text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
multistage carcinogenesis is the process of development of neoplastic changes , including the successive stages of initiation and promotion which occur in a strict order . | NA | {
"id": "C0596263",
"name": "carcinogenesis",
"pos": [
11,
25
]
} | {
"id": "C0027671",
"name": "process",
"pos": [
33,
40
]
} |
during modest and heavy exercise , free plasma noradrenaline and adrenaline are comparably low in statically and endurance trained athletes . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
47,
60
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
65,
75
]
} |
the results of a large number of epidemiological studies are indicating that there is a considerable genetic component in the liability for ischemic heart disorders ( especially for cardiac infarction in younger age groups ) , as well as for essential hypertension . | NA | {
"id": "C0151744",
"name": "ischemic heart disorders",
"pos": [
140,
164
]
} | {
"id": "C0027051",
"name": "cardiac infarction",
"pos": [
182,
200
]
} |
we could not find any relationship between myocardial adrenaline extraction and heart rate response to surgery or between myocardial noradrenaline extraction and changes in coronary blood flow , calculated coronary vascular resistance , incidence of myocardial ischaemia or cardiac dysrhythmias . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
54,
64
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
133,
146
]
} |
pancuronium ( pancuronium bromide ) 0.1 mg x kg b.w.-1 and alcuronium ( diallyl-nortoxiferine ) 0.25 mg x kg b.w.-1 were randomly studied in 36 patients during induction with high-dose fentanyl and in 36 patients induced with thiopentone , diazepam , fentanyl and nitrous oxide . | NA | {
"id": "C0030310",
"name": "pancuronium",
"pos": [
0,
11
]
} | {
"id": "C0030311",
"name": "pancuronium bromide",
"pos": [
14,
33
]
} |
in 120 premedicated patients undergoing general surgery , anaesthesia was induced with thiopentone 3 mg kg-1 , preceded by alfentanil 4.5 , 9.0 or 13.5 micrograms kg-1 or fentanyl 1.5 micrograms kg-1 . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
123,
133
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
171,
179
]
} |
after thiopentone , 30 , 7 and 17 % of the patients given alfentanil 9.0 and 13.5 micrograms kg-1 and fentanyl 1.5 micrograms kg-1 , respectively , reacted to pinching of the lower abdomen . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
58,
68
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
102,
110
]
} |
we conclude that the antinociceptive effect of alfentanil is distinctly shorter than that of fentanyl . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
47,
57
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
93,
101
]
} |
we measured epinephrine ( e ) , norepinephrine ( ne ) , serotonin ( 5-ht ) , angiotensin ii ( atii ) and arginine-vasopressin ( avp ) in plasma and carried out hemodynamic studies in 19 patients operated for coronary vascular disease . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
12,
23
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
32,
46
]
} |
bone growth and remodelling was studied in rats after injection of growth hormone , melanocyte-stimulating hormone ( alpha-msh ) , and cortisone daily for 20 days with tetracycline as intravital marker . | NA | {
"id": "C0026667",
"name": "melanocyte-stimulating hormone",
"pos": [
84,
114
]
} | {
"id": "C0002302",
"name": "alpha-msh",
"pos": [
117,
126
]
} |
immunization experiments with the isolated incl glial filament fraction produced antibodies reacting only with gfap but not with other types of intermediate filament proteins , furthermore indicating a high content of gfap in the isolated fraction . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
144,
174
]
} | {
"id": "C0017626",
"name": "gfap",
"pos": [
218,
222
]
} |
of 1 834 glucose profiles , 45 % were optimal , with all blood glucose values between 3.9 and 8.3 mmol/l . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
9,
16
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
57,
70
]
} |
the mean percentual difference in weight between the estimated and the actual weight was 1.2 % +/- 10.5 % ( 1 sd ) , which is acceptable for routine clinical use . | NA | {
"id": "C0005911",
"name": "difference",
"pos": [
20,
30
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
78,
84
]
} |
the purpose of this study was to elucidate the function of the ligamentous structures of the ankle joint , the traumas in which they may rupture , and the types of instability caused by such ruptures . | NA | {
"id": "C0043251",
"name": "traumas",
"pos": [
111,
118
]
} | {
"id": "C3203359",
"name": "ruptures",
"pos": [
191,
199
]
} |
