text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the anti-idiotypic igg inhibited the binding of 125i-labeled alpha 2m-trypsin complexes to normal rat kidney fibroblasts , and a kd of 194 pm for the binding of the anti-idiotype to these cells was derived from a fit of the data to a model involving a single class of sites . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
109,
120
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
188,
193
]
} |
the soluble egg dynein is , therefore , closely related to axonemal dynein and may be a ciliary precursor . | NA | {
"id": "C0013352",
"name": "dynein",
"pos": [
16,
22
]
} | {
"id": "C1180333",
"name": "axonemal dynein",
"pos": [
59,
74
]
} |
however , hmr-3 can be distinguished from the soluble cytoplasmic dynein on the basis of its weak cross-reactivity with antiflagellar dynein antibodies , its heavy chain composition on high resolution sodium dodecyl sulfate-polyacrylamide gel electrophoresis , its low specific atpase activity , and the molecular weight of its vanadate-induced uv cleavage fragments . | NA | {
"id": "C1180334",
"name": "cytoplasmic dynein",
"pos": [
54,
72
]
} | {
"id": "C0013352",
"name": "dynein",
"pos": [
134,
140
]
} |
certain lysophospholipids , lysophosphatidylcholine ( lyso-pc ) in particular , stimulated protein kinase c at low concentrations ( less than 20 microm ) but , conversely , inhibited it at high concentrations ( greater than 30 microm ) . | NA | {
"id": "C0024367",
"name": "lysophospholipids",
"pos": [
8,
25
]
} | {
"id": "C0024360",
"name": "lysophosphatidylcholine",
"pos": [
28,
51
]
} |
endothelial cell cultures incubated with peg-superoxide dismutase and peg-catalase for 24 h and then extensively washed were protected from the damaging effects of reactive oxygen species derived from exogenous xanthine oxidase as judged by two criteria : decreased release of intracellular 51cr-labeled proteins and free radical-induced changes in membrane fluidity , measured by electron paramagnetic resonance spectroscopy of endothelial membrane proteins covalently labeled with 4-maleimido-2,2,6,6-tetramethylpiperidinooxyl . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
304,
312
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
441,
458
]
} |
the role of the asparagine-linked oligosaccharides of the alpha subunit in the secretion and assembly of human chorionic gonadotrophin . | NA | {
"id": "C0017963",
"name": "alpha subunit",
"pos": [
58,
71
]
} | {
"id": "C0018062",
"name": "human chorionic gonadotrophin",
"pos": [
105,
134
]
} |
in chinese hamster ovary ( cho ) fibroblast cells the protein kinase c activating phorbol ester , phorbol myristate acetate ( pma ) , stimulates an increase in cell surface transferrin receptor ( tr ) expression by increasing the exocytic rate of the recycling pathway . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
82,
95
]
} | {
"id": "C0039654",
"name": "phorbol myristate acetate",
"pos": [
98,
123
]
} |
in both hela and rat embryo fibroblasts , the synthesis and migration of the major stress-induced 72-kd protein into the nucleolus and its subsequent exit was markedly faster in the tolerant cells as compared with the nontolerant cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
28,
39
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
230,
235
]
} |
to investigate the physiologic role of gelsolin in cells , we have studied the location and mobility of gelsolin in a mouse fibroblast cell line ( c3h ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
51,
56
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
124,
134
]
} |
( 1987 ) demonstrated that the cell surface urokinase of human fibroblasts and fibrosarcoma cells is deposited underneath the cells in strands , apparently at sites of cell-to-substratum contact . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
63,
74
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
168,
172
]
} |
the urokinase strands on ht 1080 fibrosarcoma cells are more numerous and have shapes that are more tortuous than those on normal fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
46,
51
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
130,
141
]
} |
one is the central cell-binding domain that is recognized by a variety of cell types , including fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
19,
23
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
97,
108
]
} |
attachment and trophoblast outgrowth on these substrates can be inhibited by addition to the culture medium of an antibody , anti-ecmr ( anti-extracellular matrix receptor ) , that recognizes a group of 140-kd glycoproteins similar to those of the 140-kd extracellular matrix receptor complex ( integrin ) recognized in avian cells by csat and jg22 monoclonal antibodies . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
114,
122
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
349,
359
]
} |
