text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
all patients considered for regular haemodialysis , as well as all nurses recruited to work in the haemodialysis unit of baragwanath hospital , were tested for the presence of hepatitis-associated antigen ( hbag ) and for antibody to hepatitis-associated antigen ( hbab ) . | NA | {
"id": "C0019165",
"name": "hbag",
"pos": [
207,
211
]
} | {
"id": "C0019168",
"name": "hepatitis-associated antigen",
"pos": [
234,
262
]
} |
effects of the sulphonylurea drugs gliclazide and glibenclamide on blood glucose control and platelet function . | NA | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
15,
28
]
} | {
"id": "C0017631",
"name": "gliclazide",
"pos": [
35,
45
]
} |
effects of the sulphonylurea drugs gliclazide and glibenclamide on blood glucose control and platelet function . | NA | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
15,
28
]
} | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
50,
63
]
} |
the patients had the following lung diseases : infectious pneumonitis ( 19 cases ) , pulmonary fibrosis ( 13 cases ) including 5 sarcoidosis , 3 idiopathic pulmonary fibrosis and 5 silicosis , hypersensitivity pneumonitis ( 5 cases ) and miscellaneous lung tumors ( 12 cases ) . | NA | {
"id": "C0024115",
"name": "lung diseases",
"pos": [
31,
44
]
} | {
"id": "C0034069",
"name": "pulmonary fibrosis",
"pos": [
156,
174
]
} |
labelled amino acids , 14c-leucine , 3h-glycine , 14c-gaba , 14c-glutamic acid and 14c-aspartic acid were applied to the surface of the cat 's auditory cortex in dried filter paper strips for 40 min . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
9,
20
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
40,
47
]
} |
comparison of results obtained showed that the technique based on the ratio between the two radioisotopes overestimates intestinal absorption by about 9 % with respect to values calculated with the deconvolution method , but gives results comparable to those determined by oral administration of the isotope . | NA | {
"id": "C0034595",
"name": "radioisotopes",
"pos": [
92,
105
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
300,
307
]
} |
previous observations from this laboratory suggest that chlorpropamide and phenformin , two hypoglycemic drugs belonging to sulfonylureas and biguanides respectively , act on liver plasma membranes altering the activity of enzymes bound to plasma membrane as ( na+-k+ ) -atpase . | NA | {
"id": "C0008287",
"name": "chlorpropamide",
"pos": [
56,
70
]
} | {
"id": "C0038766",
"name": "sulfonylureas",
"pos": [
124,
137
]
} |
previous observations from this laboratory suggest that chlorpropamide and phenformin , two hypoglycemic drugs belonging to sulfonylureas and biguanides respectively , act on liver plasma membranes altering the activity of enzymes bound to plasma membrane as ( na+-k+ ) -atpase . | NA | {
"id": "C0031404",
"name": "phenformin",
"pos": [
75,
85
]
} | {
"id": "C0005382",
"name": "biguanides",
"pos": [
142,
152
]
} |
one antisera contained antibodies against both the nh2 region and the cooh terminal of the molecule ( antiserum 211/32 , wellcome laboratories ) , the other contained antibodies against antigenic sites of the terminal cooh portion ( immuno nuclear corporation antiserum ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
23,
33
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
260,
269
]
} |
the mean mobility of the resident macrophages decreased approximately 60 % when incubated in the presence of immune complexes , although no effect could be discerned in the presence of antigen or antibody alone . | NA | {
"id": "C0003313",
"name": "immune",
"pos": [
109,
115
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
196,
204
]
} |
this test was found to be useful in diagnosing epileptic seizures in patients in whom both the history and diurnal eeg studies were unhelpful , and it assisted with the accurate classification of seizure types . | NA | {
"id": "C0014544",
"name": "epileptic seizures",
"pos": [
47,
65
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
196,
203
]
} |
diffusion of antigen from its site and loss of antigenic determinants due to procedures for preserving morphology are two other main problems . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
13,
20
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
47,
69
]
} |
the drug treatment of epilepsy poses considerable problems , including the high prevalence and early age of onset of seizures , the relatively poor prognosis in many patients , prolonged polypharmacy , chronic toxicity , and uncertainty of the relative efficacy of individual drugs . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
22,
30
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
117,
125
]
} |