the effect of lithium in vitro and in vivo on dopamine-sensitive adenylate cyclase activity in dopaminergic areas of the rat brain . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
46,
54
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
95,
107
]
} |
the results motivate further studies to elucidate possible effects of theophylline and other xanthines on the vascular resistance and blood flow in placenta . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
70,
82
]
} | {
"id": "C0043318",
"name": "xanthines",
"pos": [
93,
102
]
} |
in the adrenal extracts , the label co-chromatography mainly with cholesteryl ester , and in the brain extracts with cholesterol and with more polar lipids ( mainly phosphatidyl-choline and -ethanolamine ) . | NA | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
66,
83
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
117,
128
]
} |
transient effect of the combination of insulin and sulfonylurea ( glibenclamide ) on glycemic control in non-insulin dependent diabetics poorly controlled with insulin alone . | NA | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
51,
63
]
} | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
66,
79
]
} |
blood glucose was increased 30 min after glucose ingestion ( from 7.6 +/- 0.4 to 8.7 +/- 0.4 mmol/l , p less than 0.001 ) . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
0,
13
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
41,
48
]
} |
in 10 patients with the syndrome of multiple endocrine neoplasia , a positive correlation was found between tumour mass and the excretion of vanilmandelic acid , metanephrines and adrenaline . | NA | {
"id": "C0025562",
"name": "metanephrines",
"pos": [
162,
175
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
180,
190
]
} |
as a result of bleeding at the incision site , a hematoma forms between the bladder and lower uterine segment . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
15,
23
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
49,
57
]
} |
their ability to relieve pain is independent of the presence of clinical depression , and their efficacy has been documented in the treatment of migraine and tension headaches , neuropathic pain and chronic pain syndromes , including those associated with cancer . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
25,
29
]
} | {
"id": "C0027796",
"name": "neuropathic pain",
"pos": [
178,
194
]
} |
in order to determine to what extent left ventriculographic abnormalities can be predicted from ecg changes in myocardial infarction ( mi ) , 87 unipolar ecgs were simultaneously recorded in 22 patients with previous anterior mi with no conduction defects . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
111,
132
]
} | {
"id": "C0340293",
"name": "anterior mi",
"pos": [
217,
228
]
} |
in langendorff-perfused hearts from nine atherosclerotic rabbits ( 2 % cholesterol diet for 18 weeks ) , despite a threefold increase of cholesterol concentration in the coronary wall compared with nine control rabbits , ergonovine and serotonin did not produce any increase of coronary vascular resistances ; | NA | {
"id": "C0008395",
"name": "cholesterol",
"pos": [
71,
82
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
137,
148
]
} |
sympathetic function was assessed by determining arterial plasma norepinephrine ( plasma ne ) and epinephrine ( plasma e ) in supine and upright positions , both before and after dialysis . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
65,
79
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
98,
109
]
} |
less than 2 % of the unchanged drug appear in the urine , but renal excretion is the main route of elimination of the metabolites in humans ( 90 % to 95 % ) . | NA | {
"id": "C1373187",
"name": "renal excretion",
"pos": [
62,
77
]
} | {
"id": "C1373186",
"name": "route of",
"pos": [
90,
98
]
} |
the most severe segmental abnormality was hypokinesia in 22 % , akinesia in 45 % and dyskinesia in 14 % . | NA | {
"id": "C0086439",
"name": "hypokinesia",
"pos": [
42,
53
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
85,
95
]
} |
systemic and coronary hemodynamic effects of a new dihydropyridine calcium antagonist , nicardipine , were studied in 15 patients . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium",
"pos": [
51,
74
]
} | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
88,
99
]
} |
on control holter recordings , 55 patients ( group i ) had frequent ( more than 10 extrasystoles per hour ) and/or complex ( at least couplets ) ventricular ectopic activity ( vea ) , and 19 patients ( group ii ) had infrequent and simple vea . | NA | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
83,
96
]
} | {
"id": "C0151636",
"name": "vea",
"pos": [
239,
242
]
} |
