text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the glycerophospholipids of the ciliate protozoan tetrahymena thermophila differ greatly in their content of alkylacylglycerol with phosphatidylcholine , phosphatidylethanolamine , and 2-aminoethylphosphonolipid containing 60 , 4 , and 53 % glyceryl ether , respectively . | NA | {
"id": "C0162448",
"name": "glycerophospholipids",
"pos": [
4,
24
]
} | {
"id": "C0031618",
"name": "phosphatidylethanolamine",
"pos": [
154,
178
]
} |
here , we examined the effects of a 20-kda cytokine derived from cultured epithelium on collagenase expression by normal human skin fibroblasts and by cells from recessive dystrophic epidermolysis bullosa , a disease characterized by over-production of a structurally altered collagenase . | NA | {
"id": "C0127082",
"name": "collagenase",
"pos": [
88,
99
]
} | {
"id": "C0162745",
"name": "collagenase",
"pos": [
276,
287
]
} |
treatment of cultures with steroid products , androstenedione or testosterone , or product analogs , epitestosterone or 17 alpha-methyltestosterone , at a concentration of 2 microm , which is equivalent to the concentration of testosterone resulting from stimulation with camp , also caused oxygen tension-sensitive decr... | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
101,
116
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
227,
239
]
} |
reductions in hydroxylase and lyase activities resulting from testosterone- or epitestosterone-treatment had little or no effect on acute camp-stimulated testosterone production , whereas desensitization with camp caused an 80-90 % reduction in steroidogenic capacity . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
79,
94
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
154,
166
]
} |
the store of factor v in normal platelets prevents an analogous determination of the functional factor va platelet binding sites . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
13,
21
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
96,
105
]
} |
lecithin : cholesterol acyltransferase activity was measured by the conversion of [ 4-14c ] cholesterol to [ 4-14c ] cholesteryl ester using artificial phospholipid/cholesterol/ [ 4-14c ] cholesterol/apoprotein substrates . | NA | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
117,
134
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
188,
199
]
} |
we fractionated mrna from fetal rat lung fibroblasts incubated in the presence or absence of dexamethasone and observed that cell-free translation products from a fraction of approximately 500 bases possess biological activity in the bioassay . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
41,
52
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
125,
129
]
} |
in the presence of the hydrolyzable nucleoside 5'-triphosphate , dttp , the half-life of the gene 4 protein-dna complex using circular m13 dna is at least 4 times longer than that observed using linear m13 dna . | NA | {
"id": "C0012925",
"name": "circular",
"pos": [
126,
134
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
206,
209
]
} |
although excessive storage of glucosylceramide in histiocytes is pathognomonic for gaucher disease , we found that gaucher disease fibroblasts contained 1.23 +/- 0.08 nmol of glucosylceramide/mg cell protein ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
131,
142
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
195,
199
]
} |
approximately 50 % homology between tnf and another cytolytic lymphokine , lymphotoxin , exists when the nh2-terminal 34 residues of tnf and internal sequence generated by tryptic , staphylococcus aureus v8 protease , and chymotryptic digests of tnf are aligned with the complete amino acid sequence of lymphotoxin . | NA | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
62,
72
]
} | {
"id": "C0024320",
"name": "lymphotoxin",
"pos": [
303,
314
]
} |
in contrast , cells maintained in the presence of medium a alone , once they reached confluence , formed a fibroblastic multilayer and produced thick collagen bundles . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
14,
19
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
107,
119
]
} |
a comprehensive peptide map of the oat phytochrome subunit is presented , which incorporates the results of these proteolytic studies with the recent , yet unpublished sequence analyses of avena phytochrome cdna clones which show the n-terminal localization of the chromophore binding site ( hershey , h. p. , colbert , ... | NA | {
