text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
analysis of site of infection showed a preponderance of abdominal infections in liver patients , intrathoracic infections in heart patients , and urinary tract infections in renal patients . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
20,
29
]
} | {
"id": "C1112209",
"name": "abdominal infections",
"pos": [
56,
76
]
} |
analysis of site of infection showed a preponderance of abdominal infections in liver patients , intrathoracic infections in heart patients , and urinary tract infections in renal patients . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
20,
29
]
} | {
"id": "C0042029",
"name": "urinary tract infections",
"pos": [
146,
170
]
} |
there was resistance to sulfisoxazole ( 78 % ) , tetracycline ( 69 % ) , kanamycin ( 61 % ) , ampicillin ( 56 % ) , streptomycin ( 53 % ) , chloramphenicol ( 38 % ) and mezlocillin ( 38 % ) . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
94,
104
]
} | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
169,
180
]
} |
the commonest form of generalised epilepsy was grand mal and that of partial epilepsy was partial epilepsy with complex symptomatology . | NA | {
"id": "C0014548",
"name": "generalised epilepsy",
"pos": [
22,
42
]
} | {
"id": "C0014549",
"name": "grand",
"pos": [
47,
52
]
} |
the commonest form of generalised epilepsy was grand mal and that of partial epilepsy was partial epilepsy with complex symptomatology . | NA | {
"id": "C0014547",
"name": "partial epilepsy",
"pos": [
69,
85
]
} | {
"id": "C0085417",
"name": "partial epilepsy",
"pos": [
90,
106
]
} |
sensitivity tests on strains from 11 patients with pulmonary tuberculosis , previously treated with kanamycin and/or capreomycin , showed incomplete cross-resistance between amikacin and capreomycin but complete cross-resistance between amikacin and kanamycin . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
174,
182
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
250,
259
]
} |
treatment with amikacin of 4 patients with multiply resistant strains resulted in no response as assessed by sputum smears and cultures , but resistance emerged to amikacin , kanamycin and capreomycin . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
15,
23
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
175,
184
]
} |
amikacin has no role in the treatment of tuberculosis as it can not be given as an alternative to kanamycin , has no advantages over it and is more expensive . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
0,
8
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
98,
107
]
} |
since the diver was participating in evaluation of experimental decompression tables , differentiation had to be made between barotrauma and inner ear decompression sickness . | NA | {
"id": "C0004760",
"name": "barotrauma",
"pos": [
126,
136
]
} | {
"id": "C0011119",
"name": "decompression",
"pos": [
151,
164
]
} |
the contents of camp and cgmp , adrenaline , noradrenaline and serotonin in the blood were studied in 96 patients with surgical pathology of lungs . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
32,
42
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
45,
58
]
} |
antibody raised early in the response was sensitive to treatment with 2-mercaptoethanol ( 2-me ) suggesting that igm was the predominant class of immunoglobulin . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0021017",
"name": "class",
"pos": [
137,
142
]
} |
in nodular sclerosis these cells with fibroblast morphology are consistently numerous in the marginal zones of the cellular nodes . | NA | {
"id": "C0016030",
"name": "cells",
"pos": [
27,
32
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
115,
123
]
} |
however , ltk+ cells that were transformed with the plasmid pvbt2tk-1 and which synthesized a truncated t antigen of 12.3 k did not provide a target for sv40 ctl nor did pvbetk-1-transformed cells that did not express any of the sv40 tumor antigens . | NA | {
"id": "C0003343",
"name": "t antigen",
"pos": [
104,
113
]
} | {
"id": "C0003335",
"name": "tumor antigens",
"pos": [
234,
248
]
} |
when the cells were exposed to the virus and assessed by immunofluorescence and immunoprecipitation , ea induction occurred significantly ( 17 % ) but not vca ( less than 1 % ) , at a low-input multiplicity of infection ( moi ) of 10 ebv dna copies/cell . | NA | {
