text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
introduction of a human beta 2-microglobulin gene into l cells transfected with the hla-b27 gene rescued the expression of hla-b27 at the cell surface , as evidenced by reactivity with w6/32 , surface staining , and the presence of sialic acid on the heavy chain . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
251,
262
]
} |
in this study , we demonstrate that the murine polymorphic class ii antigens of an interspecies mouse-human hybrid , which has segregated the murine invariant chain gene , associates with the human invariant chain gene intracytoplasmically . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
102,
107
]
} | {
"id": "C3273406",
"name": "invariant chain gene",
"pos": [
198,
218
]
} |
in this study , we present evidence that functionally mature , normal human t cells have rearranged their t gamma genes but display a limited range of gene rearrangement choices . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
70,
75
]
} | {
"id": "C1420562",
"name": "t",
"pos": [
168,
169
]
} |
the protein product of this oncogene , p48v-myb , is partially encoded by the retroviral gag and env genes . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
78,
88
]
} | {
"id": "C0017343",
"name": "env genes",
"pos": [
97,
106
]
} |
to assess the relationship of hydralazine to human breast cancer , 3,419 women with breast cancer and 3,219 hospital control subjects were studied . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
45,
50
]
} | {
"id": "C1332438",
"name": "3",
"pos": [
102,
103
]
} |
comparison of the rat and human c-ha-ras -1 exons showed an area of poor homology immediately upstream of the human cap sites , followed further upstream by a region of close homology ( approximately equal to 60 base pairs ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
37,
40
]
} |
cultured human embryonal rhabdomyosarcoma cells express the basic fibroblast growth factor ( bfgf ) gene and they produce bfgf , which is apparently composed of two microheterogenous forms with mrs of 16,500 and 17,200 , respectively . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
9,
14
]
} | {
"id": "C1708015",
"name": "basic fibroblast",
"pos": [
60,
76
]
} |
on the basis of this experiment grade 2 water was used in the tygerberg hospital human ivf programme with good results . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
81,
86
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
87,
90
]
} |
mitogenic stimulation of quiescent human fibroblasts ( hswp ) with a growth factor mixture ( consisting of epidermal growth factor ( egf ) , insulin , bradykinin , and vasopressin ) rapidly induces an increase in na influx via a ca-mediated activation of an amiloride-sensitive na/h exchanger . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
35,
40
]
} | {
"id": "C1420229",
"name": "ca",
"pos": [
229,
231
]
} |
purification and characterization of human colony-stimulating factor 1 from human pancreatic carcinoma ( mia paca-2 ) cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
37,
42
]
} | {
"id": "C1417154",
"name": "mia",
"pos": [
105,
108
]
} |
colony-stimulating factor 1 ( csf-1 ) was purified from the serum-free conditioned medium of a human pancreatic carcinoma cell line ( mia paca-2 ) by a combination of conventional chromatography and high-performance liquid chromatography . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
95,
100
]
} | {
"id": "C1417154",
"name": "mia",
"pos": [
134,
137
]
} |
using these radioimmunoassays and ras p21 purified from escherichia coli containing the full-length t24 mutant human harvey ras gene protein product as a standard , we have defined the actual amount of ras p21 per micrograms of total cellular protein , or per cell , in various ras transformed and 'normal ' mammalian cell lines . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
111,
116
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
278,
281
]
} |
a panel of alloindifferent monoclonal antibodies ( mab 's ) was used in complement-dependent lysis to characterize human myeloid , erythroid and multipotential progenitors ( cfu-gm , bfu-e , cfu-gemm ) for their expression of mhc class ii hla-dr , -dp , and -dq products . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
115,
120
]
} | {
"id": "C0017349",
"name": "mhc",
"pos": [
226,
229
]
} |
to study the class ii genes of the major histocompatibility region of the sheep genome , human hla class ii genes corresponding to the known subregions in man ( dr , dq , dp , do , and dz ) were used for southern hybridization analysis of sheep dna and to probe a sheep genomic library . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
89,
94
]
} | {
"id": "C0017349",
"name": "hla class ii genes",
"pos": [
95,
113
]
} |
