text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
leopard frog ( rana pipiens ) erythrocytes are agglutinated by the plant lectins concanavalin a and phytohemagglutinin . | NA | {
"id": "C0304052",
"name": "plant",
"pos": [
67,
72
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
81,
95
]
} |
homogenization of rat adipocytes was found to inhibit the transfer of newly synthesized phospholipids and glycerides from the membranes to the storage lipids . | NA | {
"id": "C0017860",
"name": "glycerides",
"pos": [
106,
116
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
151,
157
]
} |
plasma and serum samples obtained from various animals never previously exposed to snakes or snake venom were diffused against different concentrations of puff-adder , bitis arietans , venom using the double immunodiffusion technique . | NA | {
"id": "C0037380",
"name": "snake venom",
"pos": [
93,
104
]
} | {
"id": "C0042479",
"name": "venom",
"pos": [
185,
190
]
} |
the isoenzyme patterns of four soluble enzymes in seven stocks of t. cruzi were determined by electrophoresis . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
4,
13
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
39,
46
]
} |
the activity of hepatic gamma-amylase is approximately one-half that of glycogen phosphorylase in carp whereas in goldfish , the activity of gamma-amylase is less than one-sixth that of phosphorylase . | NA | {
"id": "C0917785",
"name": "glycogen phosphorylase",
"pos": [
72,
94
]
} | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
186,
199
]
} |
three patients , in whom tumour overkill by cytotoxic treatment , including high dose methotrexate with folinic acid rescue , resulted in the 'phosphate shower syndrome ' ( hyper-uricaemia , hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany , with metabolic acidosis and acute renal impairment ) are described . | NA | {
"id": "C0020598",
"name": "hypocalcaemia",
"pos": [
233,
246
]
} | {
"id": "C0039621",
"name": "tetany",
"pos": [
251,
257
]
} |
central injection of a long lasting enkephalin analog ( d-ala2-leu-enkephalin-amide ) produced a syndrome of stereotyped motor activity . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
36,
46
]
} | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
63,
77
]
} |
the effects of apomorphine and sodium di-n-propylacetate ( dpa , sodium valproate ) on pain-induced aggressive behavior were investigated in three inbred strains of mice : balb/c , c57b1/6 and dba/2 , which exhibited spontaneously low levels of aggression . | NA | {
"id": "C0042291",
"name": "dpa",
"pos": [
59,
62
]
} | {
"id": "C0037567",
"name": "sodium",
"pos": [
65,
71
]
} |
comparisons between automated suprathreshold static perimetry and manual kinetic perimetry were performed for 226 eyes with glaucoma or ocular hypertension , and 147 eyes with other optic nerve disease . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
124,
132
]
} | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
136,
155
]
} |
to test whether cdc8 codes for a dna polymerase , we have purified both dna polymerase i and dna polymerase ii from cdc8 and cdc+ cells . | NA | {
"id": "C0012892",
"name": "dna polymerase",
"pos": [
33,
47
]
} | {
"id": "C0012889",
"name": "dna polymerase ii",
"pos": [
93,
110
]
} |
in contrast to this child , a further 10 infants and young children with bacterial meningitis , whose csf was examined between 4 weeks and 6 3/4 months subsequent to onset of the disease , showed no such abnormality . | NA | {
"id": "C0008059",
"name": "child",
"pos": [
20,
25
]
} | {
"id": "C0728836",
"name": "young children",
"pos": [
53,
67
]
} |
a sensitive assay for direct measurement of esterase activity using p-tosyl-l-arginine ( 3h ) methyl ester ( 3h-tame ) as substrate is described . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
78,
86
]
} | {
"id": "C0040494",
"name": "tame",
"pos": [
112,
116
]
} |
the nylon wool adherent fraction was removed by mechanical agitation and further separated on the basis of adherence to a coated-plastic surface in the presence of autologous serum . | NA | {
"id": "C0028736",
"name": "nylon",
"pos": [
4,
9
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
129,
136
]
} |
