text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
we also studied the effects on cellular glucocorticoid receptor number and affinity when tao at a concentration of 4 x 10 ( -5 ) alone , at 10 ( -5 ) m in combination with a receptor saturating concentration of mp ( 5 x 10 ( -8 ) m ) , with mp alone , or with oleo ( 10 ( -5 ) m ) combined with mp was added to fibroblas... | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
31,
39
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
311,
322
]
} |
this is also true for the other major processes involved with the biological fate of both xenobiotics and nutrients , such as distribution , metabolism , and excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
141,
151
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
158,
167
]
} |
plasma epinephrine ( epi ) and norepinephrine ( ne ) levels were examined among healthy men aged 20 to 25 and 60 to 65 years basally and during epi infusions . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
31,
45
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
144,
147
]
} |
plasma ne levels were elevated among the elderly men , but both age groups had an increase in ne during the epi 42.9 ng/kg/min infusion rate . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
7,
9
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
108,
111
]
} |
using horseradish peroxidase ( hrp ) -conjugated anti-mouse ( sub ) class ( igg2a , igg2b , igm ) antibodies and anti-rabbit class ( igg , igm ) antibodies and a double immunocytochemical staining technique for simultaneous demonstration of the enzymes ap and hrp , we were able to determine both the antigen specificity... | NA | {
"id": "C0021017",
"name": "class",
"pos": [
68,
73
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
407,
415
]
} |
an antiserum to gamma-aminobutyric acid ( gaba ) was tested for the localization of gabaergic neurons in the central nervous system using the unlabeled antibody enzyme method under pre- and postembedding conditions . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
3,
12
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
152,
160
]
} |
this hypothesis is supported by the observation that a monoclonal antibody to the t cell receptor will inhibit both responses , although the response to mls-locus-disparate stimulators appears to be more sensitive to these antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
55,
74
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
223,
233
]
} |
administration of an optimal dose of dextran 2 hours before applying picryl chloride to abdominal skin caused a twofold rise in the level of hapten-specific dth . | NA | {
"id": "C0031891",
"name": "picryl chloride",
"pos": [
69,
84
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
141,
147
]
} |
when these anti-asgm1-treated mice were immunized with allogeneic cells , they showed neither augmented nk activity nor generation of alloimmune ctl , and spleen cells isolated from these anti-asgm1-treated mice produced no ctl response to alloimmunization in vitro . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
55,
71
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
162,
167
]
} |
normal spleen cells treated with the antiserum and complement in vitro also showed a complete nk depletion without any deterioration of t cells and their lyt-1 and lyt-2 subsets , and when stimulated with allogeneic cells they generated no ctl . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
0,
6
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
205,
221
]
} |
when these purified asgm1+ thy-1- cells were stimulated with allogeneic cells , they produced il 2 and ifn . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
34,
39
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
61,
77
]
} |
activation of lyt-2+ picryl chloride ( pc1 ) -specific cloned t cell lines by trinitrophenyl ( tnp ) -coupled spleen cells results in proliferation and the production of at least two lymphokines : lymphotoxin ( lt ) and ifn-gamma . | NA | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
183,
194
]
} | {
"id": "C0024320",
"name": "lymphotoxin",
"pos": [
197,
208
]
} |
monocytes or macrophages may be induced to produce il 1 by activators ( e.g. , lipopolysaccharide endotoxin ) that act directly or by antigens/mitogens ( e.g. , con a ) that stimulate inducer lymphocytes to release a lymphokine that stimulates macrophages . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
79,
97
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
98,
107
]
} |
glycosphingolipids purified from organic extracts of these cells were analyzed to seek information concerning the chemical basis for these surface antigenic differences , to assess the structural and antigenic diversity of pmn and hl-60 glycolipids , and to quantitate chemically and antigenically prominent glycolipids ... | NA | {
