text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
maternal and fetal plasma concentrations of free fatty acids , triacylglycerols and phospholipids and the profile of their fatty acids were measured in three catheterized and unanaesthetized sheep . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
44,
60
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
123,
134
]
} |
only trace amounts of labelled fatty acids were found in fetal plasma and these were confined to the free fatty acids . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
31,
42
]
} | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
101,
117
]
} |
neutral amino acids were transported at higher rates than basic amino acids . l-arginine was poorly transported by the jejunum . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
58,
75
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
80,
88
]
} |
one of the field isolates resistant to dioxathion was also highly resistant to the carbamate , carbaryl , and to the organophosphorus ixodicides benoxophos and diazinon . | NA | {
"id": "C0006948",
"name": "carbamate",
"pos": [
83,
92
]
} | {
"id": "C0036860",
"name": "carbaryl",
"pos": [
95,
103
]
} |
in each family the spouse of the patient with overt haemochromatosis in the first generation had clinical and laboratory signs of moderate iron overload and a hla haplotype a3 , b14 and a3 , b7 respectively -- which is frequently associated with the haemochromatosis gene . | NA | {
"id": "C0018995",
"name": "haemochromatosis",
"pos": [
52,
68
]
} | {
"id": "C0282193",
"name": "iron overload",
"pos": [
139,
152
]
} |
on the basis of this preferential uptake of amino acids , radioactive iodine-labeled amino acids and peptides , gamma-131i-iodo-alpha-aminobutyric acid , n-2-131i-monoiodoacetyl-l- and d-leucines , l- and d-leucine 2-131i-iodoethyl esters , 125i or 131i-labeled dipeptides , and insulin 125i-a and 131i-b chains , were prepared and assayed for their distribution in mouse organs and ehrlich ascites tumor cells . | NA | {
"id": "C0301714",
"name": "basis",
"pos": [
7,
12
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
85,
96
]
} |
since a high incorporation into stomach was seen also after the administration of 125i-sodium iodide , it was suggested that iodine ions were liberated in vivo from the labeled compounds within a short time . | NA | {
"id": "C0037521",
"name": "sodium iodide",
"pos": [
87,
100
]
} | {
"id": "C0021966",
"name": "iodine",
"pos": [
125,
131
]
} |
in 14 patients the kinetics has been studied of two contrast media labelled with 131i , and namely of mgm diatrizoate and of diatrizoate of sodium and mgm . | NA | {
"id": "C0012004",
"name": "diatrizoate",
"pos": [
106,
117
]
} | {
"id": "C0012007",
"name": "diatrizoate",
"pos": [
125,
136
]
} |
lipid extracts were prepared from each sample gas chromatography tests were made on the esterified fats . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
0,
5
]
} | {
"id": "C0015677",
"name": "fats",
"pos": [
99,
103
]
} |
in pre-excitation syndrome , it has become possible to detect the abnormal pathway and to screen the patients susceptible to life-threatening arrhythmias . | NA | {
"id": "C0032915",
"name": "pre-excitation syndrome",
"pos": [
3,
26
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
142,
153
]
} |
separation and measurement of adenine-adenosine , adenosine monophosphate ( amp ) , adenosine diphosphate ( adp ) , adenosine triphosphate ( atp ) , lipid phosphates , rna and dna , further , separation and measurement of mg2+-dependent , total ( mg2+-dependent plus na+ -- k+-dependent , mg2+-na+-k-dependent ) and na+-k+-dependent atpases were carried out in the mucosa and muscles of the corpus , antrum and duodenum of 68 patients with antral ulcer . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
38,
47
]
} | {
"id": "C0001465",
"name": "adenosine monophosphate",
"pos": [
50,
73
]
} |
separation and measurement of adenine-adenosine , adenosine monophosphate ( amp ) , adenosine diphosphate ( adp ) , adenosine triphosphate ( atp ) , lipid phosphates , rna and dna , further , separation and measurement of mg2+-dependent , total ( mg2+-dependent plus na+ -- k+-dependent , mg2+-na+-k-dependent ) and na+-k+-dependent atpases were carried out in the mucosa and muscles of the corpus , antrum and duodenum of 68 patients with antral ulcer . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
38,
47
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
116,
138
]
} |
by electron microscopy , clear membrane-bound vacuoles were noted in lymphocytes ( but not in neurtrophils ) , fibroblasts , schwann cells , mural cells of the vasculature , and epidermal cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
111,
122
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
188,
193
]
} |
delayed paralysis of the deltoids due to selective anterior horn necrosis in a patient with traumatic tetraplegia . | NA | {
"id": "C0522224",
"name": "paralysis",
"pos": [
8,
17
]
} | {
"id": "C0034372",
"name": "tetraplegia",