to test whether central neurogenic factors participate in blood pressure elevation in primary hypertension , we studied the concentrations of : norepinephrine , epinephrine and dopamine-beta-hydroxylase ( dbh ) in cerebrospinal fluid ( csf ) ; | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
144,
158
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
161,
172
]
} |
and norepinephrine , epinephrine , dbh and plasma renin activity ( pra ) in plasma of 22 subjects ( seven with primary hypertension , 11 normotensive patients with non-systemic neurological disorders , and four with secondary hypertension ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
4,
18
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
21,
32
]
} |
the low csf norepinephrine and epinephrine , despite markedly increased plasma ne and epinephrine , in two patients with pheochromocytoma , indicate a blood-brain barrier for these neurohormones . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
18,
20
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
86,
97
]
} |
purified peptidyl dipeptidase ( angiotensin i converting enzyme or kininase ii ) from human lung or hog kidney is inhibited by commercially prepared plasma protein preparations , by human serum albumin and by the additive albumin stabilizer , acetyltryptophan . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
182,
201
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
222,
229
]
} |
cefaclor is the most active antibiotic against strains of haemophilus influenzae , and is also more active than cephalexin and cephradine against non-beta-lactamase producing strains of escherichia coli , klebsiella species and proteus mirabilis . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
0,
8
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
112,
122
]
} |
cefaclor is the most active antibiotic against strains of haemophilus influenzae , and is also more active than cephalexin and cephradine against non-beta-lactamase producing strains of escherichia coli , klebsiella species and proteus mirabilis . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
112,
122
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
127,
137
]
} |
the antibacterial activity of cefaclor against 100 non-beta-lactamase producing and 11 beta-lactamase producing isolates of haemophilus influenzae was compared with that of cephalexin , ampicillin , chloramphenicol , tetracycline and co-trimoxazole . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
30,
38
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
173,
183
]
} |
a comparison of the minimal inhibitory concentrations ( mic ) of cefaclor and cephalexin shows that cefaclor is noticeably superior against citrobacter . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
78,
88
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
100,
108
]
} |
in order to compare the activity of cefaclor and cephalexin , the effect of subinhibitory concentrations of both antibiotics against escherichia coli and klebsiella pneumoniae strains was studied by means of turbidimetry . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
36,
44
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
49,
59
]
} |
after eight hours the absolute inhibitory concentration of cefaclor was lower than that of cephalexin with both methods . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
59,
67
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
91,
101
]
} |
automatic measurement over 20 hours showed at the end of the experiment a higher mic , and also a higher subinhibitory range , for cefaclor than for cephalexin . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
131,
139
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
149,
159
]
} |
in our opinion the absolute inhibitory concentration after eight hours should be the criterion used to evaluate the effectiveness of cefaclor and cephalexin , and not the mic which is usually used . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
133,
141
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
146,
156
]
} |
a comparison was made with the efficacy of oxacillin , azlocillin , amikacin , gentamicin , ampicillin , co-trimoxazole , tetracycline , penicillin , cefazolin , nalidixic acid and nitrofurantoin . | NA | {
"id": "C0004499",
"name": "azlocillin",
"pos": [
55,
65
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
92,
102
]
} |
the in vitro activity of cephradine , cephalexin , and cefaclor was studied in comparison with that of cephalothin . | NA | {
"id": "C0007738",
"name": "cephradine",
"pos": [
25,
35
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
38,
48
]
} |
the in vitro activity of cephradine , cephalexin , and cefaclor was studied in comparison with that of cephalothin . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
38,
48
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
55,
63
]
} |
