text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
physical-chemical studies suggest that human beta2-microglobulin and isolated immunoglobulin domains are similar not only in amino acid sequence but also in three-dimensional structure . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
39,
44
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
45,
50
]
} |
rabbit antiserum to human beta2-microglobulin was used to inhibit the proliferative response of lymphocytes in a variety of in vitro assays and to block the effector phase of the cell mediated lympholysis reaction . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
20,
25
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
26,
31
]
} |
a fowl antiserum to human polyclonal f ( ab ' ) 2 with specificities for variable region antigens of both light and heavy chains and for the constant portion of the fd fragment bound to about 20 per cent of thymocytes from three children . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
20,
25
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
116,
128
]
} |
these findings from unmanipulated human neuroblastomas indicate that the ha-ras gene product ( p21 ) might play a role in the mechanism ( s ) controlling aggressiveness in this type of tumor in vivo and that the ha-ras p21 detected by a simple and reproducible immunohistochemical procedure may be of clinical importance in predicting prognosis in patients with this malignancy . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
34,
39
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
215,
218
]
} |
in the course of identifying genes from human tumors capable of conferring resistance to cp , we tested the ability of several types of cellular and viral ras oncogene ( h , k , and n ) to alter the cp response of mouse cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
40,
45
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
155,
158
]
} |
supernatants from pha-activated human peripheral blood mononuclear cells , depleted of virtually all il-2 activity by an anti-ril-2 immunoadsorbent column , contain a factor ( s ) which synergizes with ril-2 in facilitating the generation of allogeneic human ctl responses in vitro . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
32,
37
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
202,
205
]
} |
the direct binding protein ( s ) of ras p21 was ( were ) investigated in inside-out vesicles of human erythrocyte ghosts using the pure v-kirsten ( ki ) -ras p21 synthesized in e. coli . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
96,
101
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
154,
157
]
} |
the human progesterone receptor gene was localized by in situ hybridization to the q22 band of chromosome 11 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1366500",
"name": "progesterone receptor gene",
"pos": [
10,
36
]
} |
human serum was found to contain a variety of class i-like molecules by western blotting with anti-class i heavy chain reagents : major bands usually are observed around mr 44,000 , 40,000 , and 35,000-37,000 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
107,
118
]
} |
sera from hartley guinea pigs vaccinated with a veterinary live spore anthrax vaccine were compared with sera from guinea pigs vaccinated with the human anthrax vaccine , which consists of aluminum hydroxide-adsorbed culture proteins of bacillus anthracis v770-np-1r . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
147,
152
]
} | {
"id": "C1706141",
"name": "np",
"pos": [
261,
263
]
} |
we have cloned and sequenced the full-length cdna for the human cation-independent mannose 6-phosphate receptor from four overlapping clones . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
58,
63
]
} | {
"id": "C1334090",
"name": "cation-independent mannose 6-phosphate receptor",
"pos": [
64,
111
]
} |
the nucleotide sequence for the full-length cdna and the deduced amino acid sequence for the cation-independent mannose 6-phosphate receptor , which are reported here , are strikingly similar ( 99.8 % identical at the nucleotide level and 99.4 % identical at the amino acid level ) to those recently reported for the human insulin-like growth factor ii receptor from hepg2 hepatoma cells ( morgan , d. o. , edman , j.d. , standring , d. n. , fried , v. a. , smith , m. c. , roth , r. a. , and rutter , w. j . ( 1987 ) nature 329 , 301-307 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
317,
322
]
} | {
"id": "C1334090",
"name": "insulin-like growth factor ii receptor",
"pos": [
323,
361
]
} |
a reliable method for the analysis of human mhc class ii alpha and beta chains by western blotting of ief gels . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
38,
43
]
} | {
"id": "C0017349",