"id": "C0250581",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0031857",
"name": "phytochrome",
"pos": [
195,
206
]
} |
5 s ribosomal rna in xenopus has been shown to be transcribed in vitro from 5 s rna genes that remain stably associated with required transcription factors through multiple rounds of transcription ( bogenhagen , d. f. , wormington , w. m. , and brown , d. d. ( 1982 ) cell 28 , 413-421 ) . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
4,
17
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
80,
83
]
} |
the relative binding affinity of the purified receptor was : ethynyl estradiol greater than 17 beta estradiol greater than estriol greater than or equal to estrone greater than or equal to 17 alpha-estradiol greater than mestranol . | NA | {
"id": "C0015011",
"name": "ethynyl estradiol",
"pos": [
61,
78
]
} | {
"id": "C0025506",
"name": "mestranol",
"pos": [
221,
230
]
} |
the sensitivity of the forskolin-stimulated cyclic amp response of rat fat cells to the adenosine agonist n6-phenylisopropyladenosine is amplified 3-fold by hypothyroidism . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
88,
97
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
109,
133
]
} |
hypothyroidism does not significantly alter the number of affinity of binding sites for n6-cyclohexyl [ 3h ] adenosine or n6-phenylisopropyladenosine in membranes of rat fat cells . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
109,
118
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
125,
149
]
} |
in the present study , we have used swainsonine , an indolizidine alkaloid , to modify the structure of n-glycosidically linked complex oligosaccharides . | NA | {
"id": "C0085535",
"name": "swainsonine",
"pos": [
36,
47
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
66,
74
]
} |
incubation of the partially purified enzyme with catecholamines such as dopamine , norepinephrine , and epinephrine resulted in a remarkable decrease in the enzyme activity , as assayed at a neutral ph . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
83,
97
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
104,
115
]
} |
the protein , which was found to be basic and a general dna binding protein , was insoluble at low ionic strength in the absence , but not in the presence , of dna . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0012940",
"name": "dna binding protein",
"pos": [
56,
75
]
} |
a dna fragment containing the coding sequence for the ompa signal peptide was initially ligated to a dna fragment containing the coding sequence for nuclease a , with a linker sequence of 33 nucleotides separating the coding sequences . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
0,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
101,
104
]
} |
use of 6-fluoroderivatives of pyridoxal and pyridoxal phosphate in the study of the coenzyme function in glycogen phosphorylase . | NA | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
44,
63
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
84,
92
]
} |
sedimentation equilibrium analyses in the presence of 6 m guandinium chloride , 10 mm ca2+ , 10 mm edta , or 0.15 m nacl all yielded a molecular weight of 29,100 +/- 900 . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
69,
77
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
116,
120
]
} |
discoidal substrates for purified human lecithin-cholesterol acyltransferase were prepared with human apolipoprotein a-i , cholesterol , and egg phosphatidylcholine ( pc ) or dipalmitoyl pc , including dihexadecyl pc in various proportions as an enzymatically inert dilutor of the interfacial pc substrate . | NA | {
"id": "C0000039",
"name": "dipalmitoyl pc",
"pos": [
175,
189
]
} | {
"id": "C1959616",
"name": "pc",
"pos": [
293,
295
]
} |
although cys 147 is an active site residue in histidine decarboxylase from lactobacillus 30a , the absence of a corresponding residue in the c. perfringens enzyme confirms previous indications ( recsei , p. a. , and snell , e. e. ( 1982 ) j. biol . chem . 257 , 7196-7202 ) that this sh group is not essential for decarb... | NA | {
"id": "C0019605",
"name": "histidine decarboxylase",
"pos": [
46,
69
]
} | {
"id": "C0007054",
"name": "decarboxylase",
"pos": [
314,
327
]
} |
after replacing intracellular chloride with sulfate and treating cells with the anion transport inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonate , exposure to valinomycin results in uptake of tetra [ 3h ] phenylphosphonium ion and stimulation of [ 9 , 10- ( 3 ) h ] oleic acid incorporation , but , because anion e... | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
