text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the protein-tyrosine kinase activity and hybrid structure of p210bcr/abl are similar to the oncogene product of the abelson murine leukemia virus , p160gag/v-abl , which induces acute lymphomas . | organism_has_gene | {
"id": "C0000742",
"name": "abelson murine leukemia virus",
"pos": [
116,
145
]
} | {
"id": "C0080279",
"name": "v-abl",
"pos": [
156,
161
]
} |
our results demonstrate that human c1s complement cleaves the heavy chain of human class i antigens into at least two fragments , with apparent molecular weights of 22,000 and 24,000 g/mol on sodium dodecyl sulphate-polyacrylamide gel electrophoresis ( sds-page ) , under both reducing and non-reducing conditions . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
29,
34
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
62,
73
]
} |
multidrug resistance phenotype of human bro melanoma cells transfected with a wild-type human mdr1 complementary dna . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
34,
39
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
94,
98
]
} |
we have transfected a eukaryotic expression vector containing a mdr1 complementary dna isolated from normal human liver into human bro melanoma cells to study the drug-resistant phenotype produced by the exclusive overexpression of normal human mdr1 p-glycoprotein . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
108,
113
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
245,
249
]
} |
the studies have also revealed a new class of human oncogenes , the tumor suppressor genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
46,
51
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
52,
61
]
} |
the studies have also revealed a new class of human oncogenes , the tumor suppressor genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
46,
51
]
} | {
"id": "C0079427",
"name": "tumor suppressor genes",
"pos": [
68,
90
]
} |
this inhibitory effect of the e1a proteins is also observed with the ap-1 factor-binding enhansons from the polyomavirus and human metallothionein enhancers , and the mhc class i gene h-2kb enhanson , which binds the kbf1/h2tf1/tc-iib protein . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
125,
130
]
} | {
"id": "C0017355",
"name": "mhc class i gene",
"pos": [
167,
183
]
} |
this inhibitory effect of the e1a proteins is also observed with the ap-1 factor-binding enhansons from the polyomavirus and human metallothionein enhancers , and the mhc class i gene h-2kb enhanson , which binds the kbf1/h2tf1/tc-iib protein . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
125,
130
]
} | {
"id": "C1417708",
"name": "kbf1",
"pos": [
217,
221
]
} |
homologs for five human chromosome 11 and 15 loci ( calc , fes , hras-1 , igflr , tyr ) were localized within an 18-cm span telomeric to lhb . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C0079471",
"name": "hras",
"pos": [
65,
69
]
} |
human rtnf alpha augments anti-bacterial resistance in mice : potentiation of its effects by recombinant human ril-1 alpha . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
111,
114
]
} |
these cells appear to be of human epithelial origin and express high levels of ha-ras transcript . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
28,
33
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
82,
85
]
} |
we now show that purified human ril-6 , when administered alone at relatively high doses that are comparable to therapeutic levels of il-2 , mediated substantial reductions in the number of pulmonary and hepatic micrometastases from four distinct syngeneic tumors . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
32,
35
]
} |
high-resolution mapping of topol cleavages in the regions of human dna including the oncogene c-ha-ras and p53 , has revealed three kinds of topol cleavage sites : cleavage sites not affected by camptothecin ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
61,
66
]
} | {
"id": "C0034678",
"name": "oncogene",
"pos": [
85,
93
]
} |
we examined whether human and mouse spermatozoa release paf during in vitro incubation and assessed the effect of exogenous paf and the paf receptor antagonist web 2086 , a thieno-triazolodiazepine , on mouse in vitro fertilization ( ivf ) rate . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
20,
25
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
234,
237
]
} |
oncogenic activation of the proto-oncogene c-abl in human leukemias occurs as a result of the addition of exons from the gene bcr and truncation of the first abl exon . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
52,
57
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
158,
161
]
} |
a cdna coding for human 5-amino-levulinate dehydratase was placed in a yeast expression vector under the control of the gal10 promoter . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C1707136",
"name": "gal10",
"pos": [
120,
125
]
} |
these data indicate molecular heterogeneity of the human glyr at the level of alpha subunit genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
