text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the finding of keratin subtypes closely associated with the development of keratinizing epithelium ( the 68 kda basic keratin ) in sclc was unexpected in a tumor that is regarded as poorly differentiated . | NA | {
"id": "C0010803",
"name": "keratin",
"pos": [
15,
22
]
} | {
"id": "C1179973",
"name": "basic",
"pos": [
112,
117
]
} |
the cellular pharmacology of doxorubicin resistance ( doxr ) has most commonly been associated with decreased drug uptake , enhanced drug efflux , cross-resistance to multiple anticancer agents , and the overproduction of a mr 170,000 cell surface glycoprotein ( termed p-glycoprotein ) . | NA | {
"id": "C0025248",
"name": "cell surface glycoprotein",
"pos": [
235,
260
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
272,
284
]
} |
a wka rat fetus-derived fibroblast cell line wfb showed strict nontransformant phenotypes in vitro such as anchorage dependency of cell growth in soft agar , contact inhibition , and serum dependency on the monolayer cell culture . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
24,
34
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
217,
221
]
} |
the cm was also active on other human cancer cells as a growth inhibitor , but not on normal human fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
45,
50
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
99,
110
]
} |
by the fourth passage after treatment , both carcinogens induced increased survival , colony formation in agar-methocel , multinucleation , and increased reactivity with the tumor associated antigen b1:1 , an epitope of carcinoembryonic antigen , and the lectins concanavalin a , dolichos biflorus , and soybean agglutinin . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
191,
198
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
209,
216
]
} |
to evaluate a possible direct cytotoxic effect of diethylstilbestrol diphosphate ( desdp ) in the treatment of prostate cancer we exposed three prostatic carcinoma cell lines ( lncap , du 145 , and pc-3 ) , 2 nonprostatic neoplastic cell lines ( kb and ej ) , and one nontransformed cell line ( mrc-5 ) to diethylstilbestrol ( des ) , diethylstilbestrol monophosphate , and desdp at levels occurring in patients ' sera during p.o . | NA | {
"id": "C0012203",
"name": "diethylstilbestrol",
"pos": [
50,
68
]
} | {
"id": "C0060692",
"name": "levels",
"pos": [
383,
389
]
} |
a tumor-related mortality of 100 % was noted when the six different human lung tumor cell lines , including a549 adenocarcinoma , nci-h125 adenosquamous carcinoma , nci-h460 large cell undifferentiated carcinoma , nci-h69 small cell carcinoma , and nci-h358 and nci-h322 bronchioloalveolar cell carcinomas , were implanted i.b . at a 1.0 x 10 ( 6 ) tumor cell inoculum . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
113,
127
]
} | {
"id": "C0007120",
"name": "bronchioloalveolar cell",
"pos": [
271,
294
]
} |
the structure of the capsular polysaccharide elaborated by streptococcus pneumoniae type 18f ( s18f ) has been investigated by using n.m.r . spectroscopy , methylation analysis , and characterisation of oligosaccharides obtained on partial hydrolysis . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
30,
44
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
203,
219
]
} |
a sandwich enzyme immunoassay was developed to detect circulating immune complexes containing carcinoembryonic antigen ( cea ) and immunoglobulin ( ig ) g , iga , or igm using a nitrocellulose-bound anti-cea antibody as the solid phase reagent . | NA | {
"id": "C0003313",
"name": "circulating immune",
"pos": [
54,
72
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
208,
216
]
} |
the effect of the shift from a low to a high luminosity of the environment on the urinary excretion of norepinephrine ( ne ) and epinephrine ( e ) was studied in migraineurs ( 26 cases ) and controls ( 25 cases ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
103,
117
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
129,
140
]
} |
by denaturation , size fractionation , and renaturation , however , nf-kappa b activity can be revealed in cytosolic fractions , showing that the dna-binding protein is present but inhibited in its binding activity . | NA | {
"id": "C0079904",
"name": "nf-kappa b",
"pos": [
68,
78
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
146,
165
]
} |