"id": "C0003320",
"name": "ea",
"pos": [
102,
104
]
} | {
"id": "C0003342",
"name": "vca",
"pos": [
155,
158
]
} |
in contrast , at a high moi of 500 ebv dna copies/cell , the majority of cells were positive for both ea ( 82 % ) and vca ( 61 % ) . | NA | {
"id": "C0003320",
"name": "ea",
"pos": [
102,
104
]
} | {
"id": "C0003342",
"name": "vca",
"pos": [
118,
121
]
} |
kinetic studies showed that ea induction was directly proportional to the dilution of the infecting virus , while vca was made following three-hit kinetics . | NA | {
"id": "C0003320",
"name": "ea",
"pos": [
28,
30
]
} | {
"id": "C0003342",
"name": "vca",
"pos": [
114,
117
]
} |
we have investigated the expression of human interferon ( ifn ) -related transcripts in sendai virus-induced lymphoblastoid ( namalwa ) cells and in poly ( i ) x poly ( c ) -induced fibroblast ( fs-4 ) cells by electrophoresis of rna through agarose-ch3hgoh gels followed by ( a ) blot hybridization of the rna using ifn-alpha 1 and ifn-beta 1 cdna probes , and ( b ) translation of the eluted rna into biologically active ifn using the xenopus laevis oocyte assay . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
182,
192
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
202,
207
]
} |
most of the hpv dna sequences in the cotransformed cells were not present as unit-length episomal viral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
16,
19
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
98,
107
]
} |
additional comparisons of these nuclear and virion proteins established that the virion 69k protein ( v69 ) differs in electrophoretic mobility and net charge from the nuclear 69k protein but that it , as well as the virion 66k protein , has a two-dimensional phosphopeptide pattern similar to its nuclear counterpart . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
32,
39
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
228,
235
]
} |
functional mapping of the epstein-barr virus genome : identification of sites coding for the restricted early antigen , the diffuse early antigen , and the nuclear antigen . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
110,
117
]
} | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
156,
171
]
} |
alignment of endonuclease-resistant proto-fps and viral dna fragments relative to common rnase t1-resistant oligonucleotide sequences of viral rna , identified by fingerprinting dna-rna hybrids , indicated : ( i ) that proto-fps is colinear with viral fps but is interrupted by 1.75 kb of scattered sequences unrelated to viral fps ; | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
137,
146
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
182,
185
]
} |
cholesterol esters showed a rise in the content of cholesterol linolenate , cholesterol oleate and cholesterol palmitate . | NA | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
0,
18
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
99,
110
]
} |
elevated paigm was most often associated with elevated paigg except for the following : 2 patients with lymphoproliferative disorders , 1 patient with heparin-induced thrombocytopenia , 1 patient with pernicious anemia , and 2 patients with waldenstrom 's macroglobulinemia . | NA | {
"id": "C0024314",
"name": "lymphoproliferative",
"pos": [
104,
123
]
} | {
"id": "C0024419",
"name": "waldenstrom 's macroglobulinemia",
"pos": [
241,
273
]
} |
analysis of distribution of antigenic determinants and nonimmunogenic areas of hemagglutinin in the strains tested showed the drift nature of changes of the hemagglutinin antigenic properties . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
28,
50
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
171,
180
]
} |
comparative studies of remantadine-sensitive and resistant variants of the classic fowl plague virus showed the previously demonstrated significant differences in the physico-chemical properties of m protein of these variants to correlate with a marked antigenic divergence associated , in particular , with greater antigenicity of b4 epitope in m protein of remantadine-sensitive strains . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
253,
262
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
335,
342
]
} |
