text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
thyroid biopsy is recommended as a useful tool in differentiating this disease from other thyroid diseases causing hyperthyroidism . | NA | {
"id": "C0040128",
"name": "disease",
"pos": [
71,
78
]
} | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
115,
130
]
} |
in addition to a 90 % chance of developing retinoblastoma , patients inheriting a mutant rb gene have a high incidence of second nonocular malignancies , suggesting a role for this gene in other tumors as well . | NA | {
"id": "C0085183",
"name": "second",
"pos": [
122,
128
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
195,
201
]
} |
linkage studies between the autosomal recessive type ( arpkd ) and the 3 ' hvr of the alpha-globin gene cluster showed that the arpkd and adpkd are not allelic . | NA | {
"id": "C0085548",
"name": "arpkd",
"pos": [
55,
60
]
} | {
"id": "C0022680",
"name": "adpkd",
"pos": [
138,
143
]
} |
the specificity of rb-aid was demonstrated by the fact that the antibodies bound only to mab 12 and not to any other murine monoclonal antibody tested . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
64,
74
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
89,
92
]
} |
and the occurrence of ab enhancing the 125i-hgh binding to five mab depending upon the individuals and the time of immunization . | NA | {
"id": "C0003241",
"name": "ab",
"pos": [
22,
24
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
64,
67
]
} |
the data suggest that the humoral response to different epitopes of a protein antigen during the maturation of the immune response is a stochastic process leading to transient humoral immunodominance , enhancing ab populations and heterocliticity , depending upon individual characteristics , either in outbred or inbred populations . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
56,
64
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
78,
85
]
} |
homogeneous populations of human mast cells were differentiated and grown by culturing bone marrow cells in the presence of conditioned medium derived from lectin-stimulated human peripheral blood mononuclear cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
38,
43
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
180,
214
]
} |
the level of activation of peritoneal macrophages following subcutaneous inoculation of resistant ( c57bl ) and susceptible ( balb/c ) mice was assessed by monitoring superoxide anion and hydrogen peroxide production and also tumour cell cytostasis . | NA | {
"id": "C0038836",
"name": "superoxide anion",
"pos": [
167,
183
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
197,
205
]
} |
the secretory evolution of the thymic hormones ( thymulin , thymosin alpha 1 and thymopoietin ) in cultured thymic reticuloepithelial cells ( trec ) was studied by immunocytochemical techniques using monoclonal anti-thymulin or anti-thymosin alpha 1 and polyclonal anti-thymopoietin antibodies ( ab ) . | NA | {
"id": "C0040114",
"name": "thymic hormones",
"pos": [
31,
46
]
} | {
"id": "C0040105",
"name": "thymopoietin",
"pos": [
270,
282
]
} |
twenty-six essential hypertensive patients were entered into a protocol to assess the blood pressure and renal effects of the dihydropyridine calcium antagonist nifedipine ( 30-120 mg/day given in divided doses ) administered for 4 weeks . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium",
"pos": [
126,
149
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
161,
171
]
} |
auranofin ( aur ) , a new oral gold compound valuable in treatment of patients with rheumatoid arthritis , is known to have an inhibitory effect on adp- and epinephrine-induced platelet aggregation in vitro . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
0,
9
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
31,
35
]
} |
the purpose of this study was to quantitate biochemically and to localize histochemically the proteases cathepsin b ( cath b ) , dipeptidyl peptidase i ( dpp i ) , and dipeptidyl peptidase ii ( dpp ii ) in experimental pulmonary granulomatosis and fibrosis . | NA | {
"id": "C0007428",
"name": "cathepsin",
"pos": [
104,
113
]
} | {
"id": "C0058361",
"name": "dipeptidyl peptidase i",
"pos": [
168,
190
]
} |
in our previous study ( takada et al. , 1986a ) , we showed that the bamhi e fragment of epstein-barr virus ( ebv ) dna induces a nuclear antigen that is detected by human antisera against ebv-determined nuclear antigen ( ebna ) , when transfected into baby hamster kidney ( bhk ) cells . | NA | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
130,
145
]
} | {
"id": "C0116397",
"name": "ebv",
"pos": [
189,
192
]
} |
in tissue sections of normal epithelium from the cervix uteri and the oral cavity , the maturing keratinocytes in the prickle-cell layers were moderately or strongly stained when antiserum against crbp was used , while the proliferating cells in the basal-cell layer were stained only lightly if at all . | NA | {
