text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
human cellular fps/fes cdna rescued via retroviral shuttle vector encodes myeloid cell ncp92 and has transforming potential . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1708010",
"name": "fps",
"pos": [
15,
18
]
} |
we have generated a cdna copy of human c-fps/fes from a 13 kb genomic dna by means of a retroviral shuttle vector , and have begun characterization of its biological and biochemical properties . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
33,
38
]
} | {
"id": "C1708010",
"name": "fps",
"pos": [
41,
44
]
} |
neisseria gonorrhoeae produces two phenotypically distinct types of iga1 proteases , each of which cleaves a specific peptide bond in the hinge region of the human iga1 heavy chain . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
158,
163
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
169,
180
]
} |
human sperm immaturity was tested by nuclear chromatin decondensation ( ncd ) in 1 % sodium dodecylsulphate ( sds ) of spermatozoa used in 74 consecutive ivf treatments . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
154,
157
]
} |
the expression of ras oncogene product p21 in human malignant pleurisy and primary lung cancer was studied immunocyto-histochemically with monoclonal antibodies ( moabs ) rp-28 and rp-35 against ras p21 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
46,
51
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
195,
198
]
} |
we constructed fusion genes consisting of the mouse metallothionein i ( mt ) 5 ' region and the coding region of either the human h-ras gene ( c-rasp3 ) or a mutated allele ( c-rast24 ) ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
124,
129
]
} | {
"id": "C0079471",
"name": "h-ras gene",
"pos": [
130,
140
]
} |
its transcribed sequences were shown to be distributed over a 30-kb span within a molecularly cloned 45-kb segment of human dna which contained the transforming gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
118,
123
]
} | {
"id": "C0029016",
"name": "transforming gene",
"pos": [
148,
165
]
} |
thus , these antigenic determinants appear to be different from the classical hla class i antigens and could be the human counterpart of the murine qa system or of the second h-2k gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
116,
121
]
} | {
"id": "C1708995",
"name": "second",
"pos": [
168,
174
]
} |
two regions of very high homology were delineated by analyzing the sequence of this chicken er cdna and comparing it to the sequences of the human er , human glucocorticoid , and chicken progesterone receptors and the p75-erba fusion product of the avian erythroblastosis virus . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
141,
146
]
} | {
"id": "C0242987",
"name": "erba",
"pos": [
222,
226
]
} |
human dna from 11 individuals was analysed by southern blot for the immunoglobulin genes coding for the heavy chain variable region ( vh ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
104,
115
]
} |
we present evidence that the human igf-ii gene has at least two promoters , and their expression may be developmentally controlled in the liver . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
29,
34
]
} | {
"id": "C1334091",
"name": "igf-ii gene",
"pos": [
35,
46
]
} |
expression in e. coli of erg : a novel gene in humans related to the ets oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
47,
53
]
} | {
"id": "C0812380",
"name": "ets",
"pos": [
69,
72
]
} |
these data indicate that ( 1 ) human and gp peripheral lung tissues respond to h1 , but not h2 , stimulation with the generation of pgf2 alpha and pge ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
31,
36
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
92,
94
]
} |
mild detergent treatment ( 0.1 % sarkosyl-0.1 % beta-mercaptoethanol ) of dane particle-rich fraction from human serum resulted in the release of core particles together with hbe antigen activity when examined by the reversed passive haemagglutination method . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
107,
112
]
} | {
"id": "C1415484",
"name": "hbe",
"pos": [
175,
178
]
} |
molecular analysis of normal and abnormal human globin genes and their gene products has recently provided information on the precise genetic events that result in hemoglobinopathies . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
42,
47
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
48,
60
]
} |
in the human , the presence of fibrin in crescents , as well as the response to heparinization in some cases , support the role of coagulation in the genesis of extracapillary cell proliferation . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
7,
12
]
} | {
"id": "C1414672",
"name": "genesis",
"pos": [
150,
157
]
} |
in two of the independent hybrids that produced human heavy chains , human chromosome 14 was the only human chromosome present in the hybrid cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
54,
66
]
} |
an amphotropic retrovirus packaging cell line was constructed in which the gag , pol , and env genes of the helper virus are separated on two different plasmids and in which the packaging signals and 3 ' long terminal repeats are removed . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