immunofluorescence experiments show that both the ecmr antigens and the cytoskeletal proteins vinculin and talin are enriched on the cell processes and ventral surfaces of trophectoderm cells in embryo outgrowths , in patterns similar to those seen in fibroblasts , and consistent with their role in adhesion of the trophoblast cells to the substratum . | NA | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
72,
93
]
} | {
"id": "C0085175",
"name": "vinculin",
"pos": [
94,
102
]
} |
immunofluorescence experiments show that both the ecmr antigens and the cytoskeletal proteins vinculin and talin are enriched on the cell processes and ventral surfaces of trophectoderm cells in embryo outgrowths , in patterns similar to those seen in fibroblasts , and consistent with their role in adhesion of the trophoblast cells to the substratum . | NA | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
72,
93
]
} | {
"id": "C0085182",
"name": "talin",
"pos": [
107,
112
]
} |
the preliminary plasma concentration-time and urinary excretion rate-time profiles of hippuric acid and benzoic acid from a healthy subject receiving small , medium and large doses of sodium benzoate are reported . | NA | {
"id": "C0053225",
"name": "benzoic acid",
"pos": [
104,
116
]
} | {
"id": "C0142805",
"name": "sodium benzoate",
"pos": [
184,
199
]
} |
insulin gene expression was quantified by measuring insulin mrna by blot hybridization analysis using a [ 32p ] cdna probe encoding human insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
132,
145
]
} |
a 3-month-old female leprechaun demonstrated extreme insulin resistance with hyperinsulinemia ( 330 mumol/l ) and resistance to exogenous insulin . | NA | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
53,
71
]
} | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
77,
93
]
} |
we tested the serum of 24 patients with graves ' ophthalmopathy , 10 patients with a history of graves ' hyperthyroidism and no eye disease , 14 patients with hashimoto 's thyroiditis without eye disease , 8 patients with other nonautoimmune thyroid disorders , and 20 normal subjects for reactivity with an affinity-purified nonprotein orbital antigen . | NA | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
105,
120
]
} | {
"id": "C0040128",
"name": "thyroid",
"pos": [
242,
249
]
} |
this study of the california psychological inventory ( cpi ) demonstrates that subjects can alter significantly their cpi profiles through role-playing high gender identification , i.e. , males attempt to appear more masculine and women attempt to appear more feminine . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
157,
163
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
188,
193
]
} |
this finding is discussed in the context of other research that supports a premature aging hypothesis . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
5,
12
]
} | {
"id": "C0231341",
"name": "premature aging",
"pos": [
75,
90
]
} |
if immunological detection of 5ht is used alone as a marker for carcinoid tumours problems arise in the differentiation of carcinoid tumours from adenocarcinomas which may also contain 5ht . | NA | {
"id": "C0007095",
"name": "carcinoid tumours",
"pos": [
64,
81
]
} | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
146,
161
]
} |
dna positive cells were focally distributed in the invasive tumours , and most tumour cells were negative for viral dna , a result consistent with the low copy number found in malignant cells . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
0,
3
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
110,
119
]
} |
three mouse monoclonal antibodies ( rff-vii/1 , rff-vii/2 , and rff-vii/3 ) which bind specifically to different epitopes on human factor vii antigen were raised . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
113,
121
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
142,
149
]
} |
hrp-wga-labeled axons in corneal whole mounts were identified by the presence within their axoplasm of linear arrays of hrp-tmb reaction product , and their distribution was plotted faithfully onto line drawings made with a drawing tube attachment . | NA | {
"id": "C0078473",
"name": "hrp-wga",
"pos": [
0,
7
]
} | {
"id": "C0019941",
"name": "hrp",
"pos": [
120,
123
]
} |
in the same animals , cortical connections of subdivisions of auditory cortex were determined by placing injections of the tracer wheat germ agglutinin conjugated with horseradish peroxidase ( wga-hrp ) into electrophysiologically defined locations . | NA | {
"id": "C0019941",
"name": "horseradish",
"pos": [
168,
179
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
193,
200
]
} |
it is concluded that neurons in the ventrolateral medulla and pons , some of which presumably utilize norepinephrine and/or epinephrine as a transmitter , could regulate autonomic function via direct projections to the nucleus tractus solitarii . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
102,
116
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
124,
135
]
} |
