text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
thus , small fibrin polymers , but not desaa-fibrin monomers , act as optimal substrates for the release of fpb by thrombin . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
13,
19
]
} | {
"id": "C0016023",
"name": "fpb",
"pos": [
108,
111
]
} |
the action of caffeine in a10 was completely blocked by pretreatment with the adenosine agonist l-phenyl-isopropyl-adenosine ( l-pia ) , confirming numerous lines of evidence that caffeine and other xanthines act as competitive antagonists at adenosine receptors . | NA | {
"id": "C0006644",
"name": "caffeine",
"pos": [
14,
22
]
} | {
"id": "C0043318",
"name": "xanthines",
"pos": [
199,
208
]
} |
both colchicine and the cytochalasins increased granulosa cell production of progesterone and of 20 alpha-hydroxy-pregn-4-en-3-one ( 20 alpha-oh-progesterone ) in a dose-dependent manner . | NA | {
"id": "C0012311",
"name": "20 alpha-hydroxy-pregn-4-en-3-one",
"pos": [
97,
130
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
145,
157
]
} |
in female rats , prl was measured during different physiological states : estrus , diestrus , proestrus at 1000 , 1200 , and 1600 h and days 1 and 21 of gestation and 2 days postpartum . | NA | {
"id": "C2916830",
"name": "physiological states",
"pos": [
51,
71
]
} | {
"id": "C0032961",
"name": "gestation",
"pos": [
153,
162
]
} |
plasma gonadotropin concentrations as well as pituitary content of the gonadotropins and prolactin were assessed at each of these time intervals . | NA | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
7,
19
]
} | {
"id": "C0018066",
"name": "pituitary",
"pos": [
46,
55
]
} |
plasma gonadotropin concentrations as well as pituitary content of the gonadotropins and prolactin were assessed at each of these time intervals . | NA | {
"id": "C0018066",
"name": "pituitary",
"pos": [
46,
55
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
89,
98
]
} |
pituitary gonadotropin and prolactin content were unaffected by thymectomy of the females , except at 90 days when pituitary luteinizing hormone ( lh ) content was lower in thymectomized than in control animals . | NA | {
"id": "C0018066",
"name": "pituitary gonadotropin",
"pos": [
0,
22
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
27,
36
]
} |
pituitary gonadotropin and prolactin content were unaffected by thymectomy of the females , except at 90 days when pituitary luteinizing hormone ( lh ) content was lower in thymectomized than in control animals . | NA | {
"id": "C0018066",
"name": "pituitary gonadotropin",
"pos": [
0,
22
]
} | {
"id": "C0023607",
"name": "pituitary luteinizing hormone",
"pos": [
115,
144
]
} |
high-intensity , prostaglandin-characteristic daughter fragments will allow a reliable quantification of prostaglandins in biological fluids and a reduction of sample clean-up . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
17,
30
]
} | {
"id": "C0033555",
"name": "a",
"pos": [
170,
171
]
} |
the methodology is based upon the formation of the pentafluorobenzyl ester of arachidonic acid , which is efficiently ionized using electron capture negative ion chemical ionization conditions to yield an abundant carboxylate anion at m/z 301 . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
40,
43
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
226,
231
]
} |
identifications of n-oxide and hydrolytic metabolites of the pyrrolizidine alkaloids senecionine and monocrotaline in extracts of mouse hepatic microsomal incubations were accomplished by comparing collisionally activated decomposition/mass-analyzed ion kinetic energy spectra of specific ions from microsomal extracts with spectra obtained from synthetic standards of suspected metabolites . | NA | {
"id": "C0034335",
"name": "pyrrolizidine alkaloids",
"pos": [
61,
84
]
} | {
"id": "C0085241",
"name": "monocrotaline",
"pos": [
101,
114
]
} |
histochemical examination of multisystemic lipid storage myopathy skin fibroblasts showed a massive accumulation of neutral lipids ( stained by the fluorescent probe nile red ) in cells grown in medium supplemented with 10 % fetal calf serum . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
71,
82
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
180,
185
]
} |