donor animals sensitized systemically ( via footpad ) or locally in gut mucosa ( via peyer 's patches ) to syngeneic or xenogeneic epithelial antigens generated specific immunoglobulin and were found to have t lymphocytes in the draining nodal areas ( including the mesenteric nodes ) which were ( a ) antigen-specific , having a [ 3h ] thymidine uptake in the presence of antigen 30-fold the control ; | NA | {
"id": "C0003333",
"name": "xenogeneic",
"pos": [
120,
130
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
373,
380
]
} |
specificity for complement receptor function was confirmed by the ability of anti-cr1 antibody to block adherence of lif-treated pmn to eac3b ( 77.0 % inhibition ) and anti-cr3 antibody to block adherence to eac3bi ( 70.2 % inhibition ) . | NA | {
"id": "C0034793",
"name": "complement",
"pos": [
16,
26
]
} | {
"id": "C0079785",
"name": "cr3",
"pos": [
173,
176
]
} |
cd3+ wt31- t cells were sorted from peripheral blood of a normal healthy donor by a facs iv and cloned by limiting dilution in the presence of a phorbol ester ( tetradecanoyl phorbol acetate , tpa ) , calcium ionophore ( ionomycin , io ) , interleukin-2 ( il-2 ) , allogeneic cells , and phytohemagglutinin ( pha ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
145,
158
]
} | {
"id": "C0039654",
"name": "tetradecanoyl phorbol acetate",
"pos": [
161,
190
]
} |
in contrast , the in vitro activation of the uveitogenic potential of ths cells , incubated with antigen in the presence of csa or csg and adoptively transferred into untreated recipients , was not affected by the cyclosporins . | NA | {
"id": "C0010592",
"name": "csa",
"pos": [
124,
127
]
} | {
"id": "C0010594",
"name": "cyclosporins",
"pos": [
214,
226
]
} |
antigen-presenting cells ( apc ) could be briefly pulsed with alpha-msh and then present the alpha-msh antigenic determinant to t cells , indicating that the relevant antigen was retained by the apc . | NA | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
103,
124
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
167,
174
]
} |
this antiserum recognizes a cross-reactive idiotype ( cri ) present on 20-25 % of anti-cii antibodies from dba/1 mice immunized with bovine cii . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
5,
14
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
91,
101
]
} |
ca2+-atpase of the sarcoplasmic reticulum was localized in cryostat sections from three different adult canine skeletal muscles ( gracilis , extensor carpi radialis , and superficial digitalis flexor ) by immunofluorescence labeling with monoclonal antibodies to the ca2+-atpase . | NA | {
"id": "C0916181",
"name": "ca2",
"pos": [
0,
3
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
267,
270
]
} |
type i ( slow ) myofibers were strongly labeled for the ca2+-atpase with a monoclonal antibody ( ii d8 ) to the ca2+-atpase of canine cardiac sarcoplasmic reticulum ; | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
56,
59
]
} | {
"id": "C0916181",
"name": "ca2",
"pos": [
112,
115
]
} |
these latter consisted of a spacer peptide and a mature mating factor and there were three units in s. uvarum and five units in s. italicus compared with four units in the mf alpha 1 of s. cerevisiae . | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
35,
42
]
} | {
"id": "C0065743",
"name": "mating factor",
"pos": [
56,
69
]
} |
the transforming trp-1 gene integrated at or near the resident site in all of the trp-1+ transformants obtained with circular dna or dna cut within the trp-1 coding region . | NA | {
"id": "C0012925",
"name": "circular",
"pos": [
117,
125
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
133,
136
]
} |
subsequently , we showed that under these conditions fura exhibited a time-dependent removal from dna accompanied by a decrease in dna strand length . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
27,
28
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
131,
134
]
} |
a specific , sensitive and reliable hplc method for the determination of doxorubicin ( dx ) , epirubicin ( epidx ) and their known fluorescent metabolites [ doxorubicinol ( dxol ) , epirubicinol ( epidxol ) 7-deoxy-adriamycinone ( metabolite c ) , adriamycinone ( metabolite d ) , 7-deoxy-13-dihydro-adriamycinone ( metabolite e ) , 13-dihydro-adriamycinone ( metabolite f ) , 4'-o-beta-d-glucuronyl-4'-epidx ( metabolite g ) and 4'-o-beta-d-glucuronly 13-dihydro-4'-epidx ( metabolite h ) ] in biological fluids ( human plasma , bile and urine ) has been developed and tested . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
