text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
msg treatment resulted in a significant reduction in medial basal hypothalamic ( mbh ) da levels , no change in its norepinephrine ( ne ) and epinephrine ( e ) concentrations , and a marked increase in circulating prolactin ( prl ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
116,
130
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
142,
153
]
} |
the results confirm that protein hydrolysates are weak stimulants of pancreatic secretion in the rat compared with intact proteins and support the view that intact proteins and trypsin inhibitors stimulate pancreatic secretion in the rat by a common mechanism , i.e. , by reducing feedback inhibition from luminal pancreatic proteases . | NA | {
"id": "C0033631",
"name": "protein hydrolysates",
"pos": [
25,
45
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
164,
172
]
} |
the na+-dependent amino acid l-alanine inhibited [ 14c ] taurocholate uptake in a nonlinear fashion ( ic50 , approximately 7 mm ) . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
18,
28
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
31,
38
]
} |
influence of circulating ne and epi on adipose tissue vascular resistance and lipolysis in humans . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
25,
27
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
32,
35
]
} |
the effects of circulating norepinephrine ( ne ) and epinephrine ( epi ) on vascular resistance in subcutaneous adipose tissue and the calf as well as on plasma glycerol , an indicator of lipolysis , were studied in healthy volunteers . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
27,
41
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
53,
64
]
} |
furthermore , epi is a considerably more potent lipolytic hormone than ne in humans but not in the dog . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
14,
17
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
71,
73
]
} |
our results indicate that both ne and epi may influence human adipose tissue blood flow and lipolysis as circulating hormones . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
31,
33
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
38,
41
]
} |
immunoreactive pge2 and kallikrein were measured in the urine of conscious dogs during periods of water deprivation and periods of free access to drinking water and in the urine of time-control dogs that had free access to water throughout the study . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
146,
160
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
223,
228
]
} |
scatchard analysis to determine the equilibrium dissociation constant ( kd ) and the maximum number of binding sites ( bmax ) for control brown fat membranes gave a kd of 4.45 nm [ 3h ] dha and bmax of 249 fmol [ 3h ] dha bound per milligram of protein . beta-adrenergic agonists competed for specific binding sites with an order of potency typical of the beta 1 subtype of adrenergic receptors : ( - ) -isoproterenol greater than ( - ) -norepinephrine greater than or equal to ( - ) -epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
438,
452
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
485,
496
]
} |
in addition the kinetic behavior of products such as free fatty acids formed during hydrolysis of labeled tg fatty acids and liver tg derived from labeled circulating remnants was considered . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
53,
69
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
109,
120
]
} |
in children under age three anicteric infection was at least 17 times more frequent than icteric infection , but in older children and adults icterus was a predominant manifestation of the disease . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
3,
11
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
116,
130
]
} |
the differential diagnosis of this unusual tumor includes myxoma , myxoid liposarcoma , sarcoma botryoides , myxoid variant of malignant fibrous histiocytoma , nerve sheath myxoma , and other soft tissue tumors with secondary myxoid changes . | NA | {
"id": "C0027149",
"name": "myxoma",
"pos": [
58,
64
]
} | {
"id": "C0206730",
"name": "nerve sheath myxoma",
"pos": [
160,
179
]
} |
despite an initial decrease in the size of the lung metastases and concomitant lowering of the serum values of human chorionic gonadotropin ( beta-hcg ) from 2,200 to 40 ng/ml , combined chemotherapy became ineffective . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotropin",
