text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
after excluding infections , this simple , rapid , reproducible , and non-invasive technique provides reliable information in distinguishing glomerular bleeding from other causes of haematuria . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
152,
160
]
} | {
"id": "C0018965",
"name": "haematuria",
"pos": [
182,
192
]
} |
a 3.1-kb intergenic dna fragment located between the psi beta-globin and delta-globin genes in the beta-globin gene cluster was cloned from gorilla , orangutan , rhesus monkey , and spider monkey , and the nucleotide sequence of each fragment was determined . | NA | {
"id": "C0011244",
"name": "delta-globin",
"pos": [
73,
85
]
} | {
"id": "C0005221",
"name": "globin",
"pos": [
104,
110
]
} |
low passage-number cultured chinese hamster cells were used to assess the ability of four benzodiazepines , namely diazepam , medazepam , midazolam and bromazepam , to induce numerical and structural chromosome aberrations . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
90,
105
]
} | {
"id": "C0025051",
"name": "medazepam",
"pos": [
126,
135
]
} |
low passage-number cultured chinese hamster cells were used to assess the ability of four benzodiazepines , namely diazepam , medazepam , midazolam and bromazepam , to induce numerical and structural chromosome aberrations . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
90,
105
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
138,
147
]
} |
in this procedure , we measure the output of the label from the liver in two glycoconjugates derived from hepatic udp-glucose , namely , glucuronic acid formed through udp-glucuronic acid and excreted in the urine following acetaminophen administration , and galactose formed through udp-galactose and then secreted in the carbohydrate portion of glycoproteins in the plasma . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
77,
92
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
323,
335
]
} |
in this procedure , we measure the output of the label from the liver in two glycoconjugates derived from hepatic udp-glucose , namely , glucuronic acid formed through udp-glucuronic acid and excreted in the urine following acetaminophen administration , and galactose formed through udp-galactose and then secreted in the carbohydrate portion of glycoproteins in the plasma . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
77,
92
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
347,
360
]
} |
the specific activity in the two glycoconjugates was compared when either [ 1-3h ] galactose or [ u-14c ] glucose was the infused precursor sugar . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
33,
48
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
140,
145
]
} |
in vitro studies indicating an inverse relationship between free fatty acid ( ffa ) availability and glucose oxidation led to proposal of the glucose-fatty acid cycle . | NA | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
60,
75
]
} | {
"id": "C0015684",
"name": "fatty",
"pos": [
150,
155
]
} |
the joint effect of hyperinsulinemia and upper body adiposity on lipids , lipoproteins , and bp , however , has not been previously studied . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
65,
71
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
74,
86
]
} |
we measured bp , lipids and lipoproteins , hdl subfractions , and insulin and glucose concentrations as part of the san antonio heart study , a population-based study of diabetes and cardiovascular risk factors . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
17,
23
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
28,
40
]
} |
monocytes and lymphocytes from three patients and 12 age- and sex-matched controls were incubated at 37 degrees c in lipid-free medium with 125i-labeled ldl prepared from sitosterolemic patients ( ldls ) and controls ( ldln ) in the presence or absence of excess unlabeled lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
117,
122
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
273,
285
]
} |
sitosterolemic monocytes contained three times more sterols and stanols than controls ( p less than .01 ) , of which 12 % were plant sterols and 2 % were 5 alpha-saturated stanols . | NA | {
"id": "C0038323",
"name": "sterols",
"pos": [
52,
59
]
} | {
"id": "C0031866",
"name": "plant sterols",
"pos": [
