text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the response rates were 21 % in both of the prednimustine-treated groups , whereas only 11 % of the patients treated with chlorambucil and prednisolone responded . | NA | {
"id": "C0032949",
"name": "prednimustine",
"pos": [
44,
57
]
} | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
122,
134
]
} |
no differences were observed between the two prednimustine-treated groups , whereas the group treated with chlorambucil plus prednisolone experienced a significantly higher degree of leukopenia and/or thrombopenia . | NA | {
"id": "C0032949",
"name": "prednimustine",
"pos": [
45,
58
]
} | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
107,
119
]
} |
the presence or absence of these tumor-associated glycoproteins appeared to be correlated with the histologic type of the tumors , especially in small cell anaplastic carcinoma and adenocarcinoma , and the degree of histologic differentiation of adenocarcinomas correlated positively with these tumor-associated antigens . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
33,
38
]
} | {
"id": "C0027652",
"name": "histologic type of",
"pos": [
99,
117
]
} |
it contained all of the commonly occurring amino acids and had an acidic to basic amino acid ratio of 1.4 . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
43,
54
]
} | {
"id": "C0815040",
"name": "acidic",
"pos": [
66,
72
]
} |
these findings establish that conjugates containing ifn linked to a monoclonal antibody reacting with osteogenic sarcoma-associated antigens have potential for targeted immunotherapy and in related investigations with antibody has been shown by gamma camera imaging of patients following infusion of 131i-labelled antibody to localize in primary osteogenic sarcomas . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
68,
87
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
314,
322
]
} |
hexestrol induced the same incidence and number of renal carcinoma foci as des or 17 beta-estradiol . | NA | {
"id": "C0019467",
"name": "hexestrol",
"pos": [
0,
9
]
} | {
"id": "C0012203",
"name": "des",
"pos": [
75,
78
]
} |
since accumulation of this high-molecular-weight rna has been associated with fluoropyrimidine toxicity and impaired ribosomal rna processing , it is believed that tam enriched the rna-mediated toxicity of fura and furd in this breast carcinoma cell line . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
117,
130
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
181,
184
]
} |
that factor might be identical to a recently identified rabbit monokine that stimulates fibroblasts or synovial cells to degrade collagen and proteoglycan and to activate plasminogen , because rabbit macrophage-conditioned media containing that monokine also stimulated collagen degradation by llc cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
88,
99
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
298,
303
]
} |
both types of clones did not bear antigens cross-reacting with the antiserum against mouse spleen cells but had surface antigens which were affected by the antibody against hl-60 cells and complement . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
67,
76
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
156,
164
]
} |
when normal or transformed human fibroblasts are incubated with actinomycin d , rna synthesis is irreversibly inhibited , and the treated cells eventually die . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
33,
44
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
138,
143
]
} |
the anionic property of the enzyme was found to be due to phosphate groups bound to the carbohydrate moiety of the arylsulfatase , based on the following results . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
4,
11
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
58,
67
]
} |
data obtained by the 13c-n.m.r.-spectral analysis of the smith-degradation product revealed that it was a linear-backbone polysaccharide analogous to a rhodotorula glutinis mannan , but composed of pairs of 2-acetamido-2-deoxymannopyranosyl residues alternately linked beta- ( 1 leads to 3 ) and beta- ( 1 leads to 4 ) . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
122,
136
]
} | {
"id": "C0024727",
"name": "mannan",
"pos": [
173,
179
]
} |
in contrast , in the other 28 hearts ( group 2 ) glucose utilisation ( 5.1 +/- 0.4 mumol . min-1 . g-1 dry wt ) and estimated glycolytic flux ( 4.1 +/- 0.01 mumol hexose . min-1 . g-1 dry wt ) were increased during ischaemia . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
49,
56
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
163,
169
]
} |
further , lower levels of amp and camp were observed and creatine phosphate : creatine ratios were better maintained . | NA | {
"id": "C0031634",
"name": "creatine",
"pos": [
57,
65
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
78,
86
]
} |
the results obtained from the functional and morphological examinations were well correlated , indicating the most severe changes in animals given gentamicin followed , in order , by amikacin , tobramycin , kanamycin , dibekacin , and ribostamycin . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
