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among 4 primary transformants derived from st1 two did not have human ret oncogene , indicating that other transforming genes were involved in these transformation events .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 64, 69 ] }
{ "id": "C0813143", "name": "ret oncogene", "pos": [ 70, 82 ] }
among 4 primary transformants derived from st1 two did not have human ret oncogene , indicating that other transforming genes were involved in these transformation events .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 64, 69 ] }
{ "id": "C0029016", "name": "transforming genes", "pos": [ 107, 125 ] }
this paper deals with this approach , summarizing and discussing transfection experiments of mouse c-myc and human c-ha-ras-1 cloned oncogenes into mouse embryo balb-3t3 cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 109, 114 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 120, 123 ] }
this paper deals with this approach , summarizing and discussing transfection experiments of mouse c-myc and human c-ha-ras-1 cloned oncogenes into mouse embryo balb-3t3 cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 109, 114 ] }
{ "id": "C0029016", "name": "oncogenes", "pos": [ 133, 142 ] }
the exchange of the n-terminal pentapeptide for the n-terminal pentapeptide of human somatotropin releasing factor ( h-srf ) resulted in a peptide ( [ 1-tyr,2,4-di-ala,5-ile ] secretin ) with practically no srf-activity ( less than 1 % srf-activity up to 100 micrograms/kg in the rat ) , but surprisingly high secretin activity ( almost 100 % in the rat , but only 1150 cu/mg ( 27 % ) in the dog ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 79, 84 ] }
{ "id": "C3538902", "name": "di", "pos": [ 161, 163 ] }
we show here that suramin efficiently reverts the simian sarcoma virus-induced transformed phenotype in human and rat fibroblasts and propose that this is due to neutralization of an externalized v-sis product .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 104, 109 ] }
{ "id": "C0037207", "name": "v-sis", "pos": [ 196, 201 ] }
the human homolog , c-ros , of the transforming gene , v-ros , of the avian sarcoma virus , ur2 , has been isolated from a human genomic library .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0029016", "name": "transforming gene", "pos": [ 35, 52 ] }
the bamhi 6.6 kb band characteristic of human c-ha-ras i was present only in 7402 transformants , but not in phc transformants .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 40, 45 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 51, 54 ] }
deregulation of interleukin-2 receptor expression occurs in t-cell leukemias produced by the human t-lymphotropic retroviruses types i and ii ( htlv-i and -ii ) and has been causally linked to the action of the trans-activator ( taf ) gene of these viruses .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 93, 98 ] }
{ "id": "C1336572", "name": "taf", "pos": [ 229, 232 ] }
this sequence is highly homologous to a human homeo box gene ( hox2 ) and appears to represent one of the two genes in the hox-2 cluster previously assigned to mmu 11 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 40, 45 ] }
{ "id": "C0017347", "name": "homeo box gene", "pos": [ 46, 60 ] }
this sequence is highly homologous to a human homeo box gene ( hox2 ) and appears to represent one of the two genes in the hox-2 cluster previously assigned to mmu 11 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 40, 45 ] }
{ "id": "C3540565", "name": "hox2", "pos": [ 63, 67 ] }
expression of ly-6.2 and thy-1 antigens on nih 3t3 cells suppressed after transformation with activated human ras-oncogenes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 104, 109 ] }
{ "id": "C0034678", "name": "ras-oncogenes", "pos": [ 110, 123 ] }
we have studied the expression of several cell surface antigens in nih 3t3 cells after neoplastic transformation with activated human ras and myc oncogenes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 128, 133 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 134, 137 ] }
we have studied the expression of several cell surface antigens in nih 3t3 cells after neoplastic transformation with activated human ras and myc oncogenes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 128, 133 ] }
{ "id": "C0086661", "name": "myc oncogenes", "pos": [ 142, 155 ] }
the results extend the range of tumor-associated membrane alterations in nih 3t3 cells following transfection with human tumor dna containing activated ras oncogenes by a hitherto unreported alteration in the expression of ly-6 and thy-1 antigens .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 115, 120 ] }
{ "id": "C0034678", "name": "ras oncogenes", "pos": [ 152, 165 ] }