"pos": [
111,
139
]
} | {
"id": "C0106132",
"name": "beta-hcg",
"pos": [
142,
150
]
} |
a 13-year-old female with biochemically proven alpha mannosidase deficiency ( mannosidosis ) developed a bilateral destructive synovitis of the ankle region , a hitherto unreported complication of this disease . | NA | {
"id": "C0024748",
"name": "alpha mannosidase deficiency",
"pos": [
47,
75
]
} | {
"id": "C1257960",
"name": "mannosidosis",
"pos": [
78,
90
]
} |
[ alpha fetoprotein , trophoblastic beta globulin and alpha 2g globulin levels in the mother-fetus system in prolonged pregnancy ] . | NA | {
"id": "C0002210",
"name": "alpha fetoprotein",
"pos": [
2,
19
]
} | {
"id": "C0002211",
"name": "alpha",
"pos": [
54,
59
]
} |
the occurrence of neuroblastoma , tuberous sclerosis , and astrocytoma is unique , and supports the suggested relationship between neural crest tumors and hamartoma syndromes . | NA | {
"id": "C0041341",
"name": "tuberous sclerosis",
"pos": [
34,
52
]
} | {
"id": "C0018552",
"name": "hamartoma",
"pos": [
155,
164
]
} |
in summary , it can be stated that all effects after alfentanil are similar to those of fentanyl . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
53,
63
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
88,
96
]
} |
pca was detected as the 4-nitrophenacyl ester which has an absorption maximum at 263 nm , a relatively high stability , and excellent chromatographic separation and detectability . | NA | {
"id": "C0007066",
"name": "pca",
"pos": [
0,
3
]
} | {
"id": "C0014898",
"name": "ester",
"pos": [
40,
45
]
} |
simple assays have been developed for the two uronosyl 5-epimerases which participate in the biosynthesis of heparin and dermatan sulfate ( heparosan n-sulfate d-glucuronosyl 5-epimerase and chondroitin d-glucuronosyl 5-epimerase , respectively ) . | NA | {
"id": "C0011602",
"name": "dermatan sulfate",
"pos": [
121,
137
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
191,
202
]
} |
this simple procedure is applicable to the analysis of these macromolecules in fibroblast cultures containing small numbers of cells ( less than 1 x 10 ( 5 ] . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
79,
89
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
127,
132
]
} |
this coupling reaction permitted the rapid purification of isoacceptor trnas of escherichia coli for the alpha-amino acids glycine , valine , and arginine , as well as the alpha-imino acid proline . | NA | {
"id": "C0020931",
"name": "imino",
"pos": [
178,
183
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
189,
196
]
} |
nucleic acids , both dna and rna , separated on agarose gels can be visualized by direct hybridization of the dried gel with appropriate radioactive probes . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
0,
13
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
21,
24
]
} |
application of periodate to monitoring of carbohydrates in effluents from borate anion-exchange columns is described . | NA | {
"id": "C0006007",
"name": "borate",
"pos": [
74,
80
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
81,
86
]
} |
in this paper , we report the viable sorting of late-passage cultures of human diploid fibroblasts ( imr-90 ) into two subpopulations of cells with different proliferative potentials . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
87,
98
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
137,
142
]
} |
in a randomized double-blind study , 40 orthopedic patients received one of the following four local anesthetics epidurally : 0.5 % bupivacaine-hcl ( n = 10 ) , 0.5 % bupivacaine-co2 ( n = 10 ) , 1.0 % etidocaine ( n = 10 ) , and 1.5 % etidocaine ( n = 10 ) , all without addition of a vasoconstrictor . | NA | {
"id": "C0887621",
"name": "bupivacaine-hcl",
"pos": [
132,
147
]
} | {
"id": "C0006400",
"name": "bupivacaine",
"pos": [
167,
178
]
} |
a spanish merino sheep population is characterized , for the first time , according to its frequencies for a total of nine polymorphic loci : three blood group factor systems , a , b and c , and the following red cell or serum polymorphisms : haemoglobin ( hb ) , carbonic anhydrase ( ca ) , ' x protein ' , transferrin ( tf ) , arylesterase ( esa ) and albumin ( al ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
296,
303
