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BioRel

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thus it would appear that there is a single human intestinal brush border peptide hydrolase capable of hydrolysing a variety of di- and tri-peptides .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 44, 49 ] }
{ "id": "C3538902", "name": "di", "pos": [ 128, 130 ] }
exposure of 32p-labelled human platelets to ionophore a23187 results in an increased incorporation of 32p into polypeptides with apparent mol.wts . of 47 000 ( p47 ) and 20 000 ( p20 ) , whereas exposure to prostaglandin e1 results in increased labelling of polypeptides with apparent mol.wts . of 24 000 ( p24 ) and 22 000 ( p22 ) [ haslam , lynham & fox ( 1979 ) biochem . j . 178 , 397-406 ] .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 25, 30 ] }
{ "id": "C1705714", "name": "wts", "pos": [ 289, 292 ] }
three anti-human milk fat globule membrane antibodies produced in our laboratory ( bc1 , bc2 , and bc3 ) were tested to determine their reactivity with these synthetic peptides .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 11, 16 ] }
{ "id": "C1538455", "name": "bc2", "pos": [ 89, 92 ] }
genetic recombination in human melanoma and astrocytoma cell lines involves oncogenes and growth factor genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 25, 30 ] }
{ "id": "C0029016", "name": "oncogenes", "pos": [ 76, 85 ] }
genetic recombination in human melanoma and astrocytoma cell lines involves oncogenes and growth factor genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 25, 30 ] }
{ "id": "C0812325", "name": "growth factor genes", "pos": [ 90, 109 ] }
the enzyme-linked immunosorbent assay is specific for mis , with a sensitivity in human serum to 0.5 ng/ml and does not recognize transforming growth factor-beta 1 or -beta 2 , lh , or fsh .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 82, 87 ] }
{ "id": "C1366557", "name": "transforming growth factor-beta 1", "pos": [ 130, 163 ] }
the human major histocompatibility complex contains approximately 20 class i genes , pseudogenes , and gene fragments .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0017355", "name": "class i", "pos": [ 69, 76 ] }
in addition we identified short ranges of conserved amino acid sequences within c-type retroviral gag and pol genes sufficient for phylogenetic analysis .
organism_has_gene
{ "id": "C0035366", "name": "retroviral", "pos": [ 87, 97 ] }
{ "id": "C0017360", "name": "pol genes", "pos": [ 106, 115 ] }
the human gene that confers human multidrug resistance , the mdr1 gene , has been cloned and classified as a member of the mdr gene family .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1704939", "name": "mdr1 gene", "pos": [ 61, 70 ] }
the human gene that confers human multidrug resistance , the mdr1 gene , has been cloned and classified as a member of the mdr gene family .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0376623", "name": "mdr gene", "pos": [ 123, 131 ] }
among the various stimuli used [ human ( h ) ril-1 alpha , hrtnf-alpha , hril-3 , hr-granulocyte-macrophage-csf , lps , fmlp , and platelet-activating factor ( paf ) ] only hril-1 alpha ( 100 u/ml ) and hrtnf-alpha ( 100 ng/ml ) induced the transcription and translation of nap/il-8 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 33, 38 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 174, 177 ] }
human ril-2 , expressed and purified from escherichia coli , is currently being tested as an anticancer therapeutic agent .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 6, 9 ] }
the alpha fc gamma r gene was also demethylated and expressed in mouse spleen cells cultured with human ril-2 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 98, 103 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 104, 107 ] }
the cyclosporin a-mediated inhibition of con-a stimulated lymphoblasts was , over a period of 5 days , largely abrogated by human ril-2 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 124, 129 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 130, 133 ] }
addition of human ril-2 did not overcome the inhibition of ctl generation , even when it was added daily to keep its level similar to that produced in a normal mlr .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 12, 17 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 18, 21 ] }