51,
56
]
} | {
"id": "C1705846",
"name": "at",
"pos": [
62,
64
]
} |
however , not all strains are pathogenic for humans : virulence of strain c may be dependent on its ability both to colonize the intestine and to produce a toxin such as nag-st . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
45,
51
]
} | {
"id": "C1709111",
"name": "nag",
"pos": [
170,
173
]
} |
unfractionated human blood mononuclear cells ( mnc ) from normal and atopic donors cultured in enriched iscove 's modified dulbecco 's medium supplemented with 10 % fcs responded similarly to stimulation with purified human ril-4 ( rhil-4 ) with respect to the concentration required to induce ige synthesis and the magnitude and kinetics of the ige response . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
15,
20
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
224,
227
]
} |
these findings indicate that when normal human t cells are stimulated in vitro in a manner that approximates a physiologic interaction with ag in vivo , ril-4 provides a potent inhibitory signal to il-2 responsive cells that is likely mediated by il-4-induced inhibition of il-2r expression . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
41,
46
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
153,
156
]
} |
human dermal fibroblasts in culture secrete three protein-like neutrophil chemotactic factors , when stimulated either with human ril-1 alpha or il-1 beta ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
130,
133
]
} |
to examine whether a variant human oestrogen receptor gene , which differs from the wild-type gene in the b region , was associated with spontaneous abortion , obstetric histories of breast cancer patients with this variant were compared with those of breast cancer patients with the wild-type gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
29,
34
]
} | {
"id": "C1414461",
"name": "oestrogen receptor gene",
"pos": [
35,
58
]
} |
we examined frozen tissue sections of 50 invasive human breast carcinomas , including 45 ductal , four lobular , and one mucinous tumours , by immunocytochemical methods to determine the in situ distributions of c-erbb-2 , egfr , and pdgfr-beta-subunit . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
50,
55
]
} | {
"id": "C0243036",
"name": "erbb",
"pos": [
214,
218
]
} |
the philadelphia chromosome , widely implicated in human leukaemia , is the result of a reciprocal translocation t ( 9 ; 22 ) ( q34 ; q11 ) in which the abl oncogene located at 9q34 is translocated to chromosome 22q11 , where it is fused head-to-tail with 5 ' exons of the bcr gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
51,
56
]
} | {
"id": "C0080279",
"name": "abl oncogene",
"pos": [
153,
165
]
} |
we obtained human fra-1 cdna clones that can code for a protein of 271 amino acid residues with a calculated molecular weight of 29,413 and showed 90 % similarity with rat fra-1 protein . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
12,
17
]
} | {
"id": "C0812299",
"name": "fra-1",
"pos": [
172,
177
]
} |
characterization of human and mouse c-fes cdna clones and identification of the 5 ' end of the gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
20,
25
]
} | {
"id": "C1704837",
"name": "end",
"pos": [
84,
87
]
} |
by low stringency screening of a xenopus laevis oocyte cdna library with a probe prepared from the yes oncogene of the avian retrovirus y73 , we have isolated clones encoding a 537 amino acid protein with 96 % amino acid identity to the protein product of the human fyn proto-oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
260,
265
]
} | {
"id": "C0812303",
"name": "fyn",
"pos": [
266,
269
]
} |
in the present study , we present the sequence for the human c-abl 3 ' untranslated region ( 3'utr ) and show that while human and murine c-abl cdna sequences are generally homologous , human c-abl transcripts unlike the murine c-abl transcripts do not differ significantly in their 3 ' utrs . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
55,
60
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
230,
233
]
} |
one parent is a synthetically altered harvey murine sarcoma virus rna that lacks a retroviral 3 ' terminus but carries a moloney murine retrovirus-derived envelope gene ( env ) fragment 3 ' of its transforming ras gene . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
136,
146
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
171,
174
]
} |
further , these analyses identify two syntenic clusters of muscle-associated genes on the short arm of human chromosome 11 , one in the region of rhabdomyosarcoma locus that includes igf2 and th and the second the tightly linked myod1 and ldha loci , which have been evolutionarily conserved in homologous regions of both the mouse and the rat genomes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
103,
108
]
} | {
"id": "C1417574",
"name": "myod1",
"pos": [
229,
234
]
} |
