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in the presence of the 44d7 antigen isolated from human kidney , monoclonal antibody 44d7 could no longer inhibit na+-dependent ca2+ fluxes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 50, 55 ] }
{ "id": "C1420192", "name": "monoclonal antibody 44d7", "pos": [ 65, 89 ] }
these findings support the theory that in humans testosterone also plays a key role in the genesis of this sex difference .
organism_has_gene
{ "id": "C0086418", "name": "humans", "pos": [ 42, 48 ] }
{ "id": "C1414672", "name": "genesis", "pos": [ 91, 98 ] }
a rat monoclonal antibody ( mcab 21:9 ) reactive with the human invariant gamma-chain of class ii major histocompatibility complex ( mhc ) -encoded antigens was isolated and was shown to react with the carbohydrate-carrying , cooh-terminal part of the gamma-chain .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 58, 63 ] }
{ "id": "C1413237", "name": "gamma-chain of class ii", "pos": [ 74, 97 ] }
comparative effects of selected drug combinations on the growth of a human pancreatic carcinoma cell line ( mia paca-2 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 69, 74 ] }
{ "id": "C1417154", "name": "mia", "pos": [ 108, 111 ] }
the inhibitory effect of several drug combinations on the growth of the human pancreatic carcinoma cell line mia paca-2 was studied in relation to drug-scheduling interval in vitro .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 72, 77 ] }
{ "id": "C1417154", "name": "mia", "pos": [ 109, 112 ] }
to further elucidate the common and unique aspects of n-myc and c-myc gene structure and function in normal and transformed cells , we have determined the organization of human n-myc and the nucleotide sequence of its messenger product , and we report here that n-myc and c-myc have a similar intron/exon structure and that their protein products share regions of significant homology .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 171, 176 ] }
{ "id": "C0812287", "name": "n-myc", "pos": [ 262, 267 ] }
to further elucidate the common and unique aspects of n-myc and c-myc gene structure and function in normal and transformed cells , we have determined the organization of human n-myc and the nucleotide sequence of its messenger product , and we report here that n-myc and c-myc have a similar intron/exon structure and that their protein products share regions of significant homology .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 171, 176 ] }
{ "id": "C0086661", "name": "c-myc", "pos": [ 272, 277 ] }
we report here the identification of a human b-cell nuclear factor ( ignf-a ) that binds to dna sequences in the upstream regions of both the mouse heavy and kappa light-chain gene promoters and also to the mouse heavy-chain gene enhancer .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 39, 44 ] }
{ "id": "C1420192", "name": "heavy-chain", "pos": [ 213, 224 ] }
in this translocation , the human homologue of the abelson virus oncogene , c-abl , normally on chromosome 9 , is moved to chromosome 22 , while c-sis , the cellular homologue of the simian sarcoma virus oncogene , is moved from chromosome 22 to chromosome 9 ( refs 4-6 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 28, 33 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 204, 212 ] }
in this translocation , the human homologue of the abelson virus oncogene , c-abl , normally on chromosome 9 , is moved to chromosome 22 , while c-sis , the cellular homologue of the simian sarcoma virus oncogene , is moved from chromosome 22 to chromosome 9 ( refs 4-6 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 28, 33 ] }
{ "id": "C0751995", "name": "c-sis", "pos": [ 145, 150 ] }
in this translocation , the human homologue of the abelson virus oncogene , c-abl , normally on chromosome 9 , is moved to chromosome 22 , while c-sis , the cellular homologue of the simian sarcoma virus oncogene , is moved from chromosome 22 to chromosome 9 ( refs 4-6 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 28, 33 ] }
{ "id": "C0037207", "name": "simian sarcoma virus oncogene", "pos": [ 183, 212 ] }
peripheral benzodiazepine binding sites were characterized in human term placental membranes using [ 3h ] pk 11195 , which is a ligand specific for peripheral benzodiazepine binding sites .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 62, 67 ] }
{ "id": "C1823521", "name": "peripheral benzodiazepine binding sites", "pos": [ 148, 187 ] }
these data showed the association of rearrangement of 1q in endometrial cancer and/or redevelopment of tumor , and also suggest the possible participation of chromosome # 11 on which the human proto-oncogene c-ets was mapped .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 187, 192 ] }
{ "id": "C0812380", "name": "oncogene", "pos": [ 199, 207 ] }
using southern blot hybridization , we have analyzed the arrangement of 13 onc genes that are often associated with human malignancy , including c-myc .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 116, 121 ] }
{ "id": "C0086661", "name": "c-myc", "pos": [ 145, 150 ] }
in particular , as with 17.6 , another drosophila copia-like element , the second open reading frame of 297 was shown to be very similar in its entire organization to the retroviral pol gene and to consist of three enzymatic domains .