"id": "C0022567",
"name": "layers",
"pos": [
131,
137
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
246,
249
]
} |
regardless of sports activity , oligomenorrheic subjects had substantially lower body weight relative to stature and were leaner than subjects of the other menstrual categories . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
86,
92
]
} | {
"id": "C0039870",
"name": "leaner",
"pos": [
122,
128
]
} |
the structure readily fitted proline and hydroxyproline residues and required glycine as every third residue in each of the three chains . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
29,
36
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
41,
55
]
} |
the different binding capacity for bilirubin displayed by the two proteins is likely to be the consequence of small differences in the physico-chemical properties of some amino acid residues close to the bilirubin binding site , as indicated by ph-titration experiments of the intrinsic albumin fluorescence . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
66,
74
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
287,
294
]
} |
the amino acid composition of scgth is rich in aspartic acid/asparagine , glutamic acid/glutamine , valine , proline and half cystine . | NA | {
"id": "C0061472",
"name": "glutamic",
"pos": [
74,
82
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
88,
97
]
} |
although monoclonal antibody to keratan sulfate , used as a marker for stromal fibroblasts , bound to most of the scar tissue , the antibody failed to bind to the posterior scar tissue positive for type iii collagen . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
9,
28
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
132,
140
]
} |
uptake and excretion of imp were shown in kidneys and stomach , which may be the main route of the excretion of imp and their metabolites . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
11,
20
]
} | {
"id": "C1373186",
"name": "route of",
"pos": [
86,
94
]
} |
at the mineralization front of the epiphyseal growth plate large quantities of calcium ( ca ) are necessary to form the mineral ( a ca-phosphate ) . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
79,
86
]
} | {
"id": "C0006711",
"name": "ca-phosphate",
"pos": [
132,
144
]
} |
moreover , lanthanum itself as well as lanthanides other than cerium , e.g. , gadolinium and didymium ( praseodymium , neodymium ) , were successfully applied and can be recommended as capture agents for phosphatase cytochemistry . | NA | {
"id": "C0023031",
"name": "lanthanum",
"pos": [
11,
20
]
} | {
"id": "C0205838",
"name": "lanthanides",
"pos": [
39,
50
]
} |
moreover , lanthanum itself as well as lanthanides other than cerium , e.g. , gadolinium and didymium ( praseodymium , neodymium ) , were successfully applied and can be recommended as capture agents for phosphatase cytochemistry . | NA | {
"id": "C0205838",
"name": "lanthanides",
"pos": [
39,
50
]
} | {
"id": "C0007828",
"name": "cerium",
"pos": [
62,
68
]
} |
moreover , lanthanum itself as well as lanthanides other than cerium , e.g. , gadolinium and didymium ( praseodymium , neodymium ) , were successfully applied and can be recommended as capture agents for phosphatase cytochemistry . | NA | {
"id": "C0205838",
"name": "lanthanides",
"pos": [
39,
50
]
} | {
"id": "C0016911",
"name": "gadolinium",
"pos": [
78,
88
]
} |
moreover , lanthanum itself as well as lanthanides other than cerium , e.g. , gadolinium and didymium ( praseodymium , neodymium ) , were successfully applied and can be recommended as capture agents for phosphatase cytochemistry . | NA | {
"id": "C0205838",
"name": "lanthanides",
"pos": [
39,
50
]
} | {
"id": "C0032904",
"name": "praseodymium",
"pos": [
104,
116
]
} |
moreover , lanthanum itself as well as lanthanides other than cerium , e.g. , gadolinium and didymium ( praseodymium , neodymium ) , were successfully applied and can be recommended as capture agents for phosphatase cytochemistry . | NA | {
"id": "C0205838",
"name": "lanthanides",
"pos": [
39,
50
]
} | {
"id": "C0027599",
"name": "neodymium",
"pos": [
119,
128
]
} |
in adult mating rats , significant amounts of zinc were found in the proximal portion of the epididymis , whereas in non-mating , mature and immature young rats , this heavy metal was most prominent in the distal portion of this organ . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
46,
50
]
} | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
168,
179
]
} |
the presence of a retinoid in nuclei , mitochondria and cytoplasmic membranes suggests an additional role of vitamin a in other metabolic processes . | NA | {
"id": "C0035339",
"name": "retinoid",
"pos": [
18,
26
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
109,
118
]
} |
