text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the former residue can only be modified by arginine-directed reagents when the enzyme is activated , i. e. in phosphorylase a , or in phosphorylase b in the presence of activators . | NA | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
110,
123
]
} | {
"id": "C0031711",
"name": "phosphorylase b",
"pos": [
134,
149
]
} |
acute whole body gamma irradiation of the rabbit can induce a latent diabetes revealed by the stimulated hyperglycemia test . | NA | {
"id": "C0271650",
"name": "latent diabetes",
"pos": [
62,
77
]
} | {
"id": "C0020456",
"name": "hyperglycemia",
"pos": [
105,
118
]
} |
in the patients with reflux of bile the cases of antrum gastritis , with diseases of the biliary tract and nonoperated biliary tract diseases were significantly correlated with duodenitis ; | NA | {
"id": "C0005403",
"name": "reflux",
"pos": [
21,
27
]
} | {
"id": "C0005424",
"name": "biliary tract diseases",
"pos": [
119,
141
]
} |
the antidepressant activity of tryptophan and 5-hydroxytryptophan has also been the subject of numerous investigations . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
31,
41
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
46,
65
]
} |
murine pluripotent hematopoietic stem cells and precursor cells with restricted commitment to erythrocytes , granulocytes and macrophages as well as megakaryocytes have been purified 30- to 50-fold from mouse bone marrow cells . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
48,
63
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
221,
226
]
} |
acute intermittent porphyria , urophorphyrinogen 1 synthase , hereditary coproporphyria , coproporphyrinogen oxidase and variegate porphyria , ferrochelatase or protoporphyrinogen oxidase , are the enzymes affected , whilst in the non acute porphyrias , cutaneous hepatic porphyria , uroporphyrinogen decarboxylase , congenital porphyria , uroporphyrinogen cosynthase ; | NA | {
"id": "C0032708",
"name": "porphyrias",
"pos": [
241,
251
]
} | {
"id": "C0162530",
"name": "congenital porphyria",
"pos": [
317,
337
]
} |
prior to synoviorthesis the joint was scanned with technetium ( tc99m ) to compare the inflammation of the synovium with that of six months later . | NA | {
"id": "C0039411",
"name": "technetium",
"pos": [
51,
61
]
} | {
"id": "C0303611",
"name": "tc99m",
"pos": [
64,
69
]
} |
provided that the integrity of the dialyzing membrane is maintained , this investigation indicates that the risk of endotoxemia or bacteremia associated with the use of contaminated dialysis fluids is negligible . | NA | {
"id": "C0376618",
"name": "endotoxemia",
"pos": [
116,
127
]
} | {
"id": "C0004610",
"name": "bacteremia",
"pos": [
131,
141
]
} |
only the diphosphoryl polyisoprenyl derivatives are labeled with udp- ( 14c ) glucosamine and these contain predominantly chitobiose and n-acetylglucosamine itself . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
78,
89
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
137,
156
]
} |
in volunteers with normal renal function , cefaclor produced slightly lower blood levels than those reported for cephalexin . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
43,
51
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
113,
123
]
} |
in contrast to cephalexin , plasma half-life for cefaclor was only moderately prolonged by renal failure ( two-to-threefold ) and only minimally shortened by haemodialysis . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
15,
25
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
49,
57
]
} |
the acute toxicity data for cefaclor in mice , rats , dogs and monkeys were comparable to that previously reported for cephalexin . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
28,
36
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
119,
129
]
} |
on the basis of data from a variety of studies , the useful antibacterial spectrum of cefaclor is shown to include all classes of bacteria that are generally susceptible to cephalothin and cephalexin . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
86,
94
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
189,
199
]
} |
in a cross-over study , 10 healthy adult volunteers received 1 g cefaclor and 1 g cephalexin orally 1 hour after a standard breakfast . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
65,
73
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
82,
92
]
} |
serum levels of cefaclor rose somewhat faster and were higher than those of cephalexin in the first 60 minutes . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
16,
24
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
76,
86
]
} |
the area under the serum level curve averaged 45 hr-micrograms/ml for cefaclor and 60 hr-micrograms/ml for cephalexin . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
70,
78
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
107,
117
