text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
a concomitant treatment of cytomegalovirus infections , such as cytomegalovirus retinitis , with phosphonoformate in patients with acquired immunodeficiency syndrome receiving 3'-azido-3'-deoxythymidine may be appropriate , and this combination may also be useful in controlling human immunodeficiency virus infection . | NA | {
"id": "C0001175",
"name": "acquired",
"pos": [
131,
139
]
} | {
"id": "C0019693",
"name": "human",
"pos": [
279,
284
]
} |
ciprofloxacin , fleroxacin , and norfloxacin were compared with their precursor nalidixic acid and with trimethoprim in sublethal concentrations ranging from 1/32 to 1/4 of the mic . | NA | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
0,
13
]
} | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
16,
26
]
} |
ds1 exhibited tolerance to other dna gyrase a subunit antagonists ( ofloxacin and ciprofloxacin ) and dna gyrase b subunit antagonists ( novobiocin and coumermycin ) but not to the aminoglycoside gentamicin , suggesting involvement of dna gyrase . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
181,
195
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
196,
206
]
} |
in the present study , the pharmacokinetics of [ n-methyl-14c ] clarithromycin were compared with those of [ n-methyl-14c ] erythromycin in rats by radioassay and bioassay . | NA | {
"id": "C0055856",
"name": "clarithromycin",
"pos": [
64,
78
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
124,
136
]
} |
in the urine , bioactivity recovered after administration of [ 14c ] clarithromycin was sevenfold higher than that for [ 14c ] erythromycin . | NA | {
"id": "C0055856",
"name": "clarithromycin",
"pos": [
69,
83
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
127,
139
]
} |
this accounted for about 60 and 20 % of the total radioactivity in the urine for [ 14c ] clarithromycin and [ 14c ] erythromycin , respectively . | NA | {
"id": "C0055856",
"name": "clarithromycin",
"pos": [
89,
103
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
116,
128
]
} |
the mics for 78 of the isolates of the family enterobacteriaceae were greater than or equal to 64 micrograms of cefazolin , ampicillin , piperacillin , and mezlocillin per ml . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
124,
134
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
137,
149
]
} |
the mics for 78 of the isolates of the family enterobacteriaceae were greater than or equal to 64 micrograms of cefazolin , ampicillin , piperacillin , and mezlocillin per ml . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
124,
134
]
} | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
156,
167
]
} |
for a description of a trauma unit and a detailed analysis of the perioperative nurse 's role in caring for the trauma patient in the or , please see the accompanying article , `` '' perioperative nursing care of the multiple trauma patient : when seconds count . '' '' | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
23,
29
]
} | {
"id": "C0026771",
"name": "multiple traum",
"pos": [
217,
231
]
} |
treatment of rat hepatoma h-4-iie cells in culture with 2,3,7,8-tetrachlorodibenzo-p-dioxin ( tcdd ) , 2,3,7,8-tetrachlorodibenzofuran ( tcdf ) , 1,2,3,7,8-pentachlorodibenzo-p-dioxin ( pecdd ) , 1,2,3,7,8-pentachlorodibenzofuran ( pecdf ) , 1,2,7,8-tcdf , and 2,3,7-trichlorodibenzo-p-dioxin ( trcdd ) resulted in the structure-dependent induction of aryl hydrocarbon hydroxylase and ethoxyresorufin o-deethylase activities . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
352,
380
]
} | {
"id": "C0059735",
"name": "ethoxyresorufin o-deethylase",
"pos": [
385,
413
]
} |
we suggest that essential lysine residues , along with divalent metal ions , are located at the oprtase active site , and form ion-pair bonds with anionic pribpp and orotate as these substrates bind to the enzyme . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
70,
73
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
147,
154
]
} |
an in vitro expression plasmid ( pgrap ) that contained the cdna coding for the rat mitochondrial aldehyde dehydrogenase precursor was constructed , mrna was synthesized then translated , and the in vitro synthesized precursor of aldehyde dehydrogenase was used in an in vitro import assay . | NA | {
"id": "C2827577",
"name": "mitochondrial aldehyde dehydrogenase",
"pos": [
84,
120
]
} | {
"id": "C0001985",
"name": "aldehyde",
"pos": [
230,
238
]
} |