127,
140
]
} |
in the non-insulin-dependent diabetes mellitus ( stz-niddm ) group , no clear reciprocal relationship between irc-p and glucose and irg was obtained . | NA | {
"id": "C0011849",
"name": "non-insulin-dependent diabetes mellitus",
"pos": [
7,
46
]
} | {
"id": "C0011860",
"name": "niddm",
"pos": [
53,
58
]
} |
and ( 2 ) the inhibitory effect of glucose was blocked in cells preincubated in medium containing either the sulfonylurea glyburide , or d-myo-inositol . | NA | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
109,
121
]
} | {
"id": "C0017628",
"name": "glyburide",
"pos": [
122,
131
]
} |
british columbia coastal indians possess abnormal patterns of essential fatty acid ( efa ) and prostaglandin ( pge ) metabolism as racially determined genetic traits , probably a consequence of evolving for tens of thousands of years on a diet extremely rich in efa 's . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
95,
108
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
111,
114
]
} |
the covalent binding of [ 125i ] cgp-23996 to gh3 and att-20 cell membranes was blocked by 1 microm srif , somatostatin 28 , trp8-srif and was gtp sensitive . | NA | {
"id": "C0074854",
"name": "somatostatin 28",
"pos": [
107,
122
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
130,
134
]
} |
a 93-kda tyrosine protein kinase ( p93 ) identified previously as the gene product of the c-fes proto-oncogene , is highly expressed in hl-60 leukemia cells induced to differentiate to the granulocyte or monocyte phenotype . | NA | {
"id": "C0033681",
"name": "tyrosine protein kinase",
"pos": [
9,
32
]
} | {
"id": "C0072463",
"name": "product",
"pos": [
75,
82
]
} |
in contrast , in the presence of added gtp or gtp gamma s , two affinity states were again apparent for dslet competition at the delta receptor . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
39,
42
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
46,
57
]
} |
two mu receptor affinity states were again observed in the presence of added gtp or gtp gamma s . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
77,
80
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
84,
95
]
} |
sulmazole , ud-cg 212 cl , enoximone , piroximone , amrinone , and milrinone are all shown to be competitive antagonists of inhibitory a1 adenosine receptors , with ec50 values of 11-909 microm . | NA | {
"id": "C0002697",
"name": "amrinone",
"pos": [
52,
60
]
} | {
"id": "C0128513",
"name": "milrinone",
"pos": [
67,
76
]
} |
these include quinolines ( chloroquine , quinine , chinchonidine , and primaquine ) , acridines ( acridine , acridine orange , and quinacrine ) , and indole alkaloids ( yohimbine , corynanthine , reserpine , physostigmine , and the vindoline and catharanthine moieties of the vinca alkaloids ) , as well as other alkaloids and amines ( chlorpromazine , propranolol , atropine , and tryptamine ) . | NA | {
"id": "C0949738",
"name": "indole alkaloids",
"pos": [
150,
166
]
} | {
"id": "C0031849",
"name": "physostigmine",
"pos": [
208,
221
]
} |
these include quinolines ( chloroquine , quinine , chinchonidine , and primaquine ) , acridines ( acridine , acridine orange , and quinacrine ) , and indole alkaloids ( yohimbine , corynanthine , reserpine , physostigmine , and the vindoline and catharanthine moieties of the vinca alkaloids ) , as well as other alkaloids and amines ( chlorpromazine , propranolol , atropine , and tryptamine ) . | NA | {
"id": "C0949738",
"name": "indole alkaloids",
"pos": [
150,
166
]
} | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
313,
322
]
} |
this suggests a simple model for the control of dna replication in the cell cycle , whereby an essential replication factor is unable to cross the nuclear envelope but can only gain access to dna when the nuclear envelope breaks down at mitosis . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
14,
15
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
192,
195
]
} |
immunoglobulin a is the primary immunoglobulin isotype in tears , saliva , breast milk and other mucosal secretions , constituting between 6 % and 15 % of the total serum immunoglobulins . | NA | {
"id": "C0020835",
"name": "immunoglobulin a",
"pos": [
0,
16
]
} | {
"id": "C0021017",
"name": "immunoglobulin isotype",
"pos": [
32,
54
]
} |