neuropeptide ( neuropeptide y , neurotensin , vasoactive intestinal polypeptide , substance p , calcitonin gene-related peptide , somatostatin ) immunohistochemistry and ultrastructure of renal nerves . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
0,
12
]
} | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
15,
29
]
} |
neuropeptide ( neuropeptide y , neurotensin , vasoactive intestinal polypeptide , substance p , calcitonin gene-related peptide , somatostatin ) immunohistochemistry and ultrastructure of renal nerves . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
0,
12
]
} | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
32,
43
]
} |
neuropeptide ( neuropeptide y , neurotensin , vasoactive intestinal polypeptide , substance p , calcitonin gene-related peptide , somatostatin ) immunohistochemistry and ultrastructure of renal nerves . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
0,
12
]
} | {
"id": "C0006669",
"name": "calcitonin gene-related peptide",
"pos": [
96,
127
]
} |
the method is very useful for protein estimation in salt -- and alcohol -- free albumin bulk solutions and as an additional end product test for albumin and immunoglobulin solutions ; | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
30,
37
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
145,
152
]
} |
kallikrein released from a prekallikrein substrate preparation by pka in the sample is determined using the synthetic substrate s-2302 ( h-d-pro-phe-arg-pna ) . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
0,
10
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
27,
40
]
} |
consumption coagulopathy was developed in three cases of liver cirrhosis and a case of haemophilia b upon administration of factor ix preparations which had been tested by the manufacturers for the absence of active clotting factors according to the japanese minimum requirements for biological products . | NA | {
"id": "C0015491",
"name": "factor ix preparations",
"pos": [
124,
146
]
} | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
216,
232
]
} |
after these , smaller protein impurities such as albumin are eluted and then fragments from the proteolytic breakdown of igg . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
22,
29
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
49,
56
]
} |
embryo fibroblasts were fused to established chinese hamster cells and somatic cell hybrids were selected . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
7,
18
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
61,
66
]
} |
hydrocortisone suppressed release of pge and f from inflamed synovial membrane in vivo , and did not influence pg release in vitro . | NA | {
"id": "C0033559",
"name": "pge",
"pos": [
37,
40
]
} | {
"id": "C0033554",
"name": "pg",
"pos": [
111,
113
]
} |
therefore , this failure to detect glomerular staining with anti-hbs antiserum may mean that mn is caused by some other antigen , of a lower molecular weight , associated with hbv , but not necessarily by hb surface antigen . | NA | {
"id": "C0003241",
"name": "anti-hbs",
"pos": [
60,
68
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
69,
78
]
} |
carcinoma-type characteristic pattern was also demonstrated in terms of relative amounts of non-sulfated ( ha ) and sulfated ( chs , ds , hs ) mucopolysaccharides : in squamous cell carcinoma and adenocarcinoma sulfated mucopolysaccharides were predominant ( 73 to 78 % of total mucopolysaccharides ) , whereas in small cell undifferentiated carcinoma sulfated ones were diminished ( 25 % of total mucopolysaccharides ) . | NA | {
"id": "C0019143",
"name": "hs",
"pos": [
128,
130
]
} | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
398,
417
]
} |
in vitro effects of diazepam , desmethyldiazepam & nitrazepam on atpase activity of human fetal brain . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
20,
28
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
31,
48
]
} |
studies with ( des-asp ) aii and ( des-asp , arg ) aii showed that the delayed pressor response to ai following sq20,881 administration could not be accounted for by circulating peptide metabolites of ai or aii . | NA | {
"id": "C0003006",
"name": "ai",
"pos": [
25,
27
]
} | {
"id": "C0003018",
"name": "ai",
"pos": [
207,
209
]
} |
in order to determine if vasopressin is necessary for the development of doc-salt hypertension , rats with hereditary diabetes insipidus ( di ) and normal long-evans rats ( le ) were unilaterally nephrectomized , treated with doc pivalate ( 30 mg/kg . week ) and given saline to drink for 8 weeks . | NA | {
"id": "C0011710",
"name": "doc",
"pos": [
73,
76
]
} | {
"id": "C0057420",
"name": "doc pivalate",
"pos": [
226,
238
]
} |