the development of a monoclonal antibody to bromodeoxyuridine ( brdurd ) , a thymidine analogue , is epoch making in the research of cell kinetics , and flow cytometry ( fcm ) combined with the antibody facilitates clinical use of information concerning cell kinetics of tumor cells . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
21,
40
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
194,
202
]
} |
the concentration of fk 973 required to inhibit cell growth by 50 % was 0.06-5 micrograms/ml , after 2-day exposure of this drug against human glioblastoma ( ons-6 , 12 , 23 , and ons-12/acnu ) , human medulloblastoma ( ons-76 , 81 ) , human neuroblastoma ( st ) , and murine glioblastoma ( rsv-m glioma ) . | NA | {
"id": "C0025149",
"name": "medulloblastoma",
"pos": [
202,
217
]
} | {
"id": "C0017638",
"name": "glioma",
"pos": [
297,
303
]
} |
deficits occurred for most major causes of death , including infectious and parasitic diseases , digestive and urinary systems , and accidents . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
61,
71
]
} | {
"id": "C0030499",
"name": "parasitic",
"pos": [
76,
85
]
} |
cytogenetic activity of 4'-epidoxorubicin was comparable to that of doxorubicin ( adriablastin ) widely used in medical practice . | NA | {
"id": "C0014582",
"name": "epidoxorubicin",
"pos": [
27,
41
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
68,
79
]
} |
it was shown that in both the media some amino acids such as serine , threonine , glutaminic and asparaginic acids were actively utilized by the strains mainly during the culture intensive growth while others such as glycine , alanine and tyrosine were actively utilized during the enzyme biosynthesis . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
41,
52
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
217,
224
]
} |
it was shown that in both the media some amino acids such as serine , threonine , glutaminic and asparaginic acids were actively utilized by the strains mainly during the culture intensive growth while others such as glycine , alanine and tyrosine were actively utilized during the enzyme biosynthesis . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
41,
52
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
227,
234
]
} |
in vivo toxicity of rnaase from b. intermedius was 3-5 times higher than that of pancreatic rnaase . | NA | {
"id": "C0014241",
"name": "rnaase",
"pos": [
20,
26
]
} | {
"id": "C0035541",
"name": "pancreatic rnaase",
"pos": [
81,
98
]
} |
it was shown with the method of serial dilutions on solid media that 91.7 , 87.8 , 85 and 81 per cent of the isolates were sensitive to benzylpenicillin , ampicillin , lincomycin and cefuroxime , respectively . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
136,
152
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
155,
165
]
} |
of the three basic amino acids , lysine shows the lowest labelling at all four measuring points . | NA | {
"id": "C0301714",
"name": "basic amino",
"pos": [
13,
24
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
33,
39
]
} |
although certain mcabs , when used as detecting antibody in the liquid phase , did not react with some of these antigens , they were able to bind to them when used as the capturing antibody on the solid phase . | NA | {
"id": "C0003250",
"name": "mcabs",
"pos": [
17,
22
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
181,
189
]
} |
neither an inactive phorbol ester , 4-alpha-phorbol-12 , 13-didecanoate , nor dimethyl sulfoxide ( dmso ) used as a solvent for pma had any effect . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
20,
33
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
128,
131
]
} |
to determine the mechanism by which substance p ( sp ) increases vascular permeability , we examined the potency of sp and sp fragments in inducing plasma extravasation in guinea pig skin , the effects of a histamine h1 antagonist and a muscarinic antagonist on the response , the effects of sp antagonists on the response , and the specificity of tachykinin-induced tachyphylaxis of the response . | NA | {
"id": "C0038585",
"name": "sp",
"pos": [
50,
52
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
348,
358
]
} |
we compared the endothelial protection offered by 1 % hyaluronate sodium ( healon ) , 3 % hyaluronate sodium and 4 % chondroitin sulfate ( viscoat ) , and a nonviscous irrigating solution ( bss plus ) during phacoemulsification with and without traumatic intraocular lens implantation . | NA | {
"id": "C0020196",
"name": "hyaluronate",
"pos": [
54,
65
]
} | {
"id": "C0087000",
"name": "hyaluronate sodium",
"pos": [
90,
108
]
} |
the latent period until fibroblast outgrowth began from the conjunctival explant was determined , as were the plating efficiency and doubling time of cells from first-passage cultures . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