"id": "C0017978",
"name": "glycosphingolipids",
"pos": [
0,
18
]
} | {
"id": "C0017950",
"name": "glycolipids",
"pos": [
308,
319
]
} |
in vivo and in vitro studies of the binding of antibody/dsdna immune complexes to rabbit and guinea pig platelets . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
47,
55
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
62,
78
]
} |
when monocytes in monolayers were preincubated with 100 micrograms/ml of beta-glucan and then incubated with 1.25 to 2.5 x 10 ( 6 ) zymosan particles , the percentage of cells that exhibited phagocytosis was inhibited in a time-dependent manner ; | NA | {
"id": "C1134651",
"name": "beta-glucan",
"pos": [
73,
84
]
} | {
"id": "C0043552",
"name": "zymosan",
"pos": [
132,
139
]
} |
maximal inhibition occurred within 20 min of preincubation . beta-glucan inhibited monocyte phagocytosis of zymosan and rabbit erythrocytes ( er ) in a similar dose-dependent fashion and at 100 micrograms/ml reduced monocyte ingestion of 5 x 10 ( 6 ) /ml zymosan and 2 x 10 ( 8 ) /ml er by 63 +/- 8 % and 68 +/- 16 % ( m... | NA | {
"id": "C1134651",
"name": "beta-glucan",
"pos": [
61,
72
]
} | {
"id": "C0043552",
"name": "zymosan",
"pos": [
255,
262
]
} |
thus , the monocyte receptor for particulate activators that is specifically inhibited by beta-glucan at a rate compatible with a phagocytic process and that recognizes beta-glucans but not alpha-glucans , mannan , or galactan is a beta-glucan receptor . | NA | {
"id": "C1134651",
"name": "beta-glucans",
"pos": [
169,
181
]
} | {
"id": "C0017696",
"name": "glucans",
"pos": [
196,
203
]
} |
we report that despite comparable rates of c3 and lysozyme synthesis and similar processing and kinetics of secretion of c2 and factor b , the freshly isolated tissue macrophage differs from the monocyte-derived macrophage in the proportion of c2-producing cells , in the average single-cell production rate of complemen... | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
311,
321
]
} | {
"id": "C0033453",
"name": "factor b",
"pos": [
362,
370
]
} |
a meningococcal group b-specific horse antiserum contains at least two distinct populations of antibodies with specificities for determinants on the group b capsular polysaccharide antigen . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
39,
48
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
95,
105
]
} |
furthermore , prior exposure of t cells to high concentrations of spa led to the generation of an antigen-dependent population of cells capable of suppressing the anti-spa response when co-cultured with autologous pbmc and optimal spa concentrations . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
34,
39
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
214,
218
]
} |
this system should serve as an effective tool for analyzing the cellular interactions involved in the in vitro regulation of antigen-specific antibody synthesis by human pbmc . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
64,
72
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
170,
174
]
} |
the meaning of this special prominence of the igg4 antibody response to filarial infection is not yet clear , but the question of whether these antibodies play a role in immediate hypersensitivity reactions as either reagins or blocking antibodies is being investigated for its potential pathogenetic significance . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
144,
154
]
} | {
"id": "C0034761",
"name": "reagins",
"pos": [
217,
224
]
} |
previous molecular analyses of monoclonal idcr+ ars-binding antibodies isolated from multiply immunized animals have indicated that these antibody variable ( v ) regions may be the expressed product of a single combination of vh , d , jh , v kappa , and j kappa gene segments . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
31,
41
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
138,
146
]
} |
the type of cytotoxic effector cells that eradicates the tumor depends on tumor antigenicity : lowly antigenic tumors are attacked mainly by macrophages , whereas large highly antigenic tumors can be eradicated by cytotoxic t lymphocytes only . | NA | {
"id": "C0003335",
"name": "antigenic",
"pos": [
80,
89
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
176,
185
]
} |
we have examined the effect of tumor-promoting phorbol esters such as phorbol myristate acetate ( pma ) on the murine b cell leukemia bcl-1 and its in vitro adapted derivative cw.13.20 . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
47,
61
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
70,
77
]
} |
phorbol esters , including pma and phorbol dibutyrate ( pdbu ) , were potent inhibitors of bcl-1 igm secretion induced by either lps or lymphokines ; | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
