text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
we have used recombinant dna probes for the human jh , c mu , and c gamma immunoglobulin gene loci to analyze the genetic events associated with heavy chain gene expression in human b cells clonally transformed by epstein-barr virus . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
145,
156
]
} |
overall , the observed rearrangements and deletions of heavy chain constant region genes suggest that human heavy chain class switching proceeds in a general order consistent with the proposed order of the heavy chain gene classes along chromosome 14 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
102,
107
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
206,
217
]
} |
one antiserum was made against a polypeptide overlapping the in vivo tyrosine phosphorylation site of murine p120gag-abl and what is believed to be a homologous tyrosine phosphorylation site of the predicted normal human c-abl gene product ( v-abl 263-280 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
215,
220
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
244,
247
]
} |
one antiserum was made against a polypeptide overlapping the in vivo tyrosine phosphorylation site of murine p120gag-abl and what is believed to be a homologous tyrosine phosphorylation site of the predicted normal human c-abl gene product ( v-abl 263-280 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
215,
220
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
242,
247
]
} |
the detection of these enzymatically active human c-abl gene products is a rare observation which may be in part attributed to the c-abl gene translocation from chromosomes 9 to 22 occurring in the vast majority of chronic myelogenous leukemia patients . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
133,
136
]
} |
anti-htebg was titrated using protein a-sepharose which quantitatively binds igg and therefore bound [ 3h ] dht-htebg-anti-tebg complexes . | organism_has_gene | {
"id": "C0086418",
"name": "htebg",
"pos": [
5,
10
]
} | {
"id": "C1366439",
"name": "tebg",
"pos": [
123,
127
]
} |
human t-cell leukemia virus type i ( htlv-i ) , a family of human retrovirus and the predicted causative agent of human adult t-cell leukemia/lymphoma ( atl ) consists of the gag , pol , env , and px regions ( 1 ) . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
66,
76
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
181,
184
]
} |
human t-cell leukemia virus type i ( htlv-i ) , a family of human retrovirus and the predicted causative agent of human adult t-cell leukemia/lymphoma ( atl ) consists of the gag , pol , env , and px regions ( 1 ) . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
66,
76
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
187,
190
]
} |
the most striking feature of these retroviruses is the existence of a long open reading frame ( lor ) located at the 3 ' side of the provirus between the right end of the 3 ' side of env gene and the left end of the long terminal repeat ( ltr ) . | organism_has_gene | {
"id": "C0035366",
"name": "retroviruses",
"pos": [
35,
47
]
} | {
"id": "C0017343",
"name": "env gene",
"pos": [
183,
191
]
} |
these retroviruses appear to harbour a gag precursor-cleaving protease , a not yet experimentally identified viral protein , between their gag and pol genes . | organism_has_gene | {
"id": "C0035366",
"name": "retroviruses",
"pos": [
6,
18
]
} | {
"id": "C0017360",
"name": "pol genes",
"pos": [
147,
156
]
} |
the transforming gene of the abelson murine leukaemia virus , v-abl , contains two open reading frames ( orf ) . | organism_has_gene | {
"id": "C0000742",
"name": "abelson murine leukaemia virus",
"pos": [
29,
59
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
62,
67
]
} |
the complementary dna clone has been used to analyse a panel of human-mouse and human -- hamster somatic cell hybrid dnas and localize the prealbumin gene to chromosome 18 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
64,
69
]
} | {
"id": "C1421224",
"name": "prealbumin gene",
"pos": [
139,
154
]
} |
human cdnas from both class i and class ii gene products were used as probes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C0017349",
"name": "class ii gene",
"pos": [
34,
47
]
} |
the criminal sanction as it relates to human reproduction : the genesis of the statutory prohibition of abortion . | organism_has_gene | {
"id": "C0086418",
"name": "human reproduction",
"pos": [
39,
57
]
} | {
"id": "C1414672",
"name": "genesis",
"pos": [
64,
71
]
} |
the proteins investigated are human fibrinopeptide a , guinea pig insulin , rattlesnake cytochrome c , ms2 phage coat protein , rabbit triosephosphate isomerase , bovine pancreatic deoxyribonuclease a , bovine glutamate dehydrogenase , and bacillus thermoproteolyticus thermolysin . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
