Datasets:
DFKI-SLT
/
BioRel

Dataset card Data Studio Files
xet
 Community
1
text
stringlengths
57
1.72k
relation
stringclasses
125 values
h
dict
t
dict
when acid and beta-galactosidase-treated human tracheobronchial mucin was used as the acceptor , 3.3 % of the product was found as [ 14c ] gal-galnac-h2 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 41, 46 ] }
{ "id": "C0919509", "name": "h2", "pos": [ 150, 152 ] }
with antibody 18 and other monoclonal antibodies of known specificity , da2 and genox 3.53 , we showed that a remarkably high proportion of human pulmonary macrophages express hla-dr framework and dc1 polymorphic determinants in culture .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 140, 145 ] }
{ "id": "C1415570", "name": "dc1", "pos": [ 197, 200 ] }
the fate of horse anti-human lymphocyte globulins , rabbit anti-human beta2 microglobulin antibodies and anti-hl-a alloantibodies radiolabelled with 125i and complexed to their corresponding lymphocyte surface antigens , was investigated .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 23, 28 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 70, 75 ] }
unreduced human subcomponent c1q was shown by electrophoresis on polyacrylamide gels run in the presence of sodium dodecyl sulphate to be composed of two types of non-covalently linked subunits of apparent mol.wts .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 10, 15 ] }
{ "id": "C1705714", "name": "wts", "pos": [ 210, 213 ] }
analysis on starch gel electrophoresis revealed that not only the human homodimer , but also human-mouse heterodimer molecules , in cases of pgi and idh , were precipitated .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 66, 71 ] }
{ "id": "C2697642", "name": "idh", "pos": [ 149, 152 ] }
human g myeloma ( 7s gamma ( 2 ) -myeloma ) proteins were investigated for relationships between gm and inv genetic factors and the different antigenic types of heavy polypeptide chains ( gamma-chains ) and light polypeptide chains .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1420192", "name": "heavy", "pos": [ 161, 166 ] }
vertebrates from fish to human were shown to contain dna sequence ( c-yes ) homologous with viral yes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 25, 30 ] }
{ "id": "C0919479", "name": "c-yes", "pos": [ 68, 73 ] }
in general , techniques used for human ivf are applicable to the chimpanzee with modifications in culture medium and aspiration techniques as described here .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 33, 38 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 39, 42 ] }
this paper provides the first documentation of ivf in the chimpanzee , a species with significant potential to provide data of value in expansion of application of human ivf .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 164, 169 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 170, 173 ] }
the possibility that this also occurred in humans was explored by immunizing 42 pregnant women with tetanus toxoid ( 2.5 or 5 lf ) in the fifth and eighth months of pregnancy and comparing the immune responses of their offspring with the responses of the offspring of 25 unimmunized mothers .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 43, 49 ] }
{ "id": "C1416933", "name": "lf", "pos": [ 126, 128 ] }
evidence for a new form of retroviral env transcript in leukemic and normal mouse lymphoid cells .
organism_has_gene
{ "id": "C0035366", "name": "retroviral", "pos": [ 27, 37 ] }
{ "id": "C0017343", "name": "env", "pos": [ 38, 41 ] }
here , using molecular clones of htlv and human major histocompatibility antigen dna , we have shown homology between the envelope gene region of htlv and the region of an hla-b locus gene which codes for the extracellular portion of a class i histocompatibility antigen .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 42, 47 ] }
{ "id": "C1415561", "name": "hla-b", "pos": [ 172, 177 ] }
this gene was cloned from a recombinant library of burkitt 's lymphoma dna and identified as a human homologue of chicken blym-1 , the transforming gene detected by transfection of chicken b-cell lymphoma dna .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 95, 100 ] }
{ "id": "C0029016", "name": "transforming gene", "pos": [ 135, 152 ] }
we have recently shown that dms and hsrs in cells of the mouse adrenocortical tumour y1 and an hsr in the human colon carcinoma colo320 contain amplified copies of the cellular oncogenes c-ki-ras and c-myc , respectively .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 106, 111 ] }
{ "id": "C0086661", "name": "c-myc", "pos": [ 200, 205 ] }
the three-dimensional structures of the transforming region of the product of the ej/t24 human bladder oncogene and of the c-ha ras-1 gene product have been calculated by using conformational energy calculations .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 89, 94 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 103, 111 ] }
the three-dimensional structures of the transforming region of the product of the ej/t24 human bladder oncogene and of the c-ha ras-1 gene product have been calculated by using conformational energy calculations .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 89, 94 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 128, 131 ] }
the gag- a-mulv genomes were very unstable in transformed fibroblasts leading to large secondary deletions in v-abl sequences .