a dose-response and time-course study using the rat ectopic bone formation assay revealed that implantation of 0.5-115 micrograms of partially purified recombinant human bmp-2a resulted in cartilage by day 7 and bone formation by day 14 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
164,
169
]
} | {
"id": "C1332424",
"name": "bmp-2a",
"pos": [
170,
176
]
} |
production of il-5 messenger rna by transformed b-cell lines was verified by northern analysis using a 3.2-kilobase cloned dna fragment containing the full-length human il-5 gene , and immunoreactive il-5 was detected in b-cell culture supernatants . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
163,
168
]
} | {
"id": "C1708436",
"name": "il-5 gene",
"pos": [
169,
178
]
} |
suppression of synthesis of specific tropomyosin ( tm ) isoforms occurs commonly in human , murine , and avian fibroblasts transformed by retroviral oncogenes or other modalities . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
84,
89
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
149,
158
]
} |
in this study we have asked whether defects in tm expression had relevance to human neoplasia , which arises most often in cells of the epithelial lineage rather than in fibroblasts and often is unrelated to demonstrable expression of oncogenes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
78,
83
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
235,
244
]
} |
forty-five primary human lung carcinomas were evaluated for the loss of heterozygosity for genes on the short end of chromosome 11 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C1704837",
"name": "genes",
"pos": [
91,
96
]
} |
cultured cell lines and xenografts derived from 7 human medulloblastomas were evaluated for amplification of the c-myc , n-myc , epidermal growth factor receptor , and gli genes by southern blot analysis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
50,
55
]
} | {
"id": "C0812287",
"name": "n-myc",
"pos": [
121,
126
]
} |
cultured cell lines and xenografts derived from 7 human medulloblastomas were evaluated for amplification of the c-myc , n-myc , epidermal growth factor receptor , and gli genes by southern blot analysis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
50,
55
]
} | {
"id": "C1706548",
"name": "gli genes",
"pos": [
168,
177
]
} |
epstein-barr virus ( ebv ) -specific human cytotoxic t lymphocyte ( ctl ) lines from a virus-immune hla-a11+ donor cmc produced significant lysis of transfected mouse p815 target cells ( h-2d background ) expressing an introduced hla-a11 heavy chain gene and the ebv gene encoding latent membrane protein ( lmp ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
37,
42
]
} | {
"id": "C1420192",
"name": "heavy",
"pos": [
238,
243
]
} |
human ( hla-b7 ) and mouse ( h-2dp ) hybrid class i genes , encoding the leader , alpha 1 , and alpha 2 sequences of one species fused to the alpha 3 , transmembrane , and cytoplasmic domains of the other , were transfected into t2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C0017355",
"name": "class i genes",
"pos": [
44,
57
]
} |
the human pthrp gene appears to use multiple promoters and contains alternatively spliced 3 ' exons which give rise to three pthrp mrna classes , each bearing multiple copies of an au motif that has been associated with mrna instability . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1335272",
"name": "pthrp gene",
"pos": [
10,
20
]
} |
we show that one of these clones , clone d , codes for a 5-hydroxytryptamine1a ( 5-ht1a ) binding site since : 1 ) it possesses an intronless open reading frame encoding a protein with seven putative transmembrane domains and 89 % amino acid identity with the human 5-ht1a receptor ( g21 ) ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
260,
265
]
} | {
"id": "C3810555",
"name": "g21",
"pos": [
284,
287
]
} |
human neutrophils exposed to protein-coated polystyrene or cultured endothelial monolayers produce large quantities of h2o2 in response to soluble stimuli that elicit little or no secretion of reactive oxygen species from cells in suspension . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1423498",
"name": "protein-coated",
"pos": [
29,
43
]
} |
these data indicate that most types of human cells are resistant to the e3 19-kda glycoprotein effect , suggesting that virus-specific ctl recognition and lysis of most ad2/5-infected human cells should not be limited by e3 19-kda-mediated reduction in class i mhc ag expression . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
39,
44
]
} | {
"id": "C0017355",
"name": "class i mhc",
"pos": [
253,
264
]
} |
linkage of genetic markers from human chromosome 2q with susceptibility to leprosy or tuberculosis would support both the existence of a susceptibility gene in humans and the contention that this susceptibility gene is a homologue of the mouse bcg locus . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
160,
166
]
} | {
"id": "C0919453",
"name": "susceptibility gene",
"pos": [
196,
215
]
} |