183,
191
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
207,
216
]
} |
the results obtained from the functional and morphological examinations were well correlated , indicating the most severe changes in animals given gentamicin followed , in order , by amikacin , tobramycin , kanamycin , dibekacin , and ribostamycin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
207,
216
]
} | {
"id": "C0012024",
"name": "dibekacin",
"pos": [
219,
228
]
} |
in untreated juvenile trout the gonadotropin content of the pituitary and the gonadotropin concentration in the plasma vary with the time of year . | NA | {
"id": "C0018066",
"name": "gonadotropin",
"pos": [
32,
44
]
} | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
78,
90
]
} |
a chronobiological study was carried out in headache syndromes due to empty sella or to pituitary g.h.- and prl-secreting adenomas . | NA | {
"id": "C0014008",
"name": "empty",
"pos": [
70,
75
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
88,
97
]
} |
a dyschronic hypothesis of primary headache must be based upon observations demonstrating that along with dysfunctions of the pain control systems there is also a vulnerability of the rhythmic physiological organization of cns . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
35,
43
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
126,
130
]
} |
the apparent analgesic effect of prolactin has been related to the stimulation of nigro-striatal dopaminergic transmission , as suggested by the increase in striatal dopamine turnover observed in hyperprolactinaemic rats . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
97,
109
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
166,
174
]
} |
reca protein promotes homologous pairing by a reaction in which the protein first binds stoichiometrically to single-stranded dna in a slow presynaptic step , and then conjoins single-stranded and duplex dna , thereby forming a ternary complex . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
110,
129
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
204,
207
]
} |
the killing of atf by ctl-like cells was not inhibited by felv/fesv immune sera or by sera from autochthonous immune cats . | NA | {
"id": "C0016030",
"name": "atf",
"pos": [
15,
18
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
31,
36
]
} |
colchicine , demecolcine and vinblastine all effectively inhibited the pinocytic capture of 125i-labelled poly ( vinylpyrrolidone ) by rat visceral yolk sacs cultured in vitro . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
0,
10
]
} | {
"id": "C0011259",
"name": "demecolcine",
"pos": [
13,
24
]
} |
inhibition of pinocytosis by demecolcine was reversible , whereas inhibition by colchicine or vinblastine was not . | NA | {
"id": "C0011259",
"name": "demecolcine",
"pos": [
29,
40
]
} | {
"id": "C0009262",
"name": "colchicine",
"pos": [
80,
90
]
} |
in terms of dose-response demecolcine was slightly more effective than colchicine , but both were considerably more active than trimethylcolchicinic acid . | NA | {
"id": "C0011259",
"name": "demecolcine",
"pos": [
26,
37
]
} | {
"id": "C0009262",
"name": "colchicine",
"pos": [
71,
81
]
} |
syrian hamsters were treated with either a low ( 10 mg/kg body weight ) or high ( 40 mg/kg body weight ) single dose of bis ( 2-oxopropyl ) nitrosamine ( bop ) and beginning 1 week later fed either low ( 0.2 mmol/kg diet ) or high ( 0.4-1.0 mmol/kg diet ) levels of one of four retinoids [ 13 cis retinoic acid ( 13-cis-ra ) , n-ethylretinamide ( era ) , n- ( 2-hydroxyethyl ) retinamide ( ohera ) or n- ( phenyl ) retinamide ( pra ) ] for periods of 40 or 50 weeks . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
278,
287
]
} | {
"id": "C0022265",
"name": "13 cis retinoic acid",
"pos": [
290,
310
]
} |
within normal fibroblasts only one cellular form of np ( np1 ) is detectable indicating that synthesis of np2 is associated only with the release of virus from these normal cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
14,
25
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
166,
178
]
} |
thus , assessment of influenza a gene expression may have detected a novel cellular protease which is incrementally elevated along with tumorigenic potential of this human fibroblast family . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
75,
83
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
172,
182
]
} |
treatment of bovine lymphocytes with phorbol esters activates an oxygen-dependent system for the formation of a class of arachidonic acid metabolites which appears distinct from prostaglandins , prostacyclins , thromboxanes and leukotrienes . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
178,
192
]
} | {
"id": "C0205911",
"name": "prostacyclins",
"pos": [
195,
208
]
} |
sarcoplasm and mitochondria of most hypoxic myocytes exhibited significant alterations of diffusible elements , including increases in sodium and chloride and decreases in potassium , phosphorus , and magnesium , without major change in calcium . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