organism_has_gene
{ "id": "C0000742", "name": "a-mulv", "pos": [ 9, 15 ] }
{ "id": "C0080279", "name": "v-abl", "pos": [ 110, 115 ] }
influenza a virus released by infected diploid human fibroblasts contains nearly equal amounts of two electrophoretic forms of the viral nucleocapsid protein np ( np1 and np2 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 47, 52 ] }
{ "id": "C1706141", "name": "np", "pos": [ 171, 173 ] }
identification of homologous regions in human immunodeficiency virus i gp41 and human mhc class ii beta 1 domain .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 40, 45 ] }
{ "id": "C0017349", "name": "mhc class ii", "pos": [ 86, 98 ] }
both physiological and pharmacological concentration ranges of gc increased the specific binding of 125i-labeled human ril-1 alpha to pbmcs .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 113, 118 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 119, 122 ] }
these data provide evidence in favor of the conclusion that biotin deficiency causes increases in the composition of some odd-chain fatty acids in humans , perhaps by the same mechanism that leads to odd-chain fatty acidemia in the inborn deficiency of the biotin-dependent enzyme propionyl-coa carboxylase .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 147, 153 ] }
{ "id": "C1415068", "name": "odd", "pos": [ 200, 203 ] }
we measured the levels of messenger rna of the human multidrug-resistance gene ( mdr1 ) in 25 urogenital tumors before chemotherapy .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 47, 52 ] }
{ "id": "C0376623", "name": "multidrug-resistance gene", "pos": [ 53, 78 ] }
we measured the levels of messenger rna of the human multidrug-resistance gene ( mdr1 ) in 25 urogenital tumors before chemotherapy .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 47, 52 ] }
{ "id": "C0376622", "name": "mdr1", "pos": [ 81, 85 ] }
structural characterization of the human platelet-derived growth factor a-chain cdna and gene : alternative exon usage predicts two different precursor proteins .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 35, 40 ] }
{ "id": "C1335200", "name": "platelet-derived growth factor a-chain", "pos": [ 41, 79 ] }
the human platelet-derived growth factor ( pdgf ) a-chain locus was characterized by restriction endonuclease analysis , and the nucleotide sequence of its exons was determined .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1335200", "name": "platelet-derived growth factor", "pos": [ 10, 40 ] }
a 13-kilobase ecori genomic restriction fragment containing the human c-fps/fes proto-oncogene locus was expressed transiently in cos-1 monkey cells and stably in rat-2 fibroblasts .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 64, 69 ] }
{ "id": "C0812383", "name": "fps/fes", "pos": [ 72, 79 ] }
in both cases , human c-fps/fes directed synthesis of a 92-kilodalton protein-tyrosine kinase ( p92c-fes ) indistinguishable from a tyrosine kinase previously identified with anti-fps antiserum which is specifically expressed in human myeloid cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 16, 21 ] }
{ "id": "C1708010", "name": "fps", "pos": [ 180, 183 ] }
the transforming human h-ras gene showed a point mutation in codon 61 that would result in leucine instead of the glutamine present in the normal gene product .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 17, 22 ] }
{ "id": "C0079471", "name": "h-ras gene", "pos": [ 23, 33 ] }
to understand better the role of gli in human neoplasia , we have now cloned the gli complementary dna ( cdna ) and determined its nucleotide sequence .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 40, 45 ] }
{ "id": "C0812304", "name": "gli", "pos": [ 81, 84 ] }
information about the timing of activation of the embryonic genome in the human is of relevance not only to the therapeutic practice of in vitro fertilization and embryo transfer ( ivf ) , but more importantly for the successful development of techniques for the preimplantation diagnosis of certain inherited genetic diseases .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 74, 79 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 181, 184 ] }
