text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
sulfate incorporation into glycosaminoglycans was measured and the glomerular heparan sulfate was isolated and biochemically characterized . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
27,
45
]
} | {
"id": "C0019143",
"name": "heparan",
"pos": [
78,
85
]
} |
fractional clearance of neutral dextrans was significantly increased in membranous nephropathy for dextrans greater than 48 a , while fractional clearance of dextran sulfates was significantly increased compared to controls for dextrans greater than 32 a . | NA | {
"id": "C0079224",
"name": "dextran sulfates",
"pos": [
158,
174
]
} | {
"id": "C0011806",
"name": "dextrans",
"pos": [
228,
236
]
} |
the sympathicoparalysis also explains the inflammation-free vascular fragility , with escape of cell elements , primarily protein ( albumins ) and lymphocytes ( verrey , matteucci , franceschetti and hermann , and francois ) into the aqueous and vitreous . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
122,
129
]
} | {
"id": "C0001924",
"name": "albumins",
"pos": [
132,
140
]
} |
baseline blood pressure , heart rate , adrenoceptor density , and plasma concentrations of epinephrine , norepinephrine , and cyclic adenosine monophosphate were normal . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
91,
102
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
105,
119
]
} |
we described two patients with severe thrombocytopenia and bleeding tendency related to treatment with glibenclamide ( short-acting sulfonylurea ) . | NA | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
103,
116
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
132,
144
]
} |
esophageal mucosal and muscularis blood flow ( q ) were measured in new zealand white rabbits treated intravenously with the prostaglandin analogs misoprostol ( pge1 ) , 16,16-dmpge2 ( pge2 ) , and iloprost ( pgi2 , prostacyclin ) . | NA | {
"id": "C0033568",
"name": "prostaglandin analogs",
"pos": [
125,
146
]
} | {
"id": "C0079594",
"name": "iloprost",
"pos": [
198,
206
]
} |
when germfree rats were exposed to bacterial endotoxin or bacteria via the gastrointestinal tract their kupffer cells increased in numbers to normal and the cells responded to lps in culture . | NA | {
"id": "C0014264",
"name": "bacterial endotoxin",
"pos": [
35,
54
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
176,
179
]
} |
to evaluate changes in phagocytosis , circulating pmns from normal rats were compared to circulating and alveolar pmns ( obtained by bronchoalveolar lavage , bal ) from rats after 72 hr of endotoxin infusion ( lps-rx ) -induced acute lung injury . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
189,
198
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
210,
213
]
} |
short-term cultured lak cells exhibited a strong to moderate degree of killing against normal intestinal fibroblasts , hapten-modified self cells , and four different tumor cell lines . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
105,
116
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
140,
145
]
} |
the guanosine triphosphate ( gtp ) ( 100 microm ) and 5'-guanylimido-di-phosphate [ gpp ( nh ) p ] ( 100 microm ) slightly creased [ 3h ] qnb binding and produced no or only a small ( factor 2-3 ) rightward shift of alinidine and aq-a 39 competition curves . | NA | {
"id": "C0018353",
"name": "guanosine triphosphate",
"pos": [
4,
26
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
84,
96
]
} |
natural ( n ) interleukin 1 ( il-1 ) and recombinant ( r ) il-1 alpha of murine p388d1 cell line origin were investigated for their antigenicity in rabbits . | NA | {
"id": "C0021755",
"name": "interleukin 1",
"pos": [
14,
27
]
} | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
59,
69
]
} |
addition of macrophage-colony-stimulating factor ( csf ) but not granulocyte/macrophage-csf , granulocyte-csf , or multi-csf reduced the lif-induced suppression of colony numbers and size . | NA | {
"id": "C0079784",
"name": "macrophage-colony-stimulating factor",
"pos": [
12,
48
]
} | {
"id": "C0009392",
"name": "csf",
"pos": [
121,
124
]
} |
estrogen replacement therapy is effective for the prevention and treatment of postmenopausal osteoporosis and should be offered to all women at high risk for osteoporosis . | NA | {
"id": "C0029458",
"name": "postmenopausal osteoporosis",
"pos": [
78,
105
]
} | {
"id": "C0029456",
"name": "osteoporosis",
"pos": [
158,
170
]
} |
these results indicate that the net negative surface charge of human diploid fibroblasts represents a cell surface maker for in vitro cellular age in the population . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
77,
88
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
134,
142
]
} |
a tissue-equivalent plastic/steel model , simulating the characteristics of a stainless steel , reconstructed mandible , was irradiated and measurements were made with a parallel plate ionization chamber . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