30,
35
]
} | {
"id": "C1423498",
"name": "coat protein",
"pos": [
113,
125
]
} |
on the basis of these results , ultrasonically guided puncture of follicles for collection of human oocytes in our ivf-et program seems suitable for use in all cases where laparoscopy is presently used and , moreover , in cases with severe adhesions , where laparoscopy may fail . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
94,
99
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
115,
118
]
} |
these sequences represent the entire v-abl human cellular homologue , are colinear with the viral v-abl transforming gene , and contain a minimum of seven intervening sequences . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
43,
48
]
} | {
"id": "C0080279",
"name": "v-abl transforming gene",
"pos": [
98,
121
]
} |
in addition to the major c-abl human locus , three regions of human dna sequence , corresponding to only portions of the v-abl gene , have been identified . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
31,
36
]
} | {
"id": "C0080279",
"name": "v-abl gene",
"pos": [
121,
131
]
} |
two of these have been molecularly cloned and shown to be distinct from the primary human c-abl locus . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
84,
89
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
92,
95
]
} |
these findings identify and map a single genetic locus of human dna , c-abl , representing the complete v-abl homologue , and demonstrate the existence of additional human dna sequences corresponding to more limited , subgenomic regions of v-abl . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
58,
63
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
240,
245
]
} |
crystals of human plasma retinol-binding protein have been obtained from 4.5 m-nacl buffered at ph 6.8 with 20 mm-cacodylate . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
12,
17
]
} | {
"id": "C1419320",
"name": "plasma retinol-binding protein",
"pos": [
18,
48
]
} |
while most abpc 's and bls 's contain integrated a-mulv proviral genome and synthesize the v-abl rna , most abpl 's do not . | organism_has_gene | {
"id": "C0000742",
"name": "a-mulv",
"pos": [
49,
55
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
91,
96
]
} |
the nucleotide sequence of the t24 human bladder carcinoma oncogene was determined , and the coding and noncoding sequences of the genome were identified . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
35,
40
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
59,
67
]
} |
their haemagglutinins ( ha ) were mainly related to avian ha , but also to the human ha h2 and to the swine ha hswl . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
79,
84
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
88,
90
]
} |
in several b-lymphoblastoid cell lines and in human peripheral blood lymphocytes the electrophoretic mobility of the 32p-labelled hla-a , b , c heavy chains consistently differed from that of molecules labelled by other means . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
46,
51
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
144,
156
]
} |
identification of human t-cell leukemia-lymphoma virus offers the clearest view to date of the role played by a virus in the etiology of human cancer : it may induce malignancy by activating homologous cellular genes following integration with host-cell dna . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C0029016",
"name": "malignancy",
"pos": [
166,
176
]
} |
the human cellular homologue , c-myc , located on human chromosome 8 , region q24 leads to qter ( refs 1 , 2 ) , is translocated into the immunoglobulin heavy-chain locus on human chromosome 14 ( ref . 3 ) in burkitt 's lymphoma , suggesting that c-myc has a primary role in transformation of some human haematopoietic cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
247,
252
]
} |
the complete nucleotide sequence of the c-fos ( human ) gene , the human cellular homolog of the oncogene ( v-fos ) of finkel-biskis-jinkins murine osteosarcoma virus , has been determined . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
97,
105
]
} |
the complete nucleotide sequence of the c-fos ( human ) gene , the human cellular homolog of the oncogene ( v-fos ) of finkel-biskis-jinkins murine osteosarcoma virus , has been determined . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C0087140",
"name": "v-fos",
"pos": [
108,
113
]
} |
nucleotide sequence analysis of human c-myc locus , chicken homologue , and myelocytomatosis virus mc29 transforming gene reveals a highly conserved gene product . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
32,
