text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the effects of human tgf beta 1 and ptgf beta 2 were compared with those of ptgf beta 1 on basal and egf-stimulated [ 3h ] thymidine incorporation . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
15,
20
]
} | {
"id": "C1366557",
"name": "tgf beta 1",
"pos": [
77,
87
]
} |
thus , the two mutants generated in vitro have defects at two different genetic loci encoding specific regulatory factors necessary for human class ii gene expression . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
136,
141
]
} | {
"id": "C0017349",
"name": "class ii gene",
"pos": [
142,
155
]
} |
these findings suggest that continued expression of hbsag or the presence of hepatitis b virus dna/rna in a given human hepatocellular carcinoma cell id not necessary for enhanced expression of ras or c-myc proteins . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
114,
119
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
194,
197
]
} |
the human lfa-3 gene is located at the same chromosome band as the gene for its receptor cd2 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1704877",
"name": "lfa-3 gene",
"pos": [
10,
20
]
} |
identification and characterization of transcriptional regulatory regions associated with expression of the human apolipoprotein e gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
108,
113
]
} | {
"id": "C1412481",
"name": "apolipoprotein e gene",
"pos": [
114,
135
]
} |
multiple cis-acting regulatory elements have been mapped within a 1-kilobase fragment spanning nucleotides -651 through +356 of the human apolipoprotein e gene using a transient expression system based on the chloramphenicol acetyltransferase gene as well as dnase i footprinting techniques . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
132,
137
]
} | {
"id": "C1412481",
"name": "apolipoprotein e",
"pos": [
138,
154
]
} |
we have previously shown that recombinant murine interferon-gamma , rifn-gamma , and recombinant human interleukin-1 alpha , ril-1 alpha , induce differentiation of murine pre-b-like cell line 70z/3 , a finding associated with stimulation of na+/h+ exchange across the plasma membrane . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
97,
102
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
125,
128
]
} |
retroviral gag gene amber codon suppression is caused by an intrinsic cis-acting component of the viral mrna . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
0,
10
]
} | {
"id": "C0017346",
"name": "gag gene",
"pos": [
11,
19
]
} |
a mutant ok10 virus in which the native frameshift of retroviruses between gag and pol was deleted expressed a shortened p200 ( delta p200 ) . | organism_has_gene | {
"id": "C0035366",
"name": "retroviruses",
"pos": [
54,
66
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
83,
86
]
} |
inhibition of human immunodeficiency virus by using an oligonucleoside methylphosphonate targeted to the tat-3 gene . | organism_has_gene | {
"id": "C0019682",
"name": "human immunodeficiency virus",
"pos": [
14,
42
]
} | {
"id": "C0017375",
"name": "tat",
"pos": [
105,
108
]
} |
however , more than 65000 independent genomic transfectants ( using wild-type human dna ) did not contain the functional at gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
78,
83
]
} | {
"id": "C1705846",
"name": "at gene",
"pos": [
121,
128
]
} |
dnas from human pancreatic adenocarcinomas were analyzed for the presence of mutations in codons 12 , 13 and 61 of the nras , kras and hras gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
10,
15
]
} | {
"id": "C0027260",
"name": "nras",
"pos": [
119,
123
]
} |
dnas from human pancreatic adenocarcinomas were analyzed for the presence of mutations in codons 12 , 13 and 61 of the nras , kras and hras gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
10,
15
]
} | {
"id": "C0079471",
"name": "hras gene",
"pos": [
135,
144
]
} |
using a fragment of the human mdr1 cdna we found high expression of a 5 kb mrna species which was not detectable in the sensitive parental ccrf-cem cell line . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
24,
29
]
} | {
"id": "C0376622",
"name": "mdr1",
"pos": [
30,
34
]
} |
the human igf-ii gene is situated on chromosome 11 , very close to the insulin gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1334091",
"name": "igf-ii gene",
"pos": [
10,
21
]
} |
in order to study the relationship between tumor transplantability to the nude mouse and abnormality of the myc family genes ( c-myc , n-myc , l-myc ) in human primary lung cancers , 32 various lung cancers were analyzed for abnormality of the myc family genes by southern blot hybridization , and were transplanted s.c. into nude mice . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