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
354,
361
]
} |
we compared the effect of inhaled terbutaline sulphate ( 1,000 micrograms ) , cromolyn sodium ( 20 mg ) , terbutaline plus cromolyn , and placebo on the response to respiratory heat loss ( rhl ) in 10 asthmatics in whom terbutaline alone did not completely inhibit the response to rhl . | NA | {
"id": "C0012694",
"name": "cromolyn sodium",
"pos": [
78,
93
]
} | {
"id": "C0086073",
"name": "cromolyn",
"pos": [
123,
131
]
} |
to determine if these pollutants produce airway responses , 17 asthmatics inhaled the following sulfates : sodium bisulfate , ammonium sulfate , ammonium bisulfate ( nh4hso4 ) , or sulfuric acid ( h2so4 ) aerosols with an aerodynamic diameter of 0.80 micron at concentrations of 100 micrograms/m3 , 450 micrograms/m3 , and 1,000 micrograms/m3 . | NA | {
"id": "C0038720",
"name": "sulfates",
"pos": [
96,
104
]
} | {
"id": "C0002620",
"name": "ammonium sulfate",
"pos": [
126,
142
]
} |
patient-controlled analgesia is used to treat postoperative and labor pain and pain associated with terminal illness ; | NA | {
"id": "C0474368",
"name": "labor pain",
"pos": [
64,
74
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
79,
83
]
} |
[ retrospective study of 290 cases of hyperthyroidism after 55 years of age without previously documented thyroid disorders ] . | NA | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
38,
53
]
} | {
"id": "C0040128",
"name": "thyroid disorders",
"pos": [
106,
123
]
} |
previous studies having shown differences in the clinical presentation of hyperthyroidism in the young and in the over sixty-years old patients , we studied the presentation of hyperthyroidism of late onset without previous thyroid disorder to determine if it continued to change with age after 55 years . | NA | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
74,
89
]
} | {
"id": "C0040128",
"name": "thyroid disorder",
"pos": [
224,
240
]
} |
a double blind comparison was made between alfentanil and fentanyl as analgesic components of anaesthesia . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
43,
53
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
58,
66
]
} |
sixty-six women undergoing laparoscopy received methohexitone , alcuronium , nitrous oxide and oxygen , with either alfentanil 0.75 mg or fentanyl 0.25 mg . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
116,
126
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
138,
146
]
} |
ten of the patients who received alfentanil and 1 patient who received fentanyl required supplementation of anaesthesia by enflurane . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
33,
43
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
71,
79
]
} |
the injection of fentanyl was followed by a fall in bp ( p less than 0.05 ) and the mean minimum value for pulse rate occurring after fentanyl was slower than after alfentanil ( p less than 0.05 ) . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
17,
25
]
} | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
165,
175
]
} |
strain e. coli k12 that had acquired k88 virulence factor possibly with other plasmid-coded characteristics but not the ability to produce st toxin was non-pathogenic . | NA | {
"id": "C1136170",
"name": "virulence factor",
"pos": [
41,
57
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
142,
147
]
} |
the typical rheumatoid foot deformity is that of hallux valgus , bunion , hammer claw toes with contracted dorsal soft tissue , depressed metatarsal heads and associated painful callosities and corns both under metatarsal heads and on dorsal surfaces of cocked-up lesser toes . | NA | {
"id": "C0016506",
"name": "foot deformity",
"pos": [
23,
37
]
} | {
"id": "C0018536",
"name": "hallux valgus",
"pos": [
49,
62
]
} |
pituitary gonadotropins and prolactin were measured from day 1 ( g1 ) to day 4 ( g4 ) of gestation in control or chlorpromazine injected rats ( img/100 g body weight every 8 hours during 72 hours ) . | NA | {
"id": "C0018066",
"name": "pituitary gonadotropins",
"pos": [
0,
23
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
28,
37
]
} |
chlorpromazine induced a modification of pituitary gonadotropins and prolactin ( decrease in lh from g1 to g4 ; decrease in fsh from g1 to g3 ; increase in prl from g1 to g4 ) . | NA | {
"id": "C0018066",
"name": "pituitary gonadotropins",
"pos": [
41,
64
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