on the basis of data from a variety of studies , the useful antibacterial spectrum of cefaclor is shown to include all classes of bacteria that are generally susceptible to cephalothin and cephalexin . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
86,
94
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
189,
199
]
} |
of decisive importance for the detection of uti is an appropriate investigation to determine whether there is significant bacteriuria . | NA | {
"id": "C0042029",
"name": "of",
"pos": [
0,
2
]
} | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
122,
133
]
} |
in neonates , boys are more frequently affected than girls , whereas in older age-groups the incidence of significant bacteriuria ( approximately 1.5 % ) and clinically relevant uti or pyelonephritis is higher in females than in males . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
118,
129
]
} | {
"id": "C0042029",
"name": "uti",
"pos": [
178,
181
]
} |
humoral-cellular antibodies and the complement system play a role in phagocytosis , acting as phagocytosis-enhancing agents ( opsonins ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
17,
27
]
} | {
"id": "C0029122",
"name": "opsonins",
"pos": [
126,
134
]
} |
two pregnancy-associated proteins reacting with antibody against pregnancy-specific beta 1-glycoprotein ( ps beta g or sp1 ) were separated by means of ammonium sulphate precipitation , size chromatography and preparative zone electrophoresis . | NA | {
"id": "C0032974",
"name": "pregnancy",
"pos": [
4,
13
]
} | {
"id": "C0033002",
"name": "pregnancy-specific beta 1-glycoprotein",
"pos": [
65,
103
]
} |
the alpha-1 acid glycoprotein ( orosomucoid ; aag ) is a normal constituent of human plasma ( 650+/-215 microgram ml ( -1 ) ) which increases in concentration as much as fivefold in associations with acute inflammation and cancer , and thus is recognized as an acute phase protein . | NA | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
32,
43
]
} | {
"id": "C0001347",
"name": "acute phase protein",
"pos": [
261,
280
]
} |
antibiotic-induced muscle paralysis has frequently been found in both experimental animals and man with three distinct classes of antibiotic : ( 1 ) streptomycin and related aminoglycoside compounds , ( 2 ) polymyxins and ( 3 ) tetracyclines . | NA | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
149,
161
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
174,
188
]
} |
recently lincomycin and its chemical congener , clindamycin , have been reported to produce muscle paralysis which has different characteristics from those seen with other classes of antibiotic . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
9,
19
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
48,
59
]
} |
although closely related in chemical structure , lincomycin and clindamycin also seem to produce muscle paralysis by different mechanisms . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
49,
59
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
64,
75
]
} |
clindamycin is considered to exert a direct depressant action on muscle contractility whereas the action of lincomycin is considered to be primarily a depression of neuromuscular transmission . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
0,
11
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
108,
118
]
} |
the naturally occurring phorbol esters such as 12-o-tetradecanoyl phorbol-13-acetate ( tpa ) are potent tumour promoting agents . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
24,
38
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
66,
73
]
} |
we have previously demonstrated in these fibroblasts abnormal phenotypic expressions which often appear in transformed cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
41,
52
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
119,
124
]
} |
we now report studies on the membrane gp composition and the t-transferase activity of platelets isolated from there tn-syndrome patients whose red cell membranes contain gp abnormalities which are typical of those found in this rare clinical condition . | NA | {
"id": "C0025248",
"name": "membrane gp",
"pos": [
29,
40
]
} | {
"id": "C0017968",
"name": "gp",
"pos": [
171,
173
]
} |
factors affecting the bluetongue virus neutralizing antibody response and the reaction between virus and antibody . | NA | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
39,
60
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
105,
113
]
} |
a study was made of different aspects of the bluetongue virus neutralizing antibody response and the reaction between the virus and antibody . | NA | {
"id": "C0475463",
"name": "neutralizing",
"pos": [
62,
74
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
132,
140
]
} |
some of the dark cells may represent cells undergoing regressive alterations , but the majority of them seem to represent chondroblasts with imperfect maturation towards chondrocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