73,
84
]
} | {
"id": "C0014582",
"name": "epirubicin",
"pos": [
182,
192
]
} |
in vitro antiproliferative activity of 2'- ( 2-hydroxyphenyl ) -2'-thiazoline-4'-carboxylic acid and its methyl ester on l1210 and p388 murine neoplasms . | NA | {
"id": "C0007066",
"name": "carboxylic acid",
"pos": [
81,
96
]
} | {
"id": "C0014898",
"name": "ester",
"pos": [
112,
117
]
} |
in contrast , low-titer antibodies of a single , mostly igm , class were found in certain patients without evidence of autoimmune disease or with non-sle autoimmune diseases . | NA | {
"id": "C0024141",
"name": "sle",
"pos": [
150,
153
]
} | {
"id": "C0004364",
"name": "autoimmune",
"pos": [
154,
164
]
} |
human peripheral blood mononuclear cells when cultured for the short term ( 11 days ) produce an optimal igm plaque-forming cell ( pfc ) response to sheep erythrocytes , which is dependent on macrophages and t suppressor and helper lymphocytes . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
6,
40
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
124,
128
]
} |
ic-7 and ic-9 fractions and microfilariae excretory-secretory ( mf es ) antigen share common antigenic determinants as revealed by the fact that saturation of immobilized antibodies with ic-7 or ic-9 inhibited the binding of mf es antigen coupled to penicillinase . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
72,
79
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
93,
115
]
} |
when added to the bath , the active phorbol ester , 12-o-tetradecanoyl phorbol-13-acetate ( 100 nm ) increased the slowly inactivating ( l-type ) current by 32 +/- 20 % ( n = 8 , +/- sd ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
36,
49
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl phorbol-13-acetate",
"pos": [
52,
89
]
} |
although this species lacks an inotropic response to angiotensin peptides , there is a dose-dependent increase in inositol-1-phosphate production in response to angiotensin ii , and this response is blocked by the selective angiotensin ii antagonist [ sar1 , ile8 ] angiotensin ii . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
53,
64
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
266,
280
]
} |
to test this hypothesis , we studied a group of patients , each with a representative tachycardia ( ventricular tachycardia , circus-movement tachycardia involving an atrioventricular bypass pathway , atrial tachycardia , and atrial flutter ) . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
100,
123
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
208,
219
]
} |
the intensity of porphyrin fluorescence also depends on ionic strength , reaching sharp maxima at 0.1 mol/l ( for uroporphyrin ) and 1 mol/l ( for coproporphyrin ) . | NA | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
17,
26
]
} | {
"id": "C0042093",
"name": "uroporphyrin",
"pos": [
114,
126
]
} |
the intensity of porphyrin fluorescence also depends on ionic strength , reaching sharp maxima at 0.1 mol/l ( for uroporphyrin ) and 1 mol/l ( for coproporphyrin ) . | NA | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
17,
26
]
} | {
"id": "C0009988",
"name": "coproporphyrin",
"pos": [
147,
161
]
} |
however , when urine samples from healthy persons were electrophoresed in the absence of sds using polyacrylamide gel or agarose gel , or a cellulose acetate membrane , albumin but not uromucoid , frequently formed the main protein band . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
169,
176
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
224,
231
]
} |
because of the presence of close parental consanguinity , we believe this constellation of findings represents a new syndrome , possibly transmitted as an autosomal recessive disorder . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
117,
125
]
} | {
"id": "C0012634",
"name": "disorder",
"pos": [
175,
183
]
} |
forty-two adult males -- 10 with klinefelter 's syndrome ( karyotype xxy ) , 17 with normal sex chromosome karyotype ( xy ) but with physical signs of hypogonadism , and 15 presumed to be normal both chromosomally and hormonally -- completed tests of verbal and nonverbal ability . | NA | {
"id": "C0022735",
"name": "klinefelter 's syndrome",
"pos": [
33,
56
]
} | {
"id": "C0020619",
"name": "hypogonadism",
"pos": [
151,
163
]
} |