however , when day 5 csa-mlr cells generated in the absence of il-2 were washed and recultured with human ril-2 , there was a burst of ctl activity , with a more than 50-fold increase in alloantigen-specific cytotoxicity within 24 to 48 h .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 100, 105 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 106, 109 ] }
with the use of this protocol , it was shown that both human and mouse ril-6 , as well as mouse rtnf-alpha , potentiated dth in a dose-dependent manner .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 55, 60 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 71, 74 ] }
we show here that highly purified human t cells can respond directly in an antigen-specific manner to murine stimulating cells if human ril-1 or ril-2 or a t cell growth factor ( tcgf ) preparation are present in the culture .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 34, 39 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 145, 148 ] }
in this work , we have examined the hypothesis that the development of resistance to chemotherapy in neuroblastoma might be related to the expression of the human mdr1 gene , which encodes a multidrug transporter that functions as an energy-dependent drug efflux pump .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 157, 162 ] }
{ "id": "C0376622", "name": "mdr1", "pos": [ 163, 167 ] }
thyroid hormone regulates expression of a transfected human alpha-myosin heavy-chain fusion gene in fetal rat heart cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 54, 59 ] }
{ "id": "C1420192", "name": "heavy-chain", "pos": [ 73, 84 ] }
human primary germ cell tumors were analyzed for the presence of the ganglioside gm2 using three specific monoclonal antibodies which can distinguish the molecular species of the sialic acid moiety : the antibody mk1-16 is specific for n-acetyl gm2 , mk2-34 is specific for n-glycolyl gm2 , and mk1-17 detects both n-acetyl and n-glycolyl gm2 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1708816", "name": "mk1", "pos": [ 295, 298 ] }
the ras gene is one of the oncogenes most commonly detected in human cancers , and it consists of three families ( h-ras , k-ras , n-ras ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 63, 68 ] }
{ "id": "C1705572", "name": "h-ras", "pos": [ 115, 120 ] }
the ras gene is one of the oncogenes most commonly detected in human cancers , and it consists of three families ( h-ras , k-ras , n-ras ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 63, 68 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 133, 136 ] }
the ras gene is one of the oncogenes most commonly detected in human cancers , and it consists of three families ( h-ras , k-ras , n-ras ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 63, 68 ] }
{ "id": "C0809246", "name": "n-ras", "pos": [ 131, 136 ] }
human somatosensory evoked potentials to mechanical pulses and vibration : contributions of si and sii somatosensory cortices to p50 and p100 components .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1420622", "name": "sii", "pos": [ 99, 102 ] }
total proteins from a mouse embryo fibroblast cell line nih/3t3 , nih/3t3 cells transformed by human activated c-ha-ras ( ej-ras ) oncogene ( ej-nih/3t3 ) , and the two flat revertant cell lines , r1 and r2 , were analyzed by two-dimensional gel electrophoresis ( ief and nephge ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 95, 100 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 125, 128 ] }
the structure of the bola-dra and -dqa gene was found to be very similar to that of the corresponding human hla class ii genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 102, 107 ] }
{ "id": "C0017349", "name": "hla class ii genes", "pos": [ 108, 126 ] }
an analysis of the structure of the other class ii bola-a gene showed that this a gene was clearly very different from both the human a genes and the bovine dra and dqa genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 128, 133 ] }
{ "id": "C1335836", "name": "dra", "pos": [ 157, 160 ] }
since no clear homologue of this presumed bola-dya gene was found among the human hla class ii genes , these results indicate that , at least as far as the a genes are concerned , a distinct class ii gene is present in cattle .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 76, 81 ] }
{ "id": "C0017349", "name": "class ii gene", "pos": [ 191, 204 ] }