using the human c-erbb-2 cdna as a probe , we applied in situ hybridization techniques to acute promyelocytic leukemia cells with a 15 ; 17 chromosome translocation , t ( 15 ; 17 ) ( q ; 22 ; q21 ) , and were able to localize the c-erbb-2 gene on chromosome 17 to band q12 or q21 and on the proximal side of the breakpoint in the translocation . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
10,
15
]
} | {
"id": "C0243036",
"name": "erbb",
"pos": [
232,
236
]
} |
the results show that both human ril-1 alpha and ril-1 beta induce the differentiation of 70z/3 , but a higher concentration of ril-1 beta compared to ril-1 alpha is needed for a maximal response . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
27,
32
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
151,
154
]
} |
these results show that human fetal astrocytes can be induced to express hla-dr by ifn-gamma in vitro and support the concept that astrocytes may function as antigen-presenting cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
24,
29
]
} | {
"id": "C1413237",
"name": "hla-dr",
"pos": [
73,
79
]
} |
various concentrations of recombinant human il 1 beta ( ril 1 ) and media conditioned by monocytes ( mcm ) , endothelial cells ( ecm ) , and endothelial cells cultured for 3 days in 50 % mcm ( ecmm ) or ril 1 ( ecmril 1 ) were added to marrow mononuclear cells cultured in methylcellulose . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
38,
43
]
} | {
"id": "C1709402",
"name": "mcm",
"pos": [
187,
190
]
} |
various concentrations of recombinant human il 1 beta ( ril 1 ) and media conditioned by monocytes ( mcm ) , endothelial cells ( ecm ) , and endothelial cells cultured for 3 days in 50 % mcm ( ecmm ) or ril 1 ( ecmril 1 ) were added to marrow mononuclear cells cultured in methylcellulose . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
38,
43
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
214,
217
]
} |
preincubation with specific antisera to native human il 1 or ril 1 reduced by 75 to 100 % the activity of mcm in stimulating endothelial cell release of bpa , gm-csa , meg-csa , and mixed-cell csa . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
47,
52
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
61,
64
]
} |
preincubation with specific antisera to native human il 1 or ril 1 reduced by 75 to 100 % the activity of mcm in stimulating endothelial cell release of bpa , gm-csa , meg-csa , and mixed-cell csa . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
47,
52
]
} | {
"id": "C1709402",
"name": "mcm",
"pos": [
106,
109
]
} |
these ab neutralized human recombinant il 1 alpha ( ril 1 alpha ) activity effectively , but did not interfere with human ril 1 beta , murine ril 1 alpha , or human ril 2 activity . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
21,
26
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
165,
168
]
} |
the nucleotide sequence of the abl segment in the hz2-fesv genome was determined and compared with the murine and human v-abl and c-abl sequences . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
114,
119
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
120,
125
]
} |
the 5 ' 189 base pairs of fv-abl correspond to 5 ' c-abl sequences not contained in abelson murine leukemia virus ( mulv ) v-abl . | organism_has_gene | {
"id": "C0000742",
"name": "abelson murine leukemia virus",
"pos": [
84,
113
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
123,
128
]
} |
comparison of the predicted amino acid sequence of fv-abl with those of abelson mulv v-abl and c-abl revealed five aa differences . | organism_has_gene | {
"id": "C0000742",
"name": "abelson mulv",
"pos": [
72,
84
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
85,
90
]
} |
a monoclonal antibody ( moab , sk-930 ) of the igg2a subclass to human pancreatic carcinoma cells ( mia-paca 2 ) was obtained by hybridization of spleen cells from immunized balb/c mice with murine myeloma cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
65,
70
]
} | {
"id": "C1417154",
"name": "mia",
"pos": [
100,
103
]
} |
the complete coding sequence of the human a-raf-1 oncogene and transforming activity of a human a-raf carrying retrovirus . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
36,
41
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
50,
58
]
} |
functionally , human a-raf is similar to v-raf and v-mos in that transformation is independent of ras gene function . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
15,
20
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
98,
101
]
} |
an insert of 149 bp present at the 5 ' end of exon 7 of human c-sis but absent in the simian sarcoma virus v-sis oncogene was also present in the feline c-sis proto-oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
56,
61
]
} | {
"id": "C0037207",
"name": "v-sis",