30,
38
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
313,
318
]
} |
after replacing intracellular chloride with sulfate and treating cells with the anion transport inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonate , exposure to valinomycin results in uptake of tetra [ 3h ] phenylphosphonium ion and stimulation of [ 9 , 10- ( 3 ) h ] oleic acid incorporation , but , because anion e... | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
44,
51
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
313,
318
]
} |
after replacing intracellular chloride with sulfate and treating cells with the anion transport inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonate , exposure to valinomycin results in uptake of tetra [ 3h ] phenylphosphonium ion and stimulation of [ 9 , 10- ( 3 ) h ] oleic acid incorporation , but , because anion e... | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
82,
85
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
313,
318
]
} |
a preliminary epr investigation of iron accumulation in apoferritin has identified paramagnetic species generated during the early stage of iron deposition within the apoprotein shell . | NA | {
"id": "C0003590",
"name": "apoferritin",
"pos": [
56,
67
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
167,
177
]
} |
the association rate constants are similar to those measured for d-3-mercapto-2-methylpropanoyl-l-proline , captopril , but the dissociation rate constants are severalfold slower and account for the higher affinity of these inhibitors for the enzyme . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
98,
105
]
} | {
"id": "C0006938",
"name": "captopril",
"pos": [
108,
117
]
} |
it became sensitive to proteinase k , it exposed new antigenic epitopes in its ha1 chain , and it acquired amphiphilic properties , notably the ability to bind to liposomes . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
53,
62
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
63,
71
]
} |
technical issues such as limiting amounts of antibody or antigen , radioiodination of the ligands , unavailability of the epitopes for reaction with antibody , selective binding of apo-a-i isoforms , and individual allotypic differences in apo-a-i were not responsible for the observed incomplete binding of all hdl and ... | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
57,
64
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
122,
130
]
} |
the validity of this observed heterogeneity was supported by demonstrating that ( i ) increased binding of hdl occurred when each of the apo-a-i antibodies was combined to form an oligoclonal antibody mixture , and ( ii ) 100 % binding of hdl occurred when two apo-a-i antibodies were combined with the single apo-a-ii a... | NA | {
"id": "C0069426",
"name": "oligoclonal antibody",
"pos": [
180,
200
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
319,
327
]
} |
the relative abilities of insulin and the phorbol ester tumor promoter 12-o-tetradecanoyl phorbol 13-acetate ( tpa ) to lead to the phosphorylation of ribosomal protein s6 in vivo were compared in a reuber h35 hepatoma cell line shown previously to be highly responsive to these agents . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
42,
55
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl phorbol 13-acetate",
"pos": [
71,
108
]
} |
unstimulated human lung fibroblasts ( hfl-1 ) secreted timp at the rate of approximately 2 micrograms/10 ( 6 ) cells/24 h , and normal foreskin fibroblasts ( hs 27 ) and skin fibroblasts from a patient with hurler 's disease ( gm 1391 ) secreted timp at 0.3 and 0.2 micrograms/10 ( 6 ) cells/24 h , respectively . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
24,
35
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
286,
291
]
} |
to study the location of selenomethionine and methionine residues in the polypeptide chain of the enzyme , thiolase was prepared from cells cultured in the presence of h2 35so4 or na2 75seo3 . | NA | {
"id": "C0036584",
"name": "selenomethionine",
"pos": [
25,
41
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
46,
56
]
} |
the glycoprotein in the 5 m urea-extracted pellet has been solubilized by boiling in sodium dodecyl sulfate and purified to near-homogeneity by sequential steps of chromatography on hydroxylapatite and sephacryl s-300 ( both run in the presence of 0.1 % sodium dodecyl sulfate ) , followed by affinity chromatography on ... | NA | {