using purified recombinant ras p21 from escherichia coli expressing the full-length t24 mutant human harvey-ras gene protein product as a standard in these rias , we have defined the absolute numbers of pg , fm and molecules of ras p21 in : ( 1 ) e. coli expressing the point-mutated or proto-ras p21 and ( 2 ) mammalian cell lines of human and murine origin .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 95, 100 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 293, 296 ] }
successful fertilization , embryo development , and pregnancy in human in vitro fertilization ( ivf ) using a chemically defined culture medium containing no protein .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 65, 70 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 96, 99 ] }
all human and murine immunoglobulin heavy chain variable region ( vh ) genes contain the sequence atgcaaat approximately 70 nucleotides 5 ' from the site of transcription initiation .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 36, 47 ] }
the chromatin structure of the human c-k-ras gene has been investigated in various cultured normal and tumor human cells and in a rat cell line transformed with the human oncogene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 31, 36 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 171, 179 ] }
binding of h4tf-1 to the distal region of the phu4a histone h4 promoter is inhibited competitively with varying efficiency by four of six human histone h4 genes cloned in this laboratory , whereas efficient competition for binding of h4tf-2 is exhibited by five of the six h4 genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 138, 143 ] }
{ "id": "C1425774", "name": "h4", "pos": [ 273, 275 ] }
since both of these factors bind to significant regions of the phu4a histone h4 promoter and can be bound by several different human h4 genes , we believe that they are important for maximal transcription of the gene and that they may be involved in its regulated expression during the cell cycle .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 127, 132 ] }
{ "id": "C1425774", "name": "h4 genes", "pos": [ 133, 141 ] }
computer analysis of retroviral pol genes : assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes .
organism_has_gene
{ "id": "C0035366", "name": "retroviral", "pos": [ 21, 31 ] }
{ "id": "C0017360", "name": "pol genes", "pos": [ 32, 41 ] }
a human heavy chain variable region subgroup iii pseudogene ( hv3.3 ) was isolated , characterized , and sequenced .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 2, 7 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 8, 19 ] }
the yf subunit , an enzyme found in human tumors and in placenta ( polidoro , g. , di mio , c. , del boccio , g. , zulli , p. , and fererici , g. ( 1980 ) biochem . pharmacol . 29 , 1677-1680 ) has also been shown to be elevated in hepatic preneoplastic lesions ( kitahara , a. , satoh , k. , nishimura , k. , ishikawa , t. , ruike , k. , sato , k. , tsuda , h. , and ito , n. ( 1984 ) cancer res . 44 , 2698-2703 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 36, 41 ] }
{ "id": "C3538902", "name": "di", "pos": [ 83, 85 ] }
the yf subunit , an enzyme found in human tumors and in placenta ( polidoro , g. , di mio , c. , del boccio , g. , zulli , p. , and fererici , g. ( 1980 ) biochem . pharmacol . 29 , 1677-1680 ) has also been shown to be elevated in hepatic preneoplastic lesions ( kitahara , a. , satoh , k. , nishimura , k. , ishikawa , t. , ruike , k. , sato , k. , tsuda , h. , and ito , n. ( 1984 ) cancer res . 44 , 2698-2703 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 36, 41 ] }
{ "id": "C1826259", "name": "mio", "pos": [ 86, 89 ] }
likewise , human egf or human alpha tgf is also able to stimulate the anchorage-dependent growth of normal nmumg cells and nmumg/pyt cells in a serum-free medium supplemented with insulin , transferrin , fetuin , and laminin , or in medium containing low concentrations of serum , whereas these same growth factors under comparable culture conditions have little or no effect upon the anchorage-dependent growth of the ras-transformed nmumg-rash cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 11, 16 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 441, 444 ] }
various protocols using both high and low dose human ril 2 had no antileishmanial effect .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 47, 52 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 53, 56 ] }
the same region also has significant homology with the human d2 germ-line mini-gene sequence , especially with a 14-nucleotide sequence previously shown to be homologous to human and rabbit heavy chain cdr2 sequences .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 55, 60 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 190, 201 ] }
