text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
consistent with previous reports , typical barbiturates ( pentobarbital , secobarbital , phenobarbital ) produced dose-dependent increases in the number of shocks received at doses which did not depress background responding ( water intake ) . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
43,
55
]
} | {
"id": "C0036516",
"name": "secobarbital",
"pos": [
74,
86
]
} |
the benzodiazepine receptor ( bzr ) is a site on the gabaa-receptor-chloride channel by means of which benzodiazepine and nonbenzodiazepine compounds produce positive or negative allosteric modulation of the channel gating function and which is blocked by bzr antagonists . | NA | {
"id": "C0034807",
"name": "gabaa-receptor",
"pos": [
53,
67
]
} | {
"id": "C0055363",
"name": "chloride",
"pos": [
68,
76
]
} |
out of a number of putative endogenous compounds with affinity for the bzr , the peptide dbi ( diazepam binding inhibitor ) stands out as a ligand that might act on the bzr in a subset of gabaergic synapses or under particular situations . | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
81,
88
]
} | {
"id": "C0057738",
"name": "diazepam binding",
"pos": [
95,
111
]
} |
by a mechanical hindrance , using a membrane technique , fibroblasts and other soft connective-tissue cells are prevented from entering the bone defect so that the presumably slower-migrating cells with osteogenic potential are allowed to repopulate the defect . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
57,
68
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
192,
197
]
} |
473 cases of death by drowning were examined for evidence of previous neurological disorders linked with the occurrence of epileptic fits . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
13,
18
]
} | {
"id": "C0013142",
"name": "drowning",
"pos": [
22,
30
]
} |
rapid-cycling bipolar patients have a high prevalence of hypothyroidism , and this disturbance in their hypothalamic-pituitary-thyroid ( hpt ) function may provide a model for understanding the less severe thyroid dysfunction present in other forms of affective disorder . | NA | {
"id": "C0020676",
"name": "hypothyroidism",
"pos": [
57,
71
]
} | {
"id": "C0040128",
"name": "thyroid",
"pos": [
206,
213
]
} |
in experiments with model plant tumors ( kalanchoe-ti plasmid agrobact . tumefaciens c-58d ) it was shown that exposure of the recipient plant to low-level gamma-radiation of 2 gy induced changes in cells that were not repaired over two months promoting tumoral transformations in them . | NA | {
"id": "C0027659",
"name": "experiments",
"pos": [
3,
14
]
} | {
"id": "C0027651",
"name": "tumoral",
"pos": [
254,
261
]
} |
ribo- and deoxyribonucleosides and nucleotides of guanine , uracil , thymine , and cytosine have no protective action . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
60,
66
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
69,
76
]
} |
the spectra from brains of healthy volunteers ( n = 5 ) showed resonances from n-acetylaspartate , glutamine , aspartate , phosphocreatine/creatine , choline , taurine , and glycine . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
123,
138
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
139,
147
]
} |
in five large brain meningiomas , resonances from n-acetyl-aspartate and phosphocreatine/creatine were either not visible or markedly decreased in intensity . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
73,
88
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
89,
97
]
} |
the spectra from livers of three healthy volunteers showed resonances from aliphatic and aromatic amino acids , choline , carnitine , and both saturated and unsaturated fatty acyl chains , and spectra from hearts of six healthy volunteers showed major resonances from phosphocreatine/creatine and taurine and smaller resonances from amino acids and fatty acyl chains . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
268,
283
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
284,
292
]
} |
the spectra from livers of three healthy volunteers showed resonances from aliphatic and aromatic amino acids , choline , carnitine , and both saturated and unsaturated fatty acyl chains , and spectra from hearts of six healthy volunteers showed major resonances from phosphocreatine/creatine and taurine and smaller resonances from amino acids and fatty acyl chains . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
275,
283
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
333,
344
]
} |
behavioural and neuropharmacological properties of the dibenzazepines , desipramine and lofepramine : studies on the olfactory bulbectomized rat model of depression . | NA | {
"id": "C0012029",
"name": "dibenzazepines",
"pos": [
55,
69
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
72,
83
]
} |
behavioural and neuropharmacological properties of the dibenzazepines , desipramine and lofepramine : studies on the olfactory bulbectomized rat model of depression . | NA | {
