text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
thus these tumorigenic cells , although transfected with single human oncogenes , all expressed oncogenes with both nuclear- and membrane-associated products . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
64,
69
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
96,
105
]
} |
the human spleen ferritin -- horseradish peroxidase conjugate ( hrp -- fer ) was synthesized by periodate oxidation of the enzyme carbohydrate fragment . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0812288",
"name": "fer",
"pos": [
71,
74
]
} |
the current study demonstrates a continuous increase in the frequency of leu 11+ ( and cd8+ ) cells and a decline of cd3 and cd4 positive cells during prolonged culture of human pmbl with high levels of ril-2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
172,
177
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
203,
206
]
} |
human globin genes can be transferred into mouse and human erythroid cells in culture , and can be appropriately expressed at the mrna level in these cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
6,
18
]
} |
activation of cellular oncogenes in human and mouse leukemia-lymphomas : spontaneous and induced oncogene expression in murine b lymphocytic neoplasms . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
36,
41
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
97,
105
]
} |
biopsies of 33 malignant human gliomas were karyotyped and evaluated for amplification ( more than eight gene copies per cell ) of the epidermal growth factor receptor ( egfr ) , n-myc , c-myc , and gli genes by southern blot analysis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
25,
30
]
} | {
"id": "C0812287",
"name": "n-myc",
"pos": [
179,
184
]
} |
biopsies of 33 malignant human gliomas were karyotyped and evaluated for amplification ( more than eight gene copies per cell ) of the epidermal growth factor receptor ( egfr ) , n-myc , c-myc , and gli genes by southern blot analysis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
25,
30
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
187,
192
]
} |
biopsies of 33 malignant human gliomas were karyotyped and evaluated for amplification ( more than eight gene copies per cell ) of the epidermal growth factor receptor ( egfr ) , n-myc , c-myc , and gli genes by southern blot analysis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
25,
30
]
} | {
"id": "C1706548",
"name": "gli genes",
"pos": [
199,
208
]
} |
although true in asphyxia , breathing activates lung mechanoreceptors which reduce vagal outflow and apparently , in humans , abolishes sympathetic vasomotor activity ( sna ) . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
117,
123
]
} | {
"id": "C1420267",
"name": "sna",
"pos": [
169,
172
]
} |
the direct action of insulin on human granulosa lutein cells ( glcs ) in long-term cultures obtained from in vitro fertilization ( ivf ) cycles was investigated . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
32,
37
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
131,
134
]
} |
340 bp ( dimer ) and 680 bp ( tetramer ) fractions of the human alphoid satellite dna ( h alpha ri dna ) were isolated after complete cleavage of total human dna with ecor i and cloned in pbr 32.5 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
58,
63
]
} | {
"id": "C1823521",
"name": "pbr",
"pos": [
188,
191
]
} |
we have isolated genomic dna clones which code for the human erythroid membrane protein band 3 ( empb3 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
55,
60
]
} | {
"id": "C1420193",
"name": "erythroid",
"pos": [
61,
70
]
} |
cultured human retinoblastoma cells express the basic fibroblast growth factor ( bfgf ) gene and they produce material similar , if not identical , to bfgf . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
9,
14
]
} | {
"id": "C1708015",
"name": "basic fibroblast growth factor",
"pos": [
48,
78
]
} |
the kinetics of the activation of glu- and lys-plasminogen by single-chain urokinase ( sc urokinase ) derived from the transformed human kidney cell line tcl-598 have been studied and compared with two-chain urokinase ( tc urokinase ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
131,
136
]
} | {
"id": "C1412532",
"name": "tcl",
"pos": [
154,
157
]
} |
a chimeric gene was constructed in which sequences between 253 base pairs ( bp ) upstream of the start of transcription of the human pro-alpha 1 ( i ) collagen gene and 117 bp downstream of that site were fused to the human alpha 1-globin gene , at a site immediately upstream of the globin initiation codon . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