when blood pressure was correlated with the urinary catecholamines , however , a significant correlation with epinephrine ( r = 0.45 ; p less than 0.05 ) and with norepinephrine ( r = 0.44 ; p less than 0.05 ) was found . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
110,
121
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
163,
177
]
} |
the number of free sulfhydryl ( sh ) groups of both human alpha-fetoprotein ( afp ) and albumin , isolated simultaneously from human cord serum , was determined by reacting the proteins with 5,5'-dithiobis ( 2-nitrobenzoic acid ) ( dtnb ) . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
88,
95
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
177,
185
]
} |
when both proteins were pretreated with 100 mmol/l 2-mercaptoethanol , only approximately 0.5 sh groups were detected per molecule of human adult albumin , yet as many as 4 per molecule were found with afp . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
10,
18
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
146,
153
]
} |
we have also identified by radioimmunoprecipitation assays intravenous drugs abusers who have antibody solely to the nuclear px gene product and who do not , therefore , test positive in an elisa assay prepared from purified virion proteins . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
117,
124
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
232,
240
]
} |
burkitt 's lymphoma , which is associated with ebv infection , appears to result when ebv-driven lymphoproliferations undergo cytogenetic translocations involving predominantly chromosome 8 . | NA | {
"id": "C0006413",
"name": "burkitt 's lymphoma",
"pos": [
0,
19
]
} | {
"id": "C0149678",
"name": "ebv infection",
"pos": [
47,
60
]
} |
hemorrhagic shock was induced by bleeding into a heparinized reservoir to achieve ( t = 0 ) and maintain map at 45 mm hg . | NA | {
"id": "C0036982",
"name": "hemorrhagic shock",
"pos": [
0,
17
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
33,
41
]
} |
an attempt was made to isolate individual antibodies from the antiserum by selective elution from immunoblots of the components of the sgp-complex separated by sds-page . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
42,
52
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
62,
71
]
} |
vitamin a has been determined in tear fluid and blood plasma of marginally nourished thai children before and after supplementation with a single , oral dose of 110 mg retinyl palmitate . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
0,
9
]
} | {
"id": "C0073115",
"name": "retinyl palmitate",
"pos": [
168,
185
]
} |
these results may imply a role for the iga-containing fraction of tears from hsv-infected animals in preventing viral attachment to cells and suggest that antibody of this isotype plays a protective role at the ocular surface . | NA | {
"id": "C0020835",
"name": "a",
"pos": [
15,
16
]
} | {
"id": "C0021017",
"name": "antibody",
"pos": [
155,
163
]
} |
analyzing data from two large controlled clinical trials in patients with chronic liver disease : 1 ) the multicenter trial of prednisone versus placebo in cirrhosis conducted by the copenhagen study group for liver diseases ( csl-1 ) and 2 ) the multinational trial of azathioprine versus placebo in primary biliary cirrhosis ( pbc-1 ) we have developed indices for prediction of prognosis and therapeutic effect using cox 's multiple regression model for censored survival data . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
156,
165
]
} | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
210,
224
]
} |
the differential diagnosis of masses in the posterior mediastinum includes neurogenic neoplasms , cysts , esophageal tumors , infectious processes including abscesses , and disorders of the thoracic spine . | NA | {
"id": "C0027651",
"name": "neoplasms",
"pos": [
86,
95
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
98,
103
]
} |
to investigate the mechanisms contributing to refractoriness in exercise-induced asthma ( eia ) , airway responsiveness to histamine was studied in eight asthmatic patients . | NA | {
"id": "C0004099",
"name": "exercise-induced",
"pos": [
64,
80
]
} | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
154,
163
]
} |
the main cause of the fractures is increased bone fragility due to low bone density , although in the elderly an increase in the frequency of falls and in the trauma produced by the falls also contributes to fractures . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