"pos": [
107,
112
]
} |
the coordinated appearance of these groups of polypeptides and their similar size and reactivity with human sera and rabbit antisera produced against the isolated p52 as well as with a monoclonal antibody ( r3 ) suggested that most of these polypeptides are derived from post-translational modifications of one or a few initially synthesized polypeptides , possibly p52 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
102,
107
]
} | {
"id": "C1415346",
"name": "p52",
"pos": [
366,
369
]
} |
a scheme is proposed for generating the intact val-448-phe-545 polypeptide of human plasminogen which contains the fifth kringle domain of the plasmin heavy chain . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
78,
83
]
} | {
"id": "C1420192",
"name": "heavy",
"pos": [
151,
156
]
} |
[ 3h ] pk 11195 bound in a similar fashion to slide-mounted sections of human brain , thus allowing quantitative studies of the regional distribution of peripheral-type benzodiazepine binding sites to be made . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
72,
77
]
} | {
"id": "C1823521",
"name": "peripheral",
"pos": [
153,
163
]
} |
the results provide additional evidence that h2 receptors are present in the human cutaneous microcirculation , and add support to the clinical observation of therapeutic efficacy of h1 plus h2 blockers seen in some patients with chronic urticaria . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
77,
82
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
191,
193
]
} |
investigations on the regulation of human globin gene expression are assisted by a knowledge of the chromosomal location of the globin genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
36,
41
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
128,
140
]
} |
selected compounds were compared with 1a in an avoidance-response acquisition model which differentiates between 1a and the human hallucinogens dom ( 2a ) and doet ( 2b ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
124,
129
]
} | {
"id": "C3539821",
"name": "dom",
"pos": [
144,
147
]
} |
at-125 , ( alpha s , 5s ) -alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid , at a concentration of 5 microm was found to inhibit the growth of human pancreatic carcinoma cells ( mia paca-2 ) by 78 % after 72 hours in continuous culture . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
151,
156
]
} | {
"id": "C1417154",
"name": "mia",
"pos": [
186,
189
]
} |
ossification of some normal ligaments of the human skull which produce new structures : the pterygospinous and pterygoalar bars and foramina , and the caroticoclinoid foramen . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
45,
50
]
} | {
"id": "C1707156",
"name": "bars",
"pos": [
123,
127
]
} |
hemoglobin synthesis in somatic cell hybrids : coexpression of mouse with human or chinese hamster globin genes in interspecific somatic cell hybrids of mouse erythroleukemia cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
74,
79
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
99,
111
]
} |
rna extracted from the human marrow x erythroleukemia hybrid annealed equally to both human and mouse globin complementary dna , indicating that coexpression of the globin genes of each species had occurred in the hybrid cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
23,
28
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
165,
177
]
} |
papain solubilization of rat ag-b histocompatibility antigens produces ag-b molecules of about 59,000 daltons which have been shown to contain two fragments bound noncovalently : one fragment about 37,000 daltons carrying ag-b allospecificity , and another about 11,000 daltons , an apparent rat homologue of human beta2-microglobulin . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
309,
314
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
315,
320
]
} |
the electrophoretic pattern of human fibroblast extracts displays three bands ( cathode to anode ) of hexosaminidase : hex b , hex a , hex c in normal strains , only one b band in tay-sachs strains , and only one c band in sandhoff strains . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
31,
36
]
} | {
"id": "C1415537",
"name": "hex",
"pos": [
135,
138
]
} |
the analysis of man-rodent hybrids ( hamster and mouse with normal and sandhoff human fibroblasts ) indicates a probable synteny between mpi , hex c , `` '' hex a fast '' '' , and `` '' hex a-like '' '' . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
80,
85
]
} | {
"id": "C1415537",
"name": "hex",
"pos": [
186,
189
]
} |
the b-cell mitogens which were used were dextran sulphate , lipopolysaccharide , purified protein derivative , as well as rabbit anti-human beta2-microglobulin serum . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
134,
139
