text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the compound also blocked ovalbumin-induced release of slow reacting substance of anaphylaxis ( leukotrienes ) from guinea-pig lung . | NA | {
"id": "C0038091",
"name": "of slow reacting substance",
"pos": [
52,
78
]
} | {
"id": "C0023545",
"name": "leukotrienes",
"pos": [
96,
108
]
} |
significant elevations of arterial plasma norepinephrine , epinephrine and dopamine occurred after t-2 , with metabolic acidosis , hypocarbia and hyperoxemia in both conscious rats and guinea pigs . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
42,
56
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
59,
70
]
} |
both conditions can manifest with headache , facial pain radiating to the ear and the maxillary teeth , preauricular pain , and pain in the buccal vestibule posterior and superior to the maxillary tuberosity . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
34,
42
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
128,
132
]
} |
by using cell-type-specific markers and neural cultures derived from various areas of the nervous system , it has been possible to identify various interactions between oc43 virus and mouse oligodendrocytes , neurons , astrocytes , and fibroblasts . | NA | {
"id": "C0007634",
"name": "cell-type",
"pos": [
9,
18
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
236,
247
]
} |
further structural analyses of gp98 were performed by using the glycosidases endo-beta-n-acetylglucosaminidase h ( endoglycosidase h ) and neuraminidase and two inhibitors of glycosylation ( tunicamycin and monensin ) . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
64,
76
]
} | {
"id": "C0027803",
"name": "neuraminidase",
"pos": [
139,
152
]
} |
avian-human reassortant influenza a viruses containing only the nucleoprotein or matrix protein rna segment from the avian influenza virus parent were as restricted in their growth as an avian-human influenza reassortant virus containing each of the six avian influenza internal genes . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
64,
77
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
88,
95
]
} |
this was done by ligating the psti a and b dna fragments from either tsa1499 or wt830 and transfecting the ligated dna into bsc-1h monkey kidney cells . | NA | {
"id": "C0919262",
"name": "b dna",
"pos": [
41,
46
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
115,
118
]
} |
anchorage-independent growth is highly correlated with neoplastic growth in vivo , and the retinoids ( vitamin a and its analogs ) inhibit this property in a wide variety of oncogenically transformed cells . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
91,
100
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
103,
112
]
} |
in particular , the nuclease activity was monitored by the extent of conversion of supercoiled closed duplex dna ( dna i ) to nicked circular dna ( dna ii ) , which could subsequently be converted to duplex linear dna ( dna iii ) by prolonged incubation with the enzyme . | NA | {
"id": "C0012937",
"name": "supercoiled",
"pos": [
83,
94
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
133,
145
]
} |
in particular , the nuclease activity was monitored by the extent of conversion of supercoiled closed duplex dna ( dna i ) to nicked circular dna ( dna ii ) , which could subsequently be converted to duplex linear dna ( dna iii ) by prolonged incubation with the enzyme . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
133,
145
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
220,
223
]
} |
two antibodies , mab rv-3:1 and mab rv-3:2 , reacted with the seven serotype 3 rotaviruses only . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
32,
35
]
} |
the antibody mab rv-3:3 was specific for an epitope of rv-3 rotavirus not present on any other rotavirus of any serotype tested , including another neonatal isolate of identical rna electropherotype isolated from the same ward of the same hospital as rv-3 3 months earlier . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
4,
12
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
13,
16
]
} |
the virions were rapidly linked by antibody into oligomers and larger aggregates , followed by slow redistribution of antibody between the immune complexes . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
35,
43
]
} | {
"id": "C0003313",
"name": "immune",
"pos": [
139,
145
]
} |
cdna-rna hybridization confirmed the banding of viral rna at each density , and immune electron microscopy demonstrated apparently complete viral particles in each peak fraction . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
5,
8
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
48,
57
]
} |
the giant cell tumor was composed of multinucleated giant and mononuclear stromal cells , and was morphologically indistinguishable from giant cell tumor of the bone . | NA | {
"id": "C0017525",
"name": "giant cell tumor",
"pos": [
4,
20
]
} | {