"name": "mhc class ii",
"pos": [
44,
56
]
} |
investigation of the ets-1 expression levels in human leukemic samples showed that primary malignant t cells ( t-alls ) , corresponding to intrathymic stages of maturation , have a much higher level of ets-1 mrna than malignant t lymphoid cells with a mature phenotype , such as adult t cell leukemias ( atls ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C0812201",
"name": "ets-1",
"pos": [
202,
207
]
} |
the successful cloning , sequencing and expression of the human glucocorticoid ( hgr ) ( ref . 1 ) , oestrogen ( her ) , progesterone ( hpr ) , and mineralocorticoid ( hmr ) receptors , complementary dna , plus homologues from various species , provides the first opportunity to study receptor structure and its influence on gene expression . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
58,
63
]
} | {
"id": "C1367453",
"name": "hmr",
"pos": [
168,
171
]
} |
we determined which viral oncogenes ( v-sis , v-myc , and v-fos ) were expressed in five primary human brain tumors of neuroectodermal origin ( two glioblastomas multiforme , one medulloblastoma , one cystic cerebellar astrocytoma , and one ganglioglioma ) and which of these oncogenes is correlated with malignancy . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
97,
102
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
276,
285
]
} |
small cytoplasmic ro rna pseudogene and an alu repeat in the human alpha-1 globin gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
61,
66
]
} | {
"id": "C2697529",
"name": "alpha-1",
"pos": [
67,
74
]
} |
the biological role of amino acid differences between the human 21-kda ha-ras protein ( p21 ) and the human 23-kda r-ras protein ( p23 ) was investigated by engineering mutant ha-ras p21 molecules containing divergent amino acid sequences from r-ras p23 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
58,
63
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
246,
249
]
} |
proliferation of hl-60 cells in culture was inhibited in a sequence-specific , dose-dependent manner by the c-myc-complementary oligomer , but neither the oligomer complementary to vesicular stomatitis virus matrix protein mrna nor 5 ' d ( catttcttgctctcc ) 3 ' , complementary to nucleotides 5399-5413 of human immunodeficiency virus tat gene mrna , inhibited proliferation . | organism_has_gene | {
"id": "C0019682",
"name": "human immunodeficiency virus",
"pos": [
306,
334
]
} | {
"id": "C0017375",
"name": "tat gene",
"pos": [
335,
343
]
} |
two human pancreatic cancers grown in nude mice were studied : ski , which has cholecystokinin receptors , and cav , which does not . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1707075",
"name": "cav",
"pos": [
111,
114
]
} |
nih-3t3 cells expressing elevated levels of the normal human c-ha-ras proto-oncogene ( c-ras ) exhibit reduced platelet derived growth factor-stimulated phospholipase activity . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
55,
60
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
89,
92
]
} |
the human fetal-to-adult globin switch normally occurs on a fixed schedule , beginning at 32-34 weeks gestation , and recent studies have suggested an association between this developmental inactivation of the fetal ( gamma ) globin genes and the appearance of methylation within and around these genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C3825351",
"name": "globin",
"pos": [
226,
232
]
} |
anti-tac only partially inhibited proliferation induced by either okt3 or okt3 + pma , but consistently prevented it when pbl were stimulated by pma plus exogenous human ril-2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
164,
169
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
170,
173
]
} |
cell surface expression and alloantigenic function of a human class i mhc heavy chain gene ( hla-b7 ) in transgenic mice . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
56,
61
]
} | {
"id": "C1420192",
"name": "heavy",
"pos": [
74,
79
]
} |
we have introduced the gene encoding the heavy chain of the human mhc class i ag hla-b7 into transgenic mice . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
60,
65
]
} | {
"id": "C0017355",
"name": "mhc class i",
"pos": [
66,
77
]
} |
southern blots of human , mouse , and chicken dna demonstrate that jun-b and c-jun are different genes and that there may be other vertebrate genes related to jun-b and c-jun . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C0162508",
"name": "c-jun",
"pos": [
169,
174
]
} |
no apparent difference in the degree of responsiveness to prostaglandin e , gamma-interferon , or human heavy chain ( acidic ) ferritin was noted in the presence of pokeweed mitogen-stimulated mouse spleen conditioned medium , granulocyte-macrophage colony-stimulating factor , or macrophage colony-stimulating factor . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