organism_has_gene
{ "id": "C0035366", "name": "retroviral", "pos": [ 171, 181 ] }
{ "id": "C0017360", "name": "pol gene", "pos": [ 182, 190 ] }
by contrast , no appreciable homology was found between the third open reading frame of 297 and the retroviral env gene .
organism_has_gene
{ "id": "C0035366", "name": "retroviral", "pos": [ 100, 110 ] }
{ "id": "C0017343", "name": "env gene", "pos": [ 111, 119 ] }
within the heavy chain of human high-mr kininogen are repetitive units strongly suggesting that the heavy chain of human kininogens has evolved from at least two ancestral units by a series of gene duplication and fusion events .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 26, 31 ] }
{ "id": "C1705846", "name": "at", "pos": [ 204, 206 ] }
the established human monoblast or early monocyte cell line , u937 , was evaluated for modulating influences of prostaglandin e2 ( pge2 ) on human gamma interferon ( huifn gamma ) induction of mhc class-ii ( ia ) antigens on u937 cells and the huifn gamma induction of responsiveness of u937 colony-forming cells ( cfc ) to inhibition by lactoferrin ( lf ) , transferrin ( tf ) , acidic isoferritins ( aif ) , and prostaglandin e ( pge ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 16, 21 ] }
{ "id": "C0017349", "name": "mhc class-ii", "pos": [ 193, 205 ] }
the two most sinister aspects of intraneoplastic diversity in human solid tumors are the genesis of clones with metastatic potential , and the existence of drug-resistant variants in primary cancers and their metastases .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 62, 67 ] }
{ "id": "C1414672", "name": "genesis", "pos": [ 89, 96 ] }
we deduced a composite pol protein sequence for hm16 by aligning it to the mmtv pol gene and then compared these sequences with other retroviral pol protein sequences .
organism_has_gene
{ "id": "C0035366", "name": "retroviral", "pos": [ 134, 144 ] }
{ "id": "C0017360", "name": "pol", "pos": [ 145, 148 ] }
cells expressing human or murine class i heavy chains can exchange their native beta 2m for exogenously added free beta 2m , which is present in serum .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 17, 22 ] }
{ "id": "C1420192", "name": "heavy chains", "pos": [ 41, 53 ] }
the ability of human observers to detect vernier breaks of as little as 5 s arc has been termed hyperacuity as this distance is substantially less than the angular separation of the bars of the highest spatial frequency of grating ( approximately 1 arc min ) that can be detected .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 15, 20 ] }
{ "id": "C1707156", "name": "bars", "pos": [ 182, 186 ] }
the complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 36, 41 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 46, 54 ] }
the complete 648 amino acid sequence of the human raf oncogene was deduced from the 2977 nucleotide sequence of a fetal liver cdna .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 44, 49 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 54, 62 ] }
structure and nucleotide sequence of the 5 ' region of the human and feline c-sis proto-oncogenes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 59, 64 ] }
{ "id": "C0037207", "name": "sis", "pos": [ 78, 81 ] }
hybridization analysis of human and feline c-sis containing cosmid clones with a mixed synthetic nucleotide probe , which corresponded to sequences encoding amino acid residues 2-7 of chain 1 of platelet-derived growth factor ( pdgf-1 ) , suggested that the c-sis cosmid clones did not include pdgf-1-specific genetic sequences .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 26, 31 ] }
{ "id": "C0751995", "name": "c-sis", "pos": [ 258, 263 ] }
in the current report , a probe derived from one of these cdna clones , pb8 , was used for in situ hybridization experiments to map the human gene for apob , apob , to the distal half of the short arm of chromosome 2 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 136, 141 ] }
{ "id": "C1412471", "name": "gene", "pos": [ 142, 146 ] }
measurements of running in the cat and human show that the feet and body sometimes move as predicted by the even and odd symmetry functions .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 39, 44 ] }
{ "id": "C1415068", "name": "odd", "pos": [ 117, 120 ] }
rat mhc ( rt.1 ) class i genes were analyzed by performing southern blot analysis of digests of genomic dna isolated from three inbred rat strains using a human derived hla cdna probe specific for class i genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 155, 160 ] }