"id": "C0206638",
"name": "giant cell tumor of the bone",
"pos": [
137,
165
]
} |
five enzymes have been assayed : 1 ) 5 alpha-reductase , 2 ) 3 alpha-hydroxysteroid oxidoreductase , 3 ) 3 beta-hydroxysteroid oxidoreductase , 4 ) 17 beta-hydroxysteroid oxidoreductase and 5 ) acid phosphatase . | NA | {
"id": "C0048751",
"name": "3",
"pos": [
61,
62
]
} | {
"id": "C0000413",
"name": "3 beta-hydroxysteroid oxidoreductase",
"pos": [
105,
141
]
} |
the following observations were made when comparing individual enzymatic activities between the 3 tissue groups : 1 ) mean 5 alpha-reductase activity was lower in carcinoma than in both normal prostate and bph ( p less than 0.05 ) , 2 ) mean 3 alpha-hydroxysteroid oxidoreductase and 3 beta-hydroxysteroid oxidoreductase... | NA | {
"id": "C0020392",
"name": "hydroxysteroid oxidoreductase",
"pos": [
250,
279
]
} | {
"id": "C0000413",
"name": "3 beta-hydroxysteroid oxidoreductase",
"pos": [
284,
320
]
} |
seven cases of acquired immunodeficiency syndrome ( aids ) and aids-related complex ( arc ) associated with human t-cell leukemia ( lymphotropic ) virus ( htlv ) -iii infection were documented in married males whose family members consented to medical evaluation . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
52,
56
]
} | {
"id": "C0019693",
"name": "htlv",
"pos": [
155,
159
]
} |
we suggest that patients with retinal vascular abnormalities , macular degeneration , ocular hypertension , glaucoma , and similar disorders refrain from inversion altogether . | NA | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
86,
105
]
} | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
108,
116
]
} |
with the mm cells , hyperthermia potentiated the cytotoxic effects of doxorubicin ( adm ) , daunorubicin , mitoxantrone ( dhad ) , and quelamycin but did not enhance that of aclacinomycin ( acm ) . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
70,
81
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
92,
104
]
} |
although immunoperoxidase staining provided important qualitative information regarding the distribution of antigen and antibody within the tumor , these studies demonstrated the usefulness of immunofluorescent flow cytometry for quantitative assessment of antibody localization in solid tumors and provided information ... | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
120,
128
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
366,
387
]
} |
although immunoperoxidase staining provided important qualitative information regarding the distribution of antigen and antibody within the tumor , these studies demonstrated the usefulness of immunofluorescent flow cytometry for quantitative assessment of antibody localization in solid tumors and provided information ... | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
120,
128
]
} | {
"id": "C0243020",
"name": "immunoconjugates",
"pos": [
392,
408
]
} |
the antibody reacted with squamous cell carcinomas , small cell carcinomas , adenocarcinomas , ductal carcinomas , and anaplastic carcinomas from gastrointestinal , lung , and breast tissues . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
77,
92
]
} | {
"id": "C1176475",
"name": "ductal",
"pos": [
95,
101
]
} |
virgin female rats of the sd strain were fed ad libitum a nutritionally adequate semipurified diet and demineralized water ( groups 1 and 2 ) , or the same diet with 10 ppm molybdenum ( group 3 ) or 150 ppm tungsten ( group 4 ) added to the drinking water . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
117,
122
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
241,
255
]
} |
tumor-promoting abilities of four barbiturates , phenobarbital [ ( pb ) cas : 50-06-6 ] , amobarbital [ ( ab ) cas : 57-43-2 ] , barbital sodium [ ( bb ) cas : 144-02-5 ] , and barbituric acid [ ( ba ) cas : 67-52-7 ] , on the development of neoplasms in livers and other organs of rats following initiation with n-nitro... | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
34,
46
]
} | {
"id": "C0002640",
"name": "amobarbital",
"pos": [
90,
101
]
} |
tdf induced the degenerative changes in human kb cells , hela cells , fl cells , and plc/prf/5 cells but not in human widr cells or in fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
49,
54
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
135,
146
]
} |
spectra from inclusions of macrophages indicated the presence of the elements sulfur , phosphorus , aluminum , silicon , and iron . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
69,
77
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
87,
97
]
} |
[ lactate dehydrogenase enzymes and isoenzymes in the diagnosis of forms of acute and postoperative pancreatitis ] . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
24,
31
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
36,
46
]
} |
both groups of mothers had supplemental intake of 5 mg vitamin b6 beginning with the 2nd trimester of gestation but not during lactation . | NA | {