the responses of hypaque-ficoll purified porcine ( p-pmn ) and human neutrophils ( h-pmn ) to stimulation with n-formyl-methionyl-leucyl-phenylalanine ( fmlp ) , c5a , phorbol myristate acetate ( pma ) , and calcium ionophore a23187 ( a23187 ) were compared by flow cytometrically measured changes in the cells ' forward ( fwd-sc ) ( a measure of shape/volume change ) and right angle ( 90 degrees-sc ) light scatter ( a measure of secretion ) , and in the distribution of the membrane potential sensitive fluorescent probe di-o-c ( 3 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
63,
68
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
524,
526
]
} |
neurodegenerative disease induced by the wild mouse ecotropic retrovirus is markedly accelerated by long terminal repeat and gag-pol sequences from nondefective friend murine leukemia virus . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
62,
72
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
129,
132
]
} |
the association of human and bovine beta 2-microglobulins with detergent solubilized hla-a , b antigens was analyzed by a direct binding assay using radiolabeled beta 2-microglobulin and an immunoadsorbent containing a monoclonal antibody to the hla-a , b heavy chains . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
256,
268
]
} |
we examined some of the variables that were possible sources of the wide variability among and within human subjects in their steady-state visual evoked potentials ( vep ) in response to continuously counter-phased visual stimuli ( vertical bars ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
102,
107
]
} | {
"id": "C1707156",
"name": "bars",
"pos": [
241,
245
]
} |
the human analogue of v-sis can be distinguished from its rodent counterparts by southern blotting analysis of ecori-restricted dnas . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0037207",
"name": "v-sis",
"pos": [
22,
27
]
} |
to obtain structural information on this molecule that can be used for comparison with known immunoglobulins and other surface molecules , we isolated the t cell-derived molecule by affinity chromatography using an antiserum raised against the monomeric fab fragment of a human waldenstrom macroglobulin and subjected the isolated molecule to either proteolysis using enzymes or cleavage with cyanogen bromide , followed by isolation of polypeptides which bore the fab- or heavy chain variable region ( vh ) -related antigenic markers . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
272,
277
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
473,
484
]
} |
the results indicated that human dna contains several copies of the c-ras family and that c-ha-ras1 ( with intervening sequences ) was more highly conserved evolutionarily than was c-ha-ras2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
27,
32
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
186,
189
]
} |
a sequence of 14 nucleotides in one human diversity ( d ) minigene ( d2 ) is identical with a sequence in complementarity-determining region 2 ( cdr2 ) of one human gene for the variable region of the heavy chain of immunoglobulin . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
36,
41
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
201,
212
]
} |
another human oncogene , c-sis , is located on chromosome 22 and was recently reported to be transferred to chromosome 9q+ in one cml patient . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
14,
22
]
} |
another human oncogene , c-sis , is located on chromosome 22 and was recently reported to be transferred to chromosome 9q+ in one cml patient . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C0751995",
"name": "c-sis",
"pos": [
25,
30
]
} |
dominant transforming genes that were transferred to mouse nih3t3 cells by cellular dnas prepared from a chemically transformed human cell line ( mnng-hos ) , a human teratocarcinoma cell line ( pa1 ) , and a human pancreatic carcinoma cell line ( a1165 ) were characterized ( a ) analyzing the repetitive human dna sequences that were associated with the transforming gene and ( b ) determining their relationship to the oncogenes of the harvey ( rash ) and kirsten ( rask ) sarcoma viruses and to the human neuroblastoma transforming gene ( rasn ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
128,
133
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
422,
431
]
} |
the human homologs of the raf ( mil ) oncogene are located on human chromosomes 3 and 4 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
38,
46
]
} |
two human genes that are homologous to both the murine transforming gene ( oncogene ) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
243,
252
]
} |
the nucleotide sequences of the six regions within the normal human cellular locus ( c-sis ) that correspond to the entire transforming region of the simian sarcoma virus ( ssv ) genome ( v-sis ) were determined . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
62,
67
]
} | {
"id": "C0751995",
"name": "c-sis",
"pos": [
85,
90
]
} |