127,
132
]
} | {
"id": "C2697529",
"name": "alpha 1-globin gene",
"pos": [
224,
243
]
} |
we have cultured human wilms ' tumors ( nephroblastomas ) in vitro and examined their growth properties , tumorigenicity in nude mice , karyotypes , and production of a platelet-derived growth factor ( pdgf ) -like activity ( pdgfc ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
17,
22
]
} | {
"id": "C1418436",
"name": "pdgfc",
"pos": [
226,
231
]
} |
granulosa cells were aspirated from human pre-ovulatory follicles following a combined clomiphene-gonadotrophin stimulation in an in-vitro fertilization ( ivf ) programme . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
36,
41
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
155,
158
]
} |
infection of bone marrow or fetal liver cells with abelson murine leukemia virus ( a-mulv ) results in the transformation of pre-b cells and the development of erythroid colonies , indicating that the abl oncogene can affect the growth characteristics of immature cells in both the b cell and erythroid lineages . | organism_has_gene | {
"id": "C0000742",
"name": "abelson murine leukemia virus",
"pos": [
51,
80
]
} | {
"id": "C0080279",
"name": "abl oncogene",
"pos": [
201,
213
]
} |
the formation of leukotriene b4 ( ltb4 ) induced by calcium ionophore a 23187 ( a 23187 ) in human pmn-l was inhibited by 3,5- , 4,5- , and 3,4-di-o-caffeoylquinic acid , caffeoylmalic acid , caffeoyltartric acid , rosmarinic acid , and caffeic acid . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
93,
98
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
144,
146
]
} |
dnas from 253 fresh human tumors of 38 different types were hybridized with 17 different oncogene probes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
20,
25
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
89,
97
]
} |
these data suggest that human r-ras p23 has biochemical properties very similar to those of the p21 products of the h- , k- , and n-ras proto-oncogenes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
24,
29
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
132,
135
]
} |
these data suggest that human r-ras p23 has biochemical properties very similar to those of the p21 products of the h- , k- , and n-ras proto-oncogenes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
24,
29
]
} | {
"id": "C0027260",
"name": "n-ras",
"pos": [
130,
135
]
} |
unlike the human t24 bladder oncogene-encoded p21 , mutant r-ras alleles do not cause monolayer focus formation or growth in soft agar of rat fibroblasts . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
11,
16
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
29,
37
]
} |
unlike the human t24 bladder oncogene-encoded p21 , mutant r-ras alleles do not cause monolayer focus formation or growth in soft agar of rat fibroblasts . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
11,
16
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
61,
64
]
} |
our estimates of n ' obtained with the more reliable data of the higher members of salt series are in the ranges of 19 and 27 amino acid groups , shown by the x-ray crystallographic structure of horse and human hemoglobin of perutz ( perutz , m.f. , et al . ( 1968 ) , nature ( london ) 219 , 131 ) and fermi ( ( 1975 ) j. mol . biol . 97 , 237 ) for the smaller alpha1 beta2 contact areas in the tetrameric structure . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
205,
210
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
370,
375
]
} |
androsterone was reduced with nabh4 and the resulting 3alpha-androstanediol was assayed using human tebg ( sensitivity approximately 200 pg ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
94,
99
]
} | {
"id": "C1366439",
"name": "tebg",
"pos": [
100,
104
]
} |
three radiolabelled proteins : human serum albumin ( 125i-hsa ) , human serum transferrin ( 125i-hst ) and normal rabbit igg ( 125i-rigg ) were tested and it was found that the uptake of each protein markedly increased between 14 and 24 hours of estrogen-activation . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
31,
36
]
} | {
"id": "C0919466",
"name": "hst",
"pos": [
97,
100
]
} |
once exhibitionism is a normal human phenomen , otherwise it is pathological , par example also a neurotic symptom . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
31,
36
]
} | {
"id": "C1417826",
"name": "par",
"pos": [
79,
82
]
} |