the language disorder corresponded in all patients to a severe form of amnesic aphasia but a moderate to marked semantic breakdown was also found . | NA | {
"id": "C0023015",
"name": "language disorder",
"pos": [
4,
21
]
} | {
"id": "C0003113",
"name": "amnesic aphasia",
"pos": [
71,
86
]
} |
the present investigation was undertaken to determine if an interaction affecting 45ca release from prelabeled fetal rat long bones could be elicited by the ca2+ ionophore , a-23187 , and the phorbol ester , 12-myristate 13-acetate ( pma ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
192,
205
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
234,
237
]
} |
calcium induced a concentration dependent increase in df/dt in normal and diabetic hearts , but in diabetes the dose-response curve to calcium chloride was shifted to the left . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
0,
7
]
} | {
"id": "C0006686",
"name": "calcium chloride",
"pos": [
135,
151
]
} |
malignant fibrous histiocytoma was the most frequent histologic type , followed by leiomyosarcoma , neurosarcoma , and fibrosarcoma . | NA | {
"id": "C0206729",
"name": "neurosarcoma",
"pos": [
100,
112
]
} | {
"id": "C0016057",
"name": "fibrosarcoma",
"pos": [
119,
131
]
} |
only one study has been found that describes the incidence of agglutination of erythrocytes from cancer patients using a monoclonal antibody , which detected an epitope on the rbc from cancer patients and was considered to be distinct from the antigen bound by naturally occurring anti-t . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
161,
168
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
244,
251
]
} |
in a multicenter study by the groupe francais de cytogenetique hematologique , chromosome investigation was undertaken in 55 cases of acutely transformed philadelphia-negative chronic myeloproliferative syndromes ( polycythemia vera , 34 cases ; essential thrombocythemia , two cases ; myelofibrosis with myeloid metaplasia of the spleen , 12 cases ; other , unclassified myeloproliferative disorders , seven cases ) . | NA | {
"id": "C0001815",
"name": "myelofibrosis with myeloid",
"pos": [
286,
312
]
} | {
"id": "C0027022",
"name": "myeloproliferative",
"pos": [
372,
390
]
} |
the histological diagnoses represented were squamous cell carcinoma ( n = 20 ) , adenocarcinoma ( n = 7 ) , small cell carcinoma ( n = 4 ) , mixed cell carcinoma ( n = 2 ) , bronchioloalveolar cell carcinoma ( n = 2 ) , large cell undifferentiated carcinoma ( n = 3 ) , bronchial carcinoid ( n = 1 ) , and metastatic tumors ( n = 3 ) . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
81,
95
]
} | {
"id": "C0007120",
"name": "bronchioloalveolar cell carcinoma",
"pos": [
174,
207
]
} |
during attempts to make antibodies cross-reactive with human lymphocytes , we established a monoclonal antibody ( vj-41 ) from the alloimmunization of mice , that is , b10.a ( 3r ) anti-b10.a ( 5r ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
24,
34
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
92,
111
]
} |
this suggests that these antigens are glycoproteins with o-linked oligosaccharides containing sialic acid in the epitope . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
25,
33
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
113,
120
]
} |
neither iic1c1 nor iic1m4 abolished bioactivity of recombinant mouse il-1 alpha , human il-1 , mouse , rat , or human il-2 , mouse il-3 , or colony-stimulating factor . | NA | {
"id": "C0021757",
"name": "il-3",
"pos": [
131,
135
]
} | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
141,
166
]
} |
while both otc and 2-me augmented the total intracellular glutathione concentration , pma enhanced only the level of oxidized glutathione . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
58,
69
]
} | {
"id": "C0061516",
"name": "oxidized",
"pos": [
117,
125
]
} |
the production of antibodies to nucleic acids , and in particular to dna , has been implicated in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus ( sle ) . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
32,
45
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
69,
72
]
} |
the production of antibodies to nucleic acids , and in particular to dna , has been implicated in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus ( sle ) . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