the nucleotide sequences of the six regions within the normal human cellular locus ( c-sis ) that correspond to the entire transforming region of the simian sarcoma virus ( ssv ) genome ( v-sis ) were determined . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
62,
67
]
} | {
"id": "C0037207",
"name": "v-sis",
"pos": [
188,
193
]
} |
in contrast to other human tumors in which the c-myc gene and its transcript are greatly amplified , careful analysis of t ( 8 ; 14 ) burkitt cell lines indicates that the c-myc transcript is marginally , and in some cases not at all , increased by comparison to control lymphoblastoid cell lines . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
21,
26
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
172,
177
]
} |
they reacted specifically with multiple human monoclonal and polyclonal igm-rf , independent of any particular light or heavy chain amino acid sequence . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
40,
45
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
120,
131
]
} |
in particular , the majority of murine plasmacytomas and human burkitt 's lymphomas contain a characteristic translocation which results in the juxtaposition of a cellular oncogene , c-myc , with the immunoglobulin heavy-chain gene locus , and this rearranged c-myc directs the synthesis of qualitatively and quantitatively abnormal transcripts which may have an aetiological role in the development of the transformed state in lymphoid malignancies . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
57,
62
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
260,
265
]
} |
based on the conservation of these human sequences in mouse fibroblast transformants , we conclude that the transforming ability of the oncogene activated in these tumors resides within a 43- to 46-kilobase-pair dna region . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
35,
40
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
136,
144
]
} |
such a mechanism is in direct contrast to that of putative human oncogenes which are thought to induce tumorigenesis following activation or alteration . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
59,
64
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
65,
74
]
} |
nucleotide sequences of the human alpha 1 and two allelic alpha 2 immunoglobulin heavy chain constant region genes are presented . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
28,
33
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
81,
92
]
} |
the following procedures were associated with high rates of mouse embryo development and human pregnancies following ivf-et : adequate gassing and equilibration of the medium , double rinsing of pipettes and catheters used to handle embryos , use of a hepes-buffered medium for manipulating embryos in the absence of an atmosphere containing 5 % co2 , control of excessive temperature in the vicinity of the embryos , and et using medium containing 50 % patient 's serum . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
89,
94
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
117,
120
]
} |
we tested the effectiveness of dihydroxyanthracenedione ( dhad ) on cell growth of two human pancreatic carcinoma cell lines mia paca-2 and panc-1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
87,
92
]
} | {
"id": "C1417154",
"name": "mia",
"pos": [
125,
128
]
} |
substantial amounts of human heavy chain accumulated in the transformed cells , and hla antigen was present at the cell surface . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
23,
28
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
29,
40
]
} |
using human-mouse somatic cell hybrids containing different parts of chromosome 6 and a dna probe of the oncogene ( v-myb ) of avian myeloblastosis virus ( amv ) , we regionally mapped by southern blot techniques the human cellular myb ( c-myb ) protooncogene to 6q21 -- -- qter . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
6,
11
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
251,
259
]
} |
using human-mouse somatic cell hybrids containing different parts of chromosome 6 and a dna probe of the oncogene ( v-myb ) of avian myeloblastosis virus ( amv ) , we regionally mapped by southern blot techniques the human cellular myb ( c-myb ) protooncogene to 6q21 -- -- qter . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
6,
11
]
} | {
"id": "C0026900",
"name": "v-myb",
"pos": [
116,
121
]
} |
a human h4 histone gene was isolated and the nucleotide sequences of the mrna coding as well as the 5 ' and 3 ' flanking regions were determined . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
2,
7
]
} | {
"id": "C1425774",
"name": "h4",
"pos": [
8,
10
]
} |
similar blot hybridizations with a probe specific for the human n-ras oncogene detected a 9-kilobase ecori fragment in all cases . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
58,
63
]
} | {
"id": "C0027260",
"name": "n-ras oncogene",
"pos": [
64,
78
]
} |
