text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the oxidation of catechol by horseradish peroxidase and peroxidases present in human leukocytes was therefore examined . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
29,
51
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
56,
67
]
} |
comparison of the trichothecenes deoxynivalenol and t-2 toxin for their effects on brain biogenic monoamines in the rat . | NA | {
"id": "C0040952",
"name": "trichothecenes",
"pos": [
18,
32
]
} | {
"id": "C0039185",
"name": "t-2 toxin",
"pos": [
52,
61
]
} |
these results indicate that don and t-2 toxin influence brain biogenic monamine metabolism , and suggest that the central nervous system ( cns ) actions of these trichothecenes are similar . | NA | {
"id": "C0039185",
"name": "t-2 toxin",
"pos": [
36,
45
]
} | {
"id": "C0040952",
"name": "trichothecenes",
"pos": [
162,
176
]
} |
we used a rabbit model of ischemic infarction to examine the relation between controlled central nervous system ischemia and cerebrospinal fluid prostaglandin levels . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
35,
45
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
112,
120
]
} |
the loss of red cell alloantibodies over time was analyzed in 160 patients with 209 antibodies retested 1 to 60 months after initial identification . | NA | {
"id": "C0022144",
"name": "alloantibodies",
"pos": [
21,
35
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
84,
94
]
} |
twenty-five patients with advanced breast cancer were treated with 4-demethoxydaunorubicin ( 4-dmdr ) , a new antitumor analogue of daunorubicin , at the dose of 15-20 mg/m2/day x 3 days by oral route every 3-4 weeks . | NA | {
"id": "C0020789",
"name": "4-dmdr",
"pos": [
93,
99
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
132,
144
]
} |
compared with the group of clinically healthy cats , the specific antibodies occurred significantly more frequently in the cats suffering from diseases of the digestive tract ( p less than 0.01 ) , particularly in those with acute gastroenteritis , and in those having liver disorders ( p less than 0.01 ; p less than 0.05 ) . | NA | {
"id": "C0012242",
"name": "diseases of",
"pos": [
143,
154
]
} | {
"id": "C0023895",
"name": "liver disorders",
"pos": [
269,
284
]
} |
the results show that the routine passage of cells in culture leads to the emergence of the anchorage independent and tumorigenic phenotypes in keratinocytes of malignant origin and , further , suggest that anchorage independence and tumorigenicity may exist as distinct phenotypes , with anchorage independence preceding tumorigenicity . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0022567",
"name": "malignant",
"pos": [
161,
170
]
} |
the major dna-binding protein or infected cell protein 8 ( icp8 ) encoded by herpes simplex virus exhibits multiple interactions with the cell nucleus in that it interacts with the host cell nuclear matrix and viral dna molecules as sequential stages in its maturational process ( m. p. quinlan , l. b. chen , and d. m. knipe ( 1984 ) , cell 36 , 857-868 ) . | NA | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
10,
29
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
47,
54
]
} |
loss of antigenic reactivity of certain mutant g proteins to a mab other than the one used to select the mutant virus suggested close antigenic proximity , particularly for epitopes vi and vii . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
8,
17
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
173,
181
]
} |
the additional two changes occurred at positions 63 [ gln ( emc-b ) to glu ( emc-d ) ] and 181 [ thr ( emc-b ) to ser ( emc-d ) ] . | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
54,
57
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
71,
74
]
} |
an intratypic recombinant ( r-m1c1 ) , produced by cotransfection of hfem dna with a cloned mlul-mlul dna fragment ( coordinates 0.7615-0.796 ) from hsv-1 strain f , that was shown [ becker et al . ( 1986 ) . virology 149 , 255-259 ] to have regained partial ip virulence for mice , now transcribed alpha genes , synthesized viral dna , and induced cpe in m phi . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
74,
77
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
325,
334
]
} |
by 6 days postinfection ( p.i . ) , dna from bone marrow cells and peripheral blood leukocytes ( pbl ) contained between 0.50 and 0.70 copies of viral dna per haploid genome . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
