text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
no significant differences were found for any examined element ( sodium , phosphorus , sulfur , chlorine , potassium , magnesium and calcium ) . | NA | {
"id": "C0013879",
"name": "element",
"pos": [
55,
62
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
74,
84
]
} |
the antigenic determinant was found to involve an alpha-galactosyl residue , since alpha-galactosidase from coffee bean , but not other glycosidases abolished the antigenic activity of the large glycan isolated from f9 and ott6050 cells . | NA | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
4,
25
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
163,
172
]
} |
on the contrary , ouchterlony double diffusion analyses indicated that cytochrome p-450 isolated from tulip bulbs shares no common antigenic determinants with those of 9 other plants , in spite of the presence of comparable contents of cytochrome p-450 and/or trans-cinnamate 4-monooxygenase with tulip bulbs . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
71,
87
]
} | {
"id": "C0076897",
"name": "trans-cinnamate 4-monooxygenase",
"pos": [
260,
291
]
} |
glycerol-induced arf markedly reduced the renal excretion of [ 14c ] cp , the major route of elimination of the drug in control rats , but did not alter the plasma clearance of [ 14c ] cp . | NA | {
"id": "C1373187",
"name": "renal excretion",
"pos": [
42,
57
]
} | {
"id": "C1373186",
"name": "route of elimination",
"pos": [
84,
104
]
} |
these enzymes have the capacity to catalyze the deamination of 2,6-diamino-9- ( 2-hydroxyethoxymethyl ) purine ( a134u ) to form the antiviral agent acyclovir [ 9- ( 2-hydroxyethoxymethyl ) guanine ] . | NA | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
149,
158
]
} | {
"id": "C0018321",
"name": "guanine",
"pos": [
190,
197
]
} |
after elaboration of the optimum conditions , the metabolism of two concentrations of arachidonic acid ( aa ) was studied in the presence and absence of endotoxin lipopolysaccharide ( lps ) from e. coli o127 : b8 ( 0.1 and 1.0 mg/ml ) . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
153,
162
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
163,
181
]
} |
identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
35,
46
]
} | {
"id": "C0061516",
"name": "glutathione disulfide",
"pos": [
107,
128
]
} |
this was established using two specific enzymatic methods : ( a ) the coupled assay with dtnb and glutathione ( gssg ) reductase and ( b ) a newly developed test using gsh transferase and 1-chloro-2,4-dinitrobenzene for the estimation of gsh released from proteins after borohydride treatment ; | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
112,
116
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
238,
241
]
} |
the amount of glutathione mixed disulfides depends linearly on the content of glutathione disulfide in the liver cell in the range studied . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
14,
25
]
} | {
"id": "C0061516",
"name": "glutathione",
"pos": [
78,
89
]
} |
by increasing the gssg levels from 20 to about 60 nmole/g liver with paraquat , nitrofurantoin or t-butyl hydroperoxide , glutathione protein mixed disulfides are increased by a similar amount . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
18,
22
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
122,
133
]
} |
total folate levels in the urine peaked in both ethanol- and methanol-treated rats at the same time as the urine alcohol levels ( after 6-8 hr ) and then declined over the same time course as the alcohol levels . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
61,
69
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
196,
203
]
} |
unlike salicylic acid , an acidic compound only bound to human serum albumin , the basic drugs were bound to all plasma protein fractions studied ( albumin , alpha 1-acid glycoprotein , lipoproteins , gamma-globulins ) with alpha 1-acid glycoprotein an important binding protein for each of them . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
57,
76
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
148,
155
]
} |
the ld50 and ld0 of choline hcl and cytidine diphosphate choline ( cdp-choline , citicoline , somazina ) by oral and intravenous route at equivalent doses of choline for both compounds were determined . | NA | {
"id": "C0010725",
"name": "citicoline",
"pos": [
81,
91
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
158,
165
]
} |
