text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
muscimol and 3-amino-1-propanesulfonic acid , but not baclofen or glycine , mimicked the depolarization and conductance increase produced by gamma-aminobutyric acid on the melanotrophs . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
54,
62
]
} | {
"id": "C0016904",
"name": "gamma-aminobutyric acid",
"pos": [
141,
164
]
} |
the effect of two benzodiazepines , midazolam and diazepam , was studied in guinea-pig myenteric neurones , using intracellular recording techniques . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
18,
33
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
36,
45
]
} |
the effect of culture conditions , serum supplementation or chemically defined medium and the influence of thyroid hormone were studied on the development of the na+ , k+-adenosine triphosphatase ( na+ , k+-atpase ) and on the intracellular content of k+ and na+ ions in cultures which either were greatly enriched in a ... | NA | {
"id": "C0001473",
"name": "adenosine triphosphatase",
"pos": [
171,
195
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
325,
327
]
} |
the results indicate that gamma-aminobutyrate antagonists , bicuculline and picrotoxin when directly applied to the amygdala can elicit in rats motor limbic seizures , epileptic changes in the electroencephalogram indicative of repetitive limbic seizures , and status epilepticus accompanied by seizure-related brain dam... | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
168,
177
]
} | {
"id": "C0038220",
"name": "status epilepticus",
"pos": [
261,
279
]
} |
the results indicate that gamma-aminobutyrate antagonists , bicuculline and picrotoxin when directly applied to the amygdala can elicit in rats motor limbic seizures , epileptic changes in the electroencephalogram indicative of repetitive limbic seizures , and status epilepticus accompanied by seizure-related brain dam... | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
168,
177
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
295,
302
]
} |
in contrast , neither a bacterial hd nor other decarboxylases ( glutamic and dopa decarboxylases ) were immunoprecipitated . | NA | {
"id": "C0019605",
"name": "hd",
"pos": [
34,
36
]
} | {
"id": "C0007054",
"name": "decarboxylases",
"pos": [
82,
96
]
} |
it is concluded that the abuse liability of triazolam is less than that of the intermediate duration barbiturates such as pentobarbital . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
101,
113
]
} | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
122,
135
]
} |
analysis of agonists of the brain benzodiazepine binding site , such as chlordiazepoxide and diazepam , significantly increase exploration of a hole-board , of a two-chambered light in equilibrium dark apparatus , increase social interaction under high levels of illumination , increase consumption of a novel food in an... | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
34,
48
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
72,
88
]
} |
there were 20 patients with growth hormone ( gh ) secreting adenomas , 17 with prolactinomas ( 1 tumour secreted both gh and prolactin ) , 14 corticotrophin ( acth ) secreting adenomas and nine non-functioning pituitary adenomas . | NA | {
"id": "C0033375",
"name": "prolactinomas",
"pos": [
79,
92
]
} | {
"id": "C0001430",
"name": "adenomas",
"pos": [
220,
228
]
} |
the total amount of metronidazole prescribed in the study group was significantly larger than in the placebo group ( p less than .05 ) , whereas the amount of ampicillin/pivampicillin prescribed in the placebo group was significantly larger ( p less than .05 ) . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
159,
169
]
} | {
"id": "C0032032",
"name": "pivampicillin",
"pos": [
170,
183
]
} |
nucleoproteins revealed in the sperm with fully dispersed chromatin must be histones of the somatic type . | NA | {
"id": "C0028612",
"name": "nucleoproteins",
"pos": [
0,
14
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
58,
67
]
} |
automated threshold static perimetry with the humphrey field analyzer and kinetic and suprathreshold static perimetry with the goldmann perimeter were performed on 171 eyes : 69 with glaucoma or ocular hypertension , 69 with `` '' neurologic '' '' disorders , and 33 normal . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
183,
191
