text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
lymphocytes failed to induce permeability changes in vesicles containing other inserted proteins obtained from human nonextraocular muscle , liver , spleen , or adrenal , even if tg or tga were present . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
111,
116
]
} | {
"id": "C2699751",
"name": "tga",
"pos": [
185,
188
]
} |
moreover , some genetic factor or process in the tetraploid mouse erythroleukemia cell is , under the conditions of our experiments , capable of reactivating phenotypic expression ( production of globin chains ) of human globin genes derived from nonerythroid hematopoietic cells after chromosome-dependent gene transfer . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
215,
220
]
} | {
"id": "C3825351",
"name": "globin",
"pos": [
221,
227
]
} |
after the reduction of cytoplasmic atp in human platelets , the 31p nmr spectra showed an almost complete loss of the nucleoside di- and triphosphate resonances at temperatures examined ( 4 -- 50 degrees c ) , indicating that only the cytoplasmic nucleotides had been observed , with no detectable contributions from the granular atp , adp , and pyrophosphate . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
42,
47
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
212,
214
]
} |
we describe a solid-phase enzyme immunoassay for ferritin in human serum , with use of a horseradish peroxidase-labeled antibody and a highly sensitive chromogen , 2,2'-azino-di ( 3-ethyl-benzthiazoline-6-sulfonate ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
61,
66
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
175,
177
]
} |
anti-human beta2-microglobulin was used in an effort to `` '' map '' '' the location of the bw4 and bw6 antigenic determinants on the hla molecule . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
5,
10
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
11,
16
]
} |
evidence for aberrant control of proto-oncogenes in human malignancies was obtained when chromosomal translocations in burkitt 's lymphomas and chronic myelogenous leukaemia localized to the myc and abl cellular oncogenes , respectively . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
52,
57
]
} | {
"id": "C0080279",
"name": "abl",
"pos": [
199,
202
]
} |
examples of the method 's clinical application are the staging of human neuroblastomas and the evaluation of oncogene amplification , which has prognostic value for both overall survival and relapse time in breast cancer patients . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
66,
71
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
109,
117
]
} |
the apolipoprotein gene cluster on human chromosome 19 ( apoc1 , apoc2 , apoe ) has been localised by pulsed-field gel electrophoresis to within 200 kb of a chronic lymphocytic leukemia-associated translocation breakpoint . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
35,
40
]
} | {
"id": "C1412475",
"name": "apoc1",
"pos": [
57,
62
]
} |
nucleotide sequence analysis revealed that the hox-3.3 gene represents the murine cognate of the human homeobox gene c8 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
97,
102
]
} | {
"id": "C0017347",
"name": "homeobox gene",
"pos": [
103,
116
]
} |
moreover , the two soluble b7 forms , which differ only in their alpha 3 domain , are similarly recognized by monoclonal antibodies w6/32 ( anti-hla-abc ) , bbm.1 ( anti-human beta 2 microglobulin ) , and allo-b7-antibody , but differentially recognized by monoclonal antibody q1/28 ( anti-hla class i heavy chain ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
170,
175
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
302,
313
]
} |
normal human mammary epithelial cells ( hmec ) from different individual reduction mammoplasty specimens were all growth inhibited , and showed a flattened , elongated morphology in response to human recombinant transforming growth factor beta 1 ( tgf beta ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
7,
12
]
} | {
"id": "C1366557",
"name": "recombinant transforming growth factor",
"pos": [
200,
238
]
} |
the gene spans 2.83 kilobase pairs and has a three-exon/two-intron structure that is similar to the organization of the human 2,3-bisphosphoglycerate mutase gene ( joulin , v. , garel , m.-c. , leboulch , p. , valentin , c. , rosa , r. , rosa , j. , and cohen-solal , m. ( 1988 ) j. biol . chem . 263 , 15785-15790 ) , in that the second introns of both genes are localized precisely at the same position . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
120,
125
]
} | {
"id": "C1708995",
"name": "second",
"pos": [
331,
337
]
} |
when added to human pbl , purified nksf preparations induce ifn-gamma production and synergize with ril-2 in this activity , augment the nk cell-mediated cytotoxicity of pbl preparations against both nk-sensitive and nk-resistant target cell lines , and enhance the mitogenic response of t cells to mitogenic lectins and phorbol diesters . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
14,
19
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
100,
103
]
} |
retroviral packaging cell lines were constructed by using the gag-pol gene of spleen necrosis virus , the gag-pol gene of moloney murine leukaemia virus and the env gene of bovine leukaemia virus . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