the qualitative and quantitative analysis of the results obtained lead to the conclusion that choline shows a remarkable cholinergic action , while cdp-choline both orally and intravenously does not cause any cholinergic intoxication in the treated groups , like those recorded for choline administration . | NA | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
148,
159
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
282,
289
]
} |
it should be emphasized that when the quantity of choline contained in cdp-choline administered was identical to that of choline with which the animal group was treated showing signs of cholinergic crisis , the animals corresponding to cdp-choline did not show any of these symptoms . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
50,
57
]
} | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
236,
247
]
} |
objective evaluation showed that cdp-choline by oral and intravenous route does not behave like a choline groups donator , at least not with an intensity which would make us believe that its only action was due to the increased levels of choline ; | NA | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
33,
44
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
238,
245
]
} |
this proves that cdp-choline administration yields clearly differentiated metabolic consequences from those yielded by choline administration . | NA | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
17,
28
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
119,
126
]
} |
identification of some fractions as enriched in synaptosomes also accumulating radioactivity , as well as the possible incorporation of the radioactivity to choline and phosphorylcholine cerebral pools are discussed . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
157,
164
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
169,
186
]
} |
the absorption , metabolism and excretion of cytidine diphosphate choline ( cdp-choline , citicoline , somazina ) were investigated in six adult healthy subjects after a single oral dose of 300 mg of the 14c-labelled compound . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
17,
27
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
32,
41
]
} |
plasma adrenaline and noradrenaline concentrations were measured in 24 patients during the induction of anaesthesia and the subsequent tracheal intubation . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
7,
17
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
22,
35
]
} |
the role of carcinoembryonic antigen ( cea ) , gamma glutamyl transpeptidase ( gamma gt ) , phosphohexose isomerase ( phi ) , pseudouridine ( psi ) and acute phase reactant proteins ( c-reactive protein ( crp ) alpha 1-antichymotrypsin ( act ) and alpha 1-acid glycoprotein ( agp ] in assessing the prognosis of gastrointestinal neoplasms and the discriminant function in distinguishing benign from malignant diseases of the gi tract was examined . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
152,
163
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
184,
202
]
} |
the role of carcinoembryonic antigen ( cea ) , gamma glutamyl transpeptidase ( gamma gt ) , phosphohexose isomerase ( phi ) , pseudouridine ( psi ) and acute phase reactant proteins ( c-reactive protein ( crp ) alpha 1-antichymotrypsin ( act ) and alpha 1-acid glycoprotein ( agp ] in assessing the prognosis of gastrointestinal neoplasms and the discriminant function in distinguishing benign from malignant diseases of the gi tract was examined . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
152,
163
]
} | {
"id": "C0002190",
"name": "alpha 1-antichymotrypsin",
"pos": [
211,
235
]
} |
the role of carcinoembryonic antigen ( cea ) , gamma glutamyl transpeptidase ( gamma gt ) , phosphohexose isomerase ( phi ) , pseudouridine ( psi ) and acute phase reactant proteins ( c-reactive protein ( crp ) alpha 1-antichymotrypsin ( act ) and alpha 1-acid glycoprotein ( agp ] in assessing the prognosis of gastrointestinal neoplasms and the discriminant function in distinguishing benign from malignant diseases of the gi tract was examined . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
152,
163
]
} | {
"id": "C0029297",
"name": "agp",
"pos": [
276,
279
]
} |
after stimulation with iron ( 8 mg/kg iron dextran i.v . ) , ferritin synthesis rose in both groups of animals . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
23,
27
]
} | {
"id": "C0022092",
"name": "iron dextran",
"pos": [
38,
50
]
} |