the virus produced by transfection of bhk-21 cells differed from that produced in chick fibroblast and monkey kidney cultures in electrophoretic mobility of virion envelope proteins . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
45,
50
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
88,
98
]
} |
the six target diseases are : malaria , schistosomiasis , filariasis , trypanosomiasis ( both african sleeping sickness and chagas ' disease ) , leishmaniasis and leprosy . | NA | {
"id": "C0041227",
"name": "trypanosomiasis",
"pos": [
71,
86
]
} | {
"id": "C0041228",
"name": "african sleeping sickness",
"pos": [
94,
119
]
} |
the six target diseases are : malaria , schistosomiasis , filariasis , trypanosomiasis ( both african sleeping sickness and chagas ' disease ) , leishmaniasis and leprosy . | NA | {
"id": "C0041227",
"name": "trypanosomiasis",
"pos": [
71,
86
]
} | {
"id": "C0041234",
"name": "chagas",
"pos": [
124,
130
]
} |
adrenaline remained unchanged , while noradrenaline had a tendency to decrease only slightly during submaximal work load and was significantly lower during maximal work load . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
38,
51
]
} |
the validity of two-dimensional echocardiography ( 2-d echo ) and computed tomography ( ct ) in the detection of intra- and paracardial tumors and thrombi was compared in 32 patients : 7 endocardial myxomas , 1 left ventricular fibroma , 2 paracardial cysts , 1 paracardial tumor , and 21 thrombi . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
252,
257
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
274,
279
]
} |
[ characterization of shock sensitivity in experimental hemorrhagic shock ( 5,3 and 8,0 kpa ) by determining kallikrein , kallikreinogen , non-specific proteases and inhibitor capacity of blood plasma ] . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
109,
119
]
} | {
"id": "C0033024",
"name": "kallikreinogen",
"pos": [
122,
136
]
} |
during hemorrhagic shock after 40 % blood loss lactate uptake decreased sharply and ceased almost totally . | NA | {
"id": "C0036982",
"name": "hemorrhagic shock",
"pos": [
7,
24
]
} | {
"id": "C0019080",
"name": "blood loss",
"pos": [
36,
46
]
} |
during the last five years , when reporting of severe adverse drug reactions was mandatory , the incidence of severe diar per unit administered was 0.013 % for dextran 40 and 0.025 % for dextran 70 . | NA | {
"id": "C0086140",
"name": "diar",
"pos": [
117,
121
]
} | {
"id": "C0011793",
"name": "dextran 40",
"pos": [
160,
170
]
} |
during the last five years , when reporting of severe adverse drug reactions was mandatory , the incidence of severe diar per unit administered was 0.013 % for dextran 40 and 0.025 % for dextran 70 . | NA | {
"id": "C0086140",
"name": "diar",
"pos": [
117,
121
]
} | {
"id": "C0011795",
"name": "dextran 70",
"pos": [
187,
197
]
} |
we found a male : female ratio of 1.5 : 1 for all diar while for the most severe diar this ratio was 3 : 1 . | NA | {
"id": "C0717685",
"name": "1",
"pos": [
34,
35
]
} | {
"id": "C0086140",
"name": "diar",
"pos": [
81,
85
]
} |
fatal diar occurred even after infusion of only 0.5-1 ml of dextran , and we strongly advise against the use of `` '' biological test-doses '' '' . | NA | {
"id": "C0086140",
"name": "diar",
"pos": [
6,
10
]
} | {
"id": "C0717685",
"name": "1",
"pos": [
52,
53
]
} |
the incidence of dextran-induced anaphylactoid/anaphylactic reactions ( diar ) was investigated after hapten inhibition employing two different modes of administration of dextran 1 ( mw 1 000 dalton ) . | NA | {
"id": "C0086140",
"name": "dextran",
"pos": [
17,
24
]
} | {
"id": "C0717685",
"name": "dextran 1",
"pos": [
171,
180
]
} |
they were randomized into two groups -- one receiving a mixture of 20 ml dextran 1 , 15 % , ( promiten ) and 500 ml dextran 70 ( macrodex ) or dextran 40 ( rheomacrodex ) ( admixture group ) , the other receiving an intravenous injection of 20 ml dextran 1 , 15 % before the infusion of dextran 70 or 40 ( preinjection group ) . | NA | {
"id": "C0717685",
"name": "dextran 1",
"pos": [
73,
82
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
287,
294
]
} |
they were randomized into two groups -- one receiving a mixture of 20 ml dextran 1 , 15 % , ( promiten ) and 500 ml dextran 70 ( macrodex ) or dextran 40 ( rheomacrodex ) ( admixture group ) , the other receiving an intravenous injection of 20 ml dextran 1 , 15 % before the infusion of dextran 70 or 40 ( preinjection group ) . | NA | {