we conclude that maximal transcription requires rotationally unique contacts between proteins bound to the two heat shock elements and also requires correct alignment of additional sites of dna-protein binding downstream of the proximal element . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
85,
93
]
} | {
"id": "C0012940",
"name": "dna-protein binding",
"pos": [
190,
209
]
} |
five of 15 methotrexate-treated patients and all five managed by observation alone demonstrated progesterone and 17-hydroxyprogesterone values below 1.0 ng/ml both initially and throughout the surveillance period , leading to resolution , indicating previous death of the corpus luteum . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
96,
108
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
113,
135
]
} |
seventy-four men of infertile couples , for whom a female infertility factor had been excluded , were followed for up to three years after semen analyses that included the sperm penetration assay , an in vitro test of sperm function . | NA | {
"id": "C0021359",
"name": "infertile",
"pos": [
20,
29
]
} | {
"id": "C0021361",
"name": "female infertility",
"pos": [
51,
69
]
} |
postpartum weight change : how much of the weight gained in pregnancy will be lost after delivery ? | NA | {
"id": "C0005911",
"name": "weight change",
"pos": [
11,
24
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
43,
49
]
} |
after adjustment for the effects of other variables on weight change , weight gains in pregnancy of 20 lb ( 9.1 kg ) or more were statistically significant ( p less than .05 ) ; | NA | {
"id": "C0005911",
"name": "weight",
"pos": [
55,
61
]
} | {
"id": "C0043094",
"name": "weight gains",
"pos": [
71,
83
]
} |
diethylpyrocarbonate and permanganate provide evidence for an unusual dna conformation induced by binding of the antitumour antibiotics bleomycin and phleomycin . | NA | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
136,
145
]
} | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
150,
160
]
} |
nuclear factor i ( nfi ) is a site-specific dna binding protein required for the replication of adenovirus dna in vitro and in vivo . | NA | {
"id": "C0069116",
"name": "nuclear factor i",
"pos": [
0,
16
]
} | {
"id": "C0012940",
"name": "dna binding protein",
"pos": [
44,
63
]
} |
the sparse fur with abnormal skin and hair ( spf-ash ) mouse is a model for the human x-linked hereditary disorder , ornithine transcarbamylase ( otc ) deficiency . | NA | {
"id": "C1138434",
"name": "x-linked hereditary disorder",
"pos": [
86,
114
]
} | {
"id": "C0268542",
"name": "ornithine transcarbamylase",
"pos": [
117,
143
]
} |
as more types of human immunodeficiency virus ( hiv ) are recognized and as the incidence of acquired immunodeficiency syndrome ( aids ) increases , more and more manifestations of hiv infection will be recognized . | NA | {
"id": "C0001175",
"name": "acquired immunodeficiency syndrome",
"pos": [
93,
127
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
181,
194
]
} |
clorazepate , a prodrug of the main metabolite of diazepam , desmethyldiazepam , regards further interest for anticonvulsant therapy because of a relatively slow onset of tolerance . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
50,
58
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
61,
78
]
} |
this enhancer lies between the adult beta-globin gene and the embryonic epsilon-globin gene , about equidistant from the two promoters . | NA | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
37,
48
]
} | {
"id": "C0014642",
"name": "epsilon-globin",
"pos": [
72,
86
]
} |
we show that the enhancer is able to stimulate expression from the epsilon-globin promoter as well as the beta-globin promoter . | NA | {
"id": "C0014642",
"name": "epsilon-globin",
"pos": [
67,
81
]
} | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
106,
117
]
} |
the phosphotyrosine content of the 115- to 120-kda proteins was greatly reduced in chicken embryo fibroblasts infected with mutants of rsv ( ny314 and sd10 ) encoding nonmyristoylated forms of the viral src gene product that do not associate with cellular membranes . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
51,
59
]
} | {
"id": "C0042736",
"name": "viral",
"pos": [
197,
202
]
} |
these similarities extend to other vertebrate integrin beta subunits , and we conclude that the myospheroid protein is an integrin beta subunit of drosophila . | NA | {
"id": "C1136316",
"name": "integrin beta subunits",
