text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the effect of gtp is manifested only before hatching , whereas that of gpp ( nh ) p -- at later periods , i.e. , in 1-month-old chickens . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
14,
17
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
71,
83
]
} |
pe rats were administered , s.c. , saline ( sal ) , naloxone ( nal ) or naltrexone ( ntx ) once daily for 20 days , or repetitively on day 1 and on successive proestrus days if cyclicity was resumed . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
52,
60
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
72,
82
]
} |
single ntx ( 50 mg/kg ) , but not nal ( 2 mg/kg ) , treatment interrupted the pe state in almost half of treated animals . | NA | {
"id": "C0027360",
"name": "ntx",
"pos": [
7,
10
]
} | {
"id": "C0027358",
"name": "nal",
"pos": [
34,
37
]
} |
we have examined direct effects of epinephrine ( epi ) , norepinephrine ( ne ) , the beta-adrenergic agonist isoproterenol ( iso ) , and the alpha-adrenergic agonist phenylephrine ( phe ) on testicular testosterone ( t ) production in hamsters with gonadal regression induced by 12 wk exposure to short photoperiod ( sd ) and in gonadally active hamsters maintained in long photoperiod ( ld ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
35,
46
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
57,
71
]
} |
however , epi , ne , and phe at 10 ( -5 ) m , but not iso , augmented the stimulation of t by hcg . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
10,
13
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
16,
18
]
} |
in sharp contrast to these findings , t production by the regressed testes of sd animals was stimulated by epi ( at 10 ( -8 ) -10 ( -5 ) m ) , ne ( at 10 ( -6 ) -10 ( -5 ) m ) , and phe ( at 10 ( -6 ) -10 ( -5 ) m ) in a dose-related manner , but unaffected by iso . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
107,
110
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
237,
239
]
} |
moreover , 10 ( -5 ) m of epi , ne , and phe augmented the stimulatory effect of hcg on t production . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
26,
29
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
32,
34
]
} |
the major secreted protein of the human decidua ( pregnancy-associated endometrial alpha 1-globulin [ alpha 1-peg ] ) , is an insulin-like growth factor-binding protein ( igf-bp ) that is immunologically and biochemically similar to placental protein 12 ( pp12 ) extracted from term human placenta . | NA | {
"id": "C0074825",
"name": "insulin-like growth",
"pos": [
126,
145
]
} | {
"id": "C0123256",
"name": "placental protein 12",
"pos": [
233,
253
]
} |
the radius of gyration of tetrameric phosphorylase b was determined and found to be in excellent agreement with that of phosphorylase a , but different from that of phosphorylase b reported elsewhere ( g. puchwein , o. kratky , c. f. golker and e. helmreich , biochemistry 9 ( 1970 ) 4691 ) . | NA | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
37,
50
]
} | {
"id": "C0031711",
"name": "phosphorylase",
"pos": [
165,
178
]
} |
these studies show that telestability effects on thermal denaturation as predicted from equilibrium helix melting theory of linear dna molecules may explain all the features that are revealed by studying the extrusion of cruciforms in circular dna molecules subjected to superhelical stress . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
131,
134
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
235,
247
]
} |
to probe the molecular interactions of factor xi we have prepared two monoclonal antibodies ( moabs ; 5f7 and 3c1 ) , each of which binds the heavy chain of reduced and alkylated factor xia . | NA | {
"id": "C0015522",
"name": "factor xi",
"pos": [
39,
48
]
} | {
"id": "C0015524",
"name": "factor xia",
"pos": [
179,
189
]
} |
one antibody ( 5f7 ) blocked the surface-mediated proteolytic activation of factor xi and its binding to hmw kininogen , but had no effect on factor-xia-catalyzed factor ix activation . | NA | {
"id": "C0015522",
"name": "factor xi",
"pos": [
76,
85
]
} | {
"id": "C0015524",
"name": "factor-xia",
"pos": [
142,
152
]
} |
the other antibody ( 3c1 ) is a competitive inhibitor of factor-ix activation by factor xia , but blocked factor-xi binding to hmw kininogen only at 1,000-fold higher concentration than 5f7 . | NA | {
"id": "C0015524",
"name": "factor xia",
"pos": [
81,
91
]
} | {
"id": "C0015522",
"name": "factor-xi",
"pos": [
106,
115
]
} |
our results indicate that distinct functional domains within the heavy chain region of factor xi are important for the binding of factor xi to hmw kininogen and for activation of factor ix by factor xia . | NA | {
"id": "C0015522",
"name": "factor xi",
"pos": [
87,
96
]
} | {
"id": "C0015524",
"name": "factor xia",
"pos": [
192,
202
]
} |
