text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
four separate features could be distinguished in fe-dnaase-1 digestions of human lymphoblast nuclei : a di-nucleosomal ( 2n ) repeat , a mono-nucleosomal ( 1n ) repeat , a component of `` '' random '' '' dna , and triple splitting of major peaks . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
75,
80
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
104,
106
]
} |
the synthesis of retroviral polyproteins that are the translational products of the genome-size mrna is initiated in the upstream gag gene . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
17,
27
]
} | {
"id": "C0017346",
"name": "gag gene",
"pos": [
130,
138
]
} |
the deduced amino acid sequence of the hst protein is 43 % , 38 % , and 40 % homologous , respectively , to human basic fibroblast growth factor , human acidic fibroblast growth factor , and mouse int-2 protein in selected regions . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
108,
113
]
} | {
"id": "C1708016",
"name": "int-2",
"pos": [
197,
202
]
} |
the chicken c-erba and the human c-erba-beta genes encode high-affinity receptors for thyroid hormone , and here it is shown that the erba-t protein binds specifically to 3,5,3'-triiodo-l-thyronine with a dissociation constant of 3.8 +/- 0.2 x 10 ( -10 ) m . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
27,
32
]
} | {
"id": "C0242987",
"name": "erba",
"pos": [
134,
138
]
} |
reactivities of fe3+ chelates of aminopolycarboxylic acids with dna were investigated by the dna-sequencing technique using 32p 5'-end-labeled dna fragments obtained from the human c-ha-ras-1 protooncogene , and the reaction mechanism was studied by electron spin resonance spectroscopy . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
175,
180
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
186,
189
]
} |
malignant undifferentiated sarcomas were induced in 11 of 15 ( 73.3 % ) newborn syrian hamsters by s.c. inoculation of a recombinant dna ( pbk/c-rasa ) containing bk virus ( bkv ) early region gene and the activated human c-harvey-ras ( c-ha-ras ) oncogene derived from t24 bladder carcinoma . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
216,
221
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
242,
245
]
} |
malignant undifferentiated sarcomas were induced in 11 of 15 ( 73.3 % ) newborn syrian hamsters by s.c. inoculation of a recombinant dna ( pbk/c-rasa ) containing bk virus ( bkv ) early region gene and the activated human c-harvey-ras ( c-ha-ras ) oncogene derived from t24 bladder carcinoma . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
216,
221
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
248,
256
]
} |
in an epidemiological study , we evaluated the human amino-terminal portion ( ir-hnt ) of pro-opiomelanocortin ( pomc ) as a biomarker for lung cancer by measuring it by radioimmunoassay in the plasma of 180 patients with various histological types of pulmonary carcinoma . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
47,
52
]
} | {
"id": "C1419758",
"name": "hnt",
"pos": [
81,
84
]
} |
to define the extent of involvement of ras oncogenes in human gastric cancers , we surveyed for the presence of ras oncogenes , activated by either point mutations within their coding sequences or overexpression of ras protein p21 , by the combined use of several analytic techniques . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
56,
61
]
} | {
"id": "C0034678",
"name": "ras oncogenes",
"pos": [
112,
125
]
} |
human neoplastic b cells express more than two isotypes of immunoglobulins without deletion of heavy-chain constant-region genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1420192",
"name": "heavy-chain",
"pos": [
95,
106
]
} |
in addition , a minimum of eight regions of homology to alu-type repetitive elements were detected in this human dna fragment , one of which was located 53 bp upstream from a trna ( gaaphe ) gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
107,
112
]
} | {
"id": "C1334094",
"name": "53 bp",
"pos": [
153,
158
]
} |
expression of ras p21 in human gastric cancers , benign lesions ( i.e . dysplasia , intestinal metaplasia and hyperplastic polyps ) and normal tissues was immunohistochemically evaluated by the avidin-biotin complex ( abc ) immunoperoxidase method with anti-ras p21 monoclonal antibody ( rp-28 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
25,
30
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
258,
261
]
} |
in human liver , ae1 stained mallory bodies and the bile duct epithelium intensely , but did not stain normal hepatocytes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
3,
8
]
} | {
"id": "C1420193",
"name": "ae1",