"id": "C0012029",
"name": "dibenzazepines",
"pos": [
55,
69
]
} | {
"id": "C0023961",
"name": "lofepramine",
"pos": [
88,
99
]
} |
gamma-vinyl gaba ( gvg ) is a new anticonvulsant drug that enhances levels of gaba in the brain by irreversibly inhibiting gaba transaminase . | NA | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
0,
16
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
123,
127
]
} |
to further evaluate the effects and mechanism of action of gvg in the human brain , we measured acetylcholinesterase ( ache ) activity and levels of homovanillic acid ( hva ) , 5-hydroxyindoleacetic acid ( 5-hiaa ) , cyclic nucleotides ( camp , cgmp ) , total gaba ( tgaba ) , and gvg in csf of 78 patients with complex partial epilepsy . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
260,
264
]
} | {
"id": "C0048044",
"name": "gvg",
"pos": [
281,
284
]
} |
the following factors correlated with more emotional feelings towards pregnancy and higher intensity of in-labor pain : ( a ) parity , ( b ) younger age , ( c ) less education , ( d ) more menstrual problems , ( e ) history of abortion , ( f ) unstable emotional feelings , ( g ) unrealistic expectations of pain and discomfort , ( h ) more pain relieving drugs during labor and delivery , and ( i ) a mate with negative or indifferent feelings toward the pregnancy . | NA | {
"id": "C0474368",
"name": "labor pain",
"pos": [
107,
117
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
341,
345
]
} |
molecular sieve chromatography on bio-gel p-10 showed that while most of the somatostatin in the antrum was somatostatin-14 , in the duodenum about 30 % of the total immunoreactivity was somatostatin-28 . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
108,
123
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
187,
202
]
} |
using antisera specific for nh2-terminal and cooh-terminal regions of substance p and for the cooh-terminal region of neurokinin a , peptides with tachykinin-like immunoreactivity were isolated from extracts of chicken small intestine . | NA | {
"id": "C0038585",
"name": "substance",
"pos": [
70,
79
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
147,
157
]
} |
using antisera specific for nh2-terminal and cooh-terminal regions of substance p and for the cooh-terminal region of neurokinin a , peptides with tachykinin-like immunoreactivity were isolated from extracts of chicken small intestine . | NA | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
118,
130
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
147,
157
]
} |
the effect of adenosine on respiration and respiratory chemosensitivity in awake animals was studied in rats , intact and chemodenervated , before and after intra-peritoneal injection of l-phenylisopropyladenosine ( pia ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
14,
23
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
189,
213
]
} |
lower respiratory tract infections in children , including group , bronchiolitis , and bronchitis are frequently associated with recurrent episodes of wheezing . | NA | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
67,
80
]
} | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
87,
97
]
} |
preincubation of pbmcs with sle igg at 0.5-1.0 mg for 24 h followed by washing and subsequent cell culture for 7 days resulted in marked relative increase in cell supernatant igg . | NA | {
"id": "C1321301",
"name": "pbmcs",
"pos": [
17,
22
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
158,
162
]
} |
we investigated the mechanism of cartilage degradation by pancreatic elastase as a model system for the action of cationic proteases such as leukocyte elastase and cathepsin-g . | NA | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
58,
77
]
} | {
"id": "C0064833",
"name": "leukocyte elastase",
"pos": [
141,
159
]
} |
all but two of the patients with active inflammatory bowel disease , whether crohn 's disease or ulcerative colitis , had an abnormal ratio . | NA | {
"id": "C0021390",
"name": "inflammatory bowel disease",
"pos": [
40,
66
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
77,
93
]
} |
albumin was converted to all c2-c5-fatty acids , whereas amino acids generally were converted to specific scfa , most often through the combination of a deamination and decarboxylation of the amino acids , although more complex processes also took place . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
35,
46
]
} | {
"id": "C0015691",
"name": "scfa",
"pos": [
106,
110
]
} |
cell sorter-purified small splenic l3t4+ cells from b6 mice were clonally expanded under limiting dilution ( ld ) conditions by coculture for 4-6 days with irradiated allogeneic stimulator cells in culture medium supplemented with various growth factor preparations . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
41,
46
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
167,
177
]
} |