the human int-2 locus was found to be amplified 7- to 25-fold in 4 of 46 infiltrating ductal breast cancers and 30- to 60-fold in 2 of 8 squamous carcinomas of the head and neck region , but not in other cancers .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1708016", "name": "int-2", "pos": [ 10, 15 ] }
it is now shown that a large binding site for a protein antigen ( lysozyme ) can also be transplanted from mouse to human heavy chain .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 116, 121 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 122, 133 ] }
in two pairs of these sublines ( lovo human colon carcinoma and b16 mouse melanoma sublines ) , resistance to dx was induced in vitro , while in the third pair ( 9229 human metastatic melanoma clones ) , dx resistance was spontaneously present in clone 9229.24 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 38, 43 ] }
{ "id": "C0376622", "name": "dx", "pos": [ 204, 206 ] }
southern blot analysis of mouse-human somatic cell hybrids have localized the ltf gene to region q21 -- -- qter of human chromosome 3 ( teng et al. , unpublished data ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 32, 37 ] }
{ "id": "C1416933", "name": "ltf", "pos": [ 78, 81 ] }
we have investigated a panel of human lung cancer cell lines representing the major groups of lung cancer , i.e. , small-cell carcinoma ( scc ) and the group of non-scc , consisting of squamous-cell carcinoma ( sqc ) , adenocarcinoma ( adc ) and large-cell carcinoma ( lcc ) , for their expression of certain growth factor genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 32, 37 ] }
{ "id": "C0812325", "name": "growth factor genes", "pos": [ 309, 328 ] }
the effect of rtnf-alpha on human t cell function was examined and compared with that of ril-1 beta by assessing the ability of each cytokine to support mitogen-induced proliferation , il-2 production , and il-2r expression .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 28, 33 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 89, 92 ] }
this report investigates the effect of human platelet purified tgf-beta on csf-1-induced proliferation in liquid cultures .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 39, 44 ] }
{ "id": "C1366557", "name": "tgf-beta", "pos": [ 63, 71 ] }
inhibition of cfu-e and bfu-e by human and porcine tgf beta 1 was similar , ranging from 17 to 73 % over a concentration range of 0.05 to 1.0 ng/ml , and was largely independent of the type of burst-promoting activity used ( ril-3 vs cell line 5637-conditioned medium ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 33, 38 ] }
{ "id": "C1366557", "name": "tgf beta 1", "pos": [ 51, 61 ] }
inhibition of cfu-e and bfu-e by human and porcine tgf beta 1 was similar , ranging from 17 to 73 % over a concentration range of 0.05 to 1.0 ng/ml , and was largely independent of the type of burst-promoting activity used ( ril-3 vs cell line 5637-conditioned medium ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 33, 38 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 225, 228 ] }
in contrast , growth of cfu-gm stimulated by plateau concentrations of human rg-csf , rgm-csf , and ril-3 was enhanced up to 154 +/- 22 % by human tgf beta 1 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 71, 76 ] }
{ "id": "C1366557", "name": "tgf beta 1", "pos": [ 147, 157 ] }
about 30 % of human tumours contain a mutation in one of the three ras genes leading to the production of p21ras oncoproteins that are thought to make a major contribution to the transformed phenotype of the tumour .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 14, 19 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 109, 112 ] }
antiserum directed against the conserved retroviral protease active site was used to identify pol precursor and processed species containing the presumed protease domain .
organism_has_gene
{ "id": "C0035366", "name": "retroviral", "pos": [ 41, 51 ] }
{ "id": "C0017360", "name": "pol", "pos": [ 94, 97 ] }
thus , the pathogenic and the host range determinants of the feline aplastic anemia retrovirus colocalize to a 3 ' pol-5 ' env region of the fsc genome and likely reside within a region encoding 241 amino acid residues of the n terminus of the extracellular glycoprotein .