"pos": [
17,
20
]
} |
the human progesterone receptor gene was mapped by in situ hybridization using two cdna probes corresponding to the 5 ' and 3 ' part of the coding sequence . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1366500",
"name": "progesterone receptor gene",
"pos": [
10,
36
]
} |
reaction of n-nitrosomethyl ( acetoxymethyl ) amine in vitro in the presence of esterase with a plasmid containing the human c-ha-ras-1 gene has been shown to generate a transforming oncogene when the methylated dna is transfected into nih 3t3 cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
119,
124
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
183,
191
]
} |
human recombinant interleukins 1 alpha and 1 beta ( ril-1 alpha and -1 beta ) both induced monophasic peripheral neutrophilia and lymphopenia in lewis rats 1.5 hr after i.v . injection . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
52,
55
]
} |
we have previously described a human keratinocyte line , nm1 , which had been carried for more than 400 doublings , was trisomic for chromosome 8 , and appeared to make a number of structural proteins characteristic of keratinocytes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
31,
36
]
} | {
"id": "C1334885",
"name": "nm1",
"pos": [
57,
60
]
} |
intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
29,
34
]
} | {
"id": "C0376623",
"name": "multidrug-resistance gene",
"pos": [
90,
115
]
} |
we have found that normal human kidney , six of eight adenocarcinomas of the kidney , and four cell lines derived from kidney adenocarcinomas express high levels of mdr1 mrna . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
165,
169
]
} |
two criteria suggest that primary multidrug resistance in human adenocarcinomas of the kidney results , at least in part , from expression of the mdr1 gene : ( 1 ) mdr1 mrna levels are elevated in four unselected kidney adenocarcinoma cell lines that show a multidrug-resistant phenotype ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
58,
63
]
} | {
"id": "C1704939",
"name": "mdr1 gene",
"pos": [
146,
155
]
} |
two criteria suggest that primary multidrug resistance in human adenocarcinomas of the kidney results , at least in part , from expression of the mdr1 gene : ( 1 ) mdr1 mrna levels are elevated in four unselected kidney adenocarcinoma cell lines that show a multidrug-resistant phenotype ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
58,
63
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
164,
168
]
} |
we have cloned several prototypic members of the family of human endogenous retroviruslike elements having a histidine trna primer-binding site ( rtvl-h ) and have determined the nucleotide sequence of one of these clones ( rtvl-h2 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
59,
64
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
229,
231
]
} |
human brain ferritin is composed of two types of subunits -- about 70 % heavy chain ( mr , 22,000 ) and 30 % light chain ( mr , 19,500 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
72,
83
]
} |
the human b-cell line rj2.2.5 , derived by mutagenesis from a burkitt lymphoma cell line and selected for loss of hla class ii antigen expression , was infected with recombinant retroviruses containing either the harvey murine sarcoma virus oncogene v-ha-ras or the human neuroblastoma homolog nras . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0027260",
"name": "nras",
"pos": [
294,
298
]
} |
human monoclonal cryoglobulins , jir ( igg3 kappa ) , wat ( igg3 lambda ) , fji ( igm kappa ) , and human myeloma proteins , har ( iggl kappa ) and kob ( iga kappa ) were used for the present experiments . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C3273328",
"name": "har",
"pos": [
125,
128
]
} |
likewise , human fecal homogenates produced only about 10 % as much h2 and co2 during incubation with bran as with glucose or lactulose . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
11,
16
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
68,
70
]
} |
the comparison of human errors with the experimental results obtained in animals permitted formulation of several suppositions on the role of different cerebral structures in the genesis of emotional stress and the mechanisms of its effect on perceptive activity . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C1414672",
"name": "genesis",
"pos": [
179,
186
]
} |
a comparable procedure was utilized in the purification of the tsta from human tumors by using affinity chromatography on anti-human beta2-microglobulin antiserum coupled to a solid phase . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
73,
78
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
133,
138