preliminary reports of a temporal relationship between administration of these drugs to viral carriers and development of aids raised the possibility that they can modify the course of hiv infection . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
122,
126
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
185,
198
]
} |
although it has been demonstrated that lymphokine-activated killer ( lak ) cells kill tumor cells in a selective way without being toxic to a variety of normal cells , contradictory results exist about the possible toxicity of natural killer ( nk ) and lak cells for hematopoietic progenitor cells . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
153,
159
]
} | {
"id": "C0018956",
"name": "cells",
"pos": [
292,
297
]
} |
these data suggest that sodium butyrate may have therapeutic potential for increasing gamma globin expression in the beta globin diseases . | NA | {
"id": "C0017033",
"name": "gamma",
"pos": [
86,
91
]
} | {
"id": "C0005221",
"name": "beta globin",
"pos": [
117,
128
]
} |
fetal hepatic bfu-e , unlike adult bone marrow ( bm ) or peripheral blood ( pb ) bfu-e , were capable of proliferating in response to erythropoietin in the absence of added gm colony-stimulating factor ( gm-csf ) or interleukin-3 ( il-3 ) , and erythropoietin ( epo ) directly stimulated the expansion of the fetal bfu-e pool in suspension culture . | NA | {
"id": "C0009392",
"name": "colony-stimulating",
"pos": [
176,
194
]
} | {
"id": "C0021757",
"name": "interleukin-3",
"pos": [
216,
229
]
} |
fetal hepatic bfu-e , unlike adult bone marrow ( bm ) or peripheral blood ( pb ) bfu-e , were capable of proliferating in response to erythropoietin in the absence of added gm colony-stimulating factor ( gm-csf ) or interleukin-3 ( il-3 ) , and erythropoietin ( epo ) directly stimulated the expansion of the fetal bfu-e pool in suspension culture . | NA | {
"id": "C0009392",
"name": "colony-stimulating",
"pos": [
176,
194
]
} | {
"id": "C0014822",
"name": "erythropoietin",
"pos": [
245,
259
]
} |
all adult pb bfu-e were ep 3- but became ep 3+ after stimulation with gm-csf or il-3 . | NA | {
"id": "C0009392",
"name": "gm-csf",
"pos": [
70,
76
]
} | {
"id": "C0021757",
"name": "il-3",
"pos": [
80,
84
]
} |
both factor-dependent cell lines were cultured with recombinant il-1 alpha , il-2 , il-3 , il-6 , and gm colony-stimulating factor ( csf ) and semipurified b-cell growth factor ( bcgf ) interleukin-4 ( il-4 ) . | NA | {
"id": "C0021757",
"name": "il-3",
"pos": [
84,
88
]
} | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
105,
130
]
} |
in undifferentiated leukemic cells with no or few surface receptors for some of these proteins , there was an upregulation of the number of receptors during differentiation for the proteins to which the cells responded . | NA | {
"id": "C0025252",
"name": "surface",
"pos": [
50,
57
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
181,
189
]
} |
both zeta and theta gene expression appears erythroid specific in that neither mrna species is detected in rna isolated from brain tissue , peripheral blood mononuclear cells , or three nonerythroid cell lines ( b-lymphocyte , t-lymphocyte , and hepatoma cell lines ) . | NA | {
"id": "C0035696",
"name": "mrna",
"pos": [
79,
83
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
107,
110
]
} |
it does not recognize low-molecular-weight kininogen ( lk ) with which hk shares its heavy chain moiety or any antigens in human plasma congenitally deficient in kininogens . | NA | {
"id": "C0023922",
"name": "low-molecular-weight kininogen",
"pos": [
22,
52
]
} | {
"id": "C0022713",
"name": "kininogens",
"pos": [
162,
172
]
} |
a hybridoma ( 8c2-5 ) has been isolated that secretes an antibody ( moab/8c2-5 ) with the following characteristics : ( a ) igg1 , kappa isotype ; | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
57,
65
]
} | {
"id": "C0003250",
"name": "moab",
"pos": [
68,
72
]
} |
a hybridoma ( 8c2-5 ) has been isolated that secretes an antibody ( moab/8c2-5 ) with the following characteristics : ( a ) igg1 , kappa isotype ; | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
57,
65
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
137,
144
]
} |
the deamination of adenosine and adenosine monophosphate in plasmodium falciparum-infected human erythrocytes : in vitro use of 2'deoxycoformycin and amp deaminase-deficient red cells . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
19,
28
]
} | {
"id": "C0001465",
"name": "adenosine monophosphate",
"pos": [
33,
56
]
} |
these findings establish that deamination of adenosine and/or amp are not essential for plasmodial growth . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
45,
54
]
} | {
"id": "C0001465",
"name": "amp",
"pos": [
62,
65
]
} |
as observed in the tumor cell line mia paca-2 , a 4.3-kilobase ( kb ) transcript was detected in all cases using a human colony-stimulating factor ( csf ) -1 probe . | NA | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