36,
39
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
145,
154
]
} |
one of them buds from the plasma membrane and is responsible for systemic infection in insects and for the spread of infection in cell culture . | NA | {
"id": "C0243026",
"name": "systemic infection",
"pos": [
65,
83
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
117,
126
]
} |
the most frequently used rescue procedures are somewhat tedious , requiring the purification and fractionation of linear viral dna or dna fragments , and often involve the screening of numerous plaque isolates . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
121,
130
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
134,
137
]
} |
the transiently expressed m1 gene product comigrated on sds-polyacrylamide gels with the endogenous wsn virus m1 protein and was recognized in western blot analysis by three epitope-specific monoclonal antibodies directed to the m1 protein . | NA | {
"id": "C0042736",
"name": "virus",
"pos": [
104,
109
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
232,
239
]
} |
precipitation of 125i-labeled vpg with anti-tobacco etch virus 49k nuclear inclusion protein antiserum ( which reacts with the nia nuclear inclusion protein of tvmv ) indicated that the tvmv vpg is immunologically related to nia . | NA | {
"id": "C0042736",
"name": "virus",
"pos": [
57,
62
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
149,
156
]
} |
preferential indications for a diagnostic approach using radiolabelled granulocytes are inflammatory abdominal processes which can not easily be documented by means of other non-invasive techniques , such as inflammatory bowel disease ( crohn 's diseases and ulcerative colitis ) , arthritic processes and abscesses of the liver and spleen , as well as subphrenic and retroperitoneal abscesses . | NA | {
"id": "C0021390",
"name": "inflammatory bowel disease",
"pos": [
208,
234
]
} | {
"id": "C0010346",
"name": "crohn 's diseases",
"pos": [
237,
254
]
} |
the syntheses of the secondary hydroxylamines of nor1chlorpromazine and nor1promazine via their corresponding primary hydroxylamines and oximes are described . | NA | {
"id": "C0020363",
"name": "hydroxylamines",
"pos": [
31,
45
]
} | {
"id": "C0030020",
"name": "oximes",
"pos": [
137,
143
]
} |
examinations on 23 patients with hyperlipoproteinaemia and mixed hlp ( n = 15 ) and primary hypercholesterolaemia ( n = 8 ) after a 2 times 2 hours/day mutual stimulation of the femoral musculature in a frequency of 2 s-1 lasting four weeks yielded a significant decrease of the triglyceride and cholesterol concentrations as well as an increase of the hdl-cholesterol in mixed hlp-forms . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
97,
108
]
} | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
353,
368
]
} |
to determine the in vitro and in vivo activity of human antibody induced by different haemophilus influenzae type b ( hib ) vaccines , pooled human antisera obtained from adults immunized with either polyribosyl ribitol phosphate ( prp ) or prp-conjugated with diphtheria toxoid ( prp-d ) vaccines were evaluated for opsonic and protective activity against hib . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
56,
64
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
148,
156
]
} |
in vivo studies using the infant rat model or hib disease revealed that the decay of prp antibody was similar with prp or prp-d induced antisera in unchallenged rats . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
89,
97
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
136,
144
]
} |
this finding was shown by the significantly lower incidence of bacteraemia and the 5-fold lower dose of antibody required for 50 % protection against bacteraemia in rats receiving the prp-d induced antisera . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
104,
112
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
198,
206
]
} |
the cause of malabsorption was assumed to be rapid intestinal transit in four patients and bacterial overgrowth in four others , leaving three in whom pancreatic understimulation is suggested as the reason for steatorrhoea . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
13,
26
]
} | {
"id": "C0038238",
"name": "steatorrhoea",
"pos": [
210,
222
]
} |