17,
22
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
170,
182
]
} |
efflux of lithium from human erythrocytes was studied in patients before , during , and after discontinuation of administration of lithium carbonate . | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
10,
17
]
} | {
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
131,
148
]
} |
media must be supplemented with either pyridoxal hydrochloride or pyridoxamine dihydrochloride ( the active forms of vitamin b6 ) for isolation , identification , and subsequent testing of susceptibility to antimirobial agents . | NA | {
"id": "C0034263",
"name": "pyridoxal",
"pos": [
39,
48
]
} | {
"id": "C0087162",
"name": "vitamin b6",
"pos": [
117,
127
]
} |
it is not clear at present whether the nuclear antigen is a viral protein or a cell protein induced by the epstein-barr virus as a result of polyclonal b cell activation . | NA | {
"id": "C0042736",
"name": "viral protein",
"pos": [
60,
73
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
84,
91
]
} |
in severe pigbel prolonged starvation may result in malnutrition that impairs wound healing and increases mortality . | NA | {
"id": "C0038187",
"name": "starvation",
"pos": [
27,
37
]
} | {
"id": "C0162429",
"name": "malnutrition",
"pos": [
52,
64
]
} |
at a high pressure the culture possesses the ability for extracellular accumulation of free keto and amino acids , pyruvic , alpha-ketoglutaric , and oxaloacetic acids , alanine , and glutamic acid , while under conditions of atmospheric pressure , chiefly valine is accumulated in the medium , and there are no extracellular keto acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
101,
112
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
170,
177
]
} |
a reevaluation of the role of cytochrome p-450 as the terminal oxidase in hepatic microsomal mixed function oxidase catalyzed reactions . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
30,
46
]
} | {
"id": "C0003927",
"name": "oxidase",
"pos": [
108,
115
]
} |
whilst all of the antisera had considerable activity for mouse spermatozoa , none of them was found to contain antibodies specific for t/t region gene products . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
18,
26
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
111,
121
]
} |
pre-incubation experiments indicate that the maternal serum has a protective action on the embryonic cells which is largely specific for the female 's own embryos ( and suggested to be antibody in nature ) and an inhibitory action on the maternal spleen cells which occurs also with spleen cells of other females ( and suggested to be either an immune complex or a nonimmunological substances ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
185,
193
]
} | {
"id": "C0003313",
"name": "immune complex",
"pos": [
345,
359
]
} |
description of a 70-year-old patient with a recurrent pleomorphic adenoma of the lower eyelid which originated form an adenoma of moll 's gland . | NA | {
"id": "C0026277",
"name": "pleomorphic adenoma",
"pos": [
54,
73
]
} | {
"id": "C0001430",
"name": "adenoma",
"pos": [
119,
126
]
} |
the long-term prognosis with symptomatic sinus node disease can be predicted in part by ( 1 ) etiology of the underlying heart disease , ( 2 ) pre-implant arrhythmia , and ( 3 ) ventricular function prior to implant . | NA | {
"id": "C0018799",
"name": "of the",
"pos": [
103,
109
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
155,
165
]
} |
substances having the chromatographic behaviour and the bioassay properties of prostaglandins ( pge and pgf ) were detected in the urine of 30 patients with kidney disease and 15 healthy subjects . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
79,
93
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
96,
99
]
} |
the effect could be related to enhanced transport of dgla to the active site of the cyclo-oxygenase enzyme complex , to a modification of the enzyme complex which changes the way it metabolizes dgla but not arachidonic acid or to two different enzymes . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
100,
114
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
244,
251
]
} |
however , there was a remarkable increase in the activity of beta-galactosidase when the cells from each of these cases were fused with those from the beta-galactosidase-deficient adult with cherry-red spots , cerebellar ataxia , myoclonus and neuraminidase deficiency in fibroblasts . | NA | {
"id": "C0007634",
"name": "the cells",
"pos": [
85,
94
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
272,
283
]
} |
1 medigoxin ( lanitop ) 300 microgram/day and digoxin ( lanoxin ) 500 microgram/day were compared in cross-over studies on healthy volunteers and on patients with uncontrolled atrial fibrillation . | NA | {
"id": "C0025132",
"name": "medigoxin",
"pos": [