69,
78
]
} |
differed implantation by chlorpromazine seemed to be due to a decrease in pituitary gonadotropins and an increase in pituitary prolactin . | NA | {
"id": "C0018066",
"name": "pituitary gonadotropins",
"pos": [
74,
97
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
127,
136
]
} |
for the patients with the relatively high age at death little or no difference is observed from the age at death of their non-affected parents and non-affected sibs . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
49,
54
]
} | {
"id": "C0524342",
"name": "death of",
"pos": [
107,
115
]
} |
protein h ( glial fibrillary acidic protein ) is synthesized at detectable levels by all messenger ribonucleic acid isolates , and the levels of its translatable messenger ribonucleic acid are reproducibly increased in ribonucleic acids isolated from cerebellar cortex of patients with joseph disease as compared with those isolated from cerebellar cortex of control subjects . | NA | {
"id": "C0035696",
"name": "messenger ribonucleic acid",
"pos": [
89,
115
]
} | {
"id": "C0035668",
"name": "ribonucleic acids",
"pos": [
219,
236
]
} |
this product is further converted to leukotrienes by elimination of the 10-pro-r hydrogen and oh from the hydroperoxy group to give 5,6-oxido-7,9,11 , 14-eicosatetraenoic acid ( leukotriene a4 ) . | NA | {
"id": "C0023545",
"name": "leukotrienes",
"pos": [
37,
49
]
} | {
"id": "C0125631",
"name": "leukotriene a4",
"pos": [
178,
192
]
} |
one strain , chosen for further study , was resistant to synergism between penicillin and gentamicin , tobramycin , kanamycin , streptomycin , and amikacin and demonstrated the following enzymatic activities : 3'- and 2 '' '' -aminoglycoside phosphotransferases , 6'-aminoglycoside acetyltransferase , and adenylylation of streptomycin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
116,
125
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
147,
155
]
} |
the effects of ubiquinone depletion in an e. coli strain were more evident on gentamicin uptake than on atp-driven glutamine transport or proton motive force-driven proline transport , consistent with a specific requirement for quinones in aminoglycoside uptake . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
78,
88
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
240,
254
]
} |
( e ) -5- ( 2-bromovinyl ) -2'-deoxyuridine ( bvdu ) was phosphorylated by the bovine herpesvirus 1 ( bhv-1 ) -induced thymidine kinase and subsequently incorporated into viral dna , resulting in dna that was more dense than dna from untreated cells . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
171,
180
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
225,
228
]
} |
besides t-2 toxin , trichothecenes such as diacetoxyscirpenol , neosolaniol , nivalenol , and fusarenon-x were also assimilated by this bacterium . | NA | {
"id": "C0039185",
"name": "t-2 toxin",
"pos": [
8,
17
]
} | {
"id": "C0040952",
"name": "trichothecenes",
"pos": [
20,
34
]
} |
the anaerobic degradation of polyethylene glycol ( molecular weight , 20,000 ) may be important in the light of the general resistance of polyethylene glycols to aerobic degradation . | NA | {
"id": "C0032483",
"name": "polyethylene",
"pos": [
29,
41
]
} | {
"id": "C0032478",
"name": "polyethylene glycols",
"pos": [
138,
158
]
} |
rabbit antiserum to the purified protease gave precipitin bands with antigens ( proteases ) from 10 different isolates . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
33,
41
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
80,
89
]
} |
the stimulatory effects of catecholamines occurred with the following order of potency : isoproterenol greater than epinephrine greater than norepinephrine . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
27,
41
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
89,
102
]
} |
the stimulatory effects of catecholamines occurred with the following order of potency : isoproterenol greater than epinephrine greater than norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
116,
127
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
141,
155
]
} |
furthermore , activation of phosphorylase in these hepatocytes by isoproterenol , epinephrine , and norepinephrine also occurred with the potency order expected for beta 2-receptors . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
82,
93
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