distributions of neurons located in the central rostral mesencephalon and caudal diencephalon that project to the upper cervical spinal cord , vestibular nuclei , or inferior olive were studied in the cat by using retrograde axonal transport of wheat germ agglutinin conjugated to horseradish peroxidase ( wga-hrp ) . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
281,
303
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
306,
313
]
} |
the distribution of cells in the rostral medial mesencephalon and caudal diencephalon which project to the vestibular complex was mapped in the cat by using retrograde axonal transport of wheat germ agglutinin conjugated to horseradish peroxidase ( wga-hrp ) . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
224,
246
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
249,
256
]
} |
the present study was designed to evaluate the simultaneous presence of epinephrine ( e ) , norepinephrine ( ne ) , met-enkephalin ( me ) - , somatostatin ( srif ) - and substance p ( sp ) - like immunoreactivities ( li ) in extracts of 12 pheochromocytomas obtained at the time of surgery from 10 patients . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
72,
83
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
92,
106
]
} |
high pressure liquid chromatography ( hplc ) elution of enkephalin immunoreactivity matched that of synthetic methionine-enkephalin , leucine-enkephalin , and methionine-sulfoxide-enkephalin standards . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
56,
66
]
} | {
"id": "C0014294",
"name": "leucine-enkephalin",
"pos": [
134,
152
]
} |
high pressure liquid chromatography ( hplc ) elution of enkephalin immunoreactivity matched that of synthetic methionine-enkephalin , leucine-enkephalin , and methionine-sulfoxide-enkephalin standards . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
56,
66
]
} | {
"id": "C0014295",
"name": "methionine",
"pos": [
159,
169
]
} |
enkephalin concentration in phaeochromocytoma closely paralleled the epinephrine , but not the norepinephrine content of the tumours . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
69,
80
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
95,
109
]
} |
in contrast to native pc , only 1 to 2 h are required for the peptide fragment pc 81-104 to become associated with b cells in a stimulatory fashion , and this time is similar for live and paraformaldehyde-fixed b cells , which can not internalize or process the peptide . | NA | {
"id": "C0030935",
"name": "peptide",
"pos": [
62,
69
]
} | {
"id": "C0030956",
"name": "peptide",
"pos": [
262,
269
]
} |
however , addition of allogeneic spleen cells allowed a t cell proliferative response and prevented the induction of subsequent unresponsiveness . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
22,
32
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
58,
62
]
} |
iga responses were highest and igm responses lowest at the lowest tnp-klh concentrations suggesting that the precursors of the iga pfc have higher average affinity for tnp than the precursors of igm pfc . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
55,
58
]
} | {
"id": "C0018956",
"name": "precursors",
"pos": [
181,
191
]
} |
substantial levels of il-2 responsiveness were induced in t8+ cells by lectin , con a , mab directed against the cd3 ag , okt3 , ca2+ ionophore , ionomycin or phorbol ester , pma . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
159,
172
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
175,
178
]
} |
the hsv-infected glutaraldehyde-fixed fibroblasts therefore induce ifn-alpha 2 mrna in infrequent but highly efficient pbl , each cell capable of producing as much as 2 antiviral units of ifn-alpha . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
38,
49
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
130,
134
]
} |
in contrast , peritoneal b cells from nzb and balb/c mice were stimulated to incorporate tritiated thymidine by each of the phorbol esters , pma and phorbol dibutyrate , acting alone . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
124,
138
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
141,
144
]
} |
the different effects of 24g2 on b cell activation by intact h delta a/1 and h delta a/1 fab/fc were not a result of differences in the abilities of the intact antibody and its fab/fc fragment to activate b cells , since 24g2 did not interfere with the ability of ams-15 , a igg2a anti-igd mab , to slightly increase b cell sia expression . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
160,
168
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
290,
293
]
} |
after electropheretic transfer of nitrocellulose this protein was shown to be a dna binding molecule by use of a probe of biotin labeled dna . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
78,
83
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
137,
140
]
} |
however , ia+ kc were able to present a peptide fragment of pigeon cytochrome c to a hybridoma , suggesting that although these cells can not process native protein ag , they can present antigenic peptides . | NA | {
"id": "C0030935",