118,
137
]
} | {
"id": "C0024141",
"name": "systemic",
"pos": [
146,
154
]
} |
both menadione and 2,3-diome-1,4-nq caused an extensive gsh depletion accompanied by gssg formation , preceding loss of viability . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
56,
59
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
85,
89
]
} |
the final product was characterized by elemental analyses , phosphono phosphorus determinations , thin-layer chromatography and ir spectroscopy . | NA | {
"id": "C0013879",
"name": "elemental",
"pos": [
39,
48
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
70,
80
]
} |
the findings of these studies were as follows : ( i ) precipitation of calcium deoxycholate from mixtures of calcium chloride and monomeric deoxycholate ( at concentrations below the critical micelle concentration ( cmc ] is very slow even at relatively high cacl2 concentrations ( more than 20 days at 50 mm cacl2 ) . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
71,
78
]
} | {
"id": "C0006686",
"name": "calcium",
"pos": [
109,
116
]
} |
by 32p-postlabeling , although the active metabolite of apap formed dna adducts when incubated with isolated dna , no dna adduct formation was detected in the liver of rats either fed 0.1-1.5 % apap for 1 week or given 1 g/kg by gastric intubation . | NA | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
68,
79
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
118,
121
]
} |
hyperplasiogenic and tumor-promoting phorbol esters such as 12-o-tetradecanoylphorbol-13-acetate or 12-o-retinoylphorbol-13-acetate induce the sequential transient expression of the proto-oncogenes c-fos and c-myc and the ornithine decarboxylase gene in mouse skin in vivo . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
37,
51
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
60,
96
]
} |
history analysis for atopic symptoms , and serum ige levels , showed no differences between controls and ibd patients , or ibd subgroups ( crohn 's disease , ulcerative colitis , ulcerative proctitis ) . | NA | {
"id": "C0021390",
"name": "ibd",
"pos": [
105,
108
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
139,
155
]
} |
although concentrations of both noradrenalin and adrenalin in patients with mitral valve disease and dilated cardiomyopathy at rest were much higher than those without cardiovascular disease , only noradrenalin had a highly positive correlation with anp concentrations ( r = 0.88 p less than 0.001 , r = 0.78 p less than 0.001 , respectively ) . | NA | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
35,
44
]
} | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
198,
210
]
} |
difficulty in fully defining the injury , patient characteristics , osteoporosis , technically difficult surgery , the need for carefully supervised physiotherapy , and the realization that a poor initial result is very difficult to reconstruct make the comminuted fracture of the proximal humerus a problem fracture . | NA | {
"id": "C0476171",
"name": "comminuted",
"pos": [
254,
264
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
308,
316
]
} |
difficulty in fully defining the injury , patient characteristics , osteoporosis , technically difficult surgery , the need for carefully supervised physiotherapy , and the realization that a poor initial result is very difficult to reconstruct make the comminuted fracture of the proximal humerus a problem fracture . | NA | {
"id": "C0037006",
"name": "fracture of",
"pos": [
265,
276
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
308,
316
]
} |
famotidine , an h2-receptor antagonist with a thiazole nucleus , is approximately 7.5 times more potent than ranitidine and 20 times more potent than cimetidine on an equimolar basis . | NA | {
"id": "C0015620",
"name": "famotidine",
"pos": [
0,
10
]
} | {
"id": "C0039859",
"name": "thiazole",
"pos": [
46,
54
]
} |
this probably arises from the difference in responses of the thromboplastins to depression of vitamin k-dependent clotting factors . | NA | {
"id": "C0040048",
"name": "thromboplastins",
"pos": [
61,
76
]
} | {
"id": "C0005789",
"name": "clotting",
"pos": [
114,
122
]
} |
