text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these findings indicate that the chicken receptor correctly traverses the endocytic pathway in a rat cell even though the cytoplasmic domain of this protein shows no primary structural homology with the corresponding portion of the rat liver receptor or with receptors found in fibroblasts . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
278,
289
]
} |
clathrin light chains , lca and lcb , are products of two closely related genes whose mrnas undergo differential splicing to result in at least four different light chain isoforms . | NA | {
"id": "C0033684",
"name": "products",
"pos": [
42,
50
]
} | {
"id": "C0597298",
"name": "isoforms",
"pos": [
171,
179
]
} |
location of fatty acids in lipid a obtained from lipopolysaccharide of rhodopseudomonas sphaeroides atcc 17023 . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
27,
34
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
49,
67
]
} |
syrian hamster embryo fibroblasts transformed by 4-nitroquinoline-1-oxide ( nqt-she cells ) failed to synthesize the pro-alpha 1 ( i ) subunit of type i procollagen but continued to synthesize altered forms of the other subunit , pro-alpha 2 ( i ) ( peterkofsky , b. , and prather , w. ( 1986 ) j. biol . chem . 261 , 16818-16826 ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
22,
33
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
84,
89
]
} |
using forms of beta-leucine and leucine that contain several deuterium atoms in place of several hydrogen atoms as internal standards , techniques have been developed which make it possible to detect and quantitate as little as 0.1 mumol/liter of beta-leucine or leucine in human serum and in incubations containing rat liver supernatant . beta-leucine was not detectable , i.e . less than 0.1 mumol/liter , in any sera from 50 normal human subjects or in any sera from 50 cobalamin-deficient patients . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
61,
70
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
97,
105
]
} |
facilitation of hb s polymerization by the substitution of glu for gln at beta 121 . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
59,
62
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
67,
70
]
} |
in an effort to clarify the role of glu-beta 121 of hb s molecules in polymerization , we studied the solubility and kinetics of polymerization of various mixtures of deoxyhemoglobins s ( glu-beta 6 -- -- val ) and d los angeles ( glu-beta 121 -- -- gln ) . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
36,
39
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
250,
253
]
} |
the critical concentration for the polymerization of hb d los angeles was between that of hb a and hb machida , which has the same amino acid substitution ( glu -- -- gln ) at the beta 6 position . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
157,
160
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
167,
170
]
} |
the substitution of glu-beta 121 -- -- gln may strengthen this second reaction and facilitate nucleation as well as polymerization . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
20,
23
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
39,
42
]
} |
the rate of enzymatic decay followed first order kinetics with half-lives of 1.1 and 4.0 min for the mutants with ala-328 and lys-328 in 10 % and 5 % glycerol , respectively , while the wild type enzyme was stable even in the absence of glycerol . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
49,
57
]
} | {
"id": "C0018517",
"name": "half-lives",
"pos": [
63,
73
]
} |
the protection afforded by pma was most effective when the cells were pretreated with this phorbol ester , but it decreased when pma was added together with tnf or after tnf addition . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
91,
104
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
129,
132
]
} |
in order to assess the basis for the regulatory effects of the protein matrix on the processing of glycans in glycoproteins , we have used the avidin-biotinylglycan neoglycoprotein model system to compare the kinetic parameters for three rat liver golgi enzymes acting on their free and protein-bound glycan substrates . | NA | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
110,
123
]
} | {
"id": "C0004434",
"name": "avidin",
"pos": [
143,
149
]
} |
since many of the virb gene products have secretion signals common to exported bacterial proteins , it is likely that they will be membrane-associated . | NA | {
"id": "C0033684",
"name": "gene products",
"pos": [
23,
36
]
} | {
"id": "C0004627",
"name": "bacterial proteins",
"pos": [
79,
97
]
} |
the absolute rate of collagen production was decreased by 50 % in the presence of 1.2 nm tnf alpha during 24-h incubations ( 851 +/- 104 versus 426 +/- 39 pmol/micrograms of dna/h ; p less than 0.01 ) , whereas noncollagen protein production and the rate of procollagen secretion were unchanged . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