37
]
} | {
"id": "C0029016",
"name": "transforming gene",
"pos": [
104,
121
]
} |
furthermore , attempts will be made to identify the dna sequences which are responsible for transformation of the cv-1 cells according to the protocols that were applied recently for the isolation of human transforming genes [ 5-7 ] . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
200,
205
]
} | {
"id": "C0029016",
"name": "transforming",
"pos": [
206,
218
]
} |
chromosome mapping of human cell surface molecules : monoclonal anti-human lymphocyte antibodies 4f2 , a3d8 , and a1g3 define antigens controlled by different regions of chromosome 11 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
22,
27
]
} | {
"id": "C1420192",
"name": "4f2",
"pos": [
97,
100
]
} |
data from six hybrids containing three different regions of chromosome 11 indicate that it is the long arm of chromosome 11 which is both necessary and sufficient for expression of the human antigen defined by 4f2 while the antigen ( s ) defined by a3d8 and a1g3 map to short arm . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
185,
190
]
} | {
"id": "C1420192",
"name": "4f2",
"pos": [
210,
213
]
} |
a v-myc probe , containing sequences from the 3 ' domain of the gene , hybridized to single human hindiii and mouse ecori genomic dna fragments of the cellular myc genes whose segregation could be followed in interspecies somatic cell hybrids . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
92,
97
]
} | {
"id": "C0026902",
"name": "myc genes",
"pos": [
160,
169
]
} |
native human lmw kininogen is a single-chain ( glyco- ) protein of molecular weight 68,000 , which is converted to a two-chain protein by limited proteolysis with tissue kallikrein to form a heavy chain ( mr 62,000 ) and a light chain ( mr 4,000 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
7,
12
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
191,
202
]
} |
the discovery that human blood vessels possess h2 receptors as well as h1 receptors is discussed with particular reference to the role of combined h1 and h2 pharmacological blockade . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
154,
156
]
} |
the required time for loss of half of the radioactivity that had been bound to the cell membrane at time zero was 22.8 +/- 2.3 h for hcg , 23.3 +/- 1.1 h for asialo-hcg , 15.1 +/- 1.4 h for hlh , 0.4 +/- 0.2 h for olh , and 0.3 +/- 0.1 for megf . | organism_has_gene | {
"id": "C0086418",
"name": "hlh",
"pos": [
190,
193
]
} | {
"id": "C1334338",
"name": "2",
"pos": [
206,
207
]
} |
human high molecular weight urokinase , a plasminogen activator , when minimally reduced with 0.01 m 2-mercaptoethanol for 10 h at ph 8.0 and 25 degrees c and then carboxymethylated with sodium iodoacetate , gave two chains , a functionally active heavy chain with about 80 % of the original activity and a light chain . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
248,
259
]
} |
the steady state kinetic parameters of activation of human glu-plasminogen by the active heavy chain were also similar to low molecular weight urokinase , as were the amidase parameters of these enzymes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
53,
58
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
89,
100
]
} |
formycin b is metabolized by cutaneous leishmania amastigotes within cultured human macrophages to give formycin b 5'-monophosphate and formycin a 5'-mono- , di- , and triphosphates . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
78,
83
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
158,
160
]
} |
by analysis of a series of somatic cell hybrids derived by fusion of either mouse or chinese hamster cells with leukocytes from different chronic myelocytic leukemia ( cml ) patients or from normal donors , we have localized the human oncogene , c-sis , on the q11 to qter segment of chromosome 22 and demonstrated its translocation from chromosome 22 to chromosome 9 ( q34 ) in cml . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
229,
234
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
235,
243
]
} |
by analysis of a series of somatic cell hybrids derived by fusion of either mouse or chinese hamster cells with leukocytes from different chronic myelocytic leukemia ( cml ) patients or from normal donors , we have localized the human oncogene , c-sis , on the q11 to qter segment of chromosome 22 and demonstrated its translocation from chromosome 22 to chromosome 9 ( q34 ) in cml . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
229,
234
]
} | {
"id": "C0751995",
"name": "c-sis",
"pos": [
246,
251
]
} |
to examine the expression of the cellular homolog of the abelson murine leukemia virus transforming gene ( the v-abl sequence ) , a dna probe representing the v-abl sequence was prepared . | organism_has_gene | {