the predictive accuracy of a positive holter monitor response as an indicator for subsequent prevention of sustained ventricular tachyarrhythmias and sudden cardiac death was 82 % and for a negative holter monitor response as an indicator of tachyarrhythmia or sudden death recurrence on therapy it was 52 % . | NA | {
"id": "C0085298",
"name": "sudden",
"pos": [
150,
156
]
} | {
"id": "C0011071",
"name": "sudden death",
"pos": [
261,
273
]
} |
the results indicate that cardiac chamber enlargement , lv hypertrophy and lv systolic dysfunction occur frequently in morbidly obese patients and that lv systolic dysfunction in such persons may improve following substantial weight loss . | NA | {
"id": "C0018800",
"name": "cardiac",
"pos": [
26,
33
]
} | {
"id": "C0149721",
"name": "lv",
"pos": [
152,
154
]
} |
flecainide acetate , an investigational class 1 antiarrhythmic agent , undergoes biotransformation in man with production of 2 major metabolites : meta-o-dealkylated flecainide ( s-24623 ) and the meta-o-dealkylated lactam of flecainide ( s-26191 ) . | NA | {
"id": "C0086303",
"name": "flecainide acetate",
"pos": [
0,
18
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
226,
236
]
} |
while these relationships were similar for men and women , among women they were stronger for those using gonadal hormones than among those not using these hormones . | NA | {
"id": "C0301819",
"name": "gonadal hormones",
"pos": [
106,
122
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
156,
164
]
} |
method 1 gave clear positive results in each case with antibody ae-1 and , in most cases , with the polyclonal antisera . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
55,
63
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
111,
119
]
} |
the lesions resulted from inadvertent application of squeezed lime juice to the children 's skin by their parents during the routine preparation of drinks , followed by sun exposure , which activated the applied plant psoralens ( furocoumarins ) . | NA | {
"id": "C0033858",
"name": "psoralens",
"pos": [
218,
227
]
} | {
"id": "C0016859",
"name": "furocoumarins",
"pos": [
230,
243
]
} |
in a newborn screening program for abnormal hemoglobins , 91 infants were found to have hemoglobin as or ac . | NA | {
"id": "C0019016",
"name": "a",
"pos": [
3,
4
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
88,
98
]
} |
the clinical and pathologic data from these three children suggest that adenovirus may be an important agent in initiating reye 's syndrome in the very young child . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
50,
58
]
} | {
"id": "C0728836",
"name": "young child",
"pos": [
152,
163
]
} |
in addition , two other newborns diagnosed as alpha thal1 trait carriers ( one malay , one chinese ) were shown to have a deletion of both alpha globin genes by quantitative alpha globin gene analysis , but further testing with zeta globin gene probe failed to reveal an abnormal fragment length characteristic of an alp... | NA | {
"id": "C0043472",
"name": "zeta globin",
"pos": [
228,
239
]
} | {
"id": "C0002270",
"name": "alpha globin",
"pos": [
317,
329
]
} |
we believe that this last condition is due to a large deletion which includes all alpha globin genes and all zeta globin genes on the same chromosome . | NA | {
"id": "C0002270",
"name": "alpha globin",
"pos": [
82,
94
]
} | {
"id": "C0043472",
"name": "zeta globin",
"pos": [
109,
120
]
} |
four recombinant dna clones ( h1 , h7 , h12 , and h15 ) carrying low-repetitive human dna were previously isolated from a human genomic library based on their specificity for chromosome 21 and were studied for their distribution as determined by in situ hybridization . | NA | {
"id": "C0012931",
"name": "recombinant dna",
"pos": [
5,
20
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
86,
89
]
} |
homozygosity for a mutant allele at the beta-chain locus of hexosaminidase ( hex ) , resulting in a variant of heat-labile hex b , is reported for the first time in two healthy children . | NA | {
"id": "C1956070",
"name": "beta-chain",
"pos": [
40,
50
]
} | {
"id": "C0162330",
"name": "a",
"pos": [
171,
172
]
} |
plasma free epinephrine , norepinephrine , and dopamine concentrations were determined in 48 , 63 , and 45 patients , respectively , with overt congestive heart failure , and compared with those in 26 patients with stable angina but without heart failure . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
12,
23
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
26,
40
]
} |
cationic antibody may also localize first , and deposits can form from subendothelial immune complex deposits dissociating to cross the gbm and re-form in a subepithelial distribution . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
9,
17
]
} | {
"id": "C0003313",
"name": "immune complex",
"pos": [
86,
100
]
} |