"id": "C0037506",
"name": "sodium dodecyl sulfate",
"pos": [
85,
107
]
} | {
"id": "C0058632",
"name": "dodecyl sulfate",
"pos": [
261,
276
]
} |
y-form dna is a competent , transient intermediate during the bidirectional replication of linear dna molecules and dna-binding protein is essential to initiate leftward synthesis . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
7,
10
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
166,
167
]
} |
the effects of cyclic nucleotides on elastin synthesis were studied in ligamentum nuchae fibroblasts by adding exogenous cyclic nucleotide derivatives or beta-adrenergic agents to cell culture medium . | NA | {
"id": "C0028631",
"name": "cyclic nucleotides",
"pos": [
15,
33
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
128,
138
]
} |
pretreatment of hepatocytes with phorbol ester ( pma ) or 1-oleoyl-2-acetylglycerol totally inhibited the effects of phenylephrine in elevating the cytosolic free ca2+ ; | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
33,
46
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
49,
52
]
} |
in the presence of datp , b. subtilis rec catalyzes dna strand transfer , assayed by the conversion of phi x174 linear duplex dna and homologous circular single-stranded dna to replicative form ii ( circular double-stranded dna with a discontinuity in one strand ) . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
154,
169
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
208,
227
]
} |
the acetylenic hydrogen shifts to the adjacent carbon and one atom of molecular oxygen is incorporated into the carboxylic acid group in these transformations , which are subject to a large kinetic isotope effect when the acetylenic hydrogen is replaced by deuterium . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
15,
23
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
257,
266
]
} |
it also inhibited egf binding to bovine corneal endothelial cells , rabbit corneal fibroblasts , human foreskin fibroblasts , and normal rat kidney cells , and it slightly enchanced egf binding to sw 3t3 cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
83,
94
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
130,
136
]
} |
151-igg by itself possessed intrinsic egf-like activity for human fibroblasts but not for the other cells tested . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
66,
77
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
100,
105
]
} |
acidic amino acids predominate over basic amino acids , as shown both by the amino acid composition of the enzyme and an isoelectric point for nitrate reductase of 5.7 . | NA | {
"id": "C0815040",
"name": "acidic amino acids",
"pos": [
0,
18
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
77,
87
]
} |
acidic amino acids predominate over basic amino acids , as shown both by the amino acid composition of the enzyme and an isoelectric point for nitrate reductase of 5.7 . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
36,
53
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
77,
87
]
} |
c-reactive protein ( crp ) is an acute phase reactant which humoral concentration rises drastically following tissue injury or inflammation . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
0,
18
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
33,
53
]
} |
further experiments using fab fragments prepared from pure igg to each apolipoprotein showed that binding of radioiodinated hdl to cells was suppressed following preincubation of hdl with fab fragments raised against apolipoproteins ai or aii but not against apolipoproteins e or ciii-1 or albumin . | NA | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
71,
85
]
} | {
"id": "C0003595",
"name": "apolipoproteins e",
"pos": [
259,
276
]
} |
thin needles are obtained in the presence of a monovalent cation ( na+ ) , thicker crystals are obtained in the presence of divalent cations ( mg2+ , mn2+ , fe2+ , ca2+ , zn2+ ) , and square-faced crystals are obtained in the presence of spermine . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
58,
64
]
} | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
124,
140
]
} |
liver mitochondria bound heart mitochondria mt-ck to the same extent as creatine kinase-depleted heart mitochondria . mt-ck was bound by liposomes but only if they contained cardiolipin . | NA | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
72,
87
]
} | {
"id": "C0914594",
"name": "mt-ck",
"pos": [
118,
123
]
} |