15,
25
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
81,
84
]
} |
an amphotropic retrovirus packaging cell line was constructed in which the gag , pol , and env genes of the helper virus are separated on two different plasmids and in which the packaging signals and 3 ' long terminal repeats are removed . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
15,
25
]
} | {
"id": "C0017343",
"name": "env genes",
"pos": [
91,
100
]
} |
these antibodies were shown to block fertilization of human oocytes in in vitro fertilization ( ivf ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
54,
59
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
96,
99
]
} |
we have previously reported highly potent basophil/mast cell ( bmc ) and basophil/eosinophil ( eo ) colony-stimulating activities ( csa ) in conditioned medium derived from cultured human nasal polyp epithelial scrapings ( np-cm ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
182,
187
]
} | {
"id": "C1706141",
"name": "np",
"pos": [
223,
225
]
} |
pulsed field gel electrophoresis and southern blot analysis showed that the human oncogenes , hst1 and int2 , which code for proteins homologous to fibroblast growth factors , are less than 45 kb apart on the long arm of chromosome 11 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
76,
81
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
82,
91
]
} |
pulsed field gel electrophoresis and southern blot analysis showed that the human oncogenes , hst1 and int2 , which code for proteins homologous to fibroblast growth factors , are less than 45 kb apart on the long arm of chromosome 11 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
76,
81
]
} | {
"id": "C0812290",
"name": "int2",
"pos": [
103,
107
]
} |
hiv-1 recombinant retrovirus ( rrv ) , where the gag , pol and part of env genes have been exchanged for the reporter nlslacz gene , expresses the reporter gene only in presence of tat . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
18,
28
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
55,
58
]
} |
hiv-1 recombinant retrovirus ( rrv ) , where the gag , pol and part of env genes have been exchanged for the reporter nlslacz gene , expresses the reporter gene only in presence of tat . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
18,
28
]
} | {
"id": "C0017343",
"name": "env genes",
"pos": [
71,
80
]
} |
these results illustrate the proximity of the human vh , dh and jh segments involved in creation of the complete heavy chain genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
46,
51
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
113,
124
]
} |
human and bovine cervical mucus penetration tests ( n = 57 ) were performed preceding ivf to test their prognostic value as sperm function tests for ivf . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
149,
152
]
} |
the aim of the present study was to identify and characterize the sites of pcp action ( sigma and/or pcp receptors ) in human peripheral blood leukocytes ( pbl ) using [ 3h ] haloperidol or 1,3 di ( 2- ( [ 5-3h ] tolyl ) guanidine ( [ 3h ] dtg ) to specifically label sigma receptors and 3,4- [ 3h ] - ( n ) - [ 1- ( 2-thienyl ) -cyclohexyl ] -piperidine ( [ 3h ] tcp ) to specifically label pcp receptors . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
120,
125
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
350,
352
]
} |
our data suggest that adenosine-induced suppression of histamine 's positive chronotropic and inotropic effects on human myocardium results both from an a1-mediated attenuation of h2-stimulatory effects and from the uncovering of h1 negative chronotropic and inotropic effects . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
115,
120
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
180,
182
]
} |
this region of the genome has been implicated in chronic lymphocytic leukaemia and also encodes the int-2 human oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
106,
111
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
112,
120
]
} |
in a survey of primary human bladder carcinomas from 24 patients , using the nih/3t3 transfection nude mouse tumor assay , we have detected an activated c-h-ras-1 gene in four cases . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
23,
28
]
} | {
"id": "C1705572",
"name": "h-ras",
"pos": [
155,
160
]
} |
the human c-ets-1 proto-oncogene locus was shown to translocate from chromosome 11 to 9 or 4 in certain patients with acute monocytic leukemia . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0812201",
"name": "ets-1",
"pos": [
12,
17
]
} |
the protein encoded in a novel human oncogene isolated by transfection of kaposi 's sarcoma dna is a growth factor with significant homology to basic and acidic fgfs . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
31,
36
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
37,
45
]
} |
neurotransmitter modulation of the human class ii gene dr alpha on multiforme glioblastoma cell lines . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
35,
40
]
} | {
"id": "C0017349",
"name": "class ii gene",
"pos": [
41,
54
]
} |