"pos": [
46,
68
]
} | {
"id": "C0021701",
"name": "integrin",
"pos": [
122,
130
]
} |
this contrasts with 21s rrna-encoding dna ( rdna ) intron conversion where the recipient , but not the donor dna , is cleaved at the element insertion site . | NA | {
"id": "C0012933",
"name": "rdna",
"pos": [
44,
48
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
109,
112
]
} |
beef insulin differs from pork insulin by only two amino acids in the a-chain loop , yet strain c57bl/10 ( b10 ) mice produce insulin-specific antibodies after immunization with beef insulin and fail to produce antibody after stimulation with pork insulin . | NA | {
"id": "C0021644",
"name": "insulin",
"pos": [
5,
12
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
211,
219
]
} |
we found that imprinting is associated with a 59 % increase in n-methyl-d-aspartate-sensitive binding of the excitatory amino acid l- [ 3h ] glutamic acid in the left imhv . | NA | {
"id": "C0243046",
"name": "excitatory",
"pos": [
109,
119
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
141,
154
]
} |
primary cultures of rabbit endometrial cells were used here to examine the effects of the tumor-promoting , diacylglycerol mimicking , phorbol ester , 12-o-tetradecanoyl phorbol-13-acetate ( tpa ) , on the prostaglandin control of cell proliferation . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
135,
148
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl",
"pos": [
151,
169
]
} |
it is apparent now that inhibin , which itself consists of a dimer of two different subunits , alpha and beta , is a member of a much larger family of ( glyco ) protein hormones and growth factors , which also includes mullerian-inhibiting substance , transforming growth factor-beta , erythroid differentiation factor , an insect protein that plays an important role in differentiation , and the dimer of two inhibin beta-subunits , activin . | NA | {
"id": "C0106025",
"name": "inhibin beta-subunits",
"pos": [
410,
431
]
} | {
"id": "C0050668",
"name": "activin",
"pos": [
434,
441
]
} |
high doses of thip temporarily abolished dyskinesias but also caused bradykinesia , ataxia , dystonia and myoclonic jerks . | NA | {
"id": "C0013384",
"name": "dyskinesias",
"pos": [
41,
52
]
} | {
"id": "C0004134",
"name": "ataxia",
"pos": [
84,
90
]
} |
high doses of thip temporarily abolished dyskinesias but also caused bradykinesia , ataxia , dystonia and myoclonic jerks . | NA | {
"id": "C0013384",
"name": "dyskinesias",
"pos": [
41,
52
]
} | {
"id": "C0027066",
"name": "myoclonic jerks",
"pos": [
106,
121
]
} |
a single 20 mg/kg dose of flz.hcl was administered to mice , with plasma and brain concentrations of flz and metabolites determined during 5 h after dosage . | NA | {
"id": "C0242293",
"name": "flz.hcl",
"pos": [
26,
33
]
} | {
"id": "C0016375",
"name": "flz",
"pos": [
101,
104
]
} |
although the bronchioloalveolar carcinomas were correctly ranked in the two highest probability categories 75 % of the time ( in 45 of 60 cases ) , there was considerable overlap with other lung lesions , particularly with adenocarcinoma and large cell undifferentiated carcinoma . | NA | {
"id": "C0007120",
"name": "bronchioloalveolar carcinomas",
"pos": [
13,
42
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
223,
237
]
} |
fisher 344 rats injected with a total of 20.8 +/- 1.5 mg of gold ( au ) as aurothioglucose over an 8-wk period were used to study the effect of long-term au treatment on selenium-dependent glutathione peroxidase ( segshpx ) , other enzymes related to gsh metabolism , gsh , nonprotein sulfhydryls , and total sulfhydryls ( sh ) in various tissues . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
60,
64
]
} | {
"id": "C0018033",
"name": "aurothioglucose",
"pos": [
75,
90
]
} |
new findings were ( i ) decreased platelet segshpx and kidney gssg reductase in aurothioglucose-injected rats , ( ii ) direct in vivo inhibition of kidney and liver segshpx in aurothioglucose-injected rats , and ( iii ) no significant correlation between the activity of gsh-metabolizing enzymes and levels of tissue gsh . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
62,
66
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
317,
320
]
} |
50 % inhibition occurred at the drug concentrations 5.10 ( -5 ) m for ( na+ , k+ ) -atpase and at 10 ( -4 ) m for mg++-atpase , respectively . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