"id": "C0000742",
"name": "abelson murine leukemia",
"pos": [
57,
80
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
159,
164
]
} |
heteroduplex analysis of fbj-msv dna with these recombinant clones showed that both the c-fos ( mouse ) and the c-fos ( human ) sequences hybridized to the entire 1.7-kb v-fos region . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
120,
125
]
} | {
"id": "C0087140",
"name": "v-fos",
"pos": [
170,
175
]
} |
the discovery of a human myeloma protein comprising a kappa l-chain with an increased mol . wt of 30,000 ) ( bouvet et . al. , 1980 ) prompted investigations on the incidence of such heavier l-chains among other human myeloma proteins . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C1420192",
"name": "heavier",
"pos": [
183,
190
]
} |
the transforming gene of a human lung carcinoma-derived cell line , hs242 , has been cloned in biologically active form , and identified as c-bas/has ( otherwise known as c-ha-ras ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
27,
32
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
176,
179
]
} |
in the present study , sequences encoding the tyrosine phosphorylation acceptor sites of the abelson murine leukaemia virus oncogene , v-abl , and its human cellular homologue , c-abl , have been identified and their nucleic acid sequences determined . | organism_has_gene | {
"id": "C0000742",
"name": "abelson murine leukaemia virus",
"pos": [
93,
123
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
135,
140
]
} |
as an alternative , gentle treatment with acid at room temperature or at 0 degrees c was effective in separating the alpha and beta chains of human mhc class ii glycoprotein dimers and proved superior in terms of preservation of at least one labile epitope on the beta chain . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
142,
147
]
} | {
"id": "C0017349",
"name": "mhc class ii",
"pos": [
148,
160
]
} |
a cdna clone , phla-a , containing sequences specific for a human class i hla antigen heavy chain , was isolated from a bank of clones made from partially purified hla-abc heavy chain mrna from the human lymphoblastoid cell line bristol 8 ( hla-a1 , a2 , b8 , b16 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
60,
65
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
172,
183
]
} |
although the functional significance of this specific gene amplification in neuroblastoma cells remains unknown , an indication that it may relate to the malignant phenotype of these cells follows from the remainder of our data which show that the amplified be ( 2 ) -c-59 gene shares partial homology with both the second and third exons , but not the first exon , of the human c-myc oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
373,
378
]
} | {
"id": "C0086661",
"name": "myc",
"pos": [
381,
384
]
} |
we have cloned the human homolog of this putative mammary oncogene and compared its structure to that of the mouse gene by heteroduplex analysis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
58,
66
]
} |
the 15 ; 12 translocations found in most murine plasmacytomas and the analogous 8 ; 14 translocation in human burkitt 's lymphomas involve scissions of murine chromosome 15 ( human chromosome 8 ) near the 5 ' end of the c-myc gene and subsequent fusion near an immunoglobulin heavy-chain gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
104,
109
]
} | {
"id": "C1704837",
"name": "end",
"pos": [
209,
212
]
} |
cross reaction of monoclonal antibodies to human mhc class i and class ii products with bovine lymphocyte subpopulations . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
43,
48
]
} | {
"id": "C0017355",
"name": "mhc class i",
"pos": [
49,
60
]
} |
we report that membrane preparations of human myometrium possess binding sites for [ 3h ] ro 5-4864 , a specific ligand for the peripheral type of benzodiazepine receptors . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
40,
45
]
} | {
"id": "C1823521",
"name": "peripheral",
"pos": [
128,
138
]
} |
this suggests that tif is presumably different from human mif and may represent a novel lymphokine which preferentially affects t cell migration in vitro . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
52,
57
]
} | {
"id": "C3538735",
"name": "mif",
"pos": [
58,
61
]
} |
the associated heavy chains consist of a single electrophoretic component that reacts exclusively with antibodies against human foetal myosin and has a mobility and peptide pattern distinct from that of adult fast and slow heavy chains . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
122,
127
]
} | {
"id": "C1420192",
"name": "heavy",
"pos": [
223,
228
]
} |