ai-cah is heterogeneous , and at least three different subgroups of ai-cah can be distinguished by circulating autoantibodies including antinuclear antibodies ( ana ) , liver membrane autoantibodies ( lma ) , liver kidney microsomal antibodies ( lkm ) , and antibodies to a soluble liver antigen ( sla ) . | NA | {
"id": "C0003243",
"name": "antinuclear antibodies",
"pos": [
136,
158
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
184,
198
]
} |
antibodies against many microorganisms and autoantibodies to mucosal components are commonly found in these patients . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
43,
57
]
} |
we examined the effects of dna : anti-dna immune complexes , formed at different antigen : antibody ratios , on the ability of t cells to modulate dna antibody production in vitro . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
42,
58
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
151,
159
]
} |
clinically , otologic disease can occur in association with a wide variety of systemic autoimmune and immunologic disorders : systemic lupus erythematosus , rheumatoid arthritis , behcet 's disease , sjogren 's syndrome , relapsing polychondritis , ulcerative colitis , cogan 's syndrome , and vasculitis-related disease . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
157,
177
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
200,
219
]
} |
the accumulation of free l-tryptophan and glycine in the small intestine of chicks , as well as of amino acids released at the hydrolysis of glycyl-l-tryptophan , glycyl-l-leucine and glycyl-l-valine , was studied under experiments in vitro with accumulating preparations of chicks intestinal mucosa . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
42,
49
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
99,
110
]
} |
skin ulceration appeared to be a more specific sign for occupational dermatosis in chrome platers than dermatitis when the prevalence rates were compared to controls . | NA | {
"id": "C0037299",
"name": "skin ulceration",
"pos": [
0,
15
]
} | {
"id": "C0037274",
"name": "dermatosis",
"pos": [
69,
79
]
} |
analysis of alkaline borohydride-released glycosaminoglycan chains by sepharose cl-6b , sephadex g-25 , and thin layer chromatography demonstrated a mixture of three proteoglycan families composed of chondroitin sulfate , dermatan sulfate , and heparan sulfate glycosaminoglycans . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
245,
260
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
261,
279
]
} |
the classic teaching is that ticks are best removed with nail polish , solvents , petrolatum , mineral oil , or a hot match . | NA | {
"id": "C0031262",
"name": "petrolatum",
"pos": [
82,
92
]
} | {
"id": "C0026156",
"name": "mineral oil",
"pos": [
95,
106
]
} |
in 12 patients with empty iron stores the effects of ferrous sulfate ( 80 mg fe++ ) three times daily for six weeks were studied . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
26,
30
]
} | {
"id": "C0060282",
"name": "ferrous sulfate",
"pos": [
53,
68
]
} |
gaba mimetics such as baclofen , aminooxyacetic acid ( aoaa ) and diazepam decreased naloxone-precipitated abstinence wet dog shakes in morphine dependent rats . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
0,
4
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
22,
30
]
} |
initially massive doses of adrenaline and noradrenaline , and their continued administration over the subsequent 26 hours , succeeded in normalizing the blood pressure and after transitory pacing , terminated , the arrhythmia in the course of 24 hours . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
27,
37
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
42,
55
]
} |
the satellite dna sequences located near the centromeric regions of mouse chromosomes replicate very late in s in both fibroblast and lymphocyte cells and are heavily methylated at cpg residues . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
119,
129
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
145,
150
]
} |
rop protects the stems of rnai and rnaii from digestion by rnases while the sensitivity of the loops to digestion by rnase t1 is not affected by high concentrations of rop . | NA | {
"id": "C0014241",
"name": "rnases",
"pos": [
59,
65
]
} | {
"id": "C0018364",
"name": "rnase t1",
"pos": [
117,
125
]
} |