"name": "peptide fragment",
"pos": [
40,
56
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
197,
205
]
} |
the release of il-1 by various inducers , including muramyl dipeptide ( mdp ) and zymosan was also enhanced by nt , suggesting a general modulator role for this neuropeptide . | NA | {
"id": "C0027930",
"name": "nt",
"pos": [
111,
113
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
161,
173
]
} |
by addition of purified c8bp , the thromboxane b2 release was suppressed , indicating that c8bp not only restricts the lytic complement attack , but also regulates the c5b-9-mediated stimulation of target cells . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
125,
135
]
} | {
"id": "C0009545",
"name": "c5b-9",
"pos": [
168,
173
]
} |
a total of 10 +/- 4 % ( mean +/- sd , three experiments ) of 3t3 fibroblasts that had reached confluence in medium without il-3 bound b1.1 antibody and , after an additional approximately 28 days of culture in that medium or in 50 % wehi 3-conditioned medium , 12 +/- 3 % ( mean +/- sd , five experiments ) and 16 +/- 7 % ( mean +/- sd , three experiments ) of the cells , respectively , bound the antibody . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
65,
76
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
365,
370
]
} |
after coculture of bmmc and confluent 3t3 fibroblasts for 28 days in 50 % wehi 3-conditioned medium , followed by dispersal and purification of the cells , 92 +/- 18 % of the mast cells and 92 +/- 16 % ( mean +/- sd , seven experiments ) of the fibroblasts were b1.1+ . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
148,
153
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
245,
256
]
} |
thus , the interactions between mast cells and fibroblasts during coculture alter the biochemical and ag phenotypes of both populations . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
7,
10
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
47,
58
]
} |
the biosynthesis , processing , and assembly of the tcr alpha- and beta-chains with each other and with the cd3 complex were investigated on both cell surface positive ( tcr+cd3- ) and negative ( tcr-cd3- ) cell lines . | NA | {
"id": "C0108779",
"name": "cd3 complex",
"pos": [
108,
119
]
} | {
"id": "C0162681",
"name": "tcr-cd3",
"pos": [
196,
203
]
} |
we show here that in permeabilized , [ 3h ] inositol-labeled mouse b cells the nonhydrolyzable gtp analogue gtp gamma s induces release of inositol phosphates , including inositol trisphosphate . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
139,
158
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
171,
179
]
} |
the hypothesis that cytokines mediate neutrophil emigration induced by endotoxin ( lps ) was studied by examining the potency , the kinetics of neutrophil emigration , and the tachyphylaxis of intradermal sites with il-1 , tnf-alpha and lps . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
71,
80
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
237,
240
]
} |
human ril-1 alpha and il-1 beta , synthetic lipid a , and lps were several orders of magnitude more potent than human rtnf . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
44,
51
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
58,
61
]
} |
il-1 and tnf were then examined as potential secondary mediators of lps-induced emigration by comparing the patterns of tachyphylaxis between lps and il-1 alpha or tnf ; | NA | {
"id": "C0021755",
"name": "il-1",
"pos": [
0,
4
]
} | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
150,
160
]
} |
absorption of the serum with egg homogenate from which protein antigens had been removed by boiling and digestion with proteinase k resulted in a similar reduction of antisurface antibody demonstrating that all the shared epitopes that are recognized are carbohydrate in nature . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
63,
71
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
222,
230
]
} |
with respect to the mr greater than 200,000 and 38,000 antigens , it was demonstrated that these epitopes were present on the same antigens that bear the carbohydrate moieties recognized by antibodies from chronically infected mice . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
55,
63
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
97,
105
]
} |
as a model , the 5af6 id family associated with the balb/c mouse antibody response against the p-azophenyl-arsonate ( ar ) epitope was examined by two-color immunocytochemical staining , allowing the simultaneous detection of both id+ and id- anti-ar afc . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
123,
130
]
} | {
"id": "C0021013",
"name": "id",
"pos": [
239,
241
]
} |
herpes simplex virus ( hsv ) specific immune mediated cytotoxicity may be involved in control of hsv infections and in the tissue damage induced by hsv infection or hsv related skin disease such as herpes associated erythema multiforme . | NA | {
"id": "C0019372",
"name": "hsv infections",
"pos": [
97,
111
]
} | {
"id": "C0019348",