]
} |
calculated pharmacokinetic constants indicate that the absorption rate of cefaclor was nearly the same as that of cephalexin . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
74,
82
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
114,
124
]
} |
the urine recovery of cefaclor for 9 hours averaged 65 % , whereas cephalexin resulted in a urine recovery of 85 % . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
22,
30
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
67,
77
]
} |
of the 10 ears from which haemophilus influenzae was isolated , one had a type b strain , and of the remaining unencapsulated strains , one was resistant to both penicillin g and ampicillin . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
162,
174
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
179,
189
]
} |
the effect of gtn and a placebo ointment in prevention of chest pain has been assessed and compared by studying the exercise capacity in 17 patients with angina pectoris . | NA | {
"id": "C0008031",
"name": "in",
"pos": [
33,
35
]
} | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
154,
169
]
} |
does gastrin ( pentagastrin ) act directly on the parietal cell in the isolated whole stomach of the mouse ? | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
5,
12
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
15,
27
]
} |
acid secretion stimulated by pentagastrin was not diminished after pre-treatment with compound 48/80 suggesting that gastrin releases non-mast cell histamine . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
29,
41
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
117,
124
]
} |
some of these virulence factors , such as the alpha toxin , which is phospholipase c , and the kappa toxin , which is a collagenase , are enzymes that hydrolyze substances essential to the integrity of membranes or other body structures . | NA | {
"id": "C1136170",
"name": "virulence factors",
"pos": [
14,
31
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
101,
106
]
} |
other virulence factors , such as the beta , episolon , and iota toxins , act primarily on the vascular endothelium , causing increased capillary permeability , especially in the brain . | NA | {
"id": "C1136170",
"name": "virulence factors",
"pos": [
6,
23
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
65,
71
]
} |
a lipopolysaccharide ( lps ) was found to be chemically distinct from the lps of facultative gram-negative bacteria in that it lacked two core sugars , 2-keto-3-deoxyoctonate and heptose , as well as beta-hydroxymyristic acid , the predominant fatty acid in the lipid a moiety . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
23,
26
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
262,
269
]
} |
b. fragilis and bacteroides melaninogenicus have chemically incomplete lipopolysaccharides as compared with the lipopolysaccharides ( endotoxins ) of aerobic bacteria , and the lipopolysaccharides of bacteroides lack the biologic potency characteristic of endotoxin . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
71,
90
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
256,
265
]
} |
[ epilepsy in the third age : seizures presenting after the age of 60 years ( author 's transl ) ] . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
2,
10
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
30,
38
]
} |
proteins which potentiate the conversion of prekallikrein to kallikrein by hageman factor fragments are present in cryoprecipitate prepared from the plasma of an individual lacking hmw kininogen as well as in purified von willebrand 's factor preparations . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
44,
57
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
61,
71
]
} |
a new function for ceruloplasmin as an acute-phase reactant in inflammation : a scavenger of superoxide anion radicals . | NA | {
"id": "C0007841",
"name": "ceruloplasmin",
"pos": [
19,
32
]
} | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
39,
59
]
} |
thus , we can only speculate that under conditions where levels of ceruloplasmin are markedly elevated , as during pregnancy , during acute infections , or in association with inflammatory diseases ( such as rheumatoid arthritis ) , this acute-phase reactant may play a major role as a circulating scavenger of oxygen-derived free radicals . | NA | {
"id": "C0007841",
"name": "ceruloplasmin",
"pos": [
67,
80
]
} | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
238,
258
]
} |
the alcaline phosphatase of cattle and sheep liver , spleen , kidney , lung , bone and placenta was thermo-labile and sensitive to l-arginine , l-homoarginine and imidazole , but was not sensitive to l-phenylalanine . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
133,
141
]
} | {
"id": "C0019877",
"name": "homoarginine",
"pos": [
146,
158
]
} |