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
140,
145
]
} |
fifty-nine human dna samples derived from either normal tissues or hematopoietic neoplasias were examined for rearrangements in the mlvi-2 locus , a putative oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
11,
16
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
158,
166
]
} |
this fragment , jy150/c5 , hybridized with two genomic bands in dna from human hla homozygotes -- presumably the hla-b locus gene and a closely related gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
73,
78
]
} | {
"id": "C1415561",
"name": "hla-b locus gene",
"pos": [
113,
129
]
} |
treatment of nih 3t3 cells with interferon ( ifn ) after transfection with human bladder carcinoma ej/t24 c-ha-ras1 oncogene dna caused inhibition of ras-induced cell transformation . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
75,
80
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
116,
124
]
} |
treatment of nih 3t3 cells with interferon ( ifn ) after transfection with human bladder carcinoma ej/t24 c-ha-ras1 oncogene dna caused inhibition of ras-induced cell transformation . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
75,
80
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
150,
153
]
} |
neither human nor sheep cells showed any enhanced [ 32p ] phosphate labelling of phosphoproteins when treated with 1-mono-oleoyl-rac-glycerol . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C1419227",
"name": "1",
"pos": [
115,
116
]
} |
isolation and partial characterization of genomic clones coding for a human pro-alpha 1 ( ii ) collagen chain and demonstration of restriction fragment length polymorphism at the 3 ' end of the gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
70,
75
]
} | {
"id": "C1705846",
"name": "at",
"pos": [
172,
174
]
} |
serum depleted of the first component of complement ( c1d ) was prepared by treating fresh human serum with sepharose-igg in the presence of triethylenetetramine-n , n , n ' , n '' , n '' ' , n '' '-hexa-acetic acid and di-isopropyl fluorophosphate at acidic ph ( 5.2 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
91,
96
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
255,
257
]
} |
the molecular weight difference in apoe observed among new and old world monkeys , as well as the molecular weight and/or charge differences observed among monkey , ape , and human apoe are consistent with structural changes in the apoe gene which have occurred following the divergence of the different species . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
175,
180
]
} | {
"id": "C1412481",
"name": "apoe gene",
"pos": [
232,
241
]
} |
like the corresponding human zeta 1 and zeta 2 genes , the first and second introns of the chimpanzee zeta 1 gene are occupied largely by tandem repeats of short oligonucleotides . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
23,
28
]
} | {
"id": "C1708995",
"name": "second",
"pos": [
69,
75
]
} |
our data suggest that the antigen associated with a human acute lymphocytic leukemia oncogene is ubiquitous , distributed among both neoplastic and normal hemopoietic cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
52,
57
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
85,
93
]
} |
human plasma retinol-binding protein has been purified to homogeneity by a simple method that requires an ammonium sulfate fractionation , a hydrophobic interaction chromatography on phenyl-sepharose , which dissociates the complex between retinol-binding protein and its carrier , transthyretin , and a gel filtration on sephadex g-50 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1419320",
"name": "plasma retinol-binding protein",
"pos": [
6,
36
]
} |
the sequence of the 3 ' part of this cdna reveals a domainal organization of the derived protein similar to that of the known p-glycoproteins and an 80 % amino acid homology with the product of the human mdr1 gene ( chen et al. , 1986 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
198,
203
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
204,
208
]
} |
human ( hela ) cells contain a protein , mltf , which specifically binds to a dna sequence in the adenovirus 2 major late promoter and activates transcription of that promoter . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1421376",
"name": "mltf",
"pos": [
41,
45
]
} |
combined protein and dna sequencing studies reveal that human rfs utilize a small number of light chain variable region genes , together with several heavy chain variable regions genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
56,
61
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
150,
161
]
} |
three different methods were used for freezing human excess oocytes ( 320 frozen , 205 thawed ) in our ivf programme and the results of these methods were compared . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