121,
146
]
} | {
"id": "C0079784",
"name": "csf",
"pos": [
149,
152
]
} |
gamma-ifn was given at a daily dosage of 0.50 mg ( = 10 x 10 ( 6 ) u ) /m2 from the 3rd week of treatment on , but the dosage had to be reduced to 0.25 mg/m2 in 10 cases and to 0.35 mg/m2 in 2 cases , because of the severity and persistence of side effects ( mainly fever , fatigue , headache and pain ) . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
284,
292
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
297,
301
]
} |
the comparison of glycoprotein specific anti-platelet antibodies shows partly considerable differences which may be due to the different methods as well as the different antibodies used ( monoclonal antibody against membrane glycoprotein and antihuman globulin sera ) . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
18,
30
]
} | {
"id": "C0025248",
"name": "membrane glycoprotein",
"pos": [
216,
237
]
} |
the comparison of glycoprotein specific anti-platelet antibodies shows partly considerable differences which may be due to the different methods as well as the different antibodies used ( monoclonal antibody against membrane glycoprotein and antihuman globulin sera ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
54,
64
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
188,
198
]
} |
mitoxantrone , an anthracenedione , has been shown to be as effective as doxorubicin , but with less local or systemic toxicity , when used for the treatment of advanced breast cancer . | NA | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
0,
12
]
} | {
"id": "C0003174",
"name": "anthracenedione",
"pos": [
18,
33
]
} |
in contrast , bilateral intranigral injection of the selective delta agonist d-pen2 , d-pen5 enkephalin ( dpdpe ) elicited dose-dependent exploratory behavior and rearing but failed to produce gnawing . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
93,
103
]
} | {
"id": "C0525856",
"name": "dpdpe",
"pos": [
106,
111
]
} |
wheat germ-agglutinin conjugated horseradish peroxidase ( wga-hrp ) was used to delineate trigeminocerebellar connections in the pigeon . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
33,
55
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
58,
65
]
} |
naloxone ( 2.0 and 20 mg/kg ) and naltrexone ( 2.0 and 20 mg/kg ) suppressed self-stimulation only after a significant delay , in an extinction-like response decrement pattern , mimicking the effects of reductions in current intensity ( 75 % and 50 % of baseline ) . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
0,
8
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
34,
44
]
} |
when sodium depletion was prevented by giving the animals 1 % sodium bicarbonate in their drinking water , the majority of cells ( 45 out of 49 ) responded most strongly to the sight or visual approach of food compared to water or salt . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
90,
104
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
222,
227
]
} |
the precise course and termination levels of the corticospinal tract ( cst ) in the cat were studied using the anterograde transport of wheat germ agglutinin-conjugated horseradish peroxidase ( wga-hrp ) . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
169,
191
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
194,
201
]
} |
the recent availability of high specific activity radiolabeled dopaminergic antagonists with specificity for dopamine receptor subtypes has allowed us to screen a wide variety of cultured mammalian cell lines for the presence of d1 and d2 dopamine receptors . | NA | {
"id": "C0034798",
"name": "dopamine receptor",
"pos": [
109,
126
]
} | {
"id": "C0058698",
"name": "d2 dopamine receptors",
"pos": [
236,
257
]
} |
these data suggest that norepinephrine release into monkey csf , as an index of central or peripheral norepinephrine turnover , is more sensitive to alpha 2-adrenergic agonists than in csf dopamine or epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
24,
38
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
201,
212
]
} |
the antigens present in an extract of dog hair and dander were examined by crossed immunoelectrophoresis ( cie ) and the ige-binding allergens by crossed radio-immunoelectrophoresis ( crie ) , respectively , using sera from 60 british and finnish animal-allergic subjects . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
4,
12
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
133,
142
]
} |
the ranking of the antigens as allergens was similar for the two populations except that dsa was more important for the british than for the finnish subjects . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
19,
27
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
31,
40
]
} |