intestinal phosphatase of cattle proved thermostable , sensitive to l-phenylalanine and not sensitive to l-arginine , l-homoarginine , imidasol and urea . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
107,
115
]
} | {
"id": "C0019877",
"name": "homoarginine",
"pos": [
120,
132
]
} |
t3 administration caused almost no change in aortic total and all lipid fractions in male rats kept on diets containing any of the fats used . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
66,
71
]
} | {
"id": "C0015677",
"name": "fats",
"pos": [
131,
135
]
} |
the angiopathic findings are characterized by the enrichment of activity in the marginal seam as a sign of hyperemia and decreased accumulation in the centre as an expression of necrobiosis . | NA | {
"id": "C0042373",
"name": "angiopathic",
"pos": [
4,
15
]
} | {
"id": "C0020452",
"name": "hyperemia",
"pos": [
107,
116
]
} |
a possible explanation for this could be the fact that relatively small amounts of the inhaled virus antigen developed antigenic activity on the mucous membrane . | NA | {
"id": "C0003342",
"name": "virus antigen",
"pos": [
95,
108
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
119,
128
]
} |
the corrosion products consisted of calcium , phosphorous , iron , chromium , nickel , zinc , stannum and other elements . | NA | {
"id": "C0031705",
"name": "phosphorous",
"pos": [
46,
57
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
112,
120
]
} |
rarely , extramammary paget 's disease results from direct extension into the skin of an adenocarcinoma in a contiguous organ such as the genitourinary or gastrointestinal tract . | NA | {
"id": "C0030186",
"name": "extramammary paget 's disease",
"pos": [
9,
38
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
89,
103
]
} |
an indirect immunoenzymatic test using immobilized lectins ( concanavalin a , phytohaemagglutinin els , wheat germ agglutinin , recin types i and ii , peanut agglutinin ) gave some light on the carbohydrate composition of the carrier molecules , whereas the amino acid part of these molecules seemed to indicate an unique oligopeptide , the composition of which would be : asx ( 4 ) , thr ( 2 ) , ser ( 4 ) , glux ( 6 ) , gly ( 6 ) ala ( 3 ) , val ( 2 ) , ile ( 1 ) , leu ( 2 ) , phe ( 8 ) , lys ( 2 ) , arg ( 1 ) . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
258,
268
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
422,
425
]
} |
this enhancement of response appeared to be produced by more efficient recruitment of precursor cells as demonstrated by an increased frequency of antibody-forming cells in an in vivo limiting dilution technique . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
86,
101
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
164,
169
]
} |
the aim of the paper was to study the effect of benzylpenicillin , cloxacillin and ampicillin in combination with streptomycin , kanamycin and gentamicin on antibiotic-resistant strains of streptococcus group d . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
48,
64
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
83,
93
]
} |
morphological studies of the heart muscle were carried out in healthy rats as well as treated with hydralazine or binazine after administration of adrenaline , noradrenaline , isoprenaline , regitine or propranolol . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
147,
157
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
160,
173
]
} |
evident changes ( e.g . inflammatory infiltrations , focal necrosis and fibrosis ) were found after administration of noradrenaline , adrenaline or isoprenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
118,
131
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
134,
144
]
} |
blood glucose was high , the protein picture was altered with a los of albumin , and infection was present . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
29,
36
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
71,
78
]
} |
[ dyskinetic-athetosic syndrome in a patient with prior radiculo-myelo-encephalopathy of probable viral origin . therapeutic guidelines with levodopa and preliminary results ] . | NA | {
"id": "C0013384",
"name": "dyskinetic",
"pos": [
2,
12
]
} | {
"id": "C0004158",
"name": "athetosic",
"pos": [
13,
22
]
} |
throughouth lactation , galactose was the predominant monosaccharide constituent of acid hydrolysates of the milk carbohydrate . | NA | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
54,
68
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
114,
126
]
} |
in two animals which suckled both a new-born pouch young and a young at foot , the mammary gland supplying the new-born secreted milk which was rich in oligosaccharides , whereas that supplying the young at foot produced milk in which the carbohydrates were mainly free monosaccharides , and which had a much lower carbohydrate content . | NA | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
270,
285
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