antiestradiol antisera were raised in rabbits by immunization with a steroid-protein conjugate whole antisera and purified antiestradiol antibodies were reacted with heat-killed and formalin-fixed bacteria from the protein-a-bearing strain of staphilococcus aureus ( cowan i , nctc 8530 ) . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
14,
22
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
137,
147
]
} |
a single intratracheal 0.1-ml instillation of a calcium-arsenate containing vineyard pesticide induced multi-focal bronchogenic adenocarcinomas and bronchiolar-alveolar-cell carcinomas in nine out of 15 treated bd rats . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
128,
143
]
} | {
"id": "C0007120",
"name": "bronchiolar-alveolar-cell carcinomas",
"pos": [
148,
184
]
} |
the catecholamine fraction was separated further on a column of amberlite irc-50 which was coupled with a device for the automated performance of the trihydroxyindole method ( epinephrine and norepinephrine ) or the 4-aminobenzoic acid-oxidation method ( dopamine ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
176,
187
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
192,
206
]
} |
the lower detection limits were 0.02 ng for epinephrine and dopamine , and 0.04 ng for norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
44,
55
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
87,
101
]
} |
plasma catecholamine contents of healthy adults at rest were epinephrine 0.07 +/- 0.01 ng/ml ( n = 19 ) , norepinephrine 0.27 +/- 0.03 ng/ml ( n = 19 ) and dopamine 0.22 +/- 0.03 ng/ml ( n = 26 ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
61,
72
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
106,
120
]
} |
using a c18-bonded reversed-phase column with an acetonitrile-acetate buffer mobile phase theophylline is completely resolved not only from other dietary xanthines and their metabolites but also from co-administered drugs such as paracetamol and phenobarbitone . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
90,
102
]
} | {
"id": "C0043318",
"name": "xanthines",
"pos": [
154,
163
]
} |
analysis of the basic 5-nitroimidazole nimorazole in blood by reversed-phase high-performance liquid chromatography , and its application to pharmacokinetic studies in individual mice . | NA | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
24,
38
]
} | {
"id": "C0028095",
"name": "nimorazole",
"pos": [
39,
49
]
} |
a thin-layer chromatographic method has been developed for the detection of major nebramycin components , for the separation of tobramycin from other components and for studying the hydrolysis of carbamoyl derivatives and procedures for isolation and purification . | NA | {
"id": "C0027521",
"name": "nebramycin",
"pos": [
82,
92
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
128,
138
]
} |
gas chromatographic analysis of ditigoxigenin and digoxigenin , the genins of the cardenolide glycosides digitoxin and digoxin , can not be done without derivatization . | NA | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
50,
61
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
119,
126
]
} |
the characteristics of lithium iodide-containing poly ( ethylene glycol ) as a gas chromatographic stationary phase have been evaluated in terms of partial free energy of transfer ( delta g t0 ) from poly ( ethylene glycol ) to the lithium iodide-poly ( ethylene glycol ) system for a variaty of amides ( n-fatty acid amides , lactams , benzamides , anilides , nicotinamides , isonicotinamides , barbiturates , pyrazolones ) and several amines . | NA | {
"id": "C0002482",
"name": "amides",
"pos": [
296,
302
]
} | {
"id": "C0022914",
"name": "lactams",
"pos": [
327,
334
]
} |
the characteristics of lithium iodide-containing poly ( ethylene glycol ) as a gas chromatographic stationary phase have been evaluated in terms of partial free energy of transfer ( delta g t0 ) from poly ( ethylene glycol ) to the lithium iodide-poly ( ethylene glycol ) system for a variaty of amides ( n-fatty acid amides , lactams , benzamides , anilides , nicotinamides , isonicotinamides , barbiturates , pyrazolones ) and several amines . | NA | {
"id": "C0002482",
"name": "amides",
"pos": [
296,
302
]
} | {
"id": "C0005029",
"name": "benzamides",
"pos": [
337,
347
]
} |
the characteristics of lithium iodide-containing poly ( ethylene glycol ) as a gas chromatographic stationary phase have been evaluated in terms of partial free energy of transfer ( delta g t0 ) from poly ( ethylene glycol ) to the lithium iodide-poly ( ethylene glycol ) system for a variaty of amides ( n-fatty acid amides , lactams , benzamides , anilides , nicotinamides , isonicotinamides , barbiturates , pyrazolones ) and several amines . | NA | {
"id": "C0002482",
"name": "amides",
"pos": [
296,
302
]
} | {
"id": "C0003035",
"name": "anilides",
"pos": [
350,
358
]
} |
[ enzymochemical studies on snake venoms . v. purification of lethal protein ac3-proteinase in the venom of agkistrodon acutus ( author 's transl ) ] . | NA | {