in contrast to the human products , the horse smegma fatty acids contained very low odd saturated as well as olefinic branched chain acid contents . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C1415068",
"name": "odd",
"pos": [
84,
87
]
} |
lectin-binding sites of normal retinal pigment epithelium and photo-receptor cells obtained from enucleated human bulbi were identified by a modified pap method . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
108,
113
]
} | {
"id": "C0812382",
"name": "a",
"pos": [
151,
152
]
} |
we have previously shown that in mixed cultures of pbl incubation with human ril-2 induces the rapid expression of il-1 alpha and il-1 beta mrna . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
71,
76
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
77,
80
]
} |
in order to study the involvement of ct-sensitive g proteins in t cell activation , we have utilized ct in an in vitro system in which purified , resting human peripheral t cells are activated by anti-cd3 antibodies and ril-2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
154,
159
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
220,
223
]
} |
to clarify the relationship between oncogene c-sis expression and tumorigenesis in human osteosarcoma , in situ hybridization and immunohistochemical studies were performed to detect c-sis mrna and pdgf-like protein partially consisting of c-sis product . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
83,
88
]
} | {
"id": "C0751995",
"name": "c-sis",
"pos": [
240,
245
]
} |
a highly efficient retroviral vector allows detection of the transforming activity of the human c-fps/fes proto-oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
90,
95
]
} | {
"id": "C1708010",
"name": "fps",
"pos": [
98,
101
]
} |
we have constructed an efficient new retroviral vector containing strong promoting elements derived from the friend murine leukemia virus ( f-mulv ) long terminal repeat ( ltr ) and have used the vector to demonstrate that overexpression of human c-fps/fes can transform established mouse cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
241,
246
]
} | {
"id": "C1708010",
"name": "fps",
"pos": [
249,
252
]
} |
transient expression of the mutated hepatitis b virus c gene in human and mouse cells showed that none of these mutations prevented the secretion of an accurately processed hbe antigen . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
64,
69
]
} | {
"id": "C1415484",
"name": "hbe",
"pos": [
173,
176
]
} |
expression of a human multidrug resistance cdna ( mdr1 ) in the bone marrow of transgenic mice : resistance to daunomycin-induced leukopenia . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
16,
21
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
50,
54
]
} |
the human multidrug resistance gene ( mdr1 ) encodes a drug efflux pump glycoprotein ( p-glycoprotein ) responsible for resistance to multiple cytotoxic drugs . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0376623",
"name": "multidrug resistance gene",
"pos": [
10,
35
]
} |
the human multidrug resistance gene ( mdr1 ) encodes a drug efflux pump glycoprotein ( p-glycoprotein ) responsible for resistance to multiple cytotoxic drugs . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
38,
42
]
} |
a plasmid carrying a human mdr1 cdna under the control of a chicken beta-actin promoter was used to generate transgenic mice in which the transgene was mainly expressed in bone marrow and spleen . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
21,
26
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
27,
31
]
} |
we have recently isolated human and rat cdnas ( designated fer and flk , respectively ) which encode nonreceptor protein-tyrosine kinases which are very similar to one another and related in sequence and domain structure to the c-fps/fes gene product . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C0812288",
"name": "fer",
"pos": [
59,
62
]
} |
we have recently isolated human and rat cdnas ( designated fer and flk , respectively ) which encode nonreceptor protein-tyrosine kinases which are very similar to one another and related in sequence and domain structure to the c-fps/fes gene product . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C1708010",
"name": "fps",
"pos": [
230,
233
]
} |
we show that fer and flk are human and rat counterparts of an evolutionarily conserved gene , hereafter termed fer regardless of species . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
29,
34
]
} | {
"id": "C0812288",
"name": "fer",
"pos": [
111,
114
]
} |