the distributions of ankyrin , spectrin , band 3 , and glycophorin a were examined in plasmodium falciparum-infected erythrocytes by immunoelectron microscopy to determine whether movement of parasite proteins and membrane vesicles between the parasitophorous vacuole membrane and erythrocyte surface membrane involves internalization of host membrane skeleton proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
201,
209
]
} | {
"id": "C0025252",
"name": "membrane",
"pos": [
343,
351
]
} |
these three antibodies as well as the monoclonal antibody to glycophorin a bound to the membrane skeleton of infected and uninfected erythrocytes . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
12,
22
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
38,
57
]
} |
by immunocytochemistry , metabolic labeling and enzyme assay , the arylsulfatase a in i-cell fibroblasts was shown to be synthesized , stored and secreted at a level that was several-fold higher than that present in heterozygous i-cell or normal fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
88,
92
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
246,
257
]
} |
arylsulfatase a in i-cell fibroblasts differed from arylsulfatase in normal fibroblasts by the absence of endoglycosidase h-sensitive phosphorylated oligosaccharides . | NA | {
"id": "C0007804",
"name": "arylsulfatase a",
"pos": [
0,
15
]
} | {
"id": "C0003940",
"name": "arylsulfatase",
"pos": [
52,
65
]
} |
in the present case , the initial observation was of hyperphenylalaninaemia with a significant increase in the neopterin to biopterin ratio in the urine . | NA | {
"id": "C0068527",
"name": "neopterin",
"pos": [
111,
120
]
} | {
"id": "C0005562",
"name": "biopterin",
"pos": [
124,
133
]
} |
the acrocallosal syndrome is characterized by peculiar facies , polydactyly of the hands and/or feet , and agenesis of the corpus callosum . | NA | {
"id": "C0796147",
"name": "acrocallosal syndrome",
"pos": [
4,
25
]
} | {
"id": "C0175754",
"name": "agenesis of the corpus callosum",
"pos": [
107,
138
]
} |
however , studies in unmedicated patients with different types of seizures are needed to further clarify the possible role of somatostatin in human epilepsy . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
66,
74
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
148,
156
]
} |
the levels of other acute-phase protein ( hpt , trf , a alpha g , alpha mg , crp , alb ) and immunoglobulins ( igg , igm , iga ) were similar in ad patients and normal controls . | NA | {
"id": "C0001347",
"name": "acute-phase protein",
"pos": [
20,
39
]
} | {
"id": "C0018595",
"name": "hpt",
"pos": [
42,
45
]
} |
the levels of other acute-phase protein ( hpt , trf , a alpha g , alpha mg , crp , alb ) and immunoglobulins ( igg , igm , iga ) were similar in ad patients and normal controls . | NA | {
"id": "C0001347",
"name": "acute-phase protein",
"pos": [
20,
39
]
} | {
"id": "C0040679",
"name": "trf",
"pos": [
48,
51
]
} |
the levels of other acute-phase protein ( hpt , trf , a alpha g , alpha mg , crp , alb ) and immunoglobulins ( igg , igm , iga ) were similar in ad patients and normal controls . | NA | {
"id": "C0001347",
"name": "acute-phase protein",
"pos": [
20,
39
]
} | {
"id": "C0029297",
"name": "a alpha g",
"pos": [
54,
63
]
} |
the levels of other acute-phase protein ( hpt , trf , a alpha g , alpha mg , crp , alb ) and immunoglobulins ( igg , igm , iga ) were similar in ad patients and normal controls . | NA | {
"id": "C0001347",
"name": "acute-phase protein",
"pos": [
20,
39
]
} | {
"id": "C0006560",
"name": "crp",
"pos": [
77,
80
]
} |
altogether , 24 patients from the initial cohort were subsequently operated on for primary hpt but there were only two further cases of verified hpt , which developed during the follow-up period , in those who had been clearly normocalcaemic at the health surveys . | NA | {
"id": "C0221002",
"name": "primary hpt",
"pos": [
83,
94
]
} | {
"id": "C0020502",
"name": "hpt",
"pos": [
145,
148
]
} |
we , therefore , studied the effects of lactulose ( a non-absorbable disaccharide ) , which is capable of acidifying colonic contents , on secondary bile acid metabolism . | NA | {
"id": "C0022957",
"name": "lactulose",
"pos": [
40,
49
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
69,
81
]
} |