0,
14
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
27,
30
]
} |
this doubly analytical technique permits simultaneous study of antibody specificity by immunoprecipitation and characterisation of antibody isotypes by immuno-filtration with enzyme-labelled antibodies . | NA | {
"id": "C0021017",
"name": "antibody isotypes",
"pos": [
131,
148
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
191,
201
]
} |
the selection of antibodies with defined desorption properties from precipitated immune complexes for use in immunoadsorption procedures . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
17,
27
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
81,
97
]
} |
very low concentrations of antibodies ( 8-30 ng/ml ) could be detected in antisera with the specifically sensitized rbc as reagents in passive hemagglutination with no or very low non-specific agglutination . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
27,
37
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
74,
82
]
} |
both the arotinoid and the aromatic retinoid persisted for longer in the epidermis than equivalent doses of ra or 13-cis-ra . | NA | {
"id": "C0035339",
"name": "retinoid",
"pos": [
36,
44
]
} | {
"id": "C0022265",
"name": "13-cis-ra",
"pos": [
114,
123
]
} |
the fastest migrating species was single minus-strand dna , and the five slower species all were double-stranded relaxed circular dna . | NA | {
"id": "C0012935",
"name": "single",
"pos": [
34,
40
]
} | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
97,
112
]
} |
an appropriate quantity of fatty acid is necessary for human spermatozoa to penetrate into zona-free hamster eggs , because penetration rates were low in the percentage of fatty acid free albumin regardless of the concentration added . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
27,
37
]
} | {
"id": "C0015688",
"name": "fatty acid free",
"pos": [
172,
187
]
} |
putrescine and spermidine in the plasma , and putrescine and spermine in the urine were elevated during pregnancy . | NA | {
"id": "C0037871",
"name": "plasma",
"pos": [
33,
39
]
} | {
"id": "C0034170",
"name": "putrescine",
"pos": [
46,
56
]
} |
putrescine and spermidine in the plasma , and putrescine and spermine in the urine were elevated during pregnancy . | NA | {
"id": "C0037871",
"name": "plasma",
"pos": [
33,
39
]
} | {
"id": "C0037874",
"name": "urine",
"pos": [
77,
82
]
} |
corrected albumin spaces are 2.95 and 2.83 microliter/mg cell protein with and without rose bengal , respectively . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
10,
17
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
62,
69
]
} |
it can not be used for quantitation of hbf or for quantitation of hemoglobins that comigrate with hba ; | NA | {
"id": "C0015936",
"name": "hbf",
"pos": [
39,
42
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
66,
77
]
} |
it can not be used for quantitation of hbf or for quantitation of hemoglobins that comigrate with hba ; | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
66,
77
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
98,
101
]
} |
contrariwise , it can be used for hemoglobins that only separate from hba on agar ( e.g. , hbbethesda ) . | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
34,
45
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
70,
73
]
} |
synthesis of fibrinogen in these same perfusions was characteristic of the known acute-phase reactant proteins . | NA | {
"id": "C0016006",
"name": "fibrinogen",
"pos": [
13,
23
]
} | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
81,
92
]
} |
human peripheral blood monocytes were incubated with free or liposome-encapsulated human lymphokines containing macrophage-activating factor ( maf ) and tested for their effect on herpes simplex virus ( hsv ) -infected target cells . | NA | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
89,
100
]
} | {
"id": "C0079786",
"name": "macrophage-activating factor",
"pos": [
112,
140
]
} |
this may be because intracellular apoproteins may be unassociated with lipoproteins , or they could be associated with lipoproteins in various stages of assembly of protein with lipids . | NA | {
"id": "C0003601",
"name": "apoproteins",
"pos": [
34,
45
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
165,
172
]
} |
this may be because intracellular apoproteins may be unassociated with lipoproteins , or they could be associated with lipoproteins in various stages of assembly of protein with lipids . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
71,
83
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
178,
184
]
} |
serum factor was also required to restore pg synthesis after aspirin-inactivation in other cells , including 3t3 mouse fibroblasts , sv40-3t3 and k-balb 3t3 transformed mouse fibroblasts , nrk rat kidney cells , and ref-9 rat embryonic fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