coccidians use intensively the purine base 14c-adenine , assimilate negligibly the pyrimidine base 14c-uracil and nucleoside 14c-uridine and do not use at all 14c-thymidine and 14c-thymine . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
31,
37
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
47,
54
]
} |
coccidians use intensively the purine base 14c-adenine , assimilate negligibly the pyrimidine base 14c-uracil and nucleoside 14c-uridine and do not use at all 14c-thymidine and 14c-thymine . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
103,
109
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
181,
188
]
} |
the paper describes a modification of the method of stoloff et al . allowing a simultaneous measurement of eight mycotoxins ( aflatoxins b1 , b2 , g1 , g2 , ochratoxin a , sterigmatocystin , citrinin , patulin ) in the grain extract on standard plates silufol . | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
113,
123
]
} | {
"id": "C0038274",
"name": "sterigmatocystin",
"pos": [
172,
188
]
} |
the paper describes a modification of the method of stoloff et al . allowing a simultaneous measurement of eight mycotoxins ( aflatoxins b1 , b2 , g1 , g2 , ochratoxin a , sterigmatocystin , citrinin , patulin ) in the grain extract on standard plates silufol . | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
113,
123
]
} | {
"id": "C0030710",
"name": "patulin",
"pos": [
202,
209
]
} |
an addition of alpha-tocopherol ( i ) and its synthetic derivatives ( alpha-tocopheryl quinone ( ii ) , its short-chained analog ( iii ) , alpha-tocopherol lactone ( iv ) , and short-chained alpha-tocopheryl acetate ( v ) ) to the homogenized liver of vitamin e deficient rats resulted in a significant increase of ubiquinone after 2 hour incubation . | NA | {
"id": "C0969677",
"name": "alpha-tocopherol",
"pos": [
15,
31
]
} | {
"id": "C1999896",
"name": "alpha-tocopheryl acetate",
"pos": [
191,
215
]
} |
chronic administration of insulin up to 14 days of life does not affect the growth rate and the content of protein and glycogen in muscles , but increases glycogen content of the liver . | NA | {
"id": "C0017911",
"name": "glycogen",
"pos": [
119,
127
]
} | {
"id": "C0023902",
"name": "glycogen",
"pos": [
155,
163
]
} |
effects of a systematic application of human chorionic gonadotropin , gonadotropin-releasing hormone analog and bovine anterior pituitary gonadotropin in cows with cystic ovarian disease . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotropin",
"pos": [
39,
67
]
} | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
138,
150
]
} |
if the cows did not respond to both hcg and gn-rh analog , they may not respond to apg either . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
36,
39
]
} | {
"id": "C0018061",
"name": "apg",
"pos": [
83,
86
]
} |
beef cows fed 0.37 kg crude protein/day during the last four months of pregnancy had significantly shortened gestation ( 274 days vs. 282 days ) and decreased weight gain ( 25 kg vs. 66 kg ) compared to control cows fed 0.96 kg crude protein/day . | NA | {
"id": "C0032974",
"name": "protein",
"pos": [
28,
35
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
234,
241
]
} |
independent variables were birth weight ( bw ) , pelvic area ( pa ) , bw . ( 33 ) , pa. ( 5 ) , cow weight ( cw ) , cow condition score ( cs ) and sex of calf ( s ) . | NA | {
"id": "C0005612",
"name": "bw",
"pos": [
42,
44
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
100,
106
]
} |
when bw , pa , cw , cs and s were included in the model , the r ( 2 ) values for cd-i were .40 and .42 for the linear and quadratic analyses ( cubic effects were not tested ) . | NA | {
"id": "C0005612",
"name": "bw",
"pos": [
5,
7
]
} | {
"id": "C0005910",
"name": "cw",
"pos": [
15,
17
]
} |
in all analyses , the order of importance of the factors studied was bw and pa , with a much lower contribution from cw and s . | NA | {
"id": "C0005612",
"name": "bw",
"pos": [
69,
71
]
} | {
"id": "C0005910",
"name": "cw",
"pos": [
117,
119
]
} |
restriction enzyme analysis of viral dna preparations derived from several single plaque isolates of acnpv as well as of dna from different virus stocks revealed a certain heterogeneity of the acnpv dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
37,
40
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
201,
202
]
} |