organism_has_gene
{ "id": "C0035366", "name": "retrovirus", "pos": [ 84, 94 ] }
{ "id": "C0017360", "name": "pol", "pos": [ 115, 118 ] }
thus , the pathogenic and the host range determinants of the feline aplastic anemia retrovirus colocalize to a 3 ' pol-5 ' env region of the fsc genome and likely reside within a region encoding 241 amino acid residues of the n terminus of the extracellular glycoprotein .
organism_has_gene
{ "id": "C0035366", "name": "retrovirus", "pos": [ 84, 94 ] }
{ "id": "C0017343", "name": "env", "pos": [ 123, 126 ] }
to study the digestion pattern of human high-molecular weight ( mol wt ) kininogen ( hmwk ) in plasma during contact activation we have prepared monoclonal antibodies ( moabs ) to the light-chain ( lc ) and the heavy-chain moiety of hmwk .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 34, 39 ] }
{ "id": "C1420192", "name": "heavy-chain", "pos": [ 211, 222 ] }
this report demonstrates that activated human alveolar macrophages express the gene for transforming growth factor-alpha ( tgf-alpha ) in an inducible manner and secrete a factor into the culture medium that is functionally and immunologically identical to tgf-alpha .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 40, 45 ] }
{ "id": "C1336620", "name": "gene", "pos": [ 79, 83 ] }
human p450pcn1 : sequence , chromosome localization , and direct evidence through cdna expression that p450pcn1 is nifedipine oxidase .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1705261", "name": "p450pcn1", "pos": [ 103, 111 ] }
these results suggest that a human p450 related to rat p450pcn1 is the major form of p450 catalyzing nifedipine oxidation .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 29, 34 ] }
{ "id": "C1705261", "name": "p450pcn1", "pos": [ 55, 63 ] }
the human homologue of the fission yeast schizosaccharomyces pombe cell cycle control gene cdc2 has been assigned to chromosome 10 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1707108", "name": "cdc2", "pos": [ 91, 95 ] }
studies of hla-dr expression on cultured human thyrocytes : effect of antithyroid drugs and other agents on interferon-gamma-induced hla-dr expression .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 41, 46 ] }
{ "id": "C1413237", "name": "gamma", "pos": [ 119, 124 ] }
tsh ( either bovine or human ) did not induce hla-dr expression on thyrocytes by itself , but did enhance ifn gamma-induced hla-dr expression in normal , but not gd , thyrocytes ;
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 23, 28 ] }
{ "id": "C1413237", "name": "ifn gamma", "pos": [ 106, 115 ] }
balb/c mice were sensitized to lethal effects of human rtnf-alpha and of human ril-1 alpha by simultaneous treatment with sublethal doses of actinomycin d ( act d ) or d-galactosamine ( galn ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 49, 54 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 79, 82 ] }
the availability of human rtnf-alpha , rifn-gamma , and ril-2 permitted evaluation of the role of each of these lymphokines/monokines , alone or in combination , in activating macrophages in vitro to kill mac .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 20, 25 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 56, 59 ] }
human monocyte-derived macrophages were cultured in vitro , stimulated with ril-2 , rifn-gamma , or rtnf , and then infected with mac ( serovars 1 and 8 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 76, 79 ] }
human ril-1 alpha and il-1 beta , synthetic lipid a , and lps were several orders of magnitude more potent than human rtnf .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 6, 9 ] }
in humans , three subregions , dp , dq , and dr , of the class ii genes as well as the dz alpha and do beta genes , have been extensively characterized .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 3, 9 ] }
{ "id": "C0017349", "name": "class ii genes", "pos": [ 57, 71 ] }
in human caudate and cortex membranes , [ 3h ] serotonin ( [ 3h ] 5-ht ) labels 5-ht1a and 5-ht1c recognition sites which show nanomolar affinity for 8-oh-dpat ( 8-hydroxy-2- ( di-n-propylamino ) -tetralin ) and mesulergine respectively , whereas no 5-ht1b binding could be identified .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 3, 8 ] }
{ "id": "C3538902", "name": "di", "pos": [ 260, 262 ] }
transfection of nih 3t3 cells with cdna clones containing either the entire coding sequences or the tyrosine protein kinase domain of the human trk protooncogene results in the frequent generation of transforming genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 138, 143 ] }
{ "id": "C0029016", "name": "transforming genes", "pos": [ 200, 218 ] }
here we test the capacity of concanavalin a , wheat germ agglutinin , human ril-1 and ril-2 , reagents which stimulate t cell activities in other species , to substitute for carrier priming in the newt .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 70, 75 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 86, 89 ] }
additionally , human ril-1 can serve as an effective substitute for carrier priming , but ril-2 can not .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 15, 20 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 90, 93 ] }