101,
109
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
184,
194
]
} |
thus x-ray microanalysis of unfixed cryosections provides direct measurements of subcellular alterations in elemental composition of individual myocytes in injured myocardium and demonstrates that both calcium and phosphorus accumulate in mitochondria of severely injured myocytes in concentrations sufficient to exert deleterious effects on these organelles . | NA | {
"id": "C0013879",
"name": "elemental",
"pos": [
108,
117
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
214,
224
]
} |
parasystole , reentry , and tachycardia : a canine preparation of cardiac arrhythmias occurring across inexcitable segments of tissue . | NA | {
"id": "C0206068",
"name": "parasystole",
"pos": [
0,
11
]
} | {
"id": "C0003811",
"name": "cardiac",
"pos": [
66,
73
]
} |
the affinity of the usual and atypical homozygotes for fluoride with butyrylthiocholine gave an inverted response to the affinity of these variants for the anion with benzoylcholine . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
55,
63
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
156,
161
]
} |
the assay performs well in hypothyroidism and hyperthyroidism , and distinguishes individuals with thyroid disease from normal individuals . | NA | {
"id": "C0020676",
"name": "hypothyroidism",
"pos": [
27,
41
]
} | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
99,
114
]
} |
the assay performs well in hypothyroidism and hyperthyroidism , and distinguishes individuals with thyroid disease from normal individuals . | NA | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
46,
61
]
} | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
99,
114
]
} |
application of immunofixation electrophoresis in attempts to identify the band with use of monospecific antibodies against individual human serum proteins and against heavy- and light-chain immunoglobulins as well as polyvalent antisera did not produce a positive immunoprecipitation reaction with the protein band . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
104,
114
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
228,
236
]
} |
comparison of cholesterol concentrations in hdl subfractions in the one year treated subjects with those in a control group of untreated subjects suggests that the fall in hdl cholesterol is due to reductions in both the hdl2 and hdl3 fractions . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
14,
25
]
} | {
"id": "C0023822",
"name": "hdl cholesterol",
"pos": [
172,
187
]
} |
free norepinephrine ( ne ) in plasma was within the normal range in two patients and plasma free epinephrine ( e ) was only marginally elevated in one of them . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
5,
19
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
97,
108
]
} |
women who experienced only a single day of post-partum blues had significantly lower levels of noradrenaline and adrenaline on that day compared with preceding or subsequent days . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
95,
108
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
113,
123
]
} |
the liver is important in the transport , metabolism , storage and excretion of thyroid hormones as well as being an important site for hormone activity . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
42,
52
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
67,
76
]
} |
these studies demonstrate the feasibility of obtaining f ( ab ' ) 2 fragments with antibody activity from isolated cic and the presence of a disease specific antibody specificity in as cic . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
83,
91
]
} | {
"id": "C0003313",
"name": "cic",
"pos": [
185,
188
]
} |
effect on the human complement system of the major non-steroidal anti-inflammatory drugs : aspirin , indomethacin , phenylbutazone , oxyphenbutazone and sulindac . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
116,
130
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
133,
148
]
} |
treatment of fresh human serum with indomethacin ( idm ) , sulindac ( su ) , phenylbutazone ( ph ) and oxyphenbutazone ( oph ) inhibited both the classical and alternative complement ( c ) pathway activities in a dose-dependent fashion with a 50 % inhibition dose of 4.65 , 1.0 , 1.65 and 1.3 mg/ml respectively . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
77,
91
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
103,
118
]
} |
su , ph and oph were shown to form complexes with c5 , thereby inhibiting the interaction between c3b and c5 and the cleavage of the latter into phlogistic fragments . | NA | {
"id": "C0031463",
"name": "ph",
"pos": [
5,
7
]
} | {
"id": "C0030078",
"name": "oph",
"pos": [
12,
15
]
} |
comparisons of the hla antigen frequencies in normal controls and in different subsets of patients with malignant choroidal melanoma , partitioned on the basis of histological tumour cell types and inclusion of the splits of all the hla-a and -b locus antigens , revealed significant heterogenity only in hla-b ( p = 0.043 ) in the 'pure spindle ' cell type choroidal melanomas . | NA | {