72,
74
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
119,
125
]
} |
these results indicate that the inhibitory effect of perhexiline maleate on ( na+ , k+ ) -atpase and mg++-atpase may be a common feature shared by the lysosomotropic drugs . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
78,
80
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
106,
112
]
} |
the incorporation of tritiated proline into gmb proline was regarded as a measure of total protein synthesis and the incorporation into hydroxyproline as indicative of collagen synthesis . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
31,
38
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
136,
150
]
} |
total gbm protein and collagen synthesis rates were calculated from the simultaneous measurements of specific activities in the precursor ( tissue-free ) and protein-bound ( gbm proline and hydroxyproline ) pools . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
178,
185
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
190,
204
]
} |
investigation of the associations of a number of hla antigens with psoriasis and psoriatic arthritis . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
67,
76
]
} | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
81,
100
]
} |
a method , using the glim computer package , for determining primary and secondary hla associations with disease is described and is applied to data from patients with psoriasis and psoriatic arthritis . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
168,
177
]
} | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
182,
201
]
} |
in a group of 11 rats , wheatgerm agglutinin conjugated to horseradish peroxidase ( wga : hrp ) was injected either in the first somatosensory area of cortex ( si ) or in the dorsal column nuclei ( dcn ) . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
59,
81
]
} | {
"id": "C0078473",
"name": "wga : hrp",
"pos": [
84,
93
]
} |
its 3 ' ss domain selects a complementary site on the target ss dna , hybridizes with it to form the ds cleavage site , and serves as a primer to convert the ss m13mp7 target to ds dna . | NA | {
"id": "C0012935",
"name": "ss dna",
"pos": [
61,
67
]
} | {
"id": "C0012854",
"name": "ds dna",
"pos": [
178,
184
]
} |
mice with intraperitoneal infections of t. gondii that received no antibody survived and developed chronic t. gondii infection , whereas the infected mice that received the monoclonal antibody died of toxoplasmosis . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
67,
75
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
173,
192
]
} |
we assessed the complications associated with emergency department placement of subclavian vein catheters in trauma and burn patients , reviewing the charts of all of the 441 patients admitted to the burn-trauma unit through the emergency department during 1983 . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
109,
115
]
} | {
"id": "C0006434",
"name": "burn-trauma",
"pos": [
200,
211
]
} |
liver transplantation , which is increasingly indicated for patients with end-stage liver disease and variceal bleeding , is dictated by the degree of hepatic failure . | NA | {
"id": "C0745744",
"name": "end-stage liver disease",
"pos": [
74,
97
]
} | {
"id": "C0085605",
"name": "hepatic failure",
"pos": [
151,
166
]
} |
blood was taken up to 1 week after the diazepam injections for assay of diazepam and desmethyldiazepam . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
39,
47
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
85,
102
]
} |
we focus on problems of case-definition , differences between 'african ' and 'western ' aids and the implications for south africa , and problems with sensitivity and specificity of tests used at present , particularly in the context of false positivity in a community with a low prevalence of hiv infection . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
88,
92
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
294,
307
]
} |
with the exception of penicillin , ampicillin , amoxicillin , and cephradine , the isolates were uniformly sensitive to all the other antibiotics tested ( including spectinomycin , tetracycline , rosoxacin , sulfamethoxazole-trimethoprim [ 19:1 ratio ] , and kanamycin ) . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
35,
45