154,
159
]
} | {
"id": "C0026902",
"name": "myc family genes",
"pos": [
244,
260
]
} |
the v-mil oncogene , an avian homolog of the mouse v-mht and human c-raf oncogenes , previously thought to be non-transforming in the absence of a co-operating oncogene , transforms ef43 cells , allowing them to grow in an anchorage-independent manner , form tumors in nude mice and abolishes their ability to repopulate the cleared mammary fat pad . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
61,
66
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
160,
168
]
} |
3t3 cells transformed with human c-ras oncogenes ( ha-ras , ki-ras , n-ras ) or with src , an oncogene coding for a protein kinase , have lost sensitivity to growth control by pt , even though substrates for pt can still be adp-ribosylated in vivo . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
27,
32
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
71,
74
]
} |
3t3 cells transformed with human c-ras oncogenes ( ha-ras , ki-ras , n-ras ) or with src , an oncogene coding for a protein kinase , have lost sensitivity to growth control by pt , even though substrates for pt can still be adp-ribosylated in vivo . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
27,
32
]
} | {
"id": "C1537502",
"name": "ki-ras",
"pos": [
60,
66
]
} |
3t3 cells transformed with human c-ras oncogenes ( ha-ras , ki-ras , n-ras ) or with src , an oncogene coding for a protein kinase , have lost sensitivity to growth control by pt , even though substrates for pt can still be adp-ribosylated in vivo . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
27,
32
]
} | {
"id": "C0809246",
"name": "n-ras",
"pos": [
69,
74
]
} |
3t3 cells transformed with human c-ras oncogenes ( ha-ras , ki-ras , n-ras ) or with src , an oncogene coding for a protein kinase , have lost sensitivity to growth control by pt , even though substrates for pt can still be adp-ribosylated in vivo . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
27,
32
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
94,
102
]
} |
the dimeric structure of hutsp , together with its extensive sequence homologies with the murine t cell specific proteinase , mtsp-1 , suggests phylogenetic conservation of this serine proteinase family . | organism_has_gene | {
"id": "C0086418",
"name": "hutsp",
"pos": [
25,
30
]
} | {
"id": "C1704882",
"name": "mtsp-1",
"pos": [
126,
132
]
} |
these results indicate that human platelet membranes contain at least two low-molecular-mass g-proteins distinct from ras p21 , in addition to the heterotrimeric g-proteins , the alpha-subunits of which possess molecular mass values of about 40 kda . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
28,
33
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
118,
121
]
} |
assignment of the human hap retinoic acid receptor rar beta gene to the p24 band of chromosome 3 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
18,
23
]
} | {
"id": "C1335591",
"name": "retinoic acid receptor",
"pos": [
28,
50
]
} |
we have determined the phenotype of ebv-carrying cells in human blood by establishing spontaneous lcls from populations selected according to three b cell markers , b1 , b2 , and 35.1c5 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
58,
63
]
} | {
"id": "C1705575",
"name": "1c5",
"pos": [
182,
185
]
} |
these results indicate human ril-2 induces functional and morphological changes in swine peripheral blood lymphocytes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
23,
28
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
29,
32
]
} |
the human cd3 epsilon gene was located in the region immediately downstream of the cd3 delta and gamma genes using synthetic oligonucleotide probes and the localization of this gene confirmed by dna sequencing . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1705090",
"name": "cd3 epsilon gene",
"pos": [
10,
26
]
} |
the southern dna hybridization technique was used to determine the organization of human immunoglobulin heavy-chain-variable region ( vh ) gene families and the extent of polymorphism within these families . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
83,
88
]
} | {
"id": "C1420192",
"name": "heavy-chain",
"pos": [
104,
115
]
} |
using human platelets isolated from their plasma , we showed that 15-hydroperoxyu-eicosatetraenoic acid ( 15-hpete ) inhibits platelet aggregation induced either by arachidonic acid or prostaglandin h2 analog . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
6,
11
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