apparent molar heat capacities phic ( p ( 1,3 ) ) of uracil , thymine and a series of their alkylated derivatives : m ( 1 ) ura , m ( 1,3 ) ( 2 ) ura , m ( 1,3 ) ( 2 ) thy , mi ( 1,3,6 ) ( 3 ) ura , m ( 1,3 ) ( 2 ) , e ( 5 ) ura and e ( 1,3 ) ( 2 ) thy in dilute aqueous solutions were measured in the temperature range of 293.15-388.15 k , using a differential adiabatic scanning microcalorimeter . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
53,
59
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
62,
69
]
} |
dull pink globules were found within the epidermis in 65 % of junctional , 75 % of compound , and 25 % of intradermal types of spitz 's nevi ( the nevi of large spindle and/or epithelioid cells ) . | NA | {
"id": "C0206737",
"name": "intradermal",
"pos": [
106,
117
]
} | {
"id": "C0027960",
"name": "nevi",
"pos": [
147,
151
]
} |
it has been demonstrated that both stnv-rna and sat-rna are significantly more resistant to inactivation in vitro than the rnas of their helper viruses . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
40,
43
]
} | {
"id": "C0074081",
"name": "sat-rna",
"pos": [
48,
55
]
} |
the thermal denaturation kinetics of stnv-rna and sat-rna , unlike those of tnv-rna and cmv-rna , are more like those of transfer rna ( trna ) indicating that a high proportion of their nucleotides are involved in base pairing . | NA | {
"id": "C0074081",
"name": "sat-rna",
"pos": [
50,
57
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
137,
140
]
} |
the thermal denaturation kinetics of stnv-rna and sat-rna , unlike those of tnv-rna and cmv-rna , are more like those of transfer rna ( trna ) indicating that a high proportion of their nucleotides are involved in base pairing . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
42,
45
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
121,
133
]
} |
stnv-rna , sat-rna , and trna also show similar degrees of resistance to degradation by the single strand-specific s ( 1 ) nuclease . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
5,
8
]
} | {
"id": "C0074081",
"name": "sat-rna",
"pos": [
11,
18
]
} |
it is suggested that both stnv-rna and sat-rna may owe their in vitro stability to features of their molecular structure which may also account for their ability to survive in vivo for prolonged periods without replication . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
31,
34
]
} | {
"id": "C0074081",
"name": "sat-rna",
"pos": [
39,
46
]
} |
the latter messenger has mainly been detected in two types of minor components , those which have an rna content exceeding that of the major tymv virions and particles which contain the coat protein messenger as their sole rna constituent . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
101,
104
]
} | {
"id": "C0035696",
"name": "messenger",
"pos": [
199,
208
]
} |
when the b1 nucleoprotein is subjected to ph 11.5-11.6 in 1 m kcl ( conditions under which artificial empty protein shells are formed ) , the apparent radius ( r ) of the virus increases from about 14.6 to 15.2 nm within 30 sec . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
12,
25
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
108,
115
]
} |
since the viral rna showed a marked tendency to aggregate , it is possible that these polypeptides were translated from trace amounts of small emv rnas present as contaminants of the 1.9 x 10 ( 5 ) -dalton genomic rna . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
10,
19
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
214,
217
]
} |
pressure gradients in a diamond anvil cell have been measured with a 4:1 methanol : ethanol mixture as a pressure medium up to 350 kilobars . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
73,
81
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
84,
91
]
} |
for liquids containing water , polyimides films are used since this polymer is far less susceptible to the electron beam damage observed for the commonly used polymer films such as formvar and collodion in contact with ice . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
23,
28
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
219,
222
]
} |
a practical , easily constructed design for a laboratory hydrogen/deuterium halide chemical tea laser is presented . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
57,
65
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
66,
75
]
} |
