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BioRel

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human ril-4 specifically induces the expression of the low affinity receptor for ige ( fc epsilon r2/cd23 ) on normal b cells and on the burkitt lymphoma cell line jijoye .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 6, 9 ] }
the present study demonstrates that human ril-4 is capable of inducing the secretion of ige by pbmc .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 36, 41 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 42, 45 ] }
subcutaneous administration of hu ril-1 beta into immunodepressed animals immediately after carrier ( horse red blood cells , hrbc ) priming could restore to normal levels th cell activity .
organism_has_gene
{ "id": "C0086418", "name": "hu", "pos": [ 31, 33 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 34, 37 ] }
in parallel , the ability of spleen cells from hu ril-1 beta-treated immunodepressed animals to produce t cell growth factor activity upon in vitro mitogen stimulation was also increased significantly as compared to that of untreated mice and approached that of immunocompetent controls .
organism_has_gene
{ "id": "C0086418", "name": "hu", "pos": [ 47, 49 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 50, 53 ] }
it is reported here that both human ril-1 alpha and ril-1 beta totally inhibit the increases in ec rna synthesis , protein synthesis , and cell volumes induced by either tnf or lt .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 30, 35 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 52, 55 ] }
human peripheral blood mononuclear cells , activated for 14 to 20 days with 1000 u/ml ril-2 , develop strong cytotoxicity for nk sensitive and resistant targets .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 86, 89 ] }
cooperation in oncogenesis between bk virus early region gene and the activated human c-harvey ras oncogene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 80, 85 ] }
{ "id": "C0034678", "name": "ras oncogene", "pos": [ 95, 107 ] }
rapidly growing , undifferentiated brain tumours were induced in newborn syrian hamsters by intracerebral inoculation of a recombinant dna ( pbk/c-rasa ) carrying the bk virus ( bkv ) early region gene and the activated human c-harvey-ras ( c-ha-ras ) oncogene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 220, 225 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 246, 249 ] }
neither of the two genes inoculated alone nor recombinant dna of the bkv early region gene and the normal human c-ha-ras proto-oncogene were tumourigenic .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 106, 111 ] }
{ "id": "C0034678", "name": "c-ha-ras", "pos": [ 112, 120 ] }
inhibition studies of the nondopamine [ 3h ] haloperidol binding site in human cerebellar membranes revealed stereospecific binding and a pharmacological profile similar to that of specific sigma binding sites characterized in rodent brains using [ 3h ] haloperidol , n- [ 3h ] allylnormetazocine and di-o- [ 3h ] -tolylguanidine as radioligands .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 73, 78 ] }
{ "id": "C3538902", "name": "di", "pos": [ 335, 337 ] }
by clone-on-clone hybridization with known retroviruses of the hiv and siv groups , sivmnd showed similar cross-hybridization with hiv-1 , hiv-2 , sivagm ( african green monkey-derived siv ) , and sivmac ( rhesus macaque-derived siv ) in the gag and pol regions only at low stringency but not at high stringency , a result indicating that sivmnd is a new member of the hiv-siv group .