proteinuria induced by subepithelial immune deposit formation appears to be due to a direct effect of complement , probably involving membrane attack complexes , and independent of inflammatory cells . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
102,
112
]
} | {
"id": "C0009545",
"name": "membrane attack complexes",
"pos": [
134,
159
]
} |
there was a significant increase in plasma norepinephrine , 664.9 +/- 91.6 to 1384.8 +/- 216.7 pg/ml ( p less than 0.02 ) and epinephrine , 224.6 +/- 43.6 to 681.7 +/- 199.0 pg/ml ( p less than 0.01 ) with hemorrhage . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
43,
57
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
126,
137
]
} |
the decline in total mortality in this weight group due to improved small-group , birth weight-specific mortality was contrasted to the increase in mortality caused by changes in the birth weight distribution resulting from the care of smaller infants . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
39,
45
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
183,
195
]
} |
in comparison to laparoscopically detected salpingitis , endometritis detected with biopsy had a sensitivity of 89 % , a specificity of 67 % , a positive predictive value of 84 % , and a false negative rate of 22 % in the diagnosis of pelvic inflammatory disease . | NA | {
"id": "C0014179",
"name": "endometritis",
"pos": [
57,
69
]
} | {
"id": "C0242172",
"name": "pelvic inflammatory disease",
"pos": [
235,
262
]
} |
this study demonstrates that nonpuerperal endometritis is an entity associated with pelvic inflammatory disease , most likely representing an intermediate stage between cervicitis and salpingitis . | NA | {
"id": "C0014179",
"name": "endometritis",
"pos": [
42,
54
]
} | {
"id": "C0242172",
"name": "pelvic inflammatory",
"pos": [
84,
103
]
} |
some of the toxicities of pan are nonspecific , in that the constituent molecules of pan ( adenosine and puromycin ) cause similar effects in vitro . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
91,
100
]
} | {
"id": "C0034145",
"name": "puromycin",
"pos": [
105,
114
]
} |
some of the effects of pan are not reproduced by adenosine or puromycin and are inhibited by the simultaneous presence of n6-monomethyl adenosine ( mma ) , a pan analog and an in vivo blocker of nephrosis due to pan . | NA | {
"id": "C0034145",
"name": "puromycin",
"pos": [
62,
71
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
136,
145
]
} |
in chronic pancreatic fistula dogs , dose-response studies were performed to determine the effect of proglumide on the pancreatic responses to octapeptide of cck ( cck-op ) , intravenous bethanechol , intraduodenal amino acids , and intraduodenal fat . | NA | {
"id": "C0037167",
"name": "octapeptide",
"pos": [
143,
154
]
} | {
"id": "C0008328",
"name": "cck",
"pos": [
164,
167
]
} |
intestinal myoelectric activity was measured in four conscious dogs with implanted monopolar electrodes after administration of prostaglandins ( pg ) and indomethacin ( indo ) , a potent inhibitor of pg biosynthesis . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
128,
142
]
} | {
"id": "C0033555",
"name": "a",
"pos": [
178,
179
]
} |
antibody mechanisms involving either direct glomerular ( and tubular ) fixation of antibody or accumulation of immune complex materials provide an array of acute and chronic lesions for evaluation with relevance to the bulk of immune glomerular and tubular lesions in humans . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0003313",
"name": "immune complex",
"pos": [
111,
125
]
} |
ventriculocisternal perfusion of ang ii or its antagonist saralasin was accomplished via needles inserted in the left lateral cerebral ventricle and cisterna magna . | NA | {
"id": "C0003009",
"name": "ang ii",
"pos": [
33,
39
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
58,
67
]
} |
this mechanism is physiologically significant because either nephrectomy or functional elimination of ang ii by saralasin greatly attenuates the adrenal medullary response to hemorrhage in vivo . | NA | {
"id": "C0003009",
"name": "ang ii",
"pos": [
102,
108
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
112,
121
]
} |
when vasopressin antidiuretic hormone ( adh ) was infused intravenously at the same time of ivt sq infusion , the rise in temperature was depressed , but adh did not lower the temperature below basal . | NA | {
"id": "C0003779",
"name": "vasopressin",
"pos": [
5,
16
]
} | {
"id": "C0042413",
"name": "adh",
"pos": [
154,
157
]
} |
complications associated with the tenckhoff catheter were either mechanical ( intraabdominal organ injury , incisional hernia , catheter leakage , catheter occlusion , or catheter dislodgement ) , or infectious ( peritonitis or abdominal wall infection ) . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
200,
210
]
} | {
"id": "C1112209",
"name": "abdominal",
"pos": [
228,
237
]
} |