the tumor-promoting phorbol ester 12-o-tetradecanoyl phorbol 13-acetate ( tpa ) was found to induce the biosynthesis and deposition of two cytoskeletal components in the human erythroleukemic cell line k562 with apparent mr = 55,000 and 46,000 . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
20,
33
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl phorbol 13-acetate",
"pos": [
34,
71
]
} |
because n-nitrosodiethylamine requires enzymatic activation to form the ultimate carcinogen , it is suggested that the observed inhibition of nitrosamine-transforming enzymes in the liver during dsf treatment leads to an increased amount of intact nitrosamines in other organs , e.g. , in the esophagus , where it could ... | NA | {
"id": "C0012200",
"name": "n-nitrosodiethylamine",
"pos": [
8,
29
]
} | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
248,
260
]
} |
the mixture of cef tropomyosin has been isolated by the combination of triton/glycerol extraction of monolayer cells , heat treatment , and ammonium sulfate fractionation . | NA | {
"id": "C0016030",
"name": "cef",
"pos": [
15,
18
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
111,
116
]
} |
analysis of the altered keratin patterns on two-dimensional acrylamide gels using either isoelectric focusing ( ief ) or non-equilibrium ph gradient electrophoresis ( nephg ) along the first dimension showed that the infected cells produced basic keratins which increased in relative abundance as cells became more trans... | NA | {
"id": "C0010803",
"name": "keratin",
"pos": [
24,
31
]
} | {
"id": "C1179973",
"name": "basic keratins",
"pos": [
241,
255
]
} |
a one-step chromatographic procedure was used to isolate rapidly mouse igg monoclonal antibodies ( mabs ) ( igg1 , igg2a , igg2b ) contained in ascites fluids and fab fragments contained in papain-treated mab suspensions . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
86,
96
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
205,
208
]
} |
the insulin products resulting from today 's technology include highly purified isolates from bovine or porcine pancreas and insulin that is identical in structure to human insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
4,
11
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
167,
180
]
} |
a study of the effects of temperature on the separation of the components in insulin injectables led to the development of a reversed-phase high performance liquid chromatographic ( hplc ) method that uses a sulfate buffer/acetonitrile mobile phase at 40 degrees c for the separation and quantitation of bovine , porcine... | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
77,
84
]
} | {
"id": "C0795635",
"name": "human insulins",
"pos": [
327,
341
]
} |
albumins isolated from normal sera and sera of patients with fdh displayed multiple protein bands , with isoelectric points between 4.65 and 5.75 , and protein patterns were the same in the two groups . | NA | {
"id": "C0001924",
"name": "albumins",
"pos": [
0,
8
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
152,
159
]
} |
excretion of the o-methyl derivative of ne normetanephrine was increased ( p less than 0.01 ) in the aged , whereas excretion of the deaminated metabolites vanillylmandelic acid and dihydroxmandelic acid was decreased . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
40,
42
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
43,
58
]
} |
patients given human menopausal gonadotropin and clomiphene citrate had significantly higher levels of plasma prl compared to those given clomiphene only . | NA | {
"id": "C0546859",
"name": "clomiphene citrate",
"pos": [
49,
67
]
} | {
"id": "C0009008",
"name": "clomiphene",
"pos": [
138,
148
]
} |
to determine whether exogenous glucocorticoids modulate this pulsatility and to study its possible etiological implications , we obtained 24-h plasma cortisol profiles in seven patients with cushing 's syndrome ( five cushing 's disease , one adrenal adenoma , and one bilateral adrenal cortical macronodular hyperplasia... | NA | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
191,
210
]
} | {
"id": "C0001622",
"name": "cushing 's disease",
"pos": [
218,
236
]
} |
when plasma glucose was allowed to decline precipitously from hyperglycemic levels ( 220 mg/dl ) to nadirs ranging from 42-77 mg/dl , plasma concentrations of glucagon , cortisol , epinephrine , and norepinephrine all increased ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
181,
192
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
199,
213
]
} |