antibody p7 was used to quantitate the amount of p-glycoprotein present in drug-resistant kb lines at various levels of resistance and to demonstrate the presence of p-glycoprotein in nih 3t3 cells transfected with a cloned mdr1 cdna or human genomic dna encoding mdr1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
237,
242
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
264,
268
]
} |
several recent discoveries indicate that the ras genes , frequently activated to a transforming potential in some human tumours , belong to a large family that can be divided into three main branches : the first branch represented by the ras , ral and rap genes ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
114,
119
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
238,
241
]
} |
several recent discoveries indicate that the ras genes , frequently activated to a transforming potential in some human tumours , belong to a large family that can be divided into three main branches : the first branch represented by the ras , ral and rap genes ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
114,
119
]
} | {
"id": "C0812284",
"name": "ral",
"pos": [
244,
247
]
} |
human retinal pigment epithelial cells differentially express mhc class ii ( hla , dp , dr and dq ) antigens in response to in vitro stimulation with lymphokine or purified ifn-gamma . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C0017349",
"name": "mhc class ii",
"pos": [
62,
74
]
} |
the human tgf-beta 3 gene is spread over seven exons as in the case of the tgf-beta 1 gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1336622",
"name": "tgf-beta 3",
"pos": [
10,
20
]
} |
the human tgf-beta 3 gene is spread over seven exons as in the case of the tgf-beta 1 gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1366557",
"name": "tgf-beta 1 gene",
"pos": [
75,
90
]
} |
using peptide antibodies which had been raised against sequences predicted to be specific for the human c-fyn gene product , the c-fyn protein was identified . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
98,
103
]
} | {
"id": "C0812303",
"name": "fyn",
"pos": [
131,
134
]
} |
in human iggl the two heavy chains are crosslinked in the central portion of the molecule by two disulfide bridges forming a double chain bis-cystinyl cyclic peptide in parallel alignment . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
3,
8
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
22,
34
]
} |
in the course of these studies it was determined that nt2/d1 ec cells also express several transcripts that hybridize with a cdna probe for the human pdgf a-chain . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
144,
149
]
} | {
"id": "C1335200",
"name": "pdgf",
"pos": [
150,
154
]
} |
the influence of maternal dietary zinc intake and recombinant human interleukin-1 alpha ( rhil-1 alpha ) administration on metallothionein gene expression and the distribution of 65zn were investigated . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
62,
67
]
} | {
"id": "C1708430",
"name": "interleukin-1 alpha",
"pos": [
68,
87
]
} |
in human erythroleukemia ( k562 ) cells , in which embryonic and fetal globin genes are transcribed , all of the sequences we examined from the beta-globin domain replicated early during s phase , while in hela cells , in which globin genes are transcriptionally silent , these sequences replicated late during s . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
3,
8
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
228,
240
]
} |
however , some regions of the genome showed some homology to retroviral gag and pol open reading frames . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
61,
71
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
80,
83
]
} |
when the mutant ras2val-19 , which carries the equivalent of the human h-rasval-12 oncogene , was grown under conditions in which ras1 expression is repressed , the camp signal was absent . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
65,
70
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
83,
91
]
} |
genomic sequences for the large subunit of human rna polymerase ii corresponding to a part of the fifth exon were inserted into an expression vector at the carboxy-terminal end of the beta-galactosidase gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
43,
48
]
} | {
"id": "C1705846",
"name": "at",
"pos": [
149,
151
]
} |
to evaluate the possible role of this protease in the transformed phenotype , we transfected cloned genes for mouse or human mep into mouse nih 3t3 cells with an expression vector for the dominant , selectable human multidrug resistance ( mdr1 ) gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
119,
124
]
} | {
"id": "C0376623",
"name": "multidrug",
"pos": [
216,
225
]
} |
using a human tgf beta 1 cdna probe , we have detected two distinct tgf beta rnas in cultured primary chick embryo chondrocytes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C1366557",
"name": "tgf beta 1",
"pos": [
14,
24
]
} |
the predicted protein includes a signal peptide of 20-23 amino acids as in human tgf beta 1 and 2 , and a precursor protein consisting of 412 amino acids , which can be cleaved at a lys-arg site to produce a 112 amino acid processed peptide containing nine cysteine residues in the same positions as in human tgf beta 1 and 2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