"id": "C0037380",
"name": "snake venoms",
"pos": [
28,
40
]
} | {
"id": "C0042479",
"name": "venom",
"pos": [
99,
104
]
} |
autoradiographic analysis has revealed that the dna in the extrusion body is a representative of the dna in the macronucleus indicating a random distribution of dna between daughter nuclei and extrusion body . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
48,
51
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
189,
190
]
} |
blastocrithidia culicis , crithidia deanei , crithidia fasciculata , herpetomonas samuelpessoai , leptomonas seymouri and leishmania tarentolae grown in cultures were compared by electrophoretic mobility for isoenzymes in 6 enzymes . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
208,
218
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
224,
231
]
} |
a method for preparation of translatable rna from tetrahymena will make possible the comparison of messenger rnas associated with specific cell structures and with different developmental events . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
41,
44
]
} | {
"id": "C0035696",
"name": "messenger",
"pos": [
99,
108
]
} |
proteus infections were four times more common among boys than girls , and under the age of three the proportion of boys with bacteriuria exceeded that of girls.dip-slide culture is a valuable tool in the diagnosis , management , and follow-up of urinary tract infection . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
126,
137
]
} | {
"id": "C0042029",
"name": "of urinary tract infection",
"pos": [
244,
270
]
} |
non-covalent photoproducts can be conveniently removed from labeled membrane preparations by exchange into lipid vesicles prepared from electroplax membrane lipids . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
107,
112
]
} | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
148,
163
]
} |
the nonmetastatic lines were characterized by ganglioside patterns depleted in the precursor ganglioside gm3 ( sialic acid-galactose-glucose-ceramide ) and elevated in the products of the monosialoganglioside pathway . | NA | {
"id": "C0017082",
"name": "ganglioside",
"pos": [
46,
57
]
} | {
"id": "C0016897",
"name": "ganglioside gm3",
"pos": [
93,
108
]
} |
the iodinated proteins were solubilized in 0.5 % nonidet p-40 and subjected to affinity chromatography on sepharose-conjugated lectins ( ricinus communis agglutinins i or ii , soybean agglutinin , concanavalin a , or wheat germ agglutinin ) and analyzed by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
14,
22
]
} | {
"id": "C0023206",
"name": "lectins",
"pos": [
127,
134
]
} |
almost all the iodinated proteins bound to one or more of the sepharose-conjugated lectins , presumptive evidence that these peptides are glycosylated . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
25,
33
]
} | {
"id": "C0023206",
"name": "lectins",
"pos": [
83,
90
]
} |
incubation of fibroblasts with 0.2 mm dibucaine for 3 h at 37 degrees c results in a twofold to threefold increase in insulin binding , with an increase in average number of binding sites ( ka = 3.0 x 10 ( 7 ) m-1 ) from 9 x 10 ( 3 ) per cell . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
14,
25
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
238,
242
]
} |
total rna and ribosomal rna from dictyostelium , when added to rna-free myosin , also induced the extensive linear aggregation seen with the copurified rna/myosin complex , although higher concentrations of rna were required to obtain quantitatively the same effect . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
14,
27
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
207,
210
]
} |
plasmalemma of renal tubule cells contained more total glycosaminoglycans , hyaluronic acid , chondroitin-4 sulfates and chondroitin-6 sulfates , and less dermatan sulfates and heparin sulfates than liver plasma membranes . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
55,
73
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
177,
184
]
} |
the effects of thiourea and of several substituted thioureas -- phenylthiourea , alpha-naphtylthiourea , metiamide , and burimamide -- on dynein atpase have been studied . | NA | {
"id": "C0039958",
"name": "thioureas",
"pos": [
51,
60
]
} | {
"id": "C0031505",
"name": "phenylthiourea",
"pos": [
64,
78
]
} |
the effects of thiourea and of several substituted thioureas -- phenylthiourea , alpha-naphtylthiourea , metiamide , and burimamide -- on dynein atpase have been studied . | NA | {
"id": "C0039958",
"name": "thioureas",
"pos": [
51,
60
]
} | {
"id": "C0025845",
"name": "metiamide",
"pos": [
105,
114
]
} |
the effects of thiourea and of several substituted thioureas -- phenylthiourea , alpha-naphtylthiourea , metiamide , and burimamide -- on dynein atpase have been studied . | NA | {
"id": "C0039958",
"name": "thioureas",
"pos": [
51,
60
]