the cytofluorimetric data are in agreement with the functional data in that they suggest that human ril-2 may not bind newt splenocytes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 94, 99 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 100, 103 ] }
the ultrastructural features of 8 human cardiac myxomas were analyzed and correlated with immunohistochemical data , with the aim to clarify the characteristics of the cell lines involved in the tumor genesis .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 34, 39 ] }
{ "id": "C1414672", "name": "genesis", "pos": [ 201, 208 ] }
the activity of monocyte supernatant was greatly reduced by treatment with antiserum specific for human interleukin-1 beta ( il-1 beta ) , although a combination of ril-1 beta and ril-2 failed to stimulate ifn-gamma production in dr- lymphocytes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 98, 103 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 180, 183 ] }
abnormal or absent expression of the human retinoblastoma susceptibility ( rb ) gene has been implicated in the genesis of retinoblastoma .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 37, 42 ] }
{ "id": "C1414672", "name": "genesis", "pos": [ 112, 119 ] }
we show here that the substance could induce expression of activation markers on human lymphocytes ( 4f2 , hla-class ii antigens , thermostable se rosette formation ) and potentiate their appearance in combination with mitogens ( pwm , pha , con a ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 81, 86 ] }
{ "id": "C1420192", "name": "4f2", "pos": [ 101, 104 ] }
association of macrophage-derived factors with b2-microglobulin ( b2m ) antigen determinants was observed by inhibition with great antihuman b2m , affinity chromatography , and direct replacement of mouse macrophage-derived factors with human urinary b2m .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 135, 140 ] }
{ "id": "C1415587", "name": "b2m", "pos": [ 251, 254 ] }
the similarity of effects upon rat and human lymphocytes suggests that dbtc and dotc acts in the same manner in rat and man and offers the possibility of a therapeutic use of these compounds .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 39, 44 ] }
{ "id": "C3538902", "name": "dotc", "pos": [ 80, 84 ] }
a human easily sees that white , although it has one less pawn , can win the game by advancing its leftmost pawn across the board , whereupon it is promoted , by the rules of chess , to a queen .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 2, 7 ] }
{ "id": "C3538717", "name": "win", "pos": [ 69, 72 ] }
the cell lines used in the present study , panc-1 of human origin and two cell lines of hamster origin , wd paca and pd paca , exhibit primary or intrinsic doxorubicin resistance .
organism_has_gene
{ "id": "C0086418", "name": "human origin", "pos": [ 53, 65 ] }
{ "id": "C0376622", "name": "doxorubicin resistance", "pos": [ 156, 178 ] }
we show that purified human transforming growth factor-beta ( 1-10ng/ml ) inhibits interleukin 1-stimulated loss of proteoglycan from cartilage in vitro .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 22, 27 ] }
{ "id": "C1366557", "name": "transforming growth factor-beta", "pos": [ 28, 59 ] }
positions of introns are identical to those reported for the chicken progesterone receptor and the human oestrogen receptor genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 99, 104 ] }
{ "id": "C1414461", "name": "oestrogen receptor genes", "pos": [ 105, 129 ] }
in humans , lymphocyte-hev binding involves a lymphocyte surface glycoprotein ( gp ) of 85 to 95 kd ( cd44 , h-cam ) , defined by monoclonal antibody ( moab ) hermes-1 .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 3, 9 ] }
{ "id": "C1426009", "name": "hermes", "pos": [ 159, 165 ] }
polyclonal antibodies raised in rabbits against bacterially produced peptides in the c-terminal region of v-erb a or human c-erb a alpha oncogenes recognize the nuclear triiodothyronine ( t3 ) receptors in the t3-sensitive ob 17 mouse preadipocyte cell line and not in mouse or rat liver .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 117, 122 ] }
{ "id": "C0029016", "name": "oncogenes", "pos": [ 137, 146 ] }
the human c-ha-ras protooncogene product p21c was truncated at the c terminus by 23 amino acids .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 15, 18 ] }
these results suggests that in cultured human monocytes-macrophages , iron up-regulates trfr expression , thus in sharp contrast to the negative feedback reported in a variety of other cell types .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 40, 45 ] }
{ "id": "C1420708", "name": "trfr", "pos": [ 88, 92 ] }
apparent kms of 0.47 ( munag ) and 0.35 mmol/l ( mcpnag ) for human nag isoenzyme a and 0.46 ( munag ) and 0.30 mmol/l ( mcpnag ) for human nag isoenzyme b were determined .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 62, 67 ] }
{ "id": "C1709111", "name": "nag", "pos": [ 140, 143 ] }
experiments with hgh deletion constructs reveal that binding sites for transcription factor ap-2 and the pituitary-specific factor ghf-1 are not required for forskolin stimulation , but that ghf-1 may potentiate the effect .