75,
80
]
} | {
"id": "C1366557",
"name": "tgf beta 1",
"pos": [
309,
319
]
} |
at the nucleotide level , the processed coding region of tgf beta 3 shows 72 % and 76 % identity with the processed coding regions of human tgf beta 1 and tgf beta 2 , respectively ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
134,
139
]
} | {
"id": "C1366557",
"name": "tgf beta 1",
"pos": [
140,
150
]
} |
in human dna , sequences homologous to this element were located at the 5 ' end of the c-myb gene , i.e . in the same position as in the chicken and mouse genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
3,
8
]
} | {
"id": "C1704837",
"name": "end",
"pos": [
76,
79
]
} |
a hindiii polymorphism identified by the human early growth response gene 2 ( egr2 ) on chromosome 10 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
41,
46
]
} | {
"id": "C1414315",
"name": "early growth response",
"pos": [
47,
68
]
} |
the treatment of human infertility has changed enormously since the introduction of ivf and gift . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
17,
22
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
84,
87
]
} |
however , the abnormality was not so marked in the murine as in the human trisomy , and the ( n-3 ) / ( n-6 ) ratio in epg was primarily elevated on account of decreased proportions of 20:4 ( n-6 ) and 22:4 ( n-6 ) , there being no significant increase in ( n-3 ) pufa . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
68,
73
]
} | {
"id": "C1825057",
"name": "epg",
"pos": [
119,
122
]
} |
using a human transforming growth factor beta 1 ( tgf beta ) cdna probe , we have detected an rna species migrating at about 1.7 kilobases in cultured primary chicken embryo chondrocytes that is distinct from chicken tgf beta 1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C1366557",
"name": "tgf beta",
"pos": [
217,
225
]
} |
1 ) the binding characteristics of [ 3h ] 5-ht ( 5-hydroxytryptamine , serotonin ) were investigated in membrane preparations of several regions from calf , pig and human brain in the presence of 100 nmol/l 8-oh-dpat ( 8-hydroxy-2 [ di-n-dipropylamino ] tetralin ) and 100 nmol/l mesulergine in order to mask 5-ht1a and 5-ht1c sites . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
165,
170
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
238,
240
]
} |
rearrangement and loss of genetic material in dna of human ductal breast carcinoma was analyzed by restriction enzyme digestion , agarose gel electrophoresis and southern blot hybridization using 32p labeled c-ha-ras-1 and multilocus , minisatellite 15.1.11.4 as a probe . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
53,
58
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
213,
216
]
} |
the cells of the reactivated colony produced human ha-ras 1 mrna and p21 , and their dna displayed transforming activity for nih/3t3 recipient cells that was due to the original human ha-ras 1 oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
45,
50
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
187,
190
]
} |
the cells of the reactivated colony produced human ha-ras 1 mrna and p21 , and their dna displayed transforming activity for nih/3t3 recipient cells that was due to the original human ha-ras 1 oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
45,
50
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
193,
201
]
} |
we conclude that the methylation status of the promoter region of the human ha-ras 1 modulates the expression and consequently the transforming activity of the oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
70,
75
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
79,
82
]
} |
we conclude that the methylation status of the promoter region of the human ha-ras 1 modulates the expression and consequently the transforming activity of the oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
70,
75
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
160,
168
]
} |
after incubating human serum with [ 125i ] ioxynil , 2diep against anti-whole human serum and rocket immunoelectrophoresis against anti-tbpa , albumin or tbg were carried out . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
17,
22
]
} | {
"id": "C3814864",
"name": "tbg",
"pos": [
154,
157
]
} |
mouse ifn inhibited the development of transformed foci in nih 3t3 cultures transfected with the viral ha-musv ( ras ) and mo-musv ( mos ) oncogenes , or with the human bladder carcinoma ras ej/t24 dna . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
163,
168
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
187,
190
]
} |
analysis of total feline dna by genomic blot hybridization , using the viral oncogene of abelson murine leukemia virus as a specific probe , has led to the identification of multiple v-abl homologous genetic sequences in the cat genome . | organism_has_gene | {
"id": "C0000742",
"name": "abelson murine leukemia virus",
"pos": [
89,
118
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
183,
188
]
} |