199,
201
]
} |
however , we have now shown that the chemokinetic and aggregating activities released from rat and human pmns exposed to ionophore a23187 ( ref . 5 ) are not due to the release of mono-hetes but to that of 5 , 12-di-hete ( leukotriene b ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
99,
104
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
213,
215
]
} |
comparison of this primary structure and the deduced amino acid sequence with the haemagglutinin gene and protein of strains belonging to the same ( h3 ) subtype and to different subtypes , of both human ( h2 ) and avian ( hav1 ) origin , documents further at the molecular level the two independent modes of antigenic variation of the virus -- drift and shift . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
198,
203
]
} | {
"id": "C0919509",
"name": "h2",
"pos": [
206,
208
]
} |
epstein-barr virus-transformed human precursor b cell lines : altered growth phenotype of lines with germ-line or rearranged but nonexpressed heavy chain genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
31,
36
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
142,
153
]
} |
[ developmental arrest of fertilized human oocytes in the pronuclear stage after in vitro fertilization ( ivf ) ] . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
37,
42
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
106,
109
]
} |
we have isolated a human genomic dna ( designated human frt ) cross-hybridizing with the v-ros oncogene of ur2 sarcoma virus . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
19,
24
]
} | {
"id": "C1705150",
"name": "frt",
"pos": [
56,
59
]
} |
the complete amino acid sequence of human type beta 2 transforming growth factor ( htgf-beta 2 ) was determined by automated edman degradation of s-pyridylethylated htgf-beta 2 and selected fragments . | organism_has_gene | {
"id": "C0086418",
"name": "htgf-beta 2",
"pos": [
83,
94
]
} | {
"id": "C1336621",
"name": "htgf-beta 2",
"pos": [
165,
176
]
} |
cleavage of htgf-beta 2 by enzymatic and chemical techniques established all the fragments in an unambiguous sequence . | organism_has_gene | {
"id": "C0086418",
"name": "htgf-beta 2",
"pos": [
12,
23
]
} | {
"id": "C1336621",
"name": "htgf-beta 2",
"pos": [
12,
23
]
} |
each htgf-beta 2 subunit is a single-chain polypeptide of 112 residues , with a calculated molecular weight of 12,720 . | organism_has_gene | {
"id": "C0086418",
"name": "htgf-beta 2",
"pos": [
5,
16
]
} | {
"id": "C1336621",
"name": "htgf-beta 2",
"pos": [
5,
16
]
} |
we report here that antibodies capable of inhibiting human lymphocyte binding to one or more hev types recognize a common 85-95-kd lymphocyte surface glycoprotein antigen , defined by the non-blocking monoclonal antibody , hermes-1 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
53,
58
]
} | {
"id": "C1426009",
"name": "hermes",
"pos": [
223,
229
]
} |
we have investigated the synergistic effects of phorbol ester and calcium ionophore on human t lymphocyte proliferation and the expression of the proliferation-related genes , c-myc , c-fos , interleukin 2 receptors ( il-2r ) and interleukin 2 ( il-2 ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
87,
92
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
176,
181
]
} |
only mus species closely related to laboratory mice carried these retroviral sequences , and the different subclasses of viral env genes tended to be restricted to specific taxonomic groups . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
66,
76
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
127,
130
]
} |
to define the role of cellular oncogenes in human cancers , we studied the prevalence of mutational activation of ras oncogenes in untreated non-small-cell lung cancer . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C0034678",
"name": "ras oncogenes",
"pos": [
114,
127
]
} |
in many retroviruses the 5 ' end of the pol gene codes for a protease vital for the processing of the gag polyprotein into the separate core proteins . | organism_has_gene | {
"id": "C0035366",
"name": "retroviruses",
"pos": [
8,
20
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
106,
109
]
} |
rflps associated with mdr2 , a member of the human multidrug resistance gene family mapped to chromosome 7 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
45,
50
]
} | {
"id": "C0376623",
"name": "multidrug resistance gene",
"pos": [
51,
76
]
} |
we analyzed nih 3t3 cells transfected with human h- , k- and n-ras oncogenes for their glycolipid composition and expression of cell surface gangliosides . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
43,
48