organism_has_gene
{ "id": "C0086418", "name": "hgh", "pos": [ 17, 20 ] }
{ "id": "C1418759", "name": "ghf-1", "pos": [ 191, 196 ] }
conditioned medium was assayed with an enzyme immunoassay ( eia ) that utilizes a monoclonal antibody ( clone 27/21 ) against mouse beta-ngf , and contained 15 ng/ml of rhngf .
organism_has_gene
{ "id": "C0086418", "name": "rhngf", "pos": [ 169, 174 ] }
{ "id": "C1417719", "name": "rhngf", "pos": [ 169, 174 ] }
the rhngf migrated as a dimer of 26-29 kd on a gel permeation chromatography column , and stimulated neurite outgrowth and neuropeptide y mrna levels in pc12 cells .
organism_has_gene
{ "id": "C0086418", "name": "rhngf", "pos": [ 4, 9 ] }
{ "id": "C1417719", "name": "rhngf", "pos": [ 4, 9 ] }
the translational product of the dbl oncogene is a 66 kda ( p66 ) protein with no apparent sequence similarity to any of the known oncogene products , whereas the human dbl proto-oncogene encodes a translational product of 115 kda ( p115 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 163, 168 ] }
{ "id": "C0812211", "name": "dbl", "pos": [ 169, 172 ] }
when transferred to mitogen-deficient medium , myoblasts transfected with the valine-12 allele of the human harvey ( h ) -ras gene ceased dividing but failed to appropriately down-regulate vimentin and beta- , gamma-actin mrnas .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 102, 107 ] }
{ "id": "C0079471", "name": "h", "pos": [ 117, 118 ] }
in order to document a possible involvement of structural alterations of fgf ( fibroblast growth factor ) -like genes in human oncogenesis , we have screened a large series of human tumors for amplification of five fgf-related genes ( basic-fgf , int2 , hst , fgf5 and fgf6 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 121, 126 ] }
{ "id": "C0812290", "name": "int2", "pos": [ 247, 251 ] }
in order to document a possible involvement of structural alterations of fgf ( fibroblast growth factor ) -like genes in human oncogenesis , we have screened a large series of human tumors for amplification of five fgf-related genes ( basic-fgf , int2 , hst , fgf5 and fgf6 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 121, 126 ] }
{ "id": "C0919466", "name": "hst", "pos": [ 254, 257 ] }
the authors have localized elastase in human blood and bone marrow neutrophils by immunoelectron microscopy using a monoclonal anti-human elastase antibody ( np 57 ) and compared its distribution with myeloperoxidase ( mpo ) and lactoferrin ( lf ) , which mark primary and secondary neutrophil granule , respectively .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 39, 44 ] }
{ "id": "C1706141", "name": "np", "pos": [ 158, 160 ] }
in contrast to the human chain , the bovine form was not separable by sodium dodecyl sulfate-polyacrylamide gel electrophoresis/urea into the two distinct bands h1 and h2 and ran in parallel to the human h2 band .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 19, 24 ] }
{ "id": "C0919509", "name": "h2", "pos": [ 204, 206 ] }
the effector cells mediating this lysis include long term allospecific human ctl , and both human and mouse ctl clones recognizing mouse class i mhc kb ag .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 71, 76 ] }
{ "id": "C0017355", "name": "class i mhc", "pos": [ 137, 148 ] }
in order to study the in vitro and in vivo oncogenicity of n-ras and to compare its pathogenicity to that of h-ras , we have inserted an activated or a normal form of human n-ras cdna into a slightly modified harvey murine sarcoma virus-derived vector in which the h-ras p21 coding region had been deleted .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 167, 172 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 267, 270 ] }
in order to study the in vitro and in vivo oncogenicity of n-ras and to compare its pathogenicity to that of h-ras , we have inserted an activated or a normal form of human n-ras cdna into a slightly modified harvey murine sarcoma virus-derived vector in which the h-ras p21 coding region had been deleted .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 167, 172 ] }