the identification of a tre immediately downstream of the last tgf-beta 1 exon suggests that a 3 ' enhancer may play an important role in human tgf-beta 1 gene transcription , and suggests a basis for growth factor-mediated regulation of tgf-beta 1 expression by activation of protein kinase c .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 138, 143 ] }
{ "id": "C1366557", "name": "tgf-beta 1 gene", "pos": [ 144, 159 ] }
two monoclonal antibodies ( mabs ) raised to synthetic human relaxin ( h2 ) gave different patterns of localization in the fetal membranes , decidua and placenta .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 55, 60 ] }
{ "id": "C0919509", "name": "h2", "pos": [ 71, 73 ] }
two human liver cdnas for p450s of the cyp2c subfamily designated iic8 and iic9 ( s .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1881502", "name": "cyp2c", "pos": [ 39, 44 ] }
these elements correspond to the conserved sequence elements found in other human and mouse class ii genes , the x box , the y box , and the h box .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 76, 81 ] }
{ "id": "C0017349", "name": "class ii genes", "pos": [ 92, 106 ] }
three gli binding sites were identified by using a novel procedure in which total human dna was bound to a gli recombinant fusion protein , and the polymerase chain reaction was used to amplify and recover the bound sequences .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 82, 87 ] }
{ "id": "C0812304", "name": "gli", "pos": [ 107, 110 ] }
here we show linkage between mhs and dna markers from the gpi region of human chromosome 19 with a maximum log likelihood ratio ( lod score ) of 5.65 at the cyp2a locus .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 72, 77 ] }
{ "id": "C1706116", "name": "cyp2a", "pos": [ 157, 162 ] }
previous experiments have demonstrated that transcription of the human c-fos oncogene is activated through the action of the 289-amino acid adenovirus e1a gene product .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 65, 70 ] }
{ "id": "C0087140", "name": "fos", "pos": [ 73, 76 ] }
when the cloning of the human gene for oct-2 revealed it to be a member of a distinct family of homeobox genes , we sought to determine if the human oct-2 cdna could be used to identify homologous chicken homeobox genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 24, 29 ] }
{ "id": "C0017347", "name": "homeobox genes", "pos": [ 205, 219 ] }
using a human oct-2 homeobox-specific dna probe , we were able to identify 6-10 homeobox-containing genes in the chicken genome , demonstrating that the oct-2-related subfamily of homeobox genes exists in avian species .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 8, 13 ] }
{ "id": "C0017347", "name": "homeobox genes", "pos": [ 180, 194 ] }
this in vitro system may be useful as a tool for dissecting the process of radiation-induced neoplastic transformation of human epithelial cells and for detecting previously unreported human oncogenes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 122, 127 ] }
{ "id": "C0029016", "name": "oncogenes", "pos": [ 191, 200 ] }
it was previously shown that the chromosome 19 breakpoint of the t ( 1 ; 19 ) ( q23 ; p13.3 ) translocation , found in human pre-b cell acute lymphoblastic leukemias , is within the e2a transcription factor gene on chromosome 19 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 119, 124 ] }
{ "id": "C0812327", "name": "transcription factor gene", "pos": [ 186, 211 ] }
in addition , we used for the standard solution nag from human placenta , with specificity corresponding to that of human urine , so that values obtained with the cnp-nag method and a p-nitrophenyl-nag method ( `` '' mei assay nag '' '' ) correlated almost completely ( r = 0.995 , n = 29 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 57, 62 ] }
{ "id": "C1709111", "name": "na", "pos": [ 48, 50 ] }
first , there was 89 % homology with the cdna for a protein whose amino-terminal end forms the amino terminus of the chimeric tyrosine kinase human oncogene , trk-2h .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 142, 147 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 148, 156 ] }
bs1 is bounded by 302 bp identical long terminal repeats ( ltrs ) , and it contains open reading frames with apparent amino acid sequence similarity to reverse transcriptase and other retroviral pol gene enzymes .