"id": "C0032980",
"name": "2nd trimester",
"pos": [
85,
98
]
} | {
"id": "C0032961",
"name": "gestation",
"pos": [
102,
111
]
} |
in all 16 patients with severe iit , including three patients with thyroid storm , hormone levels decreased within a few days after surgery to normal or subnormal values and the clinical picture of thyrotoxicosis disappeared . | NA | {
"id": "C0040127",
"name": "thyroid storm",
"pos": [
67,
80
]
} | {
"id": "C0040156",
"name": "thyrotoxicosis",
"pos": [
198,
212
]
} |
an endogenous humoral factor which inhibits the sodium- and potassium-activated adenosine triphosphatase ( na-k-atpase ) enzyme in vitro has been incriminated recently of playing a pathogenetic role in experimental and human hypertension . | NA | {
"id": "C0001473",
"name": "adenosine triphosphatase",
"pos": [
80,
104
]
} | {
"id": "C0001479",
"name": "na-k-atpase",
"pos": [
107,
118
]
} |
lower levels of free plasma catecholamines , noradrenaline and adrenaline were recently described in statically trained athletes under identical work loads during incremental cycling as compared with untrained control subjects . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
45,
58
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
63,
73
]
} |
before exercise , the levels of conjugated plasma dopamine ( p less than 0.10 ) , of conjugated noradrenaline ( p less than 0.001 ) and conjugated adrenaline ( p less than 0.10 ) are 2-3 times lower in statically trained athletes than those of the control subjects . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
96,
109
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
147,
157
]
} |
by thin-layer and gas liquid chromatography lipids ( total lipids , phospholipids , cholesterol and its esters , nonesterified fatty acids , triglycerides ) and higher fatty acids were identified . | NA | {
"id": "C0015688",
"name": "nonesterified fatty acids",
"pos": [
113,
138
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
168,
179
]
} |
since the serum levels of the acute phase reactants , haptoglobin and amyloid-related serum protein aa , were higher in the group of patients with reactive amyloidosis than in patients with ssa , the depression of the prealbumin levels in ssa is not a result of inflammation . | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
30,
51
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
54,
65
]
} |
although the shift in sedimentation properties of receptor complexes at 2 degrees c is induced by rnase a , and not by other low molecular weight basic proteins or rnase t1 , the effect can be also obtained by inactive rnase a . | NA | {
"id": "C0018364",
"name": "rnase t1",
"pos": [
164,
172
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
219,
224
]
} |
the levels of norepinephrine , epinephrine , dopamine , adenosine triphosphate , and p-creatine were measured in whole mouse brain collected under two conditions : 1 ) the decapitated head was immediately plunged into liquid nitrogen ( nonanoxic tissue ) ; | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
14,
28
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
31,
42
]
} |
although the maximum protein handling capacity differs for the two apparatuses , this capacity is so limited that it disallows the use of albumin in the perfusate . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
21,
28
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
138,
145
]
} |
by excretory metabolism , we mean metabolism of a compound by an organ with direct excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
13,
23
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
83,
92
]
} |
there is a growing body of evidence that apoproteins of the high density lipoproteins ( hdl ) exchange between lipoprotein particles through the aqueous phase and that there is always a finite but physiologically important quantity of lipid-free apoprotein in plasma . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
73,
84
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
235,
240
]
} |
examination of these skin fibroblasts during the egta treatment by scanning electron microscopy reveals that ( a ) asc+ cells detach much more rapidly than asc- cells , but ( b ) asc- or asc+ cells leave the same two types of structures in longterm culture-generated substratum-attached material ( l-sam ) -- long linear... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
26,
37
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
192,
197
]
} |
placental homogenates showed large increases in mono-oxygenase enzymes , including aryl hydrocarbon hydroxylase , 7-ethoxycoumarin o-de-ethylase , and diol , quinone , and phenolic metabolites of benzo ( a ) pyrene ( analysed by high performance liquid chromatography ) . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
83,
111
]
} | {
"id": "C0000644",
"name": "7-ethoxycoumarin o-de-ethylase",
"pos": [
114,
144
]
} |