]
} | {
"id": "C0027260",
"name": "n-ras oncogenes",
"pos": [
61,
76
]
} |
allelic variation in the dr subregion of the human major histocompatibility complex has been analyzed by nucleic acid sequencing of cdna clones obtained from cell lines homozygous by consanguinity for all the common serological types dr1-9 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
45,
50
]
} | {
"id": "C1333247",
"name": "dr1",
"pos": [
234,
237
]
} |
by using hybridization to specific probes as well as a method based on the properties of rnase h , we found that the human igf-ii gene has at least three exons that encode alternative 5 ' untranslated regions and that are expressed in a tissue-specific manner . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
117,
122
]
} | {
"id": "C1334091",
"name": "igf-ii gene",
"pos": [
123,
134
]
} |
although strongly correlated with this specific human neoplasm , and implicated as an oncogene by analogy to the gene product of the abelson murine leukemia virus , the p210 gene had not been tested directly for oncogenic potential in hematopoietic cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
86,
94
]
} |
a complementary dna clone derived from rat brain messenger rna has been isolated on the basis of homology to the human thyroid hormone receptor gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
113,
118
]
} | {
"id": "C0919499",
"name": "thyroid hormone receptor gene",
"pos": [
119,
148
]
} |
we undertook an immunohistochemical analysis of human bronchopulmonary epithelial neoplasms and pleural mesotheliomas using a monoclonal antibody which recognizes ras oncogene products ( p21ras ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
48,
53
]
} | {
"id": "C0034678",
"name": "ras oncogene",
"pos": [
163,
175
]
} |
an allosteric model is presented that provides a simple explanation for the low population of triply ligated species , relative to the other species , in the oxygenation of human hemoglobin tetramers as found in high-concentration studies [ gill , s. j. , di cera , e. , doyle , m. l. , bishop , g. a. , & robert , c. h. ( 1987 ) biochemistry ( preceding paper in this issue ) ] . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
173,
178
]
} | {
"id": "C3538902",
"name": "di",
"pos": [
350,
352
]
} |
using the human liver cancer dna transfected nih/3t3 cell line , the human n-ras oncogene and the over expression of the oncoprotein p21ras was demonstrated , balb/c mice were immunized . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
10,
15
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
136,
139
]
} |
a human gastric signet ring cancer cell line ( mz-sto-1 ) was established in tissue culture from the ascites fluid of a 54-year-old patient . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
2,
7
]
} | {
"id": "C2698423",
"name": "sto",
"pos": [
50,
53
]
} |
in this modified serum-free medium , which we have designated mcm+sr1 , diploid human fibroblasts grew for 21 days at the same rate as in the base medium , mcm , supplemented with 10 % fbs ( i.e. , 21 population doublings ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
80,
85
]
} | {
"id": "C1709402",
"name": "mcm",
"pos": [
156,
159
]
} |
the value of oocyte reinsemination in human in vitro fertilization ( ivf ) was evaluated in this study . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
38,
43
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
69,
72
]
} |
fertilization and cleavage rates were compared in 1024 heparin-exposed and nonexposed human oocytes recovered from 183 consecutive in vitro fertilization ( ivf ) cycles . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
86,
91
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
156,
159
]
} |
in human thyroid slices prelabeled with myo- [ 2-3h ] inositol , thyrotropin ( tsh , 3-30 mu/ml ) stimulated ip3 , ip2 and ip1 generation over a prolonged time course . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
3,
8
]
} | {
"id": "C2697645",
"name": "ip1",
"pos": [
123,
126
]
} |
the organization of these class ii genes has been studied by southern blot hybridization using genomic dna from inbred and recombinant rat strains digested with various restriction endonuclease and hybridized under stringent conditions with probes for mouse class ii and human class ii genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
271,
276
]
} | {
"id": "C0017349",
"name": "class ii genes",
"pos": [
277,
291
]
} |
we have regionally localized the two human tyrosine kinase proto-oncogenes , c-ros-1 and flt , by in situ hybridization . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
37,
42
]
} | {
"id": "C0812329",