"pos": [
102,
113
]
} |
in the case of aspergillus giganteus and its mutant a. giganteus mut . alba the major carotene is also beta-carotene ( 80 % ) with six other carotenoids , including possibly the acid pigment aspserxanthin . | NA | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
103,
116
]
} | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
141,
152
]
} |
the oxidation of one carbon compounds ( methane , methanol , formaldehyde , formate ) and primary alcohols ( ethanol , propanol , butanol ) supported the assimilation of [ 1-14c ] acetate by cell suspensions of type i obligate methylotroph , pseudomonas methanica , texas strain , and type ii obligate methylotroph , methylosinus trichosporium , strain pg . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
50,
58
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
109,
116
]
} |
[ antigenic and allergenic properties of various atypical mycobacteria and mycobacterium avium . ii . skin reactions to homologous and heterologous ppd preparations in artificially sensitized guinea pigs ] . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
2,
11
]
} | {
"id": "C0002092",
"name": "allergenic",
"pos": [
16,
26
]
} |
[ antigenic and allergenic properties of various atypical mycobacteria and mycobacterium avium . i. immunoelectrophoretic analysis of antigens in water extracts ] . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
2,
11
]
} | {
"id": "C0002092",
"name": "allergenic",
"pos": [
16,
26
]
} |
the complete inhibition of the enzyme activity with 10 ( -2 ) m eserine indicates that the che examined is ache . | NA | {
"id": "C0008429",
"name": "che",
"pos": [
91,
94
]
} | {
"id": "C0001044",
"name": "ache",
"pos": [
107,
111
]
} |
a follow-up of 78 twin pregnancies diagnosed in the first trimester indicated that early ovular resorption occurred in 63 % of spontaneous and 64 % of clomiphene-induced gestations , so that singletons were born . | NA | {
"id": "C0032979",
"name": "first trimester",
"pos": [
52,
67
]
} | {
"id": "C0032961",
"name": "gestations",
"pos": [
170,
180
]
} |
when allopurinol and azathioprine are administered simultaneously , high 6-mercaptopurine concentrations in plasma may be expected because of inhibition of xanthine oxidase activity by allopurinol . | NA | {
"id": "C0004482",
"name": "azathioprine",
"pos": [
21,
33
]
} | {
"id": "C0000618",
"name": "concentrations",
"pos": [
90,
104
]
} |
the percentage of cells containing sialidase-sensitive sialomucins was elevated , and percentage of cells containing neutral mucins was reduced . | NA | {
"id": "C0074477",
"name": "sialomucins",
"pos": [
55,
66
]
} | {
"id": "C0026682",
"name": "mucins",
"pos": [
125,
131
]
} |
by stimulation with morphine ( morphine sulfate ; 0.17 mg/kg iv bolus ) , waxing and waning of the pressured in the cbd without sphincteroplasty were observed with 20 cmh2o in maximum at about 13 minutes after injection . | NA | {
"id": "C0026549",
"name": "morphine",
"pos": [
20,
28
]
} | {
"id": "C0066814",
"name": "morphine sulfate",
"pos": [
31,
47
]
} |
[ prevention of recurrences and of epilepsy in febrile convulsions . protocol of the pediatric clinic of the florence and preliminary results ] . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
35,
43
]
} | {
"id": "C0009952",
"name": "febrile convulsions",
"pos": [
47,
66
]
} |
in the years 1974-1976 were also examined the consumption and cost for penicillin g , ampicillin and cephalosporins . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
71,
83
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
86,
96
]
} |
this defect did not appear to alter the absorption of primidone or phenobarbital , since increased dosages were not necessary to maintain these drugs within therapeutic ranges . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
54,
63
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
67,
80
]
} |
we present a new high pressure liquid chromatography ( hplc ) method for the simultaneous analysis of primidone , phenobarbital , phenytoin , and carbamazepine in serum . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
102,
111
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
114,
127
]
} |
also , a paired t-test indicates no significant difference for the hplc and emit values for primidone , phenobarbital , phenytoin , and carbamazepine . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
92,
101
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
104,
117
]
} |
the between-day precision of the analysis ( cv 5.0-7.0 % ) is acceptable , as is the recovery of hydrochlorothiazide ( 90-96 % ) and trichloromethiazide ( 96 % ) added to serum . | NA | {
"id": "C0020261",
"name": "hydrochlorothiazide",
"pos": [
97,
116
]
} | {
"id": "C0040899",
"name": "trichloromethiazide",
"pos": [
133,
152
]
} |
the pharmacokinetics of carbamazepine ( absorption , protein binding , distribution , metabolism , and elimination ) are reviewed , as well as the relationship between dose and plasma level and between plasma level and drug effects . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