} | {
"id": "C0006408",
"name": "burimamide",
"pos": [
121,
131
]
} |
the effects of thiourea and phenylthiourea can be prevented by very low concentrations of beta-mercaptoethanol or dithiothreitol . | NA | {
"id": "C0039958",
"name": "thiourea",
"pos": [
15,
23
]
} | {
"id": "C0031505",
"name": "phenylthiourea",
"pos": [
28,
42
]
} |
this observation , together with our earlier work with dihydrocytochalasin b , establishes that the pharmacologic effects of cb on fibroblasts result from the binding of the drug to two distinct classes of receptors and that these receptors interact with different parts of the cytochalasin molecule . | NA | {
"id": "C0010737",
"name": "cb",
"pos": [
125,
127
]
} | {
"id": "C0010739",
"name": "cytochalasin",
"pos": [
278,
290
]
} |
when 125i-thrombin was incubated with foreskin fibroblasts , cervical carcinoma cells or fibrosarcoma cells of human origin , or with secondary chick embryo cells or chinese hamster lung cells , it became directly linked to its cell surface receptors . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
47,
58
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
187,
192
]
} |
cumulative dosage of doxorubicin or daunomycin correlated with a reduced efrn ( p less than 0.001 ) . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
21,
32
]
} | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
36,
46
]
} |
we conclude that ( 1 ) the efrn can noninvasively detect significant changes in cardiac function at low cumulative doses of doxorubicin or daunomycin and ( 2 ) the efrn may be useful in evaluating cardiac function in patients during doxorubicin or daunomycin therapy . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
124,
135
]
} | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
248,
258
]
} |
labetalol did not cause any significant changes in plasma noradrenaline and adrenaline at rest or during exercise . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
58,
71
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
76,
86
]
} |
complement analyses performed on serially collected plasma samples from 10 patients during acute infectious pneumonia or bronchopneumonia showed normal or increased values for hemolytic activity and clq , c4 , c3 , and factor b levels . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
0,
10
]
} | {
"id": "C0033453",
"name": "factor b",
"pos": [
219,
227
]
} |
it is suggested that certain patients with oculopharyngeal dystrophy may pass through an initial phase of secondary muscle inflammation similar to that seen in some other heritable myopathies . | NA | {
"id": "C0027121",
"name": "muscle",
"pos": [
116,
122
]
} | {
"id": "C0026848",
"name": "myopathies",
"pos": [
181,
191
]
} |
xanthines ( caffeine , theobromine , and theophylline ) were better inhibitors of camp pde than of cgmp pde . | NA | {
"id": "C0043318",
"name": "xanthines",
"pos": [
0,
9
]
} | {
"id": "C0006644",
"name": "caffeine",
"pos": [
12,
20
]
} |
xanthines ( caffeine , theobromine , and theophylline ) were better inhibitors of camp pde than of cgmp pde . | NA | {
"id": "C0043318",
"name": "xanthines",
"pos": [
0,
9
]
} | {
"id": "C0039763",
"name": "theobromine",
"pos": [
23,
34
]
} |
xanthines ( caffeine , theobromine , and theophylline ) were better inhibitors of camp pde than of cgmp pde . | NA | {
"id": "C0043318",
"name": "xanthines",
"pos": [
0,
9
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
41,
53
]
} |
myopic patients often fear that they have increased their refractive error by their own behavior . | NA | {
"id": "C0027092",
"name": "myopic",
"pos": [
0,
6
]
} | {
"id": "C0034951",
"name": "refractive error",
"pos": [
58,
74
]
} |
( 3 ) overcorrecting the myopic refractive error and failure to appreciate the symptoms that result from overcorrection ; | NA | {
"id": "C0027092",
"name": "myopic",
"pos": [
25,
31
]
} | {
"id": "C0034951",
"name": "refractive error",
"pos": [
32,
48
]
} |
in patients who do not respond to antimicrobial therapy , transfusion of granulocytes and empiric use of antifungal drugs should be considered . | NA | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
34,
47
]
} | {
"id": "C0003308",
"name": "antifungal drugs",
"pos": [
105,
121
]
} |
[ on the polymorphism of barbiturates in powders and tablets - part 3 : the effect of the pressing power on the modification of barbital ( author 's transl ) ] . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
25,
37
]
} | {
"id": "C0004743",
"name": "barbital",
"pos": [
128,
136
]
} |
[ gammagraphy and sialography in the diagnosis of salivary gland diseases . ii . morphological and functional study of salivary glands in sialosis , salivary syndromes and tumor pathology ] . | NA | {
"id": "C0036093",
"name": "the",
"pos": [
33,
36
]
} | {
"id": "C0037036",
"name": "sialosis",
"pos": [
138,
146
]
} |