24,
34
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
150,
155
]
} |
wiping the goldmann tonometer tip with an isopropyl alcohol swab and then allowing the alcohol to evaporate provides a ready and efficient means of inactivating these three enveloped viruses . | NA | {
"id": "C0022237",
"name": "isopropyl",
"pos": [
42,
51
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
87,
94
]
} |
incorporation of 14c-proline into proline and into hydroxyproline was taken as a measure of protein and collagen synthesis . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
21,
28
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
51,
65
]
} |
in contrast , canine beta-very low density lipoproteins ( beta-vldl ) , which contain apo e , bound to these cells with an affinity similar to that for fibroblasts of normal new zealand white rabbits ( kd approximately 0.6 micrograms/ml ) , although the maximal binding was only approximately 9 % of that of new zealand white cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
152,
163
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
326,
331
]
} |
the uptake of beta-vldl by whhl cells was mediated by the ldl receptor , since preincubation of the fibroblasts with cholesterol plus 25-hydroxycholesterol inhibited beta-vldl degradation , and specific antibodies to rabbit ldl receptors abolished the degradation of beta-vldl in whhl fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
32,
37
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
285,
296
]
} |
six-month-old , mfo-fed , female whhl rabbits had significantly lower plasma concentrations of total cholesterol ( 582 +/- 20 mg/dl vs. 856 +/- 44 mg/dl , control , p less than 0.05 ) and triglycerides ( 266 +/- 21 mg/dl vs. 459 +/- 15 mg/dl , control , p less than 0.05 ) , with lower serum/plasma lipoprotein concentrations [ very low density lipoprotein ( vldl ) , ldl , high density lipoprotein ( hdl ) ] compared to control female whhl rabbits . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
299,
310
]
} | {
"id": "C0023825",
"name": "very low density lipoprotein",
"pos": [
328,
356
]
} |
in the simultaneous administration of meprobamate and ethanol to rabbits , the blood meprobamate concentration ( bmc ) increased greatly when the maximum blood ethanol concentration ( becmax ) exceeded 1.0 mg/ml . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
54,
61
]
} | {
"id": "C0684262",
"name": "blood",
"pos": [
154,
159
]
} |
thus , we subjected the rabbits to continuous infusion of ethanol so as to make the blood ethanol concentration ( bec ) constant and administered meprobamate by intravenous injection . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
58,
65
]
} | {
"id": "C0684262",
"name": "blood ethanol",
"pos": [
84,
97
]
} |
everyone who cares for families with young children will be familiar with the pale sleepless look on a mother 's face , the bags under her eyes and the extra rouge worn to camouflage her fatigue if she is trying to cope with a child with a sleep disorder . | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
37,
51
]
} | {
"id": "C0008059",
"name": "child",
"pos": [
227,
232
]
} |
although the fingerprints generated from these viral rnas exhibited similar distribution patterns of non-unique rna fragments , all could be distinguished from one another on the basis of the migration of unique rna fragments . | NA | {
"id": "C0035736",
"name": "viral rnas",
"pos": [
47,
57
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
212,
215
]
} |
the combination of the light and temperature regime did not yield any significant differences for the carcass weight at conventional temperatures and for the body weight . | NA | {
"id": "C0005911",
"name": "differences",
"pos": [
82,
93
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
158,
169
]
} |
subsequently , purification to an apparently homogeneous state was achieved by chromatography on deae-cellulose , sepharose cl-6b and hydroxylapatite cellulose . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
97,
111
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
150,
159
]
} |
a single dose of 7.5 mg/100 g b.wt . metyrapone , intraperitoneally , decreased the concentration of reduced ( gsh ) and oxidized ( gssg ) glutathione in the liver and kidney of female wistar rats for approximately 4-5 h . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
132,
136
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
139,
150
]
} |