0,
10
]
} | {
"id": "C0017346",
"name": "gag",
"pos": [
106,
109
]
} |
retroviral packaging cell lines were constructed by using the gag-pol gene of spleen necrosis virus , the gag-pol gene of moloney murine leukaemia virus and the env gene of bovine leukaemia virus . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
0,
10
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
110,
113
]
} |
retroviral packaging cell lines were constructed by using the gag-pol gene of spleen necrosis virus , the gag-pol gene of moloney murine leukaemia virus and the env gene of bovine leukaemia virus . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
0,
10
]
} | {
"id": "C0017343",
"name": "env gene",
"pos": [
161,
169
]
} |
antisense methylphosphonate-modified oligomers ( onmp ) complementary to 8 nucleotides spanning the twelfth amino acid codon of human c-ha-ras have been synthesized to explore their inhibitory effect on ras p21 translation . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
128,
133
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
203,
206
]
} |
the human class ii gene , hla-dr alpha , contains an octanucleotide sequence atttgcat located approximately 40 base pairs upstream of the transcription initiation site . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0017349",
"name": "class ii gene",
"pos": [
10,
23
]
} |
normal human hematopoietic progenitor cells were exposed to three different c-abl sense or antisense oligodeoxynucleotides , and the effects on myeloid and erythroid colony formation were examined . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
7,
12
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
78,
81
]
} |
dnas from 37 human gastric carcinomas and seven lymph node metastases were analyzed for alterations of the epidermal growth factor receptor ( egfr ) gene and oncogenes by the southern blot hybridization method . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
13,
18
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
158,
167
]
} |
an antibody directed against a synthetic oligopeptide corresponding to the amino-acid sequence ( glu-393-lys-408 ) of p-glycoprotein from human mdr1 cdna was prepared in rabbits . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
138,
143
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
144,
148
]
} |
isolation of a human cyclin cdna : evidence for cyclin mrna and protein regulation in the cell cycle and for interaction with p34cdc2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
15,
20
]
} | {
"id": "C1707108",
"name": "p34cdc2",
"pos": [
126,
133
]
} |
a genetic study has been made of the hiv tat gene from sequential hiv-1 isolates and the corresponding infected peripheral blood mononuclear cells . | organism_has_gene | {
"id": "C0019682",
"name": "hiv",
"pos": [
37,
40
]
} | {
"id": "C0017375",
"name": "tat gene",
"pos": [
41,
49
]
} |
type analysis of oligosaccharide chains on human and murine mhc class ii alpha chains by the lectin-nitrocellulose sheet method . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
43,
48
]
} | {
"id": "C0017349",
"name": "mhc class ii",
"pos": [
60,
72
]
} |
five new human hox-2 homeoboxes , termed hox-2.5 , 2.4 , 2.6 , 2.7 and 2.8 , have been identified , and their nucleotide sequences are reported . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
9,
14
]
} | {
"id": "C3541286",
"name": "hox-2.5",
"pos": [
41,
48
]
} |
when placed downstream of the poly ( a ) site of the human alpha 2-globin gene , the spa is used exclusively . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
53,
58
]
} | {
"id": "C2697530",
"name": "alpha 2-globin gene",
"pos": [
59,
78
]
} |
we have shown that mcm1 binds to the human c-fos sre in vitro and , like other mces , the c-fos sre exhibits mcm1-mediated upstream activating sequence ( uas ) activity in vivo . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
37,
42
]
} | {
"id": "C1420400",
"name": "mcm1",
"pos": [
109,
113
]
} |
three other human chromosome 11-encoded antigens , 4f2 ( trop-4 ) , leu 7 ( hnk-1 , cd57 ) , and lymphocyte homing receptor , were expressed concordantly with cd59 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
12,
17
]
} | {
"id": "C1420192",
"name": "4f2",
"pos": [
51,
54
]
} |
the mouse and the human apolipoprotein e genes were homologous in the 5 ' proximal flanking region up to about 200 nucleotides as well as in the four exons . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C1412481",
"name": "apolipoprotein e genes",
"pos": [
24,
46
]
} |
we synthesized peptides corresponding to amino acid residues , glu393-lys408 ( anti-p ) and leu1206-thr1226 ( anti-c ) in p-glycoprotein from human mdr1 cdna and used these peptides to produce polyclonal antibodies . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
142,
147
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
148,
152
]
} |
rac1 and rac2 cdna clones were isolated from a differentiated hl-60 library and encode proteins that are 92 % homologous and share 58 % and 26-30 % amino acid homology with human rhos and ras , respectively . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
173,
178
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
188,
191
]
} |
