text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the effect of e. coli endotoxin ( lps ) on human monocytes and peritoneal macrophages ( pec ) during in vitro differentiation was studied . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
22,
31
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
34,
37
]
} |
the presence of non-toxic concentrations of e. coli endotoxin ( lps ) during the in vitro interaction of normal human monocytes and a human tumour cell line ( nhik 3025 ) enhanced monocyte-mediated target cell cytostasis and cytolysis . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
52,
61
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
64,
67
]
} |
pretreating the toxin with formaldehyde , the b-type enterotoxin could be demonstrated rapidly with appropriate sensitivity by laurell 's electroimmune diffusion method . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
16,
21
]
} | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
53,
64
]
} |
in an attempt to relate endotoxin structural components to the ability to enhance tur , a variety of whole lps 's , endotoxic glycolipids and ps preparations were compared . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
24,
33
]
} | {
"id": "C0023810",
"name": "lps 's",
"pos": [
107,
113
]
} |
based on review examination of 224 patients 5 years after their ankle fractures , the authors demonstrate a significant worsening of prognosis with fractures of the anterior or posterior tibial margin . | NA | {
"id": "C0159877",
"name": "ankle fractures",
"pos": [
64,
79
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
148,
157
]
} |
the decreased peptide hydrolase levels during episodes when protease 'spillage ' into the bloodstream is elevated , suggests a more rapid clearance of alpha-macroglobulin-protease complexes associated with inflammation . | NA | {
"id": "C0030940",
"name": "peptide hydrolase",
"pos": [
14,
31
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
171,
179
]
} |
endotoxin lipopolysaccharides escherichia coli o26 : b6 and e. coli o127 : b8 were weak inducers of aggregation in normal guinea-pig platelet-rich plasma ( prp ) , even in the presence of ca2+ . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
0,
9
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
10,
29
]
} |
although acute leukemia may occur in a higher than expected frequency in patients with solid tumors because of a possible increased risk of a second neoplasm , it seems more likely that the acute leukemia is related to the radiotherapy and/or chemotherapy administered to treat the first neoplasm . | NA | {
"id": "C0085183",
"name": "second neoplasm",
"pos": [
142,
157
]
} | {
"id": "C0027651",
"name": "neoplasm",
"pos": [
288,
296
]
} |
the response rate of apl to chemotherapy regimens that contain an anthracycline is comparable to that of acute myelogenous leukemia . | NA | {
"id": "C0023487",
"name": "apl",
"pos": [
21,
24
]
} | {
"id": "C0023467",
"name": "acute myelogenous leukemia",
"pos": [
105,
131
]
} |
albinism : hematologic-storage disease , susceptibility to skin cancer , and optic neuronal defects shared in all types of oculocutaneous and ocular albinism . | NA | {
"id": "C0001916",
"name": "albinism",
"pos": [
0,
8
]
} | {
"id": "C0078917",
"name": "ocular albinism",
"pos": [
142,
157
]
} |
gel isoelectrofocusing of the pooled allergenic fractions revealed two major protein bands with pi 's around 5.6 and 5.7 , probably corresponding to antigens nos.7-8 and no . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
37,
47
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
149,
157
]
} |
more than 90 % of the allergenic activity in the fractions was located in the protein peak c ( mol . wt . 10 000-17 000 ) containing antigens 7-8 . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
22,
32
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
133,
141
]
} |
peak b contained allergens ( antigen 2 ) distinct from those of peak c by the crie and by the rast . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
17,
26
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
29,
36
]
} |
the present study was undertaken to verify that mites are not the only allergens in house dust extracts and that other allergens such as cat epithelia can also be responsible for house dust hypersensitivities detected both by house dust skin tests and house dust rast studies . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
71,
80
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
252,
262
]
} |
in order to determine whether mite or epithelia fixed on a solid phase could remove not only the ige antibodies reactive with the homologous allergens , but also the ige antibodies reactive with house dust allergens , the authors have absorbed 10 sera of house dust allergic patients with solid phase mite or epithelia . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
141,
150
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