"name": "hsv infection",
"pos": [
148,
161
]
} |
rabbit skin cells , a transformed keratinocyte line , or second passage human neonatal foreskin keratinocytes were grown in culture medium with or without 200 microm acv and were infected with hsv . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
12,
17
]
} | {
"id": "C0022567",
"name": "line",
"pos": [
47,
51
]
} |
total rna was isolated by cscl density gradient centrifugation , and messenger rna ( mrna ) steady-state levels were determined by slot-blot hybridizations with human sequence specific complementary dnas ( cdnas ) . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
6,
9
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
69,
82
]
} |
the degree of antigenic restriction , the immunoglobulin class and subclass response to dietary antigens , and the relationship of antibodies against dietary antigens to iga-containing circulating immune complexes ( cic ) in patients with dh , however , are not known . | NA | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
42,
62
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
131,
141
]
} |
the degree of antigenic restriction , the immunoglobulin class and subclass response to dietary antigens , and the relationship of antibodies against dietary antigens to iga-containing circulating immune complexes ( cic ) in patients with dh , however , are not known . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
131,
141
]
} | {
"id": "C0003313",
"name": "circulating immune complexes",
"pos": [
185,
213
]
} |
the decrease of lipase secretion could worsen the consequences of malabsorption in crohn 's disease of the small intestine . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
66,
79
]
} | {
"id": "C0021831",
"name": "disease of the",
"pos": [
92,
106
]
} |
the immunoglobulin classes of the antibodies were igg and/or igm , and no iga class antibodies were detected . | NA | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
4,
26
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
84,
94
]
} |
it is concluded that the new reversible maoi antidepressant moclobemide is similar to other antidepressants in terms of efficacy but very noticeably superior in terms of tolerance and safety . | NA | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
45,
59
]
} | {
"id": "C1579362",
"name": "other",
"pos": [
86,
91
]
} |
the 32p in brain slice lipids was primarily in polyphosphoinositides , phosphatidylinositol ( pi ) , and phosphatidate ( pa ) . | NA | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
47,
68
]
} | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
71,
91
]
} |
good correlations were found between ( a ) the potencies ( ec50 ) of these anions to stimulate radioligand binding and their permeabilities relative to chloride ; | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
75,
81
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
152,
160
]
} |
intravenous administration of 0.25 mg/kg rifn-gamma resulted in no significant change in the clearance , half-life , or vdss , suggesting that the kinetics of rifn-gamma are linear over the range of doses tested . | NA | {
"id": "C0018517",
"name": "half-life",
"pos": [
105,
114
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
147,
155
]
} |
this assay enabled us to isolate two hybridomas secreting antibodies ( designated 2f4 and 4g12 ) that recognized il-1 alpha and not interleukin-1 beta as judged by the ability of the antibodies to : ( a ) precipitate il-1 alpha , ( b ) inhibit the binding of 125i-il-1 alpha to the il-1 receptor on el4 cells , ( c ) inhibit the biological activity of il-1 alpha as measured in a lectin-induced , il-1-dependent thymocyte proliferation assay . | NA | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
113,
123
]
} | {
"id": "C0021755",
"name": "il-1",
"pos": [
397,
401
]
} |
ester hydrolysis of prodrugs of dyphylline [ 7- ( 2,3-dihydroxypropyl ) theophylline ] followed first-order kinetics in both human and rabbit plasma . | NA | {
"id": "C0013360",
"name": "dyphylline",
"pos": [
32,
42
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
72,
84
]
} |
fecal excretion was the primary route of elimination following both intravenous and oral dosing , accounting for 59 % of the administered intravenous dose and 61 % of the oral dose . | NA | {
"id": "C1373190",
"name": "fecal excretion",
"pos": [
0,
15
]
} | {
"id": "C1373186",
"name": "route of elimination",
"pos": [
32,
52
]
} |
renal excretion of unchanged tap was the predominant route of elimination , as renal clearance was estimated to be between 47 and 89 % of total clearance in the dogs . | NA | {
"id": "C1373187",
"name": "renal excretion",
"pos": [
0,
15
]
} | {
"id": "C1373186",
"name": "route of",
"pos": [
53,
61
]
} |
the expression of these moderate conditioned sacc aversions was antagonized by pretreatments ( i.p . or p.o . ) with benzodiazepine and non-benzodiazepine anxiolytic drugs ( lorazepam , diazepam , chlordiazepoxide , oxazepam , phenobarbital , meprobamate , and chlormezanone ) . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