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
48,
59
]
} |
penicillin and cefaclor showed this effect only with ppng strains , whereas for ampicillin and amoxicillin it was also seen with non-ppng strains . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
80,
90
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
95,
106
]
} |
pb pretreatment consisted of an ip injection of sodium pb ( 80 mg/kg ) in saline ( 0.9 % ) for 2 successive days . | NA | {
"id": "C0031412",
"name": "pb",
"pos": [
0,
2
]
} | {
"id": "C0282303",
"name": "sodium pb",
"pos": [
48,
57
]
} |
if classic symptoms and signs are being absent , evidence of an infection should suggest meningitis , if other common infections , like urinary tract or respiratory infections , are excluded , and even in these cases a concomitant meningitis may be possible . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
64,
73
]
} | {
"id": "C0035243",
"name": "respiratory infections",
"pos": [
153,
175
]
} |
33p-labeled proteins were obtained by phosphorylation of nhp fractions in the presence of [ gamma-33p ] atp . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
12,
20
]
} | {
"id": "C0028589",
"name": "nhp",
"pos": [
57,
60
]
} |
the frequency of subsequent tumor development in patients suffering from acquired ichthyosis and darier 's erythema as well as cases of concurrent dermatosis and malignant diseases was studied . | NA | {
"id": "C0041834",
"name": "erythema",
"pos": [
107,
115
]
} | {
"id": "C0037274",
"name": "dermatosis",
"pos": [
147,
157
]
} |
as a result , cases of acquired ichthyosis should be considered at high risk for cancer for life while patients with darier 's erythema aged more than 40 years should not be necessarily tested for tumors unless they have suffered dermatosis for at least three years . | NA | {
"id": "C0041834",
"name": "erythema",
"pos": [
127,
135
]
} | {
"id": "C0037274",
"name": "dermatosis",
"pos": [
230,
240
]
} |
yet , apart from these findings , no correlations were found to exist between reflux incidence and tumour localisation nor between histological tumour type and tumour size . | NA | {
"id": "C0027651",
"name": "tumour",
"pos": [
99,
105
]
} | {
"id": "C0027652",
"name": "histological tumour type",
"pos": [
131,
155
]
} |
ninety-eight brain contusions in 17 patients served as a data base for a comparative study of mr and ct for defining brain contusions . | NA | {
"id": "C0149844",
"name": "brain contusions",
"pos": [
13,
29
]
} | {
"id": "C0009938",
"name": "contusions",
"pos": [
123,
133
]
} |
in a retrospective analysis , patients with chronic stable angina were compared on the basis of presence or absence of angina during ischemia detected by thallium imaging . | NA | {
"id": "C0340288",
"name": "chronic stable angina",
"pos": [
44,
65
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
119,
125
]
} |
basal cell carcinoma ( bcc ) was seen in 61 % , squamous cell carcinoma ( scc ) in 26 % , and 13 % of patients had tumors with bcc and scc features . | NA | {
"id": "C0007117",
"name": "basal cell carcinoma",
"pos": [
0,
20
]
} | {
"id": "C0007097",
"name": "bcc",
"pos": [
127,
130
]
} |
the results of flow cytometry were compared with the tritiated thymidine labeling index ( tli ) in 314 tumors studied in one laboratory and 163 tumors from a second laboratory , a total of 477 , including 306 breast carcinomas . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
103,
109
]
} | {
"id": "C0085183",
"name": "tumors",
"pos": [
144,
150
]
} |
since histamine has recently been shown to play an important role in the pathogenesis of atherosclerosis in experimental nonketotic diabetes , and since leukocytes and platelets contain most of the histamine in blood , we have determined the levels of histamine in these cells from patients with peripheral vascular disease ( pvd ) , insulin-dependent diabetes mellitus ( iddm ) and non-insulin-dependent diabetes mellitus ( niddm ) . | NA | {
"id": "C0011853",
"name": "experimental",
"pos": [
108,
120
]
} | {
"id": "C0011849",
"name": "non-insulin-dependent diabetes mellitus",
"pos": [
383,
422
]
} |
three of nine anaplastic astrocytomas and one of ten glioblastomas had an identifiable aneuploid peak , while all four well differentiated astrocytomas were diploid . | NA | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
53,
66
]
} | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
139,