315,
327
]
} |
electron microscopy and analytical and preparative ultracentrifugation showed that lymph lipoproteins from sheep and lambs fed low fat diets consisted mainly of lipoproteins 50 nm in diameter and that very low density lipoproteins ( sf 20 -- 400 ) contirbuted up to 75 % of the sf greater than 20 lipoproteins . | NA | {
"id": "C0023825",
"name": "very low",
"pos": [
201,
209
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
297,
309
]
} |
the maximum contribution of very low density lipoproteins ( sf 20 -- 400 ) to lipoproteins of sf greater than 20 was 27 -- 30 % . | NA | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
28,
57
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
78,
90
]
} |
the biosynthesis of collagen measured by the rate of [ 14c ] hydroxyproline formation and the activity of proline , 2-oxoglutarate dioxygenase ( ec 1.14.11.2. formerly prolyl hydroxylase ) was reduced during the first half of treatment to a greater extent than the rate of [ 14c ] proline incorporation into proteins . | NA | {
"id": "C0599874",
"name": "dioxygenase",
"pos": [
131,
142
]
} | {
"id": "C3665675",
"name": "prolyl hydroxylase",
"pos": [
168,
186
]
} |
no virus production or changes in morphology were induced in these cells by budr , deoxyuridine ( udr ) , 5-fluorodeoxyuridine ( fudr ) or thymidine ( tdr ) . | NA | {
"id": "C0006233",
"name": "budr",
"pos": [
76,
80
]
} | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
114,
126
]
} |
the maximum increase and the area of increase were examined both for blood glucose and plasma i.r.i. , and the corresponding i.r.i./glucose ratios calculated . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
69,
82
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
132,
139
]
} |
the present experiments on melittin and preliminary results with other polypeptides and proteins demonstrate that in favourable cases high-resolution 1h nmr studies of the complexes formed between membrane proteins and deuterated micelles provides a viable method for conformational studies of membrane-bound proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
88,
96
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
197,
214
]
} |
the residual particulate protein is enriched in hydropholic amino acids and presumably contains the portion of membrane-bound proteins which are in direct contact with the bilayer . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
25,
32
]
} | {
"id": "C0025252",
"name": "membrane",
"pos": [
111,
119
]
} |
guinea-pig taenia coli strips that had been incubated with [ 3h ] arachidonic acid , constantly released [ 3h ] arachidonic acid and [ 3h ] prostaglandin e and a prostaglandin which cochromatographed with prostaglandin e but could not be converted to prostaglandin b by alkali and was shown to be 6-ketoprostaglandin f1 alpha . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
140,
153
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
205,
220
]
} |
guinea-pig taenia coli strips that had been incubated with [ 3h ] arachidonic acid , constantly released [ 3h ] arachidonic acid and [ 3h ] prostaglandin e and a prostaglandin which cochromatographed with prostaglandin e but could not be converted to prostaglandin b by alkali and was shown to be 6-ketoprostaglandin f1 alpha . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
140,
153
]
} | {
"id": "C0033557",
"name": "prostaglandin b",
"pos": [
251,
266
]
} |
labelling experiments , designed to determine the temporal sequence of appearance of n-acetylglucosamine in intracellular free sugar and sugar-phosphate pools , indicated that n-acetylglucosamine first appeared in the cells as pohosphorylated form . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
127,
132
]
} | {
"id": "C0038655",
"name": "sugar-phosphate",
"pos": [
137,
152
]
} |
furthermore , inhibitors of energy metabolism ( arsenate , azide and cyanide ) , proton conductor ( m-chlorocarbonylcyanide phenylhydrazine ) and dibenzyl diammonium ion ( membrane permeable cation ) inhibited the inducible n-acetylglucosamine uptake in c. albicans . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
166,
169
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
191,
197
]
} |
in addition , partition coefficients for n-octanol between n-hexadecane and 0.1 m nacl , dielectric constants for octanol-hexadecane mixtures and the interfacial tension of films and film-forming lipid solutions against the aqueous phases have been determined . | NA | {
"id": "C0044551",
"name": "n-octanol",
"pos": [
41,
50
]
} | {
"id": "C0001979",
"name": "octanol",
"pos": [
114,
121
]
} |
binding curves for the contact contribution ( f curves ) were obtained from vesicles in solutions of sodium salts with monovalent anions over a wide concentration range . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
15,
16
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