using radioimmunoassay and high pressure liquid chromatography ( hplc ) , we have identified the srs-a sulphidopeptide leukotrienes ( ltc4 , ltd4 and lte4 ) in nasal washings from patients with allergic rhinitis who underwent nasal challenge with specific allergen . | NA | {
"id": "C0038091",
"name": "srs-a",
"pos": [
97,
102
]
} | {
"id": "C0023545",
"name": "leukotrienes",
"pos": [
119,
131
]
} |
using radioimmunoassay and high pressure liquid chromatography ( hplc ) , we have identified the srs-a sulphidopeptide leukotrienes ( ltc4 , ltd4 and lte4 ) in nasal washings from patients with allergic rhinitis who underwent nasal challenge with specific allergen . | NA | {
"id": "C0038091",
"name": "srs-a",
"pos": [
97,
102
]
} | {
"id": "C0023542",
"name": "ltc4",
"pos": [
134,
138
]
} |
using radioimmunoassay and high pressure liquid chromatography ( hplc ) , we have identified the srs-a sulphidopeptide leukotrienes ( ltc4 , ltd4 and lte4 ) in nasal washings from patients with allergic rhinitis who underwent nasal challenge with specific allergen . | NA | {
"id": "C0038091",
"name": "srs-a",
"pos": [
97,
102
]
} | {
"id": "C0023544",
"name": "ltd4",
"pos": [
141,
145
]
} |
using radioimmunoassay and high pressure liquid chromatography ( hplc ) , we have identified the srs-a sulphidopeptide leukotrienes ( ltc4 , ltd4 and lte4 ) in nasal washings from patients with allergic rhinitis who underwent nasal challenge with specific allergen . | NA | {
"id": "C0038091",
"name": "srs-a",
"pos": [
97,
102
]
} | {
"id": "C0125644",
"name": "lte4",
"pos": [
150,
154
]
} |
alfentanil , a potent short acting analgetic , is used for short operations instead of fentanyl as a neurolept anaesthesia agent . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
0,
10
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
87,
95
]
} |
alfentanil and fentanyl were compared as supplements to thiopentone , nitrous oxide , relaxant anaesthesia in a randomised , double blind trial carried out on 55 adult patients undergoing elective surgery . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
0,
10
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
15,
23
]
} |
the fentanyl-treated patients resumed spontaneous ventilation more rapidly at the end of anaesthesia ( 3 minutes ) than the alfentanil-treated group ( 5.1 minutes , p less than 0.02 ) . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
4,
12
]
} | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
124,
134
]
} |
a computer model is used to explain why , despite the shorter elimination half-life , the alfentanil-treated patients did not awaken more rapidly than those in the fentanyl group . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
90,
100
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
164,
172
]
} |
during eeg recording , six unpremedicated patients received a fentanyl infusion ( 150 micrograms/min ) , and six received alfentanil ( 1,500 micrograms/min ) until a specific level of eeg depression ( delta waves ) occurred . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
62,
70
]
} | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
122,
132
]
} |
with fentanyl a significantly greater time lag was present ( half-time = 6.4 +/- 1.3 min ; mean +/- sd ) than with alfentanil ( half-time = 1.1 +/- 0.3 min ) . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
5,
13
]
} | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
115,
125
]
} |
the steady-state serum concentration that caused one-half of the maximal eeg slowing was 6.9 +/- 1.5 ng/ml for fentanyl , compared with 520 +/- 163 ng/ml for alfentanil . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
111,
119
]
} | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
158,
168
]
} |
epidural anesthesia induced significant ( p less than 0.05 ) decreases from control values in mean arterial pressure and plasma norepinephrine ( from 85 +/- 6 to 67 +/- 8 mmhg and from 600 +/- 108 to 307 +/- 77 pg/ml , respectively , mean +/- sem ) without significant changes in heart rate , plasma epinephrine , renin ... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
128,
142
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
300,
311
]
} |
simultaneously , an increase in plasma vasopressin ( from 14.8 +/- 5.5 to 36.2 +/- 10.3 and 40.0 +/- 10.5 pg/ml ) was recorded , whereas plasma norepinephrine and epinephrine remained unchanged . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
144,
158
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
163,
174
]
} |
venom from young ( 0 to 48 hours after eclosion ) vespa orientalis should presumably be less allergenic and/or antigenic than venom from adult hornets . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
93,
103
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
111,
120
]
} |