]
} | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
195,
214
]
} |
in 21 % of the eyes with glaucoma or ocular hypertension , defects were found with the humphrey perimeter that were not present with the goldmann perimeter . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
25,
33
]
} | {
"id": "C0028840",
"name": "ocular",
"pos": [
37,
43
]
} |
unlike most such cases , there were two distinct malignant components : adenoid cystic carcinoma and adenocarcinoma . | NA | {
"id": "C0010606",
"name": "adenoid cystic carcinoma",
"pos": [
72,
96
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
101,
115
]
} |
the hemolytic uremic syndrome is a disease of infancy , its major clinical manifestations include reversible thrombocytopenia , hemolytic anemia , and renal failure . | NA | {
"id": "C0019061",
"name": "hemolytic uremic syndrome",
"pos": [
4,
29
]
} | {
"id": "C0002878",
"name": "hemolytic anemia",
"pos": [
128,
144
]
} |
we have compared the serum levels of lipids ( cholesterol , triglycerides , high density lipoprotein cholesterol ) , apolipoproteins ( apo al and apo b ) and two ratios ( hdl cholesterol/vldl + ldl cholesterol and apo al/apo b ) between a population of 180 patients with atheromatous member lesions , divided into four s... | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
46,
57
]
} | {
"id": "C0023822",
"name": "high",
"pos": [
76,
80
]
} |
we have compared the serum levels of lipids ( cholesterol , triglycerides , high density lipoprotein cholesterol ) , apolipoproteins ( apo al and apo b ) and two ratios ( hdl cholesterol/vldl + ldl cholesterol and apo al/apo b ) between a population of 180 patients with atheromatous member lesions , divided into four s... | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
46,
57
]
} | {
"id": "C0023824",
"name": "cholesterol",
"pos": [
198,
209
]
} |
we have compared the serum levels of lipids ( cholesterol , triglycerides , high density lipoprotein cholesterol ) , apolipoproteins ( apo al and apo b ) and two ratios ( hdl cholesterol/vldl + ldl cholesterol and apo al/apo b ) between a population of 180 patients with atheromatous member lesions , divided into four s... | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
117,
132
]
} | {
"id": "C0003593",
"name": "apo",
"pos": [
221,
224
]
} |
in these events , the oxidation products of unsaturated fatty acids are of fundamental importance , in particular those derived from arachidonic acid ( prostaglandins , prostacyclins , thromboxanes and leukotrienes ) . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
152,
166
]
} | {
"id": "C0205911",
"name": "prostacyclins",
"pos": [
169,
182
]
} |
it was found that ( 1 ) tracheitis and bronchitis occurred significantly more frequently in infants exposed to cigarette smoke in the home , ( 2 ) maternal smoking imposed greater risks upon the infant than paternal smoking , ( 3 ) occurrence of neither tracheitis nor bronchitis showed a consistent relationship to the ... | NA | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
39,
49
]
} | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
722,
735
]
} |
this unusual syndrome occurred after introduction of a new intravenous vitamin e product ( e-ferol , alpha-tocopherol acetate ) for routine use in the intensive care nursery . | NA | {
"id": "C0042874",
"name": "vitamin e product",
"pos": [
71,
88
]
} | {
"id": "C1999896",
"name": "alpha-tocopherol acetate",
"pos": [
101,
125
]
} |
a solution of either tap water ( tw ) , carbonated water ( cw ) , 2 % sodium bicarbonate ( hco3- ) , or 3.5 % calcium chloride ( cacl2 ) with ph of 7.8 , 5.2 , 8.0 , and 7.4 , respectively , was infused into the crop at .41 ml x min-1 x kg body weight ( bw ) -1 . | NA | {
"id": "C0074722",
"name": "sodium bicarbonate",
"pos": [
70,
88
]
} | {
"id": "C0005367",
"name": "hco3",
"pos": [
91,
95
]
} |
over the three years period 1980-1982 , 18 256 pregnancies in the grampian region of n-e scotland including the islands of orkney and shetland were screened for raised levels of maternal serum alpha fetoprotein ( msafp ) in the second trimester . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
47,
58
]
} | {
"id": "C0032980",
"name": "second",
"pos": [
228,
234
]
} |
thirty six cases of fetal open neural tube defect in singletons were detected ( 18 anencephaly and 18 spina bifida ) . | NA | {
"id": "C0027794",