some preparative results on anionic sigma-complex formation reactions are presented up to 1.5 kbar between 2,4,6-trinitrobenzene ( i ) and hydroxide ion and between compound ( i ) and sulfite ion in water . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
28,
35
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
196,
197
]
} |
some preparative results on anionic sigma-complex formation reactions are presented up to 1.5 kbar between 2,4,6-trinitrobenzene ( i ) and hydroxide ion and between compound ( i ) and sulfite ion in water . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
28,
35
]
} | {
"id": "C0038750",
"name": "sulfite",
"pos": [
184,
191
]
} |
some preparative results on anionic sigma-complex formation reactions are presented up to 1.5 kbar between 2,4,6-trinitrobenzene ( i ) and hydroxide ion and between compound ( i ) and sulfite ion in water . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
28,
35
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
192,
195
]
} |
the results of cross-absorptions of cell line antisera with cells of the different lines suggested that no identical common tumour-specific cell surface antigen was detectable serologically in addition to histocompatibility antigens or other normal cell surface antigens . | NA | {
"id": "C0019628",
"name": "histocompatibility antigens",
"pos": [
205,
232
]
} | {
"id": "C0003339",
"name": "cell surface antigens",
"pos": [
249,
270
]
} |
the results of vaccination experiments with chicken embryo fibroblasts and with cells from various lymphoid tissues indicated that resistance against jmv lymphoblastic leukaemia could be induced by a number of different antigens which were not specific to marek 's disease . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
59,
70
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
80,
85
]
} |
automated determination of hydrogen cyanide acrolein and total aldehydes in the gas phase of tobacco smoke . | NA | {
"id": "C0001204",
"name": "acrolein",
"pos": [
44,
52
]
} | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
63,
72
]
} |
on dissociation in alkaline medium , the orange hl gives the blood-red anion l ( - ) and extracts alkali metal ions into chloroform as coloured complexes of composition ml.hl or ml . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
71,
76
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
111,
115
]
} |
certain sulphur compounds such as thiosulphuric acid , polythionic acids , thiocyanic acid , thioureas , thioamides and 2-mercapto-acids are readily electrolytically hydrogenated in 1n sulphuric acid to form hydrogen sulphide which is absorbed in potassium hydroxide solution and titrated with o-hydroxymercuribenzoic acid in the presence of dithizone as indicator . | NA | {
"id": "C0038776",
"name": "sulphur compounds",
"pos": [
8,
25
]
} | {
"id": "C0039958",
"name": "thioureas",
"pos": [
93,
102
]
} |
the anion-exchange behaviour of 30 metal ions on a weakly basic ion-exchanger ( deae-cellulose ) has been investigated in aqueous oxalic acid media over the concentration range 0.0010-0.50 m . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
4,
9
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
167,
170
]
} |
accurate determination of sulphur in steels and certain heat-resisting alloys by isotope dilution mass spectrometry . | NA | {
"id": "C0038239",
"name": "steels",
"pos": [
37,
43
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
71,
77
]
} |
a mass spectrometric isotope dilution method for the determination of sulphur in steels and certain alloys has been investigated . | NA | {
"id": "C0038239",
"name": "steels",
"pos": [
81,
87
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
100,
106
]
} |
to determine thiosulphate in the presence of dithionite and sulphite , iodine dissolved in potassium bromide solution is used to oxidize thiosulphate to tetrathionate , and dithionite and sulphite to sulphate . | NA | {
"id": "C0039950",
"name": "thiosulphate",
"pos": [
13,
25
]
} | {
"id": "C0038720",
"name": "sulphate",
"pos": [
200,
208
]
} |
to determine thiosulphate in the presence of dithionite and sulphite , iodine dissolved in potassium bromide solution is used to oxidize thiosulphate to tetrathionate , and dithionite and sulphite to sulphate . | NA | {
"id": "C0012787",
"name": "dithionite",