98,
103
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
104,
115
]
} |
the results suggest that tnf-alpha , human heavy chain ( acidic ) ferritin , gamma-interferon , and prostaglandin e can act directly at the progenitor cell level . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
37,
42
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
43,
54
]
} |
dz alpha was assumed to correspond to the human dz alpha gene while the other two were designated dy because their relationship to human class ii genes could not be firmly established . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
42,
47
]
} | {
"id": "C0017349",
"name": "class ii genes",
"pos": [
137,
151
]
} |
nih 3t3 cells transformed with the human c-ha-rasval-12 oncogene showed markedly enhanced activity of ornithine decarboxylase ( odc ) , the key enzyme of polyamine biosynthesis , as compared with their nontransformed counterparts . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
35,
40
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
56,
64
]
} |
in the course of these experiments , we found also that human skin fibroblasts , which do not contain detectable amounts of hla-dr-alpha mrna , spontaneously transcribe the hla-dr-alpha gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
56,
61
]
} | {
"id": "C1415575",
"name": "hla-dr-alpha gene",
"pos": [
173,
190
]
} |
in the present study , we investigated the role of cd4 in the different phases of the cytolytic reaction mediated by human cd4+ class ii mhc-specific ctl clones by using a single cell assay . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
117,
122
]
} | {
"id": "C0017349",
"name": "class ii mhc",
"pos": [
128,
140
]
} |
a retrovirus packaging cell line was constructed by using portions of the moloney murine leukemia virus in which the gag , pol , and env genes of the helper virus were separated onto two different plasmids and in which the psi packaging signal and 3 ' long terminal repeat were removed . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
2,
12
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
123,
126
]
} |
a retrovirus packaging cell line was constructed by using portions of the moloney murine leukemia virus in which the gag , pol , and env genes of the helper virus were separated onto two different plasmids and in which the psi packaging signal and 3 ' long terminal repeat were removed . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
2,
12
]
} | {
"id": "C0017343",
"name": "env genes",
"pos": [
133,
142
]
} |
the highly oncogenic avian retrovirus reticuloendotheliosis virus strain t ( rev-t ) contains a substitution of the oncogene v-rel for much of env and a deletion of gag and pol relative to the helper virus rev-a . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
27,
37
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
143,
146
]
} |
the highly oncogenic avian retrovirus reticuloendotheliosis virus strain t ( rev-t ) contains a substitution of the oncogene v-rel for much of env and a deletion of gag and pol relative to the helper virus rev-a . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
27,
37
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
173,
176
]
} |
in addition , the immunosuppressive peptide sequence common to many retroviruses was found in the env region of sm-mtv . | organism_has_gene | {
"id": "C0035366",
"name": "retroviruses",
"pos": [
68,
80
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
98,
101
]
} |
a fragment of the human c-ki-ras1 pseudogene ( hgm9 gene symbol kras1p ) , localized to 6p12-p11 , detects 3 allele , rflp . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C1537502",
"name": "kras1p",
"pos": [
64,
70
]
} |
therefore , igf-ii transcripts detected may be products of alternative splicing as their 5'-utr sequence is contained within the human igf-ii gene or they may be a consequence of alternative promoter utilization in placenta . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
129,
134
]
} | {
"id": "C1334091",
"name": "igf-ii gene",
"pos": [
135,
146
]
} |
the results show that normal attenuation values for human liver are 0.054 +/- 0.009 np/cm-mhz ( 0.47 db/cm-mhz ) with a frequency dependence of fn , where n = 1.05 +/- 0.25 , in agreement with in vitro studies of mammalian liver . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
52,
57
]
} | {
"id": "C1706141",
"name": "np",
"pos": [
84,
86
]
} |
on western blots 5-10 ng of purified human platelet tgf-beta 1 could be detected when probed with affinity-purified peptide antisera generated against peptides corresponding to residues 48-77 , 50-75 , and 78-109 of the 112 amino acid tgf-beta 1 monomer . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