21,
29
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
258,
269
]
} |
the peptide from hepatoma hydrolase was phosphorylated predominantly at the x , while the peptide y was the major phosphopeptide in the hydrolase of normal liver . | NA | {
"id": "C0030940",
"name": "peptide",
"pos": [
4,
11
]
} | {
"id": "C0020289",
"name": "hydrolase",
"pos": [
136,
145
]
} |
analysis of phosphoamino acids revealed two sites , phosphoserine and phosphothreonine . beta-glucuronidase from hepatoma consisted of a major subunit with molecular mass of 64,000 ( 64 kda ) and a minor subunit with 76 kda , whereas the hydrolase from normal liver had almost exclusively 64 kda subunit . | NA | {
"id": "C0524823",
"name": "phosphoamino acids",
"pos": [
12,
30
]
} | {
"id": "C0031721",
"name": "phosphoserine",
"pos": [
52,
65
]
} |
analysis of phosphoamino acids revealed two sites , phosphoserine and phosphothreonine . beta-glucuronidase from hepatoma consisted of a major subunit with molecular mass of 64,000 ( 64 kda ) and a minor subunit with 76 kda , whereas the hydrolase from normal liver had almost exclusively 64 kda subunit . | NA | {
"id": "C0524823",
"name": "phosphoamino acids",
"pos": [
12,
30
]
} | {
"id": "C0031724",
"name": "phosphothreonine",
"pos": [
70,
86
]
} |
northern analysis revealed that the 5 ' probe hybridizes to a single 1.7-kilobases ( kb ) mrna species , whereas the 3 ' probe hybridizes to two mrna species of 1.7 kb and 5 kb , which are present in many cells including chondrocytes , crop cells , and fibroblasts . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
221,
233
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
241,
246
]
} |
northern analysis revealed that the 5 ' probe hybridizes to a single 1.7-kilobases ( kb ) mrna species , whereas the 3 ' probe hybridizes to two mrna species of 1.7 kb and 5 kb , which are present in many cells including chondrocytes , crop cells , and fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
205,
210
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
253,
264
]
} |
we report now that hb f inhibits in vitro crystallization of hbo2 and hbco c when compared to the effect of hb a in a wide range of mixture proportions . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
19,
23
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
108,
110
]
} |
for example , while hbco c solutions form tetragonal c crystals within 25 min , no crystals form within 2 h with 30 % hb f , whereas 550 crystals/mm3 form with 30 % hb a . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
118,
122
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
165,
167
]
} |
by comparing the sequences of the three inhibitory hemoglobins , we conclude that position gln-87 in the gamma chains is , at least partially , the cause of the inhibitory effect of hb f on the crystallization of hb c . | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
51,
62
]
} | {
"id": "C0015936",
"name": "hb f",
"pos": [
182,
186
]
} |
in protein solutions acidic to the isoelectric point the presence of the positively charged albumin did not alter the corrosion rates as compared to that in saline . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
3,
10
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
92,
99
]
} |
the nickel/chromium ratio in the albumin and gamma globulin solutions was increased relative to that predicted indicating preferential release of nickel in protein solutions . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
33,
40
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
156,
163
]
} |
the results of arthroplasty of the hip and other surgical procedures that were performed in nine patients who had sickle-cell disease or sickle-cell trait and osteonecrosis of the femoral head were not very satisfactory . | NA | {
"id": "C0002895",
"name": "sickle-cell disease",
"pos": [
114,
133
]
} | {
"id": "C0037054",
"name": "sickle-cell trait",
"pos": [
137,
154
]
} |
in reviewing the literature , we classified the tumors according to three subgroups : parosteal ( juxtacortical ) osteosarcoma , periosteal osteosarcoma , and high-grade surface osteosarcoma . | NA | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
114,
126
]
} | {
"id": "C0206642",
"name": "periosteal",
"pos": [
129,
139
]
} |
southern blot hybridization with ras-specific probes revealed that dna from both primary tumors and metastases induced by as tumor dna contained highly amplified ha-ras oncogene . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
67,
70
]
} | {
"id": "C0012930",
"name": "tumor dna",
"pos": [
125,
134
]
} |
heparan sulfate ( hs ) proteoglycan is a major constituent of endothelial basement membranes , and we have found that hs-degradative activities of metastatic b16 melanoma sublines correlate with their lung-colonizing potentials . | NA | {
"id": "C0062503",
"name": "heparan sulfate",