{ "id": "C1705572", "name": "h-ras", "pos": [ 265, 270 ] }
we have screened a large series of primary human leukemias for activating point mutations at codons 12 , 13 and 61 of the n-ras and k-ras proto-oncogenes and at codons 12 and 61 of the h-ras proto-oncogene by using panels of oligonucleotide probes in conjunction with polymerase chain reaction gene amplification .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 43, 48 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 274, 277 ] }
we report here the cloning and sequencing of the human intestinal na+/glucose cotransporter ( sglt1 ) and compare its structure with other cloned transporters .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 49, 54 ] }
{ "id": "C1420200", "name": "sglt1", "pos": [ 94, 99 ] }
based on deduced amino acid sequences and patterns of hybridization of cdna and oligonucleotide probes with mammalian brain poly ( a ) + rna , human arf1 is the homologue of bovine arf1 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 143, 148 ] }
{ "id": "C1412504", "name": "arf1", "pos": [ 181, 185 ] }
human arf3 , which differs from bovine arf1 and bovine arf2 , appears to represent a newly identified third type of arf .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1412504", "name": "arf1", "pos": [ 39, 43 ] }
deduced amino acid sequences of human arf1 and arf3 contain regions , similar to those in other g proteins , that are believed to be involved in gtp binding and hydrolysis .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 32, 37 ] }
{ "id": "C1412504", "name": "arf1", "pos": [ 38, 42 ] }
oncogene activation in human benign tumors of the skin ( keratoacanthomas ) : is hras involved in differentiation as well as proliferation ?
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 23, 28 ] }
{ "id": "C0079471", "name": "hras", "pos": [ 81, 85 ] }
the activity of phosphotyrosyl-protein phosphatase enzyme was investigated by a histochemical method in the normal human breast and in breast diseases in order to evaluate its possible significance in the genesis and in the growth of benign and malignant epithelial proliferative .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 115, 120 ] }
{ "id": "C1414672", "name": "genesis", "pos": [ 205, 212 ] }
fibroblasts , expressing human ha- ras at high or a very low level , provide a biological model system to optimize in situ hybridization .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 25, 30 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 35, 38 ] }
the conformations of a truncated human c-ha-ras gene product [ ras ( 1-171 ) protein ] in the gdp-bound form and in the gtp gamma s-bound form were compared by two-dimensional nuclear overhauser effect spectroscopy ( noesy ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 33, 38 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 63, 66 ] }
alpha-acetoxy-n-nitrosodimethylamine , an activated derivative of the carcinogen n-nitrosodimethylamine , methylated in vitro a plasmid containing the human c-ha-ras-1 proto-oncogene , resulting in the generation of a transforming oncogene , assayed by transfection into nih 3t3 cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 151, 156 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 231, 239 ] }
these results demonstrate that a simple methylating agent can activate a normal human ras proto-oncogene to a transforming oncogene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 80, 85 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 86, 89 ] }
the human liver cytochrome p-450 ( p-450 ) proteins responsible for catalyzing the oxidation of mephenytoin , tolbutamide , and hexobarbital are encoded by a multigene family ( cyp2c ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1881502", "name": "cyp2c", "pos": [ 177, 182 ] }