the human and rat fer genes encode a widely expressed 94-kilodalton protein-tyrosine kinase which is antigenically related to the fps/fes protein-tyrosine kinase . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0812288",
"name": "fer genes",
"pos": [
18,
27
]
} |
in order to gain insight on the mechanism ( s ) of the il-2 gene induction , deletions were introduced in the human il-2 gene 5'-flanking region and the mitogen inducibility of each deletion mutant was examined in cultured t cell lines . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
110,
115
]
} | {
"id": "C1708436",
"name": "il-2 gene 5",
"pos": [
116,
127
]
} |
characterization of the human sex hormone binding globulin ( shbg ) gene and demonstration of two transcripts in both liver and testis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
24,
29
]
} | {
"id": "C1366439",
"name": "sex hormone binding globulin",
"pos": [
30,
58
]
} |
this in vitro system may be useful in assessing environmental carcinogens for human epithelial cells and in detecting new human oncogenes since ras oncogenes were not activated in these chemical -- or x-ray -- transformed rhek-1 lines . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
78,
83
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
148,
157
]
} |
this in vitro system may be useful in assessing environmental carcinogens for human epithelial cells and in detecting new human oncogenes since ras oncogenes were not activated in these chemical -- or x-ray -- transformed rhek-1 lines . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
78,
83
]
} | {
"id": "C0034678",
"name": "ras oncogenes",
"pos": [
144,
157
]
} |
in addition , our recent results indicate that nontumorigenic rhek-1 cells can be transformed following transfection with an activated human oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
135,
140
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
141,
149
]
} |
in many human tumors oncogene amplification or activation has been associated with advanced stages of cancer . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
21,
29
]
} |
weaker correlations were also obtained with the sperm penetration assay ( r = 0.42 ) and human ivf ( r = 0.24 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
89,
94
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
95,
98
]
} |
preparation and isolation of antibodies to human mhc class ii alpha chains by aid of synthetic peptides . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
43,
48
]
} | {
"id": "C0017349",
"name": "mhc class ii",
"pos": [
49,
61
]
} |
dna damage induced by ni ( ii ) plus h2o2 was investigated by a dna sequencing technique using 32p-5'-end-labeled dna fragments obtained from human c-ha-ras-1 protooncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
142,
147
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
153,
156
]
} |
limited proteolysis of a recombinant , soluble form of the tac protein , a human interleukin-2 receptor ( ril-2r ) , was performed using trypsin , staphylococcus aureus v8 protease and proteinase k to study the structural requirements of interleukin-2 receptor ( il-2r ) for interleukin-2 ( il-2 ) binding . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
75,
80
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
106,
109
]
} |
the cluster of differentiation 44 ( cd44 ) ag system , originally described in brain and mature t cells , has been subsequently shown to be identical with the human lymphocyte homing-receptor defined by the hermes-1 antibody and to be involved in t cell/endothelial cell interactions in synovium , mucosa , and lymph node . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
159,
164
]
} | {
"id": "C1426009",
"name": "hermes",
"pos": [
207,
213
]
} |
we studied the effects of human ril-1 alpha ( hril-1 alpha ) on intracellular ph ( phi ) and calcium ( [ ca2+ ] i ) in a murine t cell line ( md10 cells ) , which proliferates in response to il-1 alone . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
47,
50
]
} |
by using the intracellularly trapped fluorescent dyes ( 2 ( 1 ) ,7 ( 1 ) -bis-2-carboxyethyl ) -5 ( and -6 ) carboxyfluorescein ) and indo-1 , we monitored immediate to early changes of phi and [ ca2+ ] i in response to hril-1 alpha . | organism_has_gene | {
"id": "C0086418",
"name": "hril-1 alpha",
"pos": [
220,
232
]
} | {
"id": "C1335621",
"name": "hril-1 alpha",
"pos": [
220,
232
]
} |
exposure to hril-1 alpha ( 120 pm ) leads to an early , sustained intracellular alkalinization ( delta ph = + 0.09 +/- 0.03 ) that plateaus within 20 min . | organism_has_gene | {