"pos": [
0,
15
]
} | {
"id": "C0019143",
"name": "hs",
"pos": [
118,
120
]
} |
purified platelet-derived growth factor ( pdgf ) , insulin-like growth factor ( igf-1 ) , transforming growth factor-beta ( tgf beta ) , and epidermal growth factor ( egf ) in combination with tgf beta did not stimulate 3h-thymidine incorporation in hs294t cells under the conditions used for mgsa bioassay . | NA | {
"id": "C0037657",
"name": "insulin-like growth factor",
"pos": [
51,
77
]
} | {
"id": "C0021665",
"name": "igf-1",
"pos": [
80,
85
]
} |
multiple fronts were formed when pure liquids such as methanol or heptane and multi-component liquids such as ethanol-toluene mixtures were flowed through initially dry thin-layer chromatography plates , whether the stationary phase was naked silica or octadecyl-silica . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
54,
62
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
110,
117
]
} |
the predicted ris of a number of alicyclic , aliphatic and aromatic hydrocarbons , primary , secondary and tertiary alcohols , phenols , aliphatic amines , aromatic amines , heterocyclics , carboxylic acids , acid esters , aldehydes , ketones , and halogenated compounds , are found to be within +/- 3 % of the observed values . | NA | {
"id": "C0007066",
"name": "carboxylic acids",
"pos": [
190,
206
]
} | {
"id": "C0014898",
"name": "esters",
"pos": [
214,
220
]
} |
these findings suggest that defective cycles occur as a random phenomenon in infertility and no more often than in normal women , and a diagnosis of ld implying a persistent condition to explain prolonged infertility in women with normal menstrual cycles must be a rare entity and requires at least six cycles of investigation ( or none ! ) before treatment is considered . | NA | {
"id": "C0021359",
"name": "infertility",
"pos": [
77,
88
]
} | {
"id": "C0021361",
"name": "infertility",
"pos": [
205,
216
]
} |
hcg was determined by a specific radioimmunoassay which applied an antiserum directed against the hcg-beta subunit . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
0,
3
]
} | {
"id": "C0106132",
"name": "hcg-beta subunit",
"pos": [
98,
114
]
} |
sera and genital secretions of 178 infertile men and 40 infertile women were evaluated for antibodies against spermatozoa by an enzyme-linked immunosorbent assay ( elisa ) . | NA | {
"id": "C0021359",
"name": "infertile",
"pos": [
35,
44
]
} | {
"id": "C0021361",
"name": "infertile women",
"pos": [
56,
71
]
} |
antibody that reacted with enzyme-treated whole cells in rabbit antiserum was absorbed with group a streptococcal whole cells , purified c carbohydrate , and n-acetylglucosamine only . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
64,
73
]
} |
the trajectories and the cells of origin of the pontobulbar gigantocellular tegmental field descending pathways were studied in the cat using anterograde wga-hrp and retrograde hrp techniques . | NA | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
154,
161
]
} | {
"id": "C0019941",
"name": "hrp",
"pos": [
177,
180
]
} |
the afferent and efferent connections of the primary auditory cortex ( ai ) of common marmosets were traced following small injections of wheat germ agglutinin conjugated with horseradish peroxidase ( wga-hrp ) made at best frequency ( bf ) -defined sites in the ai . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
176,
198
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
201,
208
]
} |
intracellular injection of hrp combined with immunocytochemistry for [ leu ] enkephalin was used to demonstrate striatal spiny neuron dendritic and local axonal arborizations in the same section as enkephalin-rich patches ( striosomes ) . | NA | {
"id": "C0014294",
"name": "leu ] enkephalin",
"pos": [
71,
87
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
198,
208
]
} |
inflammatory leukocytes may respond to zymosan because the cells recognize either one or both of its major polysaccharide components , glucan and mannan . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
107,
121
]
} | {
"id": "C0024727",
"name": "mannan",
"pos": [
146,
152
]
} |
the results confirm clinical , radiological , and subjective pathological impressions of the progress of the disease and suggest a central role for ulceration in this disease . | NA | {
"id": "C0030660",
"name": "pathological",
"pos": [
61,
73
]
} | {
"id": "C0041582",
"name": "ulceration",
"pos": [
148,
158
]
} |
the results confirm clinical , radiological , and subjective pathological impressions of the progress of the disease and suggest a central role for ulceration in this disease . | NA | {
"id": "C0030660",
"name": "pathological",
"pos": [
61,
73
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
167,
174
]
} |
furthermore , the immunoreactivity of soluble proteins , such as albumin , remained unaltered in immunoblots obtained from paraffin-embedded mouse liver sections . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
46,