"name": "neural tube defect",
"pos": [
31,
49
]
} | {
"id": "C0002902",
"name": "anencephaly",
"pos": [
83,
94
]
} |
in thyroid diseases and in malnutrition ( anorexia nervosa ) , the 3 mh/cr ratio differentiates clearly marasmic malnutrition without increase in protein catabolism from hypercatabolic states , such as hyperthyroidism , with excessive protein degradation . | NA | {
"id": "C0040128",
"name": "thyroid",
"pos": [
3,
10
]
} | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
202,
217
]
} |
[ thrombopenia and thrombosis under heparin treatment . need for aggregation tests before treatment with low molecular weight heparin ] . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
36,
43
]
} | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
105,
133
]
} |
when aqueous solutions of dna were treated with 10-500 grays of gamma-rays , the imidazole rings of some adenine and guanine residues underwent scission , resulting in the conversion of these purines to formamidopyrimidines . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
105,
112
]
} | {
"id": "C0034140",
"name": "purines",
"pos": [
192,
199
]
} |
the smaller phosphoprotein is likely not a crystallin , because antibodies directed against alpha- , beta- , or gamma-crystallins do not cross-react with the 19-kda protein . | NA | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
12,
26
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
165,
172
]
} |
the smaller phosphoprotein is likely not a crystallin , because antibodies directed against alpha- , beta- , or gamma-crystallins do not cross-react with the 19-kda protein . | NA | {
"id": "C0010422",
"name": "crystallin",
"pos": [
43,
53
]
} | {
"id": "C0017030",
"name": "gamma-crystallins",
"pos": [
112,
129
]
} |
of the three distinct carbonic anhydrase ( carbonate dehydratase ; carbonate hydro-lyase , ec 4.2.1.1 ) isozymes , carbonic anhydrase i is erythrocyte-specific and , in humans , is under developmental control . | NA | {
"id": "C0007028",
"name": "carbonate hydro-lyase",
"pos": [
67,
88
]
} | {
"id": "C0007033",
"name": "carbonic anhydrase i",
"pos": [
115,
135
]
} |
comparison of restriction patterns between pathogenic and nonpathogenic mdv dna was made to identify a region of viral dna different between these two types of mdv , as it may be responsible for the tumorigenicity of mdv in chickens . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
76,
79
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
173,
174
]
} |
however , gamma-globin expression segregated by subcloning so that secondary and tertiary clones either expressed only beta-globin or co-expressed gamma- and beta-globin . | NA | {
"id": "C0017033",
"name": "gamma-globin",
"pos": [
10,
22
]
} | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
158,
169
]
} |
protein kinase c is thought to be physiologically activated by diacylglycerol derived from receptor-mediated phosphatidylinositol hydrolysis . sn-1,2-diacylglycerols with short saturated acyl side chains ( c4-c10 ) were synthesized and found to be potent activators of protein kinase c partially purified from hl-60 cell... | NA | {
"id": "C0043791",
"name": "diacylglycerol",
"pos": [
63,
77
]
} | {
"id": "C0012262",
"name": "diacylglycerols",
"pos": [
150,
165
]
} |
base composition analyses showed that the labeled dna was highly enriched in guanine and adenine residues , suggesting that the nick-translation reaction was asymmetrical and the strand enriched in purine was preferentially translated . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
89,
96
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
198,
204
]
} |
in addition , the rate constants of unlabeled s-cgp-12177 and s-alprenolol calculated using this method were in good agreement with those of s- [ 3h ] cgp-12177 and s- [ 3h ] dihydroalprenolol , respectively , determined independently . | NA | {
"id": "C0002334",
"name": "alprenolol",
"pos": [
64,
74
]
} | {
"id": "C0012278",
"name": "dihydroalprenolol",
"pos": [
175,
192
]
} |
in the absence of chloride , the hydrolysis proceeded at only 16 % of the maximal rate ( in 500 mm nacl ) , but in 10 mm nacl it increased to 64 % . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
18,
26
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
121,
125
]
} |