"id": "C0086418",
"name": "hril-1 alpha",
"pos": [
12,
24
]
} | {
"id": "C1335621",
"name": "hril-1 alpha",
"pos": [
12,
24
]
} |
both the md10 il-1 receptor kd and the hril-1 alpha concentration required to induce early measurable alkaline ph shifts , however , exceed by three orders of magnitude the hril-1 alpha ed50 ( 50 fm ) required for md10 proliferation . | organism_has_gene | {
"id": "C0086418",
"name": "hril-1 alpha",
"pos": [
39,
51
]
} | {
"id": "C1335621",
"name": "hril-1 alpha",
"pos": [
173,
185
]
} |
furthermore , although pma alkalinizes cells previously exposed to hril-1 alpha , the monokine does not alter the phi of pma-treated md10 cells . | organism_has_gene | {
"id": "C0086418",
"name": "hril-1 alpha",
"pos": [
67,
79
]
} | {
"id": "C1335621",
"name": "hril-1 alpha",
"pos": [
67,
79
]
} |
importantly , intracellular alkalinization induced by either hril-1 alpha or pma is inhibited by staurosporine ( 1 mu im ) . | organism_has_gene | {
"id": "C0086418",
"name": "hril-1 alpha",
"pos": [
61,
73
]
} | {
"id": "C1335621",
"name": "hril-1 alpha",
"pos": [
61,
73
]
} |
finally , hril-1 alpha does not change md10 [ ca2+ ] i , in either an acute or sustained fashion . | organism_has_gene | {
"id": "C0086418",
"name": "hril-1 alpha",
"pos": [
10,
22
]
} | {
"id": "C1335621",
"name": "hril-1 alpha",
"pos": [
10,
22
]
} |
injection of human ril-1 alpha in intact normal mice has positive and negative effects on myelopoiesis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
13,
18
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
19,
22
]
} |
study of this basic developmental switch requires the isolation of the testis-determining gene , termed tdf in humans and tdy in mice . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
111,
117
]
} | {
"id": "C1420418",
"name": "tdy",
"pos": [
122,
125
]
} |
the third gene , c-ha-ras 3 , does not contain introns and is a pseudogene , analogous to human c-ha-ras 2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
90,
95
]
} | {
"id": "C0034678",
"name": "ha-ras",
"pos": [
98,
104
]
} |
to study the biosynthesis and assembly of cd4 , wild-type and glycosylation-deficient mutant chinese hamster ovary ( cho ) cells were cotransfected with a cdna encoding cd4 and a cdna for the human multiple drug resistance gene , which allowed the amplification of the transfected cd4 cdna sequences . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
192,
197
]
} | {
"id": "C0376623",
"name": "multiple",
"pos": [
198,
206
]
} |
transcriptional regulatory factors may control the relative expression of human alpha 1 and alpha 2-globin genes in erythroleukemia cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
74,
79
]
} | {
"id": "C2697530",
"name": "alpha 2-globin genes",
"pos": [
92,
112
]
} |
dnase i super-hypersensitive sites direct high level erythroid expression of human alpha- , beta- and beta s- globin genes in transgenic mice . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
77,
82
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
110,
122
]
} |
glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
53,
58
]
} | {
"id": "C0034678",
"name": "ras oncogene",
"pos": [
122,
134
]
} |
the gene related to retinoblastoma ( rb gene ) can be considered a model human tumor suppressor gene and was assigned to band 13q14 , together with the esterase d ( esd ) gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
73,
78
]
} | {
"id": "C0079427",
"name": "tumor suppressor gene",
"pos": [
79,
100
]
} |
cells transfected with vcam-1 bind the human leukemia lines jurkat , ramos , raji , hl60 , and thp1 , but not peripheral blood neutrophils . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
39,
44
]
} | {
"id": "C0812306",
"name": "thp1",
"pos": [
95,
99
]
} |
we have cloned the human jun-b gene and determined its sequence and transforming and trans-activating activities . jun-b is less potent that c-jun in transforming and immortalizing primary rat embryo cells in cooperation with activated ras ( effects enhanced by c-fos and tpa ) ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C0812313",
"name": "jun-b gene",
"pos": [
25,
35
]
} |
we have cloned the human jun-b gene and determined its sequence and transforming and trans-activating activities . jun-b is less potent that c-jun in transforming and immortalizing primary rat embryo cells in cooperation with activated ras ( effects enhanced by c-fos and tpa ) ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
236,
239
]
} |