2,
11
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
46,
53
]
} |
an attempt to compare the onset of the ventricular rate response to a single oral dose of medigoxin with that to digoxin gave inconclusive results . | NA | {
"id": "C0025132",
"name": "medigoxin",
"pos": [
90,
99
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
113,
120
]
} |
the histochemical activity of succinate dehydrogenase ( sdh ) , lactate dehydrogenase ( ldh ) , acetylcholinesterase ( ache ) and butyryl cholinesterase ( buche ) was studied in these unique muscle fibres . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
96,
116
]
} | {
"id": "C0008429",
"name": "butyryl cholinesterase",
"pos": [
130,
152
]
} |
since buche is a precursor in ache synthesis , the slow-tonic muscle fibres probably depend solely on the ache transported axonally . | NA | {
"id": "C0008429",
"name": "buche",
"pos": [
6,
11
]
} | {
"id": "C0001044",
"name": "ache",
"pos": [
106,
110
]
} |
this method is applied to the investigation of the influence of vitamin c ( sodium ascorbate ) on the glycolytic enzymes invertase , dextransucrase and dextranase . | NA | {
"id": "C0003968",
"name": "vitamin c",
"pos": [
64,
73
]
} | {
"id": "C0887557",
"name": "sodium",
"pos": [
76,
82
]
} |
data are presented to demonstrate reliability and simplicity of rapid estimation of gsh and gssg . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
84,
87
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
92,
96
]
} |
in the weanling hab-lesioned rats , body weight changes , body composition pituitary , weight , food and water intake , water/food-intake ratio , and plasma insulin were normal . | NA | {
"id": "C0005911",
"name": "body weight changes",
"pos": [
36,
55
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
87,
93
]
} |
experimental transmission using infective ocular discharges resulted in a conjunctivitis in young kids and a severe keratoconjunctivitis in an adult goat . | NA | {
"id": "C0009763",
"name": "conjunctivitis",
"pos": [
74,
88
]
} | {
"id": "C0022573",
"name": "keratoconjunctivitis",
"pos": [
116,
136
]
} |
evidence is presented that antibodies against staphylococcal peptidoglycan are important opsonins for phagocytosis of staphylococci . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
27,
37
]
} | {
"id": "C0029122",
"name": "opsonins",
"pos": [
89,
97
]
} |
since the imino acid content of collagen is greater than other proteins , it is suggested that the incorporation of a proline analog into cellular protein would have a maximal effect on collagen metabolism . | NA | {
"id": "C0020931",
"name": "imino acid",
"pos": [
10,
20
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
118,
125
]
} |
it was found that 30 % or more of the amino acid became incorporated into oocyte proteins and that this incorporation was due to direct transfer from the aminoacyl-trna and was inhibited by puromycin and cycloheximide . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
38,
48
]
} | {
"id": "C0035714",
"name": "aminoacyl-trna",
"pos": [
154,
168
]
} |
we propose that the actual concentration of free cations inside the living cell nuclei is regulated by a dynamic interaction between nuclear proteins and ions . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
49,
56
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
154,
158
]
} |
the first case of the disease in a male patient is reported as well as the development of a second tumor in the previously uninvolved eye of an adult patient and the marked enlargement of the tumor in another . | NA | {
"id": "C0085183",
"name": "second tumor",
"pos": [
92,
104
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
192,
197
]
} |
the maximum concentration of lymphotoxin generated in the medium has a limiting value that is independent of antigen concentration , leukocyte density , and duration of antigen exposure or leukocyte culture , suggesting feedback control of lymphokine production . | NA | {
"id": "C0024320",
"name": "lymphotoxin",
"pos": [
29,
40
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
240,
250
]
} |
this cytostasis is neither tumor-specific nor strain-restricted and the cells responsible for this inhibition of tumor cell multiplication have the characteristics of macrophages : they lack the thy 1-2 antigenic marker , appear in cy treated nude mice , stick on plastic vessels , and are retained by adherence columns ( nylon wool or sephadex g10 ) ; | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
264,
271
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
322,
327
]
} |
endogenous hyperlactatemia : this was induced either by pharmacological means : the subcutaneous injection of an antidiabetic biguanide , phenformin ( 20 mg/kg ) , or by physiological means : intense muscular work . | NA | {
"id": "C0005382",
"name": "biguanide",
"pos": [
126,
135
]
} | {
"id": "C0031404",