"name": "tyrosine kinase proto-oncogenes",
"pos": [
43,
74
]
} |
we have regionally localized the two human tyrosine kinase proto-oncogenes , c-ros-1 and flt , by in situ hybridization . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
37,
42
]
} | {
"id": "C0812281",
"name": "c-ros-1",
"pos": [
77,
84
]
} |
these two domains of homology are also present in the human glucocorticoid receptor ( gr ) and the product of the avian erythroblastosis virus ( aev ) gene , v-erba , indicating that c-erba , the cellular counterpart of v-erba , belongs to a multigene family of transcriptional regulatory proteins which bind steroid-related ligands . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
54,
59
]
} | {
"id": "C0242987",
"name": "erba",
"pos": [
222,
226
]
} |
filtrates obtained from 28- and 120-h growth of the spherule-endospore phase were compared with each other and with coccidioidin by using negative , immunoglobulin m ( igm ) precipitin-positive , or complement fixation-positive pooled and single human sera followed by peroxidase-labeled anti-human iga , ige , igg , or igm ( heavy chain specific ) or peroxidase-labeled concanavalin a to detect the reaction . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
246,
251
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
326,
337
]
} |
from a comparison of a hbv integration site present in a particular hcc with the corresponding unoccupied site in the non-tumorous tissue of the same liver , we now report that hbv integration places the viral sequence next to a liver cell sequence which bears a striking resemblance to both an oncogene ( v-erb-a ) and the supposed dna-binding domain of the human glucocorticoid receptor and human oestrogen receptor genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
359,
364
]
} | {
"id": "C1414461",
"name": "oestrogen",
"pos": [
399,
408
]
} |
restriction enzyme analyses showed that the minimal size of the lca transforming dna is about 10 kilobase pairs and that its cleavage profiles are different from those of any one of the previously reported human transforming genes or retroviral oncogenes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
206,
211
]
} | {
"id": "C0029016",
"name": "oncogenes",
"pos": [
245,
254
]
} |
chronic myelogenous leukemia ( cml ) is a human disease associated with a consistent chromosomal translocation that results in sequences from the c-abl locus on chromosome 9 being fused to sequences in a breakpoint cluster region ( bcr ) on chromosome 22 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
42,
47
]
} | {
"id": "C1704928",
"name": "abl",
"pos": [
148,
151
]
} |
the effects of the vinca alkaloids on the rates of dna synthesis in the human pancreatic carcinoma line , mia pa ca-2 have been studied by a new technique for measuring cell kinetics and dna synthesis by flow cytometry and immunofluorescence . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
72,
77
]
} | {
"id": "C1417154",
"name": "mia",
"pos": [
106,
109
]
} |
platelet adherence to human artery subendothelium in blood from eight normal subjects , four patients with glanzmann 's thrombasthenia ( deficiency of platelet membrane glycoproteins iib and iiia : gpiib-iiia ) , two patients with bernard-soulier syndrome ( deficiency of platelet membrane glycoprotein ib : gpib ) and one patient with von willebrand 's disease ( vwd subtype iii . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
22,
27
]
} | {
"id": "C1710605",
"name": "vwd",
"pos": [
364,
367
]
} |
the human h-ras protooncogene was shown to be expressed in 16 of 22 invasive ductal carcinomas of the breast . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1705572",
"name": "h-ras",
"pos": [
10,
15
]
} |
the findings suggest that the human gamma to beta switch is controlled by a developmental clock-like mechanism , which appears to be associated with chromosome 11 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
30,
35
]
} | {
"id": "C1413503",
"name": "clock",
"pos": [
90,
95
]
} |
there is no orf in 412 which corresponds to retroviral env or orf3s of 17.6 and 297 . | organism_has_gene | {
"id": "C0035366",
"name": "retroviral",
"pos": [
44,
54
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
55,
58
]
} |
colony formation of all human lung cancer cell lines , pc-1 , 3 , 6 , 7 , 9 , 13 and 14 were suppressed by lymphocytes activated with 100 units/ml of human ril-2 for 72 hr . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
24,
29
]
} | {
"id": "C1335621",
"name": "ril",
"pos": [
156,
159
]
} |
alterations in norepinephrine content and beta adrenoceptor regulation in myocardium bordering aneurysm in human heart : their possible role in the genesis of ventricular tachycardia . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