in addition , the interaction with m phi of both neuraminidase-treated and untreated ifle was found to be influenced by a heat-stable serum factor . gamma-globulin markedly enhanced the weak ifle-m phi interaction which occurred at low serum concentration suggesting that the heat-stable factor may be an immunoglobulin . | NA | {
"id": "C0017007",
"name": "gamma-globulin",
"pos": [
149,
163
]
} | {
"id": "C0021027",
"name": "immunoglobulin",
"pos": [
305,
319
]
} |
randomized cross-over studies were undertaken to determine the effects of daily dietary supplements of pectin ( 12 g/d ) , cellulose ( 15 g/d ) and lignin ( 12 g/d ) on stool characteristics of healthy volunteers . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
123,
132
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
148,
154
]
} |
amino acid oxidation by young pigs receiving diets with varying levels of sulphur amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0002527",
"name": "diets",
"pos": [
45,
50
]
} |
carotene cleavage may be effected by a copper-zinc metalloprotein of low-molecular weight , associated in intestinal cytosol with a lipid-protein aggregate . | NA | {
"id": "C0025544",
"name": "metalloprotein",
"pos": [
51,
65
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
138,
145
]
} |
phosphorus-31 nuclear magnetic resonance of ethidium complexes with ribonucleic acid model systems and phenylalanine-accepting transfer ribonucleic acid . | NA | {
"id": "C0035668",
"name": "ribonucleic",
"pos": [
68,
79
]
} | {
"id": "C0035711",
"name": "transfer ribonucleic acid",
"pos": [
127,
152
]
} |
the ( na+ and k+ ) -stimulated adenosinetriphosphatase [ ( na+ , k+ ) -atpase ] consists of two different polypeptides , alpha and beta , both of which are embedded in the plasma membrane . | NA | {
"id": "C0001473",
"name": "adenosinetriphosphatase",
"pos": [
31,
54
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
59,
61
]
} |
the rate and extent of redistribution of repair-incorporated nucleotides within chromatin during very early times ( 10-45 min ) after ultraviolet irradiation were examined in normal human fibroblasts treated with 20 mm sodium butyrate , or 2-10 mm hydroxyurea , and compared to results for untreated cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
188,
199
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
300,
305
]
} |
the secondary structure as reflected in the circular dichroic spectra is similar to that of holo-ldl2 when only lecithin is bound , but is significantly altered when cholesterol is also present in the complex , suggesting that the molecular organization of the ternary complex formed in the absence of neutral lipids is significantly different from that of the native lipoprotein . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
310,
316
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
368,
379
]
} |
the oxidase yields the red semiquinone form on dithionite or photochemical reduction , slowly forms an n-5 adduct with 0.16 m sulfite at ph 7.4 , and is rapidly reduced by borohydride , forming the 3,4-dihydroflavin isomer . | NA | {
"id": "C0012787",
"name": "dithionite",
"pos": [
47,
57
]
} | {
"id": "C0038750",
"name": "sulfite",
"pos": [
126,
133
]
} |
acyl-coa oxidase and the acyl-coa dehydrogenases share many similarities in their interaction with coa derivatives . | NA | {
"id": "C0050690",
"name": "acyl-coa",
"pos": [
0,
8
]
} | {
"id": "C0085744",
"name": "acyl-coa dehydrogenases",
"pos": [
25,
48
]
} |
however , the kinetic mechanism , the amount of chloride required , and the effect of ph on activation , plus the relative activating potencies of various anions , are all strongly dependent on the substrate employed . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
48,
56
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
155,
161
]
} |
its comparison with that of the cross-reactive hla-b7 antigen allows for the first time a direct sequence comparison between two hla-b locus products and an outline of the location of their alloantigenic sites . | NA | {
"id": "C0019744",
"name": "hla-b7 antigen",
"pos": [
47,
61
]
} | {
"id": "C0019737",
"name": "hla-b locus",
"pos": [
129,
140
]
} |
during these studies , it was discovered that the factor x which became activated to factor xa during the course of reaction participated in several feedback reactions : activation of factor x , activation of factor viii , and conversion of factor ixa alpha to factor ixa beta . | NA | {
"id": "C0015520",
"name": "factor xa",
"pos": [
85,
94
]
} | {
"id": "C0015518",
"name": "factor x",
"pos": [
184,
192
]
} |