we report that certain cytokines ( interleukin 1 ( il-1 alpha , il-1 beta ) and interleukin 2 ( il-2 ] which all activate monocytes , induce the synthesis of thromboplastin ( tpl ) and ( il-1 beta only ) factor vii . | NA | {
"id": "C0021755",
"name": "interleukin 1",
"pos": [
35,
48
]
} | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
51,
61
]
} |
the addition of protein a to the immune complexes ( using intact antibodies ) did not affect the degree of suppression . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
33,
49
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
65,
75
]
} |
with this formula we obtained 71.4 % reliability in predicting foetal weight with a mean absolute weight difference of 221 g for the complete study group . | NA | {
"id": "C0751992",
"name": "foetal weight",
"pos": [
63,
76
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
98,
104
]
} |
exposure of escherichia coli to low concentrations of hydrogen peroxide results in dna damage that causes mutagenesis and kills the bacteria , whereas higher concentrations of peroxide reduce the amount of such damage . | NA | {
"id": "C0020281",
"name": "hydrogen peroxide",
"pos": [
54,
71
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
176,
184
]
} |
insulin receptor complementary dna has been cloned from an insulin-resistant patient with leprechaunism whose receptors exhibited multiple abnormalities in insulin binding . | NA | {
"id": "C0265344",
"name": "leprechaunism",
"pos": [
90,
103
]
} | {
"id": "C0000772",
"name": "multiple abnormalities",
"pos": [
130,
152
]
} |
in this report the 3 ' untranslated region of the mrna for the human tfr was shown to be necessary and sufficient for iron-dependent control of mrna levels . | NA | {
"id": "C0600680",
"name": "untranslated region",
"pos": [
23,
42
]
} | {
"id": "C0035696",
"name": "mrna",
"pos": [
144,
148
]
} |
the object of this study was to determine whether the fluid sequestration and potential total body water increase observed in patients with the diagnosis of pancreatitis affects the pharmacokinetics -- and thus dosing requirements -- of the water-soluble aminoglycoside gentamicin . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
255,
269
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
270,
280
]
} |
nutrition of the alien population included mostly simple carbohydrates : sugar , fat and monounsaturated fatty acids . | NA | {
"id": "C0026492",
"name": "simple",
"pos": [
50,
56
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
73,
78
]
} |
the effect of lithium preparations ( lithium carbonate , lithium oxybutyrate ) , calcium channel blocking agents ( verapamil , nifedipine ) , beta 2-adrenoagonist ( salbutamol ) , cromolyn sodium and cimetidine on clinical efficacy and frequency of ulcer cicatrization was assessed in 201 patients ( 33 women , 168 men ) with endoscopically verified stomach ulcer ( 52 patients ) and duodenal ulcer ( 166 patients ) during treatment for 4 weeks as compared to placebo and standard antiulcerative therapy ( cholinolytics , antacids and reparents ) . | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
14,
21
]
} | {
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
37,
54
]
} |
functionally , this abnormal plasminogen is characterized by failure to enhance maximal conversion to plasmin , especially by plasminogen activators , which are enhanced by fibrin or fibrin degradation products . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
173,
179
]
} | {
"id": "C0163275",
"name": "fibrin degradation products",
"pos": [
183,
210
]
} |
the assay was calibrated against a preparation of pure pai-1 whose protein concentration had been determined by amino acid analysis and the detection limit was 30 pg pai-1 ml-1 sample . | NA | {
"id": "C0032145",
"name": "pai-1",
"pos": [
55,
60
]
} | {
"id": "C0030190",
"name": "pai-1",
"pos": [
166,
171
]
} |
specific activity of intracellular pai-1 was typically 20-fold greater than that of pai-1 in 24 h conditioned medium and a t1/2 for inactivation of secreted pai-1 of 0.53 h was calculated . | NA | {
"id": "C0032145",
"name": "pai-1",
"pos": [
35,
40
]
} | {
"id": "C0030191",
"name": "2",
"pos": [
126,
127
]
} |
the latter is due in part to increased levels of the 48 kda plasminogen activator inhibitor ( pai-1 ) present in the plasma of non-pregnant individuals . | NA | {
"id": "C0032145",
"name": "plasminogen activator inhibitor",
"pos": [
60,
91
]
} | {
"id": "C0030190",
"name": "pai-1",
"pos": [
94,
99
]
} |
anticoagulant properties towards an artificial surface of a chemically depolymerized low molecular weight heparin ( lmwh ) have been compared to those of a standard heparin ( sh ) . | NA | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
85,
113
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
165,
172
]
} |
four animals received 150 anti-fxa u/kg followed by 40 anti-fxa u/kg/h of lmwh or 300 iu/kg followed by 100 iu/kg/h of sh . | NA | {
"id": "C0019139",
"name": "lmwh",
"pos": [
74,
78
]
} | {
"id": "C0019134",
"name": "sh",
"pos": [
119,
121
]
} |