54
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
65,
72
]
} |
in cultures maximally stimulated by erythropoietin and human placental conditioned medium , depletion of 25e11+ cells from beta-thalassemic pbmc resulted in up to a fourfold enhancement of multi-potential and pure erythroid colonies and a twofold enhancement of non-erythroid colonies when compared with c-only treated cells . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
140,
144
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
319,
324
]
} |
the t cell repertoires for self insulin appear to be similar in diabetics and non-diabetics based on their patterns of t cell reactivity to beef insulin , port insulin , human insulin , and various peptide of human insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
32,
39
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
209,
222
]
} |
hiv-1-infected cells , but not uninfected cells , were found to be lysed to a greater extent by pbl in the presence of the gp110 x cd3 or the gp110 x cd16 antibody heteroconjugate than in the presence of the single antibodies or a mixture of the mab comprising the heteroconjugates . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
155,
163
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
246,
249
]
} |
we used in vitro cultures of highly enriched hematopoietic progenitor cells stimulated by natural and recombinant growth factors to investigate the biologic effects of tgf beta 1 and tgf beta 2 on erythroid ( cfu-e and burst-forming unit ( bfu ) -e ) , granulocyte-macrophage ( cfu-gm ) and multilineage ( i.e. , granulocyte , erythroid , macrophage , and megakaryocyte ; cfu-gemm ) colony-forming cells . | NA | {
"id": "C0018956",
"name": "hematopoietic progenitor",
"pos": [
45,
69
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
398,
403
]
} |
[ 35s ] methionine-labeled ii and associated molecules were immunoprecipitated with a mab to native ii and then denatured , resolubilized , and subjected to a second immunoprecipitation with various antibodies . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
86,
89
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
199,
209
]
} |
two antisera to c-terminal peptides of ii ( 183 to 193 and 192 to 211 ) , but not antibodies to an n-terminal peptide ( 12 to 28 ) , did immunoprecipitate p25 . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
4,
12
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
82,
92
]
} |
these results therefore demonstrate that the pbmc from patients with visceral leishmaniasis contain a population of cells that are capable of suppressing the il-2 production by autologous pbmc from recovered patients . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
116,
121
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
188,
192
]
} |
a rapid and simple elisa for the determination of duplicate monoclonal antibodies during epitope analysis of antigens and its application to the study of c1 ( - ) -inh . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
89,
96
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
109,
117
]
} |
the method utilizes microtiter plates coated with one of the monoclonal antibodies either by direct adsorption of the purified antibody to the plastic or by immobilization of the antibody from ascites or hybridoma supernatants via immobilized polyclonal anti-mouse immunoglobulin antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
61,
82
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
179,
187
]
} |
binding of antigen to the first antibody is only observed when the second monoclonal antibody binds to a distinct epitope . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
32,
40
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
74,
93
]
} |
some mabs that reacted with antigen that was adsorbed to a polystyrene well would not bind to antigen that was presented in a more natural configuration , as in the case of antigen immobilized by trapping antibody . | NA | {
"id": "C0003250",
"name": "mabs",
"pos": [
5,
9
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
205,
213
]
} |
conversely , mabs that reacted with antigen that was immobilized by another antibody did not all function as trapping antibodies when adsorbed directly to a polystyrene surface . | NA | {
"id": "C0003250",
"name": "mabs",
"pos": [
13,
17
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
118,
128
]
} |
the specimens comprised 21 pleomorphic adenomas , 3 monomorphic adenomas , 25 adenolymphomas , 5 mucoepidermoid carcinomas , 3 acinic cell tumours , 8 adenoid cystic carcinomas , 2 adenocarcinomas and 8 undifferentiated carcinomas . | NA | {
"id": "C0206694",
"name": "mucoepidermoid carcinomas",
"pos": [
97,
122
]
} | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
181,
196
]
} |
the specimens comprised 21 pleomorphic adenomas , 3 monomorphic adenomas , 25 adenolymphomas , 5 mucoepidermoid carcinomas , 3 acinic cell tumours , 8 adenoid cystic carcinomas , 2 adenocarcinomas and 8 undifferentiated carcinomas . | NA | {