]
} |
in this study support was obtained for the previous notion that the human lymphoma daudi does not produce beta2-microglobulin ( beta2m ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
68,
73
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
128,
133
]
} |
the mobility of the slower murine splenocyte surface heavy chain was identical to that of human mu-chain , but that of the second splenocyte heavy chain was significantly faster than that of human zota-chain , and similar to that of the heavy chain of toad igy . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
90,
95
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
237,
248
]
} |
selection seems to act in two ways : -- horizontally , in a multigene system such as the immunoglobulin classes ( c domains of the heavy chains ) , leading to interclass homologies which are particularly marked for all the cooh-terminal domains of h and l chains which have , in addition a fair degree of homology with human beta2 microglobulin ( about 30 % identities ) ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
319,
324
]
} | {
"id": "C1417683",
"name": "beta2",
"pos": [
325,
330
]
} |
the first component of complement , c1 , was isolated unactivated from human serum by repeated additions of di-isopropyl phosphorofluoridate during isolation . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
71,
76
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
108,
110
]
} |
human embryonic skin fibroblasts ( hsf ) incubated overnight with either human recombinant interleukin-1 alpha ( ril-1 alpha ) or interleukin-1 beta ( ril-1 beta ) released large amounts of prostaglandin e2 ( pge2 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
151,
154
]
} |
recent reports demonstrate that 40 % of human colon cancers and 20 % of acute leukemias contain ras mutations in the twelfth or thirteenth codon that can result in amino acid substitutions at these positions in the p21 products . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
40,
45
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
96,
99
]
} |
similarly , studies of ras mrna detected 40 % of human colon tumors with twelfth codon c-ki-ras mutant mrna . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
49,
54
]
} | {
"id": "C1537502",
"name": "ki-ras",
"pos": [
89,
95
]
} |
in this report the authors show that one of seven de novo human bladder cancers and four of seven colon cancers express a twelfth codon activated ras p21 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
58,
63
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
146,
149
]
} |
four multidrug-resistant variants of the human squamous lung cancer cell line sw-1573 with levels of doxorubicin resistance ranging from 10- to 2000-fold were characterized with respect to drug accumulation and efflux , subcellular drug distribution pattern , antioxidant defenses , and p-glycoprotein expression . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
41,
46
]
} | {
"id": "C0376622",
"name": "doxorubicin resistance",
"pos": [
101,
123
]
} |
human hela cell nuclei , isolated after whole-cell incubations , bound [ 125i ] t3 with high affinity ( kd = 78 +/- 8 pmol/l , mean +/- sem ) , which was displaceable by t3 analogues in the order triac [ ( 4- ( 4-hydroxy-3-iodophenoxy ) -3,5-di-iodophenyl ] acetic acid ) greater than t3 greater than t4 much greater than reverse t3 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
242,
244
]
} |
the use of donkey , pig , horse , sheep and human serum led to the migration of the 2-o-pivaloyl group in substrate 1 to the position 4- in the sugar molecule , followed by stepwise de-esterifications of both 1 and the newly formed methyl 4,6-di-o-pivaloyl-alpha-d-glucopyranoside ( 4 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
243,
245
]
} |
a novel human muscle factor related to but distinct from myod1 induces myogenic conversion in 10t1/2 fibroblasts . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C1417574",
"name": "myod1",
"pos": [
57,
62
]
} |
we have isolated the cdna encoding a novel human myogenic factor , myf-5 , by weak cross-hydridization to the mouse myod1 probe . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
43,
48
]
} | {
"id": "C1417574",
"name": "myod1",
"pos": [
116,
121
]
} |
nucleotide sequence analysis and the identification of the corresponding gene indicate that human myf-5 is a member of a small gene family which also contains the human homologue to myod1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
92,
97
]
} | {
"id": "C1417574",
"name": "myod1",
"pos": [
182,
187
]
} |
regulation of the human proto-oncogene myc apparently plays an important role in cellular proliferation and the genesis of diverse tumors . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C1414672",