91,
96
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
236,
247
]
} |
with recycled serum-free perfusate , as opposed to serum-containing medium , there was hepatic reuptake of nascent vldl , indicated by the reuptake of newly synthesized apoe and all three forms of apob , and not other apolipoproteins . | NA | {
"id": "C0003595",
"name": "apoe",
"pos": [
169,
173
]
} | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
218,
233
]
} |
with recycled serum-free perfusate , as opposed to serum-containing medium , there was hepatic reuptake of nascent vldl , indicated by the reuptake of newly synthesized apoe and all three forms of apob , and not other apolipoproteins . | NA | {
"id": "C0003593",
"name": "apob",
"pos": [
197,
201
]
} | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
218,
233
]
} |
compared to the c-ldl , the ch-ldl were smaller in size , depleted of cholesteryl ester and phospholipid , and had a marked decrease in their cholesterol : protein ratio . | NA | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
70,
87
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
142,
153
]
} |
in dmem , cells adopted a fibroblast-like appearance with a doubling time of 34 h while in ham 's f12 , cells retained an epithelial-like morphology with a doubling time of 91 h . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
26,
36
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
104,
109
]
} |
no differences were detected between the two groups of women , suggesting that the administration of mpa during pregnancy did not alter qualitatively or quantitatively the metabolism and excretion into urine of progesterone and oestrogens . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
172,
182
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
187,
196
]
} |
production of factor b was modulated by treatment of macrophages in vivo or in culture with bacterial lipopolysaccharide endotoxin , which increased the synthesis , secretion , and accumulation of factor b up to 11-fold . | NA | {
"id": "C0014264",
"name": "bacterial",
"pos": [
92,
101
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
102,
120
]
} |
moreover , it does not appear to be a contaminating endotoxin , since lps neither conditioned am for roi production , nor triggered roi production by serum-conditioned am . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
52,
61
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
70,
73
]
} |
as inositol trisphosphate appears to function as such a signal for certain hormone receptors , we measured the levels of inositol trisphosphate and of the other inositol phosphate compounds in jurkat . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
3,
11
]
} | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
161,
179
]
} |
group a consisted of six different monoclonal antibodies that recognized antigens on the colony-forming unit-megakaryocyte ( cfu-mk ) , in vitro grown colony megakaryocytes , and early immature marrow megakaryocytes , only , and did not detect their respective epitopes on either mature megakaryocytes or platelets . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
73,
81
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
261,
269
]
} |
it was found that absorption of the anti-h-2 antisera removed all of the antibody reactive with lymphocytes , but only about half of the antibody reactive with embryos . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
45,
53
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
137,
145
]
} |
it is suggested that some of this nuclear rna may be stable small nuclear rnas ( e.g . u1 rna ) retained from the germinal vesicle stage through meiotic maturation . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
34,
45
]
} | {
"id": "C0035709",
"name": "small nuclear rnas",
"pos": [
60,
78
]
} |
during the 2-cell stage and beyond , maternal rna is degraded and labeled precursor is reincorporated into nuclear rna , making it difficult to accurately quantitate the amount of nuclear maternal rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
41,
44
]
} | {
"id": "C0035700",
"name": "nuclear",
"pos": [
180,
187
]
} |
we also analysed dna from rat embryo cells transformed by ts mutants of hsv-2 ( hg52 ) or hsv-1 ( hfem or 17 ) at non-permissive temperature or by virus at supraoptimal temperature or by sheared virus dna and dna from tumours derived from lines of these transformed cells . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
17,
20
]
} | {
"id": "C0012930",
"name": "dna",
"pos": [
209,
212
]
} |
both open reading frames are initiated by aug codons in sequence contexts that are relatively infrequently used as initiator codons . | NA | {
"id": "C0009221",
"name": "codons",
"pos": [
46,
52
]
} | {
"id": "C0242610",
"name": "initiator codons",