antepartum lipoprotein lipid and apoprotein concentrations were generally not different in the 2 groups , with the single exception of whole plasma and low density lipoprotein ( ldl ) apoprotein ( apo ) b ( probably a chance difference ) . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
11,
22
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
23,
28
]
} |
it is concluded that 1 ) in md patients , serum dhas and dha concentrations are significantly lower than those in normal subjects , explaining the frequent reports of low or low normal 17-ks excretion ; | NA | {
"id": "C0057277",
"name": "dhas",
"pos": [
48,
52
]
} | {
"id": "C0011185",
"name": "concentrations",
"pos": [
61,
75
]
} |
2 ) the reduced dhas and dha concentrations are most likely due to decreased production rather than increased clearance ; | NA | {
"id": "C0057277",
"name": "dhas",
"pos": [
16,
20
]
} | {
"id": "C0011185",
"name": "concentrations",
"pos": [
29,
43
]
} |
in order to evaluate whether 1,25-dihydroxyvitamin d3 [ 1,25 ( oh ) 2d3 ] could increase the serum concentration of osteocalcin ( bgp ) in patients with post-menopausal osteoporosis , we administered 2 micrograms/d of 1,25 ( oh ) 2d3 to 14 patients with biopsy proven osteoporosis for two weeks . | NA | {
"id": "C0029458",
"name": "post-menopausal osteoporosis",
"pos": [
153,
181
]
} | {
"id": "C0029456",
"name": "osteoporosis",
"pos": [
268,
280
]
} |
components of the total serum thyroid hormone concentrations during pregnancy : high free thyroxine and blunted thyrotropin ( tsh ) response to tsh-releasing hormone in the first trimester . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
68,
77
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
173,
188
]
} |
amobarbital has been found to coelute with 25-hydroxycholecalciferol ( 25ohd3 ) on a normal phase high performance liquid chromatographic system and cause subsequent interference in the uv detection and plasma transport competitive protein binding assay for this vitamin d metabolite . | NA | {
"id": "C0006657",
"name": "25-hydroxycholecalciferol",
"pos": [
43,
68
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
71,
77
]
} |
16k fragments 2-36 , gamma 3msh , alpha msh , beta-endorphin , leu-enkephalin , and met-enkephalin , as well as hcg , fsh , prostaglandin e2 , prostaglandin f2 alpha , epinephrine , and norepinephrine did not stimulate adenylate cyclase activity in either zone . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
168,
179
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
186,
200
]
} |
changes in plasma progesterone and 17-hydroxyprogesterone over 30 min were summed and expressed as a combined rate of rise . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
18,
30
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
35,
57
]
} |
six of 9 hla-b14-positive individuals had a rate of rise greater than 2 sd above the mean control value . | NA | {
"id": "C0062817",
"name": "hla-b14",
"pos": [
9,
16
]
} | {
"id": "C0019737",
"name": "2",
"pos": [
70,
71
]
} |
after separation by acidic gel filtration , the samples were assayed for igf using a protein-binding assay ( which measures mainly igf i-related peptides ) and for igf bp by measuring the binding activity , in both assays using igf i as tracer . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
73,
76
]
} | {
"id": "C0021665",
"name": "igf i",
"pos": [
228,
233
]
} |
nonetheless , megakaryocyte factor v was more slowly activated by thrombin and in the absence of calcium was more stable after activation than was plasma factor va . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
28,
36
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
154,
163
]
} |
in confirmation of previous findings , the binding and degradation of 125i-ldl by human fibroblasts were inhibited approximately 90 % by antibodies 2a or 2b or the antigen-binding fragments of 2a , whereas the cellular processing of 125i-vldl3 ( sf20-60 ) , 125i-vldl2 ( sf60-120 ) , and 125i-vldl1 ( sf greater than 120... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
88,
99
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
210,
218
]
} |
deoxyadenosine has been implicated as the toxic metabolite causing profound lymphopenia in immunodeficient children with a genetic deficiency of adenosine deaminase ( ada ) , and in adults treated with the potent ada inhibitor deoxycoformycin . | NA | {
"id": "C0024312",
"name": "lymphopenia",
"pos": [
76,
87
]
} | {
"id": "C0021051",
"name": "immunodeficient",
"pos": [
91,
106
]
} |