151
]
} |
the dramatic decline in pinworm identification and the fall in the number of specimens sent by practitioners at this medical center , and reported elsewhere in the united states by other investigators , may reflect a genuine decline in oxyuriasis occurring in the patient populations served . | NA | {
"id": "C0086227",
"name": "pinworm",
"pos": [
24,
31
]
} | {
"id": "C0030100",
"name": "oxyuriasis",
"pos": [
236,
246
]
} |
no sex differences were found in the strength of the association between anthropometric variables and osteoarthritis , nor was there evidence to suggest that obesity is a consequence of knee osteoarthritis rather than a risk factor . | NA | {
"id": "C0029408",
"name": "osteoarthritis",
"pos": [
102,
116
]
} | {
"id": "C0409959",
"name": "of knee",
"pos": [
183,
190
]
} |
the fragile site at xq27 ( fraxa ) is associated with a common form of x-linked mental retardation ( martin-bell syndrome ) . | NA | {
"id": "C1136249",
"name": "x-linked",
"pos": [
71,
79
]
} | {
"id": "C0016667",
"name": "martin-bell syndrome",
"pos": [
101,
121
]
} |
the combination of denaturing gradient gel electrophoresis ( dgge ) and in vitro dna amplification has allowed us to ( 1 ) localize a dna mutation to a given 100-bp region of the human genome and ( 2 ) rapidly sequence the dna without cloning . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
132,
137
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
223,
226
]
} |
ki67 monoclonal antibody was used by combined immunohistochemical methods together with antibodies recognizing macrophage- and t-cell-subset-related antigens using avidin-biotin peroxidase ( abc ) and alkaline phosphatase-anti-alkaline phosphatase ( apaap ) systems . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
5,
15
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
88,
98
]
} |
positivity was generally restricted to normal neuronal structures and neuronal tumors , including adrenal neuroblastoma , ganglioneuroblastoma , olfactory neuroblastoma , pheochromocytoma , carotid body paraganglioma , duodenal gangliocytic paraganglioma , and teratoma with neuroepithelial components . | NA | {
"id": "C0031511",
"name": "pheochromocytoma",
"pos": [
171,
187
]
} | {
"id": "C0030421",
"name": "gangliocytic paraganglioma",
"pos": [
228,
254
]
} |
stainable bone iron may thus be a useful criterion for early detection of hemochromatosis and other types of potentially toxic iron overload . | NA | {
"id": "C0018995",
"name": "hemochromatosis",
"pos": [
74,
89
]
} | {
"id": "C0282193",
"name": "iron overload",
"pos": [
127,
140
]
} |
further , since cortisol influences epinephrine formation in the adrenal medulla and since cortisol and epinephrine contribute to beta receptor function , it is further postulated that an increase in brain ne by depressing the hpa axis could thereby , cause a relative decrease in both cortisol and epinephrine with resultant beta receptor dysfunction . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
39,
41
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
299,
310
]
} |
before treatments , magnitudes of bacteriuria were similar in all experimental groups , and uti persisted in all nontreated dogs . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
34,
45
]
} | {
"id": "C0042029",
"name": "uti",
"pos": [
92,
95
]
} |
the interactions between invasive malignant cells and normal fibroblastic cells were studied in a cellular spheroid model in vitro . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
54,
60
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
61,
73
]
} |
the mod cells also incorporated a slightly higher percentage of 75se-selenite into proteins and attained a higher ratio of selenoprotein to selenonucleic acids than did comma-d cells . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
83,
91
]
} | {
"id": "C0074302",
"name": "selenoprotein",
"pos": [
123,
136
]
} |
in addition , relapse following growth of hormone - insensitive cells , and the present observations of further evidence of immunosuppression demonstrated by the significant ( p less than 0.001 ) effect of des on the lytic activity of natural killer cells vs. the negligible effect of the luteinizing - hormone - releasing - hormone , leuprolide ( lupron ) raises concern that the palliative effects of oestrogen therapy are possibly further compromised by a reduction in immunosurveillance to tumour , or equally important , by a decreased capacity to cope with infectious agents . | NA | {