further development of the wound epidermis was accomplished by the successive supplementation of precursor cells from the newly formed regeneration blastema ( mainly rhabdite-forming cells ) . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
97,
112
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
183,
188
]
} |
in contrast to most other cells investigated by this technique , the main element detectable in the lens was sulfur , not phosphorus . | NA | {
"id": "C0013879",
"name": "element",
"pos": [
74,
81
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
122,
132
]
} |
simultaneous application of cyclosporine a ( csa ) and the phorbol ester 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) on mouse skin strongly inhibits various biological responses to tpa . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
59,
72
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol-13-acetate",
"pos": [
73,
110
]
} |
the inhibitory properties of each disaccharide are interpreted in terms of conformational comparisons with sucrose . | NA | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
34,
46
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
107,
114
]
} |
observations indicate that the first discernible event in myotendinous junction formation is the appearance of basement membrane at the incipient junction at 9-10 days postfertilization , concomitant with the aggregation of fibroblasts at the junctional regions of myogenic cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
224,
235
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
274,
279
]
} |
we have analyzed mixed cultures of normal mammalian fibroblastic cells and transformed quail myoblasts to investigate whether the presence of an excess of normal cells could suppress the phenotype of transformed quail cells . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
52,
64
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
183,
186
]
} |
this activation of endogenous myod1 mrna was also observed in swiss 3t6 cells , but not in several other fibroblast or adipoblast cell lines transfected with the myod1 cdna . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
72,
77
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
105,
115
]
} |
neurons and support cells of each sensory organ in drosophila embryos are most likely derived from a single precursor cell . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
20,
25
]
} | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
108,
122
]
} |
an activity promoting specific termination of heavy strand transcripts copurified with the dna binding protein ( s ) , pointing to the involvement of this protein in transcription termination . | NA | {
"id": "C0012940",
"name": "dna binding protein",
"pos": [
91,
110
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
155,
162
]
} |
in this study we have examined the cellular and molecular specificity of lymphocyte interaction with fibroblasts . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
35,
43
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
101,
112
]
} |
206 cycles ( 65.6 % ) were stimulated by means of clomiphene citrate and 108 cycles ( 34.4 % ) by a combination of clomiphene with hmg . | NA | {
"id": "C0546859",
"name": "clomiphene citrate",
"pos": [
50,
68
]
} | {
"id": "C0009008",
"name": "clomiphene",
"pos": [
115,
125
]
} |
we suggest that the substitution of valine for isoleucine at position a2 is responsible for all or most of the diminution in potency of owl monkey insulin relative to porcine insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
147,
154
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
167,
182
]
} |
cinx and na were found to bind mainly to albumin in human serum , the latter interacting with the protein about ten times as strongly as cinx at ph 7.4 and 37 degrees c . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
41,
48
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
98,
105
]
} |
anisotropy factors for the icd bands at 350-271 nm for cinx and 320-348 nm for na were approximately similar between hsa and rsa , suggesting a similar ability to generate the icd spectra in these wavelength regions upon binding to the albumins . | NA | {
"id": "C0304925",
"name": "hsa and rsa",
"pos": [
117,
128
]
} | {
"id": "C0001924",
"name": "albumins",
"pos": [
236,
244
]
} |
polyclonal antibodies for 3,2'-dimethyl-4-aminobiphenyl ( dmab ) -dna adducts were obtained from the sera of rabbits immunized with n-oh-dmab-modified dna . | NA | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
66,
77
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
151,
154
]
} |
there was no significant difference between this control group and a negative calcium control group fed 128 mmol/kg chow of calcium as calcium gluconate . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
78,
85
]
} | {
"id": "C0006699",