130,
136
]
} |
comparison of results with lanthanide ions and ca2+ indicates that the anion adsorption probably depends on the nature of the adsorbed cation . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
38,
42
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
71,
76
]
} |
comparison of results with lanthanide ions and ca2+ indicates that the anion adsorption probably depends on the nature of the adsorbed cation . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
38,
42
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
135,
141
]
} |
from these studies we conclude that the exchange protein is a useful method to alter the phospholipid composition of vldl under conditions such that there is minimal perturbation of the lipoprotein . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
117,
121
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
186,
197
]
} |
[ studies on the mechanism of hypertrophic action of hydrocortisone on secretory tubules of the mouse submandibular gland . ( 1 ) interaction of hydrocortisone acetate with cyproterone acetate ( author 's transl ) ] . | NA | {
"id": "C0020268",
"name": "hydrocortisone",
"pos": [
53,
67
]
} | {
"id": "C0063077",
"name": "hydrocortisone",
"pos": [
145,
159
]
} |
[ studies on the mechanism of the hypertrophic action of hydrocortisone on the secretory tubules of the mouse submandibular gland . ( 2 ) the action of hydrocortisone acetate on the secretory tubules of the tfm mouse ( author 's transl ) ] . | NA | {
"id": "C0020268",
"name": "hydrocortisone",
"pos": [
57,
71
]
} | {
"id": "C0063077",
"name": "hydrocortisone acetate",
"pos": [
152,
174
]
} |
the biggest changes occur in the branched-chain amino acids valine , isoleucine and leucine which are markedly decreased . | NA | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
33,
59
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
60,
66
]
} |
the biggest changes occur in the branched-chain amino acids valine , isoleucine and leucine which are markedly decreased . | NA | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
33,
59
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
69,
79
]
} |
the biggest changes occur in the branched-chain amino acids valine , isoleucine and leucine which are markedly decreased . | NA | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
33,
59
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
84,
91
]
} |
exposure of male wistar rats to 12.3 mumol/l ( 300 ppm ) isopropanol vapour for 5-21 weeks , 5 days a week for 6 h daily with a simultaneous ethanol administration in drinking water ( 5 % v/v ) caused a significant increase in isopropanol removal as assessed by blood isopropanol and acetone determinations . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
141,
148
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
268,
279
]
} |
analyses of spinal cord axon lipid composition showed increases in cholesterol content in relation to lipid phosphorus in animals exposed to isopropanol or to the isopropanol and ethanol combination . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
141,
152
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
179,
186
]
} |
behavioural tests indicated minor effects on emotional reactivity from the 10th week onwards with isopropanol exposure whereas caffeine-stimulated activity was augmented only in rats ingesting ethanol . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
98,
109
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
193,
200
]
} |
as phenylethylbiguanide at different inactivation rates does not show any mutagenic effect , the biguanide structure does not seem to be responsible for chemical mutagenesis . | NA | {
"id": "C0031404",
"name": "phenylethylbiguanide",
"pos": [
3,
23
]
} | {
"id": "C0005382",
"name": "biguanide",
"pos": [
97,
106
]
} |
the assay was tested with simple epoxides : propylene oxide , glycidol , epichlorohydrin , trichloropropylene oxide and styrene oxide , which are known to vary considerably in their mutagenic potency . | NA | {
"id": "C0014630",
"name": "epoxides",
"pos": [
33,
41
]
} | {
"id": "C0014486",
"name": "epichlorohydrin",
"pos": [
73,
88
]
} |
the assay was tested with simple epoxides : propylene oxide , glycidol , epichlorohydrin , trichloropropylene oxide and styrene oxide , which are known to vary considerably in their mutagenic potency . | NA | {
"id": "C0014630",
"name": "epoxides",
"pos": [
33,
41
]
} | {
"id": "C0040903",
"name": "trichloropropylene oxide",
"pos": [
91,
115
]
} |
a summary scheme is given for the metabolism of glutathione in which glutathione is translocated to the cell membrane where it may be utilized as such or oxidized to glutathione disulphide . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
48,
59
]
} | {
"id": "C0061516",
"name": "oxidized",
"pos": [
154,
162
]
} |