"id": "C0023610",
"name": "luteinizing",
"pos": [
289,
300
]
} | {
"id": "C0085272",
"name": "leuprolide",
"pos": [
335,
345
]
} |
continuing controversy surrounding the dominican republic studies of 5-alpha-reductase deficiency and the development of gender identity in male pseudohermaphrodites concerns the roles of culture and biology in determining the ambiguity of gender socialization in an unsophisticated population . | NA | {
"id": "C0086582",
"name": "male",
"pos": [
140,
144
]
} | {
"id": "C0079399",
"name": "gender",
"pos": [
240,
246
]
} |
differences in etiology and different particulars of the pathologic conditions imply that gab is a nonspecific reaction , not a unique disease . | NA | {
"id": "C0030660",
"name": "pathologic conditions",
"pos": [
57,
78
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
135,
142
]
} |
in a one-year , double-masked , randomized study , the ocular hypotensive efficacy of twice-daily treatment with 0.25 % levobunolol hydrochloride or timolol maleate was evaluated in 78 patients with glaucoma or ocular hypertension ( phase 1 ) . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
199,
207
]
} | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
211,
230
]
} |
we used liquid scintillation spectrometry to quantitate the tritiated thymidine incorporation into cells in the vitreous , retina , and optic nerve head following intravitreal injection of 250,000 homologous dermal fibroblasts . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
56,
59
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
215,
226
]
} |
although both pldlr-cat 234 and pldlr-cat 6500 contain sequences related to the recently reported consensus sequence for cyclic amp responsiveness , treatment of the transfected jeg-3 cells with 8-bromo-camp did not increase cat activity . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
121,
131
]
} | {
"id": "C0000661",
"name": "8-bromo-camp",
"pos": [
195,
207
]
} |
the effect of lipid a , a residue of the lipopolysaccharide molecule , on protein kinase c from b lymphocytes has been studied . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
14,
21
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
41,
59
]
} |
a significant decline in amount of active elongation factor , ef-1 alpha , and in its catalytic activity was observed in cell-free extracts prepared from normal human diploid fibroblasts ( mrc-5 ) and their sv40-transformed counterparts , after subjecting the cells to 60 min heat shock at different temperatures . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
175,
186
]
} | {
"id": "C0007634",
"name": "the cells",
"pos": [
256,
265
]
} |
we demonstrate , however , that two calcitonin analogs , [ gly8 , ala16 ] -des-leu19 salmon calcitonin and des-1-amino- [ ala1,7 , gly8 ] -des-leu19 salmon calcitonin have minimal interactions with phospholipids . | NA | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
36,
46
]
} | {
"id": "C0073994",
"name": "salmon calcitonin",
"pos": [
149,
166
]
} |
monoclonal antibodies were prepared against the 27-34k insulin-like growth factor ( igf ) -binding protein purified from human placenta/decidua and designated placental protein 12 ( pp12 ) . | NA | {
"id": "C0074825",
"name": "insulin-like growth",
"pos": [
55,
74
]
} | {
"id": "C0123256",
"name": "placental protein 12",
"pos": [
159,
179
]
} |
in liquid phase ria , igf-i did not affect the binding of [ 125i ] pp12 to one antibody ( mab 6303 ) , it slightly increased the binding to two antibodies ( mab 6301 and 6304 ) , and it slightly decreased the binding to one antibody ( mab 6302 ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
79,
87
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
235,
238
]
} |
all antibodies immunoprecipitated the cross-linked pp12- [ 125i ] igf-i complex , but mab 6302 considerably less effectively than the others . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
86,
89
]
} |
these results suggest that mab 6302 binds to an epitope at or near to the igf-binding site , whereas the other antibodies react at other sites of the pp12 molecule . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
27,
30
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
111,
121
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.