the ratio between gssg and gsh was not affected in the kidney but is decreased in the liver . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
18,
22
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
27,
30
]
} |
endothelin 1 , endothelin 3 and sarafotoxin all inhibited [ 125i ] -endothelin binding with ic50 's in the 100-300 pm range , whereas unrelated peptides , namely angiotensin ii , atrial natriuretic peptide , and platelet-derived growth factor failed to compete for [ 125i ] -endothelin binding . | NA | {
"id": "C0079281",
"name": "endothelin 1",
"pos": [
0,
12
]
} | {
"id": "C0079284",
"name": "endothelin",
"pos": [
275,
285
]
} |
endothelin 1 , endothelin 3 and sarafotoxin all inhibited [ 125i ] -endothelin binding with ic50 's in the 100-300 pm range , whereas unrelated peptides , namely angiotensin ii , atrial natriuretic peptide , and platelet-derived growth factor failed to compete for [ 125i ] -endothelin binding . | NA | {
"id": "C0079283",
"name": "endothelin 3",
"pos": [
15,
27
]
} | {
"id": "C0079284",
"name": "endothelin",
"pos": [
275,
285
]
} |
a pretreatment with alkaline phosphatase reduced the ability of pr to act as a substrate while the steroid occupancy of pr appeared to enhance the phosphorylation of the 114 kda peptide . | NA | {
"id": "C0034833",
"name": "pr",
"pos": [
2,
4
]
} | {
"id": "C0034840",
"name": "steroid",
"pos": [
99,
106
]
} |
however , the xanthate exerted an inhibitory effect on the tpa-stimulated liberation of [ 3h ] phosphorylcholine from [ 3h ] phosphatidylcholine in cells prelabeled with [ 3h ] choline . | NA | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
95,
112
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
177,
184
]
} |
the molecular weight , antibody crossreactivity , glycosidase sensitivity and lectin binding show that this protein is a normal kidney analogue of the p-glycoprotein induced in multidrug resistant cell lines . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
78,
84
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
158,
165
]
} |
bovine brain smg p25a , a guanine nucleotide-binding protein with a mr of about 25,000 , bound specifically gtp , guanosine 5'- ( 3-o-thio ) triphosphate ( gtp gamma s ) and gdp . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
108,
111
]
} | {
"id": "C0079469",
"name": "gtp gamma",
"pos": [
156,
165
]
} |
we investigated the molecular forms of endothelin ( et ) related peptides in porcine spinal cord by high performance liquid chromatography coupled with radioimmunoassays using three antisera raised against et-1 and c-terminal fragments of et-1 and big et-1 . | NA | {
"id": "C0079284",
"name": "endothelin",
"pos": [
39,
49
]
} | {
"id": "C0079281",
"name": "et-1",
"pos": [
252,
256
]
} |
although it is not known whether nf i functions as a protein kinase in addition to recognizing a specific sequence on dna , it is concluded that some of the eukaryotic dna binding proteins and protein kinases may belong to a gene family , various members of which are evolutionarily related and responsible for the regulation of metabolism in diverse compartments of the cell . | NA | {
"id": "C0069116",
"name": "nf i",
"pos": [
33,
37
]
} | {
"id": "C0012940",
"name": "dna binding proteins",
"pos": [
168,
188
]
} |
the dihydropyridine ca2+-channel antagonist nifedipine at 10 microm inhibited the [ ca2+ ] i response to pdgf by 41 % in both the presence of and in the absence of external ca2+ . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
4,
19
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
44,
54
]
} |
a substrate specificity of the kinase activity towards specific nuclear proteins is indicated by its phosphorylation of high mobility group ( hmg ) proteins isolated from endosperm and its lack of accepting histones as protein substrates . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
64,
80
]
} | {
"id": "C0019652",
"name": "histones",
"pos": [
207,
215
]
} |
a substrate specificity of the kinase activity towards specific nuclear proteins is indicated by its phosphorylation of high mobility group ( hmg ) proteins isolated from endosperm and its lack of accepting histones as protein substrates . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
64,
80
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
219,
226
]
} |
compound iii ( oxyperoxidase ) of lignin peroxidase isozyme h8 ( pi = 3.5 ) is formed by either reduction of native ferric enzyme ( to ferrous ) followed by the reaction with dioxygen or by the addition of excess hydrogen peroxide to resting enzyme . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
52,
59
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