bovine papillomavirus type 1 ( bpv-1 ) and its cloned full-length dna can transform rodent cells in vitro , and the viral dna persists as an extrachromosomal multicopy plasmid in these transformed cells . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
66,
69
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
116,
125
]
} |
the major forms of beta-hexosaminidase ( 2-acetamido-2-deoxy-beta-d-glucoside acetamidodeoxyglucohydrolase , ec 3.2.1.30 ) occur as multimers of alpha and beta chains -- hexosaminidase a ( alpha beta a beta b ) and hexosaminidase b 2 ( beta a beta b ) . | NA | {
"id": "C0005270",
"name": "beta-hexosaminidase",
"pos": [
19,
38
]
} | {
"id": "C0162330",
"name": "hexosaminidase a",
"pos": [
170,
186
]
} |
the major forms of beta-hexosaminidase ( 2-acetamido-2-deoxy-beta-d-glucoside acetamidodeoxyglucohydrolase , ec 3.2.1.30 ) occur as multimers of alpha and beta chains -- hexosaminidase a ( alpha beta a beta b ) and hexosaminidase b 2 ( beta a beta b ) . | NA | {
"id": "C0005270",
"name": "beta-hexosaminidase",
"pos": [
19,
38
]
} | {
"id": "C0019481",
"name": "hexosaminidase b",
"pos": [
215,
231
]
} |
comparison of the amino acid sequence to those of other flavoproteins revealed two separate domains that are likely to be involved in flavin binding : a long segment ( residues 77-228 ) homologous with desulfovibrio vulgaris flavodoxin , an fmn-containing protein , and a shorter segment ( residues 452-477 ) homologous ... | NA | {
"id": "C0016223",
"name": "flavoproteins",
"pos": [
56,
69
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
256,
263
]
} |
the cjd proteins had molecular weights similar to those observed for scrapie prion proteins as determined by nadodso4 gel electrophoresis . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
8,
16
]
} | {
"id": "C0033164",
"name": "prion proteins",
"pos": [
77,
91
]
} |
we conclude that the molecular and biologic properties of the cjd agent are sufficiently similar to those of the scrapie prion protein that cjd should be classified as a prion disease . | NA | {
"id": "C0036457",
"name": "scrapie",
"pos": [
113,
120
]
} | {
"id": "C0162534",
"name": "prion disease",
"pos": [
170,
183
]
} |
the 104 amino acid proteoglycan core protein sequence reveals that the core protein is composed of three regions , the most striking of which is the central 49 amino acid region composed of alternating serine and glycine residues . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
8,
13
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
213,
220
]
} |
the serine-glycine repeat region is flanked by a 14 amino acid nh2-terminal region identical to the nh2-terminal sequence of the proteoglycan obtained by amino acid sequencing and a 41 amino acid cooh-terminal region . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
11,
18
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
185,
195
]
} |
phorbol 12-myristate 13-acetate and other phorbol esters induce an intracellular alkalinization in rat thymic lymphocytes . | NA | {
"id": "C0039654",
"name": "phorbol",
"pos": [
0,
7
]
} | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
42,
56
]
} |
the acrosome reaction is inhibited by ca2+ channel antagonists , including verapamil , d600 , and dihydropyridines such as nitrendipine , nimodipine , and nisoldipine . | NA | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
98,
114
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
123,
135
]
} |
the acrosome reaction is inhibited by ca2+ channel antagonists , including verapamil , d600 , and dihydropyridines such as nitrendipine , nimodipine , and nisoldipine . | NA | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
98,
114
]
} | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
138,
148
]
} |
a host-versus-graft reaction against allogeneic spleen cells was histologically detectable only when the cells were injected after a chemical peritonitis . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
37,
47
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
105,
110
]
} |
thus besides enhancing synthesis of lipoproteins , etoh at a moderately high dose ( 24 % of calories ) influences lipoprotein levels in primates by modifying lipid transfer processes ( ldl ) as well as by altering clearance ( hdl ) without adversely affecting liver function . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
36,
47
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
158,
163
]
} |