"name": "phenformin",
"pos": [
138,
148
]
} |
the intraluminal intestinal lipids of the oil and micellar phases were separated after microfiltration ( millipore filters ) in preference to the filtration by gel chromatography on polyacrylamide agarose , as an hydrolysis of intraluminal phospholipid occurred after the column elution . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
28,
34
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
42,
45
]
} |
after isolation of the micellar phases , no triglycerides were recovered , but fatty acids and partial glycerides from the hydrolysed tri-oleoylglycerol and dietary phosphatidylcholines and small quantities of lyso-phosphatidylcholines ( hydrolysed forms ) were present . | NA | {
"id": "C0041004",
"name": "triglycerides",
"pos": [
44,
57
]
} | {
"id": "C0017860",
"name": "glycerides",
"pos": [
103,
113
]
} |
immune complexes and some antibodies seem capable of promoting thrombosis , while a component of complement ( c1q ) may also have an antithrombotic role . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
0,
16
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
26,
36
]
} |
results from 14c-labeling experiments reflected a continuous and dynamic turnover of transmural triacylglycerol fatty acids , phospholipid fatty acids and tissue free fatty acids in control dogs with patent coronary arteries . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
112,
123
]
} | {
"id": "C0015688",
"name": "free",
"pos": [
162,
166
]
} |
a nonhemorrhagic infarct ( sen ) might occur at the stria terminalis in the perinatal period of the premature infant , following focal ischemia or hypoxia , and on occasion predispose to the production of subependymal hemorrhage in impaired cerebral vascular autoregulation . | NA | {
"id": "C0021308",
"name": "infarct",
"pos": [
17,
24
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
135,
143
]
} |
personal experience with 50 hospitalized patients treated surgically and with cefoxitin , a new cephamycin semisynthetic antibiotic resistant to beta-lactamases , is reported . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
78,
87
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
96,
106
]
} |
ch50 showed no variations during normal pregnancy , excepting for first trimester , whereas it increased in puerperium . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
40,
49
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
66,
81
]
} |
membrane markers of lymphomatous cells were studied in 33 patients with non hodgkin 's lymphoma and correlated with morphological diagnosis according to rappaport 's classification . | NA | {
"id": "C0024299",
"name": "lymphomatous",
"pos": [
20,
32
]
} | {
"id": "C0024305",
"name": "non",
"pos": [
72,
75
]
} |
this finding indicates that in the ventral tegmental area , which contains the cell bodies of dopaminergic neurons of the mesocortical and mesolimbic da systems , da may be released by a mechanism similar to that operating in the nerve endings . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
94,
106
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
163,
165
]
} |
it was found that ubiquinones are incorporated into mitochondria in different extents ranging from zero ( q1 ) to 10 fold ( q10 ) the concentration of endogenous q per mg of mitochondrial protein . | NA | {
"id": "C0041536",
"name": "ubiquinones",
"pos": [
18,
29
]
} | {
"id": "C0056077",
"name": "q10",
"pos": [
124,
127
]
} |
evidence is presented that ovine pancreatic ribonuclease , a protein strictly homologous to bovine rnaase a but with one positive charge less , has a definite 'destabilizing ' activity ( quite similar to that of the bovine enzyme ) on double-stranded dna . | NA | {
"id": "C0035541",
"name": "pancreatic ribonuclease",
"pos": [
33,
56
]
} | {
"id": "C0014241",
"name": "rnaase",
"pos": [
99,
105
]
} |
the results from addition and competition experiments are consistent with all effectors acting on lysosomal proteolysis but differing in whether they alter amounts of proteinases , conditions favourable for proteinase function , or degree of autophagocytosis . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
167,
178
]
} | {
"id": "C0030946",
"name": "proteinase",
"pos": [
207,
217
]
} |
significant bacteriuria was identified in 21 % of the women , though symptoms of urinary tract infection were found in about 25 % . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
12,
23
]
} | {
"id": "C0042029",
"name": "of urinary tract",
"pos": [
78,
94
]
} |
mutagenicity of cross-links and monoadducts of furocoumarins ( psoralen and angelicin ) induced by 360-nm radiation in excision-repair-defective and radiation-insensitive strains of saccharomyces cerevisiae . | NA | {
"id": "C0016859",
"name": "furocoumarins",
"pos": [
47,
60
]
} | {
"id": "C0016072",
"name": "psoralen",
"pos": [
63,
71
]
} |