"pos": [
115,
131
]
} |
an eia carried out by the antibody-capture technique , using antiserum specific for `` '' enteric '' '' adenoviruses [ johansson et al , 1979 ] , gave positive results with all isolates that could be propagated only in 293 cells and with none of those capable of growing in hep2 cells . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
26,
34
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
61,
70
]
} |
immunoblot experiments indicated that the 51k/6.0 protein stained with antiserum to glial fibrillary acidic protein ( gfap ) and the 57k/5.7 protein stained with antibodies to vimentin . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
71,
80
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
162,
172
]
} |
these experiments suggest that the membrane receptors present on astroglia function , in part , to regulate phosphorylation of the intermediate filament proteins gfap and vimentin . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
131,
161
]
} | {
"id": "C0017626",
"name": "gfap",
"pos": [
162,
166
]
} |
these experiments suggest that the membrane receptors present on astroglia function , in part , to regulate phosphorylation of the intermediate filament proteins gfap and vimentin . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
131,
161
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
171,
179
]
} |
the effect of nerve stimulation on inositol phospholipid hydrolysis in autonomic tissue was assessed by direct measurement of [ 3h ] inositol phosphate production in ganglia that had been preincubated with [ 3h ] inositol . | NA | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
133,
151
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
213,
221
]
} |
l-5-hydroxytryptophan ( l-5-htp ) ( 20 or 200 mg/kg i.p . ) but not l-tryptophan ( 500 mg/kg i.p . ) loading substantially increases serum melatonin in sheep . | NA | {
"id": "C0000578",
"name": "l-5-hydroxytryptophan",
"pos": [
0,
21
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
70,
80
]
} |
the butyrophenone neuroleptics spiroperidol , benperidol , and haloperidol were radiolabeled with fluorine-18 and studied in baboon brain using positron emission transaxial tomography ( pett ) . | NA | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
4,
17
]
} | {
"id": "C0037956",
"name": "spiroperidol",
"pos": [
31,
43
]
} |
the butyrophenone neuroleptics spiroperidol , benperidol , and haloperidol were radiolabeled with fluorine-18 and studied in baboon brain using positron emission transaxial tomography ( pett ) . | NA | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
4,
17
]
} | {
"id": "C0005013",
"name": "benperidol",
"pos": [
46,
56
]
} |
animals treated with high doses of amphetamines have been used as a model of schizophrenia due to the similarities between the psychosis associated with this mental disorder and that induced by chronic amphetamine abuse . | NA | {
"id": "C0002667",
"name": "amphetamines",
"pos": [
35,
47
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
202,
213
]
} |
incorporation of [ 3h ] glucosamine precursor into gags was higher for hs ( 56 % of incorporated precursor ) and lower for ha ( 29 % ) and cs ( 15 % ) . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
51,
55
]
} | {
"id": "C0019143",
"name": "hs",
"pos": [
71,
73
]
} |
the major constituents of gags were chondroitin sulfate ( cs ) , hyaluronic acid ( ha ) , and heparan sulfate ( hs ) . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
26,
30
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
94,
109
]
} |
the incorporation of [ 3h ] glucosamine into individual gags was highest for hs at postnatal day 6 , whereas ha showed intermediate and cs the lowest levels of incorporation during the first postnatal week . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
56,
60
]
} | {
"id": "C0019143",
"name": "hs",
"pos": [
77,
79
]
} |
male icr mice , young ( 25-days old ) , mature ( 3-months old ) , and old ( 22 months ) , were injected with morphine sulfate ( 10 mg/kg , s.c. ) or were implanted with morphine pellets ( 75 mg ) . | NA | {
"id": "C0066814",
"name": "morphine sulfate",
"pos": [
109,
125
]
} | {
"id": "C0026549",
"name": "morphine",
"pos": [
169,
177
]
} |
the present studies measure the transport of retinol , retinoic acid , 1,25-dihydroxyvitamin d3 [ 1,25- ( oh ) 2d3 ] , and 25-hydroxyvitamin d3 [ 25- ( oh ) d3 ] through the rat brain capillary endothelial wall , i.e. , the blood-brain barrier ( bbb ) . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
123,
143
]
} | {
"id": "C2713074",
"name": "25",
"pos": [
146,
148
]
} |
antisera against the indolealkylamines : tryptophan , 5-hydroxytryptophan , 5-hydroxytryptamine , 5-methoxytryptophan , and 5-methoxytryptamine tested by an enzyme-linked immunosorbent assay method . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