37,
42
]
} | {
"id": "C1366557",
"name": "tgf-beta 1",
"pos": [
235,
245
]
} |
the proteins coded for by the human tgf-beta 1 and tgf-beta 2 cdnas show an overall homology of 41 % . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
30,
35
]
} | {
"id": "C1366557",
"name": "tgf-beta 1",
"pos": [
36,
46
]
} |
early following mitogenic activation , normal human t cells express elevated levels of steady-state mrnas encoding the nuclear-localized protooncogenes , c-fos , c-myc , and c-myb . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
46,
51
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
162,
167
]
} |
further , the spermatozoa from 50 ( 78.1 % ) of the 64 ejaculates filtered through glass wool column fertilized at least one intact human egg in an in-vitro fertilization ( ivf ) procedure . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
132,
137
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
173,
176
]
} |
these techniques have proved to be of value in predicting the ability of patients ' spermatozoa to fertilize the human ovum in vitro and in the evaluation of techniques and reagents of relevance to the therapeutic application of ivf , including sperm preparation protocols and reagents for the artificial enhancement of sperm function . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
113,
118
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
229,
232
]
} |
several different rat anti-peptide antisera have been used to confirm the presence of human ril-3 immunochemically . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
86,
91
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
92,
95
]
} |
human ril-3 expressed in cos7 cells has multipotential csf activity in semisolid cultures of bone marrow cells , and selectively induced the proliferation of my-10+ marrow or cord blood cells in liquid cultures . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
6,
9
]
} |
we have investigated the ability of porcine-platelet-derived transforming growth factor-beta 1 ( tgf-beta 1 ) to inhibit the generation of lymphokine-activated killer ( lak ) cells by human ril-2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
184,
189
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
190,
193
]
} |
additional studies demonstrated that porcine platelet-derived tgf-beta 2 and human rtgf-beta 1 inhibited lak cell generation similar to that obtained with tgf-beta 1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
77,
82
]
} | {
"id": "C1366557",
"name": "tgf-beta 1",
"pos": [
155,
165
]
} |
mouse cells labeled with fluorescent human b2m were recognized by mab to the class i mhc ag and by virus-restricted cytotoxic t lymphocytes , suggesting that labeling with the fluorescent b2m does not significantly alter the structure of class i mhc ag or impair their ability to present viral antigens to cytotoxic t lymphocytes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
37,
42
]
} | {
"id": "C0017355",
"name": "class i mhc",
"pos": [
238,
249
]
} |
in most human burkitt 's lymphomas , translocation of the myc oncogene to an immunoglobulin locus is associated with loss of myc exon 1 or with mutations near its 3 ' border , a region where myc transcription is attenuated and translation of a larger myc polypeptide initiates . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
62,
70
]
} |
human observers fixated the center of a search array and were required to discriminate the color of an odd target if it was present . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1415068",
"name": "odd",
"pos": [
103,
106
]
} |
injection of either recombinant human interleukin 1 alpha ( ril-1 alpha ) or interleukin 1 beta ( ril-1 beta ) directly into preformed air pouches caused a 10- to 100-fold increase in the number of white blood cells present within the pouch . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
32,
37
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
98,
101
]
} |
polymorphonuclear neutrophils ( pmn ) represented the majority of cells entering the pouch following either a single injection or repeated daily injections of ril-1 alpha or ril-1 beta . | organism_has_gene | {
"id": "C0086418",
"name": "ril-1 alpha",
"pos": [
159,
170
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
174,
177
]
} |
increases in levels of procollagenase mrna in human fibroblasts induced by interleukin-1 , tumor necrosis factor-alpha , or serum follow c-jun expression and are dependent on new protein synthesis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
46,
51
]
} | {
"id": "C0162508",
"name": "c-jun",
"pos": [
137,
142
]
} |
clonal stimulation or inhibition of human colon carcinomas and human renal carcinomas mediated by transforming growth factor-beta 1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