242,
248
]
} |
these results suggest that the conjugation of ubiquitin to ubiquitin during polyubiquitin synthesis involves a specific conjugation system that recognizes ubiquitin and some of its derivatives , but not general proteolysis substrates , as ubiquitin acceptors . | NA | {
"id": "C0084133",
"name": "polyubiquitin",
"pos": [
76,
89
]
} | {
"id": "C0041538",
"name": "ubiquitin",
"pos": [
239,
248
]
} |
cholesterol esterification was examined in cultured skin fibroblasts from patients with i-cell disease and pseudo-hurler polydystrophy by incubating cells pretreated without fetal calf serum for 48h , with ( 14c ) cholesterol for 24h . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
57,
68
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
149,
154
]
} |
depression of the enzymatic activity is caused by a novel prolyendopeptidase inhibitor , whose amino acid composition is 7 glu , 1 ser , 2 gly , 1 ala , 2 pro , and 1 val , generated by inflammation . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
95,
105
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
139,
142
]
} |
without mtx pretreatment , 59 % of the total incorporation of fura into nucleic acids was into dna when fura was administered . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
72,
85
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
95,
98
]
} |
10 ( -4 ) m , damaged myocardial cells as reflected in a significant ( p less than 0.05 ) reduction in cellular protein and a further reduction in labelled choline in phosphocholine or phospholipid after adjusting for the lower protein concentrations . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
156,
163
]
} | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
167,
181
]
} |
anoxia , for 24 hr , produced a significant ( p less than 0.05 ) reduction in labelled choline in phosphocholine without a significant change in incorporation of label in phospholipid or cellular protein . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
87,
94
]
} | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
98,
112
]
} |
mn2+ ion forms 2-3 complexes with each conformer ( the cation being differently coordinated ) by substituting phosphoryl oxygens or n7 atoms of adenine for two water molecules in the hydration shell of the cation . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
5,
8
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
206,
212
]
} |
the better discriminating lipoproteins and apolipoproteins in mi patients in descending order were hdl2-cholesterol greater than apo b greater than apo a-i greater than vldl-triglyceride greater than hdl-cholesterol greater than ldl/hdl2-cholesterol greater than triglycerides . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
43,
58
]
} | {
"id": "C0003593",
"name": "apo b",
"pos": [
129,
134
]
} |
responsiveness of the calcified tissue to norepinephrine , epinephrine , serotonin , prostaglandin f2 alpha was found to be 11-66 % when compared to that of the control . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
42,
56
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
59,
70
]
} |
analyses of the cellular cholesterol ester content by gas-liquid chromatography and esterification of [ 14c ] cholesterol indicated the conversion of crystalline cholesterol to cholesterol esters . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
25,
36
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
177,
195
]
} |
the association of restriction fragment length polymorphism genetic markers at the apolipoprotein ai-ciii-aiv gene locus with lipid and lipoprotein levels was evaluated in subsets of the 666 caucasian students from the junior high school ( 11-14 years old ) population of muscatine , iowa . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
126,
131
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
136,
147
]
} |
by the simultaneous use of [ 3h ] cholesterol and [ 14c ] cholesterol it was shown that only 10-20 % of this disappearance can be explained by cholesteryl ester hydrolysis in the arterial wall . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
34,
45
]
} | {
"id": "C0008387",
"name": "cholesteryl",
"pos": [
143,
154
]
} |
clinical features in 9 cases with progressive myelopathy were not different from those previously described in tropical spastic paraparesis associated with htlv-i infection . | NA | {
"id": "C0030481",
"name": "tropical spastic paraparesis",
"pos": [
111,
139
]
} | {
"id": "C0020097",
"name": "htlv-i infection",
"pos": [
156,
172
]
} |