while these expression and mutation studies support the idea that p21 ras directly regulates metastasis formation , it is also evident that there are many examples of human and murine cancers which show no differences in ras expression in primary and metastatic tumor cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
167,
172
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
221,
224
]
} |
heterogeneity of cell lines derived after transformation of early passage rodent cells by the ha-ras1 human oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
102,
107
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
108,
116
]
} |
to test this hypothesis a double blind randomized placebo controlled trial was conducted where 2 mg purified porcine relaxin or distilled water was given in a vaginal gel on the day of embryo transfer and again 3 days later in a human in vitro fertilization ( ivf ) programme . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
229,
234
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
260,
263
]
} |
thus , porcine relaxin given in these circumstances in a human ivf programme did not appear to improve or interfere with the pregnancy rate . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
57,
62
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
63,
66
]
} |
chromosome mapping of genes on the short arm of human chromosome 11 : parathyroid hormone gene is at 11p15 together with the genes for insulin , c-harvey-ras 1 , and beta-hemoglobin . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
154,
157
]
} |
chromosome mapping of genes on the short arm of human chromosome 11 : parathyroid hormone gene is at 11p15 together with the genes for insulin , c-harvey-ras 1 , and beta-hemoglobin . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C1415481",
"name": "beta-hemoglobin",
"pos": [
166,
181
]
} |
an immunoglobulin epsilon-chain fragment was synthesized in e. coli by cloning and expression of the gene coding for the second , third and fourth constant domains of the human ige heavy chain . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
171,
176
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
181,
192
]
} |
by southern hybridization using a genomic dna fragment carrying a human ige heavy chain constant region gene ( c epsilon ) as a probe , we analyzed the organization of human c epsilon genes and their flanking regions in 23 atopic dermatitis and 6 senile erythroderma patients with elevated serum ige levels , and 6 atopic dermatitis patients with normal ige levels . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
66,
71
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
76,
87
]
} |
the origin of the cyanine dye fluorescence signal in murine and human peripheral blood leukocytes was investigated using the oxa- and indo-carbocyanines di-o-c5 ( 3 ) and di-i-c5 ( 3 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
64,
69
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
171,
173
]
} |
differences in the primary structures of the human cardiac myosins were confirmed by analysis of the peptides produced by limited enzymatic digestion of the heavy chains ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
45,
50
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
157,
169
]
} |
here we show that human hla-a2 and hla-b7 , as well as mouse h-2ld and h-2dd heavy chains expressed after gene transfer in mouse l-cells , associate to a large extent with bovine beta 2-m . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
77,
89
]
} |
the best-characterized example of such a translocation occurs in mouse plasmacytoma and human b-cell lymphoma , where c-myc , the cellular homologue of the viral oncogene myc , is brought into close proximity with either the light- or heavy-chain genes of the immunoglobulin loci , resulting in a change in the regulation of the myc gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
88,
93
]
} | {
"id": "C0086661",
"name": "oncogene myc",
"pos": [
162,
174
]
} |
characterization of an unique rna initiated immediately upstream from human alpha 1 globin gene in vivo and in vitro : polymerase ii-dependence , tissue specificity , and subcellular location . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
70,
75
]
} | {
"id": "C2697529",
"name": "alpha 1 globin gene",
"pos": [
76,
95
]
} |
as neoplastic cells produce high levels of plasminogen activator , it is of interest that aberrations of chromosome 8 have been linked to various leukemias and lymphomas and that two human oncogenes , c-mos and c-myc , have also been mapped to chromosome 8 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