{ "id": "C0017355", "name": "class i genes", "pos": [ 197, 210 ] }
when human skin fibroblast extracts were subjected to sodium dodecylsulfate-polyacrylamide gel electrophoresis followed by electroblotting and immunochemical staining using monospecific antibodies against sap-2 , two or three major bands with estimated mol . wts . of 9,000-10,000 were found .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 5, 10 ] }
{ "id": "C1705714", "name": "wts", "pos": [ 259, 262 ] }
the human asialoglycoprotein receptor is a heterooligomer of the two homologous subunits h1 and h2 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0919509", "name": "h2", "pos": [ 96, 98 ] }
expression of the human homolog of myod1 therefore can define a tumor as a rhabdomyosarcoma .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 18, 23 ] }
{ "id": "C1417574", "name": "myod1", "pos": [ 35, 40 ] }
human gliomas were imaged in vivo using ligands for the peripheral-type benzodiazepine binding site ( or omega 3 binding site ) and positron emission tomography ( pet ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1823521", "name": "peripheral", "pos": [ 56, 66 ] }
normal human fibroblasts ( mrc-5 , kms-6 ) were compared to transformed derivatives induced by sv40 ( mrc-5v1 ) or gamma rays ( kmst-6 ) for the expression of nuclear proteins that interact with the genome of minute virus of mice ( mvmp ) , using the southwestern blot technique .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 7, 12 ] }
{ "id": "C1704944", "name": "kms", "pos": [ 128, 131 ] }
the major reducible cross-link synthesized by cultured human umbilical arterial and venous endothelium is dihydroxylysinonorleucine ( di-oh-lnl ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 55, 60 ] }
{ "id": "C3538902", "name": "di", "pos": [ 134, 136 ] }
1h nmr spectra of a gdp/gtp-binding domain of human c-ha-ras gene product ( residues 1-171 ) in which glutamine-61 was replaced by leucine [ ras ( l61/1-171 ) protein ] were analyzed .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 46, 51 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 141, 144 ] }
the human ras genes , h-ras , k-ras and n-ras , are members of a family of proto-oncogenes that are targets for mutational changes that convert these normal genes into active , transforming oncogenes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1705572", "name": "h-ras", "pos": [ 22, 27 ] }
the human ras genes , h-ras , k-ras and n-ras , are members of a family of proto-oncogenes that are targets for mutational changes that convert these normal genes into active , transforming oncogenes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 42, 45 ] }
the human ras genes , h-ras , k-ras and n-ras , are members of a family of proto-oncogenes that are targets for mutational changes that convert these normal genes into active , transforming oncogenes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0809246", "name": "n-ras", "pos": [ 40, 45 ] }
the human ras genes , h-ras , k-ras and n-ras , are members of a family of proto-oncogenes that are targets for mutational changes that convert these normal genes into active , transforming oncogenes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0029016", "name": "oncogenes", "pos": [ 190, 199 ] }
universally immunogenic t cell epitopes : promiscuous binding to human mhc class ii and promiscuous recognition by t cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 65, 70 ] }
{ "id": "C0017349", "name": "mhc class", "pos": [ 71, 80 ] }
to understand the effect of human mhc class ii polymorphism on antigen recognition , we analyzed the memory t cell response to three tetanus toxin epitopes defined by three short synthetic peptides ( p2 , p4 and p30 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 28, 33 ] }
{ "id": "C0017349", "name": "mhc class ii", "pos": [ 34, 46 ] }
splicing sites for exons 4 to 12 , which encode both conserved phospholipase-c-like and catalytic domains of the src-like ptks , arise exactly at the same position for the human lck , human c-src and c-fgr genes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 172, 177 ] }
{ "id": "C1708019", "name": "c-fgr genes", "pos": [ 200, 211 ] }
the human mdr1 gene encoding p-glycoprotein , an energy-dependent drug-efflux pump , was initially isolated from a multidrug-resistant kb carcinoma cell .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0376623", "name": "mdr1 gene", "pos": [ 10, 19 ] }