"name": "calcium gluconate",
"pos": [
135,
152
]
} |
the pi efflux system is independent of na+ ions and is not influenced by the nature of the chief anion present in the bathing medium . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
43,
47
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
97,
102
]
} |
rewarming from 1 degree to 30 degrees c ( in less than 0.5 second ) activates mechanisms that contribute to the reduction of intracellular calcium concentration and thus relaxation ( e.g. , sarcoplasmic reticulum [ sr ] calcium pump and sarcolemmal na-ca exchange and calcium pump ) . | NA | {
"id": "C0916181",
"name": "sarcoplasmic",
"pos": [
190,
202
]
} | {
"id": "C0001476",
"name": "calcium pump",
"pos": [
268,
280
]
} |
the following parameters were studied : 1 ) calcium-magnesium-activated and magnesium-activated atpase activity of washed and purified myofibrils , 2 ) calcium-activated atpase activity of purified myosin , 3 ) isomyosin composition and relative content of alpha-myosin heavy chains ( alpha-mhcs ) , and 4 ) force-velocity curve of left and right ventricle papillary muscles . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
198,
204
]
} | {
"id": "C0027100",
"name": "myosin heavy",
"pos": [
263,
275
]
} |
dilatation for 10 minutes caused an increase in inositol monophosphate , inositol bisphosphate , and inositol trisphosphate from 23.3 +/- 0.9 , 15.4 +/- 0.4 , and 9.5 +/- 0.3 cpm/mg tissue ( mean +/- sem , n = 7 ) to 74.6 +/- 2.3 , 20.2 +/- 1.3 , and 13.6 +/- 1.5 cpm/mg tissue ( n = 8 ) , respectively ( p less than 0.01 for all inositol phosphates ) . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
48,
56
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
330,
349
]
} |
serum il-6 activity correlated with serum concentrations of some acute phase proteins ( app ) , such as c-reactive protein , haptoglobin and alpha 1-acid glycoprotein , implying its role for modulating induction of app in vivo . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
104,
122
]
} | {
"id": "C0001347",
"name": "app",
"pos": [
215,
218
]
} |
serum il-6 activity correlated with serum concentrations of some acute phase proteins ( app ) , such as c-reactive protein , haptoglobin and alpha 1-acid glycoprotein , implying its role for modulating induction of app in vivo . | NA | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
125,
136
]
} | {
"id": "C0001347",
"name": "app",
"pos": [
215,
218
]
} |
serum il-6 activity correlated with serum concentrations of some acute phase proteins ( app ) , such as c-reactive protein , haptoglobin and alpha 1-acid glycoprotein , implying its role for modulating induction of app in vivo . | NA | {
"id": "C0029297",
"name": "alpha",
"pos": [
141,
146
]
} | {
"id": "C0001347",
"name": "app",
"pos": [
215,
218
]
} |
autoantibodies to defined cellular antigens in systemic lupus erythematosus ( sle ) are usually directed to conserved epitopes on ubiquitous macromolecules including histone , sm + nrnp ( urnp particles ) , dna , and la ( ssb ) . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
35,
43
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
118,
126
]
} |
we report here that the autoimmune response to the ro ( ssa ) rna protein particle is directed to epitopes on the human antigen which are not conserved in evolution . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
98,
106
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
120,
127
]
} |
though untreated coeliacs had high serum antibody levels towards gliadin and some gluten-derived peptides , antibody specificities to various toxic gluten-derived peptides were similar to normal patients . | NA | {
"id": "C0017622",
"name": "gliadin",
"pos": [
65,
72
]
} | {
"id": "C2362561",
"name": "gluten",
"pos": [
148,
154
]
} |
the specificities of several monoclonal antibodies which bound to wheat prolamins as well as prolamins from other coeliac-toxic cereals have also been investigated with these toxic gluten-derived peptides , in order to identify possible common epitopes . | NA | {
"id": "C2350325",
"name": "prolamins",
"pos": [
72,
81
]
} | {
"id": "C2362561",
"name": "gluten",
"pos": [
181,
187
]
} |
however the monoclonal antibodies which were specific for the coeliac-toxic cereal prolamins did show the strongest binding to other coeliac-toxic gluten-derived peptides . | NA | {
"id": "C2350325",
"name": "prolamins",
"pos": [
83,
92
]
} | {
"id": "C2362561",
"name": "gluten",
"pos": [
147,
153
]
} |
a simple monolayer invasion assay ( mia ) was recently developed using confluent fibroblastic cells as a target and variants of the bw5147 murine t-cell lymphoma as invading cells . | NA | {
"id": "C0016030",
"name": "fibroblastic cells",
"pos": [
81,
99
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
174,
179
]
} |