"id": "C0011795",
"name": "dextran 70",
"pos": [
116,
126
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
287,
294
]
} |
they were randomized into two groups -- one receiving a mixture of 20 ml dextran 1 , 15 % , ( promiten ) and 500 ml dextran 70 ( macrodex ) or dextran 40 ( rheomacrodex ) ( admixture group ) , the other receiving an intravenous injection of 20 ml dextran 1 , 15 % before the infusion of dextran 70 or 40 ( preinjection group ) . | NA | {
"id": "C0011793",
"name": "dextran 40",
"pos": [
143,
153
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
287,
294
]
} |
the admixture of dextran 1 to dextran 70 or 40 does not prevent the occurrence of severe diar in the dose investigated . | NA | {
"id": "C0717685",
"name": "dextran 1",
"pos": [
17,
26
]
} | {
"id": "C0086140",
"name": "diar",
"pos": [
89,
93
]
} |
the admixture of dextran 1 to dextran 70 or 40 does not prevent the occurrence of severe diar in the dose investigated . | NA | {
"id": "C0011795",
"name": "dextran 70",
"pos": [
30,
40
]
} | {
"id": "C0086140",
"name": "diar",
"pos": [
89,
93
]
} |
in an open , prospective multi-center study prevention of dextran-induced anaphylactic reactions ( diar ) was attempted by intravenous injection of 20 ml dextran 1 , 15 % , mw 1000 dalton , ( promiten ) , two minutes before start of infusion of dextran 70 ( macrodex ) or dextran 40 ( rheomacrodex ) . | NA | {
"id": "C0086140",
"name": "dextran",
"pos": [
58,
65
]
} | {
"id": "C0717685",
"name": "dextran 1",
"pos": [
154,
163
]
} |
in an open , prospective multi-center study prevention of dextran-induced anaphylactic reactions ( diar ) was attempted by intravenous injection of 20 ml dextran 1 , 15 % , mw 1000 dalton , ( promiten ) , two minutes before start of infusion of dextran 70 ( macrodex ) or dextran 40 ( rheomacrodex ) . | NA | {
"id": "C0086140",
"name": "dextran",
"pos": [
58,
65
]
} | {
"id": "C0011793",
"name": "dextran 40",
"pos": [
272,
282
]
} |
the incidence of severe diar after preinjection of 20 ml dextran 1 is significantly lower than that after injection of 10 ml dextran 1 ( p = 0.01 ) , and is also markedly lower than that of a large swedish historical control material ( 0.037-0.050 % ) . | NA | {
"id": "C0086140",
"name": "diar",
"pos": [
24,
28
]
} | {
"id": "C0717685",
"name": "dextran 1",
"pos": [
125,
134
]
} |
it is recommended that patients who are going to receive dextran 70 or 40 are given a prophylactic i.v . injection of 20 ml dextran 1 before the first unit of clinical dextran to minimize the risk of severe diar . | NA | {
"id": "C0011795",
"name": "dextran 70",
"pos": [
57,
67
]
} | {
"id": "C0086140",
"name": "diar",
"pos": [
207,
211
]
} |
it is recommended that patients who are going to receive dextran 70 or 40 are given a prophylactic i.v . injection of 20 ml dextran 1 before the first unit of clinical dextran to minimize the risk of severe diar . | NA | {
"id": "C0717685",
"name": "dextran 1",
"pos": [
124,
133
]
} | {
"id": "C0086140",
"name": "diar",
"pos": [
207,
211
]
} |
it was found that insulin , but not modified sham feeding , caused a marked increase in plasma adrenaline and noradrenaline concentrations whereas gastric acid secretion was of a similar magnitude in the two tests . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
95,
105
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
110,
123
]
} |
the incidence of severe dextran-induced anaphylactic reaction ( diar ) in sweden during 1975-1979 was 0.025 per unit of dextran 70 , equivalent to 0.037-0.05 per patient . | NA | {
"id": "C0086140",
"name": "dextran",
"pos": [
24,
31
]
} | {
"id": "C0011795",
"name": "dextran 70",
"pos": [
120,
130
]
} |
the prevention of diar by hapten inhibition was attempted in three multicenter studies using dextran 1 ( mw 1 000 daltons ) employing different doses and modes of administration . | NA | {
"id": "C0086140",
"name": "diar",
"pos": [
18,
22
]
} | {
"id": "C0717685",
"name": "dextran 1",
"pos": [
93,
102
]
} |
after injection of 20 ml dextran 1 before infusion of clinical dextran in 41 099 patients only one patient developed severe diar ( 0.002 % ) , which is significantly lower than the incidence observed after the preinjection of half this dose in 29 252 patients ( 0.024 % ) . | NA | {
"id": "C0717685",
"name": "dextran 1",
"pos": [