two lines of evidence suggest that these genes may play a role in the development of human malignancy : ( 1 ) dna from a variety of human tumors transforms nih 3t3 mouse fibroblasts and the transforming genes from a number of carcinomas , sarcomas , and hematological malignancies have been identified as members of a family of genes , the ras family , closely related to the oncogenic genes of the harvey and kirsten murine sarcoma viruses ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
85,
90
]
} | {
"id": "C0029016",
"name": "transforming genes",
"pos": [
190,
208
]
} |
two lines of evidence suggest that these genes may play a role in the development of human malignancy : ( 1 ) dna from a variety of human tumors transforms nih 3t3 mouse fibroblasts and the transforming genes from a number of carcinomas , sarcomas , and hematological malignancies have been identified as members of a family of genes , the ras family , closely related to the oncogenic genes of the harvey and kirsten murine sarcoma viruses ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
85,
90
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
340,
343
]
} |
nag vibrios isolated from humans were sensitive to phages tepv in 45 % of cases and nag vibrios isolated from the environment , only in 29.9 % of cases . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
26,
32
]
} | {
"id": "C1709111",
"name": "nag",
"pos": [
84,
87
]
} |
a relation between this translocation and the location of the human oncogene c-sis on the chromosome 22 should be considered . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
62,
67
]
} | {
"id": "C0037207",
"name": "oncogene",
"pos": [
68,
76
]
} |
northern blot analysis has now shown that in the mcp6 hybrid , human class i genes , i.e. , hla-a , b , c , continued to be transcribed , and cellular levels of the transcripts were similar to , or only slightly lower than , levels in hybrids with a non-ec phenotype . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
63,
68
]
} | {
"id": "C0017355",
"name": "class i genes",
"pos": [
69,
82
]
} |
in the normal human ovary , surface epithelial cells , mature granulosa cells and lutein cells reacted with anti-hla-a , b , c ( hla ) and beta2-microglobulin antibodies but not with anti-ia ( ia-like , hla-dr ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
14,
19
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
139,
144
]
} |
activated toxin preparations catalyzed adp-ribosylation of a protein ( mr = 40,000 ) present in cell membrane preparations obtained from human red blood cells and platelets , rat adipocytes , and cyc- s49 cells which are deficient in the adenylate cyclase regulatory component which is the substrate for cholera toxin . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
137,
142
]
} | {
"id": "C1426584",
"name": "cyc",
"pos": [
248,
251
]
} |
although the ch1 domains of the five classes of human heavy chains have the expected degree of homology ( approximately 30 % ) , the homology of the c delta 1 domains of the human and mouse chains is less than that exhibited by the ch1 domains of other pairs of human and mouse heavy chains . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C1420192",
"name": "heavy",
"pos": [
278,
283
]
} |
antigens associated with the epstein-barr virus ( ebv ) replicative cycle were found in the nucleus and cytoplasm of human placental , vero , bsc-1 , and owl monkey kidney cells transfected with ebv dna prepared from several different strains of virus . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
117,
122
]
} | {
"id": "C1420091",
"name": "bsc",
"pos": [
142,
145
]
} |
the influence of the following affinity labeling reagents on the binding of tritiated estradiol-17 beta ( e ) by human and calf uterine cytosols was studied : 11 beta-chloromethylestradiol ( org4333 ) , 2-azidoestradiol ( 2a-e ) , 4-azidoestradiol ( 4a-e ) , 3-azidohexestrol ( 3a-h ) , estradiol-17 beta 17-bromoacetate ( e-17brac ) , 6- [ o-carbo- ( 2'-chloroethoxy ) methyl ] oximinoestradiol ( 6-cmoetc1 ) , 17- [ o-carbo- ( 2'-chloroethoxy ) methyl ] oximinoestrone ( 17-cmoetcl ) , 2-di ( 2'-hydroxy-3'-chloropropyl ) aminoestradiol ( e-mustard ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
113,
118
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
534,
536
]
} |
the amount of cross-hybridization between the human and rabbit alpha-globin mrna and the two alpha-globin cdnas was comparable to the cross-hybridization between the two beta-globin mrnas and the two beta-globin cdnas , indicating a similar degree of evolutionary divergence in the nucleotide sequences of the two globin genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
46,
51
]
} | {
"id": "C3825351",
"name": "globin genes",
"pos": [
314,
326
]
} |
however , treatment of sensitized cells with htla + c ' had little effects on the release of mif and lt . | organism_has_gene | {
"id": "C0086418",
"name": "htla",
"pos": [
45,
49
]
} | {
"id": "C3538735",
"name": "mif",
"pos": [
93,
96
]
} |
purified human and rat plasma rbp have a single binding site for one molecule of retinol , alpha mobility on disc gel electrophoresis , and a molecular weight of approximately 20,000 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