after three hours of bypass fibrin deposition occurred in the reservoir in three out of four dogs receiving lmwh while none was observed under sh . | NA | {
"id": "C0019139",
"name": "lmwh",
"pos": [
108,
112
]
} | {
"id": "C0019134",
"name": "sh",
"pos": [
143,
145
]
} |
inactivation of thrombin was enhanced by dextran sulfate ( ds ) coated on polypropylene tubes with plastic adhesive . | NA | {
"id": "C0032582",
"name": "polypropylene",
"pos": [
74,
87
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
99,
106
]
} |
the sites cleaved with the protease were compared to those reported with hemorrhagic proteases from other snake venoms . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
27,
35
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
85,
94
]
} |
interstudy variations in lipoprotein fraction analyzed , methodology for the analysis of lipids and lipoproteins , arterial segment examined , population sampled , control selection in case-control studies , statistical analytic approach taken , and methodology for the assessment of arterial disease preclude pooled analyses . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
89,
95
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
100,
112
]
} |
there is a clear need for further evaluation of this relation using standardized and up-to-date methodologies both for analyses of lipids and lipoproteins and for assessment of cerebrovascular disease in symptom-free volunteers as well as in symptomatic patients . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
131,
137
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
142,
154
]
} |
dihydropyridine calcium channel blockers such as nicardipine are under evaluation for treating acute cerebral ischemia because they may increase cerebral blood flow by causing vasodilation and because they may be cytoprotective in part by limiting production of arachidonic acid metabolites . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium channel blockers",
"pos": [
0,
40
]
} | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
49,
60
]
} |
the ornithine decarboxylase activity and the polyamine content in the fraction of plasma membranes and cytosol of the rat liver are studied in the early period ( 1-4 weeks ) of nitrosodiethyl amine-induced hepatocarcinogenesis . | NA | {
"id": "C0032433",
"name": "polyamine",
"pos": [
45,
54
]
} | {
"id": "C0002508",
"name": "amine",
"pos": [
192,
197
]
} |
the washed cells of hansenula polymorpha and pichia pinus grown on the medium with methanol rapidly acidify the medium during incubation with the mentioned alcohol or formaldehyde . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
83,
91
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
156,
163
]
} |
lysosomal structures in liver parenchymal cells of 3 patients with iron overload and of 3 subjects without iron-storage disorders were investigated . | NA | {
"id": "C0282193",
"name": "iron overload",
"pos": [
67,
80
]
} | {
"id": "C0018995",
"name": "iron-storage disorders",
"pos": [
107,
129
]
} |
traumatology deals with two different types of shock - the early hypovolemic-traumatic , and the late , so called septic shock , which is often associated with multi-organ failure . | NA | {
"id": "C0036974",
"name": "shock",
"pos": [
47,
52
]
} | {
"id": "C0026766",
"name": "multi-organ failure",
"pos": [
160,
179
]
} |
the gut area is less resistant to the events of shock and therefore is a `` '' locus minoris resistentiae '' '' for further development of endotoxemia , bacteremia , septic shock and multi-organ failure without a typical septic focus . | NA | {
"id": "C0376618",
"name": "endotoxem",
"pos": [
139,
148
]
} | {
"id": "C0004610",
"name": ", bacterem",
"pos": [
151,
161
]
} |
five monoclonal antibodies exhibited an identical specific reaction only with bovine thrombocytes , two antibodies reacted only with a certain limited population of bovine spleen cells . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
5,
26
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
104,
114
]
} |
the proposed method of sample preparation is not suitable for the examination of animal-origin foods because some proteins ( albumin ) might interfere . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
114,
122
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
125,
132
]
} |
reduced efficacy of the anthelmintics levamisole and thiabendazole to adult o. ostertagi and of modern benzimidazoles to the inhibited l4 larvae has been reported in cattle . | NA | {
"id": "C0039832",
"name": "thiabendazole",
"pos": [
53,
66
]
} | {
"id": "C0005050",
"name": "benzimidazoles",
"pos": [
103,
117
]
} |
in addition to these , the newer broad-spectrum benzimidazoles and probenzimidazoles , albendazole , febantel , netobimin and oxfendazole , are effective and available in other countries . | NA | {
"id": "C0005050",
"name": "benzimidazoles",
"pos": [
48,
62
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
87,
98
]
} |