sulphatase a was first described as an arylsulphatase but was subsequently shown to have cerebroside sulphatase activity , bydrolysing galactose 3-sulphate residues in certain lipids . | NA | {
"id": "C0038717",
"name": "sulphatase",
"pos": [
0,
10
]
} | {
"id": "C0003940",
"name": "arylsulphatase",
"pos": [
39,
53
]
} |
preliminary data suggest that unlike thiol : protein-disulphide oxidoreductase , protein-disulphide isomerase , or gssg/gsh redox systems , sulphydryl oxidase does not permit a 'reshuffling ' of disulphide bonds . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
115,
119
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
120,
123
]
} |
a small contamination of transferrin in the human serum albumin preparations used was shown to be responsible for their growth-supporting effect , while no need for the presence of albumin itself could be demonstrated . | NA | {
"id": "C0304925",
"name": "human serum albumin preparations",
"pos": [
44,
76
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
181,
188
]
} |
angiotensin ii blockade was achieved by continuous infusion of sar1-ile5-leu8-angiotensin ii ( saralasin ) , a competitive inhibitor of angiotensin ii . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
0,
14
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
95,
104
]
} |
the duration of ethanol-induced narcosis was significantly shorter and blood ethanol concentration at the moment of righting reflex recovery was higher in pyrithiamin-treated rats than in controls . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
16,
23
]
} | {
"id": "C0684262",
"name": "blood ethanol",
"pos": [
71,
84
]
} |
the substrate specificity of the enzymes , enzymes in the immobilized state , and the application of proton and 13c nmr for structure determination of reaction products are reviewed . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
33,
40
]
} | {
"id": "C0014444",
"name": "enzymes",
"pos": [
43,
50
]
} |
this work describes the development of useful synthetic methodology with simple sugars , practical applications for conversion of abundant precursors into modified sugars ( especially amino and deoxy sugars ) of importance in various groups of natural products , and the conversion of such products into compounds of biological or pharmacological interest , especially carbohydrate antibiotics and their analogs . | NA | {
"id": "C0026492",
"name": "simple",
"pos": [
73,
79
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
369,
381
]
} |
this work describes the development of useful synthetic methodology with simple sugars , practical applications for conversion of abundant precursors into modified sugars ( especially amino and deoxy sugars ) of importance in various groups of natural products , and the conversion of such products into compounds of biological or pharmacological interest , especially carbohydrate antibiotics and their analogs . | NA | {
"id": "C0011471",
"name": "deoxy sugars",
"pos": [
194,
206
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
369,
381
]
} |
malabsorption of lipides causes steatorrhoea and is often associated with choleriform diarrhoea owing to the massive losses of water and electrolytes ( na , cl , ca , mg ) . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
0,
13
]
} | {
"id": "C0038238",
"name": "steatorrhoea",
"pos": [
32,
44
]
} |
during incubation of antipyrine , but not amidopyrine , 4-aminoantipyrine and 4-leucylaminoantipyrine , with rat liver microsomaland cytosol fractions in the presence of nadph-generating system a reactive metabolite , which binds with glutathione is formed . | NA | {
"id": "C0002586",
"name": "amidopyrine",
"pos": [
42,
53
]
} | {
"id": "C0002696",
"name": "4-aminoantipyrine",
"pos": [
56,
73
]
} |
our results suggest that indomethacin may act to inhibit the prostaglandin endoperoxide synthetase enzyme by complexing fe++ in the enzyme . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
99,
105
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
132,
138
]
} |
the improved survival was accompanied by a diminished plasma accumulation of the cardiotoxic peptide , myocardial depressant factor ( mdf ) , and the lysosomal protease cathepsin d . | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
93,
100
]
} | {
"id": "C0027047",
"name": "myocardial depressant factor",
"pos": [
103,
131
]
} |
higher doses of prostaglandin e2 induce additional electrolyte alterations which may result from modified gut transport of water and ions . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
51,
62
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
133,
137
]
} |
the significant drop in progesterone ( delta 4p ) but rise in 20 alpha-dihydroprogesterone ( 20 alpha-dhp ) occurred 24 hr after treatment in psp rats treated with both-end open silastic-pvp-pgf2 alpha tube , whereas similar changes in delta 4p and 20 alpha-dhp took place 48-72 hr after the deposition of a one-end open silastic-pvp pgf2 alpha tube . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