255,
265
]
} |
this is in accordance with the hypothesis that house dust is not an allergen per se , but rather a complex mosaic of several allergens including mite , animal epithelia , etc . | NA | {
"id": "C0524581",
"name": "house dust",
"pos": [
47,
57
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
125,
134
]
} |
the fracture should be looked for in trauma cases in which the anterior wall of the maxillary sinus is depressed . | NA | {
"id": "C0016658",
"name": "fracture",
"pos": [
4,
12
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
37,
43
]
} |
a significant increase in alanine and a decrease in glutamic acid was observed while no change was observed in the content of other amino acids belonging to the glutamate family . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
26,
33
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
132,
143
]
} |
studying the effects , on the isolated rat duodenum motricity , of ten compounds precursors or metabolites of catecholamines , the following results were obtained : the direct metabolites of epinephrine and norepinephrine ( metanephrine , normetanephrine ) , are either ineffective at concentrations below 5 x 10 ( -6 ) m , or weakly inhibitory at higher concentrations . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
191,
202
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
207,
221
]
} |
studying the effects , on the isolated rat duodenum motricity , of ten compounds precursors or metabolites of catecholamines , the following results were obtained : the direct metabolites of epinephrine and norepinephrine ( metanephrine , normetanephrine ) , are either ineffective at concentrations below 5 x 10 ( -6 ) m , or weakly inhibitory at higher concentrations . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
191,
202
]
} | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
242,
254
]
} |
studying the effects , on the isolated rat duodenum motricity , of ten compounds precursors or metabolites of catecholamines , the following results were obtained : the direct metabolites of epinephrine and norepinephrine ( metanephrine , normetanephrine ) , are either ineffective at concentrations below 5 x 10 ( -6 ) m , or weakly inhibitory at higher concentrations . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
207,
221
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
239,
254
]
} |
the catecholamine precursor , dopamine , the related compounds dopa , 3 methoxytyramine , and to a lesser extent , 3-o methyl dopa and homovanillic acid , have excito-motor effects at concentrations ranging mainly from 10 ( -7 ) m to 10 ( -5 ) m . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
4,
17
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
126,
130
]
} |
maximum fresh weight gains and dry weights were achieved by larvae fed reference levels of all essential amino acids except phenylalanine , threonine and tryptophan . | NA | {
"id": "C0002525",
"name": "essential amino",
"pos": [
95,
110
]
} | {
"id": "C0040005",
"name": "threonine",
"pos": [
140,
149
]
} |
plasma glutamic oxaloacetic transaminase ( got , aspartate and aminotransferase ) activity increased , and carotenoid and total protein levels decreased in inoculated turkeys but not in the pair-fed turkeys , indicating that these changes were caused by the infection and not by reduced food intake . | NA | {
"id": "C0004002",
"name": "glutamic",
"pos": [
7,
15
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
63,
79
]
} |
the immunological characteristics of feline beta-hexosaminidase ( beta-d-n-acetylglucosaminidase , ec 3.2.1.30 ) isoenzymes , hex a and hex b , were studied . | NA | {
"id": "C0005270",
"name": "beta-hexosaminidase",
"pos": [
44,
63
]
} | {
"id": "C0162330",
"name": "hex a",
"pos": [
126,
131
]
} |
the immunological characteristics of feline beta-hexosaminidase ( beta-d-n-acetylglucosaminidase , ec 3.2.1.30 ) isoenzymes , hex a and hex b , were studied . | NA | {
"id": "C0005270",
"name": "beta-hexosaminidase",
"pos": [
44,
63
]
} | {
"id": "C0019481",
"name": "hex b",
"pos": [
136,
141
]
} |
this antigenic profile is comparable to that of the human beta-hexosaminidase isozymes , in which both hex a and hex b share the antigenic determinant , beta , while only hex a possesses the antigenic determinant , alpha . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
5,
14
]
} | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
191,
212
]
} |
this antigenic profile is comparable to that of the human beta-hexosaminidase isozymes , in which both hex a and hex b share the antigenic determinant , beta , while only hex a possesses the antigenic determinant , alpha . | NA | {
"id": "C0005270",
"name": "beta-hexosaminidase",
"pos": [
58,
77
]
} | {
"id": "C0019481",
"name": "hex b",
"pos": [
113,
118
]
} |