the production of txb2 during spontaneous clotting in infants with moderate hyperbilirubinemia ( serum total bilirubin 171-250 mumol/1 ) was higher than that in infants with mild ( serum bilirubin 100-170 mumol/1 ) or marked ( serum bilirubin greater than 250 mumol/1 ) jaundice . | NA | {
"id": "C0020433",
"name": "hyperbilirubinemia",
"pos": [
76,
94
]
} | {
"id": "C0022346",
"name": "jaundice",
"pos": [
270,
278
]
} |
although the serotonin depleting actions of fenfluramine in the d-amphetamine-treated rats generally paralleled those seen in the saline group ( i.e. , as in the hypothalamus ) , no such effects were noted in regions where baseline values ( see below ) were already lowered by d-amphetamine treatment ( i.e. , pons-medul... | NA | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
64,
77
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
279,
290
]
} |
conditions are described for the separation of norepinephrine , normetanephrine , 3-methoxy-4-hydroxyphenylglycol , epinephrine , metanephrine , dopamine , 3,4-dihydroxyphenylacetic acid , homovanillic acid , serotonin , and 5-hydroxyindole-3-acetic acid and for their quantitation in extracts of rat brain tissue . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
47,
61
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
64,
79
]
} |
conditions are described for the separation of norepinephrine , normetanephrine , 3-methoxy-4-hydroxyphenylglycol , epinephrine , metanephrine , dopamine , 3,4-dihydroxyphenylacetic acid , homovanillic acid , serotonin , and 5-hydroxyindole-3-acetic acid and for their quantitation in extracts of rat brain tissue . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
47,
61
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
116,
127
]
} |
conditions are described for the separation of norepinephrine , normetanephrine , 3-methoxy-4-hydroxyphenylglycol , epinephrine , metanephrine , dopamine , 3,4-dihydroxyphenylacetic acid , homovanillic acid , serotonin , and 5-hydroxyindole-3-acetic acid and for their quantitation in extracts of rat brain tissue . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
50,
61
]
} | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
130,
142
]
} |
the concentrations of gold in whole blood , serum , urine and blood cells of patients with rheumatoid arthritis were measured during 6 months of oral treatment either with auranofin or placebo . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
22,
26
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
172,
181
]
} |
although the time course of gold during auranofin therapy was similar to that of injected gold , the blood and serum gold concentrations were significantly lower than those measured in patients receiving injected gold . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
40,
49
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
213,
217
]
} |
between 45 and 58 % of auranofin gold in the blood was associated with blood cells . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
23,
32
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
33,
37
]
} |
it is suggested that the markedly lower concentrations of gold in the body sustained during treatment with auranofin may be the critical factor towards a greater tolerance of the drug in the treatment of rheumatoid arthritis . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
58,
62
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
107,
116
]
} |
ionisation ratios between water and polystyrene are presented , i.e . correction factors for converting ionisation readings in the plastic to readings in water required for electron dosimetry determinations . | NA | {
"id": "C0032604",
"name": "polystyrene",
"pos": [
36,
47
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
131,
138
]
} |
cellular and bacterial toxicities of four commonly used topical antimicrobials ( 1 % povidone-iodine , 3 % hydrogen peroxide , 0.25 % acetic acid , and 0.5 % sodium hypochlorite ) were assayed in vitro using cultures of human fibroblasts and staphylococcus aureus . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
0,
8
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
226,
237
]
} |
these radioresistant marrow fibroblastic cells were assayed for their ability to support normal granulopoiesis and found to be not significantly different from control fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