expression of the leukemia-associated cell surface antigen p24 ( cd9 ) on human hematopoietic cell lines and b-cell chronic lymphocytic leukemia ( b-cll ) cells was analyzed before and after treatment with the phorbol ester 12-o-tetradecanoyl-phorbol 13-acetate ( tpa ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
210,
223
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol 13-acetate",
"pos": [
224,
261
]
} |
sixty-two patients with motor neuron disease ( mnd ) , encompassing amyotrophic lateral sclerosis ( als ) , progressive bulbar palsy ( pbp ) and progressive muscular atrophy ( pma ) , were selected from within a defined area ( cantabria ) in northern spain , from 1974 to 1985 . | NA | {
"id": "C0085084",
"name": "motor neuron disease",
"pos": [
24,
44
]
} | {
"id": "C0002736",
"name": "amyotrophic",
"pos": [
68,
79
]
} |
sixty-two patients with motor neuron disease ( mnd ) , encompassing amyotrophic lateral sclerosis ( als ) , progressive bulbar palsy ( pbp ) and progressive muscular atrophy ( pma ) , were selected from within a defined area ( cantabria ) in northern spain , from 1974 to 1985 . | NA | {
"id": "C0085084",
"name": "motor neuron disease",
"pos": [
24,
44
]
} | {
"id": "C0030442",
"name": "progressive bulbar palsy",
"pos": [
108,
132
]
} |
delayed hypersensitivity to rubber chemicals is well known but there are an increasing number of case reports on an immediate type of hypersensitivity inducing contact urticaria and anaphylaxis in adults . | NA | {
"id": "C0577628",
"name": "hypersensitivity to rubber",
"pos": [
8,
34
]
} | {
"id": "C0020517",
"name": "hypersensitivity",
"pos": [
134,
150
]
} |
the superior clinical efficacy of mr imaging relative to ct for the detection of hemorrhage was obvious except in the acute stage , when hematomas had an intensity similar to that of the adjacent brainstem , and the patients usually were in serious condition . | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
81,
91
]
} | {
"id": "C0018944",
"name": "hematomas",
"pos": [
137,
146
]
} |
thus , a set of 3 criteria from the selvester qrs scoring system is capable of identifying single non-acute anterior or inferior mi in 80 % of patients , and falsely indicating presence of mi in only 5 % of normal subjects . | NA | {
"id": "C0340305",
"name": "inferior mi",
"pos": [
120,
131
]
} | {
"id": "C0027051",
"name": "mi",
"pos": [
189,
191
]
} |
bma 120 ( formerly designated bw 200 ) is an endothelial cell specific monoclonal antibody detecting an epitope of a formalin resistant antigen . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
104,
111
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
136,
143
]
} |
however , within a given tissue or cell type , differences in the distributions of the antigens recognized by these two antibodies can be observed , raising the possibility of differential expression , modification , or masking of the keratin epitopes revealed by ucd/ab 6.11 and ucd/pr 10.11 . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
87,
95
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
243,
251
]
} |
they were most frequently observed in those who had died natural deaths ( particularly due to cardiovascular disease ) , followed by those who had died from asphyxia , head injury , and central nervous system disorders . | NA | {
"id": "C0011065",
"name": "died",
"pos": [
52,
56
]
} | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
157,
165
]
} |
petechiae can be important corroborative evidence of asphyxia , but are also seen in persons who have died of other means . | NA | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
53,
61
]
} | {
"id": "C0011065",
"name": "died",
"pos": [
102,
106
]
} |
in patients who develop o2-induced marrow red cell hypoplasia , cessation of o2 therapy may reverse the anemia and obviate the need for transfusion . | NA | {
"id": "C0034902",
"name": "red cell hypoplasia",
"pos": [
42,
61
]
} | {
"id": "C0002871",
"name": "anemia",
"pos": [
104,
110
]
} |
contrary to the reported experience in systemic lupus erythematosus and related autoimmune disorders , chlorpromazine-induced lupus anticoagulant and anticardiolipin antibodies levels appear not to be associated with an increased incidence of thrombosis . | NA | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
39,
67
]
} | {
"id": "C0004364",
"name": "autoimmune disorders",
"pos": [
80,
100
]
} |