with v-yes dna as the probe , a human cdna library made from placental rna was screened under relaxed conditions , and dna clones derived from a novel genetic locus , termed lyn , were obtained .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 32, 37 ] }
{ "id": "C0812307", "name": "lyn", "pos": [ 174, 177 ] }
in k562 human erythroleukemia cells , which express fetal and embryonic globin genes but not the adult beta-globin gene , the neo gene was expressed strongly from a fetal gamma- or embryonic zeta-globin gene promoter but only weakly from the beta promoter .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 8, 13 ] }
{ "id": "C3825351", "name": "globin genes", "pos": [ 72, 84 ] }
we used human oncogene dna to transform the nontumorigenic , revertant , human osteosarcoma cell line hos te-85 clone 5 ( atcc crl 1543 ) to tumorigenicity in athymic nude mice with latency periods as short as 3 weeks .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 8, 13 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 14, 22 ] }
because of their low rate of spontaneous tumor formation and the simplicity of culturing them , hos cells provide a human cell alternative to nih 3t3 murine fibroblasts for oncogene transfection studies .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 116, 121 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 173, 181 ] }
[ 125i ] 17-alpha-iodovinyl 11-beta-methoxyestradiol interaction in vivo with estrogen receptors in hormone-independent mcf-7 human breast cancer transfected with the v-rash oncogene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 126, 131 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 174, 182 ] }
preincubation of 3h-lps with crude bovine brain gangliosides , as well as purified human brain mono , di , and trisialogangliosides ( gm1 , gd1a , and gt1b , respectively ) , led to an inhibition of the specific binding of lps to the cell surface .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 83, 88 ] }
{ "id": "C3538902", "name": "di", "pos": [ 215, 217 ] }
the ctl were lyt-2+/l3t4- and lysed l cell transfectant clones that expressed the htr gene but not control untransfected l cells or transfectants selected for the expression of an unrelated human cell surface antigen , 4f2 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 190, 195 ] }
{ "id": "C1420192", "name": "4f2", "pos": [ 219, 222 ] }
avirulent mutants were more susceptible to being killed by human neutrophils in vitro ( p less than 0.01 compared to hm1 : imss ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 59, 64 ] }
{ "id": "C1705014", "name": "hm1", "pos": [ 117, 120 ] }
soluble protein preparations from all the avirulent mutants were markedly less mitogenic for human lymphocytes and had lower lectin activity for chinese hamster ovary cells compared to the hm1 : imss wild type ( p less than 0.01 for each activity with each mutant ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 93, 98 ] }
{ "id": "C1705014", "name": "hm1", "pos": [ 189, 192 ] }
this observation questions the general practice of using zona-intact preimplantation mouse embryos to monitor the quality of media and reagents used in human ivf programs .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 152, 157 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 158, 161 ] }
construction of a human ventricular cdna library and characterization of a beta myosin heavy chain cdna clone .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 18, 23 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 87, 98 ] }
this study investigates the influence of antibody protein dose on the radioimmunodetection of a cea-producing , human colonic tumor xenograft ( gw-39 ) using affinity-purified goat anti-carcinoembryonic antigen ( cea ) antibody and a murine monoclonal anti-cea antibody ( np-2 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 112, 117 ] }
{ "id": "C1706141", "name": "np", "pos": [ 272, 274 ] }
an activity that transforms nih 3t3 cells was generated by the in vitro modification of plasmids containing the human c-ha-ras-1 proto-oncogene with the synthesized ultimate carcinogen , 2-acetoxyamino-6-methyldipyrido [ 1,2-a:3',2'-d ] -imidazole ( n-oac-glu-p-1 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 112, 117 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 123, 126 ] }
we have isolated and expressed a cdna clone that encodes a human granulocyte colony-stimulating factor from the mia paca-2 cell line .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 59, 64 ] }
{ "id": "C1417154", "name": "mia", "pos": [ 112, 115 ] }
integration of retroviral dna is a site-specific reaction involving an endonuclease encoded by the viral pol gene ( pol-endo ) .