86,
96
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
103,
114
]
} |
[ comparison of secretory iga in 3 cases of dysgammaglobulinemia : alpha chains disease , familial iga deficiency , mixed iga-igm dysgammaglobulinemia ] . | NA | {
"id": "C0162538",
"name": "iga deficiency",
"pos": [
99,
113
]
} | {
"id": "C0013374",
"name": "dysgammaglobulinemia",
"pos": [
130,
150
]
} |
[ thrombo-embolic disease and pregnancy . the prevention of pulmonary emboli by placing a clip on the inferior vena cava ( author 's transl ) ] . | NA | {
"id": "C0013922",
"name": "embolic",
"pos": [
10,
17
]
} | {
"id": "C0034065",
"name": "pulmonary emboli",
"pos": [
60,
76
]
} |
in this publication some brettanomyces strains that have common antigenic factor with salmonella 0:7 antigen and other brettanomyces strains that do n't have this common factor are shown together . | NA | {
"id": "C0003316",
"name": "antigenic factor",
"pos": [
64,
80
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
101,
108
]
} |
operationally defined as cfu-e ( erythrocyte ) , cfu-gm ( granulocyte/macrophage ) etc. , the ontogenetic relationships of these cells to each other and to the hsc have been the objects of exhaustive study . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
90,
93
]
} | {
"id": "C0018956",
"name": "hsc",
"pos": [
160,
163
]
} |
of 95 cases of perforating eye injury during the 4-year period 1973 to 1976 reviewed , 21 had a retained intraocular foreign body . | NA | {
"id": "C0015408",
"name": "of",
"pos": [
0,
2
]
} | {
"id": "C0015401",
"name": "retained intraocular foreign body",
"pos": [
96,
129
]
} |
[ the detection of serum and urine fibrin and fibrinogen degradation products by hemagglutination inhibition test ( author 's transl ) ] . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
35,
41
]
} | {
"id": "C0163275",
"name": "fibrinogen degradation products",
"pos": [
46,
77
]
} |
blood lactate levels were determined by lactate analyzer 640 kontron during the course of 7 cases of hyperglycemic hyperosmolar diabetic coma , with severe acidosis and more or less marked ketosis . | NA | {
"id": "C0001122",
"name": "acidosis",
"pos": [
156,
164
]
} | {
"id": "C0022638",
"name": "ketosis",
"pos": [
189,
196
]
} |
one of these cases presented with extreme acidosis and relatively mild hyperglycemia , with differential problems in regard to lactic acidosis . | NA | {
"id": "C0001122",
"name": "acidosis",
"pos": [
42,
50
]
} | {
"id": "C0001125",
"name": "lactic acidosis",
"pos": [
127,
142
]
} |
emphasis has been placed upon the distinctive roles of the liver and intestine in apolipoprotein synthesis and delivery , upon the complex interchange of lipids and apolipoproteins between lipoproteins which accompanies nascent lipoprotein maturation and metabolism within the vascular compartment , upon the primary role of these latter processes in the genesis of low density lipoprotein and upon remodelling of nascent lipoproteins to achieve a structure suitable for the function of the mature between the liver , intestine and peripheral tissues . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
154,
160
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
422,
434
]
} |
we report the influence on these analyses of albumin and globulin , two proteins commonly observed in urine in renal disease states . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
45,
52
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
72,
80
]
} |
we report the influence on these analyses of albumin and globulin , two proteins commonly observed in urine in renal disease states . | NA | {
"id": "C0017649",
"name": "globulin",
"pos": [
57,
65
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
72,
80
]
} |
the crithidia assay appeared to be specific for double-stranded dna antibodies , seemed to be more sensitive than the farr assay , and allowed us to determine the immunoglobulin classes of antibodies to native dna . | NA | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
163,
185
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
189,
199
]
} |
we carefully selected 30 men with primary gout , rendered asymptomatic by therapy , to examine the frequency and type of hyperlipidemia and hyperlipoproteinemia , with the objective of determining whether serum uric acid , alcohol intake , liver function , kidney function , and ( or ) drugs were participating in the secondary lipid disorder . | NA | {
"id": "C0020473",
"name": "hyperlipidemia",
"pos": [
121,
135
]
} | {
"id": "C0020476",
"name": "hyperlipoproteinemia",
"pos": [
140,
160
]
} |
and atomic absorption spectroscopy in which either extraction , carbon rod , graphite furnace , tantalum strip , or delves cup was used . | NA | {
"id": "C0007009",
"name": "carbon",
"pos": [
64,
70
]
} | {
"id": "C0302933",
"name": "graphite",
"pos": [
77,
85
]
} |