organism_has_gene
{ "id": "C0035366", "name": "retroviral", "pos": [ 184, 194 ] }
{ "id": "C0017360", "name": "pol gene", "pos": [ 195, 203 ] }
we expressed normal and activated human cellular ha-ras cdnas which encode 21,000-dalton polypeptides ( p21s ) in saccharomyces cerevisiae by their insertion into a 2 micron-based replicating plasmid vector under 3-phosphoglycerate kinase promoter control .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 34, 39 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 52, 55 ] }
we isolated and sequenced a human genomic-dna segment that is homologous to a portion of v-rel , the transforming gene of reticuloendotheliosis virus ( strain t ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 28, 33 ] }
{ "id": "C0035018", "name": "v-rel", "pos": [ 89, 94 ] }
we isolated and sequenced a human genomic-dna segment that is homologous to a portion of v-rel , the transforming gene of reticuloendotheliosis virus ( strain t ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 28, 33 ] }
{ "id": "C0029016", "name": "transforming gene", "pos": [ 101, 118 ] }
morphologic transformation of nih 3t3 mouse cells occurs upon transfection of these cells with large amounts ( greater than or equal to 10 micrograms ) of recombinant dna molecules carrying the normal human h-ras-1 proto-oncogene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 201, 206 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 209, 212 ] }
in 75 tumor biopsies , we found amplification of the human k-ras-2 locus in one carcinoma of the lung .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 53, 58 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 61, 64 ] }
under similar assay conditions the normal c-abl gene products , murine p150c-abl and human p145c-abl , lacked detectable kinase activity .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 85, 90 ] }
{ "id": "C1704928", "name": "abl", "pos": [ 116, 119 ] }
no activity was observed with normal chicken and human c-myc alleles , two other bursal lymphoma c-myc alleles ( ll3myc and ll6myc ) , and two human c-myc genes ( hsrmyc and dmmyc ) from human neuroectodermal tumor cell line colo320 , in which c-myc is amplified .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 49, 54 ] }
{ "id": "C0086661", "name": "c-myc", "pos": [ 244, 249 ] }
to address this question , we inserted the normal human c-ha-ras-1 or its mutated counterpart ej/t24 bladder carcinoma oncogene independently into a retrovirus vector derived from the m1 strain of moloney murine sarcoma virus ( momusv ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 50, 55 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 61, 64 ] }
to address this question , we inserted the normal human c-ha-ras-1 or its mutated counterpart ej/t24 bladder carcinoma oncogene independently into a retrovirus vector derived from the m1 strain of moloney murine sarcoma virus ( momusv ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 50, 55 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 119, 127 ] }
biological and morphological characteristics of phenotypic revertants appearing in interferon-treated mouse cells transformed by a human oncogene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 131, 136 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 137, 145 ] }
phenotypic revertants appearing in interferon-treated mouse cells that had been transformed by an activated human c-ha-ras1 oncogene ( cell line rs485 ) were tested for several biological properties .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 108, 113 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 124, 132 ] }
long-term cultures of k562 ( s ) cells in 50-75 microm hemin allow the selection of 'hemin-resistant ' k562 cells together with cells which proliferate efficiently while fully induced to express the human embryonic globin genes , as the hemoglobin gower 1 ( zeta 2 epsilon 2 ) is the predominant hemoglobin produced .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 199, 204 ] }
{ "id": "C3825351", "name": "globin genes", "pos": [ 215, 227 ] }
since most of the amino acid differences between mouse and human beta 2m probably correspond to externally oriented hydrophilic residues , these results suggest that critical interactions in the three-dimensional structure of hla class i molecules occur between the light chain and the first two external domains of the class i heavy chains , to which some of the altered reactivities have been mapped .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 59, 64 ] }
{ "id": "C1420192", "name": "heavy", "pos": [ 328, 333 ] }
the human apo-e gene has been isolated from a lambda phage library using as a probe the previously reported apo-e cdna clone pe-301 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1412481", "name": "apo-e gene", "pos": [ 10, 20 ] }
many human carcinomas accumulate a large quantity of glycolipids having x ( gal beta 1 -- -- 4 [ fuc alpha 1 -- -- 3 ] glcnac ) as well as di- or trimeric x determinant ( gal beta 1 -- -- 4 [ fuc alpha 1 -- -- 3 ] glcnac beta 1 -- -- 3gal beta 1 -- -- 4 [ fuc alpha 1 -- -- 3 ] glcnac beta 1 -- -- 3gal ) ( e.g . hakomori , s. , nudelman , e. , levery , s. b. , and kannagi , r. ( 1984 ) j. biol . chem . 259 , 4672-4680 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 5, 10 ] }
{ "id": "C3538902", "name": "di", "pos": [ 139, 141 ] }
in analogy to glycosylation and high antigenicity of envelope polypeptides of other mammalian retroviruses , gp 100 seemed to be related to the env gen .