the pancreatic cholera syndrome is a serious and potentially fatal disease found in patients with endocrine pancreatic tumours and ganglioneuromas . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
23,
31
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
67,
74
]
} |
such changes were compatible with labyrinthine hydrops , or meniere 's disease , otosclerosis , and sensorineural hearing loss and vestibular dysfunction . | NA | {
"id": "C0206586",
"name": "labyrinthine hydrops",
"pos": [
34,
54
]
} | {
"id": "C0025281",
"name": "meniere 's disease",
"pos": [
60,
78
]
} |
precancerous conditions are type a gastritis , status after surgery of the stomach , hyperplasiogenic polyps of the stomach , increased familiar incidence of carcinoma , menetrier 's disease , and acanthosis nigricans . | NA | {
"id": "C0017152",
"name": "gastritis",
"pos": [
35,
44
]
} | {
"id": "C0017155",
"name": "menetrier 's disease",
"pos": [
170,
190
]
} |
in rats given desoxycorticosterone ( doc ) , the recently reported finding that a normal amount of dietary sodium chloride ( nacl ) induces hypertension but an equimolar amount of sodium bicarbonate ( nahco3 ) does not , might be a consequence of the differing effects of the two sodium salts on the metabolism of calciu... | NA | {
"id": "C0206136",
"name": "dietary sodium chloride",
"pos": [
99,
122
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
125,
129
]
} |
cck-octapeptide ( cck-8 ) ( ec50 = 0.5 nm ) , in the presence of li+ , increased 3h-inositol phosphate ( ip ) accumulation in guinea pig gastric glands prelabeled with 3h-inositol . | NA | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
84,
102
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
171,
179
]
} |
taurine , phosphoethanolamine , aspartic acid , glutamic acid , alanine , cystine , tyrosine , beta-alanine and ethanolamine were increased during the period of stress ; | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
64,
71
]
} | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
95,
107
]
} |
we also found that calcium reduced enzyme stimulation by forskolin and the gtp analog , guanyl 5'-yl imidodiphosphate [ gmp-p ( nh ) p ] in a dose-related manner and that activation by naf was less sensitive to inhibition by calcium . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
75,
78
]
} | {
"id": "C0018366",
"name": "guanyl 5",
"pos": [
88,
96
]
} |
ka produces seizures which eventually result in neuronal damage similar to that found in epilepsy . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
12,
20
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
89,
97
]
} |
mobile phase compositions for three different purposes are reported : 1 ) separation of 9 endogenous catechols , possibly occurring in the samples , and 3 i.s . in a moderately short retention time ( tr ) ( l-dopa , dopeg , alpha-methyldopa ( alpha-medopa , i.s . ) , noradrenaline ( na ) , dopac , adrenaline ( a ) , di... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
271,
281
]
} | {
"id": "C0028351",
"name": "na",
"pos": [
731,
733
]
} |
of these 31 patients , 15 ( 48 % ) had infection restricted to their skin , 6 ( 19 % ) appeared to have primary cutaneous infection that spread hematogenously to other parts of the body , 2 ( 6 % ) had infections of adjoining nasal tissue that spread to contiguous skin , and 8 ( 26 % ) appeared to have disseminated sys... | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
39,
48
]
} | {
"id": "C0243026",
"name": "systemic infection",
"pos": [
317,
335
]
} |
effect of exercise training on glucose tolerance , in vivo insulin sensitivity , lipid and lipoprotein concentrations in middle-aged men with mild hypertriglyceridemia . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
81,
86
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
91,
102
]
} |
the effects of 9 weeks of aerobic exercise training with maintenance of stable body weight upon insulin sensitivity and upon glucose , lipid , and lipoprotein concentrations were studied in 10 middle-aged men with mild hypertriglyceridemia . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
135,
140
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
147,
158
]
} |
to determine whether the rapid lipolytic effect observed with human growth hormone ( hgh ) preparations in rabbits and rabbit adipose tissue is an intrinsic property of the hormone , we examined the lipolytic effects in vivo and in vitro of clinical grade preparations , hgh purified by deae cellulose chromatography , a... | NA | {
"id": "C0037663",
"name": "human growth",
"pos": [
62,
74
]
} | {
"id": "C0169964",
"name": "hgh",
"pos": [
323,
326
]
} |
using isolated rabbit perirenal adipocytes , acth and clinical-grade hgh preparations both stimulated glycerol release to the same maximal rate with half-maximal hgh effects observed between 8 and 50 micrograms/ml . | NA | {
"id": "C0037663",
"name": "hgh preparations",
"pos": [
69,
85
]
} | {
"id": "C0169964",
"name": "hgh",
"pos": [
162,
165
]
} |