isotype evaluation of the antinuclear and related antibodies in the sigad group showed a greater tendency towards igg . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
0,
7
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
50,
60
]
} |
a complete model of the human leucocyte antigen molecule ( hla-a2 ) reconstructed from the alpha-carbon coordinates was used to investigate the putative organization of a tcr/peptide/hla-a2 complex . | NA | {
"id": "C0019728",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0019733",
"name": "hla-a2",
"pos": [
183,
189
]
} |
differentiation antigens can be simply defined as cell surface antigens that distinguish one cell type from another . | NA | {
"id": "C0003324",
"name": "differentiation antigens",
"pos": [
0,
24
]
} | {
"id": "C0003339",
"name": "cell surface antigens",
"pos": [
50,
71
]
} |
the ly-6 family of cell surface antigens might easily be regarded as a prototype for the analysis of the function of differentiation antigens on immunocompetent cells . | NA | {
"id": "C0003334",
"name": "ly",
"pos": [
4,
6
]
} | {
"id": "C0003324",
"name": "differentiation antigens",
"pos": [
117,
141
]
} |
the gastrointestinal hormone , gastric inhibitory polypeptide ( gip ) , has been isolated and characterized because of its enterogastrone-type effects . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormone",
"pos": [
4,
28
]
} | {
"id": "C0017132",
"name": "gastric inhibitory polypeptide",
"pos": [
31,
61
]
} |
being the prachtl 's neurological sieve a systematic condense analysis of neurologic screening which allows to establish a normal or suspicious neurologic condition at a sensibility of 0.85 , and specificity of 0.77 with a predictive value of 0.78 ( in our experience ) , we take it as an axis variable capable to discriminate among the population with and without risk of neurologic injury or sequela . | NA | {
"id": "C0027765",
"name": "neurologic",
"pos": [
21,
31
]
} | {
"id": "C0751792",
"name": "of neurologic injury",
"pos": [
370,
390
]
} |
the change in electrostatical potential-profile across the phospholipid membranes caused by the binding or sorption of ionic compounds ( metal cations , ionic surfactants , lipid-soluble ions , and ionophore-metal complexes ) can be estimated by the direct measuring method ( combination of zeta potential of lipid vesicles and surface potential of lipid monolayer ) . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
143,
150
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
187,
191
]
} |
variables significantly associated with hiv infection in the partners included advanced clinical stage ( aids-related complex or aids ) , a low concentration of t4 lymphocytes and african nationality of the index case , young age of the partner , and more than 50 instances of sexual contact with the index cases . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
40,
53
]
} | {
"id": "C0001857",
"name": "aids-related complex",
"pos": [
105,
125
]
} |
variables significantly associated with hiv infection in the partners included advanced clinical stage ( aids-related complex or aids ) , a low concentration of t4 lymphocytes and african nationality of the index case , young age of the partner , and more than 50 instances of sexual contact with the index cases . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
40,
53
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
129,
133
]
} |
in order to clarify whether hiv-1 core and env antigens are destroyed during pepsin treatment , used previously for detecting hiv-1 core and env antibodies hidden in circulating immune complexes , purified recombinant env and core antigen preparations were treated with pepsin . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
145,
155
]
} | {
"id": "C0003313",
"name": "circulating immune complexes",
"pos": [
166,
194
]
} |
eighteen infants born to anti-hiv-positive mothers were tested bimonthly for immunoglobulin m ( igm ) anti-hiv by western blot and hiv p24 antigen ( ag ) by enzyme-linked immunosorbent assay ( elisa ) in order to determine the role of these markers in the early diagnosis of hiv infection . | NA | {
"id": "C0019699",
"name": "hiv-positive",
"pos": [
30,
42
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
275,
288
]
} |
the inhibition of these enzymes at 0.1 % triton x-100 was present over an eightfold range of membrane protein in the assay indicating an independence of the protein/detergent ratio . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
93,
109
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
157,
164
]
} |