the characteristic complement profile of the patients with emc ( low ch50 and c4 , normal c3pa ) , not related to albumin levels , can help to differentiate this disease from chronic liver disease without cryoglobulins . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
19,
29
]
} | {
"id": "C0033453",
"name": "c3pa",
"pos": [
90,
94
]
} |
the memory cytolytic t lymphocyte ( ctl ) response of mice was studied in vitro using peripheral blood leucocytes ( pbl ) of donors previously immunized with allogeneic cells as responding cells , and particulate alloantigen for stimulation . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
158,
174
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
189,
194
]
} |
analysis of cell populations enriched for multinucleated cells has revealed complementation leading to iduronate sulfatase activity in heterokaryons derived from iduronate sulfatase-deficient fibroblasts expressing the hunter and multiple sulfatase-deficiency mutations . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
12,
16
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
192,
203
]
} |
all of the hybrids were fibroblasts showing extinction of the multiple developmental potentialities of the teratocarcinoma cell parent , irrespective of whether the teratocarcinoma parent was diploid or tetraploid . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
24,
35
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
123,
127
]
} |
application via drinking water in a dose of 115 mg/l results in ea quantities of 0.11 to 0.2 meg/cm3 detected in the blood during the entire course of treatment with therapeutic water . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
16,
30
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
178,
183
]
} |
glutaraldehyde prefixation causes a considerable inactivation of the acid phosphatase of yeast protoplasts in dependence on the duration of aldehyde influence . | NA | {
"id": "C0017814",
"name": "glutaraldehyde",
"pos": [
0,
14
]
} | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
140,
148
]
} |
a partially purified extract of dna methylases from e. coli k-12 containing dna-adenine as well as dna-cytosine methylase activities has been examined with respect to different dna species as substrates . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
177,
180
]
} |
addition of t3 dna delays this process for 30 s and reduces the rate with which the enzyme activity is lost indicating that a labile binary complex between t3 dna and polymerase must have been formed . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
15,
18
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
184,
185
]
} |
therefore , the judgement of the presence of e. coli or coliforms in samples of drinking water must impact highly on the improvement of the water quality by disinfection in future . | NA | {
"id": "C0599638",
"name": "samples",
"pos": [
69,
76
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
140,
145
]
} |
further biophysical properties are a direct function of the pathway along which random mutation in nucleic acids is converted into continuous protein - ( specifically enzyme ) - function , from there into organismic phenotype with fitness components which may , or may not , correspond to identifiable structural units in dna . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
99,
112
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
322,
325
]
} |
plasma levels of unconjugated estetrol and estriol and of total estriol in normal human pregnancy . | NA | {
"id": "C0014899",
"name": "estetrol",
"pos": [
30,
38
]
} | {
"id": "C0014927",
"name": "estriol",
"pos": [
64,
71
]
} |
the course of normal pregnancy in 54 patients was monitored by weekly assays of unconjugated estriol ( e3u ) , total estriol ( e3t ) and unconjugated estetrol ( e4u ) . | NA | {
"id": "C0014927",
"name": "estriol",
"pos": [
93,
100
]
} | {
"id": "C0014899",
"name": "estetrol",
"pos": [
150,
158
]
} |
investigation of the effect of pretreatment with other barbiturates showed that barbital , butobarbital , pentobarbital and amobarbital produced microsomal induction . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
55,
67
]
} | {
"id": "C0004743",
"name": "barbital",
"pos": [
127,
135
]
} |
investigation of the effect of pretreatment with other barbiturates showed that barbital , butobarbital , pentobarbital and amobarbital produced microsomal induction . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
55,
67
]
} | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
106,
119
]
} |
investigation of the effect of pretreatment with other barbiturates showed that barbital , butobarbital , pentobarbital and amobarbital produced microsomal induction . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
55,
67
]
} | {
"id": "C0002640",
"name": "amobarbital",
"pos": [
124,
135
]
} |
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