the proton magnetic resonance spectrum at 300 mhz of the histidine residues in a semisynthetic derivative of bovine pancreatic ribonuclease ( rnase a ) has been determined . | NA | {
"id": "C0035541",
"name": "pancreatic ribonuclease",
"pos": [
116,
139
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
142,
147
]
} |
calcium-dependent inhibitory region of troponin : a proton nuclear magnetic resonance study on the interaction between troponin c and the synthetic peptide n alpha-acetyl [ fphe106 ] tni- ( 104-115 ) amide . | NA | {
"id": "C0041199",
"name": "troponin",
"pos": [
39,
47
]
} | {
"id": "C0077401",
"name": "tni",
"pos": [
183,
186
]
} |
a mechanism for the auto-oxidation of reduced phenazine derivatives is proposed where superoxide production occurs in discrete steps in the auto-oxidation of fully reduced pyocyanine whereas for the auto-oxidation of fully reduced phenazine methosulphate , phenazine ethosulphate and 1-methyoxyphenazine methosulphate , the production of superoxide appears masked by the rapid further reduction to hydrogen peroxide . | NA | {
"id": "C0031375",
"name": "phenazine",
"pos": [
46,
55
]
} | {
"id": "C0034211",
"name": "pyocyanine",
"pos": [
172,
182
]
} |
a mechanism for the auto-oxidation of reduced phenazine derivatives is proposed where superoxide production occurs in discrete steps in the auto-oxidation of fully reduced pyocyanine whereas for the auto-oxidation of fully reduced phenazine methosulphate , phenazine ethosulphate and 1-methyoxyphenazine methosulphate , the production of superoxide appears masked by the rapid further reduction to hydrogen peroxide . | NA | {
"id": "C0031375",
"name": "phenazine",
"pos": [
46,
55
]
} | {
"id": "C0025809",
"name": "phenazine methosulphate",
"pos": [
294,
317
]
} |
the permeability to the lipophilic solutes methanol , ethanol and antipyrine was not affected by any of these agents . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
43,
51
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
54,
61
]
} |
conversely , other domains , representing the bulk of the membrane lipids and which probably contain the relatively lower melting point lipids , undergo solidus phase formation at temperatures which reflect changes in the membrane lipid composition which are in turn , a reflection of the nature of the dietary lipid intake . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
67,
73
]
} | {
"id": "C0025249",
"name": "membrane lipid",
"pos": [
222,
236
]
} |
the method of kaderbhai and freedman ( biochim . biophys . acta 601 ( 1980 ) 21-20 ) gives good resolution of acidic proteins but excludes hydrophobic integral membrane proteins of pi greater than 7 , including cytochrome p-450 apoproteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
117,
125
]
} | {
"id": "C0003601",
"name": "apoproteins",
"pos": [
228,
239
]
} |
cytoplasmic creatine kinase ( atp : creatine n-phosphotransferase , ec 2.7.3.2 ) is a dimeric enzyme exhibiting three isoenzymes ( mm , mb and bb ) . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
94,
100
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
118,
128
]
} |
moreover , the good alignment of predicted beta-sheet segments in alpha-crystallin chains with known beta-sheet strands in gamma 2- ( and presumably beta bp- ) crystallin strongly supports a similar 4-motif folding pattern in all four calf crystallin chains . | NA | {
"id": "C0002257",
"name": "alpha-crystallin",
"pos": [
66,
82
]
} | {
"id": "C0010422",
"name": "crystallin",
"pos": [
240,
250
]
} |
we conclude that a site capable of accelerating the plasminogen activation by tissue-type plasminogen activator preexists in fibrinogen , that this site becomes exposed upon fibrin formation or disruption of fibrinogen by plasmin or cnbr and that this site is within the stretch a alpha 148-197 , which is retained in the a alpha-chain remnants of fibrinogen degradation products . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
125,
131
]
} | {
"id": "C0163275",
"name": "fibrinogen degradation products",
"pos": [
348,
379
]
} |
the ligand-binding characteristics of periplasmic galactose-binding protein and maltose-binding protein of escherichia coli are analyzed . | NA | {
"id": "C0031131",
"name": "ligand-binding",
"pos": [
4,
18
]
} | {
"id": "C2936473",
"name": "maltose-binding protein",
"pos": [
80,
103
]
} |
the rate of the microsomal acyl-coa : cholesterol acyltransferase and the concentration of microsomal cholesterol esters significantly increased more than 100 % in both cholesterol-fed and estradiol-injected rats . | NA | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