"name": "genesis",
"pos": [
112,
119
]
} |
we examined the effects of recombinant human tumor necrosis factor ( rtnf ) , lymphotoxin ( rlt ) and interleukin 1 ( ril-1 ) on the induction of differentiation of m1 cells , compared with the effects of d-factor purified from the conditioned medium of mouse ehrlich ascites tumor cells and recombinant human granulocyte colony-stimulating factor ( rg-csf ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
39,
44
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
118,
121
]
} |
rtnf stimulated induction of differentiation of m1 cells by d-factor , rg-csf or ril-1 by two or three fold . | organism_has_gene | {
"id": "C0086418",
"name": "rtnf",
"pos": [
0,
4
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
81,
84
]
} |
addition of human ril-6 on u937 and hl-60 cells inhibited their proliferation and enhanced expression of hla class i ag . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
12,
17
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
18,
21
]
} |
mdr1 rna levels in human renal cell carcinomas : correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C0376622",
"name": "doxorubicin resistance",
"pos": [
102,
124
]
} |
we prepared retrovirus packaging cell lines containing gag-pol genes from spleen necrosis virus ( expressed from a cytomegalovirus promoter and the simian virus 40 ( sv40 ) polyadenylation sequences ) and , on a separate vector , either the env gene from spleen necrosis virus ( expressed from the rous sarcoma virus promoter and the sv40 polyadenylation sequences ) or the env gene from amphotropic murine leukemia virus ( expressed from a cytomegalovirus promoter and the sv40 polyadenylation sequences ) . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
12,
22
]
} | {
"id": "C0017346",
"name": "gag",
"pos": [
55,
58
]
} |
we prepared retrovirus packaging cell lines containing gag-pol genes from spleen necrosis virus ( expressed from a cytomegalovirus promoter and the simian virus 40 ( sv40 ) polyadenylation sequences ) and , on a separate vector , either the env gene from spleen necrosis virus ( expressed from the rous sarcoma virus promoter and the sv40 polyadenylation sequences ) or the env gene from amphotropic murine leukemia virus ( expressed from a cytomegalovirus promoter and the sv40 polyadenylation sequences ) . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
12,
22
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
479,
482
]
} |
we prepared retrovirus packaging cell lines containing gag-pol genes from spleen necrosis virus ( expressed from a cytomegalovirus promoter and the simian virus 40 ( sv40 ) polyadenylation sequences ) and , on a separate vector , either the env gene from spleen necrosis virus ( expressed from the rous sarcoma virus promoter and the sv40 polyadenylation sequences ) or the env gene from amphotropic murine leukemia virus ( expressed from a cytomegalovirus promoter and the sv40 polyadenylation sequences ) . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
12,
22
]
} | {
"id": "C0017343",
"name": "env gene",
"pos": [
374,
382
]
} |
using v-abl probes , we have identified and cloned a novel fes/fps-homologous human cdna , which we have designated fer ( pronounced `` '' fair '' '' ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
78,
83
]
} | {
"id": "C0812288",
"name": "fer",
"pos": [
116,
119
]
} |
the detailed mechanisms leading to transcriptional activation of the human myc oncogene in general as well as in certain tumor cells are poorly understood . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
69,
74
]
} | {
"id": "C0086661",
"name": "myc",
"pos": [
75,
78
]
} |
these results suggest that e1a proteins can lead to an imbalance of the regulation of the human myc gene , which might be a sufficient prerequisite for initiation and progression of transformation . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
90,
95
]
} | {
"id": "C0026902",
"name": "myc gene",
"pos": [
96,
104
]
} |
a rat brain cdna library has been constructed in a saccharomyces cerevisiae expression vector and used to isolate genes that can function in yeast to suppress the phenotypic effects of ras2val19 , a mutant form of the ras2 gene analogous to an oncogenic mutant of the human hras gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
268,
273
]
} | {
"id": "C0079471",
"name": "hras",
"pos": [
274,
278
]
} |
human basic fibroblast growth factor gene encodes four polypeptides : three initiate translation from non-aug codons . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1708015",
"name": "basic fibroblast growth factor gene",
"pos": [
6,
41
]
} |