in the trauma category , the formation of ectopic bone is concerned with major and minor traumatic incidents , surgery , burns , and other causes . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
7,
13
]
} | {
"id": "C0006434",
"name": "burns",
"pos": [
121,
126
]
} |
31p-nmr spectra were obtained from the quadriceps femoris muscle ( at rest and after aerobic exercise ) of the 7 cases of mitochondrial myopathies ( 2 cases of mitochondrial encephalomyopathy and lactic acidosis ( mela ) , 1 case of myoclonus epilepsy with regged red fiber , 1 case of kearns-sayre syndrome , 3 cases of progressive external ophthalmoplegia ) , using superconducting whole body mr ( magnetom , siemens ) . | NA | {
"id": "C0162670",
"name": "mitochondrial myopathies",
"pos": [
122,
146
]
} | {
"id": "C0162674",
"name": "progressive external ophthalmoplegia",
"pos": [
321,
357
]
} |
right pulmonary effusion and extensive subcutaneous hemorrhage and necrotic gangrene in the leg was also noted . | NA | {
"id": "C0027540",
"name": "necrotic",
"pos": [
67,
75
]
} | {
"id": "C0017086",
"name": "gangrene",
"pos": [
76,
84
]
} |
cases of the painful oculomotor nerve palsy with paranasal lesion or history of parasinusitis are characterized by ( 1 ) predominant in male , ( 2 ) neurological manifestations unilaterally on the same side of paranasal lesion , and ( 3 ) frequent recurrence of neurological symptoms . | NA | {
"id": "C0030193",
"name": "painful",
"pos": [
13,
20
]
} | {
"id": "C0027854",
"name": "neurological manifestations",
"pos": [
149,
176
]
} |
x-ray ct and mri-ct showed spinal epidural hematoma , especially mri-ct made clear the relationship between spine and hematoma and the level of longitudinal expansion . | NA | {
"id": "C0877172",
"name": "spinal epidural hematoma",
"pos": [
27,
51
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
118,
126
]
} |
immunohistochemistry of the atrial cardiac muscle of an autopsied dmd case revealed many anp-positive atrial muscle cells , indicating the preservation of anp-secreting function . | NA | {
"id": "C1144709",
"name": "anp",
"pos": [
89,
92
]
} | {
"id": "C0027481",
"name": "anp",
"pos": [
155,
158
]
} |
there were 36 benign lesions ( parotitis , sjogren 's syndrome , adenoma , etc . ) and 24 malignant tumours ( squamous cell carcinoma , adenocarcinoma , adenoid cystic carcinoma etc . ) | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
136,
150
]
} | {
"id": "C0010606",
"name": "adenoid cystic",
"pos": [
153,
167
]
} |
overall , slime-producing coagulase-negative staphylococci were more likely to be s. epidermidis than any other species , but slime production was not associated with presence of pyuria , symptomatic urinary tract infection , instrumentation , nosocomial acquisition , or multiple antibiotic resistance . | NA | {
"id": "C0034359",
"name": "pyuria",
"pos": [
179,
185
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
200,
223
]
} |
that a mortality index which gives different weights to deaths at different ages should possibly be used instead of the simple smr to weight regional resource allocations for need ; | NA | {
"id": "C0005911",
"name": "different weights",
"pos": [
35,
52
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
134,
140
]
} |
these results suggest that the seal platelet may be a useful model for studying the metabolism and function of the omega 3 fatty acids , such as epa , in relation to platelet reactivity , phospholipid turnover and the formation of aa- and epa-derived eicosanoids . | NA | {
"id": "C0000545",
"name": "epa",
"pos": [
145,
148
]
} | {
"id": "C0013725",
"name": "eicosanoids",
"pos": [
251,
262
]
} |
patients with a previous contact allergy to lanolin ( wool alcohols and/or amerchol l 101 ) were patch tested 1 to 4 years later with lanolin allergens , as well as purified anhydrous lanolin contained in a commercial cream . | NA | {
"id": "C0023024",
"name": "lanolin",
"pos": [
44,
51
]
} | {
"id": "C0302228",
"name": "anhydrous lanolin",
"pos": [
174,
191
]
} |
the endotoxin-induced production of thromboxane a2 ( txa2 ) and prostacyclin ( pgi2 ) by peritoneal macrophages from horses which were hyperimmunized against the common core region of lps were compared to those in unimmunized horses . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
4,
13
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
184,
187
]
} |
in nine mongrel dogs , epi and ne levels were drawn before cardiac arrest and after 8 and 14 min of cardiac arrest and cpr . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
23,
26
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
31,
33
]
} |
this case illustrates the fact that not all nodules appearing within a lentigo maligna are melanoma . | NA | {
"id": "C0149722",
"name": "lentigo maligna",
"pos": [
71,
86
]
} | {
"id": "C0025202",
"name": "melanoma",
"pos": [
91,
99
]
} |