transuterine puncture during transvaginal oocyte retrieval does not seem to have an adverse effect on the results of human ivf and zift treatment .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 117, 122 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 123, 126 ] }
improvement of survival and fertilizing capacity of human spermatozoa in an ivf programme by selection on discontinuous percoll gradients .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 52, 57 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 76, 79 ] }
a possible effect of stress on the ability of spermatozoa to fertilize human oocytes in vitro was analysed in the present study composed of 26 couples with normozoospermic men undergoing ivf .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 71, 76 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 187, 190 ] }
regional variation in langerhans cell distribution and density in normal human oral mucosa determined using monoclonal antibodies against cd1 , hladr , hladq and hladp .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 73, 78 ] }
{ "id": "C2348921", "name": "hladp", "pos": [ 162, 167 ] }
the human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger rnas .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C1366439", "name": "sex hormone-binding globulin gene", "pos": [ 10, 43 ] }
ras mutations in human melanotic lesions : k-ras activation is a frequent and early event in melanoma development .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 17, 22 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 45, 48 ] }
southern blotting analyses of mouse-human somatic cell hybrids from this human t-all sample and chinese hamster-human somatic cell hybrids derived from wilms ' tumor lines have indicated that the 11p13 locus , tcl-2 , juxtaposed to the tcr ( t cell receptor ) delta locus in t cell leukemia , is within the constitutional deletion of two wilms ' tumor-aniridia cases .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 36, 41 ] }
{ "id": "C1412532", "name": "tcl", "pos": [ 210, 213 ] }
half the library was screened with the human dqa , dqb , dra and drb cdna probes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 39, 44 ] }
{ "id": "C1335836", "name": "dra", "pos": [ 57, 60 ] }
we have previously reported that a human nuclear factor , probably corresponding to the usf/mltf protein [ 1,2 ] , is able to bind specifically to a dna sequence present in dna replicated at the onset of s-phase [ 3 ] .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 35, 40 ] }
{ "id": "C1421376", "name": "mltf", "pos": [ 92, 96 ] }
spin-labeling proton nmr study on aromatic amino acid residues in the guanine nucleotide binding site of human c-ha-ras ( 1-171 ) protein .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 105, 110 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 116, 119 ] }
in the present study , we used southern hybridization analysis to examine dna from 79 primary and 11 recurrent human breast cancers for evidence of activation of int-2 through either gene rearrangement or amplification .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 111, 116 ] }
{ "id": "C1708016", "name": "int-2", "pos": [ 162, 167 ] }
these findings confirm and extend earlier results of studies of int-2 , c-erbb-2 and c-myc amplification in human breast cancers and point to a role for int-2 activation in certain cases of recurrent breast malignant neoplasia .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 108, 113 ] }
{ "id": "C1708016", "name": "int-2", "pos": [ 153, 158 ] }
we have found that human retinal pigment epithelial ( rpe ) cells grown in vitro transcribe the bfgf gene and synthesize a peptide that crossreacts with anti-bfgf antibodies .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 19, 24 ] }
{ "id": "C1708015", "name": "bfgf gene", "pos": [ 96, 105 ] }
a depletion of this innervation has been reported in a number of human neurodegenerative conditions ( including alzheimer 's disease ) and may contribute to the genesis of the associated behavioral disturbances .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 65, 70 ] }
{ "id": "C1414672", "name": "genesis", "pos": [ 161, 168 ] }
the ras oncogene and tumour metastasis : observations on murine cells transfected with activated human c-ha-ras .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 97, 102 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 108, 111 ] }