this antigenic profile is comparable to that of the human beta-hexosaminidase isozymes , in which both hex a and hex b share the antigenic determinant , beta , while only hex a possesses the antigenic determinant , alpha . | NA | {
"id": "C0005270",
"name": "beta-hexosaminidase",
"pos": [
58,
77
]
} | {
"id": "C0162330",
"name": "hex a",
"pos": [
171,
176
]
} |
these immunological data validate feline gm2 gangliosidosis as a model for human gm2 gangliosidosis type ii , and facilitate the investigation of enzyme replacement therapy . | NA | {
"id": "C0268274",
"name": "gm2 gangliosidosis",
"pos": [
41,
59
]
} | {
"id": "C0036161",
"name": "gm2 gangliosidosis type ii",
"pos": [
81,
107
]
} |
from amino acid determinations , the cuticle is collagen-like with high levels of glycine ( approximately equal to 31 residue % ) , proline ( approximately equal to 20 residue % ) and alanine ( approximately equal to 21 residue % ) although the hydroxyproline ( 2.6 residue % ) content is low . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
5,
15
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
82,
89
]
} |
from amino acid determinations , the cuticle is collagen-like with high levels of glycine ( approximately equal to 31 residue % ) , proline ( approximately equal to 20 residue % ) and alanine ( approximately equal to 21 residue % ) although the hydroxyproline ( 2.6 residue % ) content is low . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
5,
15
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
184,
191
]
} |
from amino acid determinations , the cuticle is collagen-like with high levels of glycine ( approximately equal to 31 residue % ) , proline ( approximately equal to 20 residue % ) and alanine ( approximately equal to 21 residue % ) although the hydroxyproline ( 2.6 residue % ) content is low . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
132,
139
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
245,
259
]
} |
this is probably due to the presence in the membrane antiserum of antibodies specific to the respiratory chain enzymes . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
53,
62
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
66,
76
]
} |
catechol o-methyltransferase ( comt ) obtained from human liver ( hl ) and human placenta ( hp ) was found to be much less active than rat liver ( rl ) comt when norepinephrine , epinephrine , dopamine , and isoproterenol are used as substrates . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
162,
176
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
179,
190
]
} |
on sds polyacrylamide gels , the p400 protein reacts with 125i plant lectins such as 125i con a . | NA | {
"id": "C0304052",
"name": "plant lectins",
"pos": [
63,
76
]
} | {
"id": "C0009630",
"name": "con a",
"pos": [
90,
95
]
} |
gm 126 diploid fibroblasts were fused with a heat-sensitive mouse cell mutant defective in dna synthesis , and primary hybrids were selected at permissive and nonpermissive temperatures in hat medium . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
15,
26
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
66,
70
]
} |
this study clearly indicates that corticosteroid hormones possess a significant inhibitory effect on the proliferative activity of neonatal chondrocytes and upon the latter 's protein synthetic pathways , thereby affecting the normal process of endochondral bone growth . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
34,
48
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
49,
57
]
} |
a tentative pathogenetic interpretation of some cytoimmunological aspects in malignant lymphomas , with particular reference to hodgkin 's disease . | NA | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
77,
96
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
128,
146
]
} |
the order of potencies of alpha-adrenoceptor stimulating amines ( adrenaline greater than noradrenaline greater than dopamine greater than isoprenaline ) is similar in human and canine veins . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
66,
76
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
90,
103
]
} |
at low concentrations they cause contraction of isolated vein strips via a stimulation of alpha-adrenoceptors , at higher concentrations they antagonize the action of noradrenaline on arteries and veins and inhibit the adrenaline-induced platelet aggregation in vitro . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
167,
180
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
219,
229
]
} |
[ effect of fibrin-fibrinogenolysis on the determination of the fibrinogen content and fibrin-fibrinogen degradation products ( fdp ) by means of the fibrin polymerization time ( fpt test ) ] . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
12,
18
]
} | {
"id": "C0163275",
"name": "fibrin-fibrinogen degradation products",
"pos": [
87,
125
]
} |
in some cities facilities are available to reach patients in the very earliest phases of ischaemia or infarction . | NA | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