159,
165
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
208,
217
]
} |
in 47 healthy blood donors ( controls ) and 29 renal allograft recipients ( patients ) the relative contents of rna and dna of peripheral blood mononuclear ( pbm ) cell populations were estimated from the intensities of green and red fluorescences emitted by complexes that form with dna and rna , respectively , after staining the cells with the metachromatic dye , acridine orange . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear",
"pos": [
127,
155
]
} | {
"id": "C0007634",
"name": "the cells",
"pos": [
328,
337
]
} |
pbm cell populations of controls contained less than 0.5 % proliferating ( sg2m ) cells with highly variable relative rna contents . | NA | {
"id": "C1321301",
"name": "pbm cell",
"pos": [
0,
8
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
82,
87
]
} |
unlike controls , pbm cell populations of patients contained significantly higher percentages of sg2m-cells which were significantly correlated with the relative coefficients of variation ( rcv ) of the f530 histograms of g0/1-cells ; | NA | {
"id": "C1321301",
"name": "pbm cell",
"pos": [
18,
26
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
227,
232
]
} |
each subject underwent six studies on separate days with intravenous infusion of saline , naloxone 40 micrograms/kg/hr , morphine sulfate 40 micrograms/kg/hr , morphine and naloxone combined , naloxone and atropine 13 micrograms/kg/hr , and morphine and bethanechol 16 micrograms/kg/hr . | NA | {
"id": "C0066814",
"name": "morphine sulfate",
"pos": [
121,
137
]
} | {
"id": "C0026549",
"name": "morphine",
"pos": [
241,
249
]
} |
a mixed pool of oligodeoxynucleotides is synthesized by contaminating the monomeric nucleotides with low levels of the other three nucleotides such that the full-length oligonucleotide contains on the average one to two changes per molecule . | NA | {
"id": "C0028948",
"name": "oligodeoxynucleotides",
"pos": [
16,
37
]
} | {
"id": "C0028953",
"name": "oligonucleotide",
"pos": [
169,
184
]
} |
the antigen is a natural immunogen , although it lacks repeating epitopes of many p. falciparum antigens . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
65,
73
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
96,
104
]
} |
after ingestion of metformin , a drug of the biguanide class , there are gastrointestinal effects in the form of nausea and vomiting , and about 30 % of the drug is recovered in feces . | NA | {
"id": "C0025598",
"name": "metformin",
"pos": [
19,
28
]
} | {
"id": "C0005382",
"name": "biguanide",
"pos": [
45,
54
]
} |
[ effectiveness of combined treatment with glibenclamide and insulin in secondary sulfonylurea failure . a controlled multicenter double-blind clinical trial ] . | NA | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
43,
56
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
82,
94
]
} |
the effectiveness of combined insulin and glibenclamide was compared with that of insulin alone in a multicenter double-blind trial of secondary sulphonylurea failures . | NA | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
42,
55
]
} | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
145,
158
]
} |
the results indicate that combined insulin/glibenclamide , given over a period of six months to patients with secondary sulphonylurea failure , provided metabolic results as good as those with insulin alone . | NA | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
43,
56
]
} | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
120,
133
]
} |
the membrane protein , cross-linked with [ 125i ] egf , had a mol wt of 170,000 , and this protein ( egf receptor ) was phosphorylated basally or by the addition of egf . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
4,
20
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
91,
98
]
} |
in this study we examine the capacity to esterify cholesterol ( acat ) and to hydrolyze cholesterol esters ( ceh ) in the lipid-rich and lipid-poor regions of the guinea pig adrenal in control animals and animals treated with acth or dexamethasone ( dex ) . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
50,
61
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
88,
106
]
} |