28,
33
]
} | {
"id": "C0038126",
"name": "stainless steel",
"pos": [
78,
93
]
} |
our studies also demonstrated that nmda increased lh via a direct effect on the hypothalamic release of lhrh since a potent lhrh antagonist competitively inhibited the effects of nmda . | NA | {
"id": "C0004015",
"name": "nmda",
"pos": [
35,
39
]
} | {
"id": "C0949755",
"name": "nmda",
"pos": [
179,
183
]
} |
the sensitivity to intracerebroventricular morphine-induced convulsions was determined in members of the severe seizure ( gepr-9 ) and moderate seizure ( gepr-3 ) colonies of genetically epilepsy-prone rats as well as in non-epileptic control rats . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
112,
119
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
187,
195
]
} |
the duration of the antigenic stimulation is a critical issue , but probably more important are the relevance and the purity of the allergen ( s ) . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
20,
29
]
} | {
"id": "C0002092",
"name": "allergen",
"pos": [
132,
140
]
} |
based on the following 3 points : 1 ) tumor proliferation is energy-dependent , 2 ) mitochondrial energy-production system is dominant for cell growth , and 3 ) liver mitochondria ( mt ) possess their own dna and rna synthesizing some of their own proteins including respiratory enzymes such as cytochrome oxidases , a possible relationship between mutations of mt-dna and clinical status of cell proliferation was examined in 10 hcc patients who underwent liver resection . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
205,
208
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
435,
436
]
} |
murine giardiasis and mucosal immunity : a model for the study of immunity to intestinal protozoan parasites . | NA | {
"id": "C0017536",
"name": "giardiasis",
"pos": [
7,
17
]
} | {
"id": "C0021832",
"name": "intestinal",
"pos": [
78,
88
]
} |
the measured frequency of correct rejoining of the damaged gene was found to vary both with the vector construct and with the recipient cell species ( chinese hamster v79 or human transformed fibroblasts ) . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
136,
140
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
192,
203
]
} |
using a sensitive in vitro enzymatic gene-amplification technique , we detected htlv-i sequences in fresh peripheral-blood mononuclear cells of all of 11 patients tested who were positive for the antibody , and in cell cultures of the spinal fluid from 3 of the 11 tested . | NA | {
"id": "C1321301",
"name": "peripheral-blood mononuclear cells",
"pos": [
106,
140
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
214,
218
]
} |
thus , the genetic defect in patients with scid affects not only the b-cell lineage but also the inducible expression of hla class ii genes that is normally observed in class ii-negative cells , such as fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
187,
192
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
203,
214
]
} |
insulin is produced from an inactive precursor , proinsulin , through initial endoproteolytic cleavage at sites marked by pairs of basic amino-acid residues . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
49,
59
]
} |
one ( type i ) cleaving exclusively on the c-terminal side of arg 31.arg 32 ( b-chain/c-peptide junction ) , the other ( type ii ) preferentially on the c-terminal side of lys 64.arg 65 of proinsulin ( c-peptide/a-chain junction ) . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
189,
199
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
202,
211
]
} |
the ca and ph requirements of these proteinases suggested that the type-ii proteinase would be active in the golgi apparatus and the secretory granule , whereas type-i activity would be compatible only with the intragranular environment . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
36,
47
]
} | {
"id": "C0030946",
"name": "proteinase",
"pos": [
75,
85
]
} |
the ability of tricyclic antidepressants , monoamine oxidase inhibitors , mianserin and ouabain to stimulate hydrolysis of inositol phosphates was examined in rat cerebral cortex slices using a direct assay which involves labelling with [ 3h ] inositol and assaying [ 3h ] inositol phosphates in the presence of lithium . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
123,
131
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
273,
292
]
} |
the interactions of eight piperidine derivatives with nicotinic receptor complexes from torpedo californica electric organ were studied using [ 125i ] alpha-bungarotoxin [ ( 125i ] bgt ) as a probe for the acetylcholine binding site and [ 3h ] perhydrohistrionicotoxin [ ( 3h ] h12-htx ) as a probe for a site associated with the receptor-gated ion channel . | NA | {