retroviral gag gene-encoded core nucleic acid binding proteins contain either one or two sequences of the form cys-xaa2-cys-xaa4-his-xaa4-cys . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
0,
10
]
} | {
"id": "C0017346",
"name": "gag gene",
"pos": [
11,
19
]
} |
the retroviral protease-encoding region , pr , situated between the gag and pol genes , underwent gene duplication in the lineage now represented by simian retrovirus type 1 ; | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
4,
14
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
76,
79
]
} |
these t-cell clones also cross-reacted on dr4dw13 and drw14dw16 molecules and on a human/murine hybrid class ii dimer dr1 beta/i-e alpha . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
83,
88
]
} | {
"id": "C1333247",
"name": "dr1",
"pos": [
118,
121
]
} |
human colorectal carcinomas frequently express elevated levels of c-myc mrna in the absence of a gross genetic change at the c-myc locus . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
125,
130
]
} |
we have used chromosome-mediated gene transfer ( cmgt ) and whole cell fusion to derive human-mouse hybrid cells carrying reduced human chromosomes 11 , by selecting for expression of the transforming h-ras 1 oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
88,
93
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
203,
206
]
} |
we have used chromosome-mediated gene transfer ( cmgt ) and whole cell fusion to derive human-mouse hybrid cells carrying reduced human chromosomes 11 , by selecting for expression of the transforming h-ras 1 oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
88,
93
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
209,
217
]
} |
some reports dealt with the action , the induction of brms and its influences on the human oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
85,
90
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
91,
99
]
} |
separated tils were cultured by okt3 coated 96 well culture plate for about one week with 10 % human serum and 1,000u/ml of ril-2 supplemented rpmi-1640 medium , and then transferred to plain vessels . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
95,
100
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
124,
127
]
} |
human milk-fat globule membrane antigens ( mam-3 group ) in normal cycling endometrium and endometrial carcinomas -- an immunohistochemical study . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C2987159",
"name": "mam-3",
"pos": [
43,
48
]
} |
such cell lines provide a virus-free system for the high-capacity screening of compounds for the ability to interfere with hiv tat-mediated transactivation of gene expression . | organism_has_gene | {
"id": "C0019682",
"name": "hiv",
"pos": [
123,
126
]
} | {
"id": "C0017375",
"name": "tat",
"pos": [
127,
130
]
} |
in addition , we show that activated human thymocytes express the tnf-alpha gene and that the expression of this gene is inhibited by cyclosporin a and dexamethasone . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
37,
42
]
} | {
"id": "C1710304",
"name": "tnf-alpha gene",
"pos": [
66,
80
]
} |
pharmacological control of the human gastric histamine h2 receptor by famotidine : comparison with h1 , h2 and h3 receptor agonists and antagonists . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
31,
36
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
104,
106
]
} |
to determine if mouse class i alleles had the same transport requirements as the human class i glycoproteins , either mouse h-2dp or h-2kb class i genes were introduced into t2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
81,
86
]
} | {
"id": "C0017355",
"name": "class i genes",
"pos": [
139,
152
]
} |
we find that , as with ra induction , transfection of t2 cells with oncogenic human ha-ras results in cells which are permissive for hcmv infection and gene expression . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
78,
83
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
87,
90
]
} |
five monoclonal antibodies ( mabs ) coded respectively # 111 , 122 , 206 , 209 and 609 were produced against human recombinant interleukin-1 beta ( ril-1 beta , amino acids 117-269 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
109,
114
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
148,
151
]
} |
interestingly , this sequence is also present in one of the two sequences identified in retroviruses as frameshift signals for production of transframe polyproteins from the overlapping genes gag-pro or gag-pro-pol . | organism_has_gene | {
"id": "C0035366",
"name": "retroviruses",
"pos": [
88,
100
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
211,
214
]
} |