"pos": [
45,
55
]
} | {
"id": "C0038750",
"name": "sulphite",
"pos": [
188,
196
]
} |
a highly sensitive and simple method for determination of vanadium in plants and biological samples by solvent extraction and flameless atomic-absorption spectrometry with a carbon tube coated with pyrolytic graphite is described . | NA | {
"id": "C0007009",
"name": "carbon",
"pos": [
174,
180
]
} | {
"id": "C0302933",
"name": "graphite",
"pos": [
208,
216
]
} |
from the shape of the profiles it is concluded that an inflow of water at intermediate depths provides a source of heat to drive a regime in which ice is melted from the interface at a depth of 360 meters . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
65,
70
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
147,
150
]
} |
thermohaline observations in the water column beneath the ross ice shelf and along its terminal face show significant vertical stratification , active horizontal circulation , and net melting at the ice shelf base . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
33,
38
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
199,
202
]
} |
measurements of these isotopes in seawater under the ross ice shelf in mcmurdo sound show that this water has a different history . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
58,
61
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
100,
105
]
} |
there was no association between retinoids and risk of vulvar lichen sclerosus , but intake of carotenoids was inversely and strongly associated with vulvar lichen sclerosus . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
33,
42
]
} | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
95,
106
]
} |
in 22 eyes without clinical evidence of silicone-associated complications at the time of silicone oil removal , postoperative visual acuity remained unchanged or improved in 20 ( 91 % ) . | NA | {
"id": "C0037114",
"name": "silicone",
"pos": [
40,
48
]
} | {
"id": "C0037111",
"name": "silicone oil",
"pos": [
89,
101
]
} |
in five eyes visual acuity was 20/400 or poorer because of cystoid macular edema , as documented by fluorescein angiography , age-related macular degeneration , or optic atrophy . | NA | {
"id": "C0024440",
"name": "cystoid macular",
"pos": [
59,
74
]
} | {
"id": "C0242383",
"name": "age-related macular",
"pos": [
126,
145
]
} |
the muscle isozyme of adenylosuccinate synthetase ( adss ) , an enzyme of the purine nucleotide cycle , has previously been shown to bind to purified f-actin in buffers of low ionic strength and ph ( ogawa et al . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
11,
18
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
64,
70
]
} |
five dogs were studied during paired experiments in which pancreatic hormones were clamped at basal levels during a control period ( using somatostatin and intraportal hormone replacement ) , then altered during exercise to stimulate the normal exercise-induced fall in insulin , while glucagon was 1 ) increased to mimic its normal exercise-induced rise ( sg ) and 2 ) maintained at a basal level ( bg ) . | NA | {
"id": "C0030292",
"name": "pancreatic hormones",
"pos": [
58,
77
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
139,
151
]
} |
the synthetic enkephalin analogue , [ d-ala2 ] met-enkephalinamide ( dala ) was used to investigate opioid peptide modulation of lacrimal protein secretion . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
14,
24
]
} | {
"id": "C0205753",
"name": "opioid peptide",
"pos": [
100,
114
]
} |
these results demonstrate that , in contrast to other gastrin-cck receptor antagonists described , l365,260 is a selective gastrin receptor antagonist having an 80-fold higher affinity for gastrin than pancreatic cck receptor , whereas l364,718 has a 125-fold higher affinity for pancreatic cck receptors . | NA | {
"id": "C0248266",
"name": "gastrin",
"pos": [
54,
61
]
} | {
"id": "C0034791",
"name": "cck receptor",
"pos": [
291,
303
]
} |
these results demonstrate that , in contrast to other gastrin-cck receptor antagonists described , l365,260 is a selective gastrin receptor antagonist having an 80-fold higher affinity for gastrin than pancreatic cck receptor , whereas l364,718 has a 125-fold higher affinity for pancreatic cck receptors . | NA | {
"id": "C0034791",
"name": "cck receptor",