102,
120
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
169,
180
]
} |
the rate of biliary cholesterol output was reciprocally correlated with both microsomal cholesterol ester concentration of livers ( r = -0.47 , p less than 0.01 ) and the activity of the hepatic acyl-coa : cholesterol acyltransferase ( r = -0.58 , p less than 0.005 ) in a series of rats injected with progesterone , with progesterone +1 % cholesterol diet and with progesterone + estradiol . | NA | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
88,
105
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
340,
351
]
} |
lower molecular weight forms of apolipoprotein b ( b74 and b26 ) increased relative to apolipoprotein b100 with increasing density , ranging from undetectable in fraction 1 to apolipoproteins b26 and b74 comprising 30 % of the total mass of apolipoprotein b in fraction 6 . | NA | {
"id": "C0205666",
"name": "apolipoprotein b100",
"pos": [
87,
106
]
} | {
"id": "C0003593",
"name": "apolipoprotein b",
"pos": [
241,
257
]
} |
lower molecular weight forms of apolipoprotein b ( b74 and b26 ) increased relative to apolipoprotein b100 with increasing density , ranging from undetectable in fraction 1 to apolipoproteins b26 and b74 comprising 30 % of the total mass of apolipoprotein b in fraction 6 . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
176,
191
]
} | {
"id": "C0003593",
"name": "apolipoprotein b",
"pos": [
241,
257
]
} |
these results indicate that lysophosphatidic acid , synthesized by glycerophosphate acyltransferase , is utilized by 1-acylglycerophosphate acyltransferase without prior mixing with the total membrane-associated pool of lysophosphatidic acid , and suggest a close proximity of the two enzymes in native e. coli membranes . | NA | {
"id": "C0017874",
"name": "glycerophosphate acyltransferase",
"pos": [
67,
99
]
} | {
"id": "C0001390",
"name": "acyltransferase",
"pos": [
140,
155
]
} |
these effects appear to complement the known atp-dependent activation of adrenal cytosolic cholesterol ester hydrolase , which is consistent with the role of the hydrolase in supplying cholesterol for steroidogenesis . | NA | {
"id": "C0008387",
"name": "cholesterol",
"pos": [
91,
102
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
185,
196
]
} |
amino acid analysis indicated lack of cysteine and a high basic amino acid content typical of histones . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
58,
74
]
} |
the cellular glycoconjugate composition was normal , and pathologic fibroblasts labeled with either [ 3h ] glucosamine-hcl or n- [ 3h ] acetylmannosamine showed a marked accumulation of labeled free n-acetylneuraminic acid , along with elevated incorporation into sialoglycoconjugates . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
4,
12
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
68,
79
]
} |
these results imply that there is not a simple relationship between superoxide and hydrogen peroxide production and ascorbate oxidation , and that release of ascorbate into the phagolysosomes does not occur . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
68,
78
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
92,
100
]
} |
concentration of 1 ng/ml somatostatin-14 ( 0.625 nm ) and somatostatin-28 ( 0.312 nm ) was found to inhibit completely the glycerol release induced by concentrations of glucagon up to 2 ng/ml ( 0.58 nm ) . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
25,
40
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
58,
73
]
} |
the small inhibiting effect of somatostatin-14 on glycerol release prompted by dibutyryl cyclic amp , together with the significant inhibiting effect on aminophylline-stimulated lipolysis argued for a reduction of cyclic amp accumulation . | NA | {
"id": "C0012054",
"name": "dibutyryl",
"pos": [
79,
88
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
214,
224
]
} |
heat stability of 23s rrna in total rna is due to the presence in these preparations of a contaminant which appears to act as a chelator of polyvalent cations . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
22,
26
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
36,
39
]
} |
the amino acid composition of the h1-like histone isolated from carp spermatozoa ( h1carp ) is characterized by a high content of lysine ( 34.6 % ) and a low content of glycine ( 4.5 % ) as compared to that of its calf counterpart ( h1calf ) . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
169,
176
]
} |