organism_has_gene
{ "id": "C0035366", "name": "retroviruses", "pos": [ 94, 106 ] }
{ "id": "C0017343", "name": "env", "pos": [ 144, 147 ] }
one of these is a 300-base segment that is tightly conserved between mice and humans and is located at the 5 ' end of the zeta-globin gene .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 78, 84 ] }
{ "id": "C1704837", "name": "end", "pos": [ 111, 114 ] }
furthermore , the exon sizes and the locations of the exon-intron boundaries are identical in the human and chicken c-src genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 98, 103 ] }
{ "id": "C0038085", "name": "c-src genes", "pos": [ 116, 127 ] }
the results of this analysis indicate that , as in human burkitt lymphomas with the 8 ; 14 chromosome translocation , the c-myc gene is translocated to the heavy chain locus in mouse plasmacytomas .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 51, 56 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 156, 167 ] }
a previously proposed animal model of lysergic acid diethylamide 's ( lsd ) effects in humans was tested for its applicability to other hallucinogens , 2,5-dimethoxy-4-methyl amphetamine ( dom ) and n , n-dimethyltryptamine ( dmt ) .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 87, 93 ] }
{ "id": "C3539821", "name": "dom", "pos": [ 189, 192 ] }
pretreatment with the serotonin ( 5-ht ) antagonist cyproheptadine ( 1.0 mg/kg ) , which does not block the psychological effects of hallucinogens in humans , selectively blocked dom 's reduction of rearings without altering dom 's reduction of center entries , crossovers , or holepokes .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 150, 156 ] }
{ "id": "C3539821", "name": "dom 's", "pos": [ 225, 231 ] }
six human t cell lines hama , kun , kan , tcl-haz , tcl-ter , and tcl-mor , which were transformed by a retrovirus , human t-cell leukaemia virus ( htlv ) , constitutively produced plasminogen activators ( pas ) in culture supernatants .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1412532", "name": "tcl", "pos": [ 66, 69 ] }
cell lines ( colo 320 dm and colo 320 hsr ) , established from a human neuroendocrine tumor , contain an amplified cellular oncogene ( c-myc ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 65, 70 ] }
{ "id": "C0086661", "name": "c-myc", "pos": [ 135, 140 ] }
the value of the sperm speed measurements obtained from over 100 individuals in relation to fertility has been studied by the correlation of these results with human in vitro fertilization ( ivf ) data and sperm penetrating capability in the zona-free hamster egg assay .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 160, 165 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 191, 194 ] }
all 17 cysteine residues present in the human and bovine h chains are located at exactly equivalent positions , indicating that the human h chain , like the bovine counterpart , can form 8 loop structures , each connected by two adjacent cysteine residues .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 40, 45 ] }
{ "id": "C1420192", "name": "h chain", "pos": [ 138, 145 ] }
hla-a3- , hla-b7- , and hla-cw3-transfected l cells , maintained in medium supplemented with murine serum so as to ensure that the human heavy chains were associated with murine beta 2-microglobulin , were subjected to a systematic serologic analysis for an evaluation of the structural consequences of such an heterologous association .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 131, 136 ] }
{ "id": "C1420192", "name": "heavy chains", "pos": [ 137, 149 ] }
the w6/32 reactivity was restored after replacement of the murine by the human light chain , indicating that the conformation adopted by the hla class i heavy chain depends on the origin of the beta 2-microglobulin associated .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 73, 78 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 153, 164 ] }
in this investigation we have examined the effect of human interferon ( ifn ) type alpha on the ability of vaccinia virus to recombine within infected african green monkey kidney cells ( bsc-40 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 53, 58 ] }
{ "id": "C1420091", "name": "bsc", "pos": [ 187, 190 ] }
the sequence is compared with the hemagglutinin of two members of other subtypes , the human h2 strain a/jap/305/57 and the avian hav1 strain a/fpv/rostock/34 , and with one of the same h3 subtype , a/memphis/3/72 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 87, 92 ] }
{ "id": "C0919509", "name": "h2", "pos": [ 93, 95 ] }
partial n-terminal sequence analysis of each of the alpha components of the h-1a , h-11 and h-1n haplotypes yields a single , apparently homogeneous sequence which is identical among the three haplotypes and is strikingly homologous to the alpha polypeptides of the i-e subregion of mouse and to the human polypeptide , p34 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 300, 305 ] }
{ "id": "C1415345", "name": "p34", "pos": [ 320, 323 ] }
polymorphisms of dna restriction sites within the human fetal globin genes have been used to identify chromosomes that carry beta-thalassaemia genes in individuals heterozygous for this disease .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 50, 55 ] }