41,
51
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
54,
73
]
} |
antisera against the indolealkylamines : tryptophan , 5-hydroxytryptophan , 5-hydroxytryptamine , 5-methoxytryptophan , and 5-methoxytryptamine tested by an enzyme-linked immunosorbent assay method . | NA | {
"id": "C0036751",
"name": "5-hydroxytryptamine",
"pos": [
76,
95
]
} | {
"id": "C0000589",
"name": "5-methoxytryptamine",
"pos": [
124,
143
]
} |
antisera were raised against tryptophan , 5-hydroxytryptophan , 5-hydroxytryptamine , 5-methoxytryptophan , and 5-methoxytryptamine , by conjugating each molecule to bovine serum albumin and to human serum albumin via glutaraldehyde , in such a way as to preserve the original part . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
29,
39
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
42,
61
]
} |
antisera were raised against tryptophan , 5-hydroxytryptophan , 5-hydroxytryptamine , 5-methoxytryptophan , and 5-methoxytryptamine , by conjugating each molecule to bovine serum albumin and to human serum albumin via glutaraldehyde , in such a way as to preserve the original part . | NA | {
"id": "C0036751",
"name": "5-hydroxytryptamine",
"pos": [
64,
83
]
} | {
"id": "C0000589",
"name": "5-methoxytryptamine",
"pos": [
112,
131
]
} |
in the boyden method , marked inhibition of chemotaxis ( p less than .01 ) was caused by bcnu , vinblastine , vincristine , daunorubicin , and doxorubicin . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
124,
136
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
143,
154
]
} |
the rank-order of potency of several adrenergic agonists in potentiating the effect of vip on camp levels is the following : epinephrine greater than ne greater than phenylephrine much greater than clonidine , with ec50 of 2.2 , 5 , and 10 microm , respectively ( clonidine being only marginally effective ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
125,
136
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
271,
273
]
} |
we utilized 3h- [ d-ala2 , d-leu5 ] enkephalin ( dadl ) in the presence of 10 nm dago to label delta sites and 3h-ethylketocyclazocine ( ekc ) in the presence of 100 nm dadl + 100 nm [ d-ala2 , mephe4 , met ( 0 ) ol5 ] enkephalin to detect kappa receptors . | NA | {
"id": "C0525773",
"name": "dago",
"pos": [
81,
85
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
219,
229
]
} |
in adult rats with a unilateral 6-hydroxydopamine-induced destruction of the nigrostriatal dopamine ( da ) pathway , grafts of embryonic substantia nigra can establish a new dopaminergic terminal fiber plexus in the previously denervated neostriatum and compensate for some of the behavioral deficits induced by the nigr... | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
41,
49
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
174,
186
]
} |
the ki values for cyclohexyladenosine , ( + ) - and ( - ) -phenylisopropyladenosine , 2-chloroadenosine , and adenosine 5'-ethylcarboxamide were 0.8 , 0.9 , 2.6 , 12 , and 54 microm , respectively . | NA | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
59,
83
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
110,
119
]
} |
the ki values for cyclohexyladenosine , ( + ) - and ( - ) -phenylisopropyladenosine , 2-chloroadenosine , and adenosine 5'-ethylcarboxamide were 0.8 , 0.9 , 2.6 , 12 , and 54 microm , respectively . | NA | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
86,
103
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
110,
119
]
} |
immunostaining of proenkephalin-derived opioid peptides , [ leu5 ] enkephalin and bovine adrenal medullary peptide-22p , was concentrated in cell bodies of the entorhinal cortex , nerve fibers in the perforant pathway , and terminals in the outer molecular layer of the dentate gyrus . | NA | {
"id": "C0205753",
"name": "opioid",
"pos": [
40,
46
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
67,
77
]
} |
these preliminary findings indicate that with pet studies it may be possible to prospectively differentiate patients with neurological deficits due to reversible ischemia from patients with irreversible infarction . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
162,
170
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
203,
213
]
} |
in five dogs the plasma concentrations of dopamine , epinephrine , and norepinephrine increased from 234 +/- 98 to 1906 +/- 1384 , 609 +/- 641 to 19,813 +/- 10,234 , and 388 +/- 194 to 3223 +/- 992 pg/ml , respectively ( all p less than 0.01 ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
53,
64
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
71,
85
]
} |
adrenoleukodystrophy is an x-linked disorder characterized by adrenal insufficiency and progressive demyelination of the cerebral white matter . | NA | {
"id": "C0162309",
"name": "adrenoleukodystrophy",