[ the state of energy metabolism and lipid distribution in the livers of rats treated with phenobarbital and oil ] . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
37,
42
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
109,
112
]
} |
a rabbit antiserum to lmwk which is free of antibodies against igg and albumin present as admixtures in the kininogen preparation has been obtained . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
9,
18
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
44,
54
]
} |
the titer of the antiserum as measured by dilution of antibodies , with normal human blood plasma as an antigen source , is 1 : 16 . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
17,
26
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
54,
64
]
} |
small particles of co-cr-mo were phagocytosed by intimal cells , macrophages , multinucleate giant cells ( macrophage polykaryons ) and fibroblasts ; | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
57,
62
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
136,
147
]
} |
ocular inserts impregnated with antibiotics ( erythromycin and erythromycin estolate ) which have sustained release characteristics were prepared , mainly for the purpose of trachoma therapy . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
46,
58
]
} | {
"id": "C0014809",
"name": "erythromycin",
"pos": [
63,
75
]
} |
radioactive labeled protein and platelet studies suggest that an ideal vascular surface absorbs albumin and prevents platelet adherence and aggregation . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
20,
27
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
96,
103
]
} |
steady-state diffusion profiles of fluorescein sodium developed along the axis of the muscle in the physiological node by continuously perfusing the sucrose pool with 210-mm sucrose plus fluorescein ( 5-10 mm ) . | NA | {
"id": "C0147866",
"name": "fluorescein sodium",
"pos": [
35,
53
]
} | {
"id": "C0060520",
"name": "fluorescein",
"pos": [
187,
198
]
} |
nmr evidence of the relation between sugar ring and c3 ' -- o3 ' bond conformational properties of oligo- and polynucleotides in solution . | NA | {
"id": "C0028953",
"name": "oligo",
"pos": [
99,
104
]
} | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
110,
125
]
} |
the most abundant ion in the negative ion spectra corresponded to the loss of the alkali metal cation to give [ m ] - . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
18,
21
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
95,
101
]
} |
this metabolic state was accompanied by hyperinsulinism both in vivo and in vitro , suggesting that a state of insulin resistance has developed . | NA | {
"id": "C0020459",
"name": "hyperinsulinism",
"pos": [
40,
55
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
111,
129
]
} |
a hypothesis of the use of hemopoietic stem cells with a view of satisfying the demand for mature cells depending on their generation age predicts that cfus that survived after repeated treatment with hydroxyurea should have a greater capacity for self-renewal . | NA | {
"id": "C0018956",
"name": "hemopoietic stem cells",
"pos": [
27,
49
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
117,
120
]
} |
blood circulation and gas exchange were examined after replacement of blood loss ( 50 ml/kg bw ) in dogs by a preparation containing perfluorocompound ( pfc ) emulsion ( 20 v. % ) and protein-salt solution ( pss ) consisting of isotonic solution of electrolytes and donor 's albumin , the final concentration of the latter in the preparation being equal to 5 % . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
184,
191
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
275,
282
]
} |
to characterize the extraneuronal accumulation of catecholamines ( ca ) in the media of rabbit aorta pieces of isolated media were incubated with 3h-ca ( norepinephrine , isoproterenol or normetanephrine ) plus 14c-sorbitol ( to estimate the extracellular space ) for varying periods at 37 or 0 degree c . | NA | {
"id": "C0007412",
"name": "ca",
"pos": [
50,
52
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
171,
184
]
} |
to characterize the extraneuronal accumulation of catecholamines ( ca ) in the media of rabbit aorta pieces of isolated media were incubated with 3h-ca ( norepinephrine , isoproterenol or normetanephrine ) plus 14c-sorbitol ( to estimate the extracellular space ) for varying periods at 37 or 0 degree c . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
154,
168
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