{ "id": "C3825351", "name": "globin genes", "pos": [ 62, 74 ] }
these data indicate that in human renovascular hypertension the juxtaglomerular apparatus is hyperplastic and hypergranulated : the correlation between its morphological appearance and pra seems to indicate that the renin-angiotensin system may be in some way involved in the genesis of hypertension .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 28, 33 ] }
{ "id": "C1414672", "name": "genesis", "pos": [ 276, 283 ] }
these 13 sera were further characterized after platelet absorption-elution , as well as by pretreatment with turkey anti-human-beta2-microglobulin serum .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 121, 126 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 127, 132 ] }
the fourth component of complement , c4 , was isolated from human serum in good yield , and in confirmation of previous reports was shown to be formed from three peptide chains , alpha , beta and gamma , with apparent mol.wts .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 60, 65 ] }
{ "id": "C1705714", "name": "wts", "pos": [ 222, 225 ] }
the expression of hla , human and mouse beta2-microglobulin ( beta2m ) , p red blood cell antigen and a receptor for marmoset red blood cells ( marbc ) were studied on 18 man/mouse and man/chinese hamster hybrids .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 24, 29 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 62, 67 ] }
we studied 3 hybrid clones where hla antigens are still expressed despite the absence of human beta2m and where redistribution experiments demonstrate that hla is associated with mouse beta2m .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 89, 94 ] }
{ "id": "C1417683", "name": "beta2m", "pos": [ 185, 191 ] }
in the supernatants from the 4-hour cultures of human hla-identical and hla-diferent lymphocytes beta2-microglobulin was determined by immunodiffusion and radioimmunologically .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 48, 53 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 97, 102 ] }
the intracellular distribution of human beta2-microglobulin was examined in human cell lines ( a burkitt lymphoma cell line , a b-lymphoid cell line and an epighelial-like cell line ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 34, 39 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 40, 45 ] }
a much smaller conformational alteration occurs under similar circumstances with the human lys-plasmin heavy chain .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 85, 90 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 103, 114 ] }
isolated normal human peripheral lymphocytes were analyzed for their ability to bind ige as shown by rosette formation with aldehydefixed ox red cells coated with an ige myeloma protein ( eo'-ige ) as indicator cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 16, 21 ] }
{ "id": "C1423498", "name": "coated", "pos": [ 151, 157 ] }
correlation of rat h2 and to human breath h2 measurements and flatus gas volumes were significant and positive except for negative correlation with flatus methane volume .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 29, 34 ] }
{ "id": "C0919509", "name": "h2", "pos": [ 42, 44 ] }
oncogenicity in marmosets of hl-23v , a type c oncornavirus isolated from human leukemic cells , and comparison with simian sarcoma virus type 1 ( ssv-1/ssav-1 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 74, 79 ] }
{ "id": "C0751995", "name": "ssv", "pos": [ 147, 150 ] }
the activity of leukocyte migration inhibitory factor ( lif ) obtained from sephadex-g-100-chromatographed supernatants of concanavalin-a-stimulated human lymphocytes was suppressed by two synthetic serine esterase and serine protease inhibitors ( di-isopropylfluorophosphate ( dfp ) and phenylmethylfulfonyl fluoride ( pmsf ) ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 149, 154 ] }
{ "id": "C3538902", "name": "di", "pos": [ 248, 250 ] }
the activity of leukocyte migration inhibitory factor ( lif ) obtained from sephadex-g-100-chromatographed supernatants of concanavalin-a-stimulated human lymphocytes was suppressed by two synthetic serine esterase and serine protease inhibitors ( di-isopropylfluorophosphate ( dep ) and phenylmethylsulfonyl fluoride ( pmsf ) ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 149, 154 ] }
{ "id": "C3538902", "name": "di", "pos": [ 248, 250 ] }
a plasminogen activator secreted by cultured human pancreatic carcinoma ( mia paca-2 ) cells has been purified to apparent homogeneity by procedures including sepharose-l-arginine methyl ester affinity chromatography , sephadex g-200 gel filtration , isoelectric focusing , and sodium dodecyl sulfate gel electrophoresis .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 45, 50 ] }
{ "id": "C1417154", "name": "mia", "pos": [ 74, 77 ] }
[ regional localization of the genes for human idhs , mdhs pgk , alphagal , g6pd by interspecific hybridization ( author 's transl ) ] .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 41, 46 ] }
{ "id": "C2697642", "name": "idhs", "pos": [ 47, 51 ] }
mitogenicity of anti-beta2m antibodies can therefore be ascribed to the antigen-binding site and not to the fc portion of the molecule .