organism_has_gene
{ "id": "C0035366", "name": "retroviruses", "pos": [ 43, 55 ] }
{ "id": "C0017360", "name": "pol", "pos": [ 250, 253 ] }
a role for human heavy chain binding protein in the developmental regulation of immunoglobin transport .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 11, 16 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 17, 28 ] }
human ebv transformed lymphoblastoid cell lines and lymphomas representing various stages of b cell development were examined for heavy chain binding protein ( bip ) expression and its association with immunoglobin ( ig ) heavy chains .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 222, 233 ] }
we have previously shown that hamster h2t pancreatic ductal cancer has a receptor for vasoactive intestinal peptide ( vip ) which is not present on a cell line of human pancreatic ductal cancer ( mia ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 163, 168 ] }
{ "id": "C1417154", "name": "mia", "pos": [ 196, 199 ] }
molecular cloning , sequencing , and mapping of egr2 , a human early growth response gene encoding a protein with `` '' zinc-binding finger '' '' structure .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 57, 62 ] }
{ "id": "C0599295", "name": "early", "pos": [ 63, 68 ] }
using low-stringency hybridization with an egr-1 cdna probe , we identified a distinct human cdna ( designated egr2 for early growth response gene-2 ) , which is coregulated with egr1 by fibroblast and lymphocyte mitogens ;
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 87, 92 ] }
{ "id": "C1414315", "name": "early", "pos": [ 120, 125 ] }
using low-stringency hybridization with an egr-1 cdna probe , we identified a distinct human cdna ( designated egr2 for early growth response gene-2 ) , which is coregulated with egr1 by fibroblast and lymphocyte mitogens ;
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 87, 92 ] }
{ "id": "C1414314", "name": "egr1", "pos": [ 179, 183 ] }
strikingly , the deduced amino acid sequences of human egr2 and mouse egr-1 are 92 % identical in the zinc finger region but show no similarity elsewhere .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 49, 54 ] }
{ "id": "C1414315", "name": "egr2", "pos": [ 55, 59 ] }
strikingly , the deduced amino acid sequences of human egr2 and mouse egr-1 are 92 % identical in the zinc finger region but show no similarity elsewhere .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 49, 54 ] }
{ "id": "C1414314", "name": "egr-1", "pos": [ 70, 75 ] }
the coding region of the gene for the human beta 2-adrenergic receptor gene was fused to the beta-galactosidase gene of the lambda gt11 expression vector .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 38, 43 ] }
{ "id": "C1704463", "name": "beta 2-adrenergic receptor gene", "pos": [ 44, 75 ] }
angiotensin ii/iii and substance p in human follicular fluid obtained during ivf : relation of the peptide content with follicular size .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 38, 43 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 77, 80 ] }
the most upstream mrna start site is located at the 3'-end of the principal promoter , which lies directly adjacent to the homologous sequence between human and rat c-h-ras 5'-flanking regions .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 151, 156 ] }
{ "id": "C1705572", "name": "h-ras", "pos": [ 167, 172 ] }
moreover , computer analyses revealed that the intron sequences of various oncogenes ( both human and rodent sequences available from genbank dna sequence data-bank ) such as ras , fos , c-myc , n-myc and int-1 , are in general significantly more highly conserved when compared with sequences of non-oncogene introns .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 92, 97 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 175, 178 ] }
moreover , computer analyses revealed that the intron sequences of various oncogenes ( both human and rodent sequences available from genbank dna sequence data-bank ) such as ras , fos , c-myc , n-myc and int-1 , are in general significantly more highly conserved when compared with sequences of non-oncogene introns .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 92, 97 ] }
{ "id": "C0086661", "name": "c-myc", "pos": [ 187, 192 ] }
moreover , computer analyses revealed that the intron sequences of various oncogenes ( both human and rodent sequences available from genbank dna sequence data-bank ) such as ras , fos , c-myc , n-myc and int-1 , are in general significantly more highly conserved when compared with sequences of non-oncogene introns .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 92, 97 ] }
{ "id": "C0812287", "name": "n-myc", "pos": [ 195, 200 ] }
moreover , computer analyses revealed that the intron sequences of various oncogenes ( both human and rodent sequences available from genbank dna sequence data-bank ) such as ras , fos , c-myc , n-myc and int-1 , are in general significantly more highly conserved when compared with sequences of non-oncogene introns .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 92, 97 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 300, 308 ] }
we discuss here the possible role of vtr and allelic deletion of the c-ha-ras allele in primary human cancers in relation to c-ha-ras expression , and the usefulness of c-ha-ras rflp in the risk assessment of urothelial cancer .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 96, 101 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 174, 177 ] }