we conclude from these results that the ontogenesis of human muscle myosin shares certain common features with that observed in other species , except for the persistence until birth of a foetal form of heavy chain ( hcemb . ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
55,
60
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
203,
214
]
} |
from heterologous binding experiments using human placenta light chains and heavy chain fragments from bovine brain clathrin , it is concluded that the domains of light and heavy chains that are involved in the interaction are conserved across tissue and species boundaries . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
173,
185
]
} |
a methanogenic coccus isolated from human feces requires h2 and ch3oh for growth and uses h2 to reduce ch3oh to ch4 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
36,
41
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
90,
92
]
} |
in the presence of phospholipid , activated human protein c cleaves several peptide bonds in fragment d ( heavy chain of factor va ) , whereas in fragment f1f2 ( light chain of factor va ) there appears to be only one peptide bond that is slowly cleaved . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C1420192",
"name": "heavy",
"pos": [
106,
111
]
} |
the same cross-reactivity was observed with ctp 34 b4 ( murine x human ) somatic hybrid cells , which express class i molecules constituted of human hla heavy chains and murine beta 2-m . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
65,
70
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
153,
165
]
} |
finally , because quantitative differences of reactivity with the anti-human beta 2-m m.ab were observed , depending on the hla class i genes used for transformation , these results individualize two families of hla class i heavy chains responsible for different conformational modifications of murine beta 2-m . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
71,
76
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
224,
236
]
} |
cultured rat glioma c-6 cells , with beta-adrenergic receptors , and human lung wi-38 cells , with prostaglandin receptors , were exposed to catecholamine ( isoproterenol ) and prostaglandin e1 , respectively , while their junctions were probed with microinjected fluorescent-labelled mono- , di- , and triglutamate . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
69,
74
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
293,
295
]
} |
thymidine kinase negative ( tk- ) friend cells were transformed with recombinant molecules carrying human globin genes and the thymidine kinase gene of herpes simplex virus type 1 dna . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
100,
105
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
106,
118
]
} |
and ( d ) no human beta-globin polypeptide can be detected in the intact induced cells , indicating that fibroblast globin genes , even when induced to make mrna in an erythroid environment , do not synthesize an rna that is translated efficiently . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
13,
18
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
116,
128
]
} |
however , the broad haemopoietic transformation spectrum of the murine v-abl protein and the association of the abl oncogene with human chronic myelogenous leukaemia suggest that some special structure-function relationship for the abl protein might hold for the growth regulation of blood forming cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
130,
135
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
232,
235
]
} |
the ia antigen-associated invariant chain ( in ) exists in humans as two major related forms , p33 and p35 . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
59,
65
]
} | {
"id": "C1704794",
"name": "p35",
"pos": [
103,
106
]
} |
southern filter analysis of somatic cell hybrid lines mapped the structural gene to the short arm of human chromosome 1 , and in situ hybridization to chromosomes of human leukocytes further localized the homologous area to the 1p36.1 -- -- p34.1 region , with the most likely location being the distal region of 1p34 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
101,
106
]
} | {
"id": "C1415345",
"name": "p34",
"pos": [
314,
317
]
} |
as a first step in an ongoing study on the correlation of oncogene expression and tumorigenicity in hybrids made by fusing d98ah2 ( d98 ) carcinoma cells with normal diploid human fibroblasts , we determined which oncogenes are expressed in the d98 cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
174,
179
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
214,
223
]
} |
a comparison of human oncogene rnas described by other workers with those observed in the d98 cells revealed no alterations in the sizes of the rnas . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