"id": "C0019721",
"name": "hla antigen",
"pos": [
19,
30
]
} | {
"id": "C0019737",
"name": "hla-b",
"pos": [
305,
310
]
} |
these included eight patients with common variable immune deficiency , three patients with x-linked agammaglobulinaemia , two patients with the wiskott-aldrich syndrome , three patients with ataxia telangiectasia , three patients with immunodeficiency and normal serum immunoglobulin concentrations , one patient with immune deficiency and hyper-igm syndrome , two patients with job syndrome and one patient with a granulocyte adherence defect . | NA | {
"id": "C0009447",
"name": "common",
"pos": [
35,
41
]
} | {
"id": "C0021051",
"name": "immune deficiency",
"pos": [
318,
335
]
} |
significantly depressed lymphocyte migration in response to casein and c5a was observed in patients with common variable immune deficiency , patients with immune deficiency and normal immunoglobulin concentration , and patients with job syndrome . | NA | {
"id": "C0009447",
"name": "common variable immune",
"pos": [
105,
127
]
} | {
"id": "C0021051",
"name": "immune deficiency",
"pos": [
155,
172
]
} |
when il-2 production by pha stimulated cells was measured culture supernatants from the three t helper cell leukaemias all showed normal or high levels of activity , when compared to normal blood mononuclear cells , whereas the t suppressor cell leukaemia showed no activity . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
39,
44
]
} | {
"id": "C1321301",
"name": "blood mononuclear cells",
"pos": [
190,
213
]
} |
taking into account the specific hepatobiliary transport by polymeric iga of circulating antigens entering through the mucosal surfaces we examined the possible involvement of antibodies against food antigens in the circulating ic and the existence of a defect in their blood clearance in patients with iga nephropathy . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
176,
186
]
} | {
"id": "C0003313",
"name": "ic",
"pos": [
228,
230
]
} |
better understanding of the pathogenetic significance of antibodies to liver membrane antigens in cah and other liver diseases will depend upon biochemical analysis of the presumably multiple antigenic determinants on the hepatocyte membrane . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
86,
94
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
192,
214
]
} |
since the growth of fibroblasts requires that these cells be attached to an extracellular support , the current study was designed to determine if the interaction between the fibroblast attachment factor fibronectin and the c1q component of complement could support fibroblast attachment and growth and thus could form a basis for the attachment of fibroblasts in abnormal tissue locations in those inflammatory states where c1q is bound . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
52,
57
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
349,
360
]
} |
since the immunoblot pattern obtained with mctd sera mostly was clearly distinguishable from the patterns obtained with sera from patients with related connective tissue diseases our results suggest that the immunoblotting technique might be useful as a diagnostic tool and support the concept of mctd as a distinct entity . | NA | {
"id": "C0026272",
"name": "mctd",
"pos": [
43,
47
]
} | {
"id": "C0009782",
"name": "the",
"pos": [
282,
285
]
} |
dysmorphic ( i.e . morphologically variable ) erythrocytes , suggestive of glomerular bleeding , were present in 86 of 87 patients with significant hematuria who were later shown to have glomerulonephritis . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
86,
94
]
} | {
"id": "C0018965",
"name": "hematuria",
"pos": [
148,
157
]
} |
the potential impact of e prostaglandins on articular cartilage should be considered in clinical situations associated with elevated intra-articular prostaglandin levels ( trauma , meniscal injury , arthritis , etc . ) . | NA | {
"id": "C0033559",
"name": "e prostaglandins",
"pos": [
24,
40
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
149,
162
]
} |
subjects who had expected the pregnancy to occur tended to report less stress during the third trimester than did teens who had not anticipated conception . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
30,
39
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
89,
104
]
} |
with continuous ambulatory ecg recordings , we determined the incidence of arrhythmias in seven male hypertensive patients ( without active heart disease ) after abrupt clonidine withdrawal . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
75,
86
]
} | {
"id": "C0018799",
"name": "heart disease",
"pos": [
140,
153
]
} |
changes in mean arterial pressure ( map ) , heart rate ( hr ) , and plasma concentrations of norepinephrine ( ne ) and epinephrine were measured in eight hypertensive patients in a supine position after stepwise infusion of incremental sodium nitroprusside doses and intravenous injection of cumulative labetalol doses . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