normal human fibroblasts , on the other hand , were not transformed into either immortal or tumorigenic cells by treatment with ha-msv or c-ha-ras alone .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 7, 12 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 143, 146 ] }
our laboratory is using the mouse embryonic cell line c3h10t1/2 to investigate cooperative transformation mediated by the activated human h-ras gene and several nuclear oncogenes from both viral and cellular sources .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 132, 137 ] }
{ "id": "C0079471", "name": "h-ras gene", "pos": [ 138, 148 ] }
the human isolates were identified as eubacterium cylindroides ( two strains , h1 and h2 ) , peptococcus niger ( two strains , h4 and h89 ) , and clostridium clostridiiforme .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0919509", "name": "h2", "pos": [ 86, 88 ] }
the hst1 protein is a heparin-binding growth factor with significant homology with human fibroblast growth factors and the mouse int-2 protein .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 83, 88 ] }
{ "id": "C1708016", "name": "int-2", "pos": [ 129, 134 ] }
characterization of two glycoproteins of human pancreatic juice : p35 , a truncated protease e and p19 , precursor of protein x .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 41, 46 ] }
{ "id": "C1704794", "name": "p35", "pos": [ 66, 69 ] }
dna extracted from fresh solid human melanoma tumors and untreated acute myeloid leukemic cells was used in two assays designed to detect oncogenes , based on the transfection of murine nih 3t3 fibroblasts followed by selection of transformed cells in low serum concentration or induction of tumors in athymic mice .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 31, 36 ] }
{ "id": "C0029016", "name": "oncogenes", "pos": [ 138, 147 ] }
the effects of in vivo treatment with recombinant human ifn-alpha 2a ( rifn-alpha 2a ) on the distribution of t cell subpopulations were examined in 21 patients with renal cell adenocarcinoma , using two-color flow cytometry with anti-leu8 in combination with anti-leu2 and anti-leu3 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 50, 55 ] }
{ "id": "C1333223", "name": "leu2", "pos": [ 265, 269 ] }
a novel human oncogene , lca , was assigned to region 2q14 -- -- q21 by in situ molecular hybridization .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 8, 13 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 14, 22 ] }
variants of human tissue-type plasminogen activator that lack specific structural domains of the heavy chain .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 12, 17 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 97, 108 ] }
we have examined 44 cases of human colonic and rectal carcinomas for structural rearrangement and amplification of c-myc , n-myc , l-myc , c-myb and p53 oncogenes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 29, 34 ] }
{ "id": "C0812287", "name": "n-myc", "pos": [ 123, 128 ] }
thus , at least in human colorectal malignancies , it is unlikely that nuclear oncogene structural alterations and/or amplification plays a major role in tumour induction or progression .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 19, 24 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 79, 87 ] }
human bronchial epithelial cells transformed by either dna virus infection ( sv40 or adenovirus 12-sv40 hybrid virus ) or transfection with the sv40 large t antigen gene were studied for their ability to undergo squamous differentiation when exposed to 12-o-tetradecanoylphorbol-13 acetate ( tpa ) , transforming growth factor-beta 1 ( tgf-beta 1 ) , or fetal bovine serum ( fbs ) , agents that induce the squamous differentiation of normal human bronchial epithelial cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1366557", "name": "transforming growth", "pos": [ 300, 319 ] }
these phenotypically different subclones provide a new in vitro cellular system for delineating the mechanism ( s ) of human bronchial epithelial cell squamous differentiation in response to fbs or tgf-beta 1 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 119, 124 ] }
{ "id": "C1366557", "name": "tgf-beta 1", "pos": [ 198, 208 ] }
the similarities in biochemical and cellular characteristics suggest that ly-10 is a mouse homologue of the human lymphocyte activation marker 4f2 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 108, 113 ] }
{ "id": "C1420192", "name": "4f2", "pos": [ 143, 146 ] }
we recently reported the cdna cloning , sequence , and expression of the human cation-independent mannose 6-phosphate receptor ( hci-mpr ) ( oshima , a. , nolan , c. m. , kyle , j. w. , grubb , j. h. , and sly , w. s. ( 1988 ) j. biol . chem . 263 , 2553-2562 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 73, 78 ] }
{ "id": "C1334090", "name": "cation-independent mannose 6-phosphate receptor", "pos": [ 79, 126 ] }
the sequence of the hci-mpr was virtually identical to that of the human insulin-like growth factor ii receptor cdna ( morgan , d. o. , edman , j. c. , standring , d. n. , fried , v. a. , smith , m. c. , roth , r. a. , and rutter , w. j . ( 1987 ) nature 329 , 301-307 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 67, 72 ] }
{ "id": "C1334090", "name": "insulin-like growth factor ii receptor", "pos": [ 73, 111 ] }
the expressed hci-mpr was localized in membranes including the plasma membrane , bound mannose 6-phosphate containing ligands , and mediated endocytosis which could be specifically blocked by mannose 6-phosphate .