36,
41
]
} | {
"id": "C1366557",
"name": "transforming growth factor-beta 1",
"pos": [
98,
131
]
} |
using recently established human colon carcinoma and renal cell carcinoma under defined in vitro conditions , we observed intertumoral and intratumoral heterogeneity and polarity of responses to tgf-beta ( growth inhibition or stimulation ) that did not correlate with the metastatic phenotype of the cancer cells as assessed in athymic nude mice . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
27,
32
]
} | {
"id": "C1366557",
"name": "tgf-beta",
"pos": [
195,
203
]
} |
novel human mhc class i genes are expressed by tumour cell lines representing embryonic and extraembryonic tissues . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
6,
11
]
} | {
"id": "C0017355",
"name": "mhc class i genes",
"pos": [
12,
29
]
} |
human breast carcinoma cell levels of mdr-1 ( p-glycoprotein ) transcripts correlate in vivo inversely and reciprocally with tumor progesterone receptor content . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C0376622",
"name": "mdr-1",
"pos": [
38,
43
]
} |
deletions and translocations involving this region of the long arm of chromosome 6 occur frequently in human malignant melanoma , and there are anecdotal reports of myb gene rearrangements in this cancer . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
103,
108
]
} | {
"id": "C0026900",
"name": "myb",
"pos": [
165,
168
]
} |
rflp analysis was performed on several other types of human cancers , including carcinoma of the uterine cervix , neuroblastoma , hepatocellular carcinoma , pheochromocytoma , and stomach cancer to determine the chromosomal loci of putative tumor suppressor genes in each tumor . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
54,
59
]
} | {
"id": "C0079427",
"name": "tumor suppressor",
"pos": [
241,
257
]
} |
many retroviruses express gag-pol or gag-pro-pol polypeptides by coupling their translation from overlapping reading frames with -1 ribosomal frameshifts . | organism_has_gene | {
"id": "C0035366",
"name": "retroviruses",
"pos": [
5,
17
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
49,
52
]
} |
the autospecific t cell clones also responded to murine l cell transfectants expressing dr alpha dr1 beta as well as to transfectants expressing the mouse/human hybrid mhc molecule i-e alpha dr1 beta but not to the reciprocal combination dr alpha i-e beta , thus confirming the importance of the beta 1 domain to t cell recognition . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
155,
160
]
} | {
"id": "C1333247",
"name": "dr1",
"pos": [
191,
194
]
} |
cytogenetic and molecular genetic analyses of human intraspecific hela x fibroblast hybrids have provided evidence for the presence of a tumor-suppressor gene ( s ) on chromosome 11 of normal cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
46,
51
]
} | {
"id": "C0079427",
"name": "tumor-suppressor",
"pos": [
137,
153
]
} |
the effect of co ( ii ) ion on the reaction of hydrogen peroxide with dna was investigated by a dna sequencing technique using 32p-5'-end-labeled dna fragments obtained from human c-ha-ras-1 protooncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
174,
179
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
185,
188
]
} |
only primate gammag-globulins contained these antigenic determinants and in some cases the cryoglobulin appeared to show specificity for one human heavy chain subclass over the others . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
141,
146
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
147,
158
]
} |
a cdna encoding the carboxyl-terminal fragment of the human myeloperoxidase heavy chain was isolated and characterized . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
54,
59
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
76,
87
]
} |
in addition to the strong cross-reaction with purified light chains , human heavy chains reacted weakly with the antibody . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
70,
75
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
76,
88
]
} |
these studies provide evidence for the first time for a direct interaction between human f-va heavy chain and f-xa and ca++ and for the direct binding of f-xa to f-va in the absence of phospholipids or platelets and enhance our understanding of functional f-v domains . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
83,
88
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
94,
105
]
} |
recombinant human tumor necrosis factor alpha regulates c-myc expression in hl-60 cells at the level of transcription . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
12,
17
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
56,
61
]
} |