"pos": [
62,
74
]
} | {
"id": "C0250571",
"name": "a",
"pos": [
286,
287
]
} |
in the present study we examined the effect of gastrin , the cooh-terminal octapeptide of cck ( cck-8 ) , and the tetrapeptide of cck ( cg-4 ) on contraction of dispersed gastric smooth muscle cells from guinea pig and tested the ability of various cck receptor antagonists to affect agonist-induced muscle cell contraction . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
47,
54
]
} | {
"id": "C0039659",
"name": "tetrapeptide",
"pos": [
114,
126
]
} |
thus fish oil ingestion protected the gastric mucosa even though fish oils reduced mucosal prostaglandin synthesis . | NA | {
"id": "C0028908",
"name": "oil",
"pos": [
10,
13
]
} | {
"id": "C0016157",
"name": "fish oils",
"pos": [
65,
74
]
} |
these phosphoproteins could be common elements of ca2+-dependent stimulus-secretion coupling as similar proteins were phosphorylated by carbachol and cholecystokinin ( cck ) in chief cells . | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
6,
21
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
104,
112
]
} |
the brain levels of dopamine and norepinephrine ( no epinephrine was found in brain ) remained relatively constant even after nearly 1 wk of anoxia , indicating very well-functioning transmitter reuptake mechanisms and/or the absence of o2-independent degradation . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
33,
47
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
53,
64
]
} |
the data on total synthesis of the neurohypophysial hormones provide a reference for studies in which physiological replacement is required and also provide the technique and base-line data to determine how translation of vasopressin and oxytocin is regulated when neurohypophysial function is altered . | NA | {
"id": "C0032017",
"name": "neurohypophysial hormones",
"pos": [
35,
60
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
238,
246
]
} |
the induction of overfed obesity in one parabiotic partner was employed to test the hypothesis that a putative lipostatic factor produced in the obese parabiotic elicited the hypophagic-lipid-mobilizing effect observed in the lean parabiotic via alterations in hypothalamic fatty acid and glucose metabolism . | NA | {
"id": "C1257763",
"name": "overfed",
"pos": [
17,
24
]
} | {
"id": "C0028754",
"name": "obese",
"pos": [
145,
150
]
} |
the hypercalcemia was associated with increased uptake of calcium from the water ( resulting from increased influx and decreased efflux ) and with enhanced high-affinity ca2+-adenosinetriphosphatase ( atpase ) activity in the gills , the putative biochemical correlate of the branchial ca2+ pump . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
170,
173
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
201,
207
]
} |
multiple lymphomatous polyposis of the gastrointestinal tract was initially described as mucosal lymphomatous involvement by any of a variety of hodgkin 's or non-hodgkin 's lymphomas that produced a polypoid appearance over long segments of the gastrointestinal tract . | NA | {
"id": "C0024299",
"name": "lymphomatous",
"pos": [
9,
21
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
159,
183
]
} |
plasma catecholamines were in the high ranges , similar in both groups at 0 and 3 hr , but after 5 hr p greater than l for norepinephrine ( but not epinephrine or dopamine ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
123,
137
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
148,
159
]
} |
male ( n = 50 ) and female ( n = 46 ) rats were administered 2.5 g/kg ethanol ( i.p . ) and the blood-ethanol concentration ( bec ) at the time of regain of aerial righting reflex ( rarr ) was measured . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
70,
77
]
} | {
"id": "C0684262",
"name": "blood-ethanol",
"pos": [
96,
109
]
} |
thirty-two hours following the cessation of chronic ethanol exposure , the rats were again given a 2.5 g/kg dose of ethanol and the bec at rarr was again measured . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
52,
59
]
} | {
"id": "C0684262",
"name": "bec",
"pos": [
132,
135
]
} |
six months after severe thiamine deficiency , when their body and liver weights had normalized , male sprague-dawley rats were exposed to constant ethanol vapor concentrations for 6 days in an inhalation chamber and blood ethanol concentrations ( becs ) were determined . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