93,
107
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
119,
130
]
} |
mean arterial pressure ( map ) , heart rate ( hr ) , and plasma norepinephrine ( ne ) and epinephrine concentrations were determined before and after dosing . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
64,
78
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
90,
101
]
} |
blood glucose and serum insulin rose further during dialysis , particularly with hypertonic ( 215 mmol of glucose/l ) dialysis fluid and levels remained high for 6 h after the onset . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
0,
13
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
106,
113
]
} |
fifteen minutes after the blisters had been formed and the suction had been stopped , 125i-albumin was injected intravenously and the disappearance of the tracer protein from plasma was compared to its appearance in blister fluid as a function of time for up to 4 h after the injection . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
91,
98
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
162,
169
]
} |
the enolase ( 2-phospho-d-glycerate hydrolyase e.c . 4.2.1.11 ) from carp muscle was obtained , the specific activity -- 88 u/mg of protein . | NA | {
"id": "C0031691",
"name": "enolase",
"pos": [
4,
11
]
} | {
"id": "C0020239",
"name": "hydrolyase",
"pos": [
36,
46
]
} |
isolation of the furocoumarins ( psoralens ) bergapten , isobergapten , sphondin , isopimpinellin and pimpinellin from the umbilliferous plant heracleum laciniatum was carried out by column chromatography , and the structure and absorption spectra for the 5 furocoumarins isolated are described . | NA | {
"id": "C0033858",
"name": "psoralens",
"pos": [
33,
42
]
} | {
"id": "C0016859",
"name": "furocoumarins",
"pos": [
258,
271
]
} |
the effect of vaginal gossypol-containing gel on spermatozoa was determined by postcoital tests performed in subjects without and after using gossypol gel . | NA | {
"id": "C0042257",
"name": "vaginal",
"pos": [
14,
21
]
} | {
"id": "C0017243",
"name": "gel",
"pos": [
151,
154
]
} |
an antiserum ( pc-81-1 ) was obtained from a man who developed antibodies against hcg during treatment for hypogonadism . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
3,
12
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
63,
73
]
} |
this study demonstrates the feasibility of cardiac pacing in out-of-hospital cardiac arrest but confirms the poor prognosis of asystolic cardiac arrest even with the application of pacing . | NA | {
"id": "C2936490",
"name": "out-of-hospital cardiac arrest",
"pos": [
61,
91
]
} | {
"id": "C0018790",
"name": "cardiac arrest",
"pos": [
137,
151
]
} |
in all studies , variations in beta-lipoprotein or ldl-c levels could not be explained by changes in blood volume , serum glucose or insulin and did not correlate with alterations in blood pressure , plasma potassium , renin , aldosterone , adrenaline or noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
241,
251
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
255,
268
]
} |
comparison of the methods of determination of conjugated catecholamines shows that , despite their variable absolute values , the relative proportions of the free and conjugated dopamine , norepinephrine and epinephrine are close ( mean of 97.3 % of dopamine , 73 % of norepinephrine and 84 % of epinephrine being conjugated ) and these proportions remain similar whether acid or sulphatase hydrolysis is used . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
189,
203
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
296,
307
]
} |
previous studies have shown that the tumorigenic potential of hybrids cells formed between a variety of human tumor cell lines and normal human fibroblasts is completely suppressed . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
33,
36
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
144,
155
]
} |
the effects of adamantane , amantadine , and glucosamine on the interferon induction in chickens as compared to mice were studied . | NA | {
"id": "C0001392",
"name": "adamantane",
"pos": [
15,
25
]
} | {
"id": "C0002403",
"name": "amantadine",
"pos": [
28,
38
]
} |
data obtained show that adamantane and its derivative amantadine are able to inhibit the 'in vivo ' interferon synthesis only when viral inductors are used ; | NA | {
"id": "C0001392",
"name": "adamantane",
"pos": [
24,
34
]
} | {
"id": "C0002403",
"name": "amantadine",
"pos": [
54,
64
]
} |
comparison of maternal/fetal blood sample pairs from 60 to 300 min after initiation of the ethanol infusion revealed a significant correlation of blood ethanol concentration ( r = 0.968 , p less than 0.001 ) . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
91,
98
]
} | {
"id": "C0684262",
"name": "blood ethanol",
"pos": [
146,
159
]
} |
the delta-q criterion was equally as efficient as st in mvd patients without mi and with diaphragmatic mi . | NA | {
"id": "C0027051",