89,
98
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
102,
112
]
} |
as previously suspected but now confirmed , ventricular fibrillation occurs commonly at this time and depending on whether ischaemia or infarction is the basis of its occurrence , has a variable long-term prognosis . | NA | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
123,
132
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
136,
146
]
} |
lps from bacteroides oralis converted co mainly via the alternative pathway , whereas lps from fusobacterium nucleatum and veillonella parvula const pronounced lipid a-dependent conversion . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
0,
3
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
160,
167
]
} |
these results indicate that colony-stimulating factor production by stimulated leukocytes is regulated by e-series prostaglandins and suggest that prostaglandins function to limit myelopoiesis by inhibiting colony-stimulating factor production and concomitantly the induction of cell proliferation . | NA | {
"id": "C0033559",
"name": "e",
"pos": [
2,
3
]
} | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
147,
161
]
} |
rabbits were immunized with two parenteral injections of wellcome toxoid px389a , wyeth toxoid 20101 , or merck bivalent vaccine . | NA | {
"id": "C0040555",
"name": "toxoid",
"pos": [
66,
72
]
} | {
"id": "C0042210",
"name": "vaccine",
"pos": [
121,
128
]
} |
the 50 microgram doses of each toxoid as well as the 4 x 10 ( 9 ) cells of the bivalent vaccine provided the same magnitude of protection against live-cell challenge with either inaba or ogawa vibrios . | NA | {
"id": "C0040555",
"name": "toxoid",
"pos": [
31,
37
]
} | {
"id": "C0042210",
"name": "vaccine",
"pos": [
88,
95
]
} |
synergistic protection was observed when toxoid and vaccine were administered together by the oral and parenteral routes . | NA | {
"id": "C0040555",
"name": "toxoid",
"pos": [
41,
47
]
} | {
"id": "C0042210",
"name": "vaccine",
"pos": [
52,
59
]
} |
the nonspecific lymphocyte mitogenicity of purified unlabeled spe c was stimulated by adenosine monophosphate but not adenosine , adenosine diphosphate , or adenosine triphosphate . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
86,
95
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
157,
179
]
} |
furthermore , in vitro suppression of hsv-1 plaque formation in mouse embryo fibroblast cells was obtained by cocultivation of infected fibroblast monolayers with peritoneal macrophages , but not with splenic lymphocytes , from adult mice . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
88,
93
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
136,
146
]
} |
stored data on the inhibition zone diameters of 2274 strains of escherichia coli that had been determined during the first five investigation periods ( 1975 to 1977 ) of the arbeitsgemeinschaft `` '' resistenz '' '' using the standard disc susceptibility test on mueller-hinton agar , were evaluated for : ( 1 ) frequency of secondary resistance to ampicillin , carbenicillin , cephalothin , chloramphenicol , kanamycin , nitrofurantoin , streptomycin , sulfamethoxazole , tetracycline , and trimethoprim-sulfamethoxazole on the basis of statistically defined break points ; | NA | {
"id": "C0038689",
"name": ", sulfamethoxazo",
"pos": [
452,
468
]
} | {
"id": "C0041044",
"name": "trimethoprim-sulfamethoxazo",
"pos": [
492,
519
]
} |
the dissociation constants of rabbit brain phosphorylase , rabbit skeletal muscle phosphorylase a and b and potato glycogen and starch phosphorylases were calculated from the extent of the retardation of mobility as a function of the concentration of the alkyl groups . | NA | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
43,
56
]
} | {
"id": "C0917782",
"name": "starch phosphorylases",
"pos": [
128,
149
]
} |
ion-pair high-performance liquid chromatography : the use of low concentrations of long-chain alkylbenzyldimethylammonium chlorides for resolving anionic solutes . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
0,
3
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
146,
153
]
} |
the qualitative and quantitative determination of large anionic solutes , including the drug sodium cromoglycate , by an ion-pair high-performance liquid chromatographic technique using alkylbenzyldimethylammonium chlorides as pairing ions is described . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
56,
63
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
235,
239
]
} |
amberlite ir-120 , a polystyrene sulphonate type of cation exchanger , equilibrated with a1 3+ ions , has been employed for the fractionation of whole histone . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
52,
58
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
95,
99
]
} |
[ quantitative determination of drugs by in situ spectrophotometry of chromatograms for pharmacokinetic studies . i. sulpiride and other benzamides , vincamine , naftazone ( author 's transl ) ] . | NA | {