competition experiments showed that the relative order of potency of a variety of indoles for inhibition of 2- [ 125i ] iodomelatonin binding site to hamster brain membranes was as follows : 6-chloromelatonin greater than or equal to 2-iodomelatonin greater than n-acetylserotonin greater than or equal to 6-methoxymelatonin greater than or equal to melatonin greater than 6-hydroxymelatonin greater than or equal to 6,7-dichloro-2-methylmelatonin greater than 5-methoxytryptophol greater than 5-methoxytryptamine greater than or equal to 5-methoxy-n , n-dimethyltryptamine greater than n-acetyltryptamine greater than serotonin greater than 5-methoxyindole ( inactive ) . | NA | {
"id": "C0000589",
"name": "methoxytryptamine",
"pos": [
496,
513
]
} | {
"id": "C0036751",
"name": "serotonin",
"pos": [
619,
628
]
} |
in the mammalian pancreas , prosomatostatin is cleaved at the site of the single arginyl residue ( corresponding to position 6 in hagfish somatostatin-34 ) and at the arginine-lysine site ( corresponding to positions 19 and 20 in the hagfish peptide ) to generate somatostatin-14 and somatostatin-28 ( 1-12 ) -peptide . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
264,
279
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
284,
299
]
} |
amino acids l-canavanine and l-s-aminoethylcysteine , at concentrations as high as 5 mm , each inhibited steroidogenesis to a much greater extent than they inhibited protein synthesis . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
0,
11
]
} | {
"id": "C0006825",
"name": "canavanine",
"pos": [
14,
24
]
} |
however , no differences in da turnover between the two groups were apparent on day 60 , indicating a recovery of normal dopaminergic activity . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
28,
30
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
121,
133
]
} |
in contrast , the phorbol ester , tetradecanoyl phorbol acetate ( tpa ) stimulated iodide organification in slices and follicles but inhibited it in cells . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
18,
31
]
} | {
"id": "C0039654",
"name": "tetradecanoyl",
"pos": [
34,
47
]
} |
plasma epi , but not ne , was decreased to similar levels after treatment with peripheral or central pnmt inhibitors . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
7,
10
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
21,
23
]
} |
all three types of antisera recognize the sialylated beta ctp as equivalent to the whole hormone on a molar basis , indicating that this peptide region of the whole hormone is neither sequestered nor conformationally altered . | NA | {
"id": "C0019932",
"name": "hormone",
"pos": [
89,
96
]
} | {
"id": "C0597192",
"name": "peptide",
"pos": [
137,
144
]
} |
we have previously shown that human decidua , but not placenta , synthesizes and secretes a 34 k igf-binding protein ( 34 k igf-bp ) called placental protein 12 . | NA | {
"id": "C0074825",
"name": "igf-binding protein",
"pos": [
97,
116
]
} | {
"id": "C0123256",
"name": "placental protein 12",
"pos": [
140,
160
]
} |
we now used human choriocarcinoma jeg-3 cell monolayer cultures and recombinant ( thr59 ) igf-i as a model to study whether the decidual 34 k igf-bp is able to modulate the receptor binding and biological activity of igfs in trophoblasts . | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
90,
95
]
} | {
"id": "C0037657",
"name": "igfs",
"pos": [
217,
221
]
} |
34 k igf-bp inhibited the binding of [ 125i ] iodo- ( thr59 ) igf-i to jeg-3 monolayers in a concentration-dependent manner by forming with the tracer a soluble complex that could not bind to the cell surface as demonstrated by competitive binding and cross-linking experiments . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
5,
8
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
62,
67
]
} |
in contrast , an intensely labeled band at 40 k was detected when the incubation medium was analyzed , suggesting that ( thr59 ) igf-i and 34 k igf-bp formed a complex in a 1:1 molar ratio . | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
129,
134
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
144,
147
]
} |
also , 34 k igf-bp inhibited both basal and igf-i-stimulated uptake of alpha- [ 3h ] aminoisobutyric acid in jeg-3 cells . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
12,
15
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
44,
49
]
} |
this response to glucocorticoids was blocked by the glucocorticoid receptor antagonist ru 486 , indicating a steroid receptor-mediated process . | NA | {
"id": "C0034809",
"name": "glucocorticoid receptor",
"pos": [
52,
75
]
} | {
"id": "C0034840",