"name": "mi",
"pos": [
77,
79
]
} | {
"id": "C0340305",
"name": "diaphragmatic mi",
"pos": [
89,
105
]
} |
a parasitic disease model ( sarcocystosis ) was used to study the effects of infection and associated plane of nutrition on gh and somatomedin-c ( sm-c ) patterns in plasma , and sm-c binding protein patterns in plasma from 4-month-old male holstein calves . | NA | {
"id": "C0030499",
"name": "parasitic disease",
"pos": [
2,
19
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
77,
86
]
} |
the effect of two analogues of [ met ] -enkephalin , [ d-ala2 , n-phe4 , met ( 0 ) -ol5 ] -enkephalin and its guanyl derivative , on plasma concentrations of atrial natriuretic peptide ( anp ) and serum aldosterone in six normal subjects was investigated . | NA | {
"id": "C0014295",
"name": "met",
"pos": [
33,
36
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
91,
101
]
} |
packed red cell volume increased , as did pituitary venous concentrations of adrenaline ( mean +/- s.e.m . concentration before isolation , 621.5 +/- 112.3 pmol/l ; peak during isolation , 2665.4 +/- 869.8 pmol/l ; p less than 0.05 ) and noradrenaline ( before , 871.8 +/- 111.8 pmol/l ; peak , 2726.1 +/- 547.4 pmol/l ; p less than 0.02 ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
77,
87
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
238,
251
]
} |
the aim of the present study involving intact and ovariectomized prepubertal ewe lambs was to compare the effects in vivo of an opioid peptide agonist [ d-ala2 , n-phe4 , met ( 0 ) ol5 ] -enkephalin ( fk 33-824 ) and antagonist , naloxone , on concentrations of lh and prolactin in plasma , and levels of neurotransmitter metabolites in cerebrospinal fluid ( csf ) , with their effects in vitro on the release of gonadotrophin-releasing hormone ( gnrh ) and neurotransmitters from isolated median eminences . | NA | {
"id": "C0205753",
"name": "opioid peptide",
"pos": [
128,
142
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
188,
198
]
} |
like these homologous rat proteins , the human mannose-binding protein cooh-terminal sequences are homologous to the carbohydrate recognition portion of several other lectin-like proteins including mammalian hepatic receptors , an insect-soluble hemolymph , and a sea urchin lectin found in coelomic fluid . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
26,
34
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
275,
281
]
} |
the apoproteins of dog and human surfactant and the human lymphocyte ige ec receptor have not been shown to have lectin-like properties , yet by homology are members of this family of lectin-like proteins . | NA | {
"id": "C0003601",
"name": "apoproteins",
"pos": [
4,
15
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
196,
204
]
} |
the apoproteins of dog and human surfactant and the human lymphocyte ige ec receptor have not been shown to have lectin-like properties , yet by homology are members of this family of lectin-like proteins . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
113,
119
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
196,
204
]
} |
these results suggest that there is an important difference between immunodominant epitopes and minor epitopes and that ir gene-controlled low responsiveness to a natural whole protein may be due primarily to the failure to respond to a single immunodominant site , even though a number of other epitopes can be recognized . | NA | {
"id": "C0079600",
"name": "immunodominant epitopes",
"pos": [
68,
91
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
296,
304
]
} |
the opsonic and three nonopsonic antibodies were selected for isotype and complement fixation studies based on previous knowledge of their epitope site on the m6 molecule . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
33,
43
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
62,
69
]
} |
the order of agonist potency was consistent with that of an a2 adenosine receptor ( neca greater than pia greater than or equal to adenosine ) . | NA | {
"id": "C0050789",
"name": "neca",
"pos": [
84,
88
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
131,
140
]
} |
the order of agonist potency was consistent with that of an a2 adenosine receptor ( neca greater than pia greater than or equal to adenosine ) . | NA | {
"id": "C0031484",
"name": "pia",
"pos": [
102,
105
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
131,
140
]
} |
the set of natural antibodies identified in this study may be unique or may represent a class of antibodies present in the repertoire that , by virtue of the obscurity of their origin or function , have not been previously or extensively recognized . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
19,
29
]
} | {
"id": "C0021017",
"name": "class",
"pos": [
88,
93
]
} |
the principal surface protein antigen of chlamydia trachomatis is the major outer membrane protein ( momp ) . | NA | {
"id": "C0025252",
"name": "surface protein",
"pos": [
14,
29
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
91,
98
]
} |