"id": "C0034830",
"name": "nicotinic receptor",
"pos": [
54,
72
]
} | {
"id": "C0034792",
"name": "acetylcholine binding site",
"pos": [
206,
232
]
} |
the hypothalamo-neurohypophysial system was investigated immunocytochemically using an antiserum against both neurophysins ( nps ) as primary antibody . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
87,
96
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
142,
150
]
} |
the serum levels of copper and ceruloplasmin were just below normal range , and the copper concentration in fibroblastic cells was much increased ( 101.2 ng/mg of protein ) . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
108,
120
]
} |
variables reviewed were mental status , neurological examination , presence or absence of loss of consciousness , clinical evidence of basilar skull fracture , and fracture on skull radiography . | NA | {
"id": "C0748830",
"name": "basilar skull fracture",
"pos": [
135,
157
]
} | {
"id": "C0037304",
"name": "fracture",
"pos": [
164,
172
]
} |
d-amphetamine , 5.0 mg/kg , was more effective than l-amphetamine , given at the same dose , in inducing these changes . | NA | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
0,
13
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
54,
65
]
} |
of the 23 patients , 11 had a generalized peripheral neuropathy , nine had multiple mononeuropathies , and three had a mononeuropathy . | NA | {
"id": "C0031117",
"name": "peripheral neuropathy",
"pos": [
42,
63
]
} | {
"id": "C0494491",
"name": "mononeuropathy",
"pos": [
119,
133
]
} |
we reviewed our experience with alpha coma , the finding of predominantly alpha-frequency rhythms in the eegs of unconscious patients , and identified 50 patients . | NA | {
"id": "C0009421",
"name": "coma",
"pos": [
38,
42
]
} | {
"id": "C0041657",
"name": "unconscious",
"pos": [
113,
124
]
} |
the most common type of peripheral neuropathy associated with human immunodeficiency virus ( hiv ) infection , predominantly sensory neuropathy , affects 10-30 % of patients with acquired immunodeficiency syndrome ( aids ) . | NA | {
"id": "C0019693",
"name": "human",
"pos": [
62,
67
]
} | {
"id": "C0001175",
"name": "acquired immunodeficiency syndrome",
"pos": [
179,
213
]
} |
a 44-year-old woman with livedo reticularis , multiple ischemic strokes , and transient ischemic attacks ( sneddon 's syndrome ) had antiphospholipid antibodies -- the lupus anticoagulant and anticardiolipin antibodies . | NA | {
"id": "C0162595",
"name": "antiphospholipid",
"pos": [
133,
149
]
} | {
"id": "C0085240",
"name": "lupus anticoagulant",
"pos": [
168,
187
]
} |
a 44-year-old woman with livedo reticularis , multiple ischemic strokes , and transient ischemic attacks ( sneddon 's syndrome ) had antiphospholipid antibodies -- the lupus anticoagulant and anticardiolipin antibodies . | NA | {
"id": "C0162595",
"name": "antiphospholipid",
"pos": [
133,
149
]
} | {
"id": "C0162596",
"name": "anticardiolipin antibodies",
"pos": [
192,
218
]
} |
in a double-blind cross-over trial , primidone was superior to both placebo and phenobarbital in reducing essential tremor in 13 patients . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
37,
46
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
80,
93
]
} |
phenobarbital , at a dosage yielding serum barbiturate levels greater than those seen with primidone , was not better than placebo . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
0,
13
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
43,
54
]
} |
thus , primidone has an effect in essential tremor independent from that of its metabolite phenobarbital . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
7,
16
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
91,
104
]
} |
it is concluded that l ( - ) -baclofen depresses gaba-mediated inhibitory postsynaptic potentials by a presynaptic action at gabab receptors on or near the terminals of the inhibitory neuron . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
30,
38
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
125,
129
]
} |
the precise topographical changes in striatal d1 and d2 dopamine receptor density that occurred after chronic treatment with haloperidol or sch 23390 or after 6-hydroxydopamine-induced lesion of the mesostriatal dopaminergic pathway have been studied autoradiographically in the rat . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
56,
64
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
212,
224
]
} |
low affinity [ 3h ] pcp-3-oh binding , which may represent a pcp-selective site , is not affected by gtp and gpp ( nh ) p . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
101,
104
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
109,
121
]
} |