purification of the most potent lipolytic preparation of clinical grade hgh by deae cellulose chromatography yielded a preparation ( 2 iu/mg of growth activity that retained insulinlike effects on rat fat pad [ u-14c ] glucose metabolism ) that , at concentrations up to 0.2 mg/ml , failed to stimulate lipolysis by adip... | NA | {
"id": "C0037663",
"name": "preparation",
"pos": [
42,
53
]
} | {
"id": "C0169964",
"name": "hgh",
"pos": [
482,
485
]
} |
rapid lipolytic stimulation in rabbit adipocytes by hgh preparations could not be attributed to the 20,000 molecular weight variant of hgh ( hgh20k ) or the peptide corresponding to positions 32 to 46 of hgh ( deletion peptide ) . | NA | {
"id": "C0037663",
"name": "hgh preparations",
"pos": [
52,
68
]
} | {
"id": "C0169964",
"name": "hgh",
"pos": [
204,
207
]
} |
the microsomal fraction was also incubated in vitro and the appearance of [ 3h ] -25-hydroxyvitamin d3 [ 25 ( oh ) d3 ] was determined by high performance liquid chromatography ( hplc ) . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
82,
102
]
} | {
"id": "C2713074",
"name": "25 ( oh ) d3",
"pos": [
105,
117
]
} |
carcinoid tumors , which contain tryptophan hydroxylase , secrete serotonin , and pheochromocytomas , which contain tyrosine hydroxylase , may secrete dopamine ( da ) , norepinephrine ( ne ) , or epinephrine ( e ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
169,
183
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
196,
207
]
} |
forearm extraction of 3h-ne and of endogenous plasma epinephrine decreased significantly during hypoglycemia , probably due to an increase in regional blood flow . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
25,
27
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
53,
64
]
} |
as for the latter , conventional monospecific sera against flv p30 and gp70 antigens as well as two distinct monoclonal antibodies recognizing flv gp70 epitopes were employed . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
76,
84
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
152,
160
]
} |
it is suggested that the low success rate in the treatment of patients with alcoholism in this study may have been due to the selection of subjects with advanced alcohol-related physical diseases . | NA | {
"id": "C0001973",
"name": "alcoholism",
"pos": [
76,
86
]
} | {
"id": "C0236664",
"name": "alcohol-related",
"pos": [
162,
177
]
} |
in the cases with carcinoma of pancreas , the morphological changes were the destruction and disappearance of b-cells due to the invasion of the carcinoma , the degeneration of b-cells due to the concomitant pancreatitis in the residual pancreatic tissue , and the atrophy and ballooning of pancreatic islet due to a pro... | NA | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
208,
220
]
} | {
"id": "C0149521",
"name": "chronic pancreatitis",
"pos": [
397,
417
]
} |
the evidence for this is that 1 ) the rate of accumulation of [ 3h ] inositol 1-phosphate is linear for up to 90 min in the presence of carbachol , 2 ) pretreatment of cells with 100 microm carbachol for 75 min does not diminish the subsequent ability of carbachol to increase [ 3h ] inositol 1-phosphate accumulation , ... | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
364,
383
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
438,
446
]
} |
doxorubicin ( adriamycin ) and daunomycin analogs have been examined for their ability to chelate iron and catalyze the oxidative cleavage of dna . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
0,
11
]
} | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
31,
41
]
} |
thus , the iron complexes of doxorubicin , daunomycin , carminomycin , and 4-demethoxydaunomycin are potent redox catalysts capable of reducing molecular oxygen in the presence of physiologic concentrations of glutathione . | NA | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
43,
53
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
56,
68
]
} |
thus , the iron complexes of doxorubicin , daunomycin , carminomycin , and 4-demethoxydaunomycin are potent redox catalysts capable of reducing molecular oxygen in the presence of physiologic concentrations of glutathione . | NA | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
43,
53
]
} | {
"id": "C0020789",
"name": "4-demethoxydaunomycin",
"pos": [
75,
96
]
} |
less potent agents such as pimozide , a diphenylbutylpiperidine , trifluoperazine and chlorpromazine , phenothiazines , and w-7 , a naphthalene sulfonamide , required higher concentrations for potentiation of bleomycin a2-induced cytotoxicity , while homologs that lack anticalmodulin activity failed to increase the cyt... | NA | {
"id": "C0040979",
"name": "trifluoperazine",
"pos": [
66,
81
]
} | {
"id": "C0031436",
"name": "phenothiazines",
"pos": [
103,
117
]
} |
less potent agents such as pimozide , a diphenylbutylpiperidine , trifluoperazine and chlorpromazine , phenothiazines , and w-7 , a naphthalene sulfonamide , required higher concentrations for potentiation of bleomycin a2-induced cytotoxicity , while homologs that lack anticalmodulin activity failed to increase the cyt... | NA | {