identification of p34 and p13 , human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+ . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
32,
37
]
} | {
"id": "C1707108",
"name": "cdc2",
"pos": [
104,
108
]
} |
peptide mapping of p34cdc2 , p36cdc28 , and human p34 revealed complete conservation of four tryptophan residues in the three proteins . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C1415345",
"name": "p34",
"pos": [
50,
53
]
} |
we describe malignant transformation of cultured rat intestinal epithelial cells ( iec-18 ) by transfection with the activated human h-ras gene cloned from the ej bladder carcinoma . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
127,
132
]
} | {
"id": "C0079471",
"name": "h-ras gene",
"pos": [
133,
143
]
} |
using transient assays of chloramphenicol acetyltransferase expression in cv-1 cells , we have localized the human c-ha-ras oncogene promoter to a 550 bp fragment located about 1 kb upstream from the ras coding sequence . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
109,
114
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
200,
203
]
} |
in addition to this , human and murine il-1 beta genes show extensive sequence homology within the intervening sequences . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
22,
27
]
} | {
"id": "C1708431",
"name": "il-1 beta genes",
"pos": [
39,
54
]
} |
nude mice bearing the human choriocarcinoma bewo , which is ssea-1 positive , were injected using a mixture of [ 131i ] anti-ssea-1 and [ 125i ] mopc 104e , an unselected myeloma protein of the same heavy-chain isotype . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
22,
27
]
} | {
"id": "C1420192",
"name": "heavy-chain",
"pos": [
199,
210
]
} |
signals provided in vivo by human ril-2 and con a can switch hapten-specific tolerance from unresponsiveness to responsiveness in the south african clawed toad . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
28,
33
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
34,
37
]
} |
a cloned genomic dna fragment derived from a retroviral site has been used to define a novel locus , pol-5 , that is tightly linked to both h-30 and ril-1 as shown by analysis of the b6.c-h-30c congenic mouse strain . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
45,
55
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
101,
104
]
} |
since corticosteroids can inhibit clonal expansion of thymus-derived ( t ) immunocytes by effecting lymphokines in mammals , we tested recombinant dna-produced human interleukin-1 ( ril-1 ) and interleukin-2 ( ril-2 ) , and the lectin concanavalin a in vivo . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
160,
165
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
210,
213
]
} |
finally , the calcyclin gene has been localized to the long arm of human chromosome 1 , near the ski oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
67,
72
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
101,
109
]
} |
a dna restriction fragment length polymorphism has been found immediately 3 ' to the human apob gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
85,
90
]
} | {
"id": "C1412471",
"name": "apob gene",
"pos": [
91,
100
]
} |
the human cell surface antigen 4f2 is a disulfide-linked heterodimer consisting of a glycosylated heavy chain and a nonglycosylated light chain . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1420192",
"name": "4f2",
"pos": [
31,
34
]
} |
human sperm samples ( n = 211 ) were prepared for in-vitro fertilization ( ivf ) and embryo transfer by a self-migration procedure in earle 's medium containing highly purified hyaluronic acid ( hya ) ( mw 3,000,000 ) included to increase the viscosity of the medium . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
75,
78
]
} |
evidence derived from the complete amino acid sequences of the variable regions of both the heavy and light chains of two members ( bor and kas ) of the wa idiotypic family of human rheumatoid factors suggests that not only are the light chains of these molecules derived from possibly one variable region gene segment , but the heavy chain variable regions are all derived from the vhi subgroup of human v region genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
176,
181
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
329,
340
]
} |
from a comparison with the human capacity for tactile discrimination of the steps , it was concluded that ras , through their discharge rates , provide primarily `` '' intensive '' '' information about the sharpness of shapes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
27,
32
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
106,
109
]
} |