these results demonstrate that cerulenin blocks aldehyde synthesis by covalent reaction with the acyl-coa reductase and indicate that the reaction may occur at a cysteine residue involved in the formation of the acyl-reductase intermediate . | NA | {
"id": "C0050688",
"name": "acyl-coa reductase",
"pos": [
97,
115
]
} | {
"id": "C0085744",
"name": "acyl-reductase",
"pos": [
212,
226
]
} |
the o-polysaccharide fraction obtained by mild acetic acid hydrolysis of the s. madelia lipopolysaccharide was analyzed by chemical composition , nitrous acid deamination , periodate oxidation , methylation , and 1h and 13c nuclear magnetic resonance methods and was demonstrated to be composed of three polysaccharides , ps ( i ) , ps ( ii ) , and ps ( iii ) , which had the structures of repeating oligosaccharide units : ( formula ; see text ) | NA | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
304,
319
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
400,
415
]
} |
the expression of fine and intermediate filaments in 10 cases of leiomyosarcoma originating from a large vein , 9 cases of vascular leiomyoma ( angiomyoma ) and one case of a leiomyoma originating from the wall of the saphena magna vein was studied immunohistochemically by using 6 different anti-desmin antibodies , one anti-vimentin antibody and 2 antibodies to muscle-specific isoforms of actin . | NA | {
"id": "C0206653",
"name": "angiomyoma",
"pos": [
144,
154
]
} | {
"id": "C0023267",
"name": "leiomyoma",
"pos": [
175,
184
]
} |
blood samples analysed by high performance liquid chromatography for zeranol , its precursor zearalenone , and its main metabolites did not show any of these compounds above the laboratory limit of detection . | NA | {
"id": "C0043465",
"name": "zeranol",
"pos": [
69,
76
]
} | {
"id": "C0043454",
"name": "zearalenone",
"pos": [
93,
104
]
} |
one patient was delivered by caesarean section because of twin pregnancy with malpresentation , and two pregnancies are still ongoing beyond the first trimester . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
104,
115
]
} | {
"id": "C0032979",
"name": "first",
"pos": [
145,
150
]
} |
the excretion of 5-oxoproline/creatinine ( mumol/mmol ) rose progressively as pregnancy advanced ( non-pregnant mean 10 , sd 5 , first trimester mean 46 , sd 12 , second trimester mean 150 , sd 180 , and third trimester mean 280 , sd 320 ) and by the third trimester was over 20 times greater than in non-pregnant women . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
78,
87
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
129,
144
]
} |
the excretion of 5-oxoproline/creatinine ( mumol/mmol ) rose progressively as pregnancy advanced ( non-pregnant mean 10 , sd 5 , first trimester mean 46 , sd 12 , second trimester mean 150 , sd 180 , and third trimester mean 280 , sd 320 ) and by the third trimester was over 20 times greater than in non-pregnant women . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
78,
87
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
163,
179
]
} |
the excretion of 5-oxoproline/creatinine ( mumol/mmol ) rose progressively as pregnancy advanced ( non-pregnant mean 10 , sd 5 , first trimester mean 46 , sd 12 , second trimester mean 150 , sd 180 , and third trimester mean 280 , sd 320 ) and by the third trimester was over 20 times greater than in non-pregnant women . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
78,
87
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
251,
266
]
} |
in common with many other mitochondrial proteins encoded in nuclear genes , the deduced protein sequence has an n-terminal extension that is absent from the mature protein . | NA | {
"id": "C0949610",
"name": "mitochondrial proteins",
"pos": [
26,
48
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
164,
171
]
} |
the location and sequence of alpha-helices in mammalian cytochromes p450 were predicted from their homology with those of cytochrome p450cam , and these sequences were generally confirmed as helical in nature by using a secondary structure prediction method . | NA | {
"id": "C0010762",
"name": "cytochromes",
"pos": [
56,
67
]
} | {
"id": "C0054563",
"name": "p450cam",
"pos": [
133,
140
]
} |
other than these differences the model of mammalian cytochromes p450 proposed maintains the general structure of cytochrome p450cam as determined by its alpha-helical composition . | NA | {
"id": "C0010762",
"name": "cytochromes p450",
"pos": [
52,
68
]
} | {
"id": "C0054563",
"name": "p450cam",
"pos": [
124,
131
]
} |
hence in the asp and glu mutant proteins , both reduction and cyanide binding are accompanied by proton uptake by the protein . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
25,
40
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