plasminogen activator complexes were formed by reacting the streptokinases with human plasminogen in vitro and the clearance studied in mice . | NA | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
0,
21
]
} | {
"id": "C0038418",
"name": "streptokinases",
"pos": [
60,
74
]
} |
in other studies , we have established that heme oxygenase blockade by sn-protoporphyrin leads to a marked and rapid excretion of heme into bile presumably because the synthetic metabolism to bile pigment and making it available for excretion via the biliary system in to the gut , these studies strongly suggest that sn... | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
178,
188
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
233,
242
]
} |
dna from the human myeloid cell line hl-60 was cotransfected with the cloned thymidine kinase ( tk ) gene of herpes simplex virus into tk-deficient mouse l cells . tk-positive recipients expressing antigens detected on hl-60 cells were isolated with a fluorescence-activated cell sorter by use of a panel of monoclonal a... | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
198,
206
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
342,
350
]
} |
independently sorted populations of transformed mouse cells showed concordant reactivities with four of the monoclonal antibodies in the panel ( du-hl60-4 , my7 , mcs.2 , and sj-d1 ) , which suggested that these antibodies reacted to products of a single human gene . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
108,
129
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
212,
222
]
} |
a second round of dna transfection and cell sorting was performed with donor dna from primary transformants . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
77,
80
]
} |
the reduced cholesterol and apo b levels were associated with increased fcrs ( 0.68 +/- 0.29 d-1 ) and reduced cholesterol/protein ratios ( 1.01 +/- 0.18 ) in ldl . | NA | {
"id": "C0003601",
"name": "apo b",
"pos": [
28,
33
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
123,
130
]
} |
elastase activity was increased and porcine tropoelastin was degraded four times faster , on a per-cell basis , in lesional fibroblast cultures than in cells derived from an unaffected site . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
124,
134
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
152,
157
]
} |
these results suggest that the clonogenic cells are a distinct subpopulation in all cases of aml , and may be derived from normal hematopoietic progenitor cells at multiple points in the differentiation pathway . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
42,
47
]
} | {
"id": "C0018956",
"name": "hematopoietic progenitor cells",
"pos": [
130,
160
]
} |
c reactive protein ( crp ) and serum amyloid a protein ( saa ) are sensitive and rapid acute phase reactants , and their measurement for monitoring inflammatory disease and assessing the prognosis in secondary amyloidosis is gaining widespread acceptance . | NA | {
"id": "C0006560",
"name": "c reactive protein",
"pos": [
0,
18
]
} | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
87,
108
]
} |
c reactive protein ( crp ) and serum amyloid a protein ( saa ) are sensitive and rapid acute phase reactants , and their measurement for monitoring inflammatory disease and assessing the prognosis in secondary amyloidosis is gaining widespread acceptance . | NA | {
"id": "C0002723",
"name": "saa",
"pos": [
57,
60
]
} | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
87,
108
]
} |
these observations suggest that caution is required in the interpretation of estimations of saa concentration and that it may be too sensitive an acute phase protein for clinical use as its concentration may be raised in both trivial and asymptomatic viral infections . | NA | {
"id": "C0002723",
"name": "saa",
"pos": [
92,
95
]
} | {
"id": "C0001347",
"name": "acute phase protein",
"pos": [
146,
165
]
} |
( b ) inhibit host defense mechanisms including leukotoxin , a polymorphonuclear leukocyte chemotaxis inhibiting factor , and a lymphocyte suppressing factor ( c ) cause tissue destruction such as lipopolysaccharide endotoxin , a bone resorption-inducing toxin , acid and alkaline phosphatases , collagenase , a fibrobla... | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
197,
215
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
216,
225
]
} |
the aim of the present study was to investigate the rate of development of experimentally-induced gingival inflammation in relation to the susceptibility to periodontal disease . | NA | {