organism_has_gene
{ "id": "C0086418", "name": "anti-beta2m", "pos": [ 16, 27 ] }
{ "id": "C1417683", "name": "anti-beta2m", "pos": [ 16, 27 ] }
the mitogenic response to f ( ab ' ) 2 , and sometimes fab , fragments of anti-beta2m igg was comparable to that obtained with original igg antibodies when tested at the same protein concentration .
organism_has_gene
{ "id": "C0086418", "name": "anti-beta2m", "pos": [ 74, 85 ] }
{ "id": "C1417683", "name": "anti-beta2m", "pos": [ 74, 85 ] }
since fab monomers of anti-beta2m can cause lymphocyte activation , 'cross-linking ' of hypothetical beta2-microblobulin-containing lymphocyte receptors does not seem necessary for activation .
organism_has_gene
{ "id": "C0086418", "name": "anti-beta2m", "pos": [ 22, 33 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 101, 106 ] }
f ( ab ' ) 2 , as well as fab , fragments of anti-beta2m blocked the cytotoxic effect of anti-beta2m igg , showing that the fragments did indeed react with beta2-microblobulin on the cell surface .
organism_has_gene
{ "id": "C0086418", "name": "anti-beta2m", "pos": [ 45, 56 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 156, 161 ] }
f ( ab ' ) 2 dimers , but not fab monomers , of anti-beta2m were capable of inhibiting the cytotoxic effect of an anti-hla-a2 antiserum .
organism_has_gene
{ "id": "C0086418", "name": "anti-beta2m", "pos": [ 48, 59 ] }
{ "id": "C1417683", "name": "anti-beta2m", "pos": [ 48, 59 ] }
the mitogenic activity of both anti-beta2m igg and fab monomers of such antibodies disappeared after absorption with highly purified beta2-microblobulin .
organism_has_gene
{ "id": "C0086418", "name": "anti-beta2m", "pos": [ 31, 42 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 133, 138 ] }
the mitogenic effect of anti-beta2m igg was inhibited to a minor extent by exposure of cells to high concentrations of pooled multispecific anti-hla antibodies .
organism_has_gene
{ "id": "C0086418", "name": "anti-beta2m", "pos": [ 24, 35 ] }
{ "id": "C1417683", "name": "anti-beta2m", "pos": [ 24, 35 ] }
a comparison of the mrnas for rabbit and human beta-hemoglobins shows that synonymous changes in codons have accumulated three times as rapidly as nucleotide replacements that produced changes in amino acids .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 41, 46 ] }
{ "id": "C1415481", "name": "beta-hemoglobins", "pos": [ 47, 63 ] }
human kidney extracts heated to 60 degrees and devoid of hexosaminidase activity ( 2-acetamido-2-deoxy-beta-d-glucoside acetamidodeoxyglucohydrolase ec 3.2.1.30 ) stimulate more than 20-fold the hexosaminidase a-catalyzed degradation of ganglioside gm2 and of glycolipid ga2 , the neuronal storage compounds of gm2 gangliosidosis .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1414471", "name": "ga2", "pos": [ 271, 274 ] }
selective antagonism of prostaglandin ( pg ) e1 , pgd2 and prostacyclin ( pgi2 ) on human and rabbit platelets by di-4-phloretin phosphate ( dpp ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 84, 89 ] }
{ "id": "C3538902", "name": "di", "pos": [ 114, 116 ] }
reactions of rabbit antisera to human beta2-m against human platelets and man-mouse hybrid cells were studied by ma tests and cytolysis tests .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 32, 37 ] }
{ "id": "C1417683", "name": "beta2-m", "pos": [ 38, 45 ] }