9,
14
]
} | {
"id": "C1419320",
"name": "plasma rbp",
"pos": [
23,
33
]
} |
multiple common properties of human beta2-microglobulin and the common portion fragment derived from hl-a antigen molecules . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
30,
35
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
36,
41
]
} |
evolutionary relationship between carboxyterminal region of a human alpha chain and other immunoglobulin heavy chain constant regions . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
62,
67
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
105,
116
]
} |
although human toxicity from exposure to the plasticizer di ( 2-ethylhexyl ) phthalate ( dehp ) is unknown , reports of animal toxicity from dehp have stimulated extensive toxicological studies . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
9,
14
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
189,
191
]
} |
human ia molecules carrying dc1 or br4x7 determinants are not homologous to murine i-e molecules . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1415570",
"name": "dc1",
"pos": [
28,
31
]
} |
the extracellular matrix , prepared by extraction of confluent cultures of human lung wi-38 fibroblasts with a dipolar tonic detergent , contains four major glycoproteins : fibronectin , gp250 , gp170 , and gp140 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
75,
80
]
} | {
"id": "C0376622",
"name": "gp170",
"pos": [
195,
200
]
} |
a striking similarity between the cytokeratins of human basal-cell epitheliomas and those of the pilosebaceous tract has been found : all three major cytokeratins ( mol wts 58,000 ; 50,000 ; 46,000 ) of the tumor cells are also expressed in hair-follicle epithelium . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
50,
55
]
} | {
"id": "C1705714",
"name": "wts",
"pos": [
169,
172
]
} |
because a direct relationship exists between the ed50 values obtained from these discrimination studies and human hallucinogenic potencies , the discriminative stimulus paradigm , with dom as a training drug , appears to be a useful tool for comparing the quantitative and qualitative ( dom-like ) effects produced by certain hallucinogenic agents . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
108,
113
]
} | {
"id": "C3539821",
"name": "dom",
"pos": [
287,
290
]
} |
we investigated the presumed anion-binding domain of the anion-transport protein from human erythrocyte membranes , using 2,6-di-iodo-4-sulphophenyl isothiocyanate , an inhibitor of anion transport . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
86,
91
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
126,
128
]
} |
cultured human pancreatic carcinoma cells ( mia paca-2 ) have been shown previously to be very sensitive to e. coli l-asparaginase ( ec ii ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
9,
14
]
} | {
"id": "C1417154",
"name": "mia",
"pos": [
44,
47
]
} |
by thin-layer chromatographic behaviour and gas-liquid chromatographic determinations the main gangliosides in human kidney are n-acetylneuraminyllactosylceramide ( 74 % of total ) and di-n-acetylneuraminyllactosylceramide ( 19 % of total ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
111,
116
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
185,
187
]
} |
polyglutamate derivatives of labelled methotrexate were formed by human lymphocytes with mean amounts of 4-5 % of di- , 1-5 % of tri- , 1-0 % of tetra- and 0-7 % of penta-glutamate derivatives being formed over the period 48-72h of culture . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
66,
71
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
114,
116
]
} |
while they have no effect on the transport of na in human and cat red cells , in dog red cells adenosine and its mono- , di- and triphosphorylated forms were found to increase na-influx . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
52,
57
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
121,
123
]
} |
incubation of human monocytes with alpha-l-fucosidase , a glycosidase which cleaves terminal l-fucose moieties , reversibly prevented their response to mif . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
14,
19
]
} | {
"id": "C3538735",
"name": "mif",
"pos": [
152,
155
]
} |
preliminary analysis of the 5'-termini of the 18-s rna from human , rat , xenopus and sea urchin cells revealed the same pup ( np ) gp -- - type 5'-terminal structure , supporting the above hypothesis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
60,
65
]
} | {
"id": "C1706141",
"name": "np",
"pos": [
127,
129
]
} |
the guinea pig protein closely resembles the human and rabbit beta2-microglobulins in amino acid composition , charge , molecular size , and also in the presence of an apparently analogous disulfide loop . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
45,
50
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
62,
67
]
} |
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