"id": "C0010606",
"name": "adenoid cystic carcinomas",
"pos": [
151,
176
]
} | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
181,
196
]
} |
dibutyryl camp ( dbcamp ) , a stable analogue of camp , increased calmodulin levels and camp phosphodiesterase activity . | NA | {
"id": "C0012054",
"name": "dibutyryl camp",
"pos": [
0,
14
]
} | {
"id": "C0001455",
"name": "camp",
"pos": [
88,
92
]
} |
two molecular variants of plasminogen activator ( pa ) : urokinase ( upa ) and tissue-type plasminogen activator ( tpa ) , have been reported to be synthesized in the rat testis . | NA | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
26,
47
]
} | {
"id": "C0032143",
"name": "tissue-type plasminogen activator",
"pos": [
79,
112
]
} |
the red cell adrenoceptor affinity for the unspecific agonists adrenaline and noradrenaline and the specific beta-agonist isoprenaline was studied in vitro on whole blood of rainbow trout , salmo gairdneri at 15 degrees c . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
63,
73
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
78,
91
]
} |
the erythrocytic adrenoceptors could be pharmacologically characterized as beta-receptors of the 'noradrenaline'-type ( beta 1-type ) , with an order of potency of isoprenaline greater than noradrenaline much greater than adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
98,
111
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
222,
232
]
} |
the adrenoceptor affinities , expressed as agonist concentrations for 50 % response ( ec50 ) , were 1.3 x 10 ( -8 ) and 7.6 x 10 ( -7 ) mol l-1 for noradrenaline and adrenaline , respectively . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
148,
161
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
166,
176
]
} |
thus , the anti-tbm b cell compartment in bn rats is moderately large , but is primarily focused to a single epitope on the nephritogenic antigen and is associated with a disease-modifying crossreactive idiotype . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
109,
116
]
} | {
"id": "C0021013",
"name": "idiotype",
"pos": [
203,
211
]
} |
interleukin-hp1 ( hp1 ) /il-6 is a 25-30-kd protein produced by macrophages , fibroblasts , and certain t cell lines . | NA | {
"id": "C0021764",
"name": "interleukin",
"pos": [
0,
11
]
} | {
"id": "C0021760",
"name": "il-6",
"pos": [
25,
29
]
} |
after mixed lymphocyte culture with irradiated allogeneic cells for 7 d and 3 additional days in ril-2 ( 100 u/ml ) , cells underwent proliferation in three of five individuals tested . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
47,
63
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
118,
123
]
} |
in addition , mlc-derived cells lysed 51cr-labeled pha-induced blasts derived from the allogeneic cells used as stimulator , but not allogeneic unrelated or autologous blast cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
26,
31
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
87,
103
]
} |
no cytotoxicity against autologous or allogeneic target cells could be induced by culturing cd3+4-8-wt31- lymphocytes in mlc with irradiated autologous cells . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
38,
48
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
152,
157
]
} |
recombinants containing both the first and second atg initiation codons of the hantaan virus gene produced nucleocapsid protein , while those containing only the second codon did not . | NA | {
"id": "C0242610",
"name": "initiation codons",
"pos": [
54,
71
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
169,
174
]
} |
the occurrence of diurnal rhythmicity in tissue norepinephrine ( ne ) , epinephrine ( e ) and dopamine ( da ) levels of rat thyroid and submaxillary glands was assessed in animals killed at eight time intervals during a 24 hour period . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
48,
62
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
72,
83
]
} |
immunohistochemical studies after ox 8 or ox 19 treatment showed a complete absence of staining for the respective antibodies , while staining was preserved with the other mca . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
115,
125
]
} | {
"id": "C0003250",
"name": "mca",
"pos": [
172,
175
]
} |
a prospective randomized phase iii trial comparing combination chemotherapy with cyclophosphamide , fluorouracil , and either doxorubicin or epirubicin . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
126,
137
]
} | {
"id": "C0014582",
"name": "epirubicin",
"pos": [
141,
151
]
} |
three primary antibodies were used : polyclonal antisera raised against fragments of substance p and substance k that excluded the carboxyl termini of these peptides , and a monoclonal antibody that recognized the carboxyl terminus of the tachykinin family . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
14,
24