the results in this experimental system indicate that transfection of a mutated human ras oncogene into non-neoplastic 3t3 cells can confer part of the metastatic phenotype , namely lung colonisation , but is not by itself sufficient to induce spontaneous metastatic behaviour .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 80, 85 ] }
{ "id": "C0034678", "name": "ras oncogene", "pos": [ 86, 98 ] }
we also observed that expression of a hybrid human hsp70 promoter/cat gene , lacking myb-specific binding sites , was activated by v-myb .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 45, 50 ] }
{ "id": "C0026900", "name": "v-myb", "pos": [ 131, 136 ] }
a new vector using the human multidrug resistance gene as a selectable marker enables overexpression of foreign genes in eukaryotic cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 23, 28 ] }
{ "id": "C0376623", "name": "multidrug resistance gene", "pos": [ 29, 54 ] }
the vector uses the human multidrug resistance gene , mdr1 , as a dominant selectable marker and contains an additional transcription unit plus a unique sali cloning site for inserting nucleotide sequences to be expressed .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 20, 25 ] }
{ "id": "C0376623", "name": "multidrug resistance gene", "pos": [ 26, 51 ] }
the vector uses the human multidrug resistance gene , mdr1 , as a dominant selectable marker and contains an additional transcription unit plus a unique sali cloning site for inserting nucleotide sequences to be expressed .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 20, 25 ] }
{ "id": "C0376622", "name": "mdr1", "pos": [ 54, 58 ] }
under maximal stimulus conditions , a cytostatic effect resulted from exposing hcec to : alpha or gamma ifn ( greater than or equal to 1000 u/ml ) , tgf beta ( greater than or equal to 5 ng/ml ) , ril-1 ( greater than or equal to 0.5 u/ml ) and ril-1 plus gamma ifn .
organism_has_gene
{ "id": "C0086418", "name": "hcec", "pos": [ 79, 83 ] }
{ "id": "C1335621", "name": "ril", "pos": [ 245, 248 ] }
here we report a human gastric cancer which bore co-amplified c-myc and c-erbb-2 oncogenes : a portion of the amplified c-erbb-2 oncogene was found to be rearranged .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 17, 22 ] }
{ "id": "C0086661", "name": "c-myc", "pos": [ 62, 67 ] }
here we report a human gastric cancer which bore co-amplified c-myc and c-erbb-2 oncogenes : a portion of the amplified c-erbb-2 oncogene was found to be rearranged .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 17, 22 ] }
{ "id": "C0243036", "name": "erbb", "pos": [ 122, 126 ] }
here we report a human gastric cancer which bore co-amplified c-myc and c-erbb-2 oncogenes : a portion of the amplified c-erbb-2 oncogene was found to be rearranged .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 17, 22 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 129, 137 ] }
human amniotic fluid for fertilization and culture of human embryos : results of clinical trials in human in vitro fertilization ( ivf ) programs .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C1419864", "name": "ivf", "pos": [ 131, 134 ] }
the results show that although the trypanocidal factor is contained within the high density lipoprotein ( hdl ) fraction of human serum , it is apparently not one of the major apolipoproteins of the hdl complex such as apolipoprotein a-i , a-ii , or apolipoprotein b .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 124, 129 ] }
{ "id": "C1412468", "name": "of", "pos": [ 192, 194 ] }
the phylogeny and patterns of nucleotide substitutions in the visual pigment genes , adrenergic receptor genes , muscarinic receptor genes , and in the human mas oncogene were studied by comparing their dna sequences .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 152, 157 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 162, 170 ] }
expression vectors encoding cdnas for the human platelet-derived growth factor ( pdgf ) a-chain ( pjkl ) and murine dihydrofolate reductase ( ptkdhfr ) were cotransfected into dihydrofolate reductase-deficient chinese hamster ovary cells .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 42, 47 ] }
{ "id": "C1335200", "name": "platelet-derived growth factor", "pos": [ 48, 78 ] }
the effect of the hydrolysis on hybridization results was studied by measuring in solution the hybridization kinetics of the crnas of another human oncogene , n-myc .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 142, 147 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 148, 156 ] }