41,
46
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
168,
179
]
} |
this assay involves separation of the viral dna by agarose gel electrophoresis into three sharply demarcated bands corresponding to dna molecules containing a double-strand break ( dsb ) , single-strand breaks ( ssb ) , or no breaks . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
38,
47
]
} | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
132,
145
]
} |
75se- selenomethionine , 35s-methionine or sodium 75se-selenite in the amounts creating the absorbed dose in the body of 0.5 gy suppressed the delayed hypersensitivity reaction as was registered 1-12 months after the injection . | NA | {
"id": "C0036584",
"name": "selenomethionine",
"pos": [
6,
22
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
29,
39
]
} |
its absence , in the presence of an increased signal intensity within the disk , suggests a pathological process with a long t2 value , such as inflammation . | NA | {
"id": "C0030660",
"name": "pathological process",
"pos": [
92,
112
]
} | {
"id": "C0021368",
"name": "inflammation",
"pos": [
144,
156
]
} |
water-soluble contrast medium/barium study is preferable for the evaluation of certain postoperative complications such as anastomotic leak . | NA | {
"id": "C0032787",
"name": "postoperative",
"pos": [
87,
100
]
} | {
"id": "C0919691",
"name": "anastomotic leak",
"pos": [
123,
139
]
} |
the radiation response of human tumour xenografts has been shown to vary considerably among tumours of different histological types , tumours of the same histological type and cell subpopulations of single tumours . | NA | {
"id": "C0027651",
"name": "tumour",
"pos": [
32,
38
]
} | {
"id": "C0027652",
"name": "tumours of",
"pos": [
134,
144
]
} |
thrombo-embolic occlusions of the renal arteries are usually a result of co-existing cardiac disease , in most cases cardiac arrhythmias or ischaemic heart disease . | NA | {
"id": "C0018799",
"name": "cardiac disease",
"pos": [
85,
100
]
} | {
"id": "C0003811",
"name": "cardiac arrhythmias",
"pos": [
117,
136
]
} |
one monoclonal antibody ( r2 ) was radiolabelled and compared with 125i rabbit affinity purified antibody against f viii/vwf . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
4,
23
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
97,
105
]
} |
this monoclonal antibody could also be used in multimeric sizing and not only produced patterns identical to those obtained with the rabbit affinity purified antibody , but also gave better resolution . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
5,
24
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
158,
166
]
} |
this study demonstrates that one ( r2 ) of the four monoclonal antibodies is suitable for routine analysis of f viii/vwf and the use of this antibody simplifies the laboratory work in classifying von willebrand 's disease . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
52,
73
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
141,
149
]
} |
iron ( 3 mg ) was added as ferrous sulphate to 2 dl red wine , white wine and 7 % alcohol and its absorption was then measured in 38 fasting male subjects . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
0,
4
]
} | {
"id": "C0060282",
"name": "ferrous sulphate",
"pos": [
27,
43
]
} |
platelets of patients with myeloproliferative disorders ( md ) such as polycythaemia vera ( pv ) , chronic myelogenous leukaemia ( cml ) , idiopathic myelofibrosis ( im ) and essential thrombocythaemia ( et ) have been found to have low 5ht levels measured both by a fluorimetric and a liquid chromatographic assay . | NA | {
"id": "C0027022",
"name": "myeloproliferative disorders",
"pos": [
27,
55
]
} | {
"id": "C0001815",
"name": "idiopathic",
"pos": [
139,
149
]
} |
il-2 significantly enhanced lymphoproliferation , cell-mediated cytotoxicity to cmv-infected fibroblasts ( cmvf ) , natural killer cell activity , and the activity of cells capable of suppressing the response of fresh autologous cells to cmvffx of cells derived from control and csa-treated primary cultures . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
93,
104
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
248,
253
]
} |
acute respiratory failure in chronic obstructive lung disease ( copd ) is characterized by abnormal gas exchange and respiratory muscle fatigue ; | NA | {
"id": "C0600260",