these studies demonstrate that in human umbilical arteries 11-hete , 15-hete and a presumed di-hete are the products of cyclooxygenase . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
34,
39
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
92,
94
]
} |
we have isolated cloned human c-abl probes to analyze the organization and expression of abl genes in patients with cml and in k562 cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
24,
29
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
89,
92
]
} |
the reduction in hpgrf-induced gh release remained significant when corrected for the reduced intracellular gh content in the hypothyroid cultures . | organism_has_gene | {
"id": "C0086418",
"name": "hpgrf",
"pos": [
17,
22
]
} | {
"id": "C1418759",
"name": "hpgrf",
"pos": [
17,
22
]
} |
the human cellular myc gene is one of about 20 cellular oncogenes which code for a variety of proteins including protein kinases and growth factors . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0026902",
"name": "myc gene",
"pos": [
19,
27
]
} |
southern blot hybridization analysis of dna from human-chinese hamster somatic cell hybrids showed that the human igf-ii gene is located on chromosome 11 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
49,
54
]
} | {
"id": "C1334091",
"name": "igf-ii gene",
"pos": [
114,
125
]
} |
using the same igf-ii variant probe , a cosmid was isolated which contains the human igf-ii gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
79,
84
]
} | {
"id": "C1334091",
"name": "igf-ii gene",
"pos": [
85,
96
]
} |
the transfectants were examined for the presence of human oncogenes in relation to tumorigenic potential and composition of surface-located fucosyl glycopeptides by gel filtration , concanavalin-a-binding and high-performance liquid chromatography . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
52,
57
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
58,
67
]
} |
the data suggest that functions provided by human ras-oncogenes contribute to the alteration of membrane glycopeptides on tumor cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C0034678",
"name": "ras-oncogenes",
"pos": [
50,
63
]
} |
binding of 12.7g3 , as detected by immunofluorescence using flow microfluorometry , was positive for two human cell lines , gm 3161 and hfb-1 , both expressing hla-dr2 , and negative for two other cell lines , gm 3104 ( dr1,1 ) and gm 3164 ( dr4,4 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
105,
110
]
} | {
"id": "C1333247",
"name": "dr1",
"pos": [
220,
223
]
} |
a segment of the coding sequence of the abelson murine leukemia virus transforming gene ( v-abl ) has been inserted into a plasmid vector that allows its efficient and regulated expression in escherichia coli . | organism_has_gene | {
"id": "C0000742",
"name": "abelson murine leukemia virus",
"pos": [
40,
69
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
90,
95
]
} |
purified human peripheral blood polymorphonuclear neutrophils ( pmn ) were incubated at 37 degrees c with the fluorescent membrane potential sensitive cyanine dye di-o-c ( 5 ) ( 3 ) and exposed to a number of stimulatory agents ( n-formylmethionylleucylphenylalanine ( fmlp ) , cytochalasin b ( cyto b ) + fmlp , phorbol myristate acetate ( pma ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
9,
14
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
163,
165
]
} |
the single protein encoded by abelson murine leukemia virus is a fusion of sequence from the retroviral gag genes with the v-abl sequence . | organism_has_gene | {
"id": "C0000742",
"name": "abelson murine leukemia virus",
"pos": [
30,
59
]
} | {
"id": "C0080279",
"name": "genes",
"pos": [
108,
113
]
} |
our results show that interferon severely inhibits , to a similar extent , the stable transformation of ltk- and nih 3t3 cells by the chicken thymidine kinase ( tk ) gene , ecogpt gene , simian virus 40 , v-ha-ras , and human c-ha-ras and c-ki-ras oncogenes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
220,
225
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
244,
247
]
} |
tissue-specific levels of human glucose-6-phosphate dehydrogenase correlate with methylation of specific sites at the 3 ' end of the gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C1705846",
"name": "at",
"pos": [
111,
113
]
} |
since the human hras-2 also resides on the x chromosome , it appears that the cellular hras-2 gene ( or pseudogene ) conserved its chromosomal localization during mammalian evolution . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
10,
15
]
} | {
"id": "C0079471",
"name": "hras",
"pos": [
87,
91
]
} |
conjugated bilirubins in the biles of other animals ( human , monkey , pony , cat , rat and dog ) are chemically more diverse and include mono- , di- and mixed disconjugates of glucuronic acid , xylose and glucose in proportions that give distinct patterns for each species . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
54,
59
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
239,
241
]
} |
tyrosine-specific protein kinase ( atp : protein phosphotransferase , ec 2.7.1.37 ) activity was measured in normal human nonadherent peripheral blood lymphocytes using synthetic peptide substrates having sequence homologies with either pp60src or c-myc . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