we report the determination of catecholamines ( dopamine , norepinephrine , and epinephrine ) and their 3-o-methylated metabolites ( 3-methoxytyramine , normetanephrine , and metanephrine ) in urine by gas chromatography/mass spectrometry , with use of stable isotopically labeled internal standards . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
59,
73
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
80,
91
]
} |
we report the determination of catecholamines ( dopamine , norepinephrine , and epinephrine ) and their 3-o-methylated metabolites ( 3-methoxytyramine , normetanephrine , and metanephrine ) in urine by gas chromatography/mass spectrometry , with use of stable isotopically labeled internal standards . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
59,
73
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
153,
168
]
} |
we report the determination of catecholamines ( dopamine , norepinephrine , and epinephrine ) and their 3-o-methylated metabolites ( 3-methoxytyramine , normetanephrine , and metanephrine ) in urine by gas chromatography/mass spectrometry , with use of stable isotopically labeled internal standards . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
62,
73
]
} | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
175,
187
]
} |
normal excretion values in terms of creatinine , expressed as a function of age , are given , together with results obtained for patients with neuroblastoma , ganglioneuroblastoma , pheochromocytoma , parkinsonism treated with l-dopa plus peripheral decarboxylase inhibitor , and a patient with cardiogenic shock treated with dopamine . | NA | {
"id": "C0027819",
"name": "neuroblastoma",
"pos": [
143,
156
]
} | {
"id": "C0206718",
"name": "ganglioneuroblastoma",
"pos": [
159,
179
]
} |
the spectrum of computed tomographic findings includes : calcified retinal tumor , intracranial subarachnoid spread of tumor , radiation-induced tumors ( papillary adenocarcinoma and undifferentiated sarcoma ) in the field of prior radiation , and second , primary central nervous system tumor , a pineoblastoma . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
75,
80
]
} | {
"id": "C0027666",
"name": "radiation-induced",
"pos": [
127,
144
]
} |
[ calcium , phosphorus and magnesium metabolism in the 1st days of life . ii . incidence of hypocalcemia , expressiveness of a specific symptomatology in hypocalcemic newborn infants , evaluation of the prevention with calcium gluconate and of the feeding starting time ] . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
2,
9
]
} | {
"id": "C0006699",
"name": "calcium",
"pos": [
219,
226
]
} |
comparing the result of this study with that of similar series from countries with a low prevalence of tuberculosis shows that there is a higher frequency of miliary pattern and a lower frequency of tuberculoma and primary tuberculosis in papua new guinea adults . | NA | {
"id": "C0041296",
"name": "tuberculosis",
"pos": [
103,
115
]
} | {
"id": "C0041295",
"name": "tuberculoma",
"pos": [
199,
210
]
} |
injection of t3 into thyroidectomized and euthyroid rats increased the specific activity ( at vmax ) of the ( na+ + k+ ) -dependent adenosine triphosphatase ( nak-atpase ) in jejunal crude membrane preparations . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
110,
112
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
163,
169
]
} |
the ion concentration changes were calculated by numerical solution of the unidimensional electrodiffusion equation under a variety of media compositions , axoplasmic diffusion coefficients , and internal anionic compositions . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
4,
7
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
205,
212
]
} |
the ion concentration changes and generation of diffusion potential can not be prevented by using side pools with cation content identical to that of the axoplasm . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
4,
7
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
114,
120
]
} |
the slow phases of oxonol association with , and release from , soybean lipid vesicles are not second order and have half times of between 0.2 and 5 min , depending on the physical and chemical composition of the membrane lipids . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
72,
77
]
} | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
213,
228
]
} |
calculation of the concentrations of free cations and cation-ligand complexes in solutions containing multiple divalent cations and ligands . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
42,
48
]
} | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
111,
127
]
} |
titrations measuring this paramagnetic effect at several enzyme concentrations in the presence of glucose-6-p yielded a characteristic enhancement factor for 1/t1 of water protons and the dissociation constant of cradp from the ternary enzyme . adpcr . glucose-6-p complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
57,
63
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
236,
242
]
} |