the furocoumarin psoralen can form both monoadducts and cross-links with dna when combined with 360-nm radiation , whereas the analog angelicin can form monoadducts only . | NA | {
"id": "C0016859",
"name": "furocoumarin",
"pos": [
4,
16
]
} | {
"id": "C0016072",
"name": "psoralen",
"pos": [
17,
25
]
} |
the derivatives of cholic acid with basic aminoacids showed significant activity , especially marked when ( l ) -arginine was the condensed aminoacid . | NA | {
"id": "C0301714",
"name": "basic aminoacids",
"pos": [
36,
52
]
} | {
"id": "C0003765",
"name": "l",
"pos": [
108,
109
]
} |
the derivatives of cholic acid with basic aminoacids showed significant activity , especially marked when ( l ) -arginine was the condensed aminoacid . | NA | {
"id": "C0301714",
"name": "basic aminoacids",
"pos": [
36,
52
]
} | {
"id": "C0002520",
"name": "aminoacid",
"pos": [
140,
149
]
} |
four series of diethylaminoalkoxyderivatives of coumarin ( at the positions 4 and 7 ) and furocoumarin ( at the positions 5 and 8 ) have been prepared , in order to study their complexing capacity with dna , these compounds having a double possibility of interaction , that is intercalation of the aromatic moiety between two base pairs and formation of an electrostatic bond between their terminal amino group and a phosphoric group of dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
202,
205
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
439,
440
]
} |
the furocoumarin derivatives showed a markedly increased complexing capacity both in respect to the coumarin derivatives and to the parent furocoumarin ( psoralen , as well as its 5- and 8-methoxy derivatives ) and proved able to inhibit dna and rna synthesis in ehrlich ascites tumor cells , as well as the growth of staphylococcus aureus and of various strains of escherichia coli . | NA | {
"id": "C0016859",
"name": "furocoumarin",
"pos": [
4,
16
]
} | {
"id": "C0010207",
"name": "coumarin derivatives",
"pos": [
100,
120
]
} |
the furocoumarin derivatives showed a markedly increased complexing capacity both in respect to the coumarin derivatives and to the parent furocoumarin ( psoralen , as well as its 5- and 8-methoxy derivatives ) and proved able to inhibit dna and rna synthesis in ehrlich ascites tumor cells , as well as the growth of staphylococcus aureus and of various strains of escherichia coli . | NA | {
"id": "C0016859",
"name": "furocoumarin",
"pos": [
4,
16
]
} | {
"id": "C0016072",
"name": "psoralen",
"pos": [
154,
162
]
} |
the a.a. have examined by limulus endotoxin assay some lps preparations from r. typhi , r. slovaka , c. burnetti phase i and ii , as a demonstration of endotoxicity . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
34,
43
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
55,
58
]
} |
among the cephalosporin antibiotics , a relatively new derivative of cefamandole has been studied , the sodium salt of its formyl ester , cefamandole nafate . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
69,
80
]
} | {
"id": "C0054995",
"name": "cefamandole nafate",
"pos": [
138,
156
]
} |
the a.a. have examined by the limulus assay the possible endotoxin contamination in some biological products ( ribosomal vaccines , viral vaccines , interferon ) . | NA | {
"id": "C0005522",
"name": "biological products",
"pos": [
89,
108
]
} | {
"id": "C0042210",
"name": "vaccines",
"pos": [
138,
146
]
} |
the plasma angiotensin ii level required to return blood pressure to control was 45 +/- 15 pg/ml higher than the control plasma angiotensin ii level ( p < 0.01 ) , suggesting that some other factor ( s ) , perhaps bradykinin , are also responsible for the hypotensive response to converting enzyme inhibition . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
11,
25
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
128,
139
]
} |
the fibroblast cultures were infected with either irradiated or nonirradiated adenovirus and at 48 hours after infection , cells were examined for the presence of vag using immunofluorescent staining . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
4,
14
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
123,
128
]
} |
in particular , the s. aureus peptides obtained were important for establishing the amidation state of glutamic acid/glutamine residues . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
103,
116
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
117,
126
]
} |
the usefulness of this method lies in the fact that they can be applied immediately with minimal additional trauma , and the fracture can be immobilised whilst leaving the damaged area uncovered and thus available to carry out repairs and reconstruction of the soft tissues . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
108,
114
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
125,
133
]
} |
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