under those conditions , [ 3h ] 5-ht labelled an apparently homogeneous population of 5-ht1-like sites which display nanomolar affinity for tryptamines ( 5-carboxamido-tryptamine , ( 5-ct ) greater than 5-ht greater than or equal to 5-methoxytryptamine ( 5-meot ) greater than tryptamine ) and some ergolines ( metergoline greater than methysergide ) . | NA | {
"id": "C0036751",
"name": "5-ht",
"pos": [
32,
36
]
} | {
"id": "C0000589",
"name": "methoxytryptamine",
"pos": [
235,
252
]
} |
under those conditions , [ 3h ] 5-ht labelled an apparently homogeneous population of 5-ht1-like sites which display nanomolar affinity for tryptamines ( 5-carboxamido-tryptamine , ( 5-ct ) greater than 5-ht greater than or equal to 5-methoxytryptamine ( 5-meot ) greater than tryptamine ) and some ergolines ( metergoline greater than methysergide ) . | NA | {
"id": "C0014699",
"name": "ergolines",
"pos": [
299,
308
]
} | {
"id": "C0025641",
"name": "metergoline",
"pos": [
311,
322
]
} |
under those conditions , [ 3h ] 5-ht labelled an apparently homogeneous population of 5-ht1-like sites which display nanomolar affinity for tryptamines ( 5-carboxamido-tryptamine , ( 5-ct ) greater than 5-ht greater than or equal to 5-methoxytryptamine ( 5-meot ) greater than tryptamine ) and some ergolines ( metergoline greater than methysergide ) . | NA | {
"id": "C0014699",
"name": "ergolines",
"pos": [
299,
308
]
} | {
"id": "C0025842",
"name": "methysergide",
"pos": [
336,
348
]
} |
our data support the usefulness of phaclofen as a competitive antagonist of baclofen , and suggest that when larger stimulus intensities are applied , the lhp in the dorsolateral septum of the rat may be mediated by a transmitter in addition to gamma-aminobutyric acid ( gaba ) . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
76,
84
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
271,
275
]
} |
this analogue had negligible ability to lower serum calcium relative to salmon calcitonin ( sct ) , however , the pattern of neuronal membrane sensitivity to cta was similar to that produced by sct and calcitonin generelated peptide . | NA | {
"id": "C0073994",
"name": "sct",
"pos": [
92,
95
]
} | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
202,
212
]
} |
single channel recordings were obtained from inside-out patches of cultured human neuroblastoma cells ( cell line sh-sy5y ) treated with a phorbol ester , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) to induce differentiation . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
139,
152
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
155,
191
]
} |
an important finding is that because of the high prevalence of gingivitis and plaque , these indicators were not related to radiographic evidence of periodontal disease . | NA | {
"id": "C0017574",
"name": "gingivitis",
"pos": [
63,
73
]
} | {
"id": "C0017563",
"name": "periodontal disease",
"pos": [
149,
168
]
} |
these antibodies allowed detection of a minimum of 50 , 44 , and 47 bands in immunoblots of cellular lysates from fibroblasts transformed by v-src , v-yes , or v-fps respectively . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
92,
100
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
114,
125
]
} |
s13 transformed erythroblasts and fibroblasts revert to a normal morphology in the presence of the alpha glucosidase-1 inhibitor castanospermine , whereas cells transformed by the v-src or v-erbb oncogenes are unaffected by this drug . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
34,
45
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
155,
160
]
} |
we have analysed the role of the cellular oncogene , c-myc in the process of in vitro cellular ageing and spontaneous cellular immortalization using rodent fibroblasts . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
33,
41
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
156,
167
]
} |
the substances studied were morphine , the pyrazolone derivatives , metamizol ( dipyrone ) and aminophenazone ( 'pyramidon ' ) , lysine acetylsalicylate , and paracetamol . | NA | {
"id": "C0012586",
"name": "dipyrone",
"pos": [
80,
88
]
} | {
"id": "C0002586",
"name": "pyramidon",
"pos": [
113,
122
]
} |
the ed50 of metamizol in depressing evoked activity in vdm neurones is 120 mg/kg , and that of aminophenazone is 22.7 mg/kg . | NA | {
"id": "C0012586",
"name": "metamizol",
"pos": [
12,
21
]
} | {
"id": "C0002586",
"name": "aminophenazone",
"pos": [
95,
109
]
} |
it has been found previously that metamizol increased nociceptive activity in some ascending axons and aminophenazone increased this activity in all ascending axons tested . | NA | {
"id": "C0012586",
"name": "metamizol",
"pos": [
34,
43
]
} | {
"id": "C0002586",
"name": "aminophenazone",
"pos": [
103,
117
]
} |
the metabolites of 5-hydroxytryptamine ( 5-ht , serotonin ) namely , l-tryptophan , 5-hydroxytryptophan , 5-hydroxyindole acetic acid and 5-hydroxytryptophol were measured in perfused tissue and whole worms from adult female ascaris suum using reversed-phase liquid chromatography with electrochemical detection . | NA | {