25,
34
]
} | {
"id": "C0086140",
"name": "diar",
"pos": [
124,
128
]
} |
admixture of 20 ml dextran 1 to 500 ml clinical dextran did not prevent fatal diar . | NA | {
"id": "C0717685",
"name": "dextran 1",
"pos": [
19,
28
]
} | {
"id": "C0086140",
"name": "diar",
"pos": [
78,
82
]
} |
the gaba analogue , baclofen , and the dopamine antagonist , metoclopramide , were studied with respect to their effects on basal and lrh-induced lh and fsh release in 6 normal male volunteers . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
4,
8
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
20,
28
]
} |
should such symptoms develop in a patient with a previous history of thyrotoxicosis , the possibility of thyroid storm should be considered . | NA | {
"id": "C0040156",
"name": "thyrotoxicosis",
"pos": [
69,
83
]
} | {
"id": "C0040127",
"name": "thyroid storm",
"pos": [
105,
118
]
} |
the results indicate that an organic brain damage can not be the sole cause of dcs , and it is suggested that some of the symptoms are manifestations of a stress response syndrome provoked by insufficient coping with the consequences of the disease . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
171,
179
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
241,
248
]
} |
all cases of motor neuron disease ( mnd ) , encompassing amyotrophic lateral sclerosis ( als ) , progressive bulbar paralysis ( pbp ) and progressive spinal muscular atrophy ( psma ) , in northern sweden , diagnosed between 1969-1980 have been analysed . | NA | {
"id": "C0085084",
"name": "motor neuron disease",
"pos": [
13,
33
]
} | {
"id": "C0002736",
"name": "amyotrophic lateral",
"pos": [
57,
76
]
} |
all cases of motor neuron disease ( mnd ) , encompassing amyotrophic lateral sclerosis ( als ) , progressive bulbar paralysis ( pbp ) and progressive spinal muscular atrophy ( psma ) , in northern sweden , diagnosed between 1969-1980 have been analysed . | NA | {
"id": "C0085084",
"name": "motor neuron disease",
"pos": [
13,
33
]
} | {
"id": "C0030442",
"name": "progressive bulbar paralysis",
"pos": [
97,
125
]
} |
ca is a rare , inherited syndrome characterized by normolipoproteinemic acanthocytosis and progressive neurological disturbances ( orofacial dyskinesia , limb chorea , lip and tongue biting , distal muscle wasting , muscle hypotonia , absent or diminished tendon reflexes ) with adult onset . | NA | {
"id": "C0393576",
"name": "ca",
"pos": [
0,
2
]
} | {
"id": "C0008489",
"name": "chorea",
"pos": [
159,
165
]
} |
pre- and postnatal protein deprivation was induced by a 50 % reduction in the dietary protein content . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
19,
26
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
78,
93
]
} |
the birth weight of the mothers , sibs , maternal aunts and their children were compared with those of 400 full-term , appropriate-for-gestational age , 181 true premature , 200 small-for-gestational age , and 261 correlation was found between the weight of the newborns and their mothers and maternal relatives in each case . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
4,
16
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
248,
254
]
} |
pulmonary edema is an important feature of many newborn lung diseases , including respiratory distress from severe perinatal asphyxia , heart failure , hyaline membrane disease , pneumonitis from group b beta-hemolytic streptococcus , and chronic lung disease ( bronchopulmonary dysplasia ) . | NA | {
"id": "C0034063",
"name": "pulmonary edema",
"pos": [
0,
15
]
} | {
"id": "C0024115",
"name": "of",
"pos": [
40,
42
]
} |
bacteremia , endotoxemia , and prolonged oxygen breathing injure the pulmonary microvascular endothelium and cause protein-rich fluid to accumulate in the lungs . | NA | {
"id": "C0004610",
"name": "bacteremia",
"pos": [
0,
10
]
} | {
"id": "C0376618",
"name": "endotoxemia",
"pos": [
13,
24
]
} |
electrophoresis demonstrated , besides ck-mm , an atypical , cathodically migrating ck band in 10 of these patients . | NA | {
"id": "C0010291",
"name": "ck-mm",
"pos": [
39,
44
]
} | {
"id": "C0010287",
"name": "ck",
"pos": [
84,
86
]
} |
isopropylaminophenazone was as active as acetylsalicylic acid while aminophenazone and methylaminophenazone , the major metabolites of metamizole , were about 10 times and phenazone 100 times less potent than acetylsalicylic acid . | NA | {