188,
203
]
} |
ceruloplasmin ( cp ) , an acute phase reactant , has been found to be elevated in patients with various tumors including breast cancer . | NA | {
"id": "C0007841",
"name": "ceruloplasmin",
"pos": [
0,
13
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
26,
46
]
} |
a total of 47 different cannabinoids were successfully separated and 5 of these , cannabinol , cannabidiol , cannabichromene , trans-delta-8-tetrahydrocannabinol and delta-9-tetrahydrocannabinol , were identified . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
24,
36
]
} | {
"id": "C0006865",
"name": "cannabinol",
"pos": [
184,
194
]
} |
a total of 47 different cannabinoids were successfully separated and 5 of these , cannabinol , cannabidiol , cannabichromene , trans-delta-8-tetrahydrocannabinol and delta-9-tetrahydrocannabinol , were identified . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
24,
36
]
} | {
"id": "C0039663",
"name": "delta-9-tetrahydrocannabinol",
"pos": [
166,
194
]
} |
fructosamine concentration was not related to uraemia and did not depend on albumin or total protein concentrations , provided that serum albumin concentrations remained above 30 g/l . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
76,
83
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
132,
145
]
} |
a study of 318 patients with tubal infertility and a control group of 200 unselected infertile women yielded 14 ( 4.4 % ) and 1 ( 0.5 % ) , respectively , with precancerous lesions of the cervix uteri . | NA | {
"id": "C0021359",
"name": "infertility",
"pos": [
35,
46
]
} | {
"id": "C0021361",
"name": "infertile women",
"pos": [
85,
100
]
} |
the lupus anticoagulant was found in the plasma of 31 of 60 patients with systemic lupus erythematosus and other connective tissue disorders ( mixed connective tissue disease , systemic vasculitis , polyarteritis nodosa , primary sicca syndrome , discoid lupus , behcet 's syndrome , and systemic sclerosis ) . | NA | {
"id": "C0009782",
"name": "connective tissue disorders",
"pos": [
113,
140
]
} | {
"id": "C0026272",
"name": "mixed",
"pos": [
143,
148
]
} |
the lupus anticoagulant was found in the plasma of 31 of 60 patients with systemic lupus erythematosus and other connective tissue disorders ( mixed connective tissue disease , systemic vasculitis , polyarteritis nodosa , primary sicca syndrome , discoid lupus , behcet 's syndrome , and systemic sclerosis ) . | NA | {
"id": "C0009782",
"name": "connective tissue disorders",
"pos": [
113,
140
]
} | {
"id": "C0036421",
"name": "systemic sclerosis",
"pos": [
288,
306
]
} |
one hundred and nine patients with genital ulcers ( 75 men and 34 women ) seen at the special treatment clinic in nairobi , kenya , were randomly assigned to treatment with a seven day course of either sulphamethoxazole 1000 mg twice daily or trimethoprim ( 160 mg ) -sulphamethoxazole ( 800 mg ) ( tmp-smx ) twice daily . | NA | {
"id": "C0038689",
"name": "sulphamethoxazole",
"pos": [
202,
219
]
} | {
"id": "C0041044",
"name": "tmp-smx",
"pos": [
299,
306
]
} |
treatment with sulphamethoxazole failed in five of 21 ( 24 % ) culture positive patients who were available for evaluation after seven days , whereas all 19 of such patients who were treated with tmp-smx responded to treatment . | NA | {
"id": "C0038689",
"name": "sulphamethoxazole",
"pos": [
15,
32
]
} | {
"id": "C0041044",
"name": "tmp-smx",
"pos": [
196,
203
]
} |
the water-soluble inhibitory benzodiazepine , midazolam , was applied in low nanomolar concentrations to ca1 hippocampal neurons in vitro , recorded intracellularly . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
29,
43
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
46,
55
]
} |
studies performed on superfused synaptosomes from brain areas rich in dopaminergic nerve endings did not show any influence of the etomidate , 10 ( -7 ) m-10 ( -6 ) m , on [ 3h ] dopamine release . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
70,
82
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
179,
187
]
} |
we studied the activity of angiotensin i converting enzyme ( ace , kininase ii , e.c . 3.4.15.1 ) in discrete areas of the brainstem and limbic system , and in circumventricular organs , pineal gland and choroid plexus of homozygous brattleboro rats ( di ) which are characterized by vasopressin deficiency and diabetes insipidus , with or without vasopressin replacement . | NA | {
"id": "C0687720",
"name": "vasopressin deficiency",
"pos": [
284,
306
]
} | {
"id": "C0011848",
"name": "diabetes insipidus",