"id": "C0041249",
"name": "l-tryptophan",
"pos": [
69,
81
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
84,
103
]
} |
it is possible to define a standard karyotype and-by comparison-to bring to the fore chromosomes abnormalities ( translocation , deletion , polysomy ) . | NA | {
"id": "C0008626",
"name": "chromosomes",
"pos": [
85,
96
]
} | {
"id": "C0040715",
"name": "translocation",
"pos": [
113,
126
]
} |
activities were measured daily and isoenzyme patterns were determined on the day of maximal urinary enzyme excretion . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
35,
44
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
100,
106
]
} |
the ongoing discoveries of new beta-lactamases , mainly penicillinases , in gram-negative bacteria has emphasized the problem of their precise identification , and thus their phylogeny . | NA | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
31,
46
]
} | {
"id": "C0030841",
"name": "penicillinases",
"pos": [
56,
70
]
} |
charge calculations in molecular mechanics 6 : the calculation of partial atomic charges in nucleic acid bases and the electrostatic contribution to dna base pairing . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
92,
104
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
149,
152
]
} |
serum concentrations of cholesterol , hdl cholesterol , and estradiol were significantly reduced by the fifth month on the diet . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
24,
35
]
} | {
"id": "C0023822",
"name": "hdl",
"pos": [
38,
41
]
} |
we conclude that , under the influence of exercise or emotion , patients with intermittent preexcitation may be at risk for serious arrhythmias . | NA | {
"id": "C0032915",
"name": "preexcitation",
"pos": [
91,
104
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
132,
143
]
} |
the need always to consider gynecologic disease in any female patient presenting with a history of colicky lower abdominal pain or an acute abdomen is emphasized . | NA | {
"id": "C0000737",
"name": "abdominal pain",
"pos": [
113,
127
]
} | {
"id": "C0000727",
"name": "acute",
"pos": [
134,
139
]
} |
this biochemical analysis indicates that authentic pentapeptides met- and leu-enkephalin may account for a large part ( more than 90 % ) of the enkephalin-like immunoreactivity detected in the fetal spinal cord investigated . | NA | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
74,
88
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
144,
154
]
} |
among other non-hodgkin 's lymphomas the molecular mechanisms behind t ( 11 ; 14 ) and t ( 14 ; 18 ) in b-cell lymphomas and 14q11 rearrangements in t-cell lymphomas are starting to be unravelled . | NA | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
12,
26
]
} | {
"id": "C0079731",
"name": "b-cell",
"pos": [
104,
110
]
} |
among other non-hodgkin 's lymphomas the molecular mechanisms behind t ( 11 ; 14 ) and t ( 14 ; 18 ) in b-cell lymphomas and 14q11 rearrangements in t-cell lymphomas are starting to be unravelled . | NA | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
12,
26
]
} | {
"id": "C0079772",
"name": "t-cell lymphomas",
"pos": [
149,
165
]
} |
[ how does one develop an autoimmune disease ? probable pathogenic role of a membrane protein associated with systemic lupus erythematosus ] . | NA | {
"id": "C0004364",
"name": "autoimmune disease",
"pos": [
26,
44
]
} | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
110,
138
]
} |
due to the high specificity of monoclonal antibodies , however , different fixation regimes may need to be considered for various combinations of antigen and antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
31,
52
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
158,
166
]
} |
the purified antibody showed a sensitive reaction to the t. spiralis antigen , but not to any other heterologous parasite antigens so far examined . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
69,
76
]
} | {
"id": "C0003333",
"name": "heterologous",
"pos": [
100,
112
]
} |
in order to investigate the role of renal factors in affecting trypsinogen 1 metabolism and excretion in chronic pancreatic disease , serum immunoreactive trypsin ( irt ) , urinary irt , gamma-glutamyltransferase ( ggt ) , alpha-glucosidase ( agl ) and rnase outputs and the molecular size distribution of serum and urine irt were studied in 8 control subjects , 18 cases with pancreatic cancer , and 23 cases with chronic pancreatitis . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
77,
87
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
92,
101
]
} |
in the present study , we also tested the effect of cgrp on gastrin-releasing peptide ( grp ; 10 ( -9 ) m ) - or cholecystokinin ( cck-8 , 10 ( -9 ) m ) -stimulated release of insulin from isolated rat islets in vitro . | NA | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
113,
128