the bird 's presence caused complaints of allergic rhinitis , while the ingestion of eggs caused urticaria and angioedema . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
97,
106
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
111,
121
]
} |
alpha 1-protease inhibitor ( alpha 1pi ) , an acute-phase reactant , is the major inhibitor of neutral proteases causing lung tissue injury , such as elastase . | NA | {
"id": "C0002191",
"name": "alpha 1-protease inhibitor",
"pos": [
0,
26
]
} | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
46,
66
]
} |
alveolar macrophages ( am ) can be stimulated in vitro with material such as lipopolysaccharide , and this activation releases cytokines , collectively called interleukin-1 , that can stimulate local cells such as fibroblasts , systemic cells such as lymphocytes , and/or distant parenchymal cells such as hepatocytes . | NA | {
"id": "C0016030",
"name": "cells",
"pos": [
200,
205
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
292,
297
]
} |
on the basis of clinical and radiologic findings as well as pulmonary function tests , 91 smokers were classified as smokers without lung disease , with small airway disease , with simple chronic bronchitis , with obstructive bronchitis , with pulmonary emphysema , and with lung cancer . | NA | {
"id": "C0024117",
"name": "small",
"pos": [
153,
158
]
} | {
"id": "C0034067",
"name": "pulmonary emphysema",
"pos": [
244,
263
]
} |
we found that the addition of ketones ( preferably acetone ) to the catalyst solution ( mnso4 ) accelerates the reaction in such a manner that heating is not necessary and the full color development can be obtained within 6 min . | NA | {
"id": "C0022634",
"name": "ketones",
"pos": [
30,
37
]
} | {
"id": "C0001002",
"name": "acetone",
"pos": [
51,
58
]
} |
in a regression analysis the weight and length velocities are analysed in relation to feeding habits , birth weight , birth length and some other factors . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
29,
35
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
103,
115
]
} |
the aim of this study was to determine if there are any age-related changes in serum lipids , lipoproteins and alpha-tocopherol concentrations during adolescence and whether a permanent relationship between lipoproteins and alpha-tocopherol can be observed . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
94,
106
]
} | {
"id": "C0065058",
"name": "a",
"pos": [
242,
243
]
} |
the topography of the arterial supply to nerves and their abundant collateral circulation may explain the centrifascicular distribution of nerve infarcts , and in part can account for the apparent resistance of peripheral nerves to ischemia . | NA | {
"id": "C0021308",
"name": "infarcts",
"pos": [
145,
153
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
232,
240
]
} |
the assay was dependent on nitrate concentration , and optimal activity was obtained with a final concentration of 0.2 % potassium nitrate . | NA | {
"id": "C0028125",
"name": "nitrate",
"pos": [
27,
34
]
} | {
"id": "C0071772",
"name": "potassium nitrate",
"pos": [
121,
138
]
} |
among the ribosomal rna species , only the 5 s rna species was released from the ribosomal particles upon treatment . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
10,
23
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
47,
50
]
} |
weanling , male sprague-dawley rats were fed a vitamin e-deficient diet containing 10 % tocopherol-stripped corn oil ( co ) or 5 % cod liver oil ( clo ) with or without 40 mg dl-alpha-tocopheryl acetate/kg . | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
47,
56
]
} | {
"id": "C0994472",
"name": "dl-alpha-tocopheryl acetate",
"pos": [
175,
202
]
} |
to induce a high , sustained level of lipid peroxidation , some rats were injected intraperitoneally with 100 mg of iron as iron dextran after 10 days of feeding . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
116,
120
]
} | {
"id": "C0022092",
"name": "iron dextran",
"pos": [
124,
136
]
} |
the cyclopropyl oxiranes all showed low ( 26-60 % at 5 x 10 ( -4 ) m ) inhibition of glutathione transferase and moderate inhibition ( i50 = 5 x 10 ( -4 ) to 6 x 10 ( -6 ) m ) for ceh and meh . cis-phenylcyclopropyl oxirane had an i50 for meh near that for a commonly used inhibitor , 1,1,1-trichloropropene oxide . | NA | {
"id": "C0014630",
"name": "oxiranes",
"pos": [
16,
24
]
} | {
"id": "C0015087",
"name": "oxirane",
"pos": [
216,
223
]
} |
unsaturated fatty acid isomers : effects on the circadian rhythm of a fatty-acid-deficient neurospora crassa mutant . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acid",
"pos": [
0,
22
]
} | {
"id": "C0015684",
"name": "fatty-acid",
"pos": [
70,
80
]
} |
in air-free solutions , nucleic acid bases are oxidized by the photoexcited drug molecules predominantly generating c ( 5 ) -carbon-centered radicals in the pyrimidine rings of uracil , cytosine , and thymine . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