"id": "C0002586",
"name": "aminophenazone",
"pos": [
9,
23
]
} | {
"id": "C0012586",
"name": "metamizole",
"pos": [
135,
145
]
} |
sonography gives a prompt diagnosis of hydronephrosis , and needle puncture of the kidney yields pus and establishes the presence of pyonephrosis . | NA | {
"id": "C0020295",
"name": "hydronephrosis",
"pos": [
39,
53
]
} | {
"id": "C0034216",
"name": "pyonephrosis",
"pos": [
133,
145
]
} |
arrhythmias that may be due to disorders of impulse formation include slow atrial , junctional , and ventricular escape rhythms , certain types of atrial tachycardias ( such as those produced by digitalis ) , accelerated junctional ( nonparoxysmal junctional tachycardia ) and idioventricular rhythms , and parasystole . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
0,
11
]
} | {
"id": "C0206068",
"name": "parasystole",
"pos": [
307,
318
]
} |
arrhythmias that may be due to disorders of impulse conduction include flutter and fibrillation , atrioventricular nodal reentrant tachycardia , reciprocating tachycardias associated with an accessory pathway , sinus nodal reentry , some atrial tachycardias , and many ventricular tachycardias . | NA | {
"id": "C0039231",
"name": "tachycardias",
"pos": [
159,
171
]
} | {
"id": "C0042514",
"name": "ventricular tachycardias",
"pos": [
269,
293
]
} |
amiodarone , an iodinated benzofuran derivative , has electrophysiologic effects on cardiac muscle akin to those of hypothyroidism . | NA | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
0,
10
]
} | {
"id": "C0005068",
"name": "benzofuran",
"pos": [
26,
36
]
} |
seventy-four of 121 patients ( 61.2 % ) had no evidence of organic heart disease , whereas 17 patients experienced arrhythmia as a result of coronary heart disease , nine had preexcitation syndromes , 16 had primary valvular heart disease , and five patients , had congenital heart disease . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
115,
125
]
} | {
"id": "C0018799",
"name": "of",
"pos": [
138,
140
]
} |
seventy-four of 121 patients ( 61.2 % ) had no evidence of organic heart disease , whereas 17 patients experienced arrhythmia as a result of coronary heart disease , nine had preexcitation syndromes , 16 had primary valvular heart disease , and five patients , had congenital heart disease . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
115,
125
]
} | {
"id": "C0032915",
"name": "preexcitation syndromes",
"pos": [
175,
198
]
} |
in wolff-parkinson-white ( wpw ) syndrome , the two most commonly occurring arrhythmias are circus movement tachycardia ( cmt ) and atrial fibrillation ( af ) . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
76,
87
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
132,
151
]
} |
this agent appears to have a marked effect on the kinetics of some commonly used cardiovascular drugs , such as warfarin , digoxin , quinidine , and procainamide , and has dynamic interactions with others , such as the beta blockers and some calcium antagonists . | NA | {
"id": "C0007220",
"name": "cardiovascular drugs",
"pos": [
81,
101
]
} | {
"id": "C0006684",
"name": "calcium antagonists",
"pos": [
242,
261
]
} |
arrhythmias may be controlled in most patients with recurrent supraventricular tachycardia or atrial fibrillation with small to moderate maintenance doses of amiodarone ( 100 to 400 mg/day ) . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
0,
11
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
94,
113
]
} |
treatment and prevention of sustained recurrent vt and the malignant arrhythmias of chagasic myocarditis require , however , doses of about 800 mg/day , which may be higher than those needed for ischemic heart disease complicated by vt and ventricular fibrillation . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
69,
80
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
240,
264
]
} |
since the normal grain mycoflora usually contain mycotoxin-producing fungi , these toxins could be natural contaminants of grain dust . | NA | {
"id": "C0026955",
"name": "mycotoxin",
"pos": [
49,
58
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
83,
89
]
} |
the high-density lipoproteins ( hdl ) are the smallest of the plasma lipoprotein families and are approximately one half lipid and one half protein by weight . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