"pos": [
311,
329
]
} |
systemic administration of excitatory amino acids ( glu or nma ) rapidly enhances lh release ( rodents or primates ) and gaba blocks this action ( rodents ) . | NA | {
"id": "C0243046",
"name": "excitatory amino acids",
"pos": [
27,
49
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
52,
55
]
} |
l-dopa is believed to be decarboxylated by the residual striatal dopaminergic presynaptic terminals with formation of the putative neurotransmitter dopamine ( da ) and with increased availability of da at post-synaptic receptors . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
65,
77
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
199,
201
]
} |
storage of biogenic amines was studied in the notochord of the lamprey ( lampetra planeri ) after injection of cold or tritiated amines or their precursors . | NA | {
"id": "C0005496",
"name": "biogenic amines",
"pos": [
11,
26
]
} | {
"id": "C0002508",
"name": "amines",
"pos": [
129,
135
]
} |
the glycosaminoglycans thus prepared consisted only of chondroitin-4-sulfate , chondroitin-6-sulfate , and small amounts of highly hybridized dermatan sulfate , while the experiments failed to demonstrate even trace amounts of keratan sulfate , hyaluronic acid or heparan sulfate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
4,
22
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
264,
279
]
} |
forty 5-week-old rats were randomly divided into 1 control group given a normal diet and water low in fluoride ( 0.026 mm/1 ) and experimental group receiving the same basic diet and a fluoride supplement of 2.6 mmol/l in the drinking water . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
89,
94
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
226,
240
]
} |
calcergy and calciphylaxis , experimentally induced models of pathologic calcification , offer the opportunity to study the formation of mineral deposits in the absence of an endochondral sequence of bone formation . | NA | {
"id": "C0006666",
"name": "calciphylaxis",
"pos": [
13,
26
]
} | {
"id": "C0006663",
"name": "pathologic",
"pos": [
62,
72
]
} |
these findings suggest that arachidonic acid metabolites mediate ( slow reacting substances ) and modulate ( prostaglandins ) allergic contraction of human airway smooth muscle while any histamine released contributes little or nothing to the contraction in the larger airways . | NA | {
"id": "C0037343",
"name": "slow reacting substances",
"pos": [
67,
91
]
} | {
"id": "C0019588",
"name": "histamine",
"pos": [
187,
196
]
} |
the kinetic values km and vmax measured by a microacidimetric method showed that all three types of enzymes are cephalosporinases and did not hydrolyse oxacillin , cloxacillin , and methicillin . | NA | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
152,
161
]
} | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
164,
175
]
} |
regression analysis has shown that the ferguson and cobb methods of measuring spinal curvature give comparable results , at least before the scoliosis is treated . | NA | {
"id": "C0037932",
"name": "spinal curvature",
"pos": [
78,
94
]
} | {
"id": "C0036439",
"name": "scoliosis",
"pos": [
141,
150
]
} |
ketoprofen was significantly superior to placebo in relieving the pain ( p less than 0.001 ) , disability ( p less than 0.001 ) and headache ( p less than 0.01 ) associated with menstruation . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
66,
70
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
132,
140
]
} |
although relapse probably represented regrowth of clinically quiescent tumor , it is also possible that these were second malignancies , perhaps occurring in a predisposed host . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
71,
76
]
} | {
"id": "C0085183",
"name": "second malignancies",
"pos": [
115,
134
]
} |
a phase iii trial comparing prednimustine ( leo 1031 ) to chlorambucil plus prednisolone in advanced breast cancer . | NA | {
"id": "C0032949",
"name": "prednimustine",
"pos": [
28,
41
]
} | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
58,
70
]
} |
the objective of the current study is to compare the clinical effectiveness and toxicity of prednimustine with its components of chlorambucil plus prednisolone , and to compare the clinical effectiveness and toxicity of a continuous treatment with an intermittent one . | NA | {
"id": "C0032949",
"name": "prednimustine",
"pos": [
92,
105
]
} | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
129,
141
]
} |
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