hyperlactataemia , hyperkalemia and heart block in acute iron overload : the fatal role of the hepatic iron-incorporation rate in rats on ferric citrate infusions . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
57,
61
]
} | {
"id": "C0060231",
"name": "ferric citrate",
"pos": [
138,
152
]
} |
an animal model is presented that provides constant and controllable conditions for approaching gradually , and within reasonable time , different stages of iron overload and , probably , an iron-induced mitochondrial disorder . | NA | {
"id": "C0282193",
"name": "iron",
"pos": [
157,
161
]
} | {
"id": "C0012715",
"name": "iron",
"pos": [
191,
195
]
} |
these observations are consistent with conversion of prekallikrein to kallikrein by factor xii , and with evidence that kallikrein proteolysis in vitro is activated in the cold by alteration of its binding to c-i esterase inhibitor . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
53,
66
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
120,
130
]
} |
these findings are in agreement with the concept that the interaction of fibroblasts with 'immunocompetent cells ' is crucial in the initial activation of connective tissue metabolism in fibrosis . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
73,
84
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
107,
112
]
} |
plasma drug and antiplatelet profiles of the original acetylsalicylic acid preparations used in the amis , paris and german-austrian trials for secondary prevention of myocardial infarction . | NA | {
"id": "C0004057",
"name": "amis",
"pos": [
100,
104
]
} | {
"id": "C0732279",
"name": "paris",
"pos": [
107,
112
]
} |
in a cross-over study 6 healthy male subjects were given for 9 days the acetylsalicylic acid ( asa ) preparations used in the aspirin myocardial infarction study ( amis ) , persantine-aspirin reinfarction study ( paris ) and german-austrian secondary heart attack prevention trials , exactly according to the original study protocols . | NA | {
"id": "C0004057",
"name": "aspirin",
"pos": [
126,
133
]
} | {
"id": "C0732279",
"name": "persantine-aspirin",
"pos": [
173,
191
]
} |
cutaneous blood flow was measured continuously with a laser doppler flowmeter , and noradrenaline and adrenaline concentrations were determined in blood samples drawn every 15 min . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
84,
97
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
102,
112
]
} |
the effect of systemic infection with various isolates of lymphocytic choriomeningitis virus ( lcmv ) on the capacity of mice to mount a t cell-independent igm and a t cell-dependent igg neutralizing antibody response against a subsequent infection with vesicular stomatitis virus ( vsv ) was analyzed . | NA | {
"id": "C0243026",
"name": "systemic infection",
"pos": [
14,
32
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
239,
248
]
} |
t cell epitopes in experimental autoimmune myasthenia gravis of the rat : strain-specific epitopes and cross-reaction between two distinct segments of the alpha chain of the nicotinic acetylcholine receptor ( torpedo californica ) . | NA | {
"id": "C0282580",
"name": "t cell epitopes",
"pos": [
0,
15
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
90,
98
]
} |
ontogeny of human complement receptors cr1 and cr3 : expression of these molecules on monocytes and neutrophils from maternal , newborn and fetal samples . | NA | {
"id": "C0034793",
"name": "complement receptors",
"pos": [
18,
38
]
} | {
"id": "C0079785",
"name": "cr3",
"pos": [
47,
50
]
} |
chemotactic factors such as formyl-methionyl-leucyl-phenylalanine or leukotriene b4 induced an increase of the expression of cr1 and cr3 which was more pronounced on cells from maternal and cord samples than from nonpregnant adult controls . | NA | {
"id": "C0008013",
"name": "chemotactic factors",
"pos": [
0,
19
]
} | {
"id": "C0027229",
"name": "formyl-methionyl-leucyl-phenylalanine",
"pos": [
28,
65
]
} |
this purification procedure allowed a complete separation of interleukin 2 and interleukin 4 activities from bcaf . | NA | {
"id": "C0021764",
"name": "interleukin",
"pos": [
61,
72
]
} | {
"id": "C0021758",
"name": "bcaf",
"pos": [
109,
113
]
} |
in unstimulated pbmc cultures the percentage of iga receptor-positive cells slightly increased at 48 h and was more elevated after 7 days . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