organism_has_gene
{ "id": "C0035366", "name": "retroviral", "pos": [ 15, 25 ] }
{ "id": "C0017360", "name": "pol", "pos": [ 116, 119 ] }
the expression of several oncogenes is known to be up-regulated during monocytic differentiation of human leukemic cells hl60 , but an alternate pathway of differentiation of these cells , towards the granulocyte , has not been associated with elevated levels of oncogene expression .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 100, 105 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 263, 271 ] }
complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 32, 37 ] }
{ "id": "C1707108", "name": "cdc2", "pos": [ 93, 97 ] }
foveal perceptive fields in the human visual system measured with simultaneous contrast in grids and bars .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 32, 37 ] }
{ "id": "C1707156", "name": "bars", "pos": [ 101, 105 ] }
[ general revision of the genesis of the timbre of human vowels based on the experimental study of physical phenomena having their seat within the pharyngobuccal cavity during phonation ] .
organism_has_gene
{ "id": "C0086418", "name": "general", "pos": [ 2, 9 ] }
{ "id": "C1414672", "name": "genesis", "pos": [ 26, 33 ] }
the human t24 ha-ras1 oncogene : a study of the effects of overexpression of the mutated ras gene product in rodent cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 22, 30 ] }
the human t24 ha-ras1 oncogene : a study of the effects of overexpression of the mutated ras gene product in rodent cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 89, 92 ] }
the human t24 ha-ras1 oncogene was inserted into a high expression vector which carried the aminoglycoside phosphotransferase ( aph ) gene as a selectable market .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 22, 30 ] }
cytogenetical observations in 100 human benign pleomorphic adenomas : specificity of the chromosomal aberrations and their relationship to sites of localized oncogenes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 34, 39 ] }
{ "id": "C0029016", "name": "oncogenes", "pos": [ 158, 167 ] }
human high molecular weight kininogen as a thiol proteinase inhibitor : presence of the entire inhibition capacity in the native form of heavy chain .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 137, 148 ] }
isolation of the bovine and human genes for mullerian inhibiting substance and expression of the human gene in animal cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 28, 33 ] }
{ "id": "C1412384", "name": "genes", "pos": [ 34, 39 ] }
we have isolated the bovine and human genes for mullerian inhibiting substance ( mis ) , a testicular glycoprotein that causes regression of the mullerian duct during development of the male embryo .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 32, 37 ] }
{ "id": "C1412384", "name": "genes", "pos": [ 38, 43 ] }
transcription from the human rrna promoter appears to require an unusual set of protein-dna transactions in which recognition and binding to an upstream cis-control element is carried out by one factor ( ubf1 ) , whereas activation requires an additional factor , sl1 , acting in conjunction with ubf1 to trigger transcription .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 23, 28 ] }
{ "id": "C1421307", "name": "ubf1", "pos": [ 297, 301 ] }
cdna cloning revealed that this mrna encodes a protein of 189 amino acids , identical to that of normal human ha-ras-1 at 185 positions , including positions implicated in oncogenic activation of ras proto-oncogenes ;
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 104, 109 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 196, 199 ] }
the polymorphic restriction fragments of the human ha-ras locus , produced by the variable tandem repetition ( vtr ) of a short consensus sequence , fall into three classes based on allelic frequencies .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 45, 50 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 54, 57 ] }
mouse l cells express a molecular complex carrying the human epitopes recognized by monoclonal antibodies 44d7 and 44h7 after dna-mediated gene transfer .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 55, 60 ] }
{ "id": "C1420192", "name": "monoclonal antibodies 44d7", "pos": [ 84, 110 ] }
recombinant human tumor necrosis factor ( rtnf alpha ) injected intravenously into rabbits produces a rapid-onset , monophasic fever indistinguishable from the fever produced by ril-1 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 12, 17 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 178, 181 ] }