"name": "steroid",
"pos": [
109,
116
]
} |
these results demonstrate that gh4c1 cells may have the genetic information necessary for dopaminergic inhibition of prl synthesis , but that the dopamine response is not observed under standard tissue culture conditions . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
90,
102
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
146,
154
]
} |
lhrh release was measured in hypothalamic/median eminence perfusates , while levels of pituitary gonadotropins ( lh , fsh ) were determined in sequential blood samples obtained via atrial catheters . | NA | {
"id": "C0018066",
"name": "pituitary gonadotropins",
"pos": [
87,
110
]
} | {
"id": "C0023607",
"name": "lh",
"pos": [
113,
115
]
} |
the effects of bfgf on prl secretion are potentiated by the addition of estradiol ( maximally effective dose 100 pg/ml approximately 10 ( -10 ) m ) and are further increased by the addition of the phorbol ester , phorbol myristate acetate . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
197,
210
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
213,
220
]
} |
epinephrine had only a small effect in the microperifusion system , but both epinephrine and norepinephrine had potencies comparable to avp in the static suspension and monolayer systems . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
93,
107
]
} |
stable expression of high levels of activated forms of haras ( t24 ) or v-ki-ras by transfection of chinese hamster lung fibroblasts ( ccl39 ) yielded cells highly tumorigenic in nude mice . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
121,
132
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
151,
156
]
} |
plasmodium falciparum merozoites are covered with polymorphic proteins that are processed from a 190 kd ( p190 ) precursor protein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
62,
70
]
} | {
"id": "C0033665",
"name": "precursor protein",
"pos": [
113,
130
]
} |
we obtained antibodies detecting all isolates tested and a monoclonal antibody specific for isolates containing a k1 type allele of the p190 gene . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
12,
22
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
59,
78
]
} |
at the isoelliptic point , the drug complex with b dna exhibits positive ellipticity while with z dna it exhibits negative ellipticity . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
51,
54
]
} | {
"id": "C0043442",
"name": "z dna",
"pos": [
96,
101
]
} |
as the nadph was exhausted , the spectrum of oxidized enzyme , e , did not reappear but rather a spectrum similar to that previously assigned to an nadp+ complex of two-electron-reduced enzyme , eh2-nadp+ . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
54,
60
]
} | {
"id": "C0026741",
"name": "complex",
"pos": [
154,
161
]
} |
the present state of ms in coronary heart disease is discussed for single and multivessel disease , previous infarction , and risk stratification ( myocardial washout , pulmonary uptake , ischemic dilation , absent heart sign ) , reflecting the importance of the procedure in exercise-induced ischemia as well as in ischemia at rest for prognostication of the natural and therapeutic course , i.e. , therapy control ( angioplasty , bypass , lysis , cardiac drugs ) . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
109,
119
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
316,
324
]
} |
the evaluation of myocardial glucose and fatty acid metabolism with 18f-deoxyglucose ( fdg ) and 11c-palmitate has proved to be clinically useful . | NA | {
"id": "C0011501",
"name": "deoxyglucose",
"pos": [
72,
84
]
} | {
"id": "C0046056",
"name": "fdg",
"pos": [
87,
90
]
} |
following a lag time of 15.5 min ( tablets ) and 4.2 min ( drops ) , which were significantly different , the absorption of oral chlordesmethyldiazepam was a first order process , with apparent absorption half-life values averaging 1.5 h ( tablets ) and 1.1 h ( drops ) . | NA | {
"id": "C0000854",
"name": "absorption",
"pos": [
110,
120
]
} | {
"id": "C1373172",
"name": "absorption half-life",
"pos": [
194,
214
]
} |
to investigate the means by which doxapram affects the control of ventilation , ventilatory function and p0.1 have been related to serum doxapram concentration during a 45-min infusion of doxapram hydrochloride in 7 healthy , conscious subjects under normoxic conditions . | NA | {
"id": "C0013084",
"name": "doxapram",
"pos": [
34,
42
]
} | {