"id": "C0038803",
"name": "sulpiride",
"pos": [
117,
126
]
} | {
"id": "C0005029",
"name": "benzamides",
"pos": [
137,
147
]
} |
assays are proposed for sulpiride and other benzamides , vincamine and naftazone in plasma ( or blood ) and urine with direct uv reflectance spectrophotometry on this are applied directly on tlc along with a calibration curve on each plate . | NA | {
"id": "C0038803",
"name": "sulpiride",
"pos": [
24,
33
]
} | {
"id": "C0005029",
"name": "benzamides",
"pos": [
44,
54
]
} |
a strong anion-exchange column coupled to a strong cation-exchange column with acetate buffer as eluent or reversed-phase ion-pair chromatography on octadecylsilica with methanol-water containing 1-heptanesulphonic acid as the mobile phase is described for the simultaneous separation of 5-aminolaevulinic acid and porphobilinogen . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
9,
14
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
281,
284
]
} |
a strong anion-exchange column coupled to a strong cation-exchange column with acetate buffer as eluent or reversed-phase ion-pair chromatography on octadecylsilica with methanol-water containing 1-heptanesulphonic acid as the mobile phase is described for the simultaneous separation of 5-aminolaevulinic acid and porphobilinogen . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
51,
57
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
281,
284
]
} |
it has been applied to the analysis of cannabinoids in human urine obtained from subjects who had smoked delta 9-tetrahydrocannabinol and the identities of some of the cross-reacting cannabinoids have been established by gas chromatography-mass spectrometry . | NA | {
"id": "C0039663",
"name": "delta 9-tetrahydrocannabinol",
"pos": [
105,
133
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
183,
195
]
} |
the excretion , distribution , and metabolism of 2,4-toluenediamine ( tda ) have been compared in rats and mice . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
4,
13
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
35,
45
]
} |
when added to the superfusion medium of rat striatal slices , gaba , glutamate and glycine increased the release of the newly synthetized 3h-da , suggesting that these amino-acids are also directly or indirectly involved in the presynaptic modulation of striatal da release . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
83,
90
]
} | {
"id": "C0002520",
"name": "amino-acids",
"pos": [
168,
179
]
} |
twenty-one ( 46 % ) of 45 patients with acute mitral regurgitation following myocardial infarction and cardiogenic shock operated upon at the pacific medical center died during the early postoperative period . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
77,
98
]
} | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
103,
120
]
} |
cyclic amp derivatives cause the phenomenon of reverse transformation , in which the cell is converted to a fibroblastic morphology with disappearance of the knobs . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
85,
89
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
108,
120
]
} |
3 ) immunofluorescence with antiactin sera reveals condensed , amorphous masses directly beneath the membrane of cb-treated cells instead of smooth , parallel fibrous patterns of reverse-transformed cells or normal fibroblasts ; | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
124,
129
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
215,
226
]
} |
the growth and the fatty acid patterns of the ethanolamine phosphoglyceride and total phosphoglyceride fractions were studied during the first 60 days of life . | NA | {
"id": "C0031618",
"name": "ethanolamine phosphoglyceride",
"pos": [
46,
75
]
} | {
"id": "C0162448",
"name": "phosphoglyceride",
"pos": [
86,
102
]
} |
after weaning , however , animals fed milk protein ( casein ) in the absence of dietary cholesterol became hypercholesterolemic , whereas those fed plant protein ( soy protein isolate ) remained normocholesterolemic . | NA | {
"id": "C0026138",
"name": "milk protein",
"pos": [
38,
50
]
} | {
"id": "C0007332",
"name": "casein",
"pos": [
53,
59
]
} |
all of these problems , classed as technical , include as complications infarction of the graft as the result of prolonged ischemia and blood loss or shock due to various causes , and all may produce alteration in structure of the liver ; | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
72,
82
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
123,
131
]
} |
in spite of the presence of some factors unfavorable for the study of human tumors through xenotransplantation , it has , nevertheless , been clearly shown that the nude mouse/human tumor system is a very useful tool for functional analysis of tumors in relation to growth , differentiation , and morphology , such as eutopic or ectopic production of various hormones , afp , normal serum proteins , colony-stimulating factor , erythropoietin , and so on . | NA | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