]
} | {
"id": "C0037167",
"name": "cck-8",
"pos": [
131,
136
]
} |
alignments demonstrate 68 % -78 % positional identity between isoenzymes within the same class , and 29 % -32 % between the enzymes of different classes . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
62,
72
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
124,
131
]
} |
glutathione transferases within a class are highly similar and may be regarded as true isoenzymes , while transferases of different classes appear to occupy an intermediate stage between isoenzymes and discrete enzymes . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
87,
97
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
211,
218
]
} |
a cdna that encodes what appears to be the inhibitory domain of the plasma membrane calcium-pumping atpase ( ca2+-atpase ) has been isolated by screening a lambda gt11 bovine brain cdna library with antibodies prepared against the human erythrocyte membrane ca2+-atpase . | NA | {
"id": "C0300252",
"name": "plasma",
"pos": [
68,
74
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
258,
261
]
} |
branched butanols ( 2-methyl-1-propanol and 2-methyl-2-propanol ) and ethanol ( to a lesser degree ) promote cholesterol aggregation , while methanol , acetone , and 1-butanol do not . | NA | {
"id": "C0001977",
"name": "butanols",
"pos": [
9,
17
]
} | {
"id": "C0076141",
"name": "2-methyl-2-propanol",
"pos": [
44,
63
]
} |
branched butanols ( 2-methyl-1-propanol and 2-methyl-2-propanol ) and ethanol ( to a lesser degree ) promote cholesterol aggregation , while methanol , acetone , and 1-butanol do not . | NA | {
"id": "C0001977",
"name": "butanols",
"pos": [
9,
17
]
} | {
"id": "C0089147",
"name": "1-butanol",
"pos": [
166,
175
]
} |
branched butanols ( 2-methyl-1-propanol and 2-methyl-2-propanol ) and ethanol ( to a lesser degree ) promote cholesterol aggregation , while methanol , acetone , and 1-butanol do not . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
70,
77
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
141,
149
]
} |
to understand the cellular changes associated with transformation of hepatocytes to the malignant state , we have made several libraries of monoclonal antibodies against the hepatocellular carcinoma cell line focus and have found six antibodies ( af-20 , sf-25 , sf-31 , sf-90 , xf-4 , and xf-8 ) that recognize antigens expressed at consistently higher levels on hepatoma cells . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
140,
150
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
234,
244
]
} |
hemolysates were found to catalyze efficient dephosphorylation of fdump to yield nearly stoichiometric amounts of the corresponding deoxyribonucleoside 5-fluoro-2'-deoxyuridine ( fdurd ) , an antineoplastic drug showing selective cytotoxicity toward liver metastases from colorectal carcinomas . | NA | {
"id": "C0011528",
"name": "deoxyribonucleoside",
"pos": [
132,
151
]
} | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
164,
176
]
} |
the enzyme responsible for the fdump-to-fdurd conversion was identified with the deoxyribonucleotide-specific isozyme of erythrocyte pyrimidine 5'-nucleotidase ( ec 3.1.3.5 ) . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
4,
10
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
110,
117
]
} |
both the survival and cellular content of marrow , including hemopoietic stem cells and granulocyte-macrophage progenitors , were reduced . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
22,
30
]
} | {
"id": "C0018956",
"name": "hemopoietic stem cells",
"pos": [
61,
83
]
} |
both the survival and cellular content of spleen , including hemopoietic stem cells and granulocyte-macrophage progenitors , were similar to those of the control group . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
22,
30
]
} | {
"id": "C0018956",
"name": "hemopoietic stem cells",
"pos": [
61,
83
]
} |
however , the differential expression of plc isozymes suggests further that certain neurotransmitter and receptor interactions may differ in the forms of the plc enzyme used for signal transduction . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
45,
53
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
162,
168
]
} |
several lines of evidence indicate that tachykinin neuropeptides [ substance p ( sp ) , substance k ( sk ) , and neuromedin k ( nk ) ] play a role in regulating the inflammatory and immune responses . | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
40,
50
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
67,
78
]
} |
several lines of evidence indicate that tachykinin neuropeptides [ substance p ( sp ) , substance k ( sk ) , and neuromedin k ( nk ) ] play a role in regulating the inflammatory and immune responses . | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
40,
50
]
} | {
"id": "C0038581",
"name": "substance k",
"pos": [
88,
99
]
} |