22k g showed kinetic and physical properties very similar to those of smg p21 , a g protein recently isolated from bovine brain and human platelet membranes , having the same effector domain as ras p21s . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
132,
137
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
194,
197
]
} |
to analyze the mechanism of neoplastic transformation of rodent diploid cells by ras and myc oncogenes , human ej c-ha-ras and mouse c-myc second and third exons promoted by sv40 promoter were connected to psv2neo and psv2gpt , respectively . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
105,
110
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
119,
122
]
} |
we found that ( 1 ) the human dr beta probe hybridized to as many as 15 restriction fragments per rhesus dna sample , suggesting cross-hybridization at more than one locus of rhesus mhc class ii beta genes ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
24,
29
]
} | {
"id": "C0017349",
"name": "mhc class ii",
"pos": [
182,
194
]
} |
the physiologic role of cyclic adenosine monophosphate ( camp ) in the growth control of a spectrum of human cancer lines , including leukemic lines , and v-rash oncogene-transformed nih/3t3 cells is demonstrated by the use of site-selective camp analogs . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
103,
108
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
162,
170
]
} |
a novel human oncogene , designated vav , was generated by a genetic rearrangement during gene transfer assays . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
8,
13
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
14,
22
]
} |
we have constructed four different deletion mutants of a chimeric mouse-human igg3 anti- ( 4-hydroxy-3-nitrophenyl ) acetyl/ ( 5-iodo-4 hydroxy-3 nitrophenyl ) acetyl ( np/nip ) antibody lacking one or more of the four exons coding for the hinge region . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
72,
77
]
} | {
"id": "C1706141",
"name": "np",
"pos": [
169,
171
]
} |
southern blot analysis of the transfectant dna revealed the presence of a human n-ras oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
74,
79
]
} | {
"id": "C0027260",
"name": "n-ras oncogene",
"pos": [
80,
94
]
} |
expression of the human ets-2 oncogene in normal fetal tissues and in the brain of a fetus with trisomy 21 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C0812380",
"name": "ets",
"pos": [
24,
27
]
} |
chromosomal mapping of this clone using in situ hybridization to metaphase chromosomes and a panel of mouse x human somatic cell hybrids localized it to human chromosome 7p13-p15 in the region of the hox 1 locus . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
110,
115
]
} | {
"id": "C1415652",
"name": "hox 1",
"pos": [
200,
205
]
} |
six biopsies ( 4 of human fibrosarcomas , 1 of a b-cell lymphoma and 1 of a normal lymph node from a melanoma patient ) and 6 cell lines ( derived from 5 different human osteosarcomas and from 1 rhabdomyosarcoma ) , together with control cells , were examined for the expression of c-sis , c-fos and c-myc . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
20,
25
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
300,
305
]
} |
furthermore , a blocking study of tchmc-2 cytotoxicity using monoclonal antibodies against cd3 , cd8 and human mhc class i products showed that all of these antigen molecules were involved in the cytotoxicity of tchmc-2 clone against autologous hmc-2 cells , indicating mhc class i recognitive cytotoxicity . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
105,
110
]
} | {
"id": "C0017355",
"name": "mhc class i",
"pos": [
270,
281
]
} |
to evaluate the mutations further we have introduced a heterologous receptor , the human muscarinic receptor 1 ( hm1 ) , into the parental jurkat and mutant cell lines . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
83,
88
]
} | {
"id": "C1705014",
"name": "hm1",
"pos": [
113,
116
]
} |
a representative sample of 33 human oocytes and associated follicular fluids was obtained after a follicular growth period considered suitable for ivf . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
30,
35
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
147,
150
]
} |
human zygotes resulting from ivf were placed in two different culture systems to evaluate in-vitro development and to establish pregnancies in patients following embryo replacement . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
29,
32
]
} |
preincubation with heat-inactivated toxoplasma-antibody positive human serum did not increase activity of ril-2-activated nk cells against 51cr-labeled trophozoites . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
65,
70