a full length human ral cdna was isolated from a placental cdna library , and its deduced amino acid sequence , compared with simian ral , also contained the asp -- -- glu substitution along with two other substitutions and an additional three nh2-terminal amino acids . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
14,
19
]
} | {
"id": "C0812284",
"name": "ral",
"pos": [
133,
136
]
} |
these results identify two new gtp-binding proteins in human platelets , ral , the major protein that binds [ alpha-32p ] gtp on nitrocellulose transfers , and rac1 , a substrate for botulinum c3 adp-ribosyltransferase . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
55,
60
]
} | {
"id": "C0812284",
"name": "ral",
"pos": [
73,
76
]
} |
these results identify two new gtp-binding proteins in human platelets , ral , the major protein that binds [ alpha-32p ] gtp on nitrocellulose transfers , and rac1 , a substrate for botulinum c3 adp-ribosyltransferase . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
55,
60
]
} | {
"id": "C1419227",
"name": "rac1",
"pos": [
160,
164
]
} |
human serum and albuminar 5 ( a5 ) were compared as medium supplements to earle 's solution containing pyruvate in clinical ivf . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
124,
127
]
} |
these findings demonstrate that tgf-beta 2 is as effective as tgf-beta 1 in inhibiting human b cell function , that small amounts of active tgf-beta 1 are present endogenously in in vitro cultures which partially inhibit b cell function , that two major tgf-beta 1 r cross-linked complexes of 65 and 90 kda are present on normal b cells , and that transformation of b cells may be accompanied by changes in the tgf-beta 1 r . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
87,
92
]
} | {
"id": "C1366557",
"name": "tgf-beta 1",
"pos": [
411,
421
]
} |
to investigate the role of ras p21 product expression in human hepatocellular carcinoma ( hcc ) , we have localized ras p21 in formalin fixed , paraffin-embedded normal and abnormal livers utilizing the avidin-biotin peroxidase method and a monoclonal antibody to ras-gene product p21 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
57,
62
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
264,
267
]
} |
the optimal dose for human rtnf alpha was 100 ng/ml and for ril-1 alpha and ril-1 beta , 1 ng/ml . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
21,
26
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
76,
79
]
} |
thus , compared with retroviruses , it is unlikely that hbv reverse transcriptase is translated from complete pol orf in the full-length pregenomic rna . | organism_has_gene | {
"id": "C0035366",
"name": "retroviruses",
"pos": [
21,
33
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
110,
113
]
} |
orf2 showed more substantial homology to retroviral pol genes and particularly to the analogs of pol found in a subclass of mobile dnas that are supposed retrotransposons , such as mammalian long interspersed repetitive sequences , drosophila i factors , silkworm r1 elements , and trypanosome ingi elements . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
41,
51
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
97,
100
]
} |
the human mdr ( p-glycoprotein ) gene family is known to include two members , mdr1 and mdr2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
79,
83
]
} |
the human mdr ( p-glycoprotein ) gene family is known to include two members , mdr1 and mdr2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1412071",
"name": "mdr2",
"pos": [
88,
92
]
} |
the human mdr locus was mapped by field-inversion gel electrophoresis , and both mdr genes were found to be linked within 330 kilobases . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0376623",
"name": "mdr genes",
"pos": [
81,
90
]
} |
the expression patterns of the human mdr genes were examined by enzymatic amplification of cdna . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
31,
36
]
} | {
"id": "C0376623",
"name": "mdr genes",
"pos": [
37,
46
]
} |
the human bcl-2 gene is a oncogene candidate which is involved in the t ( 14 ; 18 ) translocation specifically associated with follicular and diffuse b cell lymphomas . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
26,
34
]
} |
however , when compared to sequences previously reported for human c-fgr derived from ebv-transformed b cells and heterogeneous peripheral blood cells , the c-fgr cdna derived from normal murine monocytic cells differed significantly in sequence from amino acids 12-62 in the amino terminal domain of the protein which may mediate the substrate specificity and subcellular location of the src family of protein-tyrosine kinases . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
61,
66
]
} | {
"id": "C0919478",
"name": "c-fgr",
"pos": [
157,
162
]
} |
we evaluated the in-vitro interaction of normal human eosinophil leucocytes and a virulent strain of entamoeba histolytica ( hm1-imss ) in the presence of immune serum . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C1705014",
"name": "hm1",
"pos": [
125,
128
]
} |
two of three expressed human beta-globin mrna at levels per gene copy of 179.2 and 387.1 % . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
23,
28
]
} | {
"id": "C1705846",
"name": "at",
"pos": [
46,
48
]
} |