16,
20
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
30,
33
]
} |
furthermore , pha or con a stimulation of b cell-depleted pbmc suspensions resulted in a marked increase of cells bearing receptors for iga . | NA | {
"id": "C1321301",
"name": "cell",
"pos": [
44,
48
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
108,
113
]
} |
all of the 50 strains were highly sensitive to penicillin , methylphenylisoxazolyl penicillin , erythromycin , spiramycin , lincomycin , chloramphenicol , tetracycline , kanamycin , gentamicin and cephaloridine , but were resistant to sulfisoxazole . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
47,
57
]
} | {
"id": "C0029983",
"name": "methylphenylisoxazolyl penicillin",
"pos": [
60,
93
]
} |
prognostic relevance of serum-markers in relation to histopathology , stage and initial symptoms in advanced low-grade non-hodgkin lymphomas . | NA | {
"id": "C0079747",
"name": "low-grade",
"pos": [
109,
118
]
} | {
"id": "C0024305",
"name": "non-hodgkin",
"pos": [
119,
130
]
} |
the prognostic relevance of 4 different serum markers ( deoxythymidine kinase = s-tk , lactic dehydrogenase = s-ldh , s-haptoglobin and s-orosomucoid ) in relation to histopathology according to the kiel classification , stage and presence or absence of initial symptoms were investigated in 168 consecutive cases of low-grade non-hodgkin lymphomas ( nhl ) . | NA | {
"id": "C0079747",
"name": "low-grade",
"pos": [
317,
326
]
} | {
"id": "C0024305",
"name": "non-hodgkin",
"pos": [
327,
338
]
} |
20 patients with aplastic anaemia were treated with methylprednisolone 1 g/d for 3 d followed by prednisolone 60 mg on alternate days . | NA | {
"id": "C0025815",
"name": "methylprednisolone",
"pos": [
52,
70
]
} | {
"id": "C0032950",
"name": "60",
"pos": [
110,
112
]
} |
our data can be explained by the existence of several alleles of a genetic factor closely linked to the beta globin gene cluster and involved in the determination of g gamma to a gamma globin ratio . | NA | {
"id": "C0005221",
"name": "beta",
"pos": [
104,
108
]
} | {
"id": "C0017033",
"name": "gamma",
"pos": [
179,
184
]
} |
the structural parameters ( rg , rc , semi-axes ) have been determined for free phenylalanyl-trna synthetase and trnaphe from e. coli mre-600 and of enzyme complexes possessing one and two trnaphe molecules , indicating structural rearrangements of the enzyme in the interaction with trnaphe . | NA | {
"id": "C0026741",
"name": "enzyme complexes",
"pos": [
149,
165
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
253,
259
]
} |
residues beta glu-181 and beta glu-192 of e. coli f1-atpase ( the dccd-reactive residues ) were mutated to gln . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
14,
17
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
107,
110
]
} |
rank order of binding activities was : gtp gamma s greater than gtp greater than 8-n3-gtp ; | NA | {
"id": "C0079469",
"name": "gtp",
"pos": [
39,
42
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
86,
89
]
} |
the binding of gtp gamma s and gtp , but not of 8-n3-gtp , was stimulated by receptor agonists . | NA | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
15,
26
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
53,
56
]
} |
pretreatment of d. discoideum cells with pertussis toxin did not affect basal gtp and gtp gamma s binding , but eliminated the camp stimulation of gtp and gtp gamma s binding . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
78,
81
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
155,
166
]
} |
hydroxyproline ( hyp ) analogues of bradykinin and lysyl-bradykinin , in which the third residue of bradykinin , proline , is replaced by hydroxyproline , were isolated from human urine . | NA | {
"id": "C0022474",
"name": "lysyl-bradykinin",
"pos": [
51,
67
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
100,
110
]
} |
hydroxyproline ( hyp ) analogues of bradykinin and lysyl-bradykinin , in which the third residue of bradykinin , proline , is replaced by hydroxyproline , were isolated from human urine . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
7,
14
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
138,
152
]
} |