47,
52
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
103,
106
]
} |
however , the high degree of conservation of the phosphorylation sites for protein kinase c between human and mouse abl proteins suggests an important functional role . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
100,
105
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
116,
119
]
} |
we have examined the secretion of il-3 like activity from recipient normal mouse , rat and chinese or syrian hamster cells and their derivative cell lines obtained after transfection with recombinant plasmids carrying an exogenous human ras or myc gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
231,
236
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
237,
240
]
} |
we have examined the secretion of il-3 like activity from recipient normal mouse , rat and chinese or syrian hamster cells and their derivative cell lines obtained after transfection with recombinant plasmids carrying an exogenous human ras or myc gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
231,
236
]
} | {
"id": "C0026902",
"name": "myc gene",
"pos": [
244,
252
]
} |
radioiodination of synthetic human 37-49 osteocalcin requires optimal labeling conditions in order to obtain a maximum of mono- and di-iodinated tracer with little contamination by tri- and tetra-iodinated products or `` '' radio-damage . '' '' | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
29,
34
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
226,
228
]
} |
recombinant human interleukin-l ( ril-1 ) alpha and beta , which have 26 % homology in their amino acid sequence , stimulated arachidonic acid metabolism by squirrel monkey smooth muscle cells and rat liver cells ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
12,
17
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
34,
37
]
} |
whereas human spermatozoa contain predominantly di- , tri- and tetraenoic fatty acids with up to 32 carbon atoms , boar , ram and bull spermatozoa also contain pentaenoic and/or hexaenoic acids with up to 34 carbon atoms . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
48,
50
]
} |
the regularity of the association between the translocation events and the tumors where they occur , together with the similarities between the human , mouse and rat systems can be interpreted by postulating that the activation of c-myc by the translocation represents an essential step in the genesis of these tumors . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
144,
149
]
} | {
"id": "C1414672",
"name": "genesis",
"pos": [
294,
301
]
} |
thus , the introduction of a single copy of a human chromosome 11 is sufficient to completely suppress the tumorigenic phenotype of hela cells and is suggestive of the presence of tumor-suppressor gene ( s ) on this chromosome . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
46,
51
]
} | {
"id": "C0079427",
"name": "tumor-suppressor gene",
"pos": [
180,
201
]
} |
the ia antigen-associated invariant chain ( in ) exists in humans as four related polypeptides , p33 , p35 , p41 and p43 , all associated with hla-class ii antigens . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
59,
65
]
} | {
"id": "C1704794",
"name": "p35",
"pos": [
103,
106
]
} |
chemical modification of a plasmid containing the human c-ha-ras proto-oncogene ( psvmbras-gpt ) in vitro with the ultimate carcinogens n-acetoxy-2-amino-6-methyldipyrido [ 1,2-a : 3',2'-d ] imidazole ( n-oac-glu-p-1 ) and n-acetoxy-4-aminoquinoline n-oxide ( n-oac-4aqo ) generated an activated oncogene that transformed nih3t3 cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
50,
55
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
296,
304
]
} |
expression in escherichia coli of synthetic human interleukin-1 alpha genes encoding the processed active protein , mutant proteins , and beta-galactosidase fusion proteins . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C1708430",
"name": "interleukin-1 alpha genes",
"pos": [
50,
75
]
} |
to analyze human tumors for the presence of mutated ras oncogenes , a procedure was developed based on selective hybridization of mutation-specific oligodeoxynucleotide probes to genomic dna [ bos et al. , nucl . acids res . 12 ( 1984 ) 9155-9163 ] . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
11,
16
]
} | {
"id": "C0034678",
"name": "ras oncogenes",
"pos": [
52,
65
]
} |
rh 123 is recommended as an alternative means of assessing human spermatozoal viability , and the results arising from the use of this technique here are discussed with their particular relevance to semen freezing and preparation in ivf centers . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
59,
64
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