17,
28
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
121,
126
]
} |
the major lipid constituent of hdl is phosphatidylcholine , with sphingomyelin second , followed by cholesterol and cholesteryl ester . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
100,
111
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
116,
133
]
} |
the transfer of a fatty acid moiety from phosphatidylcholine to cholesterol provides a core of cholesteryl ester for hdl and facilitates formation of a stable spherical particle . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
64,
75
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
95,
112
]
} |
the deficient subjects had fasting normoglycemia with hypoinsulinemia ( p less than 0.01 ) , and a normal postglucose increment in insulin , but peak blood glucose and incremental glucose area were both significantly lower than in the controls ( p less than 0.01 ) . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
150,
163
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
180,
187
]
} |
clinicians usually overestimated the age of younger children and underestimated the age of older children ; | NA | {
"id": "C0728836",
"name": "of younger children",
"pos": [
41,
60
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
97,
105
]
} |
the isolates of staphylococcus aureus obtained at the onset of her disease had a 29/52 bacteriophage lysis pattern and produced enterotoxins c and f and epidermal toxin , but no exfolliatins . | NA | {
"id": "C0014372",
"name": "enterotoxins",
"pos": [
128,
140
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
163,
168
]
} |
in a second set of experiments that simulated the worst conditions expected in practice , mpss solutions of various concentrations having a ph of 7.8 and an initial free methylprednisolone percentage of 6 % were examined periodically for 24 hours for turbidity . | NA | {
"id": "C0700546",
"name": "mpss",
"pos": [
90,
94
]
} | {
"id": "C0025815",
"name": "methylprednisolone",
"pos": [
170,
188
]
} |
cures were effected in 35 ( 92 percent ) of 38 patients treated with amdinocillin and a beta-lactam antibiotic , compared with 37 ( 93 percent ) of 40 patients who were treated with an aminoglycoside/beta-lactam combination . | NA | {
"id": "C0026458",
"name": "beta-lactam antibiotic",
"pos": [
88,
110
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
200,
211
]
} |
ad hoc combinations of amdinocillin with ampicillin , ticarcillin , piperacillin , azlocillin , cefazolin , cefamandole , cefoxitin , and moxalactam in ratios similar to those in serum after parenteral administration of normal dosages of these agents were tested in vitro against over 200 strains of bacteria , including staphylococcus aureus , streptococcus faecalis , representative genera of the enterobacteriaceae , and pseudomonas aeruginosa . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
41,
51
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
68,
80
]
} |
ad hoc combinations of amdinocillin with ampicillin , ticarcillin , piperacillin , azlocillin , cefazolin , cefamandole , cefoxitin , and moxalactam in ratios similar to those in serum after parenteral administration of normal dosages of these agents were tested in vitro against over 200 strains of bacteria , including staphylococcus aureus , streptococcus faecalis , representative genera of the enterobacteriaceae , and pseudomonas aeruginosa . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
41,
51
]
} | {
"id": "C0004499",
"name": "azlocillin",
"pos": [
83,
93
]
} |
the electrocardiograms of 18 patients with atypical ventricular tachycardia manifested as torsade de pointes , ventricular fibrillo-flutter , polymorphous ventricular tachycardia , and uniform ventricular tachycardia were analyzed . | NA | {
"id": "C0040479",
"name": "torsade de pointes",
"pos": [
90,
108
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
193,
216
]
} |
it is suggested that qrs morphology during the tachycardia is not sufficient to distinguish between delayed repolarization and other causes of atypical ventricular tachycardia . | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
47,
58
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
152,
175
]
} |