24,
36
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
62,
90
]
} |
the syndrome is the clinical expression of the lymphochronic variety of the toxoplasmic disease in the child and it is clinically expressed by the triad : dystrophies , psychiatric disorders and adenopathies with a chronic course . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
4,
12
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
88,
95
]
} |
[ bacteriuria , urinary infection and pyelonephritis : critical analysis of the results obtained during the years 1958-1978 . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
2,
13
]
} | {
"id": "C0042029",
"name": "urinary infection",
"pos": [
16,
33
]
} |
a preliminary series of experiments indicated that ascorbic acid and calcium and sodium ascorbate in the absence of serum had no stimulatory effect on neutrophil motility . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
51,
64
]
} | {
"id": "C0887557",
"name": "sodium ascorbate",
"pos": [
81,
97
]
} |
it is suggested that the enhanced neutrophil motility mediated by ascorbic acid and calcium and sodium ascorbate in the presence of serum may be due to increased cgmp and/or glycolysis . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
66,
79
]
} | {
"id": "C0887557",
"name": "sodium ascorbate",
"pos": [
96,
112
]
} |
effects of ascorbic acid and calcium and sodium ascorbate on neutrophil phagocytosis and post-phagocytic metabolic activity . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
11,
24
]
} | {
"id": "C0887557",
"name": "sodium ascorbate",
"pos": [
41,
57
]
} |
the effects of ascorbic acid and calcium and sodium ascorbate at a concentration range of 10 ( -6 ) m - 10 ( -1 ) m on polymorphonuclear leucocyte ( pmn ) phagocytosis of candida albicans and post-phagocytic nitroblue tetrazolium ( nbt ) reduction , hexose monophosphate shunt ( hms ) activity and myeloperoxidase-mediated iodination of ingested protein were investigated . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
15,
28
]
} | {
"id": "C0887557",
"name": "sodium ascorbate",
"pos": [
45,
61
]
} |
concentrations of ascorbic acid and calcium and sodium ascorbate which caused inhibition of phagocytosis and hms activity were the same as those which mediated stimulation of cell motility , indicating that independent cellular mechanisms may govern motility and phagocytosis . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
18,
31
]
} | {
"id": "C0887557",
"name": "sodium ascorbate",
"pos": [
48,
64
]
} |
the causes of death in order of frequency were : malignant disease of the cervix ( 30 % ) , malignant disease of the ovary ( 17 % ) , incomplete abortion ( 15 % ) , non-gynaecological conditions ( 11 % ) , malignant disease of the corpus uteri ( 8 % ) , intra-abdominal malignancy ( 6 % ) , pulmonary embolism ( 3 % ) , sepsis not associated with abortion ( 3 % ) , malignant disease of the vulva ( 2 % ) , and other conditions ( 5 % ) . | NA | {
"id": "C0017411",
"name": "gynaecological conditions",
"pos": [
169,
194
]
} | {
"id": "C0042131",
"name": "disease of",
"pos": [
376,
386
]
} |
the causes of death in order of frequency were : malignant disease of the cervix ( 30 % ) , malignant disease of the ovary ( 17 % ) , incomplete abortion ( 15 % ) , non-gynaecological conditions ( 11 % ) , malignant disease of the corpus uteri ( 8 % ) , intra-abdominal malignancy ( 6 % ) , pulmonary embolism ( 3 % ) , sepsis not associated with abortion ( 3 % ) , malignant disease of the vulva ( 2 % ) , and other conditions ( 5 % ) . | NA | {
"id": "C0017411",
"name": "gynaecological conditions",
"pos": [
169,
194
]
} | {
"id": "C0042994",
"name": "disease of",
"pos": [
376,
386
]
} |
the pharmacokinetic principles underlying modern drug treatment of epileptic seizures are discussed and the drug ( s ) of choice for different seizure types are listed according to their clinical efficacy . | NA | {
"id": "C0014544",
"name": "epileptic seizures",
"pos": [
67,
85
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
143,
150
]
} |
indications in the literature that these findings may apply to human beings suggest that in some situations atrial fibrillation may be better controlled with a hydrophilic digitalis preparation ( e.g . ouabain ) , whereas cardiac failure with a tendency to atrioventricular block may be better controlled with a lipophilic preparation ( e.g . digitoxin ) . | NA | {
"id": "C0304520",
"name": "digitalis preparation",
"pos": [
172,
193
]
} | {
"id": "C0012258",
"name": "digitoxin",
"pos": [
343,
352
]
} |
in non-whites stillbirths accounted for more than two-thirds of perinatal deaths in 1977 , and in at least 75 % of these fetal death preceded labour . | NA | {
"id": "C0595939",
"name": "stillbirths",
"pos": [
14,
25
]
} | {
"id": "C0015927",
"name": "fetal death",
"pos": [
121,
132
]
} |
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