the effect of the hydrolysis on hybridization results was studied by measuring in solution the hybridization kinetics of the crnas of another human oncogene , n-myc .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 142, 147 ] }
{ "id": "C0812287", "name": "n-myc", "pos": [ 159, 164 ] }
when human plasminogen ( glu-pga ) is activated by urokinase in the presence of pancreatic trypsin inhibitor , the plasmin produced ( glu-pma ) exclusively contains a heavy chain ( glu-ha ) derived intact from the original nh2 terminus of glu-pga .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 5, 10 ] }
{ "id": "C1420192", "name": "heavy chain", "pos": [ 167, 178 ] }
the test-substances comprised a glycoprotein with human blood group p1 and pk activity isolated from sheep hydatid cyst fluid , fragments isolated from the partial acid hydrolysis products of the p1pk active glycoprotein , glycolipids , monosaccharides and di- and oligo-saccharides of known structure .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 50, 55 ] }
{ "id": "C3538902", "name": "di", "pos": [ 257, 259 ] }
it explains the cloning of oncogenes , the relation existing between the different human cellular oncogenes , and between human oncogenes and retrovirus oncogenes , and the alteration of the dna nucleotide sequence conducing to transforming activity .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 83, 88 ] }
{ "id": "C0029016", "name": "oncogenes", "pos": [ 153, 162 ] }
the initial definition by direct cytotoxicity assay was confirmed by absorption of reactions against target t lymphocytes , thus avoiding problems due to contaminating ia antibodies , and by blocking the reactions by pretreatment with a chicken anti-human beta2 microglobulin serum .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 250, 255 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 256, 261 ] }
it has previously been reported that somatic cell hybrids with daudi , which contain chromosome 15 , do not express human beta2 microglobulin .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 116, 121 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 122, 127 ] }
primate hla antibodies are specifically mitogenic for human lymphocytes and act synergistically with beta2m antibodies .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 54, 59 ] }
{ "id": "C1417683", "name": "beta2m", "pos": [ 101, 107 ] }
southern blot analysis of the transformants obtained with the methylated or mock-methylated pt24-c3 plasmids indicated in all the examined dnas the presence of human ha-ras sequences with methylation degrees consistent with the treatment of the plasmids .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 160, 165 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 169, 172 ] }
southern blot analysis showed integration of human ha-ras with a methylation profile intermediate between the double-methylated and mock-methylated plasmids .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 45, 50 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 54, 57 ] }
cloned mouse r-ras cdnas exhibit 88 % nucleotide and 94.5 % predicted amino acid identity to human r-ras .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 93, 98 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 101, 104 ] }
binding sites for ctf in the human ha-ras and alpha-globin promoters were highly homologous to sequences recognized by nuclear factor i ( nf-i ) , a cellular dna-binding protein that is required for the initiation of adenovirus dna replication in vitro .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 29, 34 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 38, 41 ] }
to examine the molecular basis of one type of multidrug resistance , we have prepared rna from human tumors and normal tissues and measured their content of mdr1 rna .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 95, 100 ] }
{ "id": "C0376622", "name": "mdr1", "pos": [ 157, 161 ] }
our previous work demonstrated that nih-3t3 mouse cells expressing high levels of the cellular ras oncogene isolated from the ej human bladder carcinoma ( ej-ras ) exhibited reduced hormone-stimulated adenylate cyclase activity .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 129, 134 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 158, 161 ] }
we have determined the total coding sequence of human c-yes , a non-receptor type protein-tyrosine kinase gene , and found that the c-yes gene closely resembles the c-src gene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 48, 53 ] }
{ "id": "C0812329", "name": "non-receptor", "pos": [ 64, 76 ] }