platelet-derived growth factor ( pdgf ) has been suggested to play some role in the pathogenesis of myelofibrosis frequently encountered in patients with myeloproliferative disorders ( mpd ) . | NA | {
"id": "C0001815",
"name": "myelofibrosis",
"pos": [
100,
113
]
} | {
"id": "C0027022",
"name": "myeloproliferative disorders",
"pos": [
154,
182
]
} |
these results may support the idea that an abnormal release of pdgf occurs from platelets or megakaryocytes in the bone marrow environment , resulting in the stimulation of fibroblast proliferation , and hence , the occurrence of myelofibrosis in patients with mpd . | NA | {
"id": "C0001815",
"name": "myelofibrosis",
"pos": [
230,
243
]
} | {
"id": "C0027022",
"name": "mpd",
"pos": [
261,
264
]
} |
fifteen human volunteers were exposed to 1,1,1-trichloroethane ( methyl chloroform ) vapor at 72-495 mg/m3 for a period of 2 to 4 hours at rest ( ten cases ) and during light physical exercise ( five cases ) . | NA | {
"id": "C0040904",
"name": "trichloroethane",
"pos": [
47,
62
]
} | {
"id": "C0043697",
"name": "methyl",
"pos": [
65,
71
]
} |
impact of first-trimester chromosome , dna , and metabolic studies on pregnancies at high genetic risk : experience with 1,000 cases . | NA | {
"id": "C0032979",
"name": "first-trimester",
"pos": [
10,
25
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
70,
81
]
} |
the 101 metabolic studies involving 28 disorders were correct in 99 pregnancies in the first trimester . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
68,
79
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
87,
102
]
} |
a human cardiac myosin heavy-chain ( mhc ) gene , cloned in a charon 4a phage , was isolated using two rat cardiac pcmhc dna clones ( pcmhc26 : alpha-mhc type ; | NA | {
"id": "C0027100",
"name": "myosin heavy-chain",
"pos": [
16,
34
]
} | {
"id": "C0027096",
"name": "mhc",
"pos": [
150,
153
]
} |
the 133 evaluable patients generally were under 25 years of age , were nonwhite , and had hospital-acquired endometritis or pelvic inflammatory disease caused by both aerobic and anaerobic bacteria . | NA | {
"id": "C0014179",
"name": "endometritis",
"pos": [
108,
120
]
} | {
"id": "C0242172",
"name": "pelvic inflammatory disease",
"pos": [
124,
151
]
} |
this work suggests that an injury of the endothelial cells , directly or indirectly related to the presence of hiv , may be incriminated in the pathogenesis of sinusoidal lesions during hiv infection . | NA | {
"id": "C0021051",
"name": "hiv",
"pos": [
111,
114
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
186,
199
]
} |
the model assumes equilibrium of the creatine kinase reaction , which is modeled as a chemical capacitor , with capacitance proportional to the total creatine level , and pcr level proportional to the cytosolic free energy of atp hydrolysis . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
37,
45
]
} | {
"id": "C0031634",
"name": "pcr",
"pos": [
171,
174
]
} |
in conclusion , 1 ) gluconeogenesis from alanine is accelerated during exercise , due to an increase in the hepatic fractional extraction of the amino acid and through intrahepatic mechanisms that more efficiently channel it into glucose . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
41,
48
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
145,
155
]
} |
the effects of microiontophoresis of norepinephrine and epinephrine were examined on the spontaneous neuronal activity of single neurons in the nucleus tractus solitarius ( nts ) in urethan-anesthetized rats . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
37,
51
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
56,
67
]
} |
norepinephrine produced inhibitions in firing , which were blocked primarily by idazoxan , whereas epinephrine-induced neuronal inhibitions were blocked by either prazosin or idazoxan . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
99,
110
]
} |
to distinguish pattern differences in experimentally induced fevers , we investigated febrile responses induced by intravenous ( iv ) , intracerebroventricular ( icv ) , and intra-preoptic/anterior hypothalamic ( poa ) administration of bacterial endotoxin ( lipopolysaccharide , lps ) , endogenous pyrogen ( ep ) , human recombinant interleukin-1 alpha ( il-1 ) , and prostaglandins e2 and f2 alpha ( pge2 and pgf2 alpha ) . | NA | {
"id": "C0014264",
"name": "bacterial endotoxin",
"pos": [
237,
256
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
280,
283
]