we have found that a relatively high frequency of cll patients have leukemic b cells with surface immunoglobulin ( sig ) recognized by 17.109 , a murine mab specific for a kappa light chain associated crossreactive idiotype ( cri ) associated with rheumatoid factor and other igm autoantibodies . | NA | {
"id": "C0035448",
"name": "rheumatoid factor",
"pos": [
248,
265
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
280,
294
]
} |
scatchard plot analysis indicated that 125i-il-1 alpha binding increased from approximately 100 il-1-r per cell to 2 x 10 ( 3 ) receptors per cell without a major change in affinity ( kd = 2.6 x 10 ( -10 ) m ) . | NA | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
44,
54
]
} | {
"id": "C0021755",
"name": "il-1",
"pos": [
96,
100
]
} |
this protein , which is also present in mock-infected cells , has been identified as a host cell thioredoxin by similarities in its physical characteristics with other thioredoxins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
5,
12
]
} | {
"id": "C0039938",
"name": "thioredoxins",
"pos": [
168,
180
]
} |
these observations suggest that glycosylation of gp88 selectively influences the integrity of antigenic sites a-1 and a-2 which are composed of conformation-dependent epitopes . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
94,
103
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
167,
175
]
} |
measles virus fusion protein presented in an immune-stimulating complex ( iscom ) induces haemolysis-inhibiting and fusion-inhibiting antibodies , virus-specific t cells and protection in mice . | NA | {
"id": "C0003313",
"name": "immune",
"pos": [
45,
51
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
134,
144
]
} |
a whole mv iscom preparation , which also contained the haemagglutinin protein , induced not only also haemolysis-inhibiting antibodies , but , in contrast to the f iscom preparation , also haemagglutination-inhibiting and virus-neutralizing antibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
125,
135
]
} | {
"id": "C0003313",
"name": "iscom",
"pos": [
165,
170
]
} |
proteins ns3 and ns3a were present in very small amounts in the soluble fraction of the cytoplasm of infected cells , and were synthesized in variable amounts in vitro , whereas the other nine viral proteins were synthesized in constant molar ratios . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
0,
8
]
} | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
193,
207
]
} |
passively administered neutralizing antibodies directed against the 40k structural polypeptide of cu-1 confer protective immunity to susceptible chickens , whereas antibodies directed against the 32k structural protein do not have any protective effect . | NA | {
"id": "C0475463",
"name": "neutralizing",
"pos": [
23,
35
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
164,
174
]
} |
southern blot analysis of dna extracted from infected organs revealed replicative forms of viral dna in spleen and bone marrow samples only . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
26,
29
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
91,
100
]
} |
prion protein ( prp ) forms the fibrils or prion rods isolated from scrapie-infected brain and has been proposed as the major component of the infectious agent of this slowly progressive spongiform encephalopathy . | NA | {
"id": "C0036457",
"name": "scrapie",
"pos": [
68,
75
]
} | {
"id": "C0162534",
"name": "spongiform encephalopathy",
"pos": [
187,
212
]
} |
these results provide evidence that prp is a protein common to numerous , but not all , cell types besides those of the brain . | NA | {
"id": "C0033164",
"name": "prp",
"pos": [
36,
39
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
45,
52
]
} |
after initial problems related to denaturation of antigenic epitopes , we developed a western immunoblotting method for the characterization of antibodies reacting with bk virus ( bkv ) structural polypeptides . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
50,
59
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
60,
68
]
} |
it is suggested that amoxapine , an antidepressant structurally related to the neuroleptic loxapine , be added to the list of medications that can cause this potentially lethal syndrome . | NA | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
21,
30
]
} | {
"id": "C0024056",
"name": "loxapine",
"pos": [
91,
99
]
} |
bladder function in four patients with normal pressure hydrocephalus , one with dementia of alzheimer type and five patients with multi-infarct dementia was studied by history and urodynamic tests ( cystometry and bor 's ice water test ) . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
221,
224
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
225,
230
]
} |
ninety-four percent of the nonpsychiatric men with epilepsy received anticonvulsants , and none had experienced more than one seizure during the preceding year . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
51,
59
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
126,
133
]
} |
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