177,
183
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
201,
208
]
} |
in air-saturated adriamycin and daunomycin solutions , the spin adducts of mnp with uracil or thymine are similar to those obtained following hydroxyl radical reactions with these pyrimidines . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
84,
90
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
94,
101
]
} |
insulin resistance and hyperinsulinemia seem to be commonly associated with ( and perhaps causative of ) the acanthosis nigricans that is seen in many endocrine diseases . | NA | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
0,
18
]
} | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
23,
39
]
} |
these observations ( negative patch test reactions , positive intradermal test reactions ) suggest that the route of administration may be an important determinant of antigenic hapten-protein complex formation and subsequent delayed hypersensitivity responses involving cutaneous or mucocutaneous tissue . | NA | {
"id": "C0003316",
"name": "determinant",
"pos": [
152,
163
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
177,
183
]
} |
16 had the complete or incomplete syndrome of calcinosis , rp , esophageal dysmotility , sclerodactyly , and telangiectasia ( crest syndrome ) ; | NA | {
"id": "C0006663",
"name": "calcinosis",
"pos": [
46,
56
]
} | {
"id": "C0206138",
"name": "crest syndrome",
"pos": [
126,
140
]
} |
allergens were prepared from wheat , gluten , gliadin , and glutenin by simple extraction and enzyme digestion , and these preparations were used in skin tests . | NA | {
"id": "C2362561",
"name": "gluten",
"pos": [
37,
43
]
} | {
"id": "C0017622",
"name": "gliadin",
"pos": [
46,
53
]
} |
the allergens obtained from gluten , gliadin , and glutenin by pepsin digestion were qualitatively different from wheat and gluten allergens obtained by simple extraction and were more related to exercise-induced anaphylaxis . | NA | {
"id": "C0017622",
"name": "gliadin",
"pos": [
37,
44
]
} | {
"id": "C2362561",
"name": "gluten",
"pos": [
124,
130
]
} |
although the stratum corneum of patients with li was two to three times thicker than that of those with cie , the latter group demonstrated more acanthosis , parakeratosis , hypergranulosis , and less prominent dermal capillaries . | NA | {
"id": "C0079154",
"name": "li",
"pos": [
46,
48
]
} | {
"id": "C0079583",
"name": "cie",
"pos": [
104,
107
]
} |
these clinical , histologic , and biochemical findings provide useful guidelines to differentiate cie from li and strongly suggest that autosomal recessive primary ichthyosis comprises two distinct diseases . | NA | {
"id": "C0079583",
"name": "cie",
"pos": [
98,
101
]
} | {
"id": "C0079154",
"name": "li",
"pos": [
107,
109
]
} |
this study was designed to test the effects of pentagastrin and epidermal growth factor ( egf ) on stress-induced ulceration and on the antral content of gastrin and somatostatin ( sli ) in rats . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
47,
59
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
154,
161
]
} |
the utility of nitrates , including intravenous nitroglycerin , in the treatment of unstable angina and vasospastic angina is well documented . | NA | {
"id": "C0002965",
"name": "unstable",
"pos": [
84,
92
]
} | {
"id": "C0002963",
"name": "vasospastic angina",
"pos": [
104,
122
]
} |
after methylphenidate administration , both norepinephrine ( ne ) and normetanephrine ( nmn ) concentrations were significantly elevated , and there was a 22 % increase in excretion of 3-methoxy-4-hydroxyphenylglycol ( mhpg ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
44,
58
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
70,
85
]
} |
in contrast , after dextroamphetamine treatment , mhpg excretion was significantly reduced and ne and nmn values were unchanged . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
35,
37
]
} | {
"id": "C0028385",
"name": "nmn",
"pos": [
102,
105
]
} |
these data provide objective evidence for decreases in motor activity that occur concomitantly with the depressive phase of illness in patients with affective disorder , and fluctuate in patients in euthymic or manic phases . | NA | {
"id": "C0011581",
"name": "depressive",
"pos": [
104,
114
]
} | {
"id": "C0525045",
"name": "affective",
"pos": [
149,
158
]
} |
one of the moab designated 15e2e2 that belonged to the first group of reproducibly staining antibodies was used to stain a larger number of normal human tissues and neoplasms . | NA | {
"id": "C0003250",
"name": "moab",
"pos": [
11,
15
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
92,
102
]
} |
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