"name": "obstructive lung disease",
"pos": [
37,
61
]
} | {
"id": "C0024117",
"name": "copd",
"pos": [
64,
68
]
} |
many of these reactions occur while the c1 compounds are linked to pteridine derivatives and tetrapyrrole coenzymes , including corrinoids , which are used to generate , reduce , or carbonylate methyl groups . | NA | {
"id": "C0076335",
"name": "tetrapyrrole",
"pos": [
93,
105
]
} | {
"id": "C1256766",
"name": "corrinoids",
"pos": [
128,
138
]
} |
crude extracts from short-term cultures of lymphocytes infected with lav bound rabbit antisera to the lav glycoprotein gp13 ( molecular weight 13,000 ) and the blv proteins p24 and gp51 , but did not bind antibodies to the p24 of human t-cell leukemia virus type i ( htlv-i ) . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
86,
94
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
205,
215
]
} |
in mouse hepatoma cells , tcdd induces the transcription of the cytochrome p1-450 gene , whose product , aryl hydrocarbon hydroxylase , contributes both to the detoxification and to the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons . | NA | {
"id": "C0059735",
"name": "cytochrome p1-450",
"pos": [
64,
81
]
} | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
105,
133
]
} |
the classical transplantation antigens ( the major histocompatibility complex class i antigens ) play a key role in host defense against cells expressing foreign antigens . | NA | {
"id": "C0019628",
"name": "transplantation antigens",
"pos": [
14,
38
]
} | {
"id": "C0019629",
"name": "major histocompatibility complex",
"pos": [
45,
77
]
} |
the thyroid glands of patients with autoimmune diseases such as graves ' disease and certain forms of goiter contain infiltrating activated t lymphocytes and , unlike cells of normal glands , the epithelial follicular cells strongly express histocompatibility antigens of the hla-dr type . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
36,
55
]
} | {
"id": "C0018213",
"name": "graves",
"pos": [
64,
70
]
} |
there is now considerable evidence that the antithrombotic and the hemorrhagic effects of heparin can be dissociated by using low molecular weight heparins and by using heparin with low affinity to at iii . | NA | {
"id": "C0019139",
"name": "low molecular weight heparins",
"pos": [
126,
155
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
169,
176
]
} |
in contrast to heparin , larger amounts of platelet factor 4 and protamine sulfate are needed to neutralize the anti-xa and anti-iia actions of this agent . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
15,
22
]
} | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
112,
119
]
} |
low molecular weight heparin fractions and fragments do not cause the pf4 rebound seen with intact heparin . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
0,
28
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
99,
106
]
} |
the cases were proven clinically by ophthalmologic and laboratory study , and their radiographic and joint changes were divided into five groups : no abnormal findings , osteoporosis , osteomalacia ( rickets ) , distinct changes , and miscellaneous . | NA | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
185,
197
]
} | {
"id": "C0035579",
"name": "rickets",
"pos": [
200,
207
]
} |
routine drainage of liver wounds created by trauma has recently been challenged , prompting a prospective , randomized trial of drainage via a penrose dam versus no drain in patients having emergency laparotomy for abdominal trauma . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
44,
50
]
} | {
"id": "C0848377",
"name": "abdominal trauma",
"pos": [
215,
231
]
} |
the persistent and recurrent pyodermas in these four patients indicate that ( 1 ) brown recluse spider bites may not be self-limited but induce pg or pg-like lesions ; | NA | {
"id": "C0034212",
"name": "pyodermas",
"pos": [
29,
38
]
} | {
"id": "C0085652",
"name": "pg",
"pos": [
150,
152
]
} |
as a developing country , mexico presents numerous health hazards to american visitors , including the prevalent travelers ' diarrhea ( turista ) , from which 40 % will suffer , and the less common typhoid , dengue , rabies , malaria , taeniasis , cysticercosis , and trichinosis . | NA | {
"id": "C0039254",
"name": "taeniasis",
"pos": [
236,
245
]
} | {
"id": "C0010678",
"name": "cysticercosis",
"pos": [
248,
261
]
} |