400,
425
]
} | {
"id": "C0014822",
"name": "erythropoietin",
"pos": [
428,
442
]
} |
extracts released ura more rapidly and 3meade more slowly from a single-stranded dna than from a double-stranded dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
65,
84
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
97,
116
]
} |
to analyze the structure of the replicating regions of simian virus 40 nucleoprotein complex ( sv40 chromatin ) , photochemical binding of 8-methoxypsoralen ( 8-mop ) and changes in digestability with micrococcal nuclease were studied . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
71,
84
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
100,
109
]
} |
5-hydroxytryptophan ( 5-htp ) but not tryptophan ( tp ) reversed the action of pcpa on the effect of morphine and fentanyl . | NA | {
"id": "C0000578",
"name": "5-htp",
"pos": [
22,
27
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
38,
48
]
} |
these findings confirm that the crucial point in the isp-induced lesions is the increase of calcium inflow , and if the pathogenesis of human myocytolysis is related to catecholamine effects pharmacological measures may be adopted to prevent these myocardial lesions . | NA | {
"id": "C0022245",
"name": "isp",
"pos": [
53,
56
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
169,
182
]
} |
human red blood cells with normal or improved oxygen transport function prepared and frozen in the primary polyvinyl chloride plastic blood collection container . | NA | {
"id": "C0032629",
"name": "polyvinyl",
"pos": [
107,
116
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
126,
133
]
} |
a brain computed tomography -- cisternographic correlation of 48 cases suspected of having normal pressure hydrocephalus ( nph ) was undertaken , observing that the enlargement of temporal horns correlates with abnormal cisternograms compatible with nph , and appears to be a reliable differential feature from cases of cerebral atrophy with `` '' ex-vacuo hydrocephalus '' '' . | NA | {
"id": "C0020258",
"name": "nph",
"pos": [
123,
126
]
} | {
"id": "C0020255",
"name": "hydrocephalu",
"pos": [
107,
119
]
} |
an in vitro test system was used to compare the antimicrobial activity of erythromycin , amoxicillin and ampicillin against respiratory tract pathogens isolated from man . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
89,
100
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
105,
115
]
} |
no significant difference was observed among the declining slopes of post-dosing growth curves for either erythromycin- , amoxicillin- or ampicillin-treated pathogens . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
122,
133
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
138,
148
]
} |
the experimental observations show that the onset of antimicrobial activity and the bactericidal effectiveness of equipotent concentrations of erythromycin , amoxicillin and ampicillin were comparable in this study . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
158,
169
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
174,
184
]
} |
3 ) the fh strain was made resistant to erythromycin , oleandomycin , midecamycin , acetylspiramycin , leucomycin , josamycin , tylosin , lincomycin , or clindamycin by subculture in broth medium from the colony grown at the highest concentrations of each of the antibiotics in agar media . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
138,
148
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
154,
165
]
} |
strains resistant to some of the antibiotics had cross resistance to lincomycin and clindamycin , and strains resistant to others did not . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
69,
79
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
84,
95
]
} |
some strains made resistant to macrolides with cross resistance to lincomycin and clindaymycin and strains made resistant to lincomycin or clindamycin had no cross resistance to vernamycin b alpha , while all the resistant strains without cross resistance to lincomycin and clindamycin had cross resistance to vernamycin b alpha . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
67,
77
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
274,
285
]
} |
[ the use and side effects of chemotherapy in the treatment of malignant bone tumors ( osteosarcoma and ewing 's sarcoma ) ( author 's transl ) ] . | NA | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
87,
99
]
} | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
104,
120
]
} |
urticarial reactions were seen after administration of p-hydroxybenzoic acid methylester ( 5 ) , p-hydroxybenzoic acid propylester ( 6 ) , benzoic acid ( 9 ) , sodium benzoate ( 6 ) , tartrazine ( 6 ) . | NA | {
"id": "C0053225",
"name": "benzoic acid",
"pos": [
64,
76