117,
131
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
197,
213
]
} |
dogs were made dependent on p.o . administered diazepam ( 24 or 36 mg/kg/day ) or nordiazepam ( 18 mg/kg/day ) . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
47,
55
]
} | {
"id": "C0011279",
"name": "nordiazepam",
"pos": [
82,
93
]
} |
the mu-selective agonist [ d-ala2 , n-methyl-phe4 , gly5-ol ] enkephalin ( dago ) , the delta-selective agonist [ d-pen2 , d-pen5 ] enkephalin ( dpdpe ) and the reference mu-acting agonist morphine , all produced antinociception after either i.c.v . or intrathecal ( ly ) ( i.t . ) administration . | NA | {
"id": "C0525773",
"name": "dago",
"pos": [
75,
79
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
132,
142
]
} |
the mu-selective agonist [ d-ala2 , n-methyl-phe4 , gly5-ol ] enkephalin ( dago ) , the delta-selective agonist [ d-pen2 , d-pen5 ] enkephalin ( dpdpe ) and the reference mu-acting agonist morphine , all produced antinociception after either i.c.v . or intrathecal ( ly ) ( i.t . ) administration . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
62,
72
]
} | {
"id": "C0525856",
"name": "dpdpe",
"pos": [
145,
150
]
} |
adrenal epinephrine concentrations were similar in shr and wky rats , whereas ne content was elevated in the shr at 46 and 81 days of age . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
8,
19
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
78,
80
]
} |
muscimol , but not baclofen , reduced the ca++-dependent release of [ 3h ] gaba evoked by high k+ in the presence of tetrodotoxin from l-m preparation of the small intestine preloaded with [ 3h ] gaba . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
19,
27
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
196,
200
]
} |
in normotensive rats , a single i.v . dose of idazoxan ( 300 micrograms kg-1 ) caused an immediate 2-fold increase in plasma concentration of norepinephrine and epinephrine , a transient increase in heart rate but no significant change in map . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
142,
156
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
161,
172
]
} |
as regards to the anion selectivity for the stimulation by excitatory amino acids , br- was fully effective as cl- , whereas f- and so42- were ineffective . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
18,
23
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
147,
148
]
} |
further analysis of the myocardial phosphoinositide pathway revealed an additional increase in inositol phosphate and inositol bisphosphate with a concomitant decrease in phosphatidylinositol phosphate and phosphatidylinositol bisphosphate . | NA | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
95,
113
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
218,
226
]
} |
phenylephrine caused a maximal increase in inositol phosphate , inositol bisphospate and ip3 at 10 mmol/l of lithium . | NA | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
43,
61
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
64,
72
]
} |
phenylephrine caused a maximal increase in inositol phosphate , inositol bisphospate and ip3 at 10 mmol/l of lithium . | NA | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
43,
61
]
} | {
"id": "C0021549",
"name": "ip3",
"pos": [
89,
92
]
} |
at high concentrations , alpha-neta activated acetylcholinesterase ( ec50 , 360 microm ) and inhibited cholinesterase ( ec50 , 1100 microm ) . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
46,
66
]
} | {
"id": "C0008429",
"name": "cholinesterase",
"pos": [
103,
117
]
} |
the dihydropyridine ( dhp ) and non-dhp calcium channel antagonists diltiazem , verapamil . and nifedipine differentially and significantly reduced , while the dhp calcium channel agonist , bay k8644 , significantly enhanced the inhibitory effects of the magnetic fields on morphine-induced analgesia . | NA | {
"id": "C2945601",
"name": "dhp calcium channel",
"pos": [
36,
55
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
96,
106
]
} |
the dihydropyridine ( dhp ) and non-dhp calcium channel antagonists diltiazem , verapamil . and nifedipine differentially and significantly reduced , while the dhp calcium channel agonist , bay k8644 , significantly enhanced the inhibitory effects of the magnetic fields on morphine-induced analgesia . | NA | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
96,
106
]
} | {
"id": "C0012315",
"name": "dhp",
"pos": [
160,
163
]
} |
additional cases of adenomyoma in infertile women need to be reported on before light is shed on its causal relationship to infertility as well as on its diagnosis and management . | NA | {
"id": "C0021361",
"name": "infertile",
"pos": [
34,
43
]
} | {
"id": "C0021359",
"name": "infertility",
"pos": [
124,
135
]
} |
intact sf and cell depleted sf were found to suppress chondrocyte metabolism both in the ra and non-ra group . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
14,
18
]
} | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