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
48,
56
]
} |
three primary antibodies were used : polyclonal antisera raised against fragments of substance p and substance k that excluded the carboxyl termini of these peptides , and a monoclonal antibody that recognized the carboxyl terminus of the tachykinin family . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
14,
24
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
174,
193
]
} |
three primary antibodies were used : polyclonal antisera raised against fragments of substance p and substance k that excluded the carboxyl termini of these peptides , and a monoclonal antibody that recognized the carboxyl terminus of the tachykinin family . | NA | {
"id": "C0038585",
"name": "substance",
"pos": [
85,
94
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
239,
249
]
} |
three primary antibodies were used : polyclonal antisera raised against fragments of substance p and substance k that excluded the carboxyl termini of these peptides , and a monoclonal antibody that recognized the carboxyl terminus of the tachykinin family . | NA | {
"id": "C0038581",
"name": "substance k",
"pos": [
101,
112
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
239,
249
]
} |
a monoclonal antibody that recognizes the carboxyl terminus of substance p was used to localize tachykinin-like immunoreactivity in neurons of area 17 of the adult monkey cerebral cortex . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
63,
74
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
96,
106
]
} |
feeding of purified diets containing fish oil without added antioxidant leads to rapid autoxidation of the oil and the possibility of artifactual results due to the feeding of autoxidation products . | NA | {
"id": "C0016157",
"name": "fish oil",
"pos": [
37,
45
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
107,
110
]
} |
the effects of excess leucine intake on food intake , branched-chain amino acid and branched-chain alpha-keto acid concentrations in plasma and nitrogen retention were investigated in the preruminant lamb . | NA | {
"id": "C0023401",
"name": "leucine",
"pos": [
22,
29
]
} | {
"id": "C0002521",
"name": "branched-chain amino acid",
"pos": [
54,
79
]
} |
in addition , the animals with immune synovitis showed abortive cartilage repair exemplified by the presence of chondrocyte cloning ( up to 20 cells ) which correlated with increased fitc-mab 2g2 staining . | NA | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
112,
123
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
143,
148
]
} |
in the past this syndrome has been confused with other overgrowth disorders such as neurofibromatosis , klippel-trenaunay-weber syndrome , maffucci syndrome , and bannayan syndrome . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
17,
25
]
} | {
"id": "C0012634",
"name": "disorders",
"pos": [
66,
75
]
} |
single-stranded virion dna was found in other organs , but the strand-specific probes made it possible to show that this dna represented virus sequestration . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
0,
15
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
121,
124
]
} |
the geometric mean titer of serum neutralizing antibody to a reassortant virus ( cjn-m ) that contained vp7 of cjn and vp3 of another human rotavirus was 12.7 times less than that of antibody to cjn before infection and 20.3 times less after infection . | NA | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
34,
55
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
183,
191
]
} |
by using the antisera the stabilities of the dna polymerase , the alkaline nuclease , and the major dna-binding protein were determined , and the state of phosphorylation of the dna polymerase was compared with each of these proteins . | NA | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
100,
119
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
225,
233
]
} |
after limited proteinase k digestion , three prp-immunoreactive proteins with apparent molecular masses ranging between 20 and 30 kilodaltons were detected in extracts of scrapie-infected n2a cells by western ( immuno- ) blotting . | NA | {
"id": "C0033164",
"name": "prp",
"pos": [
45,
48
]
} | {
"id": "C0033684",
"name": "prp",
"pos": [
45,
48
]
} |
this monoclonal antibody differed in receptor epitope specificity from a previously isolated antibody ( rmca ) ( r . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
5,
24
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
93,
101
]
} |
viral rna containing the largest deletion ( r1 ) replicated approximately three times better than full-length rna produced in vitro . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
0,
9
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
110,
113
]
} |
analysis by immunoprecipitation of viral proteins induced after transfection of r1 rna into hela cells revealed the presence of proteins 2apro , 2c , and 3dpol and its precursors , suggesting that the polyprotein cleavages are similar to those occurring in virus-infected cells . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