} |
plasma epinephrine ( e ) and norepinephrine ( ne ) concentrations were measured ( radioenzymatic assay ) in blood samples simultaneously withdrawn from the aorta ( ao ) and coronary sinus ( cs ) on 10 anesthetized dogs immediately before and during a 1-min period of electrical stimulation of the left stellate ganglion ( 4 v , 4 ms , 10 hz ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
7,
18
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
29,
43
]
} |
plasma epinephrine ( e ) and norepinephrine ( ne ) removal from circulation and release into circulation were estimated from plasma ca arteriovenous differences across the regional vascular beds studied ( pulmonary , myocardial , hepatosplanchnic , renal , and skeletal muscle vascular beds ) and from regional blood flows . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
7,
18
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
29,
43
]
} |
a review of fine needle aspiration biopsies of lymph nodes was performed to determine accuracy and reproducibility among observers for the diagnosis of malignant lymphomas and lymphoproliferative diseases and to identify problem areas in the diagnosis of lymphomas and lymphoproliferative diseases by this biopsy method . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
162,
171
]
} | {
"id": "C0024314",
"name": "lymphoproliferative diseases",
"pos": [
269,
297
]
} |
a monoclonal antibody specific for a repeated epitope of the circumsporozoite protein of plasmodium malariae sporozoites has been used to develop a two-site , single antibody-based enzyme-linked immunosorbent assay that can detect p. malariae sporozoites in mosquitoes . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
2,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
166,
174
]
} |
on the basis of anterograde labeling with horseradish peroxidase-wheat germ agglutinine conjugate ( wga-hrp ) it was shown in this study that , in addition to muscle spindle compartmentalisation , there was also an exclusive occurrence of tendon organs in the red part of the muscle ; | NA | {
"id": "C0019941",
"name": "horseradish",
"pos": [
42,
53
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
100,
107
]
} |
differences between milrinone and amrinone were also studied during enflurane anesthesia in six other dogs given milrinone or amrinone at 3- to 4-week intervals using both a low dose that did not decrease mean arterial pressure significantly and a dose that decreased mean arterial pressure 20-25 % below baseline values . | NA | {
"id": "C0128513",
"name": "milrinone",
"pos": [
20,
29
]
} | {
"id": "C0002697",
"name": "amrinone",
"pos": [
126,
134
]
} |
the results of our studies show that during enflurane anesthesia 1 ) there is a correlation between milrinone plasma levels and improvement of cardiac performance and , 2 ) milrinone , at low and high doses studied without or with a significant decrease in mean arterial pressure , respectively , is similar to amrinone in its activity to improve cardiac performance by similar positive inotropic , chronotropic , and vasodilating effects . | NA | {
"id": "C0128513",
"name": "milrinone",
"pos": [
100,
109
]
} | {
"id": "C0002697",
"name": "amrinone",
"pos": [
311,
319
]
} |
an albuterol ( salbutamol ) sulphate solution was successfully administered endotracheally to a 67-year-old woman suffering severe bronchospasm and impending ventilatory arrest secondary to asthma . | NA | {
"id": "C0001927",
"name": "albuterol",
"pos": [
3,
12
]
} | {
"id": "C0543495",
"name": "salbutamol",
"pos": [
15,
25
]
} |
we studied the effects of neurokinin a ( nka ) and neurokinin b ( nkb ) , the mammalian-derived tachykinins , on the electrical and ion transport properties of canine tracheal epithelium . | NA | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
26,
38
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
96,
107
]
} |
we studied the effects of neurokinin a ( nka ) and neurokinin b ( nkb ) , the mammalian-derived tachykinins , on the electrical and ion transport properties of canine tracheal epithelium . | NA | {
"id": "C0027847",
"name": "neurokinin b",
"pos": [
51,
63
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
96,
107
]
} |
both tachykinins dose-dependently increased short-circuit current ( isc ) when added to the mucosal ( nka : delta isc ( max ) = 24.2 +/- 2.4 microa/cm2 , kd = 9 nm ; | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