among the autopsy subjects , comparing 35 nontransmural and 35 transmural infarcts , there was no significant difference with regard to subjects ' race or sex , chest pain , arrhythmias , heart block , or cause of death ; | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
174,
185
]
} | {
"id": "C0018794",
"name": "heart block",
"pos": [
188,
199
]
} |
long-term exposure to heavy metals , including lead , cadmium , arsenic , and mercury , can be readily identified by hair analysis . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
22,
34
]
} | {
"id": "C0023175",
"name": "lead",
"pos": [
47,
51
]
} |
long-term exposure to heavy metals , including lead , cadmium , arsenic , and mercury , can be readily identified by hair analysis . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
22,
34
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
54,
61
]
} |
long-term exposure to heavy metals , including lead , cadmium , arsenic , and mercury , can be readily identified by hair analysis . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
22,
34
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
78,
85
]
} |
the resolution of the paraneoplastic syndrome in this patient without the addition of cranial irradiation suggests that a trial of cytoreductive therapy is warranted in patients with limbic encephalopathy associated with an underlying neoplasm . | NA | {
"id": "C0030472",
"name": "paraneoplastic syndrome",
"pos": [
22,
45
]
} | {
"id": "C0027651",
"name": "neoplasm",
"pos": [
235,
243
]
} |
apolipoprotein a-i , a major protein constituent of chylomicrons and high-density lipoproteins , has been shown to be structurally and metabolically abnormal in this disease ( apolipoprotein a-itangier ) . | NA | {
"id": "C0085201",
"name": "apolipoprotein a-i",
"pos": [
0,
18
]
} | {
"id": "C0003592",
"name": "apolipoprotein a",
"pos": [
176,
192
]
} |
as a group , the eight patients showed acth-stimulated increments in testosterone , delta 4-androstenedione , dehydroepiandrosterone , and 17-ketosteroids that were significantly greater ( p less than 0.01 ) than the mean responses in the control group . | NA | {
"id": "C0002860",
"name": "delta 4-androstenedione",
"pos": [
84,
107
]
} | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
139,
154
]
} |
subhourly variability of circulating norepinephrine and epinephrine in the pregnant ewe and fetal and newborn lamb . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
37,
51
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
56,
67
]
} |
circulating norepinephrine and epinephrine were determined nine times over a 1-hour period in chronically instrumented ewes ( n = 4 ) , their fetuses ( n = 4 ) , and lambs ( n = 4 ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
12,
26
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
31,
42
]
} |
in an apparent resting state , assessed by subjective and biophysical parameters , marked fluctuations were demonstrated in the mean norepinephrine and epinephrine values between animals and in the range of the concentrations of each individual animal . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
133,
147
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
152,
163
]
} |
3 ) and the catabolic rate of hdl aposaa may be determined , in part , by its lipoprotein origin ( chylomicrons versus hdl ) . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
78,
89
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
99,
111
]
} |
the following striking modifications were observed in rats bearing pc 12 tumors : strong vasodilation , increase in protein and phospholipid percentage , alteration of the fatty acid composition of phospholipids , increase in mitochondrial protein , large increase of the gdp binding to isolated mitochondria , and marked rise in specific amount of 32,000-dalton uncoupling protein ( ascertained using immunological approach ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
116,
123
]
} | {
"id": "C0949610",
"name": "mitochondrial protein",
"pos": [
226,
247
]
} |
the brain uptake of [ 1-14c ] propionate was significantly reduced by keto acids and ketone bodies and the transport of d-3- [ 3-14c ] hydroxybutyrate was significantly inhibited by unlabeled monocarboxylic acids , keto acids , and acetoacetate . | NA | {
"id": "C0022618",
"name": "keto acids",
"pos": [
70,
80
]
} | {
"id": "C0000988",
"name": "acetoacetate",
"pos": [
232,
244
]
} |
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