comparison of nucleotide sequences reveals that human , mouse , chicken , and trout c-myc genes contain at least two coding exons , interrupted by introns of decreasing size of 1.38 kilobases ( kb ) , 1.2 kb , 0.97 kb , and 0.33 kb , respectively .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 48, 53 ] }
{ "id": "C0026902", "name": "c-myc", "pos": [ 84, 89 ] }
reduced hormone-stimulated adenylate cyclase activity in nih-3t3 cells expressing the ej human bladder ras oncogene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 89, 94 ] }
{ "id": "C0034678", "name": "ras oncogene", "pos": [ 103, 115 ] }
we determined both in intact nih-3t3 murine cells and in membranes isolated from these cells that the hormone-stimulated adenylate cyclase activity of cells expressing the ej human bladder carcinoma oncogene ( ej-ras ) is significantly reduced compared with control cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 175, 180 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 199, 207 ] }
we determined both in intact nih-3t3 murine cells and in membranes isolated from these cells that the hormone-stimulated adenylate cyclase activity of cells expressing the ej human bladder carcinoma oncogene ( ej-ras ) is significantly reduced compared with control cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 175, 180 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 213, 216 ] }
regional mapping of human chromosome 19 : organization of genes for plasma lipid transport ( apoc1 , -c2 , and -e and ldlr ) and the genes c3 , pepd , and gpi .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 20, 25 ] }
{ "id": "C1412475", "name": "apoc1", "pos": [ 93, 98 ] }
a comparison of the nucleotide and deduced amino acid sequences of the variable regions of six human ti beta cdnas reveals that they display a level of homology similar to that shared by human immunoglobulin heavy chain v genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 95, 100 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 208, 219 ] }
this report presents evidence that multidrug-resistant sublines of human kb carcinoma cells , selected for resistance to either colchicine , vinblastine , or adriamycin ( doxorubicin ) , display amplification of two different dna sequences homologous to the hamster mdr gene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 67, 72 ] }
{ "id": "C0376623", "name": "mdr gene", "pos": [ 266, 274 ] }
the r-protein s14 sequence assigned to human chromosome 5 ( 5q23-5q33 ) rescues chinese hamster emetine-resistance mutations ( emt b ) in interspecific hybrids .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 39, 44 ] }
{ "id": "C3812262", "name": "emt", "pos": [ 127, 130 ] }
the effects of e. coli l-asparaginase on cultured human pancreatic carcinoma ( mia paca-2 ) have been studied .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 50, 55 ] }
{ "id": "C1417154", "name": "mia", "pos": [ 79, 82 ] }
thus , in the intact human heart , digitalis ( 1 ) significantly decreased all measures of ventricular myocardial refractoriness , ( 2 ) had no significant effect on retrograde conduction and refractoriness of the his-purkinje system , and ( 3 ) widened the zone of reentry within the his-purkinje system due to shortening of the functional refractory period of the ventricular muscle with attainment of longer v2-h2 delays .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 21, 26 ] }
{ "id": "C0919509", "name": "h2", "pos": [ 414, 416 ] }
differential staining in the secondary constriction regions of human chromosomes a1 , c9 , and e16 by a heat-hypotonic treatment technique .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 63, 68 ] }
{ "id": "C1442753", "name": "e16", "pos": [ 95, 98 ] }
the secondary constriction ( sc ) regions of human chromosomes a1 , c9 , and e16 were preferentially stained with giemsa when the mitotic cells in a hypotonic solution were heated in a water bath before fixation .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 45, 50 ] }
{ "id": "C1442753", "name": "e16", "pos": [ 77, 80 ] }
binding of aggregated human beta2-microglobulin to surface protein structure in group a , c , and g streptococci .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 22, 27 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 28, 33 ] }