54,
65
]
} |
fibroblasts from normal and progressive systemic sclerosis involved skin more closely resemble in vivo cells when cultured in a collagen gel matrix , than do fibroblasts cultured on plastic . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
103,
108
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
158,
169
]
} |
computer-assisted comparison of the x-ray structures of 8 and prazosin suggested that the 4.0 kcal/mol difference in alpha 1-adrenoceptor binding energies was largely due to salt-bridge formation ( ca . 3.0 kcal/mol ) between the protonated quinazoline and the receptor protein . | NA | {
"id": "C0032912",
"name": "prazosin",
"pos": [
62,
70
]
} | {
"id": "C0034407",
"name": "quinazoline",
"pos": [
241,
252
]
} |
these results support the hypothesis that the antihypertensive activity of prazosin , doxazosin , and related derivatives derives solely from alpha 1-adrenoceptor blockade . | NA | {
"id": "C0032912",
"name": "prazosin",
"pos": [
75,
83
]
} | {
"id": "C0114873",
"name": "doxazosin",
"pos": [
86,
95
]
} |
a series of unsymmetrically substituted 4-phenyl-1,4-dihydropyridine calcium entry blockers were investigated for their ability to relax potassium-contracted rabbit aortic smooth muscle and to competitively displace [ 3h ] nitrendipine from its specific binding sites on guinea pig myocardial membranes in order to delineate the pharmacologically active conformer with respect to the position of the aromatic substituent ( synperiplanar or antiperiplanar ) . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
53,
68
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
223,
235
]
} |
whereas the introduction of phenylalanine , alanine , or ornithine residues in position 31 led to compounds that still displayed peripheral agonist properties , the presence of a negative charge in the side chain of the amino acid in position 31 prevented the binding of the peptide to both pancreatic and brain binding sites . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
34,
41
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
220,
230
]
} |
derivatives were successfully obtained with both neutral ( leu , val , ala , ile , trp , tyr , gly ) and one acidic ( glu ) amino acids . | NA | {
"id": "C0017890",
"name": "gly",
"pos": [
95,
98
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
124,
135
]
} |
dietary carotenoids consist of individual retinoids -- pro-vitamin a precursors and non-pro-vitamin a precursors-displaying different biological activity . | NA | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
8,
19
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
42,
51
]
} |
our investigation sought to assess how several anthropometric measures ( weight , length , head circumference , arm : head circumference ratio , and tricep skinfold ) and serum albumin , transthyretin , and transferrin concentrations reflect protein and energy intake . | NA | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
171,
184
]
} | {
"id": "C0032923",
"name": "transthyretin",
"pos": [
187,
200
]
} |
physical mixtures of long chain triglyceride ( lct ) and/or medium chain triglyceride ( mct ) were added to the tissue culture medium so that the final concentration was 400 mg/dl . | NA | {
"id": "C0041004",
"name": "triglyceride",
"pos": [
32,
44
]
} | {
"id": "C0724624",
"name": "medium chain triglyceride",
"pos": [
60,
85
]
} |
the addition of lct to mct caused a dose-related decrease in adipose tissue prostaglandin production . | NA | {
"id": "C0041004",
"name": "lct",
"pos": [
16,
19
]
} | {
"id": "C0724624",
"name": "mct",
"pos": [
23,
26
]
} |
plasma concentrations of noradrenaline ( na ) and adrenaline ( a ) were measured before and during leg exercise . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
25,
38
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
50,
60
]
} |
the sequential changes in 24-hour urinary norepinephrine ( ne ) and epinephrine ( e ) excretion levels were measured in spontaneously hypertensive rats ( shr ) that received deoxycorticosterone acetate ( doca ) and 1 % nacl drinking water . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
42,
56
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
68,
79
]
} |
blood pressure , ne and e increased progressively in doca-shr group , and ne ( 2392 +/- 94 vs. 998 +/- 49 ng/day ) and e ( 250 +/- 21 vs. 116 +/- 6 ng/day ) exceeded twice that of the control shr group in the sixth week of doca treatment . | NA | {
"id": "C0011710",
"name": "doca",
"pos": [
53,
57
]
} | {
"id": "C0813203",
"name": "doca",
"pos": [
223,
227
]
} |
in wky rats , ne ( 1372 +/- 48 vs. 968 +/- 37 ng/day ) and e ( 147 +/- 9 vs. 121 +/- 7 ng/day ) levels were significantly higher in rats given doca than those in control group in the sixth week of the treatment , but were not so remarkably high as in doca-shr group . | NA | {
"id": "C0813203",
"name": "doca",
"pos": [
143,
147
]
} | {
"id": "C0011710",
"name": "doca",
"pos": [
251,
255
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.