antibody reagents were made specific for each of the two forms of human sc , fsc and bsc , which is an integral part of the siga molecule . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
66,
71
]
} | {
"id": "C1420091",
"name": "bsc",
"pos": [
85,
88
]
} |
human bronchial epithelial cells can also be employed to investigate the role of specific oncogenes in carcinogenesis and tumor progression . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
90,
99
]
} |
thus , there are regional differences in the quantity of beta adrenoceptors in human myocard whereas the relative proportion of beta1 and beta2 receptors appears to be fairly constant . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
79,
84
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
138,
143
]
} |
the duplicated human embryonic alpha-like globin genes encode a 5 ' functional zeta ( xi 2 ) gene and a highly homologous pseudogene ( psi xi 1 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
15,
20
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
42,
54
]
} |
in human and mouse , the organization of the class iii genes is similar with respect to order and position between the class ii and class i regions of the mhc . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
3,
8
]
} | {
"id": "C0017355",
"name": "class i",
"pos": [
132,
139
]
} |
an ssti fragment of 2.9 kb carrying all four coding exons of the human melanoma c-ha-ras-1 oncogene could not transform mouse nih 3t3 cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
65,
70
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
85,
88
]
} |
an ssti fragment of 2.9 kb carrying all four coding exons of the human melanoma c-ha-ras-1 oncogene could not transform mouse nih 3t3 cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
65,
70
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
91,
99
]
} |
this work describes the determination of cbf in eight normal human subjects with positron emission tomographic ( pet ) imaging using the continuous intravenous infusion of h2 ( 15 ) o . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
61,
66
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
172,
174
]
} |
the cloning and expression of human il-1 genes will expand our understanding of il-1 in various diseases through improved detection systems and the use of cdna probes ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
30,
35
]
} | {
"id": "C1708431",
"name": "il-1 genes",
"pos": [
36,
46
]
} |
these data suggest that chromosomal analysis of unfertilized oocytes in human ivf may improve the understanding human oocyte maturation and fertilization . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
72,
77
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
78,
81
]
} |
primary human t-lymphocytes that have been mitogen activated in chemically defined medium demonstrate cell surface receptor for insulin-like growth factor-ii ( igf-ii ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C1334090",
"name": "receptor",
"pos": [
115,
123
]
} |
northern blot analysis using probes specific for each of the human embryonic ( epsilon ) , fetal ( gamma ) , and adult ( beta ) globin genes indicates that the human lymphoblastoid f-265 cells express the embryonic and fetal globin genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
61,
66
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
225,
237
]
} |
together , these findings suggest an enlarging role for myc-related genes in human lung cancer and provide evidence for the concept of a myc family of proto-oncogenes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
77,
82
]
} | {
"id": "C0919472",
"name": "myc family",
"pos": [
137,
147
]
} |
in order to obtain molecular clones of these cross-hybridizing fragments , we constructed lambda and cosmid libraries of human dna and screened them at low stringency with the hla-dr alpha gene specific subclone . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
121,
126
]
} | {
"id": "C1415575",
"name": "hla-dr alpha gene",
"pos": [
176,
193
]
} |
human dna segments homologous to the ets region from the transforming gene of avian erythroblastosis virus , e26 , were molecularly cloned and shown to be closely related to the viral equivalent by hybridization and partial sequence analysis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C0029016",
"name": "transforming gene",
"pos": [
57,
74
]
} |
we conclude that the ets sequence shared by the virus , the chicken , and humans is likely to contain at least two dissociable functional domains , ets-1 and ets-2 . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
74,
80
]
} | {
"id": "C0812201",
"name": "ets-1",
"pos": [
148,
153
]
} |
antigenic analysis of human and avian h2 influenza virus was carried out with monoclonal antibodies to the ha molecules of h2 influenza viruses isolated in the early stage of an h2 pandemic . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
22,
27
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
178,
180
]
} |
several human oncogenes identified in tumors and established cell lines have been cloned and studied in great detail using gene transfer techniques . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
14,
23
]
} |