100,
114
]
} |
the uterine proenzyme is unusually rich in glycine and in the hydroxy amino acids and is considerably more acidic than the human skin fibroblast collagenase , consistent with the different ion-exchange behavior of the two molecules . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
43,
50
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
70,
81
]
} |
binding of l-malate and its dicarboxylic acid analogs oxalate and tartronate is abolished upon modification , as is binding of the monocarboxylic acid alpha-hydroxybutyrate . | NA | {
"id": "C0012063",
"name": "dicarboxylic",
"pos": [
28,
40
]
} | {
"id": "C0029988",
"name": "oxalate",
"pos": [
54,
61
]
} |
three other monoclonal antibodies were found to bind the purified antigen at a site or sites different from the o1-95-45 epitope and one other monoclonal antibody may bind at the same site . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
66,
73
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
121,
128
]
} |
augmented resistance was ascribed to a plastic dish-nonadherent , nylon wool column-nonadherent and thy 1.2-positive cells . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
39,
46
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
66,
71
]
} |
coadministration of tegafur and cytochrome c produced higher concentration of an active substance , 5-fu , in the blood of normal rats as compared with tegafur alone . | NA | {
"id": "C0016360",
"name": "5-fu",
"pos": [
100,
104
]
} | {
"id": "C0016778",
"name": "tegafur",
"pos": [
152,
159
]
} |
blood and tumor levels of 5-fu in tumor-bearing rats were higher in the combination than tegafur alone , and survival effects were more favorable in the former . | NA | {
"id": "C0016360",
"name": "fu",
"pos": [
28,
30
]
} | {
"id": "C0016778",
"name": "tegafur",
"pos": [
89,
96
]
} |
in the older children , 16 of 51 children with diarrhoea and 17 of 51 control children excreted this organism in their faeces . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
7,
21
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
78,
86
]
} |
the metabolism and excretion of paracetamol was studied in an infant of 29 weeks ' gestation who was exposed to the drug when his mother ingested 32.5 g 16 hours before delivery . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
4,
14
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
19,
28
]
} |
of 114 children with oesophageal atresia , 6 had cleft palate and other craniofacial anomalies present included cleft lip , micrognathia , hypertelorism , microcephaly , and hydrocephalus . | NA | {
"id": "C0376634",
"name": "craniofacial anomalies",
"pos": [
72,
94
]
} | {
"id": "C0025958",
"name": "microcephaly",
"pos": [
155,
167
]
} |
immune complexes of horseradish peroxidase oxidase ( hrp ) and rabbit igg antibodies to hrp were used to study the fc gamma-receptors in granulomas of cutaneous sarcoidosis . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
0,
16
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
74,
84
]
} |
using an immunoperoxidase ( skin biopsy ) and an immunofluorescence ( peripheral blood , bone marrow punctate ) technique , and monoclonal antibodies raised against peripheral mature lymphocytes , t helper subsets , t suppressor subsets , and langerhans cells , we found a predominant dermal infiltration with lymphocytes of the suppressor phenotype and a predominant epidermal infiltration with langerhans cells in a patient with sezary syndrome ( cutaneous t-cell lymphoma , ctcl ) . | NA | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
431,
446
]
} | {
"id": "C0079773",
"name": "ctcl",
"pos": [
477,
481
]
} |
guinea pigs were exposed by inhalation to atmospheric suspensions of crystalline free silica ( cristobalite ) , amorphous free silica ( diatomaceous earth ) , and amorphous silicate ( volcanic glass ) . | NA | {
"id": "C0037098",
"name": "silica",
"pos": [
86,
92
]
} | {
"id": "C0022683",
"name": "diatomaceous earth",
"pos": [
136,
154
]
} |
retrospective review of all of our cases of mctd confirms that liver disease is an uncommon occurrence in mctd . | NA | {
"id": "C0009782",
"name": "of",
"pos": [
21,
23
]
} | {
"id": "C0026272",
"name": "mctd",
"pos": [
106,
110
]
} |
isolated lipid a from strain sp 11 contains glucosamine , glucosamine-phosphate and the total of the fatty acids of the lipopolysaccharide . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
