name": "zygomycosis",
"pos": [
14,
25
]
} | {
"id": "C0026718",
"name": "mucormycosis",
"pos": [
28,
40
]
} |
levels of serum lh , prolactin , testosterone , progesterone and 17-oh progesterone and the testicular concentration and total content of lh receptors were measured in 4- , 11- , 18- , and 27-month-old fisher 344 rats . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
48,
60
]
} | {
"id": "C0020387",
"name": "17-oh progesterone",
"pos": [
65,
83
]
} |
amplification of the antibiotic effects of the bleomycins , phleomycins and tallysomycins : its dependence on the nature of the variable basic groups . | NA | {
"id": "C0005740",
"name": "antibiotic",
"pos": [
21,
31
]
} | {
"id": "C0031559",
"name": "phleomycins",
"pos": [
60,
71
]
} |
in this paper a sample of 26 such compounds were tested for this property with 25 different phleomycins , bleomycins and tallysomycins . | NA | {
"id": "C0031559",
"name": "phleomycins",
"pos": [
92,
103
]
} | {
"id": "C0005740",
"name": "bleomycins",
"pos": [
106,
116
]
} |
the nature of the variable basic group of the phleomycins , bleomycins and tallysomycins determined the response obtained with all amplifiers , although variation of response was much less marked with caffeine which potentiated the cytotoxic effects of all the phleomycins , bleomycins and tallysomycins tested . | NA | {
"id": "C0031559",
"name": "phleomycins",
"pos": [
46,
57
]
} | {
"id": "C0005740",
"name": "bleomycins",
"pos": [
275,
285
]
} |
phleomycins and bleomycins having two or three guanidino groups in the variable basic group , or phleomycins having a secondary amino group within a methylene chain and a terminal 2-phenylethyl substituent , were amplified by most compounds , whereas the cytotoxicity of others was enhanced little or not at all . | NA | {
"id": "C0005740",
"name": "bleomycins",
"pos": [
16,
26
]
} | {
"id": "C0031559",
"name": "phleomycins",
"pos": [
97,
108
]
} |
bleomycins and phleomycins having identical basic groups were amplified to similar extents by the sample of 26 amplifying agents used . | NA | {
"id": "C0005740",
"name": "bleomycins",
"pos": [
0,
10
]
} | {
"id": "C0031559",
"name": "phleomycins",
"pos": [
15,
26
]
} |
these results suggest that labile maternal body protein reserves are used by gravid and nursing dams to fulfill reproductive needs and that dietary protein sequence affects the dam 's performance and body composition . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
48,
55
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
140,
155
]
} |
to determine the mics of eight macrolides and related agents ( erythromycin , spiramycin , oleandomycin , josamycin , midecamycin , lincomycin , clindamycin and pristinamycin ) for 36 strains of legionella , we used two charcoal-free media : buffered yeast extract agar and buffered antibiotic medium no . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
132,
142
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
145,
156
]
} |
with sulphamethoxazole , trimethoprim and co-trimoxazole the results were less satisfactory , especially with gram-negative rods , but agreement within two dilutions could be achieved . | NA | {
"id": "C0038689",
"name": "sulphamethoxazole",
"pos": [
5,
22
]
} | {
"id": "C0041044",
"name": "co-trimoxazole",
"pos": [
42,
56
]
} |
no important difference between latamoxef and its decarboxylated derivative was found , and the same observation was made for penicillin g and carbenicillin . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
126,
138
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
143,
156
]
} |
vesicles composed of the inner membrane and devoid of outer membrane and periplasmic proteins were able to transport iron supplied as ferric citrate and ferric parabactin . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
117,
121
]
} | {
"id": "C0060231",
"name": "ferric citrate",
"pos": [
134,
148
]
} |
since it appears that e. coli can translocate the same proteins either cotranslationally or posttranslationally , the cotranslational mode may perhaps be more efficient , but not obligatory , for the secretion of bacterial proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
55,
63
]
} | {
"id": "C0004627",
"name": "bacterial proteins",
"pos": [
213,
231
]
} |
the anionic frequency shift reagent , dysprosium ( iii ) tripolyphosphate , which does not permeate intact cells , when added to suspensions of intact adult rat cardiac myocytes , alters the nmr frequency of extracellular sodium ions , [ na+ ] o , leaving that of intracellular ions , [ na+ ] i , unaffected . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
4,
11
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
278,
282
]
} |
the anionic frequency shift reagent , dysprosium ( iii ) tripolyphosphate , which does not permeate intact cells , when added to suspensions of intact adult rat cardiac myocytes , alters the nmr frequency of extracellular sodium ions , [ na+ ] o , leaving that of intracellular ions , [ na+ ] i , unaffected . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
4,
11
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
293,
294
]
} |
the glycerophospholipids of the ciliate protozoan tetrahymena thermophila differ greatly in their content of alkylacylglycerol with phosphatidylcholine , phosphatidylethanolamine , and 2-aminoethylphosphonolipid containing 60 , 4 , and 53 % glyceryl ether , respectively . | NA | {
"id": "C0162448",
"name": "glycerophospholipids",
"pos": [
4,
24
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
132,
151
]
} |
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