118,
125
]
} |
the divalent cations magnesium , calcium , copper , strontium , and barium were much less effective , although all cations precipitate chromatin if their concentration is increased . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
4,
20
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
115,
122
]
} |
the results show that all three inhibitors form complexes with both isozymes that have 2:1 inhibitor/enzyme stoichiometry . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
68,
76
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
101,
107
]
} |
the 3h-methylated calmodulin product was purified by reverse-phase hplc and digested with various proteases including trypsin , chymotrypsin , endoproteinase lys-c , clostripain , and staphylococcus aureus v8 protease , and the resulting peptides were separated by reverse-phase hplc . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
98,
107
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
209,
217
]
} |
the effect of the protein environment on the reaction sequence and the relative rates of two two-step reactions involved in the biosynthesis of complex glycans in glycoproteins has been explored by comparing the processing of biotinylated substrates either free or bound to avidin . | NA | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
163,
176
]
} | {
"id": "C0004434",
"name": "avidin",
"pos": [
274,
280
]
} |
the incorporation of eight 14c-labeled fatty acids into human neutrophil phospholipids was investigated and the results were expressed as percent of the total phospholipid associated 14c-labeled substrate incorporated after an initial 15 min labeling and a subsequent 2 h reincubation in fatty acid-free buffer . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
39,
50
]
} | {
"id": "C0015688",
"name": "fatty acid-free",
"pos": [
288,
303
]
} |
neuroblastoma and hybrid cells had almost identical phospholipid and phosphoinositide compositions and similar activities for the enzymes metabolizing polyphosphoinositides ( pi kinase , pip phosphatase , pip kinase , pip2 phosphatase , pip2 phosphodiesterase ) . | NA | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
151,
172
]
} | {
"id": "C0070798",
"name": "pip2",
"pos": [
237,
241
]
} |
a quantitative analysis of fatty acid release by phospholipase a2 from the microsomal membrane revealed that only 5 nmol of free fatty acid per mg microsomal protein was released , including oleic acid and arachidonic acid , by treatment with 0.4 unit of phospholipase a2 per mg microsomal protein for 15 s at 23 degrees c . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
27,
37
]
} | {
"id": "C0015688",
"name": "free",
"pos": [
124,
128
]
} |
the results show that the three lectins are different from the soluble beta-galactoside-binding lectins studied thus far . | NA | {
"id": "C0023206",
"name": "lectins",
"pos": [
32,
39
]
} | {
"id": "C0607430",
"name": "beta-galactoside-binding lectins",
"pos": [
71,
103
]
} |
conformational transitions were detected for the pancreatic zymogen -- -- phospholipase a2 transformation and different secondary contents were observed for a toxic and a nontoxic form of the phospholipase molecule . | NA | {
"id": "C0031667",
"name": "phospholipase a2",
"pos": [
74,
90
]
} | {
"id": "C0031672",
"name": "a",
"pos": [
202,
203
]
} |
fluorescence decay measurement of the holoenzyme revealed that the fluorescence lifetime derived from the coenzyme , pyridoxal 5'-phosphate ( plp ) , was dependent on coexisting monovalent cations , whereas that of the tryptophyl residue was not , in either the apo- or the holoenzyme preparation . | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
106,
114
]
} | {
"id": "C0034266",
"name": "pyridoxal 5",
"pos": [
117,
128
]
} |
the observed incorporation of lps into ldl particles was not possibly associated with a transfer of lipids or proteins from high density lipoproteins to ldl . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
30,
33
]
} | {
"id": "C0023767",
"name": "a",
"pos": [
90,
91
]
} |
it was found that incubation of sera obtained from normolipidemic donors with cholesterol-loaded fibroblasts results in a decrease of the proportion of all small-sized particles of the hdl3 subclass , i.e. , hdl3a , hdl3b and hdl3c as well as in an increase in the proportion of large-sized particles of the hdl2 subclass ( hdl2a and hdl2b ) due to cholesterol acceptance by hdl . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
78,
89
]
} | {
"id": "C0023822",
"name": "cholesterol",
"pos": [
349,
360
]
} |
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