]
} | {
"id": "C0142805",
"name": "sodium benzoate",
"pos": [
160,
175
]
} |
in contrast to phage lambda the phages t3 , t7 and t4 are not inhibited by as much as 150 microgram bleomycin/ml , while the chemically related antibiotic phleomycin increasingly inhibits the propagation of the phages in the order t4-t3-lambda . | NA | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
100,
109
]
} | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
155,
165
]
} |
from the second to sixth decades of life , obese subjects showed increases in hypercholesterolemia and hyperlipidemia from 2.3 % to 22 % and from 4.6 % to 26 % , respectively . | NA | {
"id": "C0020443",
"name": "hypercholesterolemia",
"pos": [
78,
98
]
} | {
"id": "C0020473",
"name": "hyperlipidemia",
"pos": [
103,
117
]
} |
after transgressing of the pathological process to the state of fibrosis the vessels were showing a striped course presenting a greater number of broncho-pulmonary anastomoses . | NA | {
"id": "C0030660",
"name": "pathological process",
"pos": [
27,
47
]
} | {
"id": "C0016059",
"name": "fibrosis",
"pos": [
64,
72
]
} |
previously only the genetic properties of markers have been considered when choosing the markers to be determined . | NA | {
"id": "C0017393",
"name": "genetic",
"pos": [
20,
27
]
} | {
"id": "C0005516",
"name": "markers",
"pos": [
89,
96
]
} |
the symptoms of thromboembolism in sickle cell anemia patients with acute chest syndromes are difficult to differentiate from the similar symptoms of painful thoracic crises and infectious pulmonary episodes . | NA | {
"id": "C0002895",
"name": "sickle cell anemia",
"pos": [
35,
53
]
} | {
"id": "C0742343",
"name": "acute chest",
"pos": [
68,
79
]
} |
two separate plasminogen activators , differing from kallikrein or prekallikrein , were isolated from the h2so4 lysosomal extract and were partially characterized ; | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
53,
63
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
67,
80
]
} |
it is pointed out that sonography and computer-tomography are now established as newer diagnostic methods , i.e . in distinguishing between cyst and tumor , in renal masses . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
140,
144
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
149,
154
]
} |
[ studies of the regulation potential of glucose metabolism in the calf following infusion of fructose solution and using various hormones ( acth , prednisolone , adrenaline and noradrenaline ) ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
163,
173
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
178,
191
]
} |
the average weight at birth , 1,330 +/- 210 g , and the weight at weaning did not differ from weight figures recorded from the controls . | NA | {
"id": "C0005612",
"name": "weight",
"pos": [
12,
18
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
94,
100
]
} |
development of acetabulum occurred when the transfer had been carried out in children under 1 year of age and was less likely in the older children . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
77,
85
]
} | {
"id": "C1455726",
"name": "older",
"pos": [
133,
138
]
} |
hadjdu-cheney syndrome is a rare type of syndrome characterized by acro-osteolysis , dolichocephaly with multiple wormian bones , absence of frontal sinuses and joint laxity . | NA | {
"id": "C0917715",
"name": "cheney syndrome",
"pos": [
7,
22
]
} | {
"id": "C0917990",
"name": "acro-osteolysis",
"pos": [
67,
82
]
} |
sensitisation of larvae with complement or with antibodies from the serum of immune mice ( resistant to reinfection ) promoted the adherence of mouse peritoneal exudate cells to the larval cuticle during incubation in vitro . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
48,
58
]
} | {
"id": "C0020960",
"name": "serum",
"pos": [
68,
73
]
} |
d-beta-hydroxybutyrate also inhibited the growth of rabbit kidney ( rk13 ) , hela , mouse melanoma ( b16 ) , fibroblast and trypsin-dispersed human thyroid and beef testis cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
109,
119
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
172,
177
]
} |
this finding suggest that endogenous gastrin , stimulated by meat extract , as well as exogenous pentagastrin , influence the secretion of saliva . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
37,
44
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
97,
109
]
} |
alanine and cystine followed by glycine and glutamic acid are the most common amino acids found in the tissues . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
0,
7
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
78,
89
]
} |
alanine and cystine followed by glycine and glutamic acid are the most common amino acids found in the tissues . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
32,
39
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
78,
89
]
} |
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