the patients had augmented circulating catecholamine levels , those for epinephrine increased in venous effluents but were maintained in brachial arterial inflow , and those for norepinephrine increased in arterial rather than venous plasma in the forearm . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
72,
83
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
178,
192
]
} |
nutritional parameters studied were percentage of ideal body weight , creatinine height index , serum albumin , serum prealbumin , serum transferrin , and total lymphocyte count . | NA | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
96,
109
]
} | {
"id": "C0032923",
"name": "prealbumin",
"pos": [
118,
128
]
} |
a retrospective review was performed on the files of 154 consecutive workers assessed for occupational asthma to clarify the relative frequency of asthma induced by irritants in the workplace and to determine whether such asthma was clearly distinguishable from other forms of occupational asthma . | NA | {
"id": "C0004096",
"name": "asthma",
"pos": [
103,
109
]
} | {
"id": "C0264423",
"name": "occupational asthma",
"pos": [
277,
296
]
} |
our findings suggest that irritant-induced asthma is not uncommon , and those affected may have different baseline characteristics from others with occupational asthma . | NA | {
"id": "C0004096",
"name": "asthma",
"pos": [
43,
49
]
} | {
"id": "C0264423",
"name": "occupational asthma",
"pos": [
148,
167
]
} |
cells that were immunoreactive to glucagon-like antibodies ( g-like cells ) first appeared under light microscopy on day 11 , and those immunoreactive to insulin-like antibodies ( i-like cells ) appeared on day 13 . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
48,
58
]
} | {
"id": "C0021644",
"name": "insulin",
"pos": [
154,
161
]
} |
the structure of mini-proinsulin is similar to that of proinsulin with a shortened c-peptide , b ( 1-29 ) -ala-ala-lys-a ( 1-21 ) insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
22,
32
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
83,
92
]
} |
the structure of mini-proinsulin is similar to that of proinsulin with a shortened c-peptide , b ( 1-29 ) -ala-ala-lys-a ( 1-21 ) insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
22,
32
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
130,
137
]
} |
anti-insulin immunoglobulin e ( ige ) antibodies in sera of insulin-treated diabetic patients were characterized by affinity and concentration , and by binding to proinsulin and insulin a and b chains . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
163,
173
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
178,
185
]
} |
dactimicin is a new aminoglycoside and its in vitro activity has been compared with that of gentamicin against 100 recent clinical isolates . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
20,
34
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
92,
102
]
} |
in this study the in vitro activity of dactimicin has been determined against strains of bacteria producing characterized aminoglycoside-modifying enzymes and has been compared with that of gentamicin , tobramycin , netilmicin and amikacin . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
122,
136
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
190,
200
]
} |
these results suggest that the acetylator genotype-dependent expression of accoa-dependent nat activity in hamster hepatic cytosol toward arylamines is primarily accountable by structural variants ( allozymes ) of polymorphic nat under the genetic regulation of the acetylator gene locus . | NA | {
"id": "C0001019",
"name": "accoa",
"pos": [
75,
80
]
} | {
"id": "C0001068",
"name": "nat",
"pos": [
226,
229
]
} |
parasitosis were particularly prevalent in herring gulls ( 49 % ) , where the main infection -- as in black-headed gulls -- was with cestoides . | NA | {
"id": "C0030499",
"name": "parasitosis",
"pos": [
0,
11
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
83,
92
]
} |
absolute content of gd3 increased more than twice in profuse growth from the inner surface and decreased almost three times in the cyst capsule as compared to the intact tumour . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
131,
135
]
} | {
"id": "C0027651",
"name": "tumour",
"pos": [
170,
176
]
} |
in the autistic group , epinephrine and norepinephrine and dopamine were significantly lower in isolated platelets , and no significant difference was found between the two groups for the urinary excretion of epinephrine , norepinephrine , dopamine , dopac and mhpg . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
24,
35
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
223,
237
]
} |
as a general rule , the administration of lithium should be avoided during pregnancy , at least during the first trimester . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
75,
84
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
107,
122
]
} |
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