9,
16
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
120,
138
]
} |
red blood cell na+ , k+- , mg2+- , and ca2+-adenosine triphosphatase ( atpase ) activities were studied longitudinally in eight patients with affective disorders and 12 healthy volunteers . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
39,
42
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
71,
77
]
} |
levels of 5-hydroxyindoleacetic acid ( 5-hiaa ) , homovanillic acid ( hva ) , and 3-methoxy-4-hydroxyphenylglycol ( mhpg ) in the csf , and norepinephrine ( ne ) , epinephrine ( e ) , vanillylmandelic acid , normetanephrine , metanephrine , and mhpg in the urine , were measured in 151 hospitalized patients with affective disorders and in 80 healthy controls following a two-week drug-free period . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
140,
154
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
164,
175
]
} |
levels of 5-hydroxyindoleacetic acid ( 5-hiaa ) , homovanillic acid ( hva ) , and 3-methoxy-4-hydroxyphenylglycol ( mhpg ) in the csf , and norepinephrine ( ne ) , epinephrine ( e ) , vanillylmandelic acid , normetanephrine , metanephrine , and mhpg in the urine , were measured in 151 hospitalized patients with affective disorders and in 80 healthy controls following a two-week drug-free period . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
140,
154
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
208,
223
]
} |
levels of 5-hydroxyindoleacetic acid ( 5-hiaa ) , homovanillic acid ( hva ) , and 3-methoxy-4-hydroxyphenylglycol ( mhpg ) in the csf , and norepinephrine ( ne ) , epinephrine ( e ) , vanillylmandelic acid , normetanephrine , metanephrine , and mhpg in the urine , were measured in 151 hospitalized patients with affective disorders and in 80 healthy controls following a two-week drug-free period . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
143,
154
]
} | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
226,
238
]
} |
enzyme-antibody complex was isolated on a de-52 cellulose column and its electrophoretic mobility was different from that of the native enzyme . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
0,
6
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
136,
142
]
} |
the 1h-n.m.r . spectra of human somatotropin ( growth hormone ) show perturbed peaks from individual aromatic and aliphatic apolar residues , characteristic of a specifically folded globular structure . | NA | {
"id": "C0169964",
"name": "human somatotropin",
"pos": [
26,
44
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
47,
61
]
} |
the imidazole c-2-h resonance of histidine-151 is assigned , by comparison of its titration behaviour in human somatotropin and desamido-somatotropin ( asn-152 leads to asp-152 ) . | NA | {
"id": "C0169964",
"name": "human somatotropin",
"pos": [
105,
123
]
} | {
"id": "C0037663",
"name": "somatotropin",
"pos": [
137,
149
]
} |
these findings lead to the conclusion that of the two molecules of acetyl-coa that are bound by the enzyme and converted into acetoacetyl-coa , it is the one giving rise to c-3 and -4 that is bound initially to the enzyme in the form of the acetyl-enzyme intermediate complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
100,
106
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
248,
254
]
} |
a rabbit antibody against purified pig intestinal peroxidase was shown by means of western blotting and immunodetection to bind to peroxidases in various rat tissues , including eosinophils , uterus , uterine fluid and mammary tumours , and also to bind to bovine lactoperoxidase . | NA | {
"id": "C0027021",
"name": "peroxidase",
"pos": [
50,
60
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
131,
142
]
} |
a rabbit antibody against purified pig intestinal peroxidase was shown by means of western blotting and immunodetection to bind to peroxidases in various rat tissues , including eosinophils , uterus , uterine fluid and mammary tumours , and also to bind to bovine lactoperoxidase . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
131,
142
]
} | {
"id": "C0022948",
"name": "lactoperoxidase",
"pos": [
264,
279
]
} |
first , the possibility of proangiotensin or des-asp1-angiotensin being the pressor substance was ruled out by t.l.c . | NA | {
"id": "C0003017",
"name": "proangiotensin",
"pos": [
27,
41
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