5,
16
]
} | {
"id": "C0038581",
"name": "nka",
"pos": [
102,
105
]
} |
the increases in isc induced by tachykinins were not modified by prior tissue incubation with phentolamine , propranolol , atropine , tetrodotoxin , or indomethacin , but were effectively inhibited by ( d-pro2 , d-trp7,9 ) substance p . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
32,
43
]
} | {
"id": "C0038585",
"name": "substance",
"pos": [
223,
232
]
} |
s. pneumoniae reduced pmn elastase activity by 48 % , whereas the other 3 species tested had only minimal effects on elastase activity . | NA | {
"id": "C0064833",
"name": "pmn",
"pos": [
22,
25
]
} | {
"id": "C0030306",
"name": "elastase",
"pos": [
117,
125
]
} |
the surfactant used in this study ( ta surfactant ) contains only the low molecular weight ( 6 kda ) surfactant proteins and not the 35 kda surfactant protein . | NA | {
"id": "C0072600",
"name": "surfactant proteins",
"pos": [
101,
120
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
151,
158
]
} |
no differences were evident in the concentrations of surfactant proteins between the 2 groups by day 3 , nor were differences evident between the 2 groups evident for 35 kda surfactant protein during the first 3 days of life . | NA | {
"id": "C0072600",
"name": "surfactant proteins",
"pos": [
53,
72
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
185,
192
]
} |
increased low molecular weight surfactant proteins in tracheal aspirates 1 to 2 days after surfactant therapy may occur either because of persistence of exogenous surfactant proteins and/or enhanced surfactant protein production . | NA | {
"id": "C0072600",
"name": "surfactant proteins",
"pos": [
31,
50
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
210,
217
]
} |
the design of immunogens for raising antisera containing antibodies specifically directed against paracetamol is discussed . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
37,
45
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
57,
67
]
} |
ten trauma patients and 13 burns patients were studied intensively for the first 36 h and subsequent 6 days post injury in order to investigate the mechanism of trauma and burn associated proteinuria . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
4,
10
]
} | {
"id": "C0006434",
"name": "burn",
"pos": [
172,
176
]
} |
burns patient 's initial maximum proteinuria occurred between 4 and 8 h post injury , whilst trauma patients showed greatest proteinuria within 4 h . | NA | {
"id": "C0006434",
"name": "burns",
"pos": [
0,
5
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
93,
99
]
} |
five acute phase proteins ( alpha 1-antitrypsin , alpha 1-antichymotrypsin , orosomucoid , haptoglobin and c-reactive protein ) and the esr were measured in 171 patients presenting to the gastroenterologists ( gastrointestinal disease : 130 , other disease : 41 ) . | NA | {
"id": "C0001347",
"name": "acute",
"pos": [
5,
10
]
} | {
"id": "C0002191",
"name": "alpha 1-antitrypsin",
"pos": [
28,
47
]
} |
five acute phase proteins ( alpha 1-antitrypsin , alpha 1-antichymotrypsin , orosomucoid , haptoglobin and c-reactive protein ) and the esr were measured in 171 patients presenting to the gastroenterologists ( gastrointestinal disease : 130 , other disease : 41 ) . | NA | {
"id": "C0001347",
"name": "acute",
"pos": [
5,
10
]
} | {
"id": "C0002190",
"name": "alpha 1-antichymotrypsin",
"pos": [
50,
74
]
} |
five acute phase proteins ( alpha 1-antitrypsin , alpha 1-antichymotrypsin , orosomucoid , haptoglobin and c-reactive protein ) and the esr were measured in 171 patients presenting to the gastroenterologists ( gastrointestinal disease : 130 , other disease : 41 ) . | NA | {
"id": "C0001347",
"name": "acute",
"pos": [
5,
10
]
} | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
77,
88
]
} |
five acute phase proteins ( alpha 1-antitrypsin , alpha 1-antichymotrypsin , orosomucoid , haptoglobin and c-reactive protein ) and the esr were measured in 171 patients presenting to the gastroenterologists ( gastrointestinal disease : 130 , other disease : 41 ) . | NA | {
"id": "C0001347",
"name": "acute",
"pos": [
5,
10
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
91,
102
]
} |
five acute phase proteins ( alpha 1-antitrypsin , alpha 1-antichymotrypsin , orosomucoid , haptoglobin and c-reactive protein ) and the esr were measured in 171 patients presenting to the gastroenterologists ( gastrointestinal disease : 130 , other disease : 41 ) . | NA | {