233,
236
]
} |
normally , human adults express five types of immunoglobulin -- igm , igd , igg , ige and iga ( defined by the class of heavy chain constant region ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
11,
16
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
120,
131
]
} |
the transforming gene found in a human bladder carcinoma cell line , t24 , is h-ras-1 , the human homologue of the harvey sarcoma virus oncogene ( v-h-ras ) 6-9 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
33,
38
]
} | {
"id": "C0079471",
"name": "harvey sarcoma virus oncogene",
"pos": [
115,
144
]
} |
the transforming gene found in a human bladder carcinoma cell line , t24 , is h-ras-1 , the human homologue of the harvey sarcoma virus oncogene ( v-h-ras ) 6-9 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
33,
38
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
151,
154
]
} |
this bladder carcinoma oncogene has been shown to be of human origin , less than six kilobase pairs ( kbp ) in size , and closely related to the onc genes ( v-bas and v-ras ) of balb and harvey murine sarcoma viruses . | organism_has_gene | {
"id": "C0086418",
"name": "human origin",
"pos": [
56,
68
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
169,
172
]
} |
with reference , namely to bateson , bourdieu , lewin , pankow , he defines operational concepts which put into connection human communication , sociological context and genesis of personality . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
123,
128
]
} | {
"id": "C1414672",
"name": "genesis",
"pos": [
170,
177
]
} |
the cross-reacting antigen possessing tissue specificity was found in human tumor cells histogenetically associated with the tissues carrying the antigen ( basal cell carcinoma , squamous cell carcinoma of the skin , larynx , cervix ) but not in the cells of tumors of different genesis ( infiltrative mammary gland carcinoma , adenocarcinomas of the stomach and intestines ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
70,
75
]
} | {
"id": "C1414672",
"name": "genesis",
"pos": [
279,
286
]
} |
an antibody ( w6/32 ) which only reacts with the hla/beta 2-microglobulin complex in humans and not with the free hla heavy chain has the reverse specificity in some owl monkeys . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
85,
91
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
118,
129
]
} |
somatostatin-immunoreactive cells ( gif-cells ) in the human and canine intestine had no direct cellular contacts with gli-immunoreactive cells ( gli-cells ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
55,
60
]
} | {
"id": "C0812304",
"name": "gli",
"pos": [
146,
149
]
} |
in contrast a limited number of gif-cells was found in the human duodenum where a few gli-cells were distributed and a few gif-cells were seen in the human ileum where a large number of gli-cells were located . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
59,
64
]
} | {
"id": "C0812304",
"name": "gli",
"pos": [
186,
189
]
} |
restriction enzyme digestion analysis and direct human globin gene cloning have permitted analysis of the physical arrangement of nucleotide sequences within and surrounding the human globin genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
49,
54
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
184,
196
]
} |
the resting transmembrane potential ( em ) of human granulocytes was estimated using the fluorescent lipophilic cation , di-s-c3 ( 5 ) , from the null point for potassium -- i.e. , the external k concentration at which there is no change in em in response to valinomycin ( a k ionophore ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
46,
51
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
121,
123
]
} |
rias developed with these antisera are effective for each hnp in the range of 5-320 pg . | organism_has_gene | {
"id": "C0086418",
"name": "hnp",
"pos": [
58,
61
]
} | {
"id": "C1706141",
"name": "hnp",
"pos": [
58,
61
]
} |
in healthy , sitting , normally hydrated subjects of both sexes , vp-hnp and ot-hnp were , respectively , 73 +/- 5 and 382 +/- 30 pg/ml ( mean +/- sem ; n = 20 ) ; | organism_has_gene | {
"id": "C0086418",
"name": "hnp",
"pos": [
69,
72
]
} | {
"id": "C1706141",
"name": "hnp",
"pos": [
80,
83
]
} |
women on oral contraceptives had elevated ( > 3 times normal ) levels of ot-hnp but normal levels of vp-hnp . | organism_has_gene | {
"id": "C0086418",
"name": "hnp",
"pos": [
76,
79
]
} | {
"id": "C1706141",
"name": "hnp",
"pos": [
104,
107
]
} |
eleven patients who had the syndrome of inappropriate secretion of antidiuretic hormone had elevated levels of vp-hnp but not necessarily of ot-hnp . | organism_has_gene | {
"id": "C0086418",
"name": "hnp",
"pos": [
114,
117
]
} | {
"id": "C1706141",
"name": "hnp",
"pos": [
144,
147
]
} |