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
106,
109
]
} |
we conclude that a single concentration of bsa can safely be used to supplement culture media in human ivf with several practical and economical benefits . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
97,
102
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
103,
106
]
} |
a high titer retroviral vector containing the cdna of human estrogen receptor ( her ) was generated and used to transfer the her gene into the rat 208f cell line . | organism_has_gene | {
"id": "C0086418",
"name": "her",
"pos": [
80,
83
]
} | {
"id": "C1414461",
"name": "her gene",
"pos": [
125,
133
]
} |
the expression of the integrated her gene in the infected rat cells was detected by northern blot analysis and by a functional assay in which the her gene product stimulated the production of a chloramphenicol acetyl transferase gene under the control of an estrogen-responsive element . | organism_has_gene | {
"id": "C0086418",
"name": "her",
"pos": [
33,
36
]
} | {
"id": "C1414461",
"name": "her gene",
"pos": [
146,
154
]
} |
( 2 ) the human homolog of int-2 , located on chromosome 11q13 , is frequently amplified in human primary tumors and is comprised in an amplification unit encompassing the hst gene , which is often coamplified ; | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
10,
15
]
} | {
"id": "C0919466",
"name": "hst",
"pos": [
172,
175
]
} |
using such bifunctional oligonucleotide probes in conjunction with polymerase chain reaction ( pcr ) amplification , we were able to detect single base substitutions in a target segment of the human h-ras protooncogene employing either functionality . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
193,
198
]
} | {
"id": "C1705572",
"name": "h-ras",
"pos": [
199,
204
]
} |
thus , the 15 kda molecules isolated from mouse f9-3 embryonal carcinoma cells appeared to share some common antigenic determinants with human tgf-beta 1 molecule . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
137,
142
]
} | {
"id": "C1366557",
"name": "tgf-beta 1",
"pos": [
143,
153
]
} |
using in vitro assays , we show that nuclear proteins related to the sp1 and gt-1 factors bind to a caccc box sequence in the human beta-globin enhancer , adjacent to binding sites for the erythroid-specific factor nfe1 and the ubiquitous factor cp1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
126,
131
]
} | {
"id": "C1333663",
"name": "nfe1",
"pos": [
215,
219
]
} |
human arf cdna clones were obtained from a human cdna library by cross-species hybridization with bovine arf1 , and the nucleotide and deduced amino acid sequences were determined . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1412504",
"name": "arf1",
"pos": [
105,
109
]
} |
however , the human thymidine kinase gene , which is present at the same chromosomal location as these two oncogenes ( 17q21-22 ) , was amplified in only tw tumours . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
14,
19
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
107,
116
]
} |
migration inhibitory effect of cell-free supernatants from tuberculin-stimulated cultures of human mononuclear leukocytes demonstrated by two-step mif agarose assay . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
93,
98
]
} | {
"id": "C3538735",
"name": "mif",
"pos": [
147,
150
]
} |
human cdnas rap1 and rap2 homologous to the drosophila gene dras3 encode proteins closely related to ras in the 'effector ' region . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
101,
104
]
} |
when bacterially made human normal or oncogenic t24 ras protein is added to 32p-labeled nrk cell membranes in the presence of guanosine 5'- [ gamma-thio ] triphosphate , normal ras protein increases by 3-fold the formation of inositol trisphosphate , whereas t24 ras protein has no significant effect . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
22,
27
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
263,
266
]
} |
the three-dimensional structures of the carboxyl-terminal regions of the p21 protein products of the human harvey ( ha ) , kirsten ( kia and kib ) , and neuroblastoma ( n ) ras oncogenes and various mutants have been determined by using conformational energy analysis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
101,
106
]
} | {
"id": "C0027260",
"name": "n",
"pos": [
260,
261
]
} |
the human ribosomal rna promoter contains two distinct control elements ( uce and core ) both of which are recognized by the sequence-specific dna binding protein ubf1 , which has now been purified to apparent homogeneity . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1421307",
"name": "ubf1",
"pos": [
163,
167
]
} |
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