when the same step stimuli were applied to the human fingerpad , the capacities of humans to discriminate differences in step shape were found to correlate with the discriminability of sas , as opposed to the considerably poorer discriminability of ras . | organism_has_gene | {
"id": "C0086418",
"name": "humans",
"pos": [
83,
89
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
249,
252
]
} |
amplification of the human protooncogene c-erbb-2 was found in 12 of 36 human breast tumours and was associated with increased levels of expression of the c-erbb-2 protein , measured both by immunohistological staining and by western blotting . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
21,
26
]
} | {
"id": "C0243036",
"name": "erbb",
"pos": [
157,
161
]
} |
our findings sustain the belief that n-myc is an authentic proto-oncogene , lend further credibility to the role of n-myc in the genesis of human tumors , and establish a convenient assay that can be used to explore further the properties of both n-myc and c-myc . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
140,
145
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
257,
262
]
} |
using dna transfection analysis on nih 3t3 cells , activated human oncogenes have been isolated from a variety of fresh solid tumours . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
61,
66
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
67,
76
]
} |
sequence of a cdna coding for human glutathione peroxidase confirms tga encodes active site selenocysteine . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
30,
35
]
} | {
"id": "C2699751",
"name": "tga",
"pos": [
68,
71
]
} |
the human homeo box-containing cluster of genes at chromosome region 17q21 is the human cognate of the mouse homeo box-containing gene cluster on mouse chromosome 11 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0017347",
"name": "homeo box",
"pos": [
109,
118
]
} |
by screening both human genomic and cdna libraries using v-yes dna as a probe , we obtained dna clones of the c-yes gene , the pseudogene of c-yes , c-fgr gene and c-src gene and two novel yes-related genes , fyn and lyn . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C1708019",
"name": "c-fgr gene",
"pos": [
149,
159
]
} |
by screening both human genomic and cdna libraries using v-yes dna as a probe , we obtained dna clones of the c-yes gene , the pseudogene of c-yes , c-fgr gene and c-src gene and two novel yes-related genes , fyn and lyn . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C0812303",
"name": "fyn",
"pos": [
209,
212
]
} |
by screening both human genomic and cdna libraries using v-yes dna as a probe , we obtained dna clones of the c-yes gene , the pseudogene of c-yes , c-fgr gene and c-src gene and two novel yes-related genes , fyn and lyn . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C0812307",
"name": "lyn",
"pos": [
217,
220
]
} |
we have identified a novel transforming gene , hst , from a human stomach cancer , and the results of our studies on hst are reviewed . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
60,
65
]
} | {
"id": "C0919466",
"name": "hst",
"pos": [
117,
120
]
} |
primary human hepatocellular carcinomas ( hcc ) were surveyed for oncogenes by transformation assays using nih3t3 cells and the calcium phosphate coprecipitation method . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
66,
75
]
} |
analysis of nucleotide sequences of the exons of human n-ras oncogenes cloned from the tumors revealed a single point mutation of the codon encoding the 13th amino acid of exon 1 from guanine to cytosine in all 3 cases of mds . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
49,
54
]
} | {
"id": "C0027260",
"name": "n-ras oncogenes",
"pos": [
55,
70
]
} |
using one of those anti-ras p21 monoclonal antibodies , rask-3 the expression of p21 in human stomach cancer and thyroid cancer was studied by means of immuno-histochemistry . ras p21 was more dominantly expressed in cancer cells than in normal epithelial cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
88,
93
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
176,
179
]
} |
apart from the retroviral gag , pol and env the hiv genome contains the f ( 3 ' orf ) gene which encodes a polypeptide of 206 amino acids which is myristylated at the n-terminal and whose function is unknown . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
15,
25
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
107,
110
]
} |
apart from the retroviral gag , pol and env the hiv genome contains the f ( 3 ' orf ) gene which encodes a polypeptide of 206 amino acids which is myristylated at the n-terminal and whose function is unknown . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
15,
25
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
40,
43
]
} |
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