"id": "C0008286",
"name": "chlorpromazine",
"pos": [
86,
100
]
} | {
"id": "C0031436",
"name": "phenothiazines",
"pos": [
103,
117
]
} |
in this study , we examine the interaction of the mu agonist oxymorphone and delta agonist dstle ( d-ser2-thr6-leu-enkephalin ) with [ 3h ] d-ala2-d-leu5-enkephalin ( dadl ) binding to membranes of rat brain . | NA | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
111,
125
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
154,
164
]
} |
inheritance of extrachromosomal ribosomal dna during the asexual life cycle of dictyostelium discoideum : examination by use of dna polymorphisms . | NA | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
32,
45
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
128,
131
]
} |
these antibodies recognized 13 different epitopes which are different from the one previously identified with two other monoclonal antibodies [ doyen et al. , immun . lett . 3 , 365-370 ( 1981 ) ] . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
6,
16
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
120,
141
]
} |
four monoclonal antibodies directed against a given portion of the albumin molecule reacted slightly with another part of albumin , thus confirming the existence of an intramolecular cross-reactivity between the different domains of human albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
67,
74
]
} | {
"id": "C0304925",
"name": "human albumin",
"pos": [
233,
246
]
} |
to obtain maximum and reliable elicitation of anti-os antibodies of igg isotype the use for coupling of an os density corresponding to 10-25 moles of os/mole of bsa is recommended . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
54,
64
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
72,
79
]
} |
the antibody was subjected to recloning , and gave two separate homogeneous monoclonal antibodies with different affinity constants . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
4,
12
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
76,
97
]
} |
competitive-binding studies between the purified antibodies indicated the presence of two distinct epitopes on the antigen . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
99,
107
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
115,
122
]
} |
the distribution of the antigen ( s ) is not restricted to cells of the b-lineage as mature t-cells and a variety of non-hematopoietic cell types express both epitopes of the antigen ( s ) . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
159,
167
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
175,
182
]
} |
it is demonstrated that hydrolysis of atp by the uvra protein facilitates cross-linking of this protein to single-stranded dna , whether the dna is uv irradiated or not . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
107,
126
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
141,
144
]
} |
when allowed confluent holding periods of 1.5-24 h , gs , xpa and nhdf all exhibited a transient enhancement of mutagenesis such that a 5-10-fold increase in mutation frequency was observed in cells subcultured at 6-9 h after irradiation as compared to cells subcultured at 3-6 h . | NA | {
"id": "C0016030",
"name": "nhdf",
"pos": [
66,
70
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
253,
258
]
} |
after 24 h of confluent holding , the mutation frequency in irradiated gs and nhdf had returned to near background levels although xpa mutation frequencies remain similar to those observed in immediately subcultured cells . | NA | {
"id": "C0016030",
"name": "nhdf",
"pos": [
78,
82
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
216,
221
]
} |
effect of bile acids on formation of the mutagen , quercetin , from two flavonol glycoside precursors by human gut bacterial preparations . | NA | {
"id": "C0034392",
"name": "quercetin",
"pos": [
51,
60
]
} | {
"id": "C0060444",
"name": "flavonol",
"pos": [
72,
80
]
} |
human fecal cultures , induced with either of the flavonols , quercitrin or rutin , were grown in the presence of various concentrations of chenodeoxycholic acid , deoxycholic acid or cholic acid . | NA | {
"id": "C0060444",
"name": "flavonols",
"pos": [
50,
59
]
} | {
"id": "C0035976",
"name": "rutin",
"pos": [
76,
81
]
} |
human fecal cultures , induced with either of the flavonols , quercitrin or rutin , were grown in the presence of various concentrations of chenodeoxycholic acid , deoxycholic acid or cholic acid . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
140,
161
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
164,
180
]
} |
moreover , a special class of interferon ( immune interferon or ifn-gamma ) is produced by t cells following stimulation with antigen or interaction with mitogens . | NA | {
"id": "C0021747",
"name": "interferon",
"pos": [
30,
40