several lines of evidence indicate that tachykinin neuropeptides [ substance p ( sp ) , substance k ( sk ) , and neuromedin k ( nk ) ] play a role in regulating the inflammatory and immune responses . | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
40,
50
]
} | {
"id": "C0027847",
"name": "neuromedin k",
"pos": [
113,
125
]
} |
twenty-four hours after insulin injection , levels of mrnas encoding neuropeptides ( enkephalin and neuropeptide y ) were increased 6.5-fold , whereas those of mrnas for the major secretory proteins ( chromogranins a and b ) were unchanged . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
69,
82
]
} | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
100,
114
]
} |
in injected oocytes n-me-d-asp application ( with glycine ) evoked a partially desentizing inward current that was potentiated by glycine and blocked by d- ( - ) -amino-5-phosphonovaleric acid ( d-apv ) , by zn2+ and , in a voltage-dependent manner , by mg2+ . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
50,
57
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
163,
168
]
} |
at hyposmotic concentrations of nacl the epithelial responses include inward sodium and outward chloride components . | NA | {
"id": "C0037494",
"name": "nacl",
"pos": [
32,
36
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
96,
104
]
} |
in order to assess a possible action of prostaglandins and radiation on dopaminergic activity , the functioning of striatal dopaminergic autoreceptors was examined by determining the effects of varying concentrations of haloperidol on the k+-evoked release of dopamine from striatal slices obtained from parallel groups of animals treated as above . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
72,
84
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
260,
268
]
} |
although the dihydropyridine ( dhp ) calcium channel antagonist nifedipine inhibited all aspects of the syndrome , lateral head dyskinesias ( laterocollis ) and circling abnormalities were the most significantly affected signs . | NA | {
"id": "C2945601",
"name": "dihydropyridine",
"pos": [
13,
28
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
64,
74
]
} |
effects of the adenosine analogs r-n6-phenylisopropyl-adenosine ( r-pia ) and 5'-n-ethylcarboxamidoadenosine ( neca ) , alone and in combination with caffeine , were studied in squirrel monkeys trained to respond under multiple fixed-interval fixed-ratio schedules of reinforcement . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
15,
24
]
} | {
"id": "C0050789",
"name": "5",
"pos": [
78,
79
]
} |
neca was about ten times more potent than r-pia in producing these effects , the order of potency suggests that these effects may be mediated by actions at a2-adenosine receptors . | NA | {
"id": "C0050789",
"name": "neca",
"pos": [
0,
4
]
} | {
"id": "C0001443",
"name": "r-pia",
"pos": [
42,
47
]
} |
low doses of apomorphine act on the dopamine receptors on the dopaminergic terminals themselves to inhibit the release of endogenous dopamine . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
62,
74
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
133,
141
]
} |
a behavioral difference between the sexes was thus observed when post-synaptic dopamine receptors were blocked by a dopamine antagonist , but not when dopaminergic stimulation of post-synaptic dopamine receptors was reduced by pre-synaptic inhibition of dopamine release . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
151,
163
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
254,
262
]
} |
accumulation of 3h-etorphine or 3h-ethylketocyclazocine , a putative ligand for the kappa receptor subtype , was not increased in the hypothalamus of the tbr , as might have been expected if there were less endogenous dynorphin to occupy the opioid receptors in this region . | NA | {
"id": "C0064239",
"name": "kappa receptor",
"pos": [
84,
98
]
} | {
"id": "C0034801",
"name": "opioid receptors",
"pos": [
242,
258
]
} |
the effects of morphine , fentanyl , sufentanil and droperidol on motor coordination in mice were studied . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
26,
34
]
} | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
37,
47
]
} |
administration of analgesic doses of the mu agonists morphine , fentanyl and sufentanil did not inhibit motor coordination . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
64,
72
]
} | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
77,
87
]
} |
consistent with previous reports , typical barbiturates ( pentobarbital , secobarbital , phenobarbital ) produced dose-dependent increases in the number of shocks received at doses which did not depress background responding ( water intake ) . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
43,
55
]
} | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
58,
71
]
} |
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