we have determined the total coding sequence of human c-yes , a non-receptor type protein-tyrosine kinase gene , and found that the c-yes gene closely resembles the c-src gene .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 48, 53 ] }
{ "id": "C1710701", "name": "c-yes gene", "pos": [ 132, 142 ] }
primary human hepatocellular carcinomas ( hcc ) were surveyed for oncogenes by transformation assays using nih 3t3 cells and calcium phosphate coprecipitation method .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 8, 13 ] }
{ "id": "C0029016", "name": "oncogenes", "pos": [ 66, 75 ] }
we have shown that dna from mnng-hos cells will transform nih/3t3 cells and have isolated greater than 35 kb of human dna containing an oncogene , termed met .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 112, 117 ] }
{ "id": "C0029016", "name": "oncogene", "pos": [ 136, 144 ] }
both human and yeast ras proteins can stimulate the magnesium and guanine nucleotide-dependent adenylate cyclase activity present in yeast membranes .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 5, 10 ] }
{ "id": "C0034678", "name": "ras", "pos": [ 21, 24 ] }
we attempted to produce transgenic mice harboring the normal or activated human c-ha-ras gene in order to examine the function of activated oncogenes in tumorigenesis .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 74, 79 ] }
{ "id": "C0029016", "name": "oncogenes", "pos": [ 140, 149 ] }
the human homologue of the v-sis oncogene encodes one chain of human platelet-derived growth factor ( pdgf-2 ) .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 4, 9 ] }
{ "id": "C0037207", "name": "v-sis oncogene", "pos": [ 27, 41 ] }
the comparison of cerv orf5 with camv orfv highlighted regions which show homologies to retrovirus gag/pol protease , rnase h and dna polymerase domains ;
organism_has_gene
{ "id": "C0035366", "name": "retrovirus", "pos": [ 88, 98 ] }
{ "id": "C0017360", "name": "pol", "pos": [ 134, 137 ] }
isolated horse monocytes represent an alternative sensitive source of indicator cells for human mif assays , whereas guinea pig peritoneal exudate macrophages appear to be less sensitive and to show large individual variations in sensitivity to human mif .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 90, 95 ] }
{ "id": "C3538735", "name": "mif", "pos": [ 251, 254 ] }
clones with lytic activity against either phytohemagglutinin-induced blast cells bearing the stimulating alloantigen ( s ) ( cytotoxic t lymphocyte [ ctl ] activity ) , l1210 mouse lymphoma cells coated with rabbit antibody ( antibody-dependent cell-mediated cytotoxicity [ adcc ] ) , or k562 human target cells were selected , expanded , and then analyzed for different surface markers , including rosette formation with sheep erythrocytes ( e rosettes ) , receptors for the fc portion of igg or igm ( fc gamma r and fc mu r ) , and a group of antigens recognized by monoclonal antibodies including ia , 4f2 , okt8 , a nd okt4 .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 293, 298 ] }
{ "id": "C1420192", "name": "4f2", "pos": [ 605, 608 ] }
a xenograft of human choriocarcinoma ( cc3 ) has been established in nude mice , and the relative distribution of affinity-purified specific antibodies to human chorionic gonadotrophin has been compared with that of nonspecific antibodies from the same species .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 15, 20 ] }
{ "id": "C1333930", "name": "cc3", "pos": [ 39, 42 ] }
the inhibitory activity by human autoantibodies but not by rabbit anti-human beta2m antibodies was diminished when incubation was performed at 37 degrees c instead of 20 degrees c .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 27, 32 ] }
{ "id": "C1417683", "name": "beta2m", "pos": [ 77, 83 ] }
an antigenic determinant of human beta 2-microglobulin masked by the association with hla heavy chains at the cell surface : analysis using monoclonal antibodies .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 28, 33 ] }
{ "id": "C1420192", "name": "heavy chains", "pos": [ 90, 102 ] }
the complete blocking of mta activity by pretreating the anti-beta2-microglobulin adsorbent with beta2-microglobulin and the lack of detectable mta binding to a sepharose anti-normal human serum adsorbent demonstrated the specificity of the binding of mta to the anti-beta2-microglobulin adsorbent .
organism_has_gene
{ "id": "C0086418", "name": "human", "pos": [ 183, 188 ] }
{ "id": "C1417683", "name": "beta2", "pos": [ 268, 273 ] }