"id": "C0017574",
"name": "gingival inflammation",
"pos": [
98,
119
]
} | {
"id": "C0017563",
"name": "periodontal disease",
"pos": [
157,
176
]
} |
the results clearly show that our relatively old patients with juvenile periodontitis had a completely different microflora in their periodontally diseased regions than patients with common periodontitis . | NA | {
"id": "C0031106",
"name": "juvenile periodontitis",
"pos": [
63,
85
]
} | {
"id": "C0031099",
"name": "periodontitis",
"pos": [
190,
203
]
} |
bioequivalence comparisons between erythromycin ethylsuccinate and an enteric-coated erythromycin base pellet product were made following multiple-dose , oral administration . | NA | {
"id": "C0014810",
"name": "erythromycin ethylsuccinate",
"pos": [
35,
62
]
} | {
"id": "C0014806",
"name": "erythromycin base",
"pos": [
85,
102
]
} |
amyloid plaques were demonstrable in central nervous system tissues of adult captive mule deer affected with chronic wasting disease , a transmissible primary spongiform encephalopathy . | NA | {
"id": "C1135993",
"name": "chronic wasting disease",
"pos": [
109,
132
]
} | {
"id": "C0162534",
"name": "transmissible",
"pos": [
137,
150
]
} |
subchondral fractures in association with an intact joint space and narrowing of the joint space have not previously been reported with sacroiliac joint trauma in children . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
12,
21
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
153,
159
]
} |
the presence of this substance helped to identify nevus cells in dense inflammatory infiltrates and confirm the histologic diagnosis of halo nevus . | NA | {
"id": "C0027960",
"name": "nevus",
"pos": [
50,
55
]
} | {
"id": "C0474824",
"name": "halo nevus",
"pos": [
136,
146
]
} |
the enamel biopsy data showed that the fluoride uptake resulting from 0.2 % naf alone was not statistically significant , whereas uptake produced by the dcpd-forming plus naf rinses was significant . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
39,
47
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
171,
174
]
} |
while there was variation between the test organisms , freshly isolated strains were generally more fluoride-tolerant than were the type strains , and a group of seven strains would grow well at ph 4.5 with 5.3 mm naf . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
100,
108
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
214,
217
]
} |
a comparison with fluoride compounds demonstrated that al was equivalent to snf2 and more effective than naf and na2po3f . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
18,
26
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
105,
108
]
} |
in this way , various arthroses , tumors , cysts , fractures , true ankylosis , neoplasias , developmental abnormalities , and other bony abnormalities can be clearly found . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
34,
40
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
43,
48
]
} |
one hundred consecutive patients hospitalized in the coronary care unit for unstable angina , excluding patients with prinzmetal 's variant angina , were randomized within 24 hours of admission to treatment with diltiazem ( 50 patients ) or propranolol ( 50 patients ) . | NA | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
76,
91
]
} | {
"id": "C0002963",
"name": "prinzmetal 's variant angina",
"pos": [
118,
146
]
} |
this similar result observed with the two forms of treatment suggests that coronary artery spasm may not be the main factor involved in unstable angina when prinzmetal 's variant angina is excluded . | NA | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
136,
151
]
} | {
"id": "C0002963",
"name": "prinzmetal 's variant angina",
"pos": [
157,
185
]
} |
in conclusion , computed tomography is of great help in differentiating this syndrome from other diseases such as mediastinal mass or lymphadenopathy whenever hoarseness is complicated by pulmonary hypertension . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
77,
85
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
97,
105
]
} |
to determine whether histamine sensitivity also contributes to allergen responsiveness , 893 subjects in a rural community were prick tested with 14 allergens and tenfold dilutions of histamine phosphate beginning at 1 mg/ml-1 . | NA | {
"id": "C0019588",
"name": "histamine",
"pos": [
21,
30
]
} | {
"id": "C0062740",
"name": "histamine phosphate",
"pos": [
184,
203
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.