there was an excellent agreement between the intracellular immunoglobulin staining as defined by the immunoperoxidase technique and the serum or urinary m-component detected by immunoelectrophoresis . | NA | {
"id": "C0021027",
"name": "immunoglobulin",
"pos": [
59,
73
]
} | {
"id": "C0030490",
"name": "m-component",
"pos": [
153,
164
]
} |
we found that ross river virus possesses an in-phase opal termination codon between nsp3 and nsp4 , whereas in o'nyong-nyong virus this termination codon is replaced by an arginine codon . | NA | {
"id": "C0242611",
"name": "termination codon",
"pos": [
58,
75
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
181,
186
]
} |
we have used a series of synthetic peptides derived from the deduced amino acid sequence of lcmv gp-c to define an antigenic site containing two topographically overlapping epitopes . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
115,
124
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
173,
181
]
} |
reactivity of a second monoclonal , 9-7.9 ( epitope gp-2b ) but not 33.6 , was abolished when substitution of tyrosine for phenylalanine was made at position 375 in the antigenic sequence corresponding to a naturally occurring sequence difference between lcm and lassa viruses . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
44,
51
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
169,
178
]
} |
the linear dna has an interrupted e1 orf and fully transformed cells are obtained also with a subgenomic viral dna fragment containing part of the l1 orf , the complete e6 , e7 , and e8 orfs , and the truncated e1 orf under the control of the bpv-4 regulatory region ; | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
11,
14
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
105,
114
]
} |
in order to characterize these insertions , we have isolated recombinant dna clones from normal rat dna containing all of the normal rat c-myc gene , and from two moloney murine leukemia virus-induced lymphomas containing both proviral and adjacent rat c-myc sequences . | NA | {
"id": "C0012931",
"name": "recombinant dna",
"pos": [
61,
76
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
100,
103
]
} |
additionally , some sleep and arousal disorders must be mentioned , such as narcolepsy , disorders of excessive somnolence associated with sleep-induced respiratory impairment , as well as the kleine-levin-critchley syndrome . | NA | {
"id": "C0027404",
"name": "narcolepsy",
"pos": [
76,
86
]
} | {
"id": "C0020524",
"name": "disorders of excessive",
"pos": [
89,
111
]
} |
additionally , some sleep and arousal disorders must be mentioned , such as narcolepsy , disorders of excessive somnolence associated with sleep-induced respiratory impairment , as well as the kleine-levin-critchley syndrome . | NA | {
"id": "C0020524",
"name": "disorders of excessive",
"pos": [
89,
111
]
} | {
"id": "C0206085",
"name": "kleine-levin-critchley syndrome",
"pos": [
193,
224
]
} |
among other brain diseases manifesting syncope and/or drop attack , cerebrovascular disorders are of major importance in view of their high incidence . | NA | {
"id": "C0006111",
"name": "brain diseases",
"pos": [
12,
26
]
} | {
"id": "C0007820",
"name": "cerebrovascular disorders",
"pos": [
68,
93
]
} |
in the nici mode , [ m - 1 ] - quasi-molecular anions were the base peaks except for trimethadione and paramethadione . | NA | {
"id": "C0022023",
"name": "nici",
"pos": [
7,
11
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
47,
53
]
} |
in the first place there are diseases of the liver ( 30 times primary disease , 28 times secondary disease ) , in which cases 24 times a liver cirrhosis was existing and in 11 cases a coma hepaticum caused death . | NA | {
"id": "C0023895",
"name": "diseases of the liver",
"pos": [
29,
50
]
} | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
137,
152
]
} |
the results of the study of rabbit antisera to meningococci a , b , c in the double diffusion in gel , passive hemagglutination test and enzyme immunoassay with antigenic preparations isolated from s. aureus strains are indicative of the presence of common antigenic determinants of protein and polysaccharide nature in s. aureus and n. meningitidis . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
161,
170
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
257,
279
]
} |
a characteristic feature of epidemic parotitis is the formation of epidemic foci in the absence of parotitis cases and without the penetration of the infective agent from the outside . | NA | {
"id": "C0026780",
"name": "epidemic parotitis",
"pos": [
28,
46
]
} | {
"id": "C0030583",
"name": "parotitis",
"pos": [
99,
108
]
} |
the expedient method has been worked out : the antigen diluted 1:20 with the initial hemolytic activity in the direct hemolysis inhibition test equal to 1:64 and , for its fixation , 0.1 m carbonate-bicarbonate buffer solution , ph 9.6 , are used ; | NA | {
"id": "C0007026",
"name": "carbonate",
"pos": [
189,
198