147,
154
]
} | {
"id": "C0684262",
"name": "blood ethanol",
"pos": [
216,
229
]
} |
eye vapor response and blood alcohol concentration were also found to be highly correlated ( r = 0.96 ) after alcohol administration to mice and sampling for 2.5 hr after ethanol administration . | NA | {
"id": "C0684262",
"name": "blood alcohol concentration",
"pos": [
23,
50
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
171,
178
]
} |
radioiodinated epidermal growth factor ( egf , mr 6045 , pi 4.4 ) , transforming growth factor type alpha ( tgf alpha , mr 5623 , pi 6.8 ) , insulin-like growth factor ( igf-i , mr 7649 , pi 8.3 ) , and basic fibroblast growth factor ( bfgf , mr 15,000-17,000 , pi 9.6 ) all transferred with high efficiency ( 74.1 +/- 12.6 % ) to a positively charged nylon membrane . | NA | {
"id": "C0037657",
"name": "insulin-like growth factor",
"pos": [
141,
167
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
170,
175
]
} |
vitamin k ( menaquinone ) biosynthesis in bacteria : high-performance liquid chromatographic assay of the overall synthesis of o-succinylbenzoic acid and of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase . | NA | {
"id": "C0042878",
"name": "vitamin k",
"pos": [
0,
9
]
} | {
"id": "C0086605",
"name": "menaquinone",
"pos": [
12,
23
]
} |
the remaining uncomplexed pg monomers were determined by incubation with specific monoclonal antibodies to habr followed by addition of polyclonal antibodies against pg monomers and enzyme-conjugated antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
82,
103
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
200,
210
]
} |
detection of unusual nucleic acids with monoclonal antibodies specific for triplexes , poly ( adp-ribose ) , dna-rna hybrids , and z-dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
109,
112
]
} | {
"id": "C0043442",
"name": "z-dna",
"pos": [
131,
136
]
} |
these include jel 318 which is specific for triplexes , adp-1 specific for poly ( adp-ribose ) , jel 99 specific for rna-dna duplexes , and jel 150 specific for z-dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
121,
124
]
} | {
"id": "C0043442",
"name": "z-dna",
"pos": [
161,
166
]
} |
it is concluded that thiobarbiturates are more potent vasoconstrictors than oxybarbiturates and that the barbiturates produce greater contraction in cerebral arteries than in extracerebral arteries . | NA | {
"id": "C0039880",
"name": "thiobarbiturates",
"pos": [
21,
37
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
105,
117
]
} |
the albumin/total protein ratio ( the albumin percentage ) in tb lavages was also significantly increased ( 1.4 x , 1.7 x , and 2.5 x in three separate experiments , respectively ) , indicating the vascular origin of the increased luminal proteins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
4,
11
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
239,
247
]
} |
sp15 was extracted from lyophilized pig pulmonary surfactant with 5 % triton x-100 and purified by deae-cellulose , cm-cellulose , and affinity chromatography with a specific antibody . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
99,
113
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
119,
128
]
} |
collagen production was measured as bacterial collagenase-susceptible radioactivity , and collagen mrna levels were determined by a solution hybridization assay using labeled procollagen alpha 1 [ i ] cdna clone hf677 as probe . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
0,
8
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
175,
186
]
} |
these results suggest that guinea pigs with hydrops as produced by our procedure can serve as a useful model of meniere 's disease , that autoimmune response may play an important role in the etiopathogenesis of meniere 's disease , and that spiral ganglion cell degeneration together with endolymphatic hydrops seems to contribute to abnormal changes in ap . | NA | {
"id": "C0025281",
"name": "meniere 's disease",
"pos": [
112,
130
]
} | {
"id": "C0206586",
"name": "endolymphatic hydrops",
"pos": [
290,
311
]
} |
renin , related to other aspartyl proteases , plays an important role in the cascade which regulates blood pressure and salt metabolism . | NA | {