in the cricopharyngeal part of the inferior constrictor in the human and canine pharynx , there is a group of odd muscle fibers ( transversal portion ) , which contracts at every phase of sigh . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
63,
68
]
} | {
"id": "C1415068",
"name": "odd",
"pos": [
110,
113
]
} |
incubation of human factor ix with human alpha-thrombin resulted in a time and enzyme concentration-dependent cleavage of factor ix yielding a molecule composed of a heavy chain ( mol wt 50,000 ) and a doublet light chain ( mol wt 10,000 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
14,
19
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
166,
177
]
} |
thus , the nih/3t3 transfection assay frequently detects activated n-ras oncogenes in human leukemias , while other transforming genes , distinct from the ras gene family , can be detected in some leukemias by the transfection assay . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
86,
91
]
} | {
"id": "C0029016",
"name": "transforming genes",
"pos": [
116,
134
]
} |
thus , the nih/3t3 transfection assay frequently detects activated n-ras oncogenes in human leukemias , while other transforming genes , distinct from the ras gene family , can be detected in some leukemias by the transfection assay . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
86,
91
]
} | {
"id": "C1335597",
"name": "ras gene family",
"pos": [
155,
170
]
} |
the rb susceptibility gene located in chromosomal region 13q14 apparently represents one of a class of recessive human cancer genes that can be contrasted to known oncogenes that function following amplification , aberrant insertion , or base substitutions at key sites within their gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
113,
118
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
164,
173
]
} |
we have determined the complete nucleotide sequence of a human dna fragment of approximately 13 kbp , which was shown by southern blot analysis to contain the entire v-fes/fps cellular homolog . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
57,
62
]
} | {
"id": "C1708010",
"name": "fps",
"pos": [
172,
175
]
} |
the deduced amino acid sequence has a molecular weight of 93 390 dalton resembling ncp92 , the recently described human c-fes/fps product . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
114,
119
]
} | {
"id": "C1708010",
"name": "fps",
"pos": [
126,
129
]
} |
human plasma retinol binding protein ( rbp ) is coded by a single gene and is specifically synthesized in the liver . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1419320",
"name": "plasma retinol binding protein",
"pos": [
6,
36
]
} |
we have characterized a lambda clone , from a human dna library , carrying the gene coding for plasma rbp . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
46,
51
]
} | {
"id": "C1419320",
"name": "plasma rbp",
"pos": [
95,
105
]
} |
the sites examined near the human delta- and beta-globin genes in transformed cells were not methylated . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
28,
33
]
} | {
"id": "C3825351",
"name": "globin",
"pos": [
50,
56
]
} |
phagocytosis of e. coli , k. pneumoniae , proteus vulgaris and enterobacter cloacae by human polymorphonuclear neutrophil was more enhanced in the presence of 1 mic and 1/2 mic for 6059-s than for cefazolin at 4 and 6 hours after incubation . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
87,
92
]
} | {
"id": "C1335222",
"name": "1 mic",
"pos": [
159,
164
]
} |
retroviral dna injected into rsv ( -- ) cells directed transcription of envelope mrna , which was then able to complement the rsv ( -- ) env deficiency and promote the production of infectious transforming virus . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
0,
10
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
137,
140
]
} |
human b-cell alloantigens dc1 , mt1 , and lb12 are identical to each other but distinct from the hla-dr antigen . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1415570",
"name": "dc1",
"pos": [
26,
29
]
} |
we have used normal diploid human skin fibroblasts , monkey bsc cells , and mouse l or 3t6 cells with almost equal efficiency . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
28,
33
]
} | {
"id": "C1420091",
"name": "bsc",
"pos": [
60,
63
]
} |
`` `` reversion '' '' and reacquisition of function can be controlled by removing or adding back a chromatographically purified product of a human interleukin 2 gene ( ril 2 ) that appears to serve , either directly or indirectly , as a lysis-inducing signal for these ctl . | organism_has_gene | {
"id": "C0086418",
"name": "a hum",
"pos": [
139,
144
]
} | {
"id": "C1335621",
"name": "( r",
"pos": [
166,
169
]
} |
the levels of type iii and type i collagen mrna levels were compared in control and sarcoma virus-transformed murine cell lines , as well as in nih 3t3 cells transformed by members of the human ras oncogenes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
188,
193
]
} | {
"id": "C0034678",
"name": "ras oncogenes",
"pos": [
194,
207
]
} |
nih 3t3 cells transformed with two human ras oncogenes showed decreased levels of alpha2 ( i ) and alpha1 ( iii ) mrnas . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
35,
40
]
} | {
"id": "C0034678",
"name": "ras oncogenes",
"pos": [
41,
54
]
} |