in reconstitution experiments of active 60 s subunits from inactive core particles obtained by using dimethyl maleic anhydride ( dmma ) , we observed that the phosphoproteins p1-p2 were extracted from the subunit by dmma as a complex with other proteins . | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
159,
174
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
245,
253
]
} |
clotting factors from a. acutus venom released only fibrinopeptide a from the a alpha chain of fibrinogen , while thrombin released fibrinopeptide a and b from the a alpha and b beta chains . | NA | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
0,
16
]
} | {
"id": "C0040018",
"name": "thrombin",
"pos": [
114,
122
]
} |
cf-1 ( c ) and cf-2 ( t ) , like thrombin , rapidly activated factor xiii in the presence of calcium ions , whereas cf-2 ( c ) and cf-1 ( t ) had little effect on factor xiii . | NA | {
"id": "C0015533",
"name": "activated factor xiii",
"pos": [
52,
73
]
} | {
"id": "C0015528",
"name": "factor xiii",
"pos": [
163,
174
]
} |
our results suggest that : 1 ) the operative risk of liver resection in cirrhosis is low , provided preventive measures are taken to avoid intraoperative bleeding and postoperative variceal bleeding and ascites , and 2 ) late survival is good in selected groups of patients after resection of hepatocellular carcinoma and cirrhosis . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
154,
162
]
} | {
"id": "C0032788",
"name": "postoperative",
"pos": [
167,
180
]
} |
5 beta-pregnane-3 alpha,6 alpha,17 alpha,20 beta-tetrol and 5 beta-pregnane-3 alpha,6 alpha,17 alpha-triol-20-one : steroids of ovarian origin in the african catfish , clarias gariepinus , during oocyte maturation . | NA | {
"id": "C0033006",
"name": "pregnane",
"pos": [
7,
15
]
} | {
"id": "C0038317",
"name": "steroids",
"pos": [
116,
124
]
} |
the in vitro enzyme activities of sen1-1 and sen2-1 complement in extracts from a heterozygous diploid , but fail to complement in mixed extracts from separate sen1-1 and sen2-1 haploid strains . | NA | {
"id": "C0009499",
"name": "1 complement",
"pos": [
50,
62
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
117,
127
]
} |
evaluated individually , 44 % of the genetic markers ( including some markers on 11 of 15 chromosomes with any markers typed ) were found to be significantly correlated with survival ( p less than 0.05 ) although one would only expect 5 % of the markers to be significant by chance . | NA | {
"id": "C0017393",
"name": "genetic markers",
"pos": [
37,
52
]
} | {
"id": "C0005516",
"name": "markers",
"pos": [
246,
253
]
} |
milk products were found to contain less than 0.1-3.6 ppb npyr , less than 0.1-5.7 ppb ndma and less than 0.1-0.7 ppb npip , while in flavourings the nitrosamine concentrations were less than 0.1-10.3 ppb npyr , less than 0.1-3.6 ppb ndma and less than 0.1-0.9 ppb npip . | NA | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
150,
161
]
} | {
"id": "C0027253",
"name": "npyr",
"pos": [
205,
209
]
} |
milk products were found to contain less than 0.1-3.6 ppb npyr , less than 0.1-5.7 ppb ndma and less than 0.1-0.7 ppb npip , while in flavourings the nitrosamine concentrations were less than 0.1-10.3 ppb npyr , less than 0.1-3.6 ppb ndma and less than 0.1-0.9 ppb npip . | NA | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
150,
161
]
} | {
"id": "C0012431",
"name": "ndma",
"pos": [
234,
238
]
} |
subacute toxicity of diethylstilboestrol and hexoestrol in the female rat , and the effects of clomiphene pretreatment . | NA | {
"id": "C0012203",
"name": "diethylstilboestrol",
"pos": [
21,
40
]
} | {
"id": "C0019467",
"name": "hexoestrol",
"pos": [
45,
55
]
} |
two groups , each of ten female rats , were orally dosed with the synthetic oestrogens diethylstilboestrol ( des ; 6 mg/kg day ) and hexoestrol ( 60 mg/kg/day ) for 6 wk . | NA | {
"id": "C0012203",
"name": "diethylstilboestrol",
"pos": [
87,
106
]
} | {
"id": "C0019467",
"name": "hexoestrol",
"pos": [
133,
143
]
} |
the presence of angioedema ( 10 cases ) , dermographism ( 2 cases ) , atopy ( 4 cases ) , drug reactions ( 6 cases ) , and infections ( 6 cases ) was similar to that seen in cases of urticaria without diffuse dermal neutrophilia . | NA | {
"id": "C0002994",
"name": "angioedema",
"pos": [
16,
26
]
} | {
"id": "C0042109",
"name": "urticaria",
"pos": [
183,
192
]
} |
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