"id": "C0001347",
"name": "acute",
"pos": [
5,
10
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
107,
125
]
} |
assessment of the sensitivity and specificity of the proteins and the esr showed alpha 1-antichymotrypsin to be the most sensitive test ( 95 % ) with specificity ( 81 % ) similar to the other acute phase proteins measured . | NA | {
"id": "C0002190",
"name": "alpha 1-antichymotrypsin",
"pos": [
81,
105
]
} | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
192,
212
]
} |
a csf index for apo e and apo a-1 was calculated in the same manner presently used for calculation of immunoglobulin g ( igg ) production in the nervous system of patients with multiple sclerosis ( ms ) . | NA | {
"id": "C0003592",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0085201",
"name": "apo a-1",
"pos": [
26,
33
]
} |
the results showed that the concentrations of apo e , apo al , and albumin in the csf of the ms patients were not significantly altered . | NA | {
"id": "C0003595",
"name": "apo e",
"pos": [
46,
51
]
} | {
"id": "C0003591",
"name": "apo",
"pos": [
54,
57
]
} |
the difference was relatively specific for serum apo e because the serum apo al and albumin concentrations were unchanged . | NA | {
"id": "C0003595",
"name": "apo e",
"pos": [
49,
54
]
} | {
"id": "C0003591",
"name": "apo",
"pos": [
73,
76
]
} |
an important non-protein toxin is lipopolysaccharide or endotoxin , which is a constituent of the cell wall of gram negative bacteria . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
34,
52
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
56,
65
]
} |
report of a case of hirschsprung 's disease associated with meckel 's diverticulum , gall stones and trisomy 21 , in an 18 year old woman , operated for a bowel obstruction due to a volvulus secondary to bowel distention . | NA | {
"id": "C0021843",
"name": "bowel obstruction",
"pos": [
155,
172
]
} | {
"id": "C0042961",
"name": "volvulus",
"pos": [
182,
190
]
} |
blood samples were collected serially and analysed by electron capture gas-liquid chromatography for d-f and its main metabolite , d-norfenfluramine ( d-nf ) . | NA | {
"id": "C0015827",
"name": "d-f",
"pos": [
101,
104
]
} | {
"id": "C0028362",
"name": "norfenfluramine",
"pos": [
133,
148
]
} |
as in the case of d-f the elimination t1/2 of d-nf was also longer in zucker than sprague-dawley rats . | NA | {
"id": "C0015827",
"name": "d-f",
"pos": [
18,
21
]
} | {
"id": "C0028362",
"name": "d-nf",
"pos": [
46,
50
]
} |
inter- and intra-strain differences in d-f and d-nf kinetics should be considered in neurochemical studies of the drug and extrapolation of data across animal species requires consideration of dose dependence in the rat . | NA | {
"id": "C0015827",
"name": "d-f",
"pos": [
39,
42
]
} | {
"id": "C0028362",
"name": "d-nf",
"pos": [
47,
51
]
} |
two mixed bacterial cultures isolated by soil enrichment were capable of utilizing methyl parathion ( o , o-dimethyl o-p-nitrophenylphosphorothioate ) and parathion ( o , o-diethyl o-p-nitrophenylphosphorothioate ) as a sole source of carbon . | NA | {
"id": "C0025709",
"name": "methyl parathion",
"pos": [
83,
99
]
} | {
"id": "C0030514",
"name": "parathion",
"pos": [
155,
164
]
} |
at a fixed temperature , the optimal concentration of polyamine analogs was in the order diamines greater than triamines greater than tetraamines greater than pentaamines . | NA | {
"id": "C0032433",
"name": "polyamine",
"pos": [
54,
63
]
} | {
"id": "C0011957",
"name": "diamines",
"pos": [
89,
97
]
} |
effects of anions , ca2+ , mg2+ , and aliphatic alcohols on the reaction of hemocyanin with cyanide . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
11,
17
]
} | {
"id": "C0010505",
"name": "cyanide",
"pos": [
92,
99
]
} |
the reaction between carcinus maenas hemocyanin and cyanide has been used for probing protein conformation in the presence of perturbants such as various anions , cations ( ca2+ , mg2+ ) , and aliphatic alcohols . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
52,
59
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
154,
160
]
} |
the inhibitor specifically blocked the action of the two calcium-dependent proteases , cdp-i and cdp-ii , but did not influence a variety of other proteases including trypsin , chymotrypsin , or staphylococcus aureus v8 protease . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