human c-src sequences homologous to the entire v-src region are present in a 20-kilobase region that contains 11 exons as determined by restriction mapping studies utilizing hybridization to labeled dna probes representing various subregions of the v-src gene and by preliminary dna sequencing analyses . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C0038085",
"name": "v-src gene",
"pos": [
249,
259
]
} |
the results indicate that , like the human oncogene , the harvey murine sarcoma virus-borne ras gene owes its oncogenic capacity to point mutations in coding sequences rather than to the alteration in transcriptional control that occurred when the formerly cellular ras sequences were acquired by the virus . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
37,
42
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
43,
51
]
} |
the results indicate that , like the human oncogene , the harvey murine sarcoma virus-borne ras gene owes its oncogenic capacity to point mutations in coding sequences rather than to the alteration in transcriptional control that occurred when the formerly cellular ras sequences were acquired by the virus . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
37,
42
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
266,
269
]
} |
proviral dna of arv-2 ( 9737 base pairs ) has long terminal repeat structures ( 636 base pairs ) and long open reading frames encoding gag ( 506 codons ) , pol ( 1003 codons ) , and env ( 863 codons ) genes . | organism_has_gene | {
"id": "C0035366",
"name": "arv-2",
"pos": [
16,
21
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
156,
159
]
} |
proviral dna of arv-2 ( 9737 base pairs ) has long terminal repeat structures ( 636 base pairs ) and long open reading frames encoding gag ( 506 codons ) , pol ( 1003 codons ) , and env ( 863 codons ) genes . | organism_has_gene | {
"id": "C0035366",
"name": "arv-2",
"pos": [
16,
21
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
182,
185
]
} |
human erythrocytes in suspension acquire gangliosides containing di- and trisialosyl residues added to the maintenance medium . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
121,
123
]
} |
the deduced genetic structure is unique : it shows , in addition to the retroviral gag , pol , and env genes , two novel open reading frames we call q and f . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
72,
82
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
89,
92
]
} |
the deduced genetic structure is unique : it shows , in addition to the retroviral gag , pol , and env genes , two novel open reading frames we call q and f . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
72,
82
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
99,
102
]
} |
structure of a functional rabbit class i mhc gene : similarity to human class i genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
66,
71
]
} | {
"id": "C0017355",
"name": "class i",
"pos": [
72,
79
]
} |
by using murine-human recombinant ifn-gamma hybrid molecules , the h1/h2 epitope was shown to depend on the amino-terminus of ifn-gamma , whereas the h21/h22 epitope was formed by the carboxy-terminal amino acid sequence . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
16,
21
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
154,
156
]
} |
the process is remarkably similar to that used by retroviruses such as rous sarcoma virus ( rsv ) to produce pr180gag-pol . | organism_has_gene | {
"id": "C0035366",
"name": "retroviruses",
"pos": [
50,
62
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
118,
121
]
} |
unique allelic restriction fragments of the human ha-ras locus in leukocyte and tumour dnas of cancer patients . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
53,
56
]
} |
in burkitt 's lymphoma , which carries the t ( 8 ; 14 ) chromosome translocation , the c-myc oncogene normally located on band q24 of human chromosome 8 ( refs 1-3 ) translocates to the heavy-chain locus on chromosome 14 ( refs 1 , 4 , 5 ) ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
134,
139
]
} | {
"id": "C1420192",
"name": "heavy-chain",
"pos": [
186,
197
]
} |
effects of two major activating lesions on the structure and conformation of human ras oncogene products . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
77,
82
]
} | {
"id": "C0034678",
"name": "ras oncogene",
"pos": [
83,
95
]
} |
to investigate how these subtle alterations exert such profound effects on the biologic activities of these genes , we studied structural and conformational properties of human ras-oncogene-encoded 21-kda proteins ( p21s ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
171,
176
]
} | {
"id": "C0034678",
"name": "ras-oncogene",
"pos": [
177,
189
]
} |
dna probes for pre-pro-epidermal growth factor ( egf ) and the precursor of the beta subunit of nerve growth factor ( ngf ) were used to chromosomally map human and mouse egf and ngf genes in panels of human-mouse and mouse-chinese hamster somatic cell hybrids . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
155,
160
]
} | {
"id": "C0812325",
"name": "ngf genes",
"pos": [
179,
188
]
} |
human major histocompatibility complex class i antigens : residues 61-83 of the hla-b7 heavy chain specify an alloreactive site . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
87,
98
]
} |
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