in two of six subjects smoking caused a dramatic release of vp-hnp , as indexed by plasma levels which rose to more than 50 times the control values . | organism_has_gene | {
"id": "C0086418",
"name": "hnp",
"pos": [
63,
66
]
} | {
"id": "C1706141",
"name": "hnp",
"pos": [
63,
66
]
} |
double-stranded dna copies of the rna gene coding for the haemagglutinin glycoproteins from human h2 and h3 pandemic strains of influenza virus have been cloned . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
92,
97
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
98,
100
]
} |
site-specific mutagenesis of the human interleukin-1 beta gene : the role of arginine residue at the n-terminal region . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
33,
38
]
} | {
"id": "C1708431",
"name": "interleukin-1 beta gene",
"pos": [
39,
62
]
} |
regulation of human estrogen receptor gene , epidermal growth factor receptor gene , and oncogenes by estrogen and antiestrogen in mcf-7 breast cancer cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
14,
19
]
} | {
"id": "C1414461",
"name": "estrogen receptor gene",
"pos": [
20,
42
]
} |
regulation of human estrogen receptor gene , epidermal growth factor receptor gene , and oncogenes by estrogen and antiestrogen in mcf-7 breast cancer cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
14,
19
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
89,
98
]
} |
experiments using mcf-7 human breast cancer cells were carried out to study the regulatory effect of estrogen and antiestrogen on rna activities of oncogenes , estrogen receptor gene , and epidermal growth factor ( egf ) receptor gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
24,
29
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
148,
157
]
} |
experiments using mcf-7 human breast cancer cells were carried out to study the regulatory effect of estrogen and antiestrogen on rna activities of oncogenes , estrogen receptor gene , and epidermal growth factor ( egf ) receptor gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
24,
29
]
} | {
"id": "C1414461",
"name": "estrogen receptor gene",
"pos": [
160,
182
]
} |
the transcript is derived from a single gene called nvhbox 1 , the newt homologue of xihbox 1 ( xenopus ) , hho.c8 ( human ) and hox-6.1 ( mouse ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
117,
122
]
} | {
"id": "C1415652",
"name": "hox",
"pos": [
129,
132
]
} |
hybrid proteins expressed by the lambda gt11 cdna library were blotted onto nitrocellulose filters , and incubated with three different radio-labeled dna probes containing the human epidermal growth factor ( egf ) receptor enhancer or the human c-erbb-2 promoter . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
176,
181
]
} | {
"id": "C0243036",
"name": "erbb",
"pos": [
247,
251
]
} |
the dbpa and dbpb-coded proteins also had an affinity for other cdna probes such as the human c-ski gene , but not for poly ( di-dc ) .poly ( di-dc ) , suggesting that the sequence ( s ) recognized by the dbpa and dbpb-coded proteins may occur frequently , or that these proteins bind to dna non-specifically in a different manner from that of histones . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
88,
93
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
314,
316
]
} |
rabbit polyclonal antibodies ( pab ) were raised against a yeast ras-related protein yp20 and shown to be immunoreactive with human normal as well as altered ha-ras and ki-ras p21 gene products using immunoblotting and immunoprecipitation techniques . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
126,
131
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
172,
175
]
} |
the genome possesses characteristic retrovirus features including structural genes , flanked by long terminal repeats , in the order gag , pol , and env and , in addition , four unique nonstructural genes , several of which appear to be essential in regulating virus replication . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
36,
46
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
139,
142
]
} |
the genome possesses characteristic retrovirus features including structural genes , flanked by long terminal repeats , in the order gag , pol , and env and , in addition , four unique nonstructural genes , several of which appear to be essential in regulating virus replication . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
36,
46
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
149,
152
]
} |
by use of a probe derived from the cloned hst gene , it was shown that additional two transformants ( st7- and st15-derived ) also harboured human hst . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
141,
146
]
} | {
"id": "C0919466",
"name": "hst",
"pos": [
147,
150
]
} |
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