]
} | {
"id": "C0021745",
"name": "immune interferon",
"pos": [
43,
60
]
} |
an analysis of the 1,217-amino acid residue sequence of the precursor of mouse epidermal growth factor ( megf ) revealed regions of considerable similarity with bovine factor x , a blood coagulation factor . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
168,
176
]
} | {
"id": "C0005789",
"name": "blood coagulation factor",
"pos": [
181,
205
]
} |
the most abundant inhibitory neurotransmitter in the central nervous system , gamma-aminobutyric acid ( gaba ) , exerts its main effects via a gabaa receptor that gates a chloride channel in the subsynaptic membrane . | NA | {
"id": "C0034807",
"name": "gabaa receptor",
"pos": [
143,
157
]
} | {
"id": "C0055363",
"name": "chloride channel",
"pos": [
171,
187
]
} |
we propose that these codons do not represent termination codons in p. primaurelia but instead code for glutamic acid or glutamine and that the in vitro translation of paramecium mrnas is blocked by their presence . | NA | {
"id": "C0009221",
"name": "codons",
"pos": [
22,
28
]
} | {
"id": "C0242611",
"name": "termination",
"pos": [
46,
57
]
} |
we propose that these codons do not represent termination codons in p. primaurelia but instead code for glutamic acid or glutamine and that the in vitro translation of paramecium mrnas is blocked by their presence . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
104,
117
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
121,
130
]
} |
we believe that elevated sg is compensatory to a decreased response of the gastroduodenal mucosa to pg . | NA | {
"id": "C0017151",
"name": "sg",
"pos": [
25,
27
]
} | {
"id": "C0030859",
"name": "pg",
"pos": [
100,
102
]
} |
the increased purine and abnormal pyrimidine nucleotides of uremic rbc were unrelated to the pre- or posthemodialysis state , allopurinol , levels of blood lead , copper and zinc , or rbc pyrimidine 5'-nucleotidase , the cytosolic enzyme that specifically dephosphorylates the pyrimidine nucleotides . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
14,
20
]
} | {
"id": "C0002144",
"name": "allopurinol",
"pos": [
126,
137
]
} |
it was demonstrated that there was a higher proline incorporation and proline conversion to hydroxyproline in rats kept on the hypertensive regime . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
44,
51
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
92,
106
]
} |
they received intrajugular cannulae on the morning of proestrus and later between 12.00-13.00 h catecholamines - norepinephrine ( ne ; 5.3 or 15.9 micrograms ) , dopamine ( da ; 5.3 micrograms ) , epinephrine ( e ; 5.3 or 15.9 micrograms ) or vehicle ( artificial csf ) - were administered intraventricularly . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
113,
127
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
197,
208
]
} |
fibrin clot , fibrinopeptides , and fibrin degradation products did not prolong significantly the effect of thrombin or prevent the tachyphylaxis . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
0,
6
]
} | {
"id": "C0163275",
"name": "fibrin",
"pos": [
36,
42
]
} |
the cyst was removed by craniotomy and was found to be a mucocele on histological examination . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
4,
8
]
} | {
"id": "C0026683",
"name": "mucocele",
"pos": [
57,
65
]
} |
serial neuropsychological findings are contrasted in two cases : one with a syndrome of visual agnosia , the other with a disorder resulting from visual-verbal disconnection . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
76,
84
]
} | {
"id": "C0012634",
"name": "disorder",
"pos": [
122,
130
]
} |
clonidine ( 100 nm-10 microm ) , noradrenaline ( 10 microm-1 mm ) and adrenaline ( 10 microm-1 mm ) all reduced the duration of the spontaneously occurring action potential of the neurones . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
33,
46
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
70,
80
]
} |
in conditions of potassium current blockade , noradrenaline ( 100 microm-1 mm ) and adrenaline ( 20 microm-1 mm ) shortened the calcium action potential but clonidine was ineffective even at 10 microm . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
46,
59
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
84,
94
]
} |
this action of noradrenaline and adrenaline was not prevented by yohimbine ( 10 microm ) , propranolol ( 20 microm ) or prazosin ( 1 microm ) ; | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
15,
28
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
33,
43
]
} |
it is concluded that noradrenaline and adrenaline can directly inhibit calcium action potentials in locus coeruleus neurones when applied in high concentrations , but that this does not involve an alpha 2-adrenoceptor . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
21,
34
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
39,
49
]
} |
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