107,
112
]
} | {
"id": "C1414672",
"name": "genesis",
"pos": [
148,
155
]
} |
the size of the apo-e mrna observed in the stable transfectants was identical to that found in the liver , indicating that the mouse l cells were capable of correctly processing the human apo-e gene transcripts . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
182,
187
]
} | {
"id": "C1412481",
"name": "apo-e gene",
"pos": [
188,
198
]
} |
two types of tgf-betas were tested for their effects on the expression of secreted proteins in mouse and human fibroblasts : tgf-beta from human platelets and a growth inhibitor ( gi/tgf-beta ) secreted by bsc-1 cells . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
105,
110
]
} | {
"id": "C1420091",
"name": "bsc",
"pos": [
206,
209
]
} |
a radioimmunoassay for human plasma retinol-binding protein ( rbp ) has been developed utilizing a double antibody precipitation technique . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
23,
28
]
} | {
"id": "C1419320",
"name": "plasma retinol-binding protein",
"pos": [
29,
59
]
} |
the relative decay of four human messenger rnas , gamma globin , delta globin , c-myc and h4 histone , were compared in a cell-free system . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
27,
32
]
} | {
"id": "C0086661",
"name": "c-myc",
"pos": [
80,
85
]
} |
analysis of these clones revealed that the retrovirus-related gene sequences are linked in the order ltr-gag-pol-env-ltr , a structure indicative of a complete provirus . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
43,
53
]
} | {
"id": "C0017360",
"name": "pol",
"pos": [
109,
112
]
} |
analysis of these clones revealed that the retrovirus-related gene sequences are linked in the order ltr-gag-pol-env-ltr , a structure indicative of a complete provirus . | organism_has_gene | {
"id": "C0035366",
"name": "retrovirus",
"pos": [
43,
53
]
} | {
"id": "C0017343",
"name": "env",
"pos": [
113,
116
]
} |
characterization of human c-fes/fps reveals a new transcription unit ( fur ) in the immediately upstream region of the proto-oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
20,
25
]
} | {
"id": "C1708010",
"name": "fps",
"pos": [
32,
35
]
} |
comparative southern blot and heteroduplex analysis of human and feline dna immediately upstream of the v-fes/fps homologous regions showed extensive but discontinuous homology over a 9 kbp dna stretch , which we have designated as fur . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
55,
60
]
} | {
"id": "C1708010",
"name": "fps",
"pos": [
110,
113
]
} |
comparison of the nh2-terminal sequences of human prekallikrein with those of the bovine prekallikrein and human bovine factors xia and xiia indicates a common origin of the heavy chain of kallikrein and factor xia , different from that of either factor xiia or other known amino acid sequences . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C1420192",
"name": "heavy chain",
"pos": [
174,
185
]
} |
nitrosyl complexes of the iron ( iii ) forms of myoglobin , human hemoglobin , glycera dibranchiata hemoglobins ( hbm and hbh ) , and model iron ( ii ) and iron ( iii ) synthetic porphyrins including octaethylporphyrin ( oep ) have been prepared . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
60,
65
]
} | {
"id": "C2697529",
"name": "hbh",
"pos": [
122,
125
]
} |
evidence by radioimmunoassay that mitogen-activated human blood mononuclear cells secrete significant amounts of light chain ig unassociated with heavy chain . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
52,
57
]
} | {
"id": "C1420192",
"name": "heavy",
"pos": [
146,
151
]
} |
using a normal human myc gene , we detected a weak growth stimulation at the colony formation stage and a low frequency of immortalization . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
15,
20
]
} | {
"id": "C0026902",
"name": "myc gene",
"pos": [
21,
29
]
} |
human gcs obtained from patients undergoing an ivf procedure and treated with cc , hmg , and hcg , lack camp responsiveness to hcg stimulation in vitro . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1419864",
"name": "ivf",
"pos": [
47,
50
]
} |
human thymocytes were fractionated to a low or high specific gravity fraction ( lf or hf ) by the bsa incontinuous density gradient method , and stimulated by lectin , lymphokine and mixed lymphocyte culture ( mlc ) in order to induce natural killer ( nk ) -like nonspecific killer ( activated lymphocyte killer , alk ) cell activity . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
0,
5
]
} | {
"id": "C1416933",
"name": "lf",