116,
121
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
248,
253
]
} |
we have examined a panel of human lung cancer cell lines for amplification and expression of the c-myc , n-myc , and c-myb oncogenes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
28,
33
]
} | {
"id": "C0812287",
"name": "n-myc",
"pos": [
105,
110
]
} |
human ferritins purified from normal liver ( lf ) and from hepatocellular carcinoma ( hf ) showed different biochemical and immunological characteristics . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1416933",
"name": "lf",
"pos": [
45,
47
]
} |
a target structure for a series of human cloned natural killer cell lines is recognized by both anti-tnktar and 4f2 monoclonal antibodies . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
35,
40
]
} | {
"id": "C1420192",
"name": "4f2",
"pos": [
112,
115
]
} |
nih/3t3 cells transfected with human tumor dna containing activated ras oncogenes express the metastatic phenotype in nude mice . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
31,
36
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
68,
71
]
} |
thus , transfection with human tumor dna containing activated ras oncogenes can induce the complete metastatic phenotype in nih/3t3 cells by a mechanism apparently unrelated to immune cell killing . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
25,
30
]
} | {
"id": "C0034678",
"name": "ras oncogenes",
"pos": [
62,
75
]
} |
we have cotransfected nmumg cells with psv2neo and genomic dna from the human ej bladder carcinoma line , a cell line which contains an activated c-rash oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
72,
77
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
153,
161
]
} |
genomic dna transfection into a line of mouse epithelial cells , in combination with the selection of stable transfectants and tumor induction in nude mice , can be used to screen human tumor dna for the presence of activated oncogenes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
180,
185
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
226,
235
]
} |
our results indicate that the activated human ras oncogene may confer metastatic potential onto lymphoid tumor cells , probably due to the induction of invasiveness . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
40,
45
]
} | {
"id": "C0034678",
"name": "ras oncogene",
"pos": [
46,
58
]
} |
the human heavy chain enhancer element was ligated tot he chimeric heavy and light chain genes , and this enhancer appeared to be obligatory for the efficient production of the chimeric antibody molecules . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
10,
21
]
} |
monophasic action potential mapping in human subjects with normal electrocardiograms : direct evidence for the genesis of the t wave . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
39,
44
]
} | {
"id": "C1414672",
"name": "genesis",
"pos": [
111,
118
]
} |
we have examined the expression of the transformed phenotype in a series of clonal lines of nih/3t3 cells transfected with the human c-ha-rasval 12 oncogene and the neomycin phosphotransferase gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
127,
132
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
148,
156
]
} |
one of these ligands , 125i-labeled pta-oh , a txa2/pgh2 receptor antagonist , has been extensively used to characterize the human platelet txa2/pgh2-binding site . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
125,
130
]
} | {
"id": "C0919509",
"name": "pgh2",
"pos": [
145,
149
]
} |
hemoglobin m iwate is caused by a c -- -- t transition in codon 87 of the human alpha 1-globin gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
74,
79
]
} | {
"id": "C2697529",
"name": "alpha 1-globin gene",
"pos": [
80,
99
]
} |
the serologic reactivity could be blocked by turkey sera to human b2-microglobulin but not by turkey anti-ia-like . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
60,
65
]
} | {
"id": "C1415587",
"name": "b2-microglobulin",
"pos": [
66,
82
]
} |
southern hybridization analyses with different portions of a full-length cdna indicate that the human mdr1 gene encompasses at least 70 kilobases of dna amplified in all highly multidrug-resistant cell lines . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
96,
101
]
} | {
"id": "C0376623",
"name": "mdr1 gene",
"pos": [
102,
111
]
} |
human placental villous trophoblast is known to be unreactive with w6/32 and other monoclonal antibodies recognizing monomorphic determinants of human class i mhc heavy chains , whereas extravillous cytotrophoblast in the placental bed is w6/32-reactive by immunohistology . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C0017355",
"name": "class",
"pos": [
151,
156
]
} |
human placental villous trophoblast is known to be unreactive with w6/32 and other monoclonal antibodies recognizing monomorphic determinants of human class i mhc heavy chains , whereas extravillous cytotrophoblast in the placental bed is w6/32-reactive by immunohistology . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
163,
175
]
} |
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