organism_has_gene
{ "id": "C0086418", "name": "hci-mpr", "pos": [ 14, 21 ] }
{ "id": "C1334090", "name": "hci-mpr", "pos": [ 14, 21 ] }
we next measured the effect of the expressed hci-mpr on intracellular and secreted acid hydrolases .
organism_has_gene
{ "id": "C0086418", "name": "hci-mpr", "pos": [ 45, 52 ] }
{ "id": "C1334090", "name": "hci-mpr", "pos": [ 45, 52 ] }
human neutrophil ( pmn ) attachment to human umbilical vein endothelial cells ( huvec ) was evaluated in vitro using two mabs , r6-5-d6 and rr1/1 , that recognize intercellular adhesion molecule-1 ( icam-1 ) , and one mab , ts1/18 , that recognizes cd18 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1709827", "name": "rr1", "pos": [ 140, 143 ] }
both high- and low-affinity cell surface receptors that bound recombinant ( r ) il-1 alpha and beta with comparable affinities could be identified on cultured human keratinocytes , using 125i-labeled ril-1 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 159, 164 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 200, 203 ] }
laterality of several brain functions has been demonstrated in the human brain cortex as well as in several animal species indicating an evolutionary genesis of the brain 's asymmetry .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 67, 72 ] }
{ "id": "C1414672", "name": "genesis", "pos": [ 150, 157 ] }
pretreatment with zymosan opsonized with human ab serum , however , did not change the expression of other igg and c-binding sites such as fcrii ( examined with mab iv.3 and 2e1 ) and cr1 ( assessed with mab 57f ) as well as of unrelated cell membrane structures ( beta 2m , mhc class ii ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 41, 46 ] }
{ "id": "C0017349", "name": "mhc class ii", "pos": [ 275, 287 ] }
subsequent studies demonstrated that the contribution of faa could be partially replaced by the administration of several doses of human rifn-alpha a/d bg1 before the initiation of ril-2 administration .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 131, 136 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 181, 184 ] }
the bioactivity of the hybrid molecule was comparable to that of normal human ril-2 in assays measuring t cell proliferation , and in generation of lymphokine-activated killer cells from pbl .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 72, 77 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 78, 81 ] }
a gene encoding the h chain of the human class i mhc ag hla-b27 was introduced into the germ lines of inbred c57bl/6 ( b6 ) and non-inbred ( b6 x sjl/j ) f2 mice .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 35, 40 ] }
{ "id": "C0017355", "name": "class i mhc", "pos": [ 41, 52 ] }
the multi-csf activity in ra is not due to il-3 since human ril-3 was not active in either murine assay , and il-3 mrna was not detected in ra synovium .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 54, 59 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 60, 63 ] }
the 3'-terminal portion of the retroviral pol gene encodes a function required for the formation of the integrated provirus soon after infection of sensitive cells .