"pos": [
80,
82
]
} |
a cloned 850 bp cdna fragment corresponding to the 3'-coding part of human aldhi-mrna was used as a probe for the chromosomal assignment of the aldhi gene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
69,
74
]
} | {
"id": "C2827555",
"name": "aldhi",
"pos": [
144,
149
]
} |
southern blot analysis of human-rodent somatic cell hybrids indicates that the human aldhi gene resides on chromosome 12 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C2827555",
"name": "aldhi",
"pos": [
85,
90
]
} |
loss of the oncogene from human h-ras-1-transfected nih/3t3 cells grown in the presence of excess methionine . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
26,
31
]
} | {
"id": "C1705572",
"name": "h-ras",
"pos": [
32,
37
]
} |
serum from rabbits injected with igg prepared from the csf of patients with multiple sclerosis were rendered anti-idiotypic by adsorption on sequential columns of pooled human gamma-globulin , free light chains and free heavy chains . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
170,
175
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
220,
232
]
} |
examination of homologies between retroviral oncogenes and transforming sequences defined by transfection reveals that the human bladder carcinoma ( ej ) oncogene is homologous to the harvey sarcoma virus oncogene ( ras ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
123,
128
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
205,
213
]
} |
examination of homologies between retroviral oncogenes and transforming sequences defined by transfection reveals that the human bladder carcinoma ( ej ) oncogene is homologous to the harvey sarcoma virus oncogene ( ras ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
123,
128
]
} | {
"id": "C0079471",
"name": "harvey sarcoma virus oncogene",
"pos": [
184,
213
]
} |
examination of homologies between retroviral oncogenes and transforming sequences defined by transfection reveals that the human bladder carcinoma ( ej ) oncogene is homologous to the harvey sarcoma virus oncogene ( ras ) . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
123,
128
]
} | {
"id": "C0034678",
"name": "ras",
"pos": [
216,
219
]
} |
these results indicate that high levels of a gene product encoded by a normal human oncogene can induce tumorigenic transformation . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
78,
83
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
84,
92
]
} |
t24 human bladder carcinoma oncogene is an activated form of the normal human homologue of balb- and harvey-msv transforming genes . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C0029016",
"name": "transforming genes",
"pos": [
112,
130
]
} |
the normal human homologue of v-bas was found to be indistinguishable from the t24 oncogene by heteroduplex and restriction enzyme analysis . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
11,
16
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
83,
91
]
} |
southern blot analysis of t24-derived transformants showed that a single fragment of human dna specifically cosegregated with the malignant phenotype , suggesting that it contained the t24 oncogene . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
85,
90
]
} | {
"id": "C0029016",
"name": "oncogene",
"pos": [
189,
197
]
} |
monoclonal human b lymphoma cells were triggered in vitro to dna synthesis with f ( ab ' ) 2 fragments of rabbit igg antibodies specific for different human immunoglobulin ( ig ) light and heavy chains . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
11,
16
]
} | {
"id": "C1420192",
"name": "heavy chains",
"pos": [
189,
201
]
} |
dnas of 20 b- and t-lymphocyte neoplasms of human and mouse origin induced transformation of nih/3t3 cells with high efficiencies , indicating that these neoplasms contained activated transforming genes that were detectable by transfection . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
44,
49
]
} | {
"id": "C0029016",
"name": "transforming genes",
"pos": [
184,
202
]
} |
following treatment of a human b cell lymphoma with an anti-idiotype antibody , a subpopulation of tumor cells remained that had lost the tumor-specific heavy chain idiotypic determinant . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
25,
30
]
} | {
"id": "C1420192",
"name": "heavy",
"pos": [
153,
158
]
} |
the human apoai gene was expressed in e. coli by in-frame fusion to a modified beta-galactosidase gene present in plasmid pur291 . | organism_has_gene | {
"id": "C0086418",
"name": "human",
"pos": [
4,
9
]
} | {
"id": "C1412468",
"name": "apoai gene",
"pos": [
10,
20
]
} |
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