"pos": [
0,
20
]
} | {
"id": "C0001623",
"name": "adrenal",
"pos": [
62,
69
]
} |
after 6 wk of feeding , the rats were killed , and the tissues were processed for trace element , lipid and lipoprotein analysis . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
98,
103
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
108,
119
]
} |
hence , the effects of n intake and the iaa : daa ratio on kinetic aspects of whole-body alanine and glycine metabolism were examined in eight healthy young adult male subjects . | NA | {
"id": "C0002520",
"name": "daa",
"pos": [
46,
49
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
89,
96
]
} |
over 200 human aortic and coronary atherosclerotic plaques from 102 human necropsy subjects aged between 5 and 88 were , therefore , examined histologically for the presence of insoluble lipid ( ceroid ) , thought to be a product of lipid oxidation . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
187,
192
]
} | {
"id": "C0007831",
"name": "ceroid",
"pos": [
195,
201
]
} |
among 339,868 newborn infants screened at 3 weeks of age ( 91 % compliance rate ) , 730 had elevated rates of excretion of cystine and the dibasic amino acids lysine , ornithine , and arginine ; | NA | {
"id": "C0010682",
"name": "cystine",
"pos": [
123,
130
]
} | {
"id": "C0002523",
"name": "dibasic amino acids",
"pos": [
139,
158
]
} |
initially , each excreted cystine and dibasic amino acids at much higher levels than did normal infants or either parent . | NA | {
"id": "C0010682",
"name": "cystine",
"pos": [
26,
33
]
} | {
"id": "C0002523",
"name": "dibasic amino acids",
"pos": [
38,
57
]
} |
basal acid output , pentagastrin-stimulated acid output , fasting serum gastrin , and fasting serum pancreatic polypeptide were measured during each study . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
20,
32
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
72,
79
]
} |
it was low after simple febrile convulsions ( no cases of epilepsy in 230 children ) but considerable after complex febrile seizures ( 20 % ) or seizures associated with severe interictal eeg abnormalities ( 50 % ) . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
58,
66
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
145,
153
]
} |
epileptic children receiving polytherapy ( cbz associated with one or more of the following drugs : phenobarbital , primidone , phenytoin , ethosuximide ) had significantly different cbz clearance values and percent cbz-epox than did patients given cbz alone . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
100,
113
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
116,
125
]
} |
in vitro , the psychoactive cannabinoids , delta 9-tetrahydrocannabinol ( delta 9-thc ) and 11-hydroxyl-delta 9-tetrahydrocannabinol ( 11-oh-delta 9-thc ) at concentrations of 1 and 3 microm decreased polarization of the fluorescence emission of 1,6-diphenyl-1,3,5-hexatriene ( dph ) in spm . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
28,
40
]
} | {
"id": "C0039663",
"name": "delta 9-thc",
"pos": [
141,
152
]
} |
at the same concentrations , cannabidiol ( cbd ) and cannabinol , cannabinoids devoid of marijuana-like psychoactivity , had no effect on dph polarization . | NA | {
"id": "C0006865",
"name": "cannabinol",
"pos": [
53,
63
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
66,
78
]
} |
these findings indicate that the psychoactive cannabinoids increase fluidity in the hydrophobic core of brain membranes and support a membrane perturbant hypothesis of the mechanism of delta 9-thc action . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
46,
58
]
} | {
"id": "C0039663",
"name": "delta 9-thc",
"pos": [
185,
196
]
} |
a series of polymers bearing hydroxamic acid-terminated side chains were prepared for the purpose of developing new iron chelators for treating iron overload in beta-thalassemia ( cooley 's anemia ) and other iron diseases . | NA | {
"id": "C0282193",
"name": "iron",
"pos": [
116,
120
]
} | {
"id": "C0012715",
"name": "iron diseases",
"pos": [
209,
222
]
} |
this difference was relatively much smaller than the difference in phenobarbital concentrations observed in a similar preceding study , which is consistent with the different mechanisms of action of alcohols and barbiturates . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
67,
80
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
212,
224
]
} |
the results suggest that the specificity of experimental models of epilepsy used in the evaluation of potential antiepileptic drugs is primarily due to the intensity rather than the nature of the stimulus used or the kind of seizure component evoked . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
67,
75
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
225,
232
]
} |
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