75,
84
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
220,
228
]
} |
the reaction between metmyoglobin and h2o2 proceeds with oxidation of the hemo-protein iron to a higher valence state and consumption of the peroxide . | NA | {
"id": "C0020281",
"name": "h2o2",
"pos": [
38,
42
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
141,
149
]
} |
purification and identification of two serine class proteinases from dog mast biochemically and immunologically similar to human proteinases tryptase and chymase . | NA | {
"id": "C2717971",
"name": "serine",
"pos": [
39,
45
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
129,
140
]
} |
these studies establish the presence of a trypsin-like and chymotrypsin-like proteinase in dog skin mast cells and provide immunological evidence which suggests that both proteinases are more closely related to human than rat mast cell proteinases . | NA | {
"id": "C0030946",
"name": "proteinase",
"pos": [
77,
87
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
236,
247
]
} |
the flavoprotein nitroreductases nadph : cytochrome p-450 reductase and xanthine oxidase catalyzed the cofactor-dependent anaerobic nitro group reduction and covalent binding to protein sulfhydryl groups of the 5-nitroimidazole substrate ronidazole [ 1-methyl-5-nitroimidazole-2-yl ) -methyl carbamate ) . | NA | {
"id": "C0035839",
"name": "ronidazole",
"pos": [
238,
248
]
} | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
262,
276
]
} |
using immune complexes of horseradish peroxidase ( hrp ) and rabbit igg antibodies to hrp , the receptors were localized to the outer aspect of the keratinocytes and to the inflammatory cells in the microabscesses . | NA | {
"id": "C0003313",
"name": "immune",
"pos": [
6,
12
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
72,
82
]
} |
in this study 16 patients with ra were given 540 mg gla/day ( epo ) , 15 patients 240 mg epa and 450 mg gla/day ( epo/fish oil ) , and 18 patients an inert oil ( placebo ) . | NA | {
"id": "C0016157",
"name": "fish",
"pos": [
118,
122
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
156,
159
]
} |
seventy-four israeli patients with rheumatoid arthritis ( ra ) were studied for possible association between hla antigens and adverse reactions to gold treatment ( aurothioglucose ) . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
147,
151
]
} | {
"id": "C0018033",
"name": "aurothioglucose",
"pos": [
164,
179
]
} |
this decrease in serum proteins and rise in lymph proteins parallels similar results after albumin resuscitation in man and animals and suggests that hespan induces an oncotically controlled extravascular protein relocation . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
91,
98
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
205,
212
]
} |
leucine flux and oxidation were significantly ( p less than 0.01 , by paired t-test ) elevated with bcaa feeding as compared to the egg protein formulation . | NA | {
"id": "C0023401",
"name": "leucine",
"pos": [
0,
7
]
} | {
"id": "C0002521",
"name": "bcaa",
"pos": [
100,
104
]
} |
it appears from these results that the major consequences of increased intake of leucine from the bcaa formula is an enhanced rate of leucine oxidation . | NA | {
"id": "C0002521",
"name": "bcaa",
"pos": [
98,
102
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
134,
141
]
} |
respiratory tract infection occurred in each of the recipients who died with infection , and the same organisms appeared to be related to subsequent mediastinitis in 3 patients ( serratia marcescens , 2 ; pseudomonas , 1 ) and caused fatal sepsis in another ( enterobacter aerogenes , candida albicans ) . | NA | {
"id": "C0035243",
"name": "respiratory tract infection",
"pos": [
0,
27
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
77,
86
]
} |
hypothyroidism complicated by spontaneous hyperthyroidism is an interesting but rare occurrence in the spectrum of autoimmune thyroid disorders . | NA | {
"id": "C0020676",
"name": "hypothyroidism",
"pos": [
0,
14
]
} | {
"id": "C0040128",
"name": "of",
"pos": [
112,
114
]
} |
hypothyroidism complicated by spontaneous hyperthyroidism is an interesting but rare occurrence in the spectrum of autoimmune thyroid disorders . | NA | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
42,
57
]
} | {
"id": "C0040128",
"name": "of",
"pos": [
112,
114
]
} |
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