from the paramagnetic effects of enzyme-bound cradp on the relaxation rates of the 31p-nucleus and the carbon-bound protons of glucose-6-p in the enzyme . adpcr . glucose-6-p complex , using the correlation time of approximately 0.7 ns , determined from the magnetic field-dependence of 1/t1 of water protons over the range 24.3-360 mhz , a cr3+ to phosphorus distance of 6.6 +/- 0.7 a and cr3+ to alpha- and beta-anomeric proton distances of 8.9 and 9.7 a were calculated . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
33,
39
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
146,
152
]
} |
it appears that apical cellular nacl cotransport is necessary to obtain a reasonable cell chloride concentration . | NA | {
"id": "C0037494",
"name": "nacl",
"pos": [
32,
36
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
90,
98
]
} |
evidence for this interpretation comes from kinetics of incorporation of [ 3h ] thymidine into dna , which show that the time necessary to attain a new stable level of dna synthesis in irradiated cells is equivalent to that required for the replication fork to cover the interdimer distance in one strand . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
95,
98
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
301,
302
]
} |
these calculations are based on a refinement scheme that simultaneously fit several backbone modes of a-dna , b-dna , and a-rna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
104,
107
]
} | {
"id": "C0919262",
"name": "b-dna",
"pos": [
110,
115
]
} |
the kinetics of excision repair in confluent cultures of diploid human fibroblasts after ultraviolet irradiation at varying doses was measured by three different methods : ( a ) removal of thymine-containing dimers , ( b ) dna excision repair synthesis , and ( c ) biological recovery of cells from the potentially lethal effects of the irradiation . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
71,
82
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
288,
293
]
} |
the 24 h urinary epinephrine and norepinephrine excretion was significantly greater than normal the day before surgery ( 136 +/- 12 vs 39 +/- 4 micrograms/24 h , p less than 0.01 ) , and was still high two weeks after surgery ( 115.1 +/- 14 micrograms/24 h ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
17,
28
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
33,
47
]
} |
a flock of spring born lambs was continuously exposed to natural parasite infection from birth until selected for slaughter in groups of two or three , at monthly intervals throughout winter and spring for abomasal worm counts . | NA | {
"id": "C0030499",
"name": "parasite",
"pos": [
65,
73
]
} | {
"id": "C0018889",
"name": "worm",
"pos": [
215,
219
]
} |
their visualisation appeared to be enhanced when ruthenium red was incorporated n the glutaraldehyde-osmium fixative but only when sections were stained with heavy metal salts , indicating that the fimbriae and capsule were not predominantly polysaccharide in nature . | NA | {
"id": "C0029383",
"name": "osmium",
"pos": [
101,
107
]
} | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
158,
169
]
} |
in addition , a significant portion of the major hemoglobin component ( hb ao ) is also glycosylated by a glucose ketoamine linkage at other sites on the molecule , including the n-terminus of the alpha chain and the epsilon-amino group of several lysine residues on both the alpha and the beta chains . | NA | {
"id": "C0019016",
"name": "a",
"pos": [
3,
4
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
72,
74
]
} |
this minor hemoglobin , which arises as nonenzymatic postsynthetic addition of glucose to hemoglobin a , acts as an indicator molecule for the glucose environment over a 3-5-wk period prior to measurement . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
11,
21
]
} | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
90,
102
]
} |
at intervals after intraperitoneal injection of endotoxin ( 1 ld50 ) animals were killed , and blood glucose , liver glucose , and liver glycogen levels were killed , and blood glucose , liver glucose , and liver glycogen levels were measured . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
95,
108
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
193,
200
]
} |
in order to evaluate clearance and detoxification of endotoxin in non-responder mice , 14 c-labeled lipopolysaccharide was prepared from bacteria grown in broth containing d-glucose-14 c ( u ) . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
53,
62
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
100,
118
]
} |
with progression of sepsis severity , an unbalanced hyperdynamic recovery trajectory ( b state ) develops in which a decrease in oxygen consumption is associated with increases in the aromatic amino acids tyrosine , tryptophane , and phenylalanine ; | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
184,
204
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
205,
213
]
} |
with progression of sepsis severity , an unbalanced hyperdynamic recovery trajectory ( b state ) develops in which a decrease in oxygen consumption is associated with increases in the aromatic amino acids tyrosine , tryptophane , and phenylalanine ; | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