16,
21
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
22,
30
]
} |
we have subjected the viral mos oncogene ( v-mos ) , the activated human h-ras oncogene [ h-ras ( a ) ] and the normal human h-ras protooncogene [ h-ras ( n ) ] to the transcriptional regulation of glucocorticoid hormones by in vitro recombination with the promoter region of the mouse mammary tumor virus long terminal repeat ( mmtv ltr ) and transfection into nih 3t3 cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
67,
72
]
} | {
"id": "C1705572",
"name": "h-ras",
"pos": [
147,
152
]
} |
a plasmid has been constructed which contains the normal human n-ras proto-oncogene under the transcriptional control of the steroid-sensitive promoter of the mouse mammary tumor virus long terminal repeat . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
57,
62
]
} | {
"id": "C0027260",
"name": "n-ras",
"pos": [
63,
68
]
} |
the results of southern analyses demonstrate that a mouse homologue of the human met oncogene is amplified 4- to 8-fold in 7 of 10 lines of these transformed nih3t3 mouse fibroblasts . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
75,
80
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
85,
93
]
} |
regeneration of the gtp-bound from the gdp-bound form of human and yeast ras proteins by nucleotide exchange . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
57,
62
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
73,
76
]
} |
the regeneration of the gtp-bound from the gdp-bound form of purified human and yeast ras proteins occurs in vitro by a nucleotide-exchange reaction . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
70,
75
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
86,
89
]
} |
for both human and yeast ras proteins the dissociation of the protein-bound gdp is the rate-limiting step in the presence of mg ions . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
9,
14
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
25,
28
]
} |
the development of mouse and human embryos was assessed in human amniotic fluid to determine its suitability as a culture medium for human in vitro fertilization ( ivf ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
29,
34
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
164,
167
]
} |
a preliminary trial comparing amniotic fluid with t6 + maternal serum in human ivf showed no significant difference in fertilization rate and embryo development during 42 to 48 hours in vitro . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
73,
78
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
79,
82
]
} |
the 2-cell murine embryo bioassay as quality control for human in vitro fertilization ( ivf ) was used to evaluate the effects of protein supplements , medium aging , and surgical glove coatings . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
57,
62
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
88,
91
]
} |
to determine whether there is a prognostic value in the percentage normal sperm morphologic features in a human in vitro fertilization ( ivf ) program , the authors conducted a prospective study in women with bilateral tubal damage . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
106,
111
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
137,
140
]
} |
in addition , increasing awareness of the role of oncogenes in human carcinogenesis has led to studies involving transfection experiments with oncogenes and hepatitis b viral genes in normal human cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
63,
68
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
143,
152
]
} |
we cloned human lymphotoxin ( lt ) cdna from a cdna library prepared from phorbol myristate acetate ( pma ) and con a-stimulated human t cell hybridoma ( ac5-8 ) cells , the nucleotide sequence of the cdna insert in the plasmid , plt13 , was determined and compared with those of peripheral blood mononuclear cell derived lt cdna and the lt gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
10,
15
]
} | {
"id": "C1706393",
"name": "lt gene",
"pos": [
338,
345
]
} |
both in humans and rats , expression of the igf-ii gene results in the appearance of several mrna species . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
8,
14
]
} | {
"id": "C1334091",
"name": "igf-ii gene",
"pos": [
44,
55
]
} |
sequence comparisons demonstrate that this dna segment has homology to the promoter regions of the human dihydrofolate reductase gene and the mouse interleukin 3 gene , as well as to a monkey dna sequence that has homology to the sv40 origin and promotes expression of an unidentified gene product . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
99,
104
]
} | {
"id": "C1708434",