"id": "C0282152",
"name": "doxapram hydrochloride",
"pos": [
188,
210
]
} |
the number of splenic bfu-e , however , was not affected by administration of lps and/or epo or by adsorbed endotoxin . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
78,
81
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
108,
117
]
} |
an agonist of mu-opiate receptors , d-ala2-gly-ol5-enkephalin ( dago , 0.5 mcg ) , administered intrathecally , was found to inhibit behavioral and hemodynamic reactions induced by thermal and electrical stimulation of conscious male rats . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
51,
61
]
} | {
"id": "C0525773",
"name": "dago",
"pos": [
64,
68
]
} |
gaba-mimetics ( muscimol , baclofen , aminooxyacetic acid ) as well as gaba system antagonists ( bicuculline , thiosemicarbazide ) attenuated ketamine action at the level of dh and especially fc . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
0,
4
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
27,
35
]
} |
one of the mechanisms of cyanamide toxic effect may be accumulation of different aldehydes including acetaldehyde . | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
81,
90
]
} | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
101,
113
]
} |
one of these , the ubb subfamily , includes a functional gene coding for a polyubiquitin protein that contains three ubiquitin copies tandemly repeated , as well as three pseudogenes of the processed type . | NA | {
"id": "C0084133",
"name": "polyubiquitin",
"pos": [
75,
88
]
} | {
"id": "C0041538",
"name": "ubiquitin",
"pos": [
117,
126
]
} |
immunoblotting technique confirmed that the purified epidermal pai is reactive with anti-pai-2 , but not with anti-pai-1 . | NA | {
"id": "C0032145",
"name": "pai",
"pos": [
63,
66
]
} | {
"id": "C0030191",
"name": "pai-2",
"pos": [
89,
94
]
} |
immunoblotting technique confirmed that the purified epidermal pai is reactive with anti-pai-2 , but not with anti-pai-1 . | NA | {
"id": "C0032145",
"name": "pai",
"pos": [
63,
66
]
} | {
"id": "C0030190",
"name": "pai-1",
"pos": [
115,
120
]
} |
structural comparison revealed that shv-2 differed from shv-1 by only one amino acid , gly -- -- ser , at position 213 of the mature protein . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
74,
84
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
87,
90
]
} |
both proteins are inhibited and labeled by diisocyanatostilbenedisulfonate ( dids ) , both transport cl- and hco-3 , and both are membrane proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
5,
13
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
130,
147
]
} |
direct comparison of the primary structure of neutral endopeptidase ( nep , ec 3.4.24.11 ) with that of thermolysin , a bacterial metalloendopeptidase with a similar specificity , has revealed very few similarities between the two sequences , except for two conserved short segments . | NA | {
"id": "C0039815",
"name": "thermolysin",
"pos": [
104,
115
]
} | {
"id": "C1442934",
"name": "metalloendopeptidase",
"pos": [
130,
150
]
} |
the primary translation product ( cross-reacting with anti-lipoprotein antiserum ) is a precursor which is converted into a lower molecular mass species of the size of mature lipoprotein by the addition of inverted membrane vesicles from e. coli . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
59,
70
]
} | {
"id": "C0065058",
"name": "a",
"pos": [
220,
221
]
} |
using a series of chromatographic steps , including deae-cellulose chromatography , sephadex g150 gel filtration and reverse phase fast protein liquid chromatography , this phosphoprotein was purified 3800-fold from rat brain . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
136,
143
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
173,
187
]
} |
alkylating oligonucleotide derivatives react with the complementary sequences in hybrid m13mp7 bacteriophage single-stranded dna and destroy the infecting ability of the dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
109,
128
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
170,
173
]
} |
these steroids have substantial effects on lipids and lipoproteins that appear to be primarily related to chemical structure of the compound , dosage , and a patient 's hormonal status . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
43,
49
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
54,
66
]
} |
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