184,
204
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
234,
247
]
} |
thus , immunoreactive opsonic protein warrants clinical consideration as a noninvasive measure of reticuloendothelial systemic defense in patients after trauma and burn . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
153,
159
]
} | {
"id": "C0006434",
"name": "burn",
"pos": [
164,
168
]
} |
haemoglobin dibadan ( beta 87 threonine leads to lysine ) was originally found in ibadan , an area with a high incidence of sickle cell haemoglobin ( hbs ) . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
0,
11
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
137,
138
]
} |
with polyacrylamide model films incorporated with albumin , the reliability of off-peak measurements and the quantitative aspects of the modified protein staining procedures have been investigated . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
50,
57
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
146,
153
]
} |
a review of the barium enema studies in 73 patients with diverticular disease of the colon and with and without associated neoplasm leads to the conclusion that the correct radiologic recognition of an associated neoplasm in a colon with diverticulitis or diverticulosis can be made only about half the time . | NA | {
"id": "C0012819",
"name": "diverticular disease of",
"pos": [
57,
80
]
} | {
"id": "C0012814",
"name": "colon",
"pos": [
227,
232
]
} |
the evolution of this patient 's disease provides evidence that diffuse spasm and achalasia are different stages of the same disease and lie at opposite ends of a spectrum of related esophageal motility disorders . | NA | {
"id": "C0014848",
"name": "achalasia",
"pos": [
82,
91
]
} | {
"id": "C0014858",
"name": "esophageal motility disorders",
"pos": [
183,
212
]
} |
the beta-blocking activity of propranolol was studied on the positive inotropic effect of norepinephrine , epinephrine , isoproterenol , dopamine and ethylephrine , in the left atrium driven at different rates . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
90,
104
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
107,
118
]
} |
it was proved that the supernatant of 105 000 x g possessed a fatty acid synthetase able to synthesize de novo the saturated fatty acids of 10 to 18 carbons with a maximal yield in the myristic and palmitic acids . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
62,
72
]
} | {
"id": "C0030235",
"name": "palmitic acids",
"pos": [
198,
212
]
} |
in acute experiments , aldosterone ( aldo ) , 18-hydroxycorticosterone ( 18 oh b ) or corticosterone ( b ) were administered to adrenalectomized rats and parameters related to acid-base balance measured in urine samples collected for 3.5 hours after injection . | NA | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
46,
70
]
} | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
86,
100
]
} |
the pattern obtained for total hexose , fucose , hexosamines , sialic acid , fructose and sulphate demonstrated that in the domestic fowl 's oviduct the isthmus and the shell gland secrete the precursors for the protein carbohydrate substance of the mammillae and shell matrix and may contribute during the shell formation with the substrates necessary for the metabolic energy of the organ . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
31,
37
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
77,
85
]
} |
the dna alkaline elution technique has recently proven to be a simple , sensitive technique for the study of drug-induced dna damage and repair . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
4,
7
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
140,
141
]
} |
when sequential high dose drug-radiation cytoreductive regimens are employed , the interval between chemotherapy and total body irradiation ( tbi ) can markedly influence both toxicity in rapid cell renewal systems and the probability of successfully ablating normal and malignant hemopoietic stem cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
194,
198
]
} | {
"id": "C0018956",
"name": "hemopoietic stem cells",
"pos": [
281,
303
]
} |
blood glucose increases when glucose is administered orally or intravenously , but does not vary significantly with any other sugar . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
0,
13
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
29,
36
]
} |
the presence of dna sequences coding for 18 s and 28 s rna i.e . ribosomal rna ( r-rna ) , was demonstrated in the secondary constriction of acrocentric chromosomes using the rna-dna hybridization in situ method . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
65,
78
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
175,
178
]
} |
by means of dna-rna hybridization in situ it has been established that the secondary constrictions of acrocentric chromosomes contain sequences coding ribosomal rna synthesis . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