"id": "C0035094",
"name": "renin",
"pos": [
0,
5
]
} | {
"id": "C0078989",
"name": "aspartyl proteases",
"pos": [
25,
43
]
} |
of these twelve patients , five had a refractory anemia ( ra ) and seven a refractory anemia with excess of blasts ( raeb ) . | NA | {
"id": "C0002893",
"name": "refractory anemia",
"pos": [
38,
55
]
} | {
"id": "C0002894",
"name": "refractory anemia with excess of blasts",
"pos": [
75,
114
]
} |
ra was associated more frequently with 11q deletions as the sole abnormality , while translocations or multiple chromosome abnormalities were commonly associated with raeb . | NA | {
"id": "C0002893",
"name": "ra",
"pos": [
0,
2
]
} | {
"id": "C0002894",
"name": "with raeb",
"pos": [
162,
171
]
} |
in contrast , ncs and smancs exhibited relatively lower toxicity to normal cells such as human skin fibroblasts and chick embryonic fibroblasts ( ic50 , about 50 and 100 nm , respectively ) . | NA | {
"id": "C0007634",
"name": "normal cells",
"pos": [
68,
80
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
132,
143
]
} |
the profile of endogenous carbohydrate-binding proteins ( lectins ) , the receptors for cellular glycoconjugates in a recognitive protein-carbohydrate interplay with potential relevance to metastases formation , revealed differences between these two human tumor samples of identical origin , especially with respect to beta-galactoside-specific receptors . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
97,
112
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
138,
150
]
} |
the use of a smaller subcloned region , a approximately 1.9kb fragment of dna from the 5 ' end of chicken fibronectin gene and wild type lambda dna showed approximately 2 fold increase in histone binding and approximately 7 fold increase in fibronectin binding , indicating preferential fibronectin binding with eukaryotic dna as compared to prokaryotic dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
11,
12
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
354,
357
]
} |
for the d-54 mg spheroids , flow cytometric dna measurements showed that the serum-free growth conditions caused a drop in the dna s-phase ( 6.4 % vs. 12.3 % in serum supplemented cultures ) . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
44,
47
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
135,
136
]
} |
structural and functional changes of membrane lipids and impaired lipid-protein interactions could be demonstrated in cll lymphocytes . | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
37,
52
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
66,
71
]
} |
acyclovir ( acv ) susceptibility assays revealed that some isolates were resistant to acv and cross-resistant to ganciclovir but not to phosphonoacetic acid . | NA | {
"id": "C0001367",
"name": "acv",
"pos": [
12,
15
]
} | {
"id": "C0017066",
"name": "ganciclovir",
"pos": [
113,
124
]
} |
these results suggest that ofloxacin could be transported via an amino acid transport system and that the fluorometric assay is a useful method for determining the intracellular penetration of fluoroquinolones , avoiding the use of radiolabeled antimicrobial agents . | NA | {
"id": "C0028902",
"name": "ofloxacin",
"pos": [
27,
36
]
} | {
"id": "C0949665",
"name": "fluoroquinolones",
"pos": [
193,
209
]
} |
rifabutin , a spiropiperidyl derivative of rifamycin , also reported to be active in the mouse model , was very effective . | NA | {
"id": "C0140575",
"name": "rifabutin",
"pos": [
0,
9
]
} | {
"id": "C0035609",
"name": "rifamycin",
"pos": [
43,
52
]
} |
interestingly , the macrolides erythromycin , clarithromycin , and roxithromycin were also found to be active in this system , while d-cycloserine and other cell wall synthesis inhibitors showed no effect . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
31,
43
]
} | {
"id": "C0055856",
"name": "clarithromycin",
"pos": [
46,
60
]
} |
interestingly , the macrolides erythromycin , clarithromycin , and roxithromycin were also found to be active in this system , while d-cycloserine and other cell wall synthesis inhibitors showed no effect . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
31,
43
]
} | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
67,
80
]
} |
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