183,
188
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
189,
198
]
} |
as neoplastic cells produce high levels of plasminogen activator , it is of interest that aberrations of chromosome 8 have been linked to various leukemias and lymphomas and that two human oncogenes , c-mos and c-myc , have also been mapped to chromosome 8 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
183,
188
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
211,
216
]
} |
nih-3t3 cells transformed by either the cloned dna of the harvey sarcoma virus or by the t24 human rash oncogene were both tumorigenic after subcutaneous injection and metastatic after intravenous injection . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
93,
98
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
104,
112
]
} |
thus , hla-a , b , c antigen expression on human cytotrophoblasts is limited by the level of hla heavy chain mrna . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
43,
48
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
97,
108
]
} |
both the human and the mouse c-myc genes stimulate clonal growth of 3t3 cells in pdgf-free medium suggesting new strategies for analysis of oncogenes which do not function in focus formation assays . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
9,
14
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
140,
149
]
} |
molecular cloning of the transforming gene from a chemically transformed human osteosarcoma-derived cell line enables the gene to be mapped to chromosome 7 ( 7p11.4-7qter ) and by this criterion and by direct hybridization to be shown to be unrelated to known oncogenes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
73,
78
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
260,
269
]
} |
the murine n-ras gene was cloned by screening an embl-3 recombinant phage library with a human n-ras specific probe . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
89,
94
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
97,
100
]
} |
the proenzyme form of the ca2+-requiring neutral proteinase of human erythrocytes ( procalpain ) is converted to the active proteinase ( calpain ) by low concentrations of ca2+ in the presence of appropriate substrates such as beta-hemoglobin or heme-free beta-globin chains . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
63,
68
]
} | {
"id": "C1415481",
"name": "beta-hemoglobin",
"pos": [
227,
242
]
} |
when lubrol extracts of human erythrocyte membranes were reconstituted with cyc- membranes , the rate of cyclic amp synthesis reached a constant rate after incubation of 80 minutes at 30 degrees c . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
24,
29
]
} | {
"id": "C1426584",
"name": "cyc",
"pos": [
105,
108
]
} |
it is thus concluded that the activity of n-protein in human erythrocyte membrane can be assayed by the adp ribosylation method more simply than by the method of reconstitution of cyc- membranes , with highly close correlation between the values determined by these two methods . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
55,
60
]
} | {
"id": "C1426584",
"name": "cyc",
"pos": [
180,
183
]
} |
this length diversity is formally similar to that found in the human and mouse heavy chain systems , in which it results from interposition of the d element between v and j . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
63,
68
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
79,
90
]
} |
dnas of some human tumours can transform nih 3t3 fibroblast cells , thus demonstrating the transforming potential of human ras genes ( hu-rasha , hu-raski , and hu-rasn , respectively harvey , kirsten and neuroblastoma ras genes ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
13,
18
]
} | {
"id": "C0034678",
"name": "transforming",
"pos": [
91,
103
]
} |
the human multidrug-resistance gene ( mdr1 ) encodes an energy-dependent multidrug efflux protein responsible for the cross-resistance of cultured cells to natural product chemotherapeutic agents such as the anthracyclines and vinca alkaloids . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0376623",
"name": "multidrug-resistance gene",
"pos": [
10,
35
]
} |
the human multidrug-resistance gene ( mdr1 ) encodes an energy-dependent multidrug efflux protein responsible for the cross-resistance of cultured cells to natural product chemotherapeutic agents such as the anthracyclines and vinca alkaloids . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
38,
42
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.