all 10 individual strains of group a streptococci showed a high degree of reactivity with aggregated human beta2-microglobulin .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 101, 106 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 107, 112 ] }
the expression of human beta2-microglobulin ( beta2m ) on human spermatozoa cell surface was investigated by cytotoxicity and immunofluorescence tests .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 18, 23 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 46, 51 ] }
stripping with rabbit anti-human beta2-microglobulin made endothelial cells or monocytes resistant to lysis by endothelial-monocyte antibodies .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 27, 32 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 33, 38 ] }
the regression and turnover of the surface glycoconjugates of trypsin-prepared pig and human cultured epidermal cells have been determined using the glycoprotein precursors n-acetyl-d- ( i-3h ) glucosamine ( 3h-nag ) and n- ( 3h ) -acetyl-d-mannosamine ( 3h-nam ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 87, 92 ] }
{ "id": "C1709111", "name": "nag", "pos": [ 211, 214 ] }
all of the human renin preparations tested cleaved haemoglobin even in the presence o di-isopropylfluorophosphate and ethylenediaminetetra-acetate ( edta ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 11, 16 ] }
{ "id": "C3538902", "name": "di", "pos": [ 126, 128 ] }
surprisingly , human type i fibers , which contained only the slow heavy chain , were found to contain variable amounts of fast myosin light chains in addition to the two slow light chains lc1s and lc2s .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 15, 20 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 67, 78 ] }
thus , in normal human muscle a number of 'hybrid ' myosins were found to occur , namely two extreme forms of fast myosins which have the same light chains but different heavy chains ( iia and iib ) and a continuum of slow forms consisting of the same heavy chain and slow light chains with a variable fast light chain composition .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 17, 22 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 252, 263 ] }
human ia molecules carrying dc1 determinants differ in both alpha- and beta-subunits from ia molecules carrying dr determinants .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1415570", "name": "dc1", "pos": [ 28, 31 ] }
the heavy chains were homogeneous in the initial framework segment and showed a sequence homology of approximately 70 % with the corresponding region of the more recently evolved nurse shark and a 45 % homology with a human myeloma heavy chain .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 218, 223 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 232, 243 ] }
we have previously adapted kety 's tissue autoradiographic method for measuring regional cbf in laboratory animals to the measurement of cbf in humans with positron emission tomography ( pet ) and h2 ( 15 ) o .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 144, 150 ] }
{ "id": "C0919509", "name": "h2", "pos": [ 197, 199 ] }
we then used it in humans to determine the underestimation of cbf that occurs with h2 ( 15 ) o , and thereby were able to calculate the extraction ew and permeability-surface area product psw of h2 ( 15 ) o .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 19, 25 ] }
{ "id": "C0919509", "name": "h2", "pos": [ 195, 197 ] }
prolactin secretion by a human pituitary tumour cell line produced in our laboratory was stimulated by trh , vasoactive intestinal peptide ( vip ) and epithelial growth factor ( egf ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 25, 30 ] }
{ "id": "C1825057", "name": "epithelial growth factor", "pos": [ 151, 175 ] }
in both human and rat cell lines , the increase in ca2+ i produced by trh was independent of extracellular calcium , whereas this was a requirement for the action of vip and egf .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 8, 13 ] }
{ "id": "C1825057", "name": "egf", "pos": [ 174, 177 ] }
the human eosinophil differentiation factor ( edf ) gene was cloned from a genomic library in lambda phage embl3a by using a murine edf cdna clone as a probe .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1708436", "name": "eosinophil differentiation factor", "pos": [ 10, 43 ] }