35,
49
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
128,
136
]
} |
to understand how srv-1 infection relates to the immune defect , we studied in vivo-infected lymphocytes from srv-1-positive macaques with and without clinical signs of immunosuppressive disease . | NA | {
"id": "C0039082",
"name": "srv-1",
"pos": [
18,
23
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
187,
194
]
} |
in vitro infection studies were also done with hut78 , h9 , k562 , rhesus lung fibroblast , rhesus monkey kidney , and bat lung cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
79,
89
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
128,
133
]
} |
the observed effects of anti-mu treatment may reflect the action of neutralizing antibodies ( which so far have been difficult to demonstrate in vivo ) or other antibody-dependent antiviral mechanisms which , together with t cells , efficiently control lcmv clearance . | NA | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
68,
91
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
161,
169
]
} |
insertion of a synthetic dna fragment encoding a poliovirus neutralization epitope into the s gene encoding the major envelope protein of hepatitis b virus has yielded hybrid ( hbspolioag ) particles closely resembling authentic 22-nm antigen ( hbsag ) particles by expression of the modified gene in mammalian cells . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
75,
82
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
235,
242
]
} |
the majority of mutants were also resistant against five strain-specific nt-mabs which recognized conformation-dependent epitopes , suggesting that the neutralization antigenic site i must be involved in the formation of such epitopes . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
167,
176
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
226,
234
]
} |
the serum level of the squamous cell carcinoma-related antigen ( scc-ag ) has been measured by a new immunoradiometric assay ( irma ) method that has been recently developed by using a monoclonal antibody , and compared with the results obtained by the conventional double-antibody method using a polyclonal antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
185,
204
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
308,
316
]
} |
glioblastoma showed higher values of area and peak , whereas astrocytomas showed lower values when compared to those found in normal gray matter . | NA | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
0,
12
]
} | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
61,
73
]
} |
an ultrasonogram revealed that the tumors had the shape of a clear-margined anechoic mass like a cyst . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
35,
41
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
97,
101
]
} |
urinary glycosaminoglycan excretion was normal but tlc of urinary oligosaccharides revealed an abnormal band with the mobility of a disaccharide . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
66,
82
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
132,
144
]
} |
further purification of this compound revealed two disaccharides , both of which yielded mannose and glucosamine following acid hydrolysis and mannose and n-acetylglucosamine following enzymic digestion . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
101,
112
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
155,
174
]
} |
phorbol ester tumor promoter , such as 12-o-tetradecanoylphorbol-13-acetate ( tpa ) , is synergistic with dexamethasone to cause growth inhibition of cem-c7 human t-leukemia cell line . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
0,
13
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
39,
75
]
} |
based on the known normal distribution of differentiation antigens , particularly the cd-13 antigen , cases could be ranked according to clonogenic phenotype into immature ( cd-13- hla-dr+ cd-33+ or cd-33- ; five cases ) , and mature ( cd-13+ hla-dr+ cd-33+ ; eight cases ) , levels . | NA | {
"id": "C0003324",
"name": "differentiation antigens",
"pos": [
42,
66
]
} | {
"id": "C0003322",
"name": "cd",
"pos": [
251,
253
]
} |
furthermore , in anll the effects of fc are dependent upon the stage of the disease . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
3,
6
]
} | {
"id": "C0016030",
"name": "fc",
"pos": [
37,
39
]
} |
in the same animals endogenous putrescine plasma levels did not differ significantly between spermidine- or saline-infused animals , whereas endogenous cadaverine levels increased during spermidine infusion and decreased afterwards . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
31,
41
]
} | {
"id": "C0037871",
"name": "infusion",
"pos": [
198,
206
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.