16,
19
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
151,
164
]
} |
sixteen patients with narcolepsy and cataplexy were treated with gamma-hydroxybutyrate ( ghb ) given at night and tailored to achieve as continuous a night 's sleep as possible . | NA | {
"id": "C0027404",
"name": "narcolepsy",
"pos": [
22,
32
]
} | {
"id": "C0007384",
"name": "cataplexy",
"pos": [
37,
46
]
} |
the resistance of these bacteria to available beta-lactam antibiotics , a variety of broad-spectrum agents , and available aminoglycosides other than amikacin led to an evaluation of cefoxitin , a beta-lactamase-resistant cephamycin . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
183,
192
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
222,
232
]
} |
cefoxitin , a new cephamycin antibiotic that is active against aerobic and anaerobic bacteria , was studied by 35 investigators in the united states . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
0,
9
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
18,
28
]
} |
for the staphylococci methicillin , oxacillin , and cloxacillin were introduced , and for gram-negative species , cefuroxime and cefoxitin . | NA | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
36,
45
]
} | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
52,
63
]
} |
the role of the 7-alpha-methoxy group in cefoxitin and the cephamycins in conferring stability in the presence of beta-lactamase is best rationalized by its steric bulk . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
41,
50
]
} | {
"id": "C0007736",
"name": "cephamycins",
"pos": [
59,
70
]
} |
the cephamycins are a family of beta-lactam antibiotics that are produced by actinomycetes and are structurally similar to the cephalosporins . | NA | {
"id": "C0007736",
"name": "cephamycins",
"pos": [
4,
15
]
} | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
127,
141
]
} |
the therapeutic effectiveness of cefoxitin in experimental infections in mice confirms the excellent characteristics of this semisynthetic cephamycin and indicates that it should be a very valuable agent for treatment of bacterial infections . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
33,
42
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
139,
149
]
} |
features of the distribution , metabolism , elimination , and pharmacokinetics of the cephalosporins and cefoxitin must be considered when concentrations of these drugs in biological fluids are interpreted . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
31,
41
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
44,
55
]
} |
although bovine plasma also contains a 4.2 s globulin only a 5.7 s protein was found in bovine milk . | NA | {
"id": "C0017649",
"name": "globulin",
"pos": [
45,
53
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
67,
74
]
} |
2,4-dinitrophenol ( 2,4-dnp ) in substrate level concentrations ( 200 microm-1 mm ) temporarily inhibits h2 production by tritrichomonas foetus and trichomonas vaginalis as well as the accumulation of metronidazole , dependent on its reduction by the two trichomonad species and by entamoeba invadens . | NA | {
"id": "C0012466",
"name": "dinitrophenol",
"pos": [
4,
17
]
} | {
"id": "C0045511",
"name": "dnp",
"pos": [
24,
27
]
} |
hemoglobin from winter-hibernating or summer-induced hibernating ground squirrels does not revert to a fetal type of hemoglobin . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
0,
10
]
} | {
"id": "C0015936",
"name": "fetal",
"pos": [
103,
108
]
} |
plasma concentrations of cholesterol , cholesteryl esters , phospholipids and triglycerides were determined for ten species of brazilian lizards , iguana iguana , tropidurus torquatos and t. semitaeniatus ( iguanidae ) , tupinambis teguixin , ameiva ameiva and cnemidophorus ocellifer ( teiidae ) , mabuya maculata ( scincidae ) , hemidactylus mabouia ( gekkonidae ) , amphisbaenia vermicularis and leposternon polystegum ( amphisbaenidae ) . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
25,
36
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
39,
57
]
} |
both peroxidases catalyze the oxidation of a number of substrates , and one peroxidase possesses a specificity similar to the terrestrial fungal enzyme chloroperoxidase . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
5,
16
]
} | {
"id": "C0027021",
"name": "peroxidase",
"pos": [
158,
168
]
} |
both peroxidases catalyze the oxidation of a number of substrates , and one peroxidase possesses a specificity similar to the terrestrial fungal enzyme chloroperoxidase . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
5,
16
]
} | {
"id": "C0008202",
"name": "chloroperoxidase",
"pos": [
152,
168
]
} |
tag from acetate was predominantly in the fatty acid portion of saponified lipids and also occurred in the unesterified fatty acids . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
42,
52
]
} | {
"id": "C0015688",
"name": "unesterified fatty acids",
"pos": [
107,
131
]
} |
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