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
199,
210
]
} |
the study has shown the possibility of using the indirect eia technique for the detection of antibodies to hbsag , both free and bound in immune complexes , of detecting antibodies to hbsag in patients with acute and chronic viral hepatitis b , as well as of simultaneous detection of igg and igm antibodies to hbsag without pseudonegative results . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
138,
154
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
297,
307
]
} |
nine factors have been isolated whose varying combinations were most contributory to the risk of the development of cs in the studied population : cardiac diseases , transient disorder of the cerebral circulation , arterial hypertension , atherosclerosis , aggravated heredity for cardiovascular diseases , intermittent claudication , diabetes mellitus , systematic alcohol abuse , and hypodynamia . | NA | {
"id": "C0003850",
"name": "atherosclerosis",
"pos": [
239,
254
]
} | {
"id": "C0021775",
"name": "intermittent claudication",
"pos": [
307,
332
]
} |
left ventricular systolic time intervals , bupivacaine concentrations , adrenaline and noradrenaline levels were determined in 19 neonates delivered by elective cesarean section . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
72,
82
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
87,
100
]
} |
haemodynamic data and blood samples for determination of plasma renin activity ( pra ) and epinephrine ( e ) and norepinephrine ( ne ) levels were collected before and during hypotension . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
91,
102
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
113,
127
]
} |
our results demonstrate that the cardiovascular effects of higher isoflurane concentrations in the absence of narcotic analgesia are counterbalanced by adrenergic stress stimulation of released epinephrine and norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
194,
205
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
210,
224
]
} |
depletion of vp- and ot-containing axon profiles in the neurohypophysis may suggest increased release of both neurohypophysial hormones in stz-induced diabetes . | NA | {
"id": "C0030095",
"name": "ot",
"pos": [
21,
23
]
} | {
"id": "C0032017",
"name": "neurohypophysial hormones",
"pos": [
110,
135
]
} |
the extent of this increase was gender-dependent : tissues from male rats had significantly higher iga-positive cell densities than those of females . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
32,
38
]
} | {
"id": "C0086582",
"name": "male",
"pos": [
143,
147
]
} |
in 789 courses of antibiotic prophylaxis in hip arthroplasty surgery , either dicloxacillin ( diclocil ) or cloxacillin ( ekvacillin ) was used during two different time periods . | NA | {
"id": "C0012093",
"name": "dicloxacillin",
"pos": [
78,
91
]
} | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
108,
119
]
} |
therefore , this study confirms the hypothesis that cardiac rhabdomyoma is a hamartoma rather than a true neoplasm . | NA | {
"id": "C0018552",
"name": "hamartoma",
"pos": [
77,
86
]
} | {
"id": "C0027651",
"name": "neoplasm",
"pos": [
106,
114
]
} |
depressed patients also showed significant negative correlations between delta max tsh and urinary outputs of norepinephrine and normetanephrine with similar trends with plasma levels of norepinephrine and 3-methoxy-4-hydroxyphenylglycol . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
110,
124
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
129,
144
]
} |
the house dust mite ( dermatophagoides pteronyssinus ) antigen and allergen contents were measured by enzyme-linked immunosorbent assay ( elisa ) with enzyme-labelled anti-human ige and anti-mite rabbit igg antibodies . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
55,
62
]
} | {
"id": "C0002092",
"name": "allergen",
"pos": [
67,
75
]
} |
nisoldipine , a dihydropyridine with calcium channel-blocking activity , was studied in myocardial ischemia and reperfusion in cats . | NA | {
"id": "C0028116",
"name": "nisoldipine",
"pos": [
0,
11
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
16,
31
]
} |
the acute hemodynamic effects of isradipine , a new dihydropyridine calcium antagonist , were evaluated in 16 men referred for elective cardiac catheterization . | NA | {
"id": "C0071304",
"name": "isradipine",
"pos": [
33,
43
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium",
"pos": [
52,
75
]
} |
between november 1980 and november 1985 , 54 patients ages greater than or equal to 70 years underwent percutaneous transluminal coronary angioplasty for unstable angina , defined as recent-onset ( less than 1 month ) angina , new onset of rest angina ( greater than or equal to 2 episodes ) or accelerating class iii or iv angina . | NA | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
154,
169
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
324,
330
]
} |