54,
65
]
} |
since the reaction mixture was not contaminated with common proteolytic enzymes , such as trypsin , chymotrypsin , renin , cathepsin d and proangiotensin-converting enzyme , and other enzymes activated by kallikrein , it is clear that hog kallikrein directly produces angiotensin in vitro . | NA | {
"id": "C0003017",
"name": "proangiotensin",
"pos": [
139,
153
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
268,
279
]
} |
for fibrin formation , km is similar to that for fpa release , but , the conditions of the present study , vmax . was approximately half of that for fpa release . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
4,
10
]
} | {
"id": "C0016022",
"name": "fpa",
"pos": [
149,
152
]
} |
the formation of fibrin polymer before the sol-gel transition was studied by gel-permeation chromatography combined with effluent analysis for fibrinogen antigen and residual fpa . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
17,
23
]
} | {
"id": "C0016022",
"name": "fpa",
"pos": [
175,
178
]
} |
under these conditions , a single pyruvate dehydrogenase ( lipoamide ) dimer appeared able to cause a rapid ( 20s ) reductive acetylation of probably all 24 polypeptide chains in the dihydrolipoamide acetyltransferase core of the enzyme complex from e. coli at 37 degrees c , and of most if not all of the 60 polypeptide chains in the dihydrolipoamide acetyltransferase cores of the enzymes from ox heart and b. stearothermophilus at 37 degrees c and 60 degrees c respectively . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
230,
244
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
383,
390
]
} |
( enzyme-linked immunosorbent assay ) is described that enables direct measurement of the muscle-specific polypeptide of chick creatine kinase ( m-ck ) in extracts of differentiating muscle-cell cultures and in blood plasma samples , even in the presence of embryonic , or brain-type , creatine kinase . | NA | {
"id": "C0010291",
"name": "muscle",
"pos": [
90,
96
]
} | {
"id": "C0010287",
"name": "creatine",
"pos": [
286,
294
]
} |
the four major ecdysteroid ( insect moulting hormone ) conjugates present in the newly laid eggs of the desert locust , schistocera gregaria , have been purified by reversed-phase and anion-exchange high-performance liquid chromatography . | NA | {
"id": "C0058915",
"name": "ecdysteroid",
"pos": [
15,
26
]
} | {
"id": "C0013494",
"name": "moulting hormone",
"pos": [
36,
52
]
} |
indomethacin and meclofenamic acid , inhibitors of the enzyme cyclo-oxygenase , which converts free arachidonic acid into the prostaglandins , prostacyclins and thromboxanes , decreased the rate of protein synthesis in intermittently stretched muscles , but had no effect on synthesis rates in the unstimulated controls . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
126,
140
]
} | {
"id": "C0205911",
"name": "prostacyclins",
"pos": [
143,
156
]
} |
specific activity of phosphofructokinase is 7-8-fold higher in exponentially growing human fibroblasts than in quiescent cells , but the difference is considerably less pronounced for two other glycolytic enzymes , glucose phosphate isomerase and pyruvate kinase . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
91,
102
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
121,
126
]
} |
isethionate , an impermeant anionic replacement for chloride , blocks the release step but does not affect receptor recruitment . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
28,
35
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
52,
60
]
} |
the insensitivity of this atpase activity to univalent ions and inhibitors of pancreatic electrolyte secretion , taken together with the evidence that the active site is externally located , suggests that this enzyme is not directly involved in hco3- secretion in the pancreas . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
55,
59
]
} | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
89,
100
]
} |
the half-life of the receptor was slightly longer ( 32 h ) in i-cell disease fibroblasts and normal fibroblasts exposed to leupeptin ( 32 h ) , slightly shorter in fibroblasts exposed to nh4cl ( 23 h ) and saturating amounts of ligand ( 21 h ) and unaffected in cells exposed to mannose 6-phosphate ( 24 h ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
77,
88
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
262,
267
]
} |