recombinant human edf , expressed from the human edf gene after transfection into monkey cos cells , stimulated the production of eosinophils and eosinophil colonies from normal human bone marrow but had no effect on the production of neutrophils or mononuclear cells ( monocytes and lymphoid cells ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 12, 17 ] }
{ "id": "C1708436", "name": "edf gene", "pos": [ 49, 57 ] }
analysis of its primary structure shows that stromelysin is in all likelihood the human analog of rat transin , which is an oncogene transformation-induced protease .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 82, 87 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 124, 132 ] }
human fetal lung fibroblasts transformed with simian virus 40 , human bronchial epithelial cells transformed with the ras oncogene , fibrosarcoma cells ( ht-1080 ) , and a melanoma cell strain ( a 2058 ) , do not express this protease nor can the enzyme be induced in these cells by treatment with phorbol 12-myristate 13-acetate .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C0034678", "name": "ras oncogene", "pos": [ 118, 130 ] }
this article reviews the evidence that elevated expression of the human myc gene is involved in sporadic colon carcinoma and familial polyposis coli .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 66, 71 ] }
{ "id": "C0026902", "name": "myc gene", "pos": [ 72, 80 ] }
the somatic loss of heterozygosity for normal alleles occurring in human tumors has suggested the presence of recessive oncogenes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 67, 72 ] }
{ "id": "C0079427", "name": "recessive oncogenes", "pos": [ 110, 129 ] }
these results indicate that features ( for example , knuckle-walking ) unique to african apes ( but not to humans ) are primitive and that even local molecular clocks should be applied with caution .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 107, 113 ] }
{ "id": "C1413503", "name": "clocks", "pos": [ 160, 166 ] }
tissue sections of 120 routinely processed histologically undifferentiated large cell human neoplasms with a histologic differential diagnosis of carcinoma versus lymphoma and/or melanoma were stained with a panel of antibodies composed of monoclonal antikeratin ae1 , monoclonal antileukocyte common antigens pd7/26 and 2b11 , and rabbit anti-s-100 protein .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 86, 91 ] }
{ "id": "C1420193", "name": "ae1", "pos": [ 263, 266 ] }
methods of human sperm preparation for ivf are described and the `` '' ideal '' '' delay between oocyte pick-up and insemination time is discussed , as well as methods to reduce the incidence of polyspermy .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 11, 16 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 39, 42 ] }
the associations of five tissue-specific steroidal disorders with five human neoplasias , as detected in our case-control studies , have been related to the genesis of each tumor .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 71, 76 ] }
{ "id": "C1414672", "name": "genesis", "pos": [ 157, 164 ] }
in membranes prepared from wi-38 human lung fibroblasts , thrombin activated an inositol-lipid-specific plc that hydrolysed [ 32p ] pip2 and [ 32p ] phosphatidylinositol 4-monophosphate ( pip ) to [ 32p ] ip3 and [ 32p ] inositol 1,4-bisphosphate ( ip2 ) respectively .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 33, 38 ] }
{ "id": "C2697645", "name": "ip2", "pos": [ 249, 252 ] }
rodent fibroblast tumours expressing human myc and ras genes : growth , metastasis and endogenous oncogene expression .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 37, 42 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 98, 106 ] }
the effects of expression of human c-myc and both mutated ( t24 ) and normal forms of human ha-ras-1 were studied in an aneuploid rat fibroblast line ( 208f ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 29, 34 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 95, 98 ] }
in contrast to the parental fibroblasts , cells expressing any of the human oncogenes engendered rapidly growing tumours in immune-suppressed animals .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 70, 75 ] }
{ "id": "C0029016", "name": "oncogenes", "pos": [ 76, 85 ] }
of 9 endogenous proto-oncogenes , 7 showed no change in expression from the parental fibroblasts , but c-abl and c-fos were strongly expressed in all cells expressing human ras or myc .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 167, 172 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 173, 176 ] }