the cells of the cellular reticulum -- reticular cells and their cytoplasmic processes , which possess abundant contractile microfilaments , dense bodies , hemidesmosomes , basal laminae , and a well-developed , rough-surfaced endoplasmic reticulum , and golgi complexes , which are characteristic of both fibroblasts and smooth muscle cells -- are considered to be myofibroblasts . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
17,
25
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
369,
380
]
} |
maternal consumption of mo vs so reduced ( p less than 0.05 ) fetal body weight and lung weight but not lung : body wt ratio . | NA | {
"id": "C0751992",
"name": "fetal body weight",
"pos": [
62,
79
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
89,
95
]
} |
the following types are described : superficial gastritis , diffuse antral gastritis , postgastrectomy ( reflux ) gastritis , diffuse corporal atrophic gastritis , and multifocal atrophic gastritis . | NA | {
"id": "C0017152",
"name": "gastritis",
"pos": [
48,
57
]
} | {
"id": "C0017154",
"name": "atrophic gastritis",
"pos": [
179,
197
]
} |
plasma triglyceride , cholesterol , low-density lipoprotein-cholesterol , and apoprotein b concentrations were significantly higher ( p = less than 0.05 to less than 0.001 ) in the hypertensive group . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
22,
33
]
} | {
"id": "C0023824",
"name": "low-density lipoprotein-cholesterol",
"pos": [
36,
71
]
} |
in light of this , experiments were performed to assess the relative allergenic potential of four such enzymes : papain , subtilisin a , subtilisin b , and pancreatin . | NA | {
"id": "C0038597",
"name": "subtilisin a",
"pos": [
122,
134
]
} | {
"id": "C0038601",
"name": "subtilisin",
"pos": [
137,
147
]
} |
primates immunized intradermally ( i.d . ) with the four enzymes showed various levels of response to challenges : none to papain , mild to moderate to subtilisin a and pancreatin , and severe to subtilisin b . | NA | {
"id": "C0038597",
"name": "subtilisin",
"pos": [
152,
162
]
} | {
"id": "C0038601",
"name": "subtilisin",
"pos": [
196,
206
]
} |
the decrease in glucose uptake was not compensated for by increased uptake of free fatty acids but was accompanied by decreases in plasma insulin and increases in plasma epinephrine and norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
170,
181
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
186,
200
]
} |
glycine and leucine balances were uniquely more positive across muscle during the infusion of glycylleucine than the corresponding amino acid mixture . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
0,
7
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
131,
141
]
} |
maximal rises of norepinephrine ( ne ) and epinephrine corresponded to 215 and 120 pg/ml above basal values at 2 min in control experiment . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
17,
31
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
43,
54
]
} |
there was no difference in body weight , liver weight , serum creatinine , or urea nitrogen between the two groups . | NA | {
"id": "C0005911",
"name": "difference",
"pos": [
13,
23
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
47,
53
]
} |
it appeared that only micelles of sglc were precipitated and that both the sulfate and the carboxylate anionic groups participated in ca binding . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
75,
82
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
103,
110
]
} |
the present findings indicate that 1 ) interaction with calcium might be responsible for the differential cholestatic properties of sglc and stlc and 2 ) binding of sulfated lithocholic acid conjugates to insoluble calcium phosphate in the intestinal lumen is likely to prevent their accumulation in the enterohepatic circulation . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
56,
63
]
} | {
"id": "C0006711",
"name": "calcium phosphate",
"pos": [
215,
232
]
} |
after 3 h of incubation with either 0.5 mm alanine or meaib , hepatic concentrations of these amino acids were significantly higher in the presence than absence of na+ ( 8 vs. 1 and 1 vs. 0.1 mm , respectively ) . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
43,
50
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
94,
105
]
} |
uptake of [ 3h ] alanine was inhibited by a 40-fold excess of serine and cysteine ( 53-54 % ) , by meaib and methylalanine ( 26-31 % ) , and by leucine ( 14 % ) , whereas d-alanine , beta-alanine , taurine , and glutamate had no effect . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
17,
24
]
} | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
183,
195
]
} |
the response of osteocalcin to the well-defined adrenal hormone system implies an important role for corticosteroids in the control of serum osteocalcin . | NA | {
"id": "C0019932",
"name": "hormone",
"pos": [
56,
63
]
} | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
101,
116
]
} |
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