both of these proteins contain exposed galactosyl residues , and were avidly bound by the lectin on the hepatic parenchymal cell surface . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
14,
22
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
90,
96
]
} |
measurement of rates of synthesis of skeletal-muscle proteins in adult rats shows that the faster overall rate of turnover in diaphragm and soleus muscles compared with several other , more glycolytic , muscles is also exhibited by the myofibrillar proteins , since the ratio of sarcoplasmic to myofibrillar protein synthesis is similar for all muscles . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
24,
33
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
249,
257
]
} |
this was a similar value to that in adult non-growing rats , in which measurements of the relative labelling of 3-methylhistidine and histidine after a single injection of [ 14c ] histidine indicated that 3-methylhistidine synthesis was 37 % of the overall rate in the fed or overnight-starved state . | NA | {
"id": "C0025780",
"name": "methylhistidine",
"pos": [
114,
129
]
} | {
"id": "C0019602",
"name": "histidine",
"pos": [
213,
222
]
} |
the rate of protein synthesis in muscle and liver and the rate of actomyosin synthesis in muscle were measured by the phenylalanine-flooding technique , and 3-methylhistidine ( n tau-methylhistidine ) synthesis was measured by injection of labelled histidine . | NA | {
"id": "C0025780",
"name": "methylhistidine",
"pos": [
159,
174
]
} | {
"id": "C0019602",
"name": "histidine",
"pos": [
249,
258
]
} |
this decrease in the overall rate was accompanied with changes in the relative rate of synthesis in muscle proteins , since during the first 4 days there was a disproportionate decrease in the rate of actomyosin synthesis , and specifically 3-methylhistidine synthesis . | NA | {
"id": "C0026832",
"name": "muscle proteins",
"pos": [
100,
115
]
} | {
"id": "C0001291",
"name": "actomyosin",
"pos": [
201,
211
]
} |
a group of 35-day-old rats treated with normal chow supplemented with 5 % phe + 0.4 % alpha-methylphenylalanine , alpha mp , for the previous 10 days showed decreases in dopa , norepinephrine , and epinephrine versus controls . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
177,
191
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
198,
209
]
} |
it is suggested that this enzyme , acting within a region of the molecule which is of major importance in stabilizing fibrillar collagen through intermolecular cross-linking , could potentially play an important role in collagen turnover in vivo . | NA | {
"id": "C0969669",
"name": "fibrillar collagen",
"pos": [
118,
136
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
220,
228
]
} |
we suggest that s100b protein should no longer be considered only as a `` '' calcium binding protein '' '' but also as a `` '' zinc binding protein '' '' , and that zn2+ ions are involved in the functions of the s100 proteins . | NA | {
"id": "C3658228",
"name": "s100b protein",
"pos": [
16,
29
]
} | {
"id": "C0027758",
"name": "the s100 prot",
"pos": [
208,
221
]
} |
to this , zinc , as zinc acetate , was re-added in a stepwise fashion to yield a series of complexes with ratios of metal to protein varying from 1:1 to 7:1 . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
10,
14
]
} | {
"id": "C0149368",
"name": "zinc acetate",
"pos": [
20,
32
]
} |
we have investigated the formal reduction potentials ( e degrees ' ) of adrenodoxin with and without adrenodoxin reductase in order to elucidate the mechanism of electron transfer from adrenodoxin reductase ( a flavoprotein ) to adrenodoxin ( an iron-sulfur protein ) . | NA | {
"id": "C0001657",
"name": "adrenodoxin",
"pos": [
72,
83
]
} | {
"id": "C0022095",
"name": "iron-sulfur protein",
"pos": [
246,
265
]
} |
removal of the stimulus induces deadaptation , which for both camp and folic acid has first order kinetics with a half-life of 1.5 min . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
98,
106
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
114,
123
]
} |
these results suggest that branched-chain amino acids , particularly leucine , may be important for the synthesis of glutamic acid by the brain . | NA | {
"id": "C0002521",
"name": "branched-chain amino",
"pos": [
27,
47
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
69,
76
]
} |
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