organism_has_gene
{ "id": "C0035366", "name": "retroviral", "pos": [ 31, 41 ] }
{ "id": "C0017360", "name": "pol gene", "pos": [ 42, 50 ] }
the r-erba alpha-2 cdna is most closely related to the human testicular c-erba alpha cdna .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 55, 60 ] }
{ "id": "C0242987", "name": "erba", "pos": [ 74, 78 ] }
in this study , using transient expression of chimeric reporter constructs , we document that the chick fibroblast c-erba-alpha and the human placental c-erba-beta modulate cis-acting regulatory sequences of two thyroid hormone responsive genes ;
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 136, 141 ] }
{ "id": "C0242988", "name": "erba-beta", "pos": [ 154, 163 ] }
none of the antibodies reacted with rat liver and brain or human liver t3 receptors , although one antibody did immunoprecipitate a human c-erba translated product .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 59, 64 ] }
{ "id": "C0242987", "name": "erba", "pos": [ 140, 144 ] }
triiodothyronine nuclear binding capacity in rat tissues correlates with a 6.0 kilobase ( kb ) and not a 2.6 kb messenger ribonucleic acid hybridization signal generated by a human c-erba probe .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 175, 180 ] }
{ "id": "C0242987", "name": "erba", "pos": [ 183, 187 ] }
monoclonal antibodies , 21w4 and 44h10 , against human mhc class ii determinants , were analysed for their reactivity with rabbit lymphoid cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 49, 54 ] }
{ "id": "C0017349", "name": "mhc class ii", "pos": [ 55, 67 ] }
comparison of this sequence with the human heavy chain subgroup iii shows homology of 78 % suggesting that a common ancestral variable region gene existed in mammals prior to speciation .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 37, 42 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 43, 54 ] }
through the combined use of this estimate and the number of nonsynonymous and synonymous substitutions per nucleotide site inferred from comparisons of entire human and rabbit hbbetamrna nucleotide sequences , we calculate ( a ) approximately 70 % of synonymous hbbeta mutations are adaptively undersirable and ( b ) the mutation rate underlying all changes is lesser than or equal to 10 ( -8 ) nucleotide substitutions per nucleotide site per year .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 159, 164 ] }
{ "id": "C1415481", "name": "hbbeta", "pos": [ 262, 268 ] }
the earlier finding that the o2 affinity of the llama hemoglobin is dependent on its content of 2 , 3-bisphosphoglycerate is interpreted here as a mutation of the 2 , 3-bisphosphoglycerate contact position beta2 his in human hemoglobin to beta2 asn in llama hemoglobin , whereby one of the four 2 , 3-bisphosphoglycerate contact points is interrupted .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 219, 224 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 239, 244 ] }
the effect is exemplified with e.g . blocking of human hla antibodies by anti-beta2-microglobulin from rabbits .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 49, 54 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 78, 83 ] }
supernatants from human tonsil cells cultured in the presence of the pbas , lps and f ( ab ) 2 monomers of rabbit anti-human beta2-microglobulin were found to have a complement-dependent cytotoxic activity to tonsil cells of the same donors .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 18, 23 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 125, 130 ] }
the finding that human myeloma is accompanied by elevated numbers of t cells with fc receptors for the heavy chain class of the myeloma protein : ( 1 ) may account for the apparent `` '' monoclonal '' '' lymphocyte population in patients with myeloma ;
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 17, 22 ] }
{ "id": "C1420192", "name": "heavy", "pos": [ 103, 108 ] }
the monoclonal antibody 3a1 defines a major human pb t cell subset ( 85 % of pb t cells ) while the antigen defined by the monoclonal antibody 4f2 is present on a subset ( 70 % ) of activated pb t cells and on circulating pb monocytes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 44, 49 ] }
{ "id": "C1420192", "name": "4f2", "pos": [ 143, 146 ] }
the rate of gtp hydrolysis by a form of p21 [ val12 ] encoded by a human oncogene was significantly lower ( 1.4-1.9 mmol/min per mol of p21 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 67, 72 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 73, 81 ] }
in situ hybridization of 125i-labeled human c-fos probe to normal human metaphase chromosomes independently confirmed these results and localized the c-fos oncogene to region 14q21 -- -- q31 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 38, 43 ] }
{ "id": "C0087140", "name": "fos", "pos": [ 152, 155 ] }
antibodies to a synthetic undecapeptide ( nh2-cys-glu-asn-pro-ser-gln-phe-tyr-glu-arg-leu-cooh ) , the sequence ( except cysteine ) of which was deduced from a previously reported cloned human retroviral gag-gene-related dna sequence erv-1 , were raised in rabbits .