the patient underwent successful operation during the second trimester and the subsequent pregnancy and delivery were completely normal . | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
54,
70
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
90,
99
]
} |
thus , it appears that , for this dose of bp , the more rapid elimination of 14c in summer was due to a more rapid excretion of metabolites , and not to increased metabolism of bp . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
115,
124
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
163,
173
]
} |
glutathione s-sulfonate ( gsso3h ) is a reaction product of glutathione disulfide ( gssg ) and sulfite , the hydrated form of sulfur dioxide . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
0,
11
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
84,
88
]
} |
in children who sustain multiple injuries , urinary tract trauma is second only to trauma to the central nervous system . | NA | {
"id": "C0026771",
"name": "multiple injuries",
"pos": [
24,
41
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
83,
89
]
} |
in the period from august 1981 to april 1983 , 10243 random samples of urine from slaughtered cattle were inspected for the presence of the stilbene derivatives diethylstilbestrol ( des ) , dienestrol ( de ) , and hexestrol ( hex ) . | NA | {
"id": "C0038333",
"name": "stilbene",
"pos": [
140,
148
]
} | {
"id": "C0012203",
"name": "diethylstilbestrol",
"pos": [
161,
179
]
} |
in the period from august 1981 to april 1983 , 10243 random samples of urine from slaughtered cattle were inspected for the presence of the stilbene derivatives diethylstilbestrol ( des ) , dienestrol ( de ) , and hexestrol ( hex ) . | NA | {
"id": "C0012203",
"name": "diethylstilbestrol",
"pos": [
161,
179
]
} | {
"id": "C0019467",
"name": "hexestrol",
"pos": [
214,
223
]
} |
the presence of des was confirmed in 184 samples , de in 5 samples and hex in 14 samples . | NA | {
"id": "C0012203",
"name": "des",
"pos": [
16,
19
]
} | {
"id": "C0019467",
"name": "hex",
"pos": [
71,
74
]
} |
the availability of fluoride ( f ) from dicalcium phosphate ( dcp ) , defluorinated phosphate ( dfp ) , and raw rock phosphate ( rrp ) has been assessed and compared to the availability of f as naf . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
18,
19
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
194,
197
]
} |
the relative availability of f in the different phosphate sources measured by this technique compared to that of naf was about 50 % ( dcp ) , 20 % ( dfp ) , and 65 % ( rrp ) . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
27,
28
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
113,
116
]
} |
digestibility of f in goats fed similar diets was determined in a 4 x 4 latin square design experiment and found to be 38 % ( dcp ) , 34 % ( dfp ) , 65 % ( rrp ) , and 75 % ( naf ) . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
15,
16
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
175,
178
]
} |
three housed north ronaldsay sheep were treated with copper in the form of cupric oxide `` '' needles '' '' , two at the manufacturer 's recommended dosage rate and the third at twice this level . | NA | {
"id": "C0009968",
"name": "copper",
"pos": [
53,
59
]
} | {
"id": "C0056598",
"name": "cupric oxide",
"pos": [
75,
87
]
} |
positive immunostaining for s-100 protein was observed in pleomorphic adenoma , adenolymphoma , tubular adenoma , adenoid cystic carcinoma , acinic cell tumour , adenocarcinoma and carcinoma in pleomorphic adenoma . | NA | {
"id": "C0010606",
"name": "adenoid cystic carcinoma",
"pos": [
114,
138
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
162,
176
]
} |
unintegrated viral dna could not be detected in dnas extracted from the bursa bone marrow of osteopetrotic chickens or in dna extracted from the normal bones of an avian leukosis virus-infected chicken . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
13,
22
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
122,
125
]
} |
the paper deals with a study of lymphographic data on 204 cases of pediatric malignant lymphomas : primary hodgkin 's disease -- 150 and non-hodgkin 's lymphomas -- 54 . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
87,
96
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
137,
151
]
} |
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