"name": "interleukin 3 gene",
"pos": [
148,
166
]
} |
thus , human smc can express il-1 beta and il-1 alpha genes , or very similar ones , and secrete biologically active product in response to a pathological stimulus . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
7,
12
]
} | {
"id": "C1708430",
"name": "il-1 alpha genes",
"pos": [
43,
59
]
} |
an important human example is leprosy , in which hla class ii-linked ir genes determine the immune response against mycobacterium leprae , the causative organism of the disease . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
13,
18
]
} | {
"id": "C0017349",
"name": "hla class ii",
"pos": [
49,
61
]
} |
a survey of nine primary human breast tumors , three breast tumor cell lines , and three normal individuals revealed no evidence for gross amplification or rearrangement of the int-2 locus . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
25,
30
]
} | {
"id": "C1708016",
"name": "int-2",
"pos": [
177,
182
]
} |
we transfected the human ej bladder carcinoma oncogene ( ha-rasej-1 ) into multipotential embryonal carcinoma cell line p19 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
46,
54
]
} |
oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
111,
116
]
} | {
"id": "C0034678",
"name": "ras oncogenes",
"pos": [
117,
130
]
} |
normal rat fibroblasts of the established cell line rat 4 were cotransformed with activated human ras oncogenes and with a cloned chicken thymidine kinase ( tk ) gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
92,
97
]
} | {
"id": "C0034678",
"name": "ras oncogenes",
"pos": [
98,
111
]
} |
human immunodeficiency virus type 1 ( hiv-1 , htlv-iii/lav ) , the retrovirus responsible for acquired immune deficiency syndrome ( aids ) , shows a high degree of genetic polymorphism , particularly in the env gene . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
67,
77
]
} | {
"id": "C0017343",
"name": "env gene",
"pos": [
207,
215
]
} |
to identify possible relationships between homeo-box genes of mice and humans , we have compared the chromosomal location of homeo-box genes in these species . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
71,
77
]
} | {
"id": "C0017347",
"name": "homeo-box genes",
"pos": [
125,
140
]
} |
we have undertaken to increase the proliferative capacity of cultured human skeletal myocytes by transfection with a plasmid construct that contains the immortalizing and transforming large t antigen gene of simian virus 40 ( sv40 ) under the control of a zinc-sensitive metallothionein promoter . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
70,
75
]
} | {
"id": "C0029016",
"name": "transforming",
"pos": [
171,
183
]
} |
alpha-thalassaemia caused by a poly ( a ) site mutation reveals that transcriptional termination is linked to 3 ' end processing in the human alpha 2 globin gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
136,
141
]
} | {
"id": "C2697530",
"name": "alpha 2",
"pos": [
142,
149
]
} |
to investigate the molecular basis for the diversity in muscarinic cholinergic function , we have isolated the genes encoding the human m1 and m2 muscarinic receptors ( machr ) as well as two previously undiscovered machr subtypes , designated hm3 and hm4 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
130,
135
]
} | {
"id": "C1707129",
"name": "hm3",
"pos": [
244,
247
]
} |
in dna-hybridization experiments , two of the beta genes behave as bona fide p-family members in that they hybridize strongly with human dp beta probes and hybridize weakly with probes specific for other class ii gene families . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
131,
136
]
} | {
"id": "C0017349",
"name": "class ii gene",
"pos": [
204,
217
]
} |
linkage analysis with the human oncogene homolog erba1 , which maps to this region , suggests that this cancer-related gene is not the primary cause of nf1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C0242987",
"name": "erba1",
"pos": [
49,
54
]
} |
linkage analysis with the human oncogene homolog erba1 , which maps to this region , suggests that this cancer-related gene is not the primary cause of nf1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C0029016",
"name": "cancer",
"pos": [
104,
110
]
} |
the n-ras gene was first identified in both humans and mice as a mutationally activated oncogene found in tumors . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
44,
50
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
88,
96
]
} |
we have mapped the human ros1 ( formerly mcf3 ) and mas1 oncogenes to the distal half of chromosome 6q , within a region frequently rearranged in malignant cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C0812281",
"name": "mcf3",
"pos": [
41,
45
]
} |
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