organism_has_gene
{ "id": "C0035366", "name": "retroviral", "pos": [ 193, 203 ] }
{ "id": "C0017346", "name": "gag-gene", "pos": [ 204, 212 ] }
a modified technique for demonstration of acid alpha-naphthylacetate esterase was examined with regard to specificity and application on human t-lymphocytes in peripheral blood and pleural fluids of different genesis .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 137, 142 ] }
{ "id": "C1414672", "name": "genesis", "pos": [ 209, 216 ] }
human malignant tumours of the breast , as compared to their respective normal tissue , have elevated expression of the harvey ras oncogene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C0034678", "name": "ras oncogene", "pos": [ 127, 139 ] }
we have analyzed the organization and expression of the immunoglobulin heavy and light chain gene in the human myeloblastic leukemic sublines , ml1 , ml2 , and ml3 , and in the human myeloid leukemic cell lines , hl-60 , u937 , thp1 , and k562 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 105, 110 ] }
{ "id": "C0812306", "name": "thp1", "pos": [ 228, 232 ] }
human dna sequences homologous to a protein coding region conserved between homeotic genes of drosophila .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C0017347", "name": "homeotic genes", "pos": [ 76, 90 ] }
the cells of one clone , a549-c12 , were consistently negative for hsag , but their lamellar bodies were similar in appearance and distribution to those found in a pap-positive clone , a549-c11 , as well as in a549 cells .
organism_has_gene
{ "id": "C0086418", "name": "hsag", "pos": [ 67, 71 ] }
{ "id": "C0812382", "name": "a pap", "pos": [ 162, 167 ] }
human in vitro fertilization ( ivf ) , embryo culture ( ec ) , and embryo transfer ( et ) are commonly performed in various media supplemented with blood serum .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 31, 34 ] }
low doses of thrombin which produced only shape change in human platelets also caused significant formation of ip2 and ip3 but not ip .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 58, 63 ] }
{ "id": "C2697645", "name": "ip2", "pos": [ 111, 114 ] }
coexpression of the human hla-a2 or hla-b7 heavy chain gene and human beta 2-microglobulin gene in l cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 20, 25 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 43, 54 ] }
to test whether the absence of human beta 2-m was the cause of the lack of recognition by the human cytotoxic t lymphocytes , coexpression of the human beta 2-m gene and the hla-a2 or hla-b7 heavy chain in l cells ( `` '' double transfectants '' '' ) was obtained .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 31, 36 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 191, 202 ] }
we have constructed a chimeric retrovirus genome containing ecotropic gag-pol sequences from moloney murine leukemia virus and envelope sequences derived from the amphotropic virus 4070a .
organism_has_gene
{ "id": "C0035366", "name": "retrovirus", "pos": [ 31, 41 ] }
{ "id": "C0017360", "name": "pol", "pos": [ 74, 77 ] }
dna sequencing within the clone and comparisons with other retroviruses revealed that erv3 contains gag and pol gene sequences that are significantly related to those of mammalian type c retroviruses and previously described human endogenous proviruses .
organism_has_gene
{ "id": "C0035366", "name": "retroviruses", "pos": [ 59, 71 ] }
{ "id": "C0017360", "name": "pol gene", "pos": [ 108, 116 ] }
antigenic analysis of human and avian h2 influenza viruses were done with monoclonal antibodies to the ha molecules in hemagglutination inhibition ( hi ) assays .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 22, 27 ] }
{ "id": "C0919509", "name": "h2", "pos": [ 38, 40 ] }
the genetic complexity of the human class ii alpha and beta loci , as revealed by analysis with cdna and genomic clones , is greater than that of the murine class ii genes .
organism_has_gene
{ "id": "C0086418", "name": "genetic", "pos": [ 4, 11 ] }
{ "id": "C0017349", "name": "class ii genes", "pos": [ 157, 171 ] }
sensitivity of human pancreatic carcinoma cell line ( mia paca-2 ) to bisantrene and theprubicin in vitro .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 15, 20 ] }
{ "id": "C1417154", "name": "mia", "pos": [ 54, 57 ] }
we tested the effect of bisantrene ( bs ) and theprubicin ( thp-adr ) on cell growth of a human pancreatic carcinoma cell line ( mia paca-2 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 90, 95 ] }
{ "id": "C1417154", "name": "mia", "pos": [ 129, 132 ] }
elutions of radiolabeled np 's from both matrices show that hybrid dimers can form between major bovine np 's ( i and ii , or vldv- and msel-np 's , respectively ) , as well as between human and bovine np 's , with affinities close to that for homologous dimer formation .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 185, 190 ] }
{ "id": "C1706141", "name": "np 's", "pos": [ 202, 207 ] }
the human protooncogene nras and the genes for the beta-subunit of nerve growth factor ( ngfb ) and for amylase ( amy ) have previously been assigned to the proximal short arm of chromosome 1 , but their precise positions have not been unequivocally established .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0027260", "name": "nras", "pos": [ 24, 28 ] }
the results of this investigation indicate that neurofilaments of mammals ( human and rabbit ) are composed of four protofilaments each of which is formed of globular units connected by longitudinal bars .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 76, 81 ] }
{ "id": "C1707156", "name": "bars", "pos": [ 199, 203 ] }
the following 125i-labelled preparations of human and chicken haptoglobins ( hph , hpc ) and their complexes with human and chicken haemoglobins ( hph-hbh , hpc-hbc , hph-hbc ) were injected intravenously to chickens .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 44, 49 ] }
{ "id": "C2697529", "name": "hbh", "pos": [ 151, 154 ] }
nude mice injected subcutaneously with csf-producing human pancreatic carcinoma ( mia paca-2 ) cells developed tumors accompanied by a rise in serum csf activity , granulocytosis , and expanded marrow granulocyte pools , the extent of all of which correlated with tumor size .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 53, 58 ] }
{ "id": "C1417154", "name": "mia", "pos": [ 82, 85 ] }
four human class ii molecules , one fa , one dc1 , and two dr-like molecules , were isolated from dr2 and drw6 homozygous cell lines by means of a variety of monoclonal antibodies and were compared with each other by two-dimensional ( 2-d ) gel electrophoresis .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 5, 10 ] }
{ "id": "C1415570", "name": "dc1", "pos": [ 45, 48 ] }
the present data strongly support our previous hypothesis that hpgp , a 39 residue glycopeptide isolated from human neurohypophysis , may be part of the precursor of arginine-vasopressin and its neurophysin ii ( pro-np-avp ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 110, 115 ] }
{ "id": "C1706141", "name": "np", "pos": [ 216, 218 ] }
these results imply that breath testing can be used to determine the capacity for intestinal sugar absorption in humans and demonstrate that prior sugar malabsorption may affect the breath h2 response to a meal .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 113, 119 ] }
{ "id": "C0919509", "name": "h2", "pos": [ 189, 191 ] }
a point mutation is responsible for the acquisition of transforming properties by the t24 human bladder carcinoma oncogene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 90, 95 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 114, 122 ] }
thus , a single amino acid substitution appears to be sufficient to confer transforming properties on the gene product of the t24 human bladder carcinoma oncogene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 130, 135 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 154, 162 ] }
molecular cloning and chromosomal mapping of a human locus related to the transforming gene of moloney murine sarcoma virus .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 47, 52 ] }
{ "id": "C0029016", "name": "transforming gene", "pos": [ 74, 91 ] }
the hybrids were studied for the expression of human immunoglobulin chains and human isozyme markers , for the presence of human chromosomes , and for the presence of the human genes for heavy chain variable regions ( vh ) and mu and gamma chain constant ( c ) regions .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 47, 52 ] }
{ "id": "C1420192", "name": "heavy", "pos": [ 187, 192 ] }
as a result of southern blot hybridization of a c-sis probe to dna 's from mouse-human somatic cell hybrids , the human homolog ( c-sis ) of the transforming gene of simian sarcoma virus was assigned to chromosome 22 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 81, 86 ] }
{ "id": "C0751995", "name": "c-sis", "pos": [ 130, 135 ] }
as a result of southern blot hybridization of a c-sis probe to dna 's from mouse-human somatic cell hybrids , the human homolog ( c-sis ) of the transforming gene of simian sarcoma virus was assigned to chromosome 22 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 81, 86 ] }
{ "id": "C0037207", "name": "transforming gene", "pos": [ 145, 162 ] }
serum-free conditioned medium prepared from an established line of human pancreatic carcinoma ( mia paca-2 ) provides a rich source of colony-stimulating factor ( csf ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 67, 72 ] }
{ "id": "C1417154", "name": "mia", "pos": [ 96, 99 ] }
human light chain molecules were secreted as part of hybrid h2l2 molecules formed with